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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dichloroaniline
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Accession:CHEBI:23696 term browser browse the term
Synonyms:related_synonym: Dichloranilin;   Formula=C6H5Cl2N;   dichloroanilines
 xref: CAS:27134-27-6;   Wikipedia:Dichloroaniline


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2,4-dichloroaniline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline CTD PMID:20199096 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
3,4-dichloroaniline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression EXP 3,4-dichloroaniline results in decreased expression of ACSS2 mRNA CTD PMID:24172598 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Acvr1c activin A receptor type 1C increases expression ISO 3,4-dichloroaniline results in increased expression of ACVR1C mRNA CTD PMID:24172598 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 increases expression ISO 3,4-dichloroaniline results in increased expression of ADAMTS9 mRNA CTD PMID:24172598 NCBI chr 4:124,660,254...124,860,997
Ensembl chr 4:124,660,262...124,858,250
JBrowse link
G Ajuba ajuba LIM protein decreases expression ISO 3,4-dichloroaniline results in decreased expression of AJUBA mRNA CTD PMID:24172598 NCBI chr15:33,208,210...33,218,456
Ensembl chr15:33,208,216...33,218,456
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO 3,4-dichloroaniline results in increased expression of AKR1C2 mRNA CTD PMID:24172598 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO 3,4-dichloroaniline results in increased expression of AKR1C3 mRNA CTD PMID:24172598 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression EXP 3,4-dichloroaniline results in increased expression of ALDH1A3 mRNA CTD PMID:24172598 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Anln anillin, actin binding protein decreases expression ISO 3,4-dichloroaniline results in decreased expression of ANLN mRNA CTD PMID:24172598 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
JBrowse link
G Anp32e acidic nuclear phosphoprotein 32 family member E decreases expression ISO 3,4-dichloroaniline results in decreased expression of ANP32E mRNA CTD PMID:24172598 NCBI chr 2:198,040,573...198,057,005
Ensembl chr 2:198,040,536...198,057,003
JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO 3,4-dichloroaniline results in increased expression of ANTXR2 mRNA CTD PMID:24172598 NCBI chr14:13,191,716...13,331,286
Ensembl chr14:13,192,347...13,274,978
JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of AOX1 mRNA CTD PMID:24172598 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression EXP 3,4-dichloroaniline results in increased expression of ASS1 mRNA CTD PMID:24172598 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO 3,4-dichloroaniline results in increased expression of ATF3 mRNA CTD PMID:24172598 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 increases expression ISO 3,4-dichloroaniline results in increased expression of ATP6V0D2 mRNA CTD PMID:24172598 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO 3,4-dichloroaniline results in decreased expression of AXL mRNA CTD PMID:24172598 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO 3,4-dichloroaniline results in increased expression of BMP6 mRNA CTD PMID:24172598 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G C3 complement C3 increases expression ISO
EXP
3,4-dichloroaniline results in increased expression of C3 mRNA CTD PMID:24172598 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Ccdc113 coiled-coil domain containing 113 decreases expression ISO 3,4-dichloroaniline results in decreased expression of CCDC113 mRNA CTD PMID:24172598 NCBI chr19:9,912,124...9,932,183
Ensembl chr19:9,912,183...9,931,930
JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of CCN1 mRNA CTD PMID:24172598 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO 3,4-dichloroaniline results in decreased expression of CCN2 mRNA CTD PMID:24172598 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdcp1 CUB domain containing protein 1 increases expression ISO 3,4-dichloroaniline results in increased expression of CDCP1 mRNA CTD PMID:24172598 NCBI chr 8:132,260,007...132,296,661
Ensembl chr 8:132,260,029...132,296,661
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO 3,4-dichloroaniline results in increased expression of CEACAM1 mRNA CTD PMID:24172598 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cep126 centrosomal protein 126 decreases expression ISO 3,4-dichloroaniline results in decreased expression of CEP126 mRNA CTD PMID:24172598 NCBI chr 8:6,237,838...6,305,127
Ensembl chr 8:6,255,850...6,305,033
JBrowse link
G Cfap20dc CFAP20 domain containing increases expression ISO 3,4-dichloroaniline results in increased expression of CFAP20DC mRNA CTD PMID:24172598 NCBI chr15:17,664,838...17,918,216
Ensembl chr15:17,775,692...17,924,302
JBrowse link
G Cfap300 cilia and flagella associated protein 300 decreases expression ISO 3,4-dichloroaniline results in decreased expression of CFAP300 mRNA CTD PMID:24172598 NCBI chr 8:6,218,391...6,236,438
Ensembl chr 8:6,218,393...6,235,967
JBrowse link
G Cldn11 claudin 11 decreases expression ISO 3,4-dichloroaniline results in decreased expression of CLDN11 mRNA CTD PMID:24172598 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Clgn calmegin increases expression ISO 3,4-dichloroaniline results in increased expression of CLGN mRNA CTD PMID:24172598 NCBI chr19:24,545,257...24,578,527
Ensembl chr19:24,545,318...24,576,798
JBrowse link
G Cndp1 carnosine dipeptidase 1 increases expression EXP 3,4-dichloroaniline results in increased expression of CNDP1 mRNA CTD PMID:24172598 NCBI chr18:81,466,717...81,512,841
Ensembl chr18:81,466,716...81,499,051
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain decreases expression ISO 3,4-dichloroaniline results in decreased expression of COL8A1 mRNA CTD PMID:24172598 NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
JBrowse link
G Cstb cystatin B increases expression ISO 3,4-dichloroaniline results in increased expression of CSTB mRNA CTD PMID:24172598 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
JBrowse link
G Ctse cathepsin E increases expression EXP 3,4-dichloroaniline results in increased expression of CTSE mRNA CTD PMID:24172598 NCBI chr13:48,426,833...48,449,493
Ensembl chr13:48,426,820...48,449,490
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP 3,4-dichloroaniline results in increased expression of CX3CL1 mRNA CTD PMID:24172598 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression EXP 3,4-dichloroaniline results in increased expression of CXCL5 mRNA CTD PMID:24172598 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of CYP17A1 mRNA CTD PMID:31100596 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO 3,4-dichloroaniline results in increased expression of CYP19A1 mRNA CTD PMID:31100596 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 3,4-dichloroaniline results in increased expression of CYP1A1 mRNA; 3,4-dichloroaniline results in increased expression of CYP1A1 protein CTD PMID:21784029 PMID:24172598 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 3,4-dichloroaniline results in increased expression of CYP1A2 mRNA; 3,4-dichloroaniline results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 3,4-dichloroaniline results in increased expression of CYP1B1 mRNA CTD PMID:24172598 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO 3,4-dichloroaniline results in increased expression of CYP4F3 mRNA CTD PMID:24172598 NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO 3,4-dichloroaniline results in increased expression of DNAJB9 mRNA CTD PMID:24172598 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dner delta/notch-like EGF repeat containing increases expression ISO 3,4-dichloroaniline results in increased expression of DNER mRNA CTD PMID:24172598 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases expression ISO 3,4-dichloroaniline results in increased expression of DPP4 mRNA CTD PMID:24172598 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Dst dystonin decreases expression ISO 3,4-dichloroaniline results in decreased expression of DST mRNA CTD PMID:24172598 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of EFEMP1 mRNA CTD PMID:24172598 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Egr1 early growth response 1 decreases expression EXP 3,4-dichloroaniline results in decreased expression of EGR1 mRNA CTD PMID:24172598 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression EXP 3,4-dichloroaniline results in decreased expression of ELOVL6 mRNA CTD PMID:24172598 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Eno2 enolase 2 increases expression ISO 3,4-dichloroaniline results in increased expression of ENO2 mRNA CTD PMID:24172598 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
Ensembl chr 9:157,285,179...157,294,047
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO 3,4-dichloroaniline results in increased expression of ENTPD3 mRNA CTD PMID:24172598 NCBI chr 8:129,201,000...129,232,436
Ensembl chr 8:129,201,669...129,232,677
JBrowse link
G Erp27 endoplasmic reticulum protein 27 decreases expression ISO 3,4-dichloroaniline results in decreased expression of ERP27 mRNA CTD PMID:24172598 NCBI chr 4:170,893,946...170,912,629
Ensembl chr 4:170,893,946...170,912,629
JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 decreases expression EXP 3,4-dichloroaniline results in decreased expression of FGFBP1 mRNA CTD PMID:24172598 NCBI chr14:71,647,429...71,650,359
Ensembl chr14:71,649,274...71,650,354
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B decreases expression ISO 3,4-dichloroaniline results in decreased expression of FKBP1B mRNA CTD PMID:24172598 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Fstl1 follistatin-like 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of FSTL1 mRNA CTD PMID:24172598 NCBI chr11:65,791,196...65,845,721
Ensembl chr11:65,782,567...65,845,418
JBrowse link
G Fyb1 FYN binding protein 1 increases expression ISO 3,4-dichloroaniline results in increased expression of FYB1 mRNA CTD PMID:24172598 NCBI chr 2:55,834,904...55,983,805
Ensembl chr 2:55,835,151...55,983,804
JBrowse link
G Gask1b golgi associated kinase 1B decreases expression ISO 3,4-dichloroaniline results in decreased expression of GASK1B mRNA CTD PMID:24172598 NCBI chr 2:178,678,946...178,751,459
Ensembl chr 2:178,679,041...178,750,668
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression EXP 3,4-dichloroaniline results in increased expression of GDF15 mRNA CTD PMID:24172598 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gjb6 gap junction protein, beta 6 decreases expression ISO 3,4-dichloroaniline results in decreased expression of GJB6 mRNA CTD PMID:24172598 NCBI chr15:37,400,888...37,411,656
Ensembl chr15:37,400,889...37,410,848
JBrowse link
G Has2 hyaluronan synthase 2 increases expression ISO 3,4-dichloroaniline results in increased expression of HAS2 mRNA CTD PMID:24172598 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases expression ISO 3,4-dichloroaniline results in increased expression of HPGD mRNA CTD PMID:24172598 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 increases expression ISO 3,4-dichloroaniline results in increased expression of HSD17B2 mRNA CTD PMID:24172598 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression EXP 3,4-dichloroaniline results in decreased expression of HSD17B7 mRNA CTD PMID:24172598 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO 3,4-dichloroaniline results in decreased expression of ID3 mRNA CTD PMID:24172598 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP 3,4-dichloroaniline results in decreased expression of IDI1 mRNA CTD PMID:24172598 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression EXP 3,4-dichloroaniline results in increased expression of IFITM3 mRNA CTD PMID:24172598 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO 3,4-dichloroaniline results in increased expression of IGFBP3 mRNA CTD PMID:24172598 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 decreases expression EXP 3,4-dichloroaniline results in decreased expression of IGFBP6 mRNA CTD PMID:24172598 NCBI chr 7:143,749,385...143,754,018
Ensembl chr 7:143,749,221...143,754,054
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO 3,4-dichloroaniline results in increased expression of IL1RL1 mRNA CTD PMID:24172598 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO 3,4-dichloroaniline results in increased expression of IL1RN mRNA CTD PMID:24172598 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression EXP 3,4-dichloroaniline results in increased expression of ITGA1 mRNA CTD PMID:24172598 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 decreases expression ISO 3,4-dichloroaniline results in decreased expression of KCNJ2 mRNA CTD PMID:24172598 NCBI chr10:99,429,337...99,442,520
Ensembl chr10:99,437,436...99,439,114
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO 3,4-dichloroaniline results in decreased expression of KIF20A mRNA CTD PMID:24172598 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Klhl13 kelch-like family member 13 decreases expression ISO 3,4-dichloroaniline results in decreased expression of KLHL13 mRNA CTD PMID:24172598 NCBI chr  X:121,578,965...121,735,014
Ensembl chr  X:121,578,940...121,731,543
JBrowse link
G Klhl24 kelch-like family member 24 increases expression EXP 3,4-dichloroaniline results in increased expression of KLHL24 mRNA CTD PMID:24172598 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Klrc3 killer cell lectin like receptor C3 decreases expression ISO 3,4-dichloroaniline results in decreased expression of KLRC3 mRNA CTD PMID:24172598 NCBI chr 4:163,416,373...163,427,331
Ensembl chr 4:163,416,351...163,445,302
JBrowse link
G Klrg2 killer cell lectin like receptor G2 decreases expression ISO 3,4-dichloroaniline results in decreased expression of KLRG2 mRNA CTD PMID:24172598 NCBI chr 4:66,370,674...66,381,351
Ensembl chr 4:66,371,511...66,380,734
JBrowse link
G Knl1 kinetochore scaffold 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of KNL1 mRNA CTD PMID:24172598 NCBI chr 3:110,847,304...110,909,807
Ensembl chr 3:110,855,000...110,909,807
JBrowse link
G Krt34 keratin 34 increases expression ISO 3,4-dichloroaniline results in increased expression of KRT34 mRNA CTD PMID:24172598 NCBI chr10:87,950,364...87,954,055
Ensembl chr10:87,950,001...87,954,055
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO 3,4-dichloroaniline results in increased expression of LAMB3 mRNA CTD PMID:24172598 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO
EXP
3,4-dichloroaniline results in increased expression of LCN2 mRNA CTD PMID:24172598 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G LOC103690190 histone H2A type 1-E increases expression ISO 3,4-dichloroaniline results in increased expression of H2AC6 mRNA CTD PMID:24172598 NCBI chr17:44,747,686...44,748,229
Ensembl chr17:44,747,796...44,748,188
Ensembl chr17:44,747,796...44,748,188
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO 3,4-dichloroaniline results in increased expression of HSPA6 mRNA CTD PMID:24172598 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO 3,4-dichloroaniline results in increased expression of MAF mRNA CTD PMID:24172598 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Matn3 matrilin 3 decreases expression ISO 3,4-dichloroaniline results in decreased expression of MATN3 mRNA CTD PMID:24172598 NCBI chr 6:34,071,428...34,091,048
Ensembl chr 6:34,071,428...34,091,048
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO 3,4-dichloroaniline results in increased expression of MCTP1 mRNA CTD PMID:24172598 NCBI chr 2:3,400,883...4,089,949
Ensembl chr 2:3,400,977...4,088,989
JBrowse link
G Mex3b mex-3 RNA binding family member B increases expression EXP 3,4-dichloroaniline results in increased expression of MEX3B mRNA CTD PMID:24172598 NCBI chr 1:144,831,523...144,835,758
Ensembl chr 1:144,831,523...144,835,747
JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 increases expression ISO 3,4-dichloroaniline results in increased expression of MICAL2 mRNA CTD PMID:24172598 NCBI chr 1:177,048,607...177,173,729
Ensembl chr 1:177,048,655...177,173,995
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO 3,4-dichloroaniline results in increased expression of MMP1 mRNA CTD PMID:24172598 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO 3,4-dichloroaniline results in increased expression of MMP10 mRNA CTD PMID:24172598 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP 3,4-dichloroaniline results in increased expression of MMP13 mRNA CTD PMID:24172598 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP 3,4-dichloroaniline results in increased expression of MMP3 mRNA CTD PMID:24172598 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline CTD PMID:20199096 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msrb3 methionine sulfoxide reductase B3 decreases expression ISO 3,4-dichloroaniline results in decreased expression of MSRB3 mRNA CTD PMID:24172598 NCBI chr 7:62,850,506...62,972,487
Ensembl chr 7:62,850,515...62,972,084
JBrowse link
G Muc1 mucin 1, cell surface associated increases expression ISO 3,4-dichloroaniline results in increased expression of MUC1 mRNA CTD PMID:24172598 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Muc16 mucin 16, cell surface associated increases expression ISO 3,4-dichloroaniline results in increased expression of MUC16 mRNA CTD PMID:24172598 NCBI chr 8:18,438,838...18,639,777 JBrowse link
G Myo10 myosin X increases expression ISO 3,4-dichloroaniline results in increased expression of MYO10 mRNA CTD PMID:24172598 NCBI chr 2:77,868,398...78,072,443
Ensembl chr 2:77,868,412...78,071,309
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of 3,4-dichloroaniline CTD PMID:15627487 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO 3,4-dichloroaniline results in increased expression of NDRG1 mRNA CTD PMID:24172598 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression
increases expression
ISO
EXP
3,4-dichloroaniline results in decreased expression of NEDD9 mRNA
3,4-dichloroaniline results in increased expression of NEDD9 mRNA
CTD PMID:24172598 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO 3,4-dichloroaniline results in increased expression of NT5E mRNA CTD PMID:24172598 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of NUSAP1 mRNA CTD PMID:24172598 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression ISO 3,4-dichloroaniline results in increased expression of OSTM1 mRNA CTD PMID:24172598 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
JBrowse link
G Pappa1 pappalysin 1 increases expression ISO 3,4-dichloroaniline results in increased expression of PAPPA mRNA CTD PMID:24172598 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO 3,4-dichloroaniline results in increased expression of PDK4 mRNA CTD PMID:24172598 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pgbd5 piggyBac transposable element derived 5 increases expression ISO 3,4-dichloroaniline results in increased expression of PGBD5 mRNA CTD PMID:24172598 NCBI chr19:57,126,110...57,192,182
Ensembl chr19:57,127,054...57,192,095
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO 3,4-dichloroaniline results in increased expression of PLAUR mRNA CTD PMID:24172598 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pld5 phospholipase D family, member 5 increases expression ISO 3,4-dichloroaniline results in increased expression of PLD5 mRNA CTD PMID:24172598 NCBI chr13:94,025,696...94,355,219
Ensembl chr13:94,025,369...94,355,219
JBrowse link
G Plk2 polo-like kinase 2 decreases expression ISO 3,4-dichloroaniline results in decreased expression of PLK2 mRNA CTD PMID:24172598 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Prdm1 PR/SET domain 1 increases expression ISO 3,4-dichloroaniline results in increased expression of PRDM1 mRNA CTD PMID:24172598 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Prnp prion protein decreases expression ISO 3,4-dichloroaniline results in decreased expression of PRNP mRNA CTD PMID:24172598 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Prss23 serine protease 23 increases expression EXP 3,4-dichloroaniline results in increased expression of PRSS23 mRNA CTD PMID:24172598 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO 3,4-dichloroaniline results in decreased expression of PTGER4 mRNA CTD PMID:24172598 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 3,4-dichloroaniline results in increased expression of PTGS2 mRNA CTD PMID:24172598 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of PTPRZ1 mRNA CTD PMID:24172598 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Ralbp1 ralA binding protein 1 increases expression ISO 3,4-dichloroaniline results in increased expression of RALBP1 mRNA CTD PMID:24172598 NCBI chr 9:113,579,107...113,598,477
Ensembl chr 9:113,579,107...113,598,480
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO 3,4-dichloroaniline results in increased expression of RARRES1 mRNA CTD PMID:24172598 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 increases expression ISO 3,4-dichloroaniline results in increased expression of RBCK1 mRNA CTD PMID:24172598 NCBI chr 3:147,793,014...147,809,941
Ensembl chr 3:147,793,017...147,809,919
JBrowse link
G RGD1305347 similar to RIKEN cDNA 2610528J11 increases expression ISO 3,4-dichloroaniline results in increased expression of C1ORF210 mRNA CTD PMID:24172598 NCBI chr 5:137,356,777...137,360,636
Ensembl chr 5:137,356,801...137,360,580
JBrowse link
G Rnf128 ring finger protein 128 increases expression EXP 3,4-dichloroaniline results in increased expression of RNF128 mRNA CTD PMID:24172598 NCBI chr  X:110,789,061...110,877,964
Ensembl chr  X:110,789,269...110,877,978
JBrowse link
G Rora RAR-related orphan receptor A increases expression ISO 3,4-dichloroaniline results in increased expression of RORA mRNA CTD PMID:24172598 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO 3,4-dichloroaniline results in increased expression of SCD mRNA CTD PMID:24172598 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scg5 secretogranin V increases expression ISO 3,4-dichloroaniline results in increased expression of SCG5 mRNA CTD PMID:24172598 NCBI chr 3:105,235,065...105,279,475
Ensembl chr 3:105,235,050...105,279,462
JBrowse link
G Scrn1 secernin 1 decreases expression EXP 3,4-dichloroaniline results in decreased expression of SCRN1 mRNA CTD PMID:24172598 NCBI chr 4:84,678,978...84,740,701
Ensembl chr 4:84,678,975...84,740,909
JBrowse link
G Serpinb2 serpin family B member 2 increases expression
decreases expression
ISO
EXP
3,4-dichloroaniline results in increased expression of SERPINB2 mRNA
3,4-dichloroaniline results in decreased expression of SERPINB2 mRNA
CTD PMID:24172598 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression ISO 3,4-dichloroaniline results in increased expression of SLC16A6 mRNA CTD PMID:24172598 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
JBrowse link
G Slc1a6 solute carrier family 1 member 6 decreases expression ISO 3,4-dichloroaniline results in decreased expression of SLC1A6 mRNA CTD PMID:24172598 NCBI chr 7:13,730,101...13,758,170
Ensembl chr 7:13,730,253...13,751,271
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO 3,4-dichloroaniline results in increased expression of SLCO4A1 mRNA CTD PMID:24172598 NCBI chr 3:175,838,994...175,857,985
Ensembl chr 3:175,838,994...175,857,983
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression EXP 3,4-dichloroaniline results in increased expression of SMPD3 mRNA CTD PMID:24172598 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sohlh2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 decreases expression ISO 3,4-dichloroaniline results in decreased expression of SOHLH2 mRNA CTD PMID:24172598 NCBI chr 2:144,591,755...144,614,065
Ensembl chr 2:144,591,755...144,614,064
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A decreases expression ISO 3,4-dichloroaniline results in decreased expression of SOWAHA mRNA CTD PMID:24172598 NCBI chr10:38,836,158...38,838,932
Ensembl chr10:38,836,614...38,838,272
JBrowse link
G Spc24 SPC24 component of NDC80 kinetochore complex decreases expression ISO 3,4-dichloroaniline results in decreased expression of SPC24 mRNA CTD PMID:24172598 NCBI chr 8:22,780,639...22,785,908
Ensembl chr 8:22,780,725...22,785,671
JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 increases expression EXP 3,4-dichloroaniline results in increased expression of ST6GAL1 mRNA CTD PMID:24172598 NCBI chr11:80,927,601...80,981,424
Ensembl chr11:80,927,601...80,981,422
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO 3,4-dichloroaniline results in decreased expression of STAR mRNA CTD PMID:31100596 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases expression EXP 3,4-dichloroaniline results in increased expression of SULT1B1 mRNA CTD PMID:24172598 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Sun3 Sad1 and UNC84 domain containing 3 increases expression ISO 3,4-dichloroaniline results in increased expression of SUN3 mRNA CTD PMID:24172598 NCBI chr14:89,215,386...89,253,585
Ensembl chr14:89,215,703...89,238,094
JBrowse link
G Taf9b TATA-box binding protein associated factor 9b decreases expression ISO 3,4-dichloroaniline results in decreased expression of TAF9B mRNA CTD PMID:24172598 NCBI chr  X:77,281,234...77,295,238
Ensembl chr  X:77,281,210...77,295,426
JBrowse link
G Tent5b terminal nucleotidyltransferase 5B decreases expression ISO 3,4-dichloroaniline results in decreased expression of TENT5B mRNA CTD PMID:24172598 NCBI chr 5:151,692,068...151,699,381
Ensembl chr 5:151,692,108...151,700,246
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression EXP 3,4-dichloroaniline results in decreased expression of TGFBI mRNA CTD PMID:24172598 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO 3,4-dichloroaniline results in increased expression of TIMP1 mRNA CTD PMID:24172598 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO 3,4-dichloroaniline results in increased expression of TMCC3 mRNA CTD PMID:24172598 NCBI chr 7:35,266,953...35,543,770
Ensembl chr 7:35,309,265...35,543,759
JBrowse link
G Tmem117 transmembrane protein 117 increases expression ISO 3,4-dichloroaniline results in increased expression of TMEM117 mRNA CTD PMID:24172598 NCBI chr 7:135,880,294...136,403,012
Ensembl chr 7:136,182,224...136,403,012
JBrowse link
G Tmem154 transmembrane protein 154 increases expression ISO 3,4-dichloroaniline results in increased expression of TMEM154 mRNA CTD PMID:24172598 NCBI chr 2:183,674,361...183,714,232
Ensembl chr 2:183,674,522...183,711,812
JBrowse link
G Tmem40 transmembrane protein 40 decreases expression ISO 3,4-dichloroaniline results in decreased expression of TMEM40 mRNA CTD PMID:24172598 NCBI chr 4:147,645,333...147,657,847
Ensembl chr 4:147,645,333...147,657,847
JBrowse link
G Tnfaip8l1 TNF alpha induced protein 8 like 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of TNFAIP8L1 mRNA CTD PMID:24172598 NCBI chr 9:10,894,949...10,905,647
Ensembl chr 9:10,896,680...10,897,240
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 increases expression ISO 3,4-dichloroaniline results in increased expression of TNFRSF10D mRNA CTD PMID:24172598 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tnfsf13b TNF superfamily member 13b increases expression ISO 3,4-dichloroaniline results in increased expression of TNFSF13B mRNA CTD PMID:24172598 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366
JBrowse link
G Tp63 tumor protein p63 decreases expression EXP 3,4-dichloroaniline results in decreased expression of TP63 mRNA CTD PMID:24172598 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tprg1 tumor protein p63 regulated 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of TPRG1 mRNA CTD PMID:24172598 NCBI chr11:78,733,046...78,861,745
Ensembl chr11:78,728,128...78,861,716
JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression EXP 3,4-dichloroaniline results in decreased expression of TRIB3 mRNA CTD PMID:24172598 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim59 tripartite motif-containing 59 decreases expression ISO 3,4-dichloroaniline results in decreased expression of TRIM59 mRNA CTD PMID:24172598 NCBI chr 2:165,629,903...165,641,751
Ensembl chr 2:165,629,918...165,641,573
JBrowse link
G Trim6 tripartite motif containing 6 decreases expression ISO 3,4-dichloroaniline results in decreased expression of TRIM6 mRNA CTD PMID:24172598 NCBI chr 1:169,410,084...169,423,305
Ensembl chr 1:169,410,115...169,423,283
JBrowse link
G Ubd ubiquitin D increases expression EXP 3,4-dichloroaniline results in increased expression of UBD mRNA CTD PMID:24172598 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Vgll1 vestigial-like family member 1 decreases expression ISO 3,4-dichloroaniline results in decreased expression of VGLL1 mRNA CTD PMID:24172598 NCBI chr  X:159,556,296...159,576,639 JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 increases expression ISO 3,4-dichloroaniline results in increased expression of ZBTB1 mRNA CTD PMID:24172598 NCBI chr 6:99,401,775...99,425,739
Ensembl chr 6:99,402,360...99,424,019
JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 decreases expression EXP 3,4-dichloroaniline results in decreased expression of ZC3H13 mRNA CTD PMID:24172598 NCBI chr15:57,340,522...57,405,287
Ensembl chr15:57,340,579...57,405,287
JBrowse link
clonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP
Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
increases response to substance
ISO
EXP
Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine
CTD PMID:8987795 PMID:10217548 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Avp arginine vasopressin increases expression EXP Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp2 caspase 2 increases activity ISO Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
EXP
ISO
Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein
CTD PMID:15351510 PMID:28115640 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing
ISO [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine CTD PMID:31585114 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gal galanin and GMAP prepropeptide increases activity EXP Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions
increases expression
ISO
EXP
Clonidine results in increased secretion of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gnai1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifng interferon gamma multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases secretion ISO Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD PMID:12065299 PMID:16192389 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Ins2 insulin 2 decreases secretion ISO Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y increases expression
multiple interactions
decreases expression
EXP Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD PMID:1878751 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases response to substance
EXP [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine
CTD PMID:8987795 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression
ISO
EXP
Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prl prolactin increases expression
multiple interactions
ISO
EXP
Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD PMID:1678730 PMID:16401171 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases activity
decreases activity
decreases expression
multiple interactions
ISO Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
clonidine (amino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP
Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
increases response to substance
ISO
EXP
Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine
CTD PMID:8987795 PMID:10217548 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Avp arginine vasopressin increases expression EXP Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp2 caspase 2 increases activity ISO Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
EXP
ISO
Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein
CTD PMID:15351510 PMID:28115640 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD PMID:31585114 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gal galanin and GMAP prepropeptide increases activity EXP Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions
increases expression
ISO
EXP
Clonidine results in increased secretion of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gnai1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifng interferon gamma multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases secretion ISO Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD PMID:12065299 PMID:16192389 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Ins2 insulin 2 decreases secretion ISO Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y increases expression
multiple interactions
decreases expression
EXP Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD PMID:1878751 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases response to substance
EXP [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine
CTD PMID:8987795 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression
ISO
EXP
Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prl prolactin increases expression
multiple interactions
ISO
EXP
Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD PMID:1678730 PMID:16401171 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases activity
decreases activity
decreases expression
multiple interactions
ISO Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
clonidine (imino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP
Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
increases response to substance
ISO
EXP
Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine
CTD PMID:8987795 PMID:10217548 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Avp arginine vasopressin increases expression EXP Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp2 caspase 2 increases activity ISO Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
EXP
ISO
Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein
CTD PMID:15351510 PMID:28115640 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD PMID:31585114 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gal galanin and GMAP prepropeptide increases activity EXP Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions
increases expression
ISO
EXP
Clonidine results in increased secretion of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gnai1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifng interferon gamma multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases secretion ISO Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD PMID:12065299 PMID:16192389 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Ins2 insulin 2 decreases secretion ISO Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y increases expression
multiple interactions
decreases expression
EXP Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD PMID:1878751 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases response to substance
EXP [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine
CTD PMID:8987795 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression
ISO
EXP
Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prl prolactin increases expression
multiple interactions
ISO
EXP
Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD PMID:1678730 PMID:16401171 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases activity
decreases activity
decreases expression
multiple interactions
ISO Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
propanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Propanil binds to and results in increased activity of AHR protein CTD PMID:18835618 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Propanil binds to AR protein
Dihydrotestosterone inhibits the reaction [Propanil results in increased activity of AR protein]
CTD PMID:14565775 PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Propanil results in increased expression of DNAJB1 mRNA CTD PMID:24356939 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Propanil results in decreased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Propanil results in increased expression of HSPA1B mRNA CTD PMID:24356939 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Propanil results in decreased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifng interferon gamma multiple interactions ISO Lipopolysaccharides promotes the reaction [Propanil results in increased expression of IFNG mRNA]; Lipopolysaccharides promotes the reaction [Propanil results in increased expression of IFNG protein] CTD PMID:7679225 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases stability
ISO Propanil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Propanil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein]
Propanil results in decreased stability of IL2 mRNA
CTD PMID:9925799 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion
ISO Propanil promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Propanil results in decreased secretion of IL6 protein
CTD PMID:9201266 PMID:9221836 PMID:17585980 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Propanil inhibits the reaction [[NFKB1 protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter] CTD PMID:11312646 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17355946 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:11312646 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sqle squalene epoxidase decreases expression ISO Propanil results in decreased expression of SQLE mRNA CTD PMID:24356939 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
decreases secretion
multiple interactions
ISO Propanil results in decreased expression of TNF protein
Propanil results in increased expression of TNF protein
Propanil results in decreased secretion of TNF protein
Lipopolysaccharides promotes the reaction [Propanil results in increased expression of TNF protein]; Propanil inhibits the reaction [[NFKB1 protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:7679225 PMID:9201266 PMID:9221836 PMID:11312646 PMID:17355946 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Zfp628 zinc finger protein 628 decreases expression ISO Propanil results in decreased expression of ZNF628 mRNA CTD PMID:24356939 NCBI chr 1:72,465,403...72,474,442
Ensembl chr 1:72,465,341...72,468,738
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      molecular entity 19766
        polyatomic entity 19685
          heteroatomic molecular entity 19615
            halide 18072
              organohalogen compound 17839
                organochlorine compound 17636
                  chlorobenzenes 13593
                    chloroaniline 226
                      dichloroaniline 213
                        2,3-dichloroaniline 0
                        2,4-dichloroaniline 1
                        2,5-dichloroaniline 0
                        2,6-dichloroaniline + 51
                        3,4-dichloroaniline + 167
                        3,5-dichloroaniline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            inorganic hydride 17459
                              pnictogen hydride 17434
                                nitrogen hydride 17281
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        aromatic amine 13683
                                          anilines 12360
                                            substituted aniline 11856
                                              chloroaniline 226
                                                dichloroaniline 213
                                                  2,3-dichloroaniline 0
                                                  2,4-dichloroaniline 1
                                                  2,5-dichloroaniline 0
                                                  2,6-dichloroaniline + 51
                                                  3,4-dichloroaniline + 167
                                                  3,5-dichloroaniline 0
paths to the root