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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:defoliant
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Accession:CHEBI:23582 term browser browse the term
Definition:A herbicide which when sprayed or dusted on plants causes its leaves to fall off.
Synonyms:related_synonym: Defoliationsmittel;   Entlaubungsmittel;   defoliants


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(2,4,5-trichlorophenoxy)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNA CTD PMID:18579281 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA CTD PMID:9210621 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 protein
Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA]
CTD PMID:10377250, PMID:16426233 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACAP3 mRNA CTD PMID:18579281 NCBI chr 5:173,340,060...173,354,756
Ensembl chr 5:173,340,060...173,354,755
JBrowse link
G Acer2 alkaline ceramidase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACER2 mRNA CTD PMID:18579281 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731
JBrowse link
G Adgrb2 adhesion G protein-coupled receptor B2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADGRB2 mRNA CTD PMID:18579281 NCBI chr 5:148,168,530...148,231,587
Ensembl chr 5:148,193,710...148,231,587
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA CTD PMID:18579281 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Alpi alkaline phosphatase, intestinal decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ALPI mRNA CTD PMID:18579281 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Ar androgen receptor affects binding EXP 2,4,5-Trichlorophenoxyacetic Acid binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arhgap32 Rho GTPase activating protein 32 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARHGAP32 mRNA CTD PMID:18579281 NCBI chr 8:33,131,874...33,392,198
Ensembl chr 8:33,239,139...33,392,305
JBrowse link
G Arsg arylsulfatase G increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARSG mRNA CTD PMID:18579281 NCBI chr10:97,722,550...97,859,975
Ensembl chr10:97,771,264...97,863,311
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of BASP1 mRNA CTD PMID:18579281 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
JBrowse link
G C1qtnf4 C1q and TNF related 4 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of C1QTNF4 mRNA CTD PMID:18579281 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CACNB3 mRNA CTD PMID:18579281 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CAMK1D mRNA CTD PMID:18579281 NCBI chr17:76,532,611...76,938,956
Ensembl chr17:76,532,611...76,938,956
JBrowse link
G Capn6 calpain 6 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CAPN6 mRNA CTD PMID:18579281 NCBI chr  X:115,049,113...115,073,824
Ensembl chr  X:115,049,154...115,073,890
JBrowse link
G Cdh1 cadherin 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CDH1 mRNA CTD PMID:18579281 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CIRBP mRNA CTD PMID:18579281 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Ckm creatine kinase, M-type increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CKM mRNA CTD PMID:18579281 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of COL15A1 mRNA CTD PMID:18579281 NCBI chr 5:62,840,360...62,950,240 JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP7B1 mRNA CTD PMID:18579281 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Ddc dopa decarboxylase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of DDC mRNA CTD PMID:18579281 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of EEPD1 mRNA CTD PMID:18579281 NCBI chr 8:26,651,241...26,758,330
Ensembl chr 8:26,652,121...26,758,325
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased activity of EPHX1 protein CTD PMID:3032197 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of and results in increased activity of EPHX2 protein CTD PMID:3032197 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 2,4,5-Trichlorophenoxyacetic Acid binds to and results in decreased activity of ESR1 protein CTD PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Far1 fatty acyl CoA reductase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FAR1 mRNA CTD PMID:18579281 NCBI chr 1:178,351,674...178,412,838
Ensembl chr 1:178,351,680...178,431,395
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FKBP5 mRNA CTD PMID:18579281 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FMO2 mRNA CTD PMID:18579281 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G G0s2 G0/G1switch 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of G0S2 mRNA CTD PMID:18579281 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBF1 mRNA CTD PMID:18579281 NCBI chr 1:265,904,616...266,033,107
Ensembl chr 1:265,904,566...266,033,156
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA
CTD PMID:10377250, PMID:16426233 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GDE1 mRNA CTD PMID:18579281 NCBI chr 1:188,367,550...188,407,125
Ensembl chr 1:188,394,814...188,407,132
JBrowse link
G Gfra1 GDNF family receptor alpha 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GFRA1 mRNA CTD PMID:18579281 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Git2 GIT ArfGAP 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GIT2 mRNA CTD PMID:18579281 NCBI chr12:47,590,110...47,630,991
Ensembl chr12:47,590,154...47,631,119
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GMPPB mRNA CTD PMID:18579281 NCBI chr 8:116,826,251...116,856,159
Ensembl chr 8:116,826,680...116,856,159
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GOT1 mRNA CTD PMID:18579281 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpm6a glycoprotein m6a decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPM6A mRNA CTD PMID:18579281 NCBI chr16:39,367,697...39,719,292
Ensembl chr16:39,367,692...39,719,187
JBrowse link
G Gpr12 G protein-coupled receptor 12 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GPR12 mRNA CTD PMID:18579281 NCBI chr12:10,253,710...10,257,135
Ensembl chr12:10,254,951...10,257,130
JBrowse link
G Gpr85 G protein-coupled receptor 85 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPR85 mRNA CTD PMID:18579281 NCBI chr 4:40,377,705...40,387,147
Ensembl chr 4:40,381,685...40,385,349
JBrowse link
G Hapln1 hyaluronan and proteoglycan link protein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HAPLN1 mRNA CTD PMID:18579281 NCBI chr 2:18,354,542...18,419,077
Ensembl chr 2:18,354,542...18,419,071
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HMOX1 mRNA CTD PMID:18579281 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPA8 mRNA CTD PMID:18579281 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPB1 mRNA CTD PMID:18579281 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPH1 mRNA CTD PMID:18579281 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IDO2 mRNA CTD PMID:18579281 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IHH mRNA CTD PMID:18579281 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IKBKE mRNA CTD PMID:18579281 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of IL1R1 mRNA CTD PMID:18579281 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Insc INSC, spindle orientation adaptor protein increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of INSC mRNA CTD PMID:18579281 NCBI chr 1:184,299,200...184,407,487
Ensembl chr 1:184,299,250...184,407,480
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of KLF5 mRNA CTD PMID:18579281 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Limch1 LIM and calponin homology domains 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LIMCH1 mRNA CTD PMID:18579281 NCBI chr14:42,760,363...43,072,976
Ensembl chr14:42,762,587...43,072,843
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LMCD1 mRNA CTD PMID:18579281 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G LOC102547963 leucine-rich repeat and transmembrane domain-containing protein 1-like increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA CTD PMID:18579281 NCBI chr16:5,078,506...5,089,888
Ensembl chr16:5,082,239...5,087,844
JBrowse link
G LOC103690086 uncharacterized LOC103690086 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBP9 mRNA CTD PMID:18579281 NCBI chr14:5,642,357...5,646,406 JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPAR4 mRNA CTD PMID:18579281 NCBI chr  X:78,042,859...78,056,347
Ensembl chr  X:78,042,859...78,056,347
JBrowse link
G Lpin1 lipin 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPIN1 mRNA CTD PMID:18579281 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Lrtm1 leucine-rich repeats and transmembrane domains 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA CTD PMID:18579281 NCBI chr16:4,993,728...5,005,110
Ensembl chr16:4,997,461...5,003,066
JBrowse link
G Matk megakaryocyte-associated tyrosine kinase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MATK mRNA CTD PMID:18579281 NCBI chr 7:11,325,246...11,334,311
Ensembl chr 7:11,325,254...11,330,278
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MPDZ mRNA CTD PMID:18579281 NCBI chr 5:99,413,184...99,566,356
Ensembl chr 5:99,413,187...99,566,318
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT1 mRNA CTD PMID:18579281 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt4 metallothionein 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT4 mRNA CTD PMID:18579281 NCBI chr19:11,339,767...11,341,863
Ensembl chr19:11,339,767...11,341,863
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MVD mRNA CTD PMID:18579281 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mybph myosin binding protein H increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MYBPH mRNA CTD PMID:18579281 NCBI chr13:51,034,228...51,041,903
Ensembl chr13:51,034,256...51,041,902
JBrowse link
G Ndrg4 NDRG family member 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NDRG4 mRNA CTD PMID:18579281 NCBI chr19:9,766,439...9,802,396
Ensembl chr19:9,766,439...9,801,942
JBrowse link
G Nip7 nucleolar pre-rRNA processing protein NIP7 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NIP7 mRNA CTD PMID:18579281 NCBI chr19:39,257,586...39,259,728
Ensembl chr19:39,257,586...39,259,728
JBrowse link
G Nrg4 neuregulin 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NRG4 mRNA CTD PMID:18579281 NCBI chr 8:59,782,789...59,849,433
Ensembl chr 8:59,782,974...59,849,490
JBrowse link
G Ogn osteoglycin decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of OGN mRNA CTD PMID:18579281 NCBI chr17:14,607,442...14,628,274
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359
JBrowse link
G Olr346 olfactory receptor 346 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of OLFR1451 mRNA CTD PMID:18579281 NCBI chr 1:229,849,892...229,850,818
Ensembl chr 1:229,849,892...229,850,818
JBrowse link
G Pdzd3 PDZ domain containing 3 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PDZD3 mRNA CTD PMID:18579281 NCBI chr 8:48,577,905...48,582,353
Ensembl chr 8:48,577,952...48,582,353
JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PFKP mRNA CTD PMID:18579281 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Plin4 perilipin 4 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PLIN4 mRNA CTD PMID:18579281 NCBI chr 9:10,963,494...10,972,360
Ensembl chr 9:10,963,723...10,971,277
JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of POR mRNA CTD PMID:18579281 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppfibp1 PPFIA binding protein 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPFIBP1 mRNA CTD PMID:18579281 NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157
JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA CTD PMID:18579281 NCBI chr 4:41,171,486...41,212,116
Ensembl chr 4:41,171,486...41,212,072
JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3G mRNA CTD PMID:18579281 NCBI chr17:29,566,032...29,570,294
Ensembl chr17:29,567,404...29,568,447
JBrowse link
G Prok1 prokineticin 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of PROK1 mRNA CTD PMID:18579281 NCBI chr 2:209,986,503...209,994,438
Ensembl chr 2:209,987,992...209,993,250
JBrowse link
G Prr9 proline rich 9 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PRR9 mRNA CTD PMID:18579281 NCBI chr 2:192,025,457...192,036,073
Ensembl chr 2:192,025,875...192,027,225
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PTP4A1 mRNA CTD PMID:18579281 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Retreg1 reticulophagy regulator 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RETREG1 mRNA CTD PMID:18579281 NCBI chr 2:78,391,921...78,401,569
Ensembl chr 2:78,391,921...78,399,987
JBrowse link
G Rprd1a regulation of nuclear pre-mRNA domain containing 1A decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RPRD1A mRNA CTD PMID:18579281 NCBI chr18:16,450,160...16,497,913
Ensembl chr18:16,453,369...16,497,886
JBrowse link
G Selenop selenoprotein P decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SELENOP mRNA CTD PMID:18579281 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Sema3c semaphorin 3C decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SEMA3C mRNA CTD PMID:18579281 NCBI chr 4:14,318,276...14,490,438
Ensembl chr 4:14,318,274...14,490,446
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SGK2 mRNA CTD PMID:18579281 NCBI chr 3:159,361,313...159,385,843
Ensembl chr 3:159,368,273...159,384,775
JBrowse link
G Slc24a2 solute carrier family 24 member 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC24A2 mRNA CTD PMID:18579281 NCBI chr 5:105,336,287...105,579,959
Ensembl chr 5:105,336,262...105,582,375
JBrowse link
G Slc25a32 solute carrier family 25 member 32 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC25A32 mRNA CTD PMID:18579281 NCBI chr 7:77,983,885...78,005,058
Ensembl chr 7:77,987,212...78,004,975
JBrowse link
G Slc66a1 solute carrier family 66 member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC66A1 mRNA CTD PMID:18579281 NCBI chr 5:157,744,945...157,759,370
Ensembl chr 5:157,745,490...157,759,322
JBrowse link
G Slc6a15 solute carrier family 6 member 15 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC6A15 mRNA CTD PMID:18579281 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Snx7 sorting nexin 7 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SNX7 mRNA CTD PMID:18579281 NCBI chr 2:221,015,302...221,099,810
Ensembl chr 2:221,015,310...221,099,738
JBrowse link
G Spon2 spondin 2 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SPON2 mRNA CTD PMID:18579281 NCBI chr14:82,815,158...82,824,529
Ensembl chr14:82,818,663...82,824,599
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SREBF1 mRNA CTD PMID:18579281 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Svil supervillin increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SVIL mRNA CTD PMID:18579281 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Tacc2 transforming, acidic coiled-coil containing protein 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TACC2 mRNA CTD PMID:18579281 NCBI chr 1:201,140,264...201,329,612
Ensembl chr 1:201,055,644...201,329,622
JBrowse link
G Tbc1d8 TBC1 domain family, member 8 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TBC1D8 mRNA CTD PMID:18579281 NCBI chr 9:46,090,613...46,206,672
Ensembl chr 9:46,090,019...46,206,605
JBrowse link
G Tcea2 transcription elongation factor A2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TCEA2 mRNA CTD PMID:18579281 NCBI chr 3:177,187,686...177,195,898
Ensembl chr 3:177,188,044...177,195,894
JBrowse link
G Thra thyroid hormone receptor alpha increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of THRA mRNA CTD PMID:18579281 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2,4,5-Trichlorophenoxyacetic Acid binds to THRB protein CTD PMID:27410513 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tom1l2 target of myb1 like 2 membrane trafficking protein decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TOM1L2 mRNA CTD PMID:18579281 NCBI chr10:46,599,392...46,720,921
Ensembl chr10:46,602,231...46,720,910
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TRIB3 mRNA CTD PMID:18579281 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tril TLR4 interactor with leucine-rich repeats decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TRIL mRNA CTD PMID:18579281 NCBI chr 4:83,967,695...83,972,540
Ensembl chr 4:83,967,696...83,972,540
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TSC22D1 mRNA CTD PMID:18579281 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of UGT2A3 mRNA CTD PMID:18579281 NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of USP2 mRNA CTD PMID:18579281 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VCAM1 mRNA CTD PMID:18579281 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Veph1 ventricular zone expressed PH domain-containing 1 increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of VEPH1 mRNA CTD PMID:18579281 NCBI chr 2:157,869,383...158,156,266
Ensembl chr 2:157,869,392...158,156,444
JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) increases expression ISO 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of WARS2 mRNA CTD PMID:18579281 NCBI chr 2:201,170,363...201,256,115
Ensembl chr 2:201,172,312...201,255,703
JBrowse link
2,4-D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA CTD PMID:9210621 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Alb albumin affects binding ISO 2,4-Dichlorophenoxyacetic Acid binds to ALB protein CTD PMID:9877224, PMID:11451446 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Androgens binds to AR protein]; 2,4-Dichlorophenoxyacetic Acid promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein] CTD PMID:16107550 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccdc120 coiled-coil domain containing 120 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CCDC120 mRNA CTD PMID:15878651 NCBI chr  X:15,610,230...15,616,727
Ensembl chr  X:15,598,652...15,617,665
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 protein CTD PMID:19467290 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL2 protein CTD PMID:19467290 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL4 protein CTD PMID:19467290 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cldn1 claudin 1 decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 protein CTD PMID:28699141 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Clk1 CDC-like kinase 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLK1 mRNA CTD PMID:15878651 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CNP protein CTD PMID:18460445 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Crat carnitine O-acetyltransferase increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of CRAT protein CTD PMID:1755024 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects expression ISO 2,4-Dichlorophenoxyacetic Acid affects the expression of CYP17A1 mRNA CTD PMID:26838045 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A1 mRNA CTD PMID:10910964 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A2 mRNA CTD PMID:10910964 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1B1 mRNA CTD PMID:10910964 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Dbh dopamine beta-hydroxylase decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH protein CTD PMID:16931444 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Dclre1c DNA cross-link repair 1C increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of DCLRE1C mRNA CTD PMID:15878651 NCBI chr17:78,782,512...78,812,140
Ensembl chr17:78,783,437...78,812,111
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of DDB2 mRNA CTD PMID:15878651 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX1 protein CTD PMID:3032197 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 increases activity ISO 2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX2 protein CTD PMID:1755024, PMID:3032197 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of FTH1 mRNA CTD PMID:15878651 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of FTL mRNA CTD PMID:15878651 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR CTD PMID:26838045 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCS1 CTD PMID:26838045 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Ifng interferon gamma increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IFNG CTD PMID:20728597 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of IL1RL1 mRNA CTD PMID:15878651 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il2 interleukin 2 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2 CTD PMID:20728597 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2RA CTD PMID:20728597 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein
2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein
CTD PMID:19467290 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL5 protein CTD PMID:19467290 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL6 protein CTD PMID:19467290 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ldha lactate dehydrogenase A decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA protein CTD PMID:23538319 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Mbp myelin basic protein decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of MBP protein CTD PMID:18460445 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation ISO 2,4-Dichlorophenoxyacetic Acid results in decreased methylation of MYC promoter CTD PMID:11857776 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ocln occludin decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of OCLN mRNA CTD PMID:28699141 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases secretion EXP 2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein CTD PMID:20122984 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of PCNA mRNA CTD PMID:15878651 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pfkm phosphofructokinase, muscle decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM protein CTD PMID:23538319 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases response to substance ISO PPARA protein results in increased susceptibility to 2,4-Dichlorophenoxyacetic Acid CTD PMID:26838045 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prl prolactin decreases secretion EXP 2,4-Dichlorophenoxyacetic Acid results in decreased secretion of PRL protein CTD PMID:20122984 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNA CTD PMID:15878651 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Slc16a3 solute carrier family 16 member 3 decreases expression
increases expression
EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC16A3 mRNA
2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC16A3 mRNA
CTD PMID:23538319 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid] CTD PMID:15284287 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:221,327,608...221,344,367
Ensembl chr 1:221,328,711...221,343,889
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake
multiple interactions
EXP
ISO
SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid
p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]
CTD PMID:16857889, PMID:17255469 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression
increases expression
EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 protein
2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC2A3 mRNA
CTD PMID:23538319 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Th tyrosine hydroxylase increases expression EXP 2,4-Dichlorophenoxyacetic Acid results in increased expression of TH protein CTD PMID:16931444 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO 2,4-Dichlorophenoxyacetic Acid binds to THRB protein CTD PMID:27410513 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 protein CTD PMID:28699141 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF CTD PMID:20728597 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Usp19 ubiquitin specific peptidase 19 increases expression ISO 2,4-Dichlorophenoxyacetic Acid results in increased expression of USP19 mRNA CTD PMID:15878651 NCBI chr 8:117,280,690...117,291,729
Ensembl chr 8:117,280,705...117,291,351
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO 2,4-Dichlorophenoxyacetic Acid results in decreased expression of VEGFA mRNA CTD PMID:15878651 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
diquat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO Diquat results in increased expression of ADM mRNA CTD PMID:21172416 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diquat results in increased expression of ADORA2B mRNA CTD PMID:21172416 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Diquat results in increased expression of AKR1B10 mRNA CTD PMID:21172416 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Diquat results in increased expression of AKR1C2 mRNA CTD PMID:21172416 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein] CTD PMID:20826540 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Diquat results in increased expression of ANKRD1 mRNA CTD PMID:21172416 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Diquat results in increased expression of ATF3 mRNA CTD PMID:21172416 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA CTD PMID:27057282 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
ISO procyanidin B2 affects the reaction [Diquat affects the expression of BAX mRNA] CTD PMID:26785375, PMID:27057282 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO
EXP
Diquat affects the expression of BCL2 mRNA
Diquat results in decreased expression of BCL2 protein
procyanidin B2 affects the reaction [Diquat affects the expression of BCL2 mRNA]
CTD PMID:26785375, PMID:27057282, PMID:29484840 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression
multiple interactions
ISO Diquat results in increased expression of BCL2L11 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of BCL2L11 mRNA]
CTD PMID:26785375, PMID:27057282 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA CTD PMID:27057282 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
ISO
EXP
GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; Meloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; SN50 peptide inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]
Diquat results in increased expression of CASP3 mRNA
Diquat results in increased expression of CASP3 mRNA; Diquat results in increased expression of CASP3 protein modified form
Diquat results in increased cleavage of and results in increased activity of CASP3 protein; procyanidin B2 inhibits the reaction [Diquat results in increased expression of CASP3 mRNA]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:15496407, PMID:18164269, PMID:19815060, PMID:26785375, PMID:27057282, PMID:29484840 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases cleavage
ISO
EXP
Diquat results in increased cleavage of and results in increased activity of CASP9 protein; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form]
CTD PMID:18164269, PMID:20826540, PMID:29484840 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]
Diquat results in decreased activity of CAT protein
CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]
CTD PMID:21215309, PMID:26785375, PMID:27057282 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases expression ISO Diquat results in increased expression of CLIP4 mRNA CTD PMID:21172416 NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP Diquat results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Diquat results in increased expression of CYP4A1 mRNA CTD PMID:7676460 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Diquat results in increased expression of DDIT3 mRNA; Diquat results in increased expression of DDIT3 protein
PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]
CTD PMID:20826540 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO Diquat results in increased expression of DKK1 mRNA CTD PMID:21172416 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Diquat results in increased expression of DUSP1 mRNA CTD PMID:21172416 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA] CTD PMID:20826540 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO Diquat results in increased expression of ELL2 mRNA CTD PMID:21172416 NCBI chr 2:2,456,189...2,525,590
Ensembl chr 2:2,456,735...2,524,237
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Diquat results in increased expression of FOS mRNA
PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]
CTD PMID:20826540 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
ISO Diquat results in increased expression of FOXO1 mRNA
procyanidin B2 inhibits the reaction [Diquat results in increased expression of FOXO1 mRNA]
CTD PMID:27057282 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP Diquat results in increased expression of FTH1 mRNA CTD PMID:21698372 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Diquat results in increased expression of FTL1 mRNA CTD PMID:16962985 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression
increases activity
EXP
ISO
Diquat results in increased expression of G6PD mRNA; Diquat results in increased expression of G6PD protein
Diquat results in increased activity of G6PD protein
CTD PMID:8934631, PMID:28108222 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Diquat results in increased expression of GADD45A mRNA CTD PMID:21172416 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
decreases activity
decreases expression
ISO
EXP
Diquat results in increased expression of GCLC mRNA
[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA
Diquat results in decreased activity of GCLC protein
Diquat results in decreased expression of GCLC mRNA
CTD PMID:7676460, PMID:16962985, PMID:22762311 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Diquat results in increased expression of GCLM mRNA CTD PMID:16962985, PMID:20826540, PMID:21172416 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glrx glutaredoxin increases response to substance ISO GLRX gene mutant form results in increased susceptibility to Diquat CTD PMID:17893043 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein] CTD PMID:15496407 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
decreases response to substance
affects response to substance
multiple interactions
increases response to substance
ISO Diquat results in decreased expression of GPX1 protein
GPX1 protein results in decreased susceptibility to Diquat
GPX1 protein affects the susceptibility to Diquat
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [Diquat results in increased abundance of F2-Isoprostanes]; GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein]
GPX1 gene mutant form results in increased susceptibility to Diquat; GPX1 protein results in increased susceptibility to Diquat
CTD PMID:10490281, PMID:11568445, PMID:11672444, PMID:15182862 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance
increases expression
multiple interactions
ISO GPX4 protein alternative form results in decreased susceptibility to Diquat
Diquat results in increased expression of GPX4 mRNA
GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein]; GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]
CTD PMID:15496407, PMID:16962985, PMID:19744930 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Diquat results in increased expression of GSR mRNA CTD PMID:16962985 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Diquat results in decreased expression of GSTA1 mRNA CTD PMID:7676460 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Diquat results in decreased expression of GSTA2 mRNA CTD PMID:7676460 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP Diquat results in decreased expression of GSTA3 mRNA CTD PMID:7676460 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Diquat results in decreased expression of GSTM1 mRNA CTD PMID:7676460 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Diquat results in decreased expression of GSTM2 mRNA CTD PMID:7676460 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP Diquat results in increased expression of HAMP mRNA CTD PMID:21698372 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity
multiple interactions
ISO Diquat results in increased expression of HMOX1 mRNA; Diquat results in increased expression of HMOX1 protein
Diquat results in increased activity of HMOX1 protein
PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]
CTD PMID:20826540, PMID:21172416 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Diquat results in increased expression of HSPA1A mRNA CTD PMID:21172416 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Diquat results in increased expression of HSPA1B mRNA CTD PMID:21172416 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ifng interferon gamma multiple interactions ISO Diquat promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide] CTD PMID:11498278 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases response to substance ISO IGF1R protein results in increased susceptibility to Diquat CTD PMID:22132081 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il6 interleukin 6 increases expression EXP Diquat results in increased expression of IL6 protein CTD PMID:21698372 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Diquat results in increased expression of JUN mRNA CTD PMID:21172416 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]; KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat] CTD PMID:22762311 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kynu kynureninase increases expression ISO Diquat results in increased expression of KYNU mRNA CTD PMID:21172416 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of MAP1LC3B mRNA CTD PMID:27057282 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO Diquat results in increased expression of MAP2 mRNA CTD PMID:21172416 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK1 protein CTD PMID:20826540 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Diquat results in increased phosphorylation of MAPK3 protein CTD PMID:20826540 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein] CTD PMID:20826540 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Me1 malic enzyme 1 increases expression ISO Diquat results in increased expression of ME1 mRNA CTD PMID:16962985 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP Capsaicin inhibits the reaction [Diquat results in increased activity of MPO protein] CTD PMID:15046732 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
ISO PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA] CTD PMID:20826540 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A decreases expression
multiple interactions
ISO Diquat results in decreased expression of MT2 mRNA
PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]
CTD PMID:20826540 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nefh neurofilament heavy affects expression EXP Diquat affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
increases response to substance
decreases response to substance
increases activity
multiple interactions
ISO Diquat results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Diquat
NFE2L2 results in decreased susceptibility to Diquat
Diquat results in increased activity of NFE2L2 protein
KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]
CTD PMID:16962985, PMID:20143881, PMID:20826540, PMID:21172416, PMID:22762311, PMID:23056183 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
increases activity
ISO Diquat results in increased expression of NQO1 mRNA
PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]
Diquat results in increased expression of NQO1 mRNA; Diquat results in increased expression of NQO1 protein
Diquat results in increased activity of NQO1 protein
CTD PMID:20826540, PMID:21172416 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Diquat results in increased cleavage of PARP1 protein CTD PMID:25693864 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Diquat results in increased expression of PGD mRNA CTD PMID:16962985 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO [Diquat co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNA CTD PMID:27057282 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases metabolic processing
ISO [[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [Iron co-treated with POR protein] results in increased metabolism of Diquat; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]; NADP promotes the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; POR protein results in increased metabolism of Diquat
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; Dimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]
[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP; [POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen; POR protein results in increased metabolism of Diquat
CTD PMID:21215309 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppif peptidylprolyl isomerase F increases expression ISO Diquat results in increased expression of PPIF mRNA CTD PMID:21172416 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Diquat results in increased expression of PPP1R15A mRNA CTD PMID:21172416 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Diquat results in increased expression of PRDX1 mRNA CTD PMID:16962985 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Diquat results in increased expression of PRDX3 mRNA CTD PMID:16962985 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prop1 PROP paired-like homeobox 1 decreases response to substance
affects response to substance
multiple interactions
ISO PROP1 gene mutant form results in decreased susceptibility to Diquat
PROP1 protein affects the susceptibility to Diquat
PROP1 protein affects the reaction [Diquat affects the phosphorylation of MAPK9 protein]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT1 mRNA]; PROP1 protein affects the reaction [Diquat results in decreased expression of MT2 mRNA]; PROP1 protein affects the reaction [Diquat results in increased cleavage of CASP9 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of DDIT3 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of EGR1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of FOS mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of HMOX1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein]; PROP1 protein affects the reaction [Diquat results in increased expression of NQO1 mRNA]; PROP1 protein affects the reaction [Diquat results in increased phosphorylation of AKT1 protein]
CTD PMID:19414510, PMID:20826540 NCBI chr10:36,449,920...36,452,381
Ensembl chr10:36,449,920...36,452,378
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Diquat results in increased expression of PTGS2 protein
Meloxicam inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of PTGS2 protein]
CTD PMID:29484840 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rasgef1b RasGEF domain family, member 1B increases expression ISO Diquat results in increased expression of RASGEF1B mRNA CTD PMID:21172416 NCBI chr14:11,499,692...12,028,513
Ensembl chr14:11,988,671...12,027,381
JBrowse link
G Rgs20 regulator of G-protein signaling 20 increases expression ISO Diquat results in increased expression of RGS20 mRNA CTD PMID:21172416 NCBI chr 5:14,367,498...14,494,048
Ensembl chr 5:14,415,606...14,494,756
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO Diquat results in increased expression of RGS4 mRNA CTD PMID:21172416 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO Diquat results in increased expression of RND3 mRNA CTD PMID:21172416 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Diquat results in increased expression of SAT1 mRNA CTD PMID:21172416 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO Diquat results in increased expression of SERPINB8 mRNA CTD PMID:21172416 NCBI chr13:27,876,662...27,914,038
Ensembl chr13:27,889,345...27,914,006
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Diquat results in increased expression of SERPINE1 mRNA CTD PMID:21172416 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression EXP Diquat results in decreased expression of SLC40A1 mRNA CTD PMID:21698372 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Diquat results in increased expression of SLC7A11 mRNA CTD PMID:21172416 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in decreased activity of SOD1 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
Diquat results in decreased expression of SOD1 mRNA
CTD PMID:7676460, PMID:11672444 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity
ISO
EXP
GPX1 protein affects the reaction [Diquat results in increased activity of SOD2 protein]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
Diquat results in increased expression of SOD2 protein
CTD PMID:11672444, PMID:29484840 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Diquat results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression ISO Diquat results in increased expression of SPINK1 mRNA CTD PMID:21172416 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Diquat results in increased expression of SRXN1 mRNA CTD PMID:21172416 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Diquat results in increased expression of STC2 mRNA CTD PMID:21172416 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Tfrc transferrin receptor increases expression EXP Diquat results in increased expression of TFRC mRNA CTD PMID:21698372 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of TNF protein] CTD PMID:29484840 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diquat results in increased expression of and affects the localization of TP53 protein; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; SN50 peptide inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein] CTD PMID:29484840 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO Diquat results in increased expression of TRIM16 mRNA CTD PMID:21172416 NCBI chr10:49,231,660...49,254,653
Ensembl chr10:49,231,730...49,254,621
JBrowse link
G Txn2 thioredoxin 2 increases expression
decreases response to substance
multiple interactions
ISO Diquat results in increased expression of TXN2 mRNA
TXN2 protein results in decreased susceptibility to Diquat
TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP3 protein]; TXN2 protein affects the reaction [Diquat results in increased cleavage of and results in increased activity of CASP9 protein]
CTD PMID:16962985, PMID:18164269 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Diquat results in increased expression of TXNRD1 mRNA CTD PMID:20826540, PMID:21172416 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Diquat results in increased expression of UPP1 mRNA CTD PMID:21172416 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO Diquat results in increased expression of ZFAND2A mRNA CTD PMID:21172416 NCBI chr12:17,252,093...17,263,477
Ensembl chr12:17,252,093...17,263,477
JBrowse link
tribufos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO butyl phosphorotrithioate metabolite results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases activity
multiple interactions
ISO butyl phosphorotrithioate results in decreased activity of CNR1 protein
butyl phosphorotrithioate inhibits the reaction [CP 55244 binds to CNR1 protein]
CTD PMID:12243867 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO butyl phosphorotrithioate results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO butyl phosphorotrithioate results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO butyl phosphorotrithioate binds to and results in increased activity of NR1I3 protein; butyl phosphorotrithioate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein] CTD PMID:18832183 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          herbicide 11200
            defoliant 246
              (2,4,5-trichlorophenoxy)acetic acid 106
              2,4-D 54
              diquat 95
              tribufos 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.