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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytochalasin
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Accession:CHEBI:23528 term browser browse the term
Synonyms:related_synonym: cytochalasins
 xref: Wikipedia:Cytochalasin



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chaetoglobosin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]
CTD PMID:18040759 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP chaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein] CTD PMID:18040759 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]
CTD PMID:18040759 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:33285210 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:33285210 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:33285210 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA] CTD PMID:33285210 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
chaetoglobosins results in increased phosphorylation of MAPK1 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP
ISO
chaetoglobosins results in increased phosphorylation of MAPK3 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA] CTD PMID:33285210 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:33285210 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:33285210 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation EXP chaetoglobosins results in decreased phosphorylation of RAF1 protein CTD PMID:18040759 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:33285210 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:33285210 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; chaetoglobosins results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 PMID:33285210 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
cytochalasin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in increased expression of BAX protein] CTD PMID:27640744 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cytochalasin B results in decreased expression of BCL2 protein] CTD PMID:27640744 NCBI chr13:22,689,783...22,853,920 JBrowse link
G C5 complement C5 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP3 protein CTD PMID:27640744 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Cytochalasin B results in increased cleavage of CASP9 protein CTD PMID:27640744 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of CAT protein] CTD PMID:20166893 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Cytochalasin B results in decreased expression of CCNB1 protein CTD PMID:27640744 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Cytochalasin B results in decreased expression of CDK1 protein CTD PMID:27640744 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Cytochalasin B results in increased expression of CDKN1A protein CTD PMID:27640744 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Cytochalasin B results in increased expression of CDKN1B protein CTD PMID:27640744 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin B inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein; pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein] CTD PMID:19686721 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Epo erythropoietin multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein; [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP Cytochalasin B results in increased expression of FIS1 protein CTD PMID:26732598 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Cytochalasin B results in increased expression of HSPA5 protein CTD PMID:26732598 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin B inhibits the reaction [[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form]; Cytochalasin B inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Cytochalasin B inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]] CTD PMID:9698594 PMID:17404311 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein] CTD PMID:18776917 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Lpl lipoprotein lipase decreases activity ISO Cytochalasin B results in decreased activity of LPL protein CTD PMID:9414485 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18776917 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18776917 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects folding
affects binding
multiple interactions
ISO Cytochalasin B affects the folding of SLC2A1 protein
Cytochalasin B binds to SLC2A1 protein
Cytochalasin B inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]
oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]
CTD PMID:8457197 PMID:19686715 PMID:22363641 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
affects binding
ISO
EXP
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]
Cytochalasin B binds to SLC2A2 protein
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Mercuric Chloride inhibits the reaction [Cytochalasin B binds to SLC2A2 protein]
CTD PMID:8457197 PMID:10825458 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose] CTD PMID:8457197 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of SOD2 protein] CTD PMID:20166893 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Cytochalasin B results in increased expression of TP53 protein CTD PMID:27640744 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
cytochalasin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]
Cytochalasin D results in increased expression of ACTA2 mRNA
CTD PMID:11035001 PMID:23517783 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein]
Cytochalasin D results in increased expression of CDH1 mRNA; Cytochalasin D results in increased expression of CDH1 protein
CTD PMID:25756282 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] CTD PMID:23517783 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA] CTD PMID:23517783 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Cytochalasin D inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein] CTD PMID:10645887 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein] CTD PMID:11145710 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein] CTD PMID:11145710 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA] CTD PMID:25858758 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO Cytochalasin D affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of IKBKB protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [titanium dioxide results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 PMID:18403674 PMID:18604214 PMID:24158569 PMID:24760326 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases chemical synthesis
increases stability
ISO Cytochalasin D results in decreased chemical synthesis of IL6 protein
Cytochalasin D results in increased stability of IL6 mRNA
CTD PMID:16499908 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases response to substance ISO IVNS1ABP gene mutant form results in increased susceptibility to Cytochalasin D CTD PMID:15485691 NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA] CTD PMID:17560598 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrtfa myocardin related transcription factor A multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen affects the localization of MRTFA protein] CTD PMID:23517783 NCBI chr 7:112,544,312...112,714,431
Ensembl chr 7:112,544,312...112,714,418
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 decreases localization ISO Cytochalasin D results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of NFKBIA protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G P2rx1 purinergic receptor P2X 1 decreases activity ISO Cytochalasin D results in decreased activity of P2RX1 protein CTD PMID:21757694 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO Cytochalasin D results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Cytochalasin D results in increased expression of PLAT CTD PMID:12371961 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein] CTD PMID:25756282 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rs1 retinoschisin 1 decreases secretion ISO Cytochalasin D results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:33,963,657...33,992,115
Ensembl chr  X:33,963,657...33,992,115
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Smad1 SMAD family member 1 affects localization ISO Cytochalasin D affects the localization of SMAD1 protein CTD PMID:25756282 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad2 SMAD family member 2 affects localization ISO Cytochalasin D affects the localization of SMAD2 protein CTD PMID:25756282 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 affects localization ISO Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snai1 snail family transcriptional repressor 1 affects localization ISO Cytochalasin D affects the localization of SNAI1 protein CTD PMID:25756282 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT3 protein CTD PMID:28086195 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tagln transgelin increases expression EXP Cytochalasin D results in increased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA]
Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:8409756 PMID:12799187 PMID:15034928 PMID:17560598 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein] CTD PMID:22961094 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization
multiple interactions
ISO Cytochalasin D affects the localization of UPF1 protein
Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]
CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
JBrowse link
G Upf2 UPF2, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr17:72,224,575...72,335,896
Ensembl chr17:72,225,316...72,335,855
JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr  X:116,335,308...116,353,332
Ensembl chr  X:116,335,308...116,353,236
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15034928 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    chemical entity 20038
      atom 20037
        nonmetal atom 19926
          nitrogen atom 18913
            nitrogen molecular entity 18913
              organonitrogen compound 18690
                organonitrogen heterocyclic compound 17734
                  benzopyrrole 9597
                    isoindoles 1133
                      cytochalasin 77
                        (1S,2R,3R,6S,7R,8S,11S,14S,15S,18R)-18-hydroxy-5,6,15-trimethyl-8-(2-methylpropyl)-19-oxa-9-azapentacyclo[13.3.1.02,14.03,11.07,11]nonadec-4-ene-10,12-dione 0
                        (3E,9E)-5,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione 0
                        (9E)-4,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,5,18-trione 0
                        (9E)-5,6-Dihydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                        (9E)-5-Hydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                        6-hydroxy-10,14,15-trimethyl-17-(2-methylpropyl)-2-oxa-18-azatricyclo[10.7.0.01,16]nonadeca-4,10,13-triene-3,19-dione 0
                        Cytochalasin A 0
                        LSM-6235 0
                        cytochalasan alkaloid + 16
                        cytochalasin B 27
                        cytochalasin D 43
                        phomacin A 0
                        phomacin B 0
                        phomacin C 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic molecule 19798
                              organic cyclic compound 19560
                                organic heterocyclic compound 18776
                                  organic heteropolycyclic compound 18245
                                    organic heterobicyclic compound 17128
                                      benzopyrrole 9597
                                        isoindoles 1133
                                          cytochalasin 77
                                            (1S,2R,3R,6S,7R,8S,11S,14S,15S,18R)-18-hydroxy-5,6,15-trimethyl-8-(2-methylpropyl)-19-oxa-9-azapentacyclo[13.3.1.02,14.03,11.07,11]nonadec-4-ene-10,12-dione 0
                                            (3E,9E)-5,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione 0
                                            (9E)-4,6-Dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,5,18-trione 0
                                            (9E)-5,6-Dihydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                                            (9E)-5-Hydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione 0
                                            6-hydroxy-10,14,15-trimethyl-17-(2-methylpropyl)-2-oxa-18-azatricyclo[10.7.0.01,16]nonadeca-4,10,13-triene-3,19-dione 0
                                            Cytochalasin A 0
                                            LSM-6235 0
                                            cytochalasan alkaloid + 16
                                            cytochalasin B 27
                                            cytochalasin D 43
                                            phomacin A 0
                                            phomacin B 0
                                            phomacin C 0
paths to the root