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G |
Gsta3 |
glutathione S-transferase alpha 3 |
affects binding |
ISO |
8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 binds to GSTA3 protein |
CTD |
PMID:8910329 |
|
NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
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G |
Ctsd |
cathepsin D |
multiple interactions |
EXP |
alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] |
CTD |
PMID:17623887 |
|
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] |
CTD |
PMID:29305303 |
|
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases secretion multiple interactions |
ISO |
alliin results in decreased secretion of FGF2 protein alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:16351512 |
|
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP ISO |
alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein] |
CTD |
PMID:16640830 PMID:29305303 |
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NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions |
EXP |
alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] |
CTD |
PMID:16640830 |
|
NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] |
CTD |
PMID:29305303 |
|
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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|
G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] |
CTD |
PMID:29305303 |
|
NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:16351512 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Vegfa |
vascular endothelial growth factor A |
decreases secretion |
ISO |
alliin results in decreased secretion of VEGFA protein |
CTD |
PMID:16351512 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein |
CTD |
PMID:28549670 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Dpep1 |
dipeptidase 1 |
decreases activity |
ISO |
Cilastatin results in decreased activity of DPEP1 protein |
CTD |
PMID:30664745 |
|
NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
multiple interactions |
EXP |
GSTA4 protein binds to and affects the metabolism of gamma-glutamyl-glutathione |
CTD |
PMID:2619714 |
|
NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
EXP |
GSTP1 protein binds to and affects the metabolism of gamma-glutamyl-glutathione |
CTD |
PMID:2619714 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions increases expression |
ISO |
Glutathione promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]; Quercetin promotes the reaction [Glutathione results in increased expression of ABCA1 mRNA] |
CTD |
PMID:25204422 |
|
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
affects export |
ISO |
ABCB4 protein affects the export of Glutathione |
CTD |
PMID:11302927 |
|
NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export increases uptake multiple interactions increases export affects transport |
ISO EXP |
ABCC1 protein affects the export of Glutathione ABCC1 protein results in increased uptake of Glutathione [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; [Glutathione binds to 10-nitro-oleic acid] promotes the reaction [ABCC1 protein results in increased export of 10-nitro-oleic acid metabolite]; [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione]; ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]; Genistein promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of arsenic trioxide]; Glutathione binds to and affects the folding of and affects the activity of ABCC1 protein; Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; Glutathione results in increased stability of and results in decreased degradation of and affects the localization of ABCC1 protein mutant form; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]; Quercetin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]] [verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione] ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione] ABCC1 protein affects the transport of Glutathione; ABCC1 protein affects the transport of Glutathione analog |
CTD |
PMID:11278867 PMID:11306701 PMID:12018890 PMID:12485947 PMID:12504668 PMID:15161912 PMID:15245331 PMID:15498506 PMID:15561710 PMID:15579473 PMID:15581632 PMID:15766272 PMID:16679408 PMID:17272743 PMID:20584751 PMID:21856323 PMID:21918036 PMID:23542460 PMID:29158255 |
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NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions affects abundance affects transport |
ISO EXP |
ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione]; Glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate] ABCC2 protein affects the abundance of Glutathione ABCC2 protein affects the transport of Glutathione ABCC2 protein affects the transport of Glutathione analog |
CTD |
PMID:16002050 PMID:16049127 PMID:16611851 PMID:20584751 PMID:25450747 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 PMID:21856323 |
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NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions affects transport |
ISO |
ABCC4 protein results in increased export of [2,6-dibromobenzoquinone binds to Glutathione]; ABCC4 protein results in increased export of [2,6-dichloro-(1,4)benzoquinone binds to Glutathione]; Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] ABCC4 protein affects the transport of Glutathione analog |
CTD |
PMID:15210835 PMID:20584751 PMID:28885828 |
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NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions affects transport |
ISO |
ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione] ABCC5 protein affects the transport of Glutathione analog |
CTD |
PMID:20584751 PMID:21856323 |
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NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
multiple interactions |
ISO |
Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 |
|
NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases export |
ISO |
2',5'-dihydroxychalcone promotes the reaction [ABCG2 protein results in increased export of Glutathione]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of Glutathione] |
CTD |
PMID:20332504 |
|
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ACOX1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ACSL4 mRNA |
CTD |
PMID:15345336 |
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NCBI chr X:113,596,247...113,660,024
Ensembl chr X:113,596,239...113,659,944
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G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:19428350 |
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NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
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G |
Agt |
angiotensinogen |
multiple interactions decreases abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione] AGT protein modified form results in increased chemical synthesis of [4-oxo-2-nonenal binds to Glutathione] AGT protein modified form results in decreased abundance of Glutathione; AGT protein results in decreased abundance of Glutathione |
CTD |
PMID:17272743 PMID:30703374 PMID:31144504 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased abundance of Glutathione] |
CTD |
PMID:12398935 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Nitroprusside results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Paraquat results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione] |
CTD |
PMID:15316071 |
|
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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G |
Akap1 |
A-kinase anchoring protein 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKAP1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276
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G |
Akr1b1 |
aldo-keto reductase family 1 member B |
increases glutathionylation increases reduction affects binding |
ISO |
Glutathione results in increased glutathionylation of AKR1B1 protein modified form Glutathione results in increased reduction of AKR1B1 protein modified form AKR1B1 protein binds to Glutathione |
CTD |
PMID:11306073 PMID:19061876 |
|
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
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G |
Akr1b8 |
aldo-keto reductase family 1, member B8 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of AKR1B8 protein] |
CTD |
PMID:15175009 |
|
NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
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G |
Akr1d1 |
aldo-keto reductase family 1, member D1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKR1D1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
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G |
Akr7a2 |
aldo-keto reductase family 7, member A2 |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of AKR7A2 mRNA AKR7A2 protein inhibits the reaction [Vitamin K 3 results in decreased abundance of Glutathione] |
CTD |
PMID:15345336 PMID:22001351 |
|
NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
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G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKR7A3 mRNA |
CTD |
PMID:15345336 PMID:20621112 |
|
NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17640567 PMID:24015256 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP |
Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein] |
CTD |
PMID:21620807 |
|
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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G |
Alb |
albumin |
multiple interactions |
ISO |
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein |
CTD |
PMID:23791970 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
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G |
Ap2m1 |
adaptor related protein complex 2 subunit mu 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AP2M1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
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G |
Aplp2 |
amyloid beta precursor like protein 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of APLP2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
[Glutathione co-treated with Quercetin] promotes the reaction [APOA1 protein results in increased export of Cholesterol] |
CTD |
PMID:25204422 |
|
NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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G |
Apoe |
apolipoprotein E |
decreases abundance multiple interactions |
ISO |
APOE gene mutant form results in decreased abundance of Glutathione notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:24933211 |
|
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
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G |
App |
amyloid beta precursor protein |
decreases abundance multiple interactions |
EXP ISO |
APP protein modified form results in decreased abundance of Glutathione vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] |
CTD |
PMID:25654502 PMID:29545167 |
|
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
As3mt |
arsenite methyltransferase |
multiple interactions affects folding |
EXP ISO |
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenous acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of dimethylarsine]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine] Glutathione affects the folding of AS3MT protein Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; Glutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite]; Glutathione results in increased reduction of and affects the folding of AS3MT protein |
CTD |
PMID:15606138 PMID:22868225 PMID:22955273 PMID:25349987 |
|
NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein] |
CTD |
PMID:24515801 PMID:30266318 |
|
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form] |
CTD |
PMID:27349771 |
|
NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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G |
Atg5 |
autophagy related 5 |
multiple interactions affects abundance |
ISO |
[ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; ATG5 protein affects the reaction [Acetaminophen affects the abundance of Glutathione] ATG5 protein affects the abundance of Glutathione |
CTD |
PMID:22491424 |
|
NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
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G |
Atg7 |
autophagy related 7 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] |
CTD |
PMID:29247770 |
|
NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ATP1B1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
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G |
Atp7b |
ATPase copper transporting beta |
decreases abundance multiple interactions |
ISO |
ATP7B gene mutant form results in decreased abundance of Glutathione Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Zinc Sulfate inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:24368744 |
|
NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Glutathione results in increased expression of BAX protein Glutathione inhibits the reaction [Acrolein results in increased expression of BAX protein] [[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein] |
CTD |
PMID:10897038 PMID:21621595 PMID:24036456 PMID:24376112 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases export |
ISO |
Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]] [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA; Glutathione inhibits the reaction [Acrolein results in decreased expression of BCL2 protein] BCL2 protein results in decreased export of Glutathione |
CTD |
PMID:15561710 PMID:17640567 PMID:22564015 PMID:24036456 PMID:24376112 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]] |
CTD |
PMID:17640567 |
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NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Bcl3 |
BCL3, transcription coactivator |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of BCL3 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
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G |
Bdh2 |
3-hydroxybutyrate dehydrogenase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of BDH2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] |
CTD |
PMID:17640567 |
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NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Thimerosal results in decreased expression of BIRC3 protein] |
CTD |
PMID:12140745 |
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NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
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G |
Bmi1 |
BMI1 proto-oncogene, polycomb ring finger |
increases abundance |
ISO |
BMI1 protein results in increased abundance of Glutathione |
CTD |
PMID:21445297 |
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NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
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G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] |
CTD |
PMID:19442826 |
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NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
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G |
Bst2 |
bone marrow stromal cell antigen 2 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of BST2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
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G |
C5 |
complement C5 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of C5 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 3:14,049,993...14,113,931 NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP3 protein] Glutathione results in increased activity of CASP3 protein Glutathione inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [JP8 aviation fuel results in increased activity of CASP3 protein] Glutathione inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein] |
CTD |
PMID:10385654 PMID:11969376 PMID:12140745 PMID:14660655 PMID:15683462 PMID:17640567 PMID:21300145 PMID:21621595 PMID:24036456 PMID:24376112 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp6 |
caspase 6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CASP6 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967 Ensembl chr 2:235,341,365...235,353,967
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein] |
CTD |
PMID:24515801 |
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NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein] Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein] |
CTD |
PMID:24376112 PMID:24515801 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP9 protein] |
CTD |
PMID:12140745 PMID:18594523 |
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NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
multiple interactions decreases response to substance |
ISO EXP |
[INS1 protein co-treated with Glutathione] affects the activity of CAT protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT protein inhibits the reaction [casiopeina II results in decreased abundance of Glutathione] CAT protein results in decreased susceptibility to Glutathione Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of CAT protein]; Glutathione inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Glutathione inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein] |
CTD |
PMID:19419996 PMID:20580664 PMID:21354300 PMID:21620807 PMID:25362599 PMID:26187465 PMID:27718046 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cav2 |
caveolin 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CAV2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 4:44,573,264...44,580,640
Ensembl chr 4:44,573,264...44,580,638
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G |
Cbr3 |
carbonyl reductase 3 |
multiple interactions |
ISO |
[GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein |
CTD |
PMID:25446851 |
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NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
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G |
Cbs |
cystathionine beta synthase |
decreases abundance |
ISO |
CBS gene mutant form results in decreased abundance of Glutathione |
CTD |
PMID:15016621 |
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NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein] |
CTD |
PMID:10919993 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
decreases expression |
ISO |
Glutathione results in decreased expression of CCL20 mRNA |
CTD |
PMID:22385246 |
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NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Particulate Matter analog results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Vehicle Emissions analog results in increased secretion of CCL5 protein] |
CTD |
PMID:10919993 |
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NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]] |
CTD |
PMID:17640567 |
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NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Cd14 |
CD14 molecule |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CD14 mRNA |
CTD |
PMID:15345336 |
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NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
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G |
Cd36 |
CD36 molecule |
multiple interactions decreases expression |
ISO |
[GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein Glutathione results in decreased expression of CD36 protein |
CTD |
PMID:26187465 |
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NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein] |
CTD |
PMID:27634759 |
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NCBI chr X:159,703,703...159,714,886
Ensembl chr X:159,703,578...159,716,562
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G |
Cd86 |
CD86 molecule |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein] |
CTD |
PMID:20457211 |
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NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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G |
Cdc25b |
cell division cycle 25B |
multiple interactions |
ISO |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate |
CTD |
PMID:20025242 |
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NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
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G |
Cdc25c |
cell division cycle 25C |
multiple interactions |
ISO |
[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate |
CTD |
PMID:20025242 |
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NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CDK4 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein] |
CTD |
PMID:22927544 |
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NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cdo1 |
cysteine dioxygenase type 1 |
increases abundance |
EXP |
CDO1 protein results in increased abundance of Glutathione |
CTD |
PMID:23665415 |
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NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA] |
CTD |
PMID:21220312 |
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NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions affects export decreases activity |
ISO |
[Bicarbonates co-treated with Glutathione co-treated with Ascorbic Acid] results in increased activity of CFTR protein; [Glutathione co-treated with Diamide] results in decreased activity of CFTR protein; Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]; Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CFTR protein affects the export of Glutathione Glutathione analog results in decreased activity of CFTR protein |
CTD |
PMID:15561710 PMID:15657297 PMID:15857825 PMID:32374624 |
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NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] |
CTD |
PMID:17067557 |
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NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
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G |
Cldn4 |
claudin 4 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
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NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
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G |
Clu |
clusterin |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CLU mRNA |
CTD |
PMID:15345336 |
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NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
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G |
Cntf |
ciliary neurotrophic factor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]] |
CTD |
PMID:16896058 |
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NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CPT1A mRNA |
CTD |
PMID:15345336 |
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NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
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G |
Creg1 |
cellular repressor of E1A-stimulated genes 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CREG1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:15175009 |
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NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
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G |
Ctps1 |
CTP synthase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CTPS mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of CXCL1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein] |
CTD |
PMID:26149495 |
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NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein |
CTD |
PMID:21621595 |
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NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac |
CTD |
PMID:18078826 PMID:21094198 PMID:24246759 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP1A2 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [myristicin results in decreased activity of CYP1A2 protein] |
CTD |
PMID:20825217 PMID:24246759 PMID:26091900 PMID:31102647 PMID:32198085 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione]; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione] |
CTD |
PMID:14679015 PMID:24246759 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[CYP2A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine |
CTD |
PMID:20825217 |
|
NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] |
CTD |
PMID:24246759 PMID:32198085 |
|
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
ISO |
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2C9 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione affects the reaction [CYP2C9 protein results in increased hydroxylation of bromfenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] |
CTD |
PMID:24246759 PMID:31815452 PMID:32198085 |
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NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
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G |
Cyp2c24 |
cytochrome P450, family 2, subfamily c, polypeptide 24 |
multiple interactions |
ISO |
[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions |
ISO |
[CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2C19 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] |
CTD |
PMID:24246759 PMID:31102647 PMID:32198085 |
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NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
multiple interactions |
ISO |
[CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 1:147,236,480...147,307,988
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein] |
CTD |
PMID:20825217 PMID:24246759 PMID:31102647 PMID:32198085 |
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NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO EXP |
[CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione; [CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene] Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein] 1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite] |
CTD |
PMID:8211999 PMID:10573527 PMID:16872732 PMID:21842885 PMID:24246759 PMID:28803762 PMID:32198085 |
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NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
multiple interactions |
ISO |
[CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine |
CTD |
PMID:20825217 |
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NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
[CYP3A23-3A1 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine |
CTD |
PMID:20825217 |
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NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
affects binding multiple interactions |
ISO |
Glutathione binds to CYP3A4 protein [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione; [CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP3A4 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; CYP3A4 protein promotes the reaction [Acetaminophen results in decreased abundance of Glutathione]; Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline]; Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] |
CTD |
PMID:15523003 PMID:18206979 PMID:20825217 PMID:24246759 PMID:25451576 PMID:27485346 PMID:31102647 PMID:32198085 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione] |
CTD |
PMID:24246759 PMID:26302866 |
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NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein] Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] |
CTD |
PMID:17171638 PMID:20493918 PMID:24515801 |
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NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Decr1 |
2,4-dienoyl-CoA reductase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DECR1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
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G |
Decr2 |
2,4-dienoyl-CoA reductase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DECR2 mRNA |
CTD |
PMID:15345336 |
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NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
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G |
Defb4 |
defensin beta 4 |
decreases expression |
ISO |
Glutathione results in decreased expression of DEFB4A mRNA |
CTD |
PMID:22385246 |
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NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
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G |
Dek |
DEK proto-oncogene |
decreases chemical synthesis |
ISO |
DEK protein results in decreased chemical synthesis of Glutathione |
CTD |
PMID:28558019 |
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NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] |
CTD |
PMID:28803762 |
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NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
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G |
Dio1 |
iodothyronine deiodinase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DIO1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] |
CTD |
PMID:27624276 PMID:28153600 |
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NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 protein] |
CTD |
PMID:18573614 |
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NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
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G |
Egf |
epidermal growth factor |
affects abundance |
EXP |
EGF protein affects the abundance of Glutathione |
CTD |
PMID:10544272 |
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NCBI chr 2:68,820,616...68,895,537
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein] [Acetaminophen results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein; [phorone results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein |
CTD |
PMID:14660655 PMID:28123000 |
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NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of EIF2AK2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] |
CTD |
PMID:24515801 PMID:30266318 |
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NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:30266318 |
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NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] |
CTD |
PMID:23958427 |
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NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of EPHX1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
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G |
Epo |
erythropoietin |
multiple interactions |
EXP ISO |
EPO protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione] EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione] |
CTD |
PMID:16405037 PMID:22013135 |
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NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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G |
Extl1 |
exostosin-like glycosyltransferase 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of EXTL1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 5:152,573,755...152,588,956
Ensembl chr 5:152,573,758...152,589,719
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G |
F3 |
coagulation factor III, tissue factor |
increases activity |
ISO |
Glutathione results in increased activity of F3 protein |
CTD |
PMID:17726162 |
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NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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G |
Fahd1 |
fumarylacetoacetate hydrolase domain containing 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of FAHD1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr10:14,214,518...14,215,957
Ensembl chr10:14,214,519...14,215,957
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G |
Fas |
Fas cell surface death receptor |
multiple interactions affects chemical synthesis |
ISO |
[FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; FAS protein affects the reaction [Acetaminophen affects the chemical synthesis of Glutathione]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein] FAS protein affects the chemical synthesis of Glutathione |
CTD |
PMID:10385654 PMID:23628456 |
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NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Faslg |
Fas ligand |
decreases abundance multiple interactions |
ISO |
FASL protein results in decreased abundance of Glutathione Glutathione inhibits the reaction [Acrolein results in increased expression of FASL protein] verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione] |
CTD |
PMID:17724027 PMID:24376112 |
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NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Fasn |
fatty acid synthase |
decreases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in decreased expression of FASN mRNA Glutathione inhibits the reaction [Alcohols results in increased expression of FASN protein] |
CTD |
PMID:20621112 PMID:28803762 |
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NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Fgf1 |
fibroblast growth factor 1 |
multiple interactions |
EXP |
2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]; FGF1 protein results in increased abundance of and results in increased secretion of Glutathione |
CTD |
PMID:16524372 |
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NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] |
CTD |
PMID:19524604 |
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NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
Fndc5 |
fibronectin type III domain containing 5 |
multiple interactions increases abundance |
ISO EXP |
FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione] FNDC5 protein results in increased abundance of Glutathione |
CTD |
PMID:30703374 PMID:32165127 |
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NCBI chr 5:147,323,240...147,330,266
Ensembl chr 5:147,323,240...147,330,266
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione affects the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] |
CTD |
PMID:15105052 PMID:15520183 PMID:18449455 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA] |
CTD |
PMID:15520183 |
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NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Glutathione inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] |
CTD |
PMID:20580664 |
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NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA] |
CTD |
PMID:16631525 |
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NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of FTL1 protein] |
CTD |
PMID:15175009 |
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NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] |
CTD |
PMID:14572611 |
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NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO EXP |
Glutathione inhibits the reaction [Quartz results in decreased activity of G6PDX protein] Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein] Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA] |
CTD |
PMID:14613721 PMID:15225644 PMID:18370412 |
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NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO EXP |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]; [GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Glutathione results in increased metabolism of and results in increased activity of GAPDH protein modified form; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] Glutathione inhibits the reaction [arsenite results in decreased expression of GAPDH protein] |
CTD |
PMID:15175009 PMID:15788719 PMID:21827172 |
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NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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G |
Gch1 |
GTP cyclohydrolase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GCH1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases abundance increases expression affects chemical synthesis |
ISO EXP |
[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride; [Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]] GCLC mRNA results in increased abundance of Glutathione; GCLC protein results in increased abundance of Glutathione [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein; [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione]; GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]; GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione] Glutathione deficiency results in increased expression of GCLC mRNA GCLC polymorphism affects the chemical synthesis of Glutathione [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:7955076 PMID:10544272 PMID:11673643 PMID:12504668 PMID:14978233 PMID:15282320 PMID:15345336 PMID:15707499 PMID:16599007 PMID:17724089 PMID:18556457 PMID:19914271 PMID:20159942 PMID:20621112 PMID:21728338 PMID:21833590 PMID:22762311 PMID:23628456 PMID:26187465 |
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NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases abundance increases chemical synthesis affects response to substance affects metabolic processing decreases abundance increases expression |
ISO EXP |
[Chenodeoxycholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]; GCLM gene SNP results in decreased chemical synthesis of and results in decreased abundance of Glutathione GCLM gene SNP results in increased abundance of Glutathione GCLM protein results in increased chemical synthesis of Glutathione GCLM protein affects the susceptibility to Glutathione GCLM protein affects the metabolism of Glutathione GCLM gene mutant form results in decreased abundance of Glutathione; GCLM protein mutant form results in decreased abundance of Glutathione Glutathione deficiency results in increased expression of GCLM mRNA [GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene; [GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:12975258 PMID:15345336 PMID:17584759 PMID:17724089 PMID:20159942 PMID:20417186 PMID:20621112 PMID:22253057 PMID:23135907 PMID:23704229 PMID:24107266 PMID:25446851 PMID:32715377 |
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NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
[acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; [hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione] |
CTD |
PMID:15629191 PMID:19419996 |
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NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
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G |
Glrx |
glutaredoxin |
multiple interactions |
ISO EXP |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] [GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] |
CTD |
PMID:12680778 PMID:20025242 PMID:24451382 |
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NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
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G |
Glrx3 |
glutaredoxin 3 |
multiple interactions |
ISO |
[frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione |
CTD |
PMID:30661989 |
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NCBI chr 1:209,768,696...209,799,912
Ensembl chr 1:209,768,696...209,799,903
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G |
Gne |
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of GNE mRNA |
CTD |
PMID:20621112 |
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NCBI chr 5:59,511,738...59,553,421
Ensembl chr 5:59,512,872...59,553,416
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G |
Gnl3 |
G protein nucleolar 3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GNL3 mRNA |
CTD |
PMID:20621112 |
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NCBI chr16:7,097,580...7,103,518
Ensembl chr16:7,097,507...7,103,604
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
[GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] |
CTD |
PMID:16636302 |
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NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases abundance |
ISO |
GSK3B protein mutant form results in increased abundance of Glutathione |
CTD |
PMID:25246272 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity affects activity increases expression |
ISO EXP |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate Glutathione results in decreased activity of GSR protein Glutathione inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein] Glutathione deficiency affects the activity of GSR protein Glutathione deficiency results in increased expression of GSR mRNA 1'-acetoxychavicol acetate analog inhibits the reaction [GSR protein results in increased reduction of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; Glutathione inhibits the reaction [Alcohols results in decreased expression of GSR protein] |
CTD |
PMID:15345336 PMID:15707499 PMID:17272743 PMID:20025242 PMID:20230805 PMID:23172834 PMID:24038001 PMID:28803762 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
[Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:18487201 |
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NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions affects binding affects metabolic processing |
ISO EXP |
GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione] Glutathione binds to GSTA1 protein [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]; GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione] GSTA1 protein affects the metabolism of Glutathione |
CTD |
PMID:3783048 PMID:7712478 PMID:8886613 PMID:9084911 PMID:9877184 PMID:10437668 PMID:10496977 PMID:10751412 PMID:11115505 PMID:11368548 PMID:11849043 PMID:12147362 PMID:12516103 PMID:14690442 PMID:16890185 |
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NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions affects metabolic processing |
ISO EXP |
[GSTA2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine GSTA2 protein affects the metabolism of Glutathione [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; GSTA2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione] |
CTD |
PMID:8973562 PMID:9084911 PMID:9877184 PMID:28478157 |
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NCBI chr 8:85,640,081...85,645,621
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
affects binding affects metabolic processing increases expression multiple interactions |
ISO EXP |
Glutathione binds to GSTA3 protein GSTA3 protein affects the metabolism of Glutathione Glutathione deficiency results in increased expression of GSTA3 mRNA Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]] |
CTD |
PMID:3783048 PMID:6095330 PMID:8910329 PMID:15345336 |
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NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTA4 protein affects the metabolism of Glutathione [GSTA4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine |
CTD |
PMID:14727915 PMID:28478157 |
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NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GSTA5 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
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G |
Gstk1 |
glutathione S-transferase kappa 1 |
multiple interactions |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA |
CTD |
PMID:22564015 |
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NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
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G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions affects metabolic processing decreases abundance increases expression affects binding |
ISO EXP |
4-O-decyl-gabosine D inhibits the reaction [Glutathione binds to GSTM1 protein]; [GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; GSTM1 protein affects the metabolism of [1,2,5,6-dibenzanthracene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione]; GSTM1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Benzo(a)pyrene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [chrysene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione] GSTM5 protein affects the metabolism of Glutathione GSTM1 gene mutant form results in decreased abundance of Glutathione Glutathione analog binds to and results in decreased activity of GSTM1 protein; GSTM1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]; GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione] GSTM1 protein affects the metabolism of Glutathione Glutathione deficiency results in increased expression of GSTM1 mRNA |
CTD |
PMID:1883342 PMID:2604743 PMID:2904809 PMID:6095330 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9084911 PMID:9403173 PMID:9545290 PMID:11368548 PMID:11849043 PMID:14979731 PMID:15345336 PMID:21925487 PMID:22085405 PMID:25420021 |
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NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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G |
Gstm2 |
glutathione S-transferase mu 2 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTM2 protein affects the metabolism of Glutathione [GSTM2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]; GSTM2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione] |
CTD |
PMID:2604743 PMID:8924604 PMID:8973562 PMID:9794801 PMID:10858281 PMID:28478157 |
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NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
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G |
Gstm3 |
glutathione S-transferase mu 3 |
affects metabolic processing |
ISO |
GSTM3 protein affects the metabolism of Glutathione |
CTD |
PMID:9545290 |
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NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
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G |
Gstm3l |
glutathione S-transferase mu 3-like |
affects metabolic processing |
EXP |
GSTM5 protein affects the metabolism of Glutathione |
CTD |
PMID:9545290 |
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NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501
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G |
Gstm4 |
glutathione S-transferase mu 4 |
multiple interactions |
ISO |
[GSTM4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTM4 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione] |
CTD |
PMID:8203914 PMID:28478157 |
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NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
affects metabolic processing |
ISO |
GSTM3 protein affects the metabolism of Glutathione |
CTD |
PMID:9545290 |
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NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity multiple interactions increases expression affects metabolic processing |
ISO EXP |
Glutathione analog results in decreased activity of GSTP1 protein GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione] Glutathione deficiency results in increased expression of GSTP1 mRNA GSTP1 protein affects the metabolism of Glutathione Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]; GSTP1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione] [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2A6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]; GSTP1 protein affects the metabolism of [4-oxo-2-nonenal co-treated with Glutathione]; GSTP1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)phenanthrene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(g)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTP1 protein promotes the reaction [Glutathione binds to Atrazine]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] |
CTD |
PMID:7712478 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9403173 PMID:9877184 PMID:10334868 PMID:11196146 PMID:11368548 PMID:11849043 PMID:12470677 PMID:13679171 PMID:15115887 PMID:15528046 PMID:18607078 PMID:20570720 PMID:20621112 PMID:24246759 PMID:28478157 |
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NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Gstt1 |
glutathione S-transferase theta 1 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTT1 protein affects the metabolism of Glutathione GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione] GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione] |
CTD |
PMID:14727918 PMID:14998683 PMID:15533900 |
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NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
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G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects metabolic processing affects binding multiple interactions |
ISO |
GSTZ1 protein affects the metabolism of Glutathione Glutathione binds to GSTZ1 protein GSTZ1 protein binds to and affects the metabolism of Glutathione |
CTD |
PMID:1846734 PMID:9396740 PMID:11327815 PMID:12852784 PMID:15173170 |
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NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AX protein] |
CTD |
PMID:21722719 |
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NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HADHA mRNA |
CTD |
PMID:15345336 |
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NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
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G |
Has2 |
hyaluronan synthase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA] |
CTD |
PMID:21220312 |
|
NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
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G |
Hfe |
homeostatic iron regulator |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HFE mRNA |
CTD |
PMID:15345336 |
|
NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
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G |
Hgf |
hepatocyte growth factor |
increases abundance multiple interactions |
EXP |
HGF protein results in increased abundance of Glutathione [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:10544272 |
|
NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein] |
CTD |
PMID:11641398 PMID:16678800 PMID:17658243 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HMGCR mRNA |
CTD |
PMID:15345336 |
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NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression affects expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]; [Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]] [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [resveratrol results in increased abundance of Glutathione]; Glutathione inhibits the reaction [arsenite results in increased expression of HMOX1 protein] Glutathione deficiency results in increased expression of HMOX1 mRNA; Glutathione results in increased expression of HMOX1 mRNA Glutathione affects the expression of HMOX1 mRNA |
CTD |
PMID:8743975 PMID:12420312 PMID:15175009 PMID:15602829 PMID:16631525 PMID:18078826 PMID:18332044 PMID:20020861 PMID:20621112 PMID:20888885 PMID:20934533 PMID:20961405 PMID:21971136 PMID:23649983 PMID:23691207 PMID:26945724 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HNF4A mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene; Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene] |
CTD |
PMID:9345283 |
|
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD17B1 protein] |
CTD |
PMID:20580664 |
|
NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD3B1 protein] |
CTD |
PMID:20580664 |
|
|
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of HSPA1B protein] |
CTD |
PMID:15175009 |
|
NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] |
CTD |
PMID:20493918 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of HSPB1 protein] |
CTD |
PMID:15175009 |
|
NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
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G |
Iapp |
islet amyloid polypeptide |
multiple interactions |
ISO |
IAPP protein inhibits the reaction [[Copper co-treated with Glutathione] results in increased abundance of Hydrogen Peroxide] |
CTD |
PMID:23793354 |
|
NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:20351055 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in increased abundance of Glutathione Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Glutathione] |
CTD |
PMID:27469509 |
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NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein] [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]] |
CTD |
PMID:12847270 PMID:16896058 PMID:17079650 PMID:18214930 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions increases expression |
ISO |
deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGF1 mRNA] |
CTD |
PMID:19805407 |
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NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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G |
Igfals |
insulin-like growth factor binding protein, acid labile subunit |
multiple interactions increases expression |
ISO |
deoxynivalenol inhibits the reaction [Glutathione results in increased expression of IGFALS mRNA] |
CTD |
PMID:19805407 |
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NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
multiple interactions increases expression |
ISO |
deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGFBP3 mRNA] |
CTD |
PMID:19805407 |
|
NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions affects abundance |
ISO |
GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]] IKBKB protein affects the abundance of Glutathione |
CTD |
PMID:17067557 PMID:20159942 |
|
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein |
CTD |
PMID:18214930 |
|
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein; Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein] |
CTD |
PMID:17079650 PMID:18214930 |
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NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
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G |
Il1b |
interleukin 1 beta |
increases abundance decreases expression multiple interactions |
ISO |
IL1B protein results in increased abundance of Glutathione Glutathione results in decreased expression of IL1B mRNA Glutathione deficiency promotes the reaction [Phenol results in increased secretion of IL1B protein]; Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of IL1B protein] |
CTD |
PMID:10802230 PMID:17922553 PMID:22385246 PMID:26149495 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il33 |
interleukin 33 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of IL33 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased abundance of Glutathione [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein] |
CTD |
PMID:18214930 PMID:22107450 PMID:27634759 |
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NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Glutathione analog promotes the reaction [Ozone results in increased expression of IL6 protein]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] |
CTD |
PMID:15379216 PMID:17079650 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
INS protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] |
CTD |
PMID:26739624 |
|
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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G |
Isg20 |
interferon stimulated exonuclease gene 20 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ISG20 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] |
CTD |
PMID:16357311 |
|
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein] |
CTD |
PMID:12847270 |
|
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
ISO |
Glutathione affects the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein] Glutathione deficiency results in increased phosphorylation of JUN protein |
CTD |
PMID:12774022 PMID:15105052 PMID:15520183 PMID:18449455 PMID:30266318 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA] |
CTD |
PMID:15520183 |
|
NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions increases abundance |
ISO EXP |
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; [Plant Extracts results in decreased expression of KEAP1 protein] which results in increased chemical synthesis of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione] KEAP1 gene mutant form results in increased abundance of Glutathione Glutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein] [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased glutathionylation of KEAP1 protein]; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione] |
CTD |
PMID:19608619 PMID:20026152 PMID:20800667 PMID:21972102 PMID:22762311 PMID:25807370 PMID:26827822 |
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NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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G |
Klf4 |
Kruppel like factor 4 |
increases abundance multiple interactions |
ISO |
KLF4 results in increased abundance of Glutathione [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione |
CTD |
PMID:21833590 |
|
NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
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G |
Klkb1 |
kallikrein B1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of KLKB1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
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G |
Krt18 |
keratin 18 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of KRT18 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
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G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] |
CTD |
PMID:14572611 |
|
NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
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G |
Lepr |
leptin receptor |
multiple interactions |
EXP |
LEPR gene mutant form results in increased oxidation of and results in decreased abundance of Glutathione |
CTD |
PMID:29743445 |
|
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [sodium arsenite results in decreased expression of LHB protein] Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] |
CTD |
PMID:20580664 PMID:21220312 |
|
NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
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G |
Lrp1 |
LDL receptor related protein 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of LRP1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] |
CTD |
PMID:14572611 |
|
NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
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G |
Maob |
monoamine oxidase B |
multiple interactions |
ISO |
Glutathione inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole] |
CTD |
PMID:26686552 |
|
NCBI chr X:6,430,694...6,533,520
Ensembl chr X:6,430,594...6,533,534
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of MAP1LC3B mRNA Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:15345336 PMID:29247770 |
|
NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
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G |
Map2 |
microtubule-associated protein 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA] |
CTD |
PMID:28153600 |
|
NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein] Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:10658192 PMID:12083801 PMID:15252869 PMID:21971136 PMID:22767315 PMID:23370007 PMID:24015256 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK3 protein] Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:12083801 PMID:15252869 PMID:21971136 PMID:22767315 PMID:24015256 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO EXP |
Glutathione deficiency promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein] Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK8 protein] Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:16112521 PMID:17481858 PMID:20423716 PMID:22767315 |
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NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO EXP |
Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein] Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:20423716 PMID:22767315 |
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NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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G |
Me1 |
malic enzyme 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ME1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
multiple interactions |
ISO |
MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased oxidation of Glutathione] |
CTD |
PMID:27394961 |
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NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
multiple interactions |
ISO |
Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin] |
CTD |
PMID:16039682 |
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NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
multiple interactions |
EXP |
[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Glutathione binds to and results in increased activity of MGST1 protein; Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein]; MGST1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; MGST1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein] |
CTD |
PMID:9890956 PMID:12470677 PMID:16386761 |
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NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases secretion |
ISO |
Glutathione results in decreased secretion of MMP2 protein |
CTD |
PMID:15147517 |
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NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
affects binding multiple interactions decreases secretion |
ISO |
Glutathione binds to MMP9 protein Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of MMP9 protein] Glutathione results in decreased secretion of MMP9 protein Glutathione inhibits the reaction [4-aminophenylmercuriacetate results in increased activity of MMP9 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein] |
CTD |
PMID:15147517 PMID:17015178 PMID:17640567 PMID:21722719 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione; [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in decreased abundance of Glutathione; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Glutathione promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Glutathione promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile] |
CTD |
PMID:19462961 PMID:25614581 PMID:28754375 PMID:31288001 |
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NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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G |
Mst1r |
macrophage stimulating 1 receptor |
multiple interactions |
ISO |
MST1R protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] |
CTD |
PMID:22575169 |
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NCBI chr 8:116,686,601...116,700,132
Ensembl chr 8:116,686,601...116,700,132
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G |
Mt1 |
metallothionein 1 |
multiple interactions increases expression |
ISO EXP |
[MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin] Glutathione deficiency results in increased expression of MT1A mRNA |
CTD |
PMID:15345336 PMID:20600803 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
[MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin] |
CTD |
PMID:20600803 |
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NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]] |
CTD |
PMID:9507026 |
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NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] |
CTD |
PMID:26989453 |
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NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
affects abundance multiple interactions |
ISO EXP |
MYC protein affects the abundance of Glutathione Glutathione inhibits the reaction [arsenite results in increased expression of MYC mRNA] |
CTD |
PMID:9848127 PMID:12226097 |
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NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions increases abundance decreases abundance affects abundance |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein; [Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein; [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of NFE2L2 protein]; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione]; NFE2L2 protein affects the reaction [Silver results in increased abundance of Glutathione] NFE2L2 protein results in increased abundance of Glutathione NFE2L2 gene mutant form results in decreased abundance of Glutathione NFE2L2 protein affects the abundance of Glutathione NFE2L2 protein inhibits the reaction [triptolide results in decreased abundance of Glutathione] [ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [Dinitrochlorobenzene results in decreased abundance of Glutathione]; sulforafan affects the reaction [NFE2L2 affects the abundance of Glutathione] NFE2L2 affects the abundance of Glutathione; NFE2L2 protein affects the abundance of Glutathione |
CTD |
PMID:11287661 PMID:16524372 PMID:16631525 PMID:19303893 PMID:19608619 PMID:20124447 PMID:20800667 PMID:21728338 PMID:21971136 PMID:22491424 PMID:22546375 PMID:22762311 PMID:22820427 PMID:23649983 PMID:23764462 PMID:24211276 PMID:27633142 PMID:28219650 PMID:29618784 PMID:31299238 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] |
CTD |
PMID:16219905 PMID:17640567 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] |
CTD |
PMID:17067557 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Ngf |
nerve growth factor |
multiple interactions affects reduction affects oxidation affects activity |
EXP ISO |
N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] NGF protein affects the reduction of Glutathione NGF protein affects the oxidation of Glutathione |
CTD |
PMID:12381813 PMID:23472850 |
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NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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G |
Nlgn3 |
neuroligin 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] |
CTD |
PMID:27624276 |
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NCBI chr X:71,199,390...71,227,460
Ensembl chr X:71,199,491...71,222,732
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G |
Nnmt |
nicotinamide N-methyltransferase |
increases abundance |
ISO |
NNMT protein results in increased abundance of Glutathione |
CTD |
PMID:31909875 |
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NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]] Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [orazipone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] |
CTD |
PMID:17640567 PMID:18039960 PMID:21722719 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions decreases expression |
EXP ISO |
Glutathione deficiency results in increased expression of NQO1 mRNA Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NQO1 protein] Glutathione results in decreased expression of NQO1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA] |
CTD |
PMID:15345336 PMID:20800667 PMID:21034357 PMID:21971136 |
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NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of NR0B2 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione] |
CTD |
PMID:26160115 |
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NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of PARP protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] |
CTD |
PMID:24515801 PMID:26035713 |
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NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA] |
CTD |
PMID:28943456 |
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NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
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G |
Nrxn1 |
neurexin 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] |
CTD |
PMID:27624276 |
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NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
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G |
Oaf |
out at first homolog |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of OAF mRNA |
CTD |
PMID:20621112 |
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NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
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G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Glutathione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] |
CTD |
PMID:3098411 |
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NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
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G |
Ogdh |
oxoglutarate dehydrogenase |
multiple interactions |
EXP |
[GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]; Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein] |
CTD |
PMID:12680778 |
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NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
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G |
Ogg1 |
8-oxoguanine DNA glycosylase |
multiple interactions |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA |
CTD |
PMID:22564015 |
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NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
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G |
Panx1 |
Pannexin 1 |
decreases oxidation |
ISO |
PANX1 gene mutant form results in decreased oxidation of Glutathione |
CTD |
PMID:29246445 |
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NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
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G |
Park7 |
Parkinsonism associated deglycase |
increases abundance |
ISO |
PARK7 protein results in increased abundance of Glutathione |
CTD |
PMID:18331584 |
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NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Glutathione deficiency promotes the reaction [antimony trioxide results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [N-methylisoindigotin results in increased cleavage of PARP1 protein] |
CTD |
PMID:14660655 PMID:16112521 PMID:24036456 PMID:24515801 PMID:26887594 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of PCSK9 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
increases abundance |
ISO |
PDGFRB protein results in increased abundance of Glutathione |
CTD |
PMID:29857117 |
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NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein] |
CTD |
PMID:17171638 |
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NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA] |
CTD |
PMID:21220312 |
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NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Plin2 |
perilipin 2 |
multiple interactions |
ISO |
SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form] |
CTD |
PMID:27349771 |
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NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
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G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO |
PON1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] |
CTD |
PMID:20079818 |
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NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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G |
Pon3 |
paraoxonase 3 |
multiple interactions |
ISO |
PON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] |
CTD |
PMID:20079818 |
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NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
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G |
Ppan |
peter pan homolog |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PPAN mRNA |
CTD |
PMID:20621112 |
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NCBI chr 8:21,905,865...21,909,845
Ensembl chr 8:21,905,865...21,909,842
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression multiple interactions |
ISO |
Glutathione results in increased expression of PPARA mRNA Glutathione inhibits the reaction [Alcohols results in decreased expression of PPARA protein]; Quercetin promotes the reaction [Glutathione results in increased expression of PPARA mRNA] |
CTD |
PMID:25204422 PMID:28803762 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Glutathione analog results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
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NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Ppat |
phosphoribosyl pyrophosphate amidotransferase |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PPAT mRNA |
CTD |
PMID:20621112 |
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NCBI chr14:33,580,541...33,614,919
Ensembl chr14:33,580,541...33,614,919
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G |
Ppp1r3c |
protein phosphatase 1, regulatory subunit 3C |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PPP1R3C mRNA |
CTD |
PMID:20621112 |
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NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
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G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions |
ISO |
[frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione |
CTD |
PMID:30661989 |
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NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
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G |
Prdx2 |
peroxiredoxin 2 |
multiple interactions |
ISO |
SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein] |
CTD |
PMID:27349771 |
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NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
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G |
Prdx6 |
peroxiredoxin 6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PRDX6 mRNA |
CTD |
PMID:15345336 |
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NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
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G |
Prim2 |
DNA primase subunit 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PRIM2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
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G |
Prkcd |
protein kinase C, delta |
multiple interactions affects abundance |
ISO |
Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of PRKCD protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein] PRKCD protein affects the abundance of Glutathione |
CTD |
PMID:15131007 PMID:15707588 PMID:17171638 |
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NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
affects abundance |
ISO |
PRKN protein affects the abundance of Glutathione |
CTD |
PMID:12915482 |
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NCBI chr 1:48,880,015...50,069,998
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G |
Prnp |
prion protein |
multiple interactions |
ISO |
PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione] |
CTD |
PMID:17483122 |
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NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
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G |
Procr |
protein C receptor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in decreased expression of PROCR protein] |
CTD |
PMID:17172434 |
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NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
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G |
Ptbp1 |
polypyrimidine tract binding protein 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PTBP1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 7:12,663,965...12,673,723
Ensembl chr 7:12,663,965...12,673,718
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein] Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGS2 protein]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA] |
CTD |
PMID:17640567 PMID:21220312 PMID:21722719 PMID:22767315 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Ptma |
prothymosin alpha |
increases abundance multiple interactions decreases abundance |
ISO |
PTMA protein alternative form results in increased abundance of Glutathione PTMA protein inhibits the reaction [Dexamethasone results in decreased abundance of Glutathione] PTMA protein alternative form results in decreased abundance of Glutathione |
CTD |
PMID:9147362 PMID:19442654 |
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NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
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G |
Ptpn2 |
protein tyrosine phosphatase, non-receptor type 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein] |
CTD |
PMID:31248982 |
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NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
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G |
Ptprf |
protein tyrosine phosphatase, receptor type, F |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of PTPRF mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
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G |
Ptprs |
protein tyrosine phosphatase, receptor type, S |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of PTPRS mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in decreased phosphorylation of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] |
CTD |
PMID:11139434 PMID:22927544 |
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NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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G |
Rbm27 |
RNA binding motif protein 27 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of RBM27 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr18:36,596,568...36,657,157
Ensembl chr18:36,596,585...36,656,314
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G |
Rdh16 |
retinol dehydrogenase 16 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RDH2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases glutathionylation affects abundance |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; [cinnamic aldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] results in increased glutathionylation of RELA protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]] Glutathione results in increased glutathionylation of RELA protein RELA protein affects the abundance of Glutathione Glutathione affects the reaction [Sodium Selenite results in increased expression of RELA mRNA]; Glutathione inhibits the reaction [Alcohols results in increased expression of RELA protein] |
CTD |
PMID:16219905 PMID:17640567 PMID:18449455 PMID:20116392 PMID:20159942 PMID:20351055 PMID:28803762 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Reln |
reelin |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of RELN mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
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G |
Retreg1 |
reticulophagy regulator 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RETREG1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 2:78,391,921...78,401,569
Ensembl chr 2:78,391,921...78,399,987
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G |
Rfk |
riboflavin kinase |
increases abundance |
ISO |
RFK protein results in increased abundance of Glutathione |
CTD |
PMID:21308351 |
|
NCBI chr 1:236,494,221...236,501,733
Ensembl chr 1:236,494,221...236,501,733
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G |
RGD1309808 |
similar to apolipoprotein L2; apolipoprotein L-II |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of RGD1309808 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 7:118,700,952...118,719,160
Ensembl chr 7:118,692,851...118,719,156
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G |
Rps6 |
ribosomal protein S6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RPS6 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RPS6KB1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
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G |
Rreb1 |
ras responsive element binding protein 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of RREB1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr17:27,539,137...27,718,878
Ensembl chr17:27,539,133...27,665,266
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G |
Rup2 |
urinary protein 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RUP2 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 8:41,657,662...41,661,223
Ensembl chr 8:41,657,566...41,661,238
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions affects abundance |
ISO |
GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione] |
CTD |
PMID:14978233 |
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NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
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G |
Samd4a |
sterile alpha motif domain containing 4A |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SAMD4A mRNA |
CTD |
PMID:20621112 |
|
NCBI chr15:23,666,543...23,879,067
Ensembl chr15:23,665,202...23,878,539
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G |
Scd |
stearoyl-CoA desaturase |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of SCD1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
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G |
Sdf2l1 |
stromal cell-derived factor 2-like 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SDF2L1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
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G |
Sele |
selectin E |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA] |
CTD |
PMID:21971136 |
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NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
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G |
Selenow |
selenoprotein W |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased expression of SELENOW mRNA; Glutathione deficiency promotes the reaction [Methylmercury Compounds results in decreased expression of SELENOW mRNA] |
CTD |
PMID:15823556 |
|
NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681 Ensembl chr 1:77,533,148...77,535,681
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G |
Sesn2 |
sestrin 2 |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of SESN2 mRNA Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of SESN2 protein] |
CTD |
PMID:20621112 PMID:26035713 |
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NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
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G |
Sfxn1 |
sideroflexin 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SFXN1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr17:11,046,588...11,082,219
Ensembl chr17:11,045,761...11,082,047
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G |
Sgk2 |
serum/glucocorticoid regulated kinase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SGK2 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 3:159,361,313...159,385,843
Ensembl chr 3:159,368,273...159,384,775
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G |
Sirt1 |
sirtuin 1 |
multiple interactions decreases abundance |
ISO |
[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] SIRT1 protein results in decreased abundance of Glutathione |
CTD |
PMID:24451382 PMID:29134718 |
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NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions |
ISO |
SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Glutathione] |
CTD |
PMID:12606766 |
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NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
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G |
Slc25a10 |
solute carrier family 25 member 10 |
multiple interactions increases uptake |
EXP |
[SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to S-(1,2-dichlorovinyl)cysteine; [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to tert-Butylhydroperoxide SLC25A10 protein results in increased uptake of Glutathione |
CTD |
PMID:12388626 |
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NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143
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G |
Slc25a20 |
solute carrier family 25 member 20 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Glutathione inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein] |
CTD |
PMID:25849418 |
|
NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
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G |
Slc25a33 |
solute carrier family 25 member 33 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SLC25A33 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:166,701,463...166,726,794
Ensembl chr 5:166,701,465...166,726,794
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G |
Slc31a1 |
solute carrier family 31 member 1 |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper] |
CTD |
PMID:23426973 |
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NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
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G |
Slc39a2 |
solute carrier family 39 member 2 |
multiple interactions |
ISO |
[SLC39A2 protein co-treated with zinc chloride] results in increased abundance of Glutathione |
CTD |
PMID:18385089 |
|
NCBI chr15:28,295,044...28,297,688
Ensembl chr15:28,295,368...28,297,684
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G |
Slc3a2 |
solute carrier family 3 member 2 |
multiple interactions |
ISO |
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione |
CTD |
PMID:22216172 |
|
NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
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G |
Slc5a6 |
solute carrier family 5 member 6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SLC5A6 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases abundance multiple interactions |
ISO |
SLC7A11 results in increased abundance of Glutathione [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Glutathione; [SLC7A11 results in increased abundance of Glutathione] which results in decreased abundance of Reactive Oxygen Species; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione |
CTD |
PMID:19015640 PMID:22216172 PMID:23085521 |
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NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
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G |
Slc9a9 |
solute carrier family 9 member A9 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SLC9A9 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 8:102,304,095...103,022,619
Ensembl chr 8:102,304,095...103,022,619
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G |
Snca |
synuclein alpha |
multiple interactions decreases abundance |
EXP ISO |
Glutathione inhibits the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]] Dopamine inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; geraniol inhibits the reaction [SNCA protein results in decreased abundance of Glutathione] |
CTD |
PMID:23353026 PMID:27026137 PMID:27424009 |
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NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases abundance affects activity affects abundance |
ISO |
[Glutathione results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Glutathione results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]; Glutathione results in increased reduction of and results in decreased activity of SOD1 protein SOD1 gene mutant form results in increased abundance of Glutathione Glutathione deficiency affects the activity of SOD1 protein [GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein]; SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form]; Thioacetamide promotes the reaction [SOD1 gene mutant form results in increased abundance of Glutathione] SOD1 protein affects the abundance of Glutathione |
CTD |
PMID:15707499 PMID:16101137 PMID:16377630 PMID:16636302 PMID:22867017 PMID:27349771 PMID:31162603 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
increases abundance multiple interactions |
ISO |
SOD2 protein results in increased abundance of Glutathione [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA] |
CTD |
PMID:15130278 PMID:16101137 PMID:18594523 PMID:25362599 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions decreases expression |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein] Glutathione results in decreased expression of SP1 |
CTD |
PMID:18556457 PMID:20435036 |
|
NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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G |
Sp3 |
Sp3 transcription factor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein] |
CTD |
PMID:20435036 |
|
NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
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G |
Sp4 |
Sp4 transcription factor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP4 protein] |
CTD |
PMID:20435036 |
|
NCBI chr 6:146,135,877...146,201,344
Ensembl chr 6:146,135,877...146,195,819
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein] |
CTD |
PMID:22927544 |
|
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] |
CTD |
PMID:28803762 |
|
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Srek1ip1 |
SREK1-interacting protein 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of SREK1IP1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 2:34,923,187...34,940,410
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G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SRXN1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein] Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]] |
CTD |
PMID:12847270 PMID:16896058 |
|
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions affects abundance |
ISO |
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]] STAT3 protein affects the abundance of Glutathione |
CTD |
PMID:16896058 PMID:20224768 |
|
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Sult1c2a |
sulfotransferase family, cytosolic, 1C, member 2a |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SULT1C2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 9:4,152,588...4,168,355
Ensembl chr 9:4,152,589...4,168,221
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G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] |
CTD |
PMID:27624276 PMID:28153600 |
|
NCBI chr X:1,321,315...1,379,202
Ensembl chr X:1,321,315...1,379,198
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G |
Taldo1 |
transaldolase 1 |
multiple interactions decreases abundance |
ISO |
Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:19436114 |
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NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
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G |
Tert |
telomerase reverse transcriptase |
increases expression multiple interactions |
ISO |
Glutathione results in increased expression of TERT protein Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein] |
CTD |
PMID:30851366 |
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NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
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G |
Tes |
testin LIM domain protein |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TES mRNA |
CTD |
PMID:20621112 |
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NCBI chr 4:44,321,883...44,360,407
Ensembl chr 4:44,321,883...44,360,405
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G |
Tet1 |
tet methylcytosine dioxygenase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA] |
CTD |
PMID:28153600 |
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NCBI chr20:27,359,122...27,438,039
Ensembl chr20:27,366,213...27,437,427
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases abundance |
EXP |
diphenyleneiodonium inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione]; Rotenone inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione] |
CTD |
PMID:11260395 PMID:14732287 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Thpo |
thrombopoietin |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of THPO mRNA |
CTD |
PMID:20621112 |
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NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910 Ensembl chr11:83,868,655...83,873,910
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G |
Tlr2 |
toll-like receptor 2 |
decreases expression |
ISO |
Glutathione results in decreased expression of TLR2 mRNA |
CTD |
PMID:22385246 |
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NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
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G |
Tlr4 |
toll-like receptor 4 |
decreases expression |
ISO |
Glutathione results in decreased expression of TLR4 mRNA |
CTD |
PMID:22385246 |
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NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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G |
Tmcc1 |
transmembrane and coiled-coil domain family 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TMCC1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 4:147,920,987...148,048,852
Ensembl chr 4:147,921,724...148,048,726
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases abundance decreases expression increases chemical synthesis affects abundance increases abundance |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]; [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; cyanidin 3-O-glucoside inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA] Glutathione affects the reaction [Alcohols results in increased expression of TNF protein] Glutathione results in decreased expression of TNF mRNA TNF protein results in increased chemical synthesis of Glutathione TNF protein affects the abundance of Glutathione TNF protein results in increased abundance of Glutathione |
CTD |
PMID:9374527 PMID:9535218 PMID:10802230 PMID:16219905 PMID:16271621 PMID:17079650 PMID:17640567 PMID:19900513 PMID:20351055 PMID:20626112 PMID:21971136 PMID:22385246 PMID:27793764 PMID:28803762 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tnfaip6 |
TNF alpha induced protein 6 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] |
CTD |
PMID:21220312 |
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NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
affects abundance |
ISO |
TNFRSF1A protein affects the abundance of Glutathione |
CTD |
PMID:20159942 |
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NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] |
CTD |
PMID:21497582 |
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NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases glutathionylation decreases abundance increases expression |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [Doxorubicin results in increased expression of TP53 protein] TP53 protein results in decreased abundance of Glutathione Glutathione results in increased expression of TP53 protein |
CTD |
PMID:10897038 PMID:12807757 PMID:12967322 PMID:17555331 PMID:19202565 PMID:22927544 PMID:27634759 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Tpo |
thyroid peroxidase |
multiple interactions decreases activity |
ISO |
arsenic trioxide promotes the reaction [Glutathione results in decreased activity of TPO protein]; Glutathione promotes the reaction [arsenic trioxide results in decreased activity of TPO protein] |
CTD |
PMID:25595679 |
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NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
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G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TRIB3 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [agathic acid results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [phenalen-1-one results in increased activity of TRPA1 protein] |
CTD |
PMID:23541125 PMID:30945539 |
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NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
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G |
Tsku |
tsukushi, small leucine rich proteoglycan |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TSKU mRNA |
CTD |
PMID:20621112 |
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NCBI chr 1:163,317,281...163,328,697
Ensembl chr 1:163,317,282...163,328,591
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G |
Tubb3 |
tubulin, beta 3 class III |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA] |
CTD |
PMID:28153600 |
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NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
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G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
EXP |
Glutathione affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein] |
CTD |
PMID:17640917 PMID:22694104 PMID:24661219 |
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NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
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G |
Tyr |
tyrosinase |
multiple interactions |
ISO |
[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione; [TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of trans-3-(4'-hydroxyphenyl)-2-propenoic acid] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]; Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester] |
CTD |
PMID:20685355 |
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NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
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G |
Uchl1 |
ubiquitin C-terminal hydrolase L1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein] |
CTD |
PMID:24582816 |
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NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
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G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]; Glutathione inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA] |
CTD |
PMID:12414803 |
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NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] |
CTD |
PMID:19361538 |
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NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A2 mRNA; Glutathione deficiency results in increased expression of UGT1A3 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a3 |
UDP glycosyltransferase 1 family, polypeptide A3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A5 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 9:95,274,707...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A6 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a7c |
UDP glucuronosyltransferase 1 family, polypeptide A7C |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A10 mRNA; Glutathione deficiency results in increased expression of UGT1A7 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a8 |
UDP glucuronosyltransferase family 1 member A8 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A8 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt2b |
UDP glycosyltransferase 2 family, polypeptide B |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT2B4 mRNA |
CTD |
PMID:15345336 |
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Ensembl chr14:22,375,955...22,534,720
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G |
Ugt2b17 |
UDP glucuronosyltransferase family 2 member B17 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT2B1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
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G |
UST4r |
integral membrane transport protein UST4r |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UST4R mRNA |
CTD |
PMID:20621112 |
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NCBI chr 1:224,319,927...224,389,499
Ensembl chr 1:224,319,077...224,389,499
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] |
CTD |
PMID:16271621 PMID:21971136 |
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NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Glutathione inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA] |
CTD |
PMID:11641398 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Vnn1 |
vanin 1 |
affects abundance |
ISO |
VNN1 affects the abundance of Glutathione |
CTD |
PMID:15282320 |
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NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
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G |
Xbp1 |
X-box binding protein 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form] |
CTD |
PMID:24515801 |
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NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
[Xanthine co-treated with XDH protein] results in increased abundance of Glutathione |
CTD |
PMID:7743507 |
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NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Thimerosal results in decreased expression of XIAP protein] |
CTD |
PMID:12140745 |
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NCBI chr X:128,409,425...128,455,786
Ensembl chr X:128,409,472...128,453,000
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G |
Xk |
X-linked Kx blood group |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of XK mRNA |
CTD |
PMID:20621112 |
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NCBI chr X:14,497,376...14,534,479
Ensembl chr X:14,498,119...14,534,473
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G |
Xrcc1 |
X-ray repair cross complementing 1 |
multiple interactions increases oxidation decreases oxidation |
ISO |
Acetylcysteine promotes the reaction [XRCC1 protein results in decreased oxidation of Glutathione] XRCC1 gene mutant form results in increased oxidation of Glutathione |
CTD |
PMID:30998386 |
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NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
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G |
Ywhag |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma |
increases expression |
EXP |
Glutathione deficiency results in increased expression of YWHAG mRNA |
CTD |
PMID:15345336 |
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NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
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G |
Zbtb7b |
zinc finger and BTB domain containing 7B |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of ZBTB7B mRNA |
CTD |
PMID:20621112 |
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NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
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G |
Zfp367 |
zinc finger protein 367 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ZFP367 mRNA |
CTD |
PMID:20621112 |
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NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases export increases activity multiple interactions |
ISO EXP |
ABCC1 protein results in increased export of Glutathione Disulfide Glutathione Disulfide results in increased activity of ABCC1 protein [Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein] ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide] |
CTD |
PMID:11306701 PMID:15628876 PMID:17272743 PMID:19053318 PMID:21918036 |
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NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases transport multiple interactions |
EXP |
ABCC2 protein results in increased transport of Glutathione Disulfide Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide] |
CTD |
PMID:15276087 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Agt |
angiotensinogen |
multiple interactions increases export decreases abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide] AGT protein results in increased export of Glutathione Disulfide |
CTD |
PMID:17272743 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
affects response to substance increases glutathionylation increases activity |
ISO |
ALOX12 protein affects the susceptibility to Glutathione Disulfide Glutathione Disulfide results in increased glutathionylation of ALOX12 protein Glutathione Disulfide results in increased activity of ALOX12 protein |
CTD |
PMID:19373248 |
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NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
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G |
Ar |
androgen receptor |
affects localization multiple interactions |
ISO |
Glutathione Disulfide affects the localization of AR protein Glutathione Disulfide binds to and results in increased activity of AR protein |
CTD |
PMID:28478275 |
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NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Glutathione Disulfide results in increased expression of CDKN1A protein |
CTD |
PMID:15993333 |
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NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cftr |
CF transmembrane conductance regulator |
decreases activity |
ISO |
Glutathione Disulfide results in decreased activity of CFTR protein |
CTD |
PMID:15657297 |
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NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Crygd |
crystallin, gamma D |
increases oxidation |
ISO |
Glutathione Disulfide results in increased oxidation of CRYGD protein mutant form |
CTD |
PMID:30242128 |
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NCBI chr 9:71,776,568...71,778,323
Ensembl chr 9:71,764,318...71,778,323
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G |
Fas |
Fas cell surface death receptor |
decreases activity |
ISO |
Glutathione Disulfide results in decreased activity of FAS protein |
CTD |
PMID:10385654 |
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NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Fndc5 |
fibronectin type III domain containing 5 |
decreases abundance |
EXP |
FNDC5 protein results in decreased abundance of Glutathione Disulfide |
CTD |
PMID:32165127 |
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NCBI chr 5:147,323,240...147,330,266
Ensembl chr 5:147,323,240...147,330,266
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G |
Glrx |
glutaredoxin |
affects response to substance |
ISO |
GLRX protein affects the susceptibility to Glutathione Disulfide |
CTD |
PMID:19373248 |
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NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO EXP |
Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein] arsenic trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; arsenic trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; GSR protein binds to and results in increased reduction of Glutathione Disulfide [[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide |
CTD |
PMID:12114195 PMID:12477282 PMID:19668867 PMID:24634002 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Glutathione Disulfide analog promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Glutathione Disulfide analog promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein] |
CTD |
PMID:19374849 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in increased abundance of Glutathione Disulfide |
CTD |
PMID:31288001 |
|
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO EXP |
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]] Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:12433058 PMID:12477282 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Ngf |
nerve growth factor |
affects abundance |
ISO |
NGF protein affects the abundance of Glutathione Disulfide |
CTD |
PMID:23472850 |
|
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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G |
Nnmt |
nicotinamide N-methyltransferase |
increases abundance |
ISO |
NNMT protein results in increased abundance of Glutathione Disulfide |
CTD |
PMID:31909875 |
|
NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]] Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:12433058 PMID:12477282 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions increases abundance |
ISO |
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [SLC2A4 gene mutant form results in increased abundance of Glutathione Disulfide] |
CTD |
PMID:22221582 |
|
NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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G |
Snca |
synuclein alpha |
decreases abundance |
ISO |
SNCA protein results in decreased abundance of Glutathione Disulfide |
CTD |
PMID:27424009 |
|
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Sod2 |
superoxide dismutase 2 |
increases abundance |
ISO |
SOD2 protein results in increased abundance of Glutathione Disulfide |
CTD |
PMID:15130278 |
|
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions |
EXP |
Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog binds to SULT1A1 protein] |
CTD |
PMID:21130751 |
|
NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases glutathionylation |
ISO |
Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Glutathione Disulfide results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein |
CTD |
PMID:15993333 PMID:17555331 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Kyat1 |
kynurenine aminotransferase 1 |
increases amination |
ISO |
KYAT1 protein results in increased amination of Cystine |
CTD |
PMID:22093698 |
|
NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:19850060 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:19850060 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Slc3a1 |
solute carrier family 3 member 1 |
increases uptake multiple interactions |
ISO |
SLC3A1 protein results in increased uptake of Cystine [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine |
CTD |
PMID:14978168 PMID:18845132 |
|
NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
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G |
Slc3a2 |
solute carrier family 3 member 2 |
multiple interactions |
ISO |
[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine |
CTD |
PMID:19576933 PMID:22216172 |
|
NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
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G |
Slc7a11 |
solute carrier family 7 member 11 |
multiple interactions |
ISO |
[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine |
CTD |
PMID:19576933 PMID:22216172 |
|
NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
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G |
Slc7a9 |
solute carrier family 7 member 9 |
multiple interactions |
ISO |
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine |
CTD |
PMID:14978168 |
|
NCBI chr 1:91,709,034...91,738,492
Ensembl chr 1:91,716,383...91,738,494
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein] |
CTD |
PMID:18487452 |
|
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects localization |
ISO EXP |
lactacystin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; lactacystin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] lactacystin affects the localization of AHR protein |
CTD |
PMID:10722677 PMID:12237327 PMID:17445780 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases localization affects localization multiple interactions |
ISO |
lactacystin results in increased localization of AIFM1 protein lactacystin affects the localization of AIFM1 protein ATRN protein affects the reaction [lactacystin affects the localization of AIFM1 protein]; U 0126 inhibits the reaction [lactacystin results in increased localization of AIFM1 protein] |
CTD |
PMID:16860906 PMID:21683092 |
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NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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G |
Apob |
apolipoprotein B |
multiple interactions increases secretion increases expression |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]; lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein]; lactacystin results in increased expression of and results in increased secretion of APOB protein |
CTD |
PMID:15618547 PMID:19383982 |
|
NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
lactacystin inhibits the reaction [resveratrol results in decreased secretion of APP protein] |
CTD |
PMID:16162502 |
|
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Atp1a1 |
ATPase Na+/K+ transporting subunit alpha 1 |
multiple interactions |
EXP |
lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein] |
CTD |
PMID:10506578 |
|
NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
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G |
Atrn |
attractin |
multiple interactions decreases response to substance |
ISO |
ATRN protein affects the reaction [lactacystin affects the localization of AIFM1 protein] ATRN protein results in decreased susceptibility to lactacystin |
CTD |
PMID:16860906 |
|
NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
EXP ISO |
lactacystin results in decreased expression of BCL2 protein lactacystin inhibits the reaction [sodium bichromate results in decreased expression of BCL2 protein] lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]; Sirolimus inhibits the reaction [lactacystin results in decreased expression of BCL2 protein] |
CTD |
PMID:18544562 PMID:18640276 PMID:19361538 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Acetaminophen results in decreased expression of BCL2L1 protein] |
CTD |
PMID:15673306 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Casp3 |
caspase 3 |
increases activity increases expression multiple interactions |
EXP ISO |
lactacystin results in increased activity of CASP3 protein lactacystin results in increased expression of CASP3 protein modified form [lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein; calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein] |
CTD |
PMID:15618349 PMID:20649845 PMID:21683092 PMID:29944914 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] |
CTD |
PMID:20671745 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein] |
CTD |
PMID:18156803 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] |
CTD |
PMID:18156803 |
|
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
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G |
Ccs |
copper chaperone for superoxide dismutase |
multiple interactions |
ISO EXP |
lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] lactacystin inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein] |
CTD |
PMID:12832419 PMID:19039664 |
|
NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions |
ISO |
lactacystin results in increased expression of CDKN1B protein lactacystin inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein] |
CTD |
PMID:12149143 PMID:17283133 PMID:23029392 |
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NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression |
ISO |
lactacystin results in increased expression of CEBPB protein |
CTD |
PMID:11779194 |
|
NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
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G |
Cebpd |
CCAAT/enhancer binding protein delta |
increases expression |
ISO |
lactacystin results in increased expression of CEBPD protein |
CTD |
PMID:11779194 |
|
NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
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G |
Comt |
catechol-O-methyltransferase |
multiple interactions |
ISO |
lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein] |
CTD |
PMID:17138778 |
|
NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
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G |
Cp |
ceruloplasmin |
decreases degradation |
ISO |
lactacystin results in decreased degradation of CP protein |
CTD |
PMID:16405854 |
|
NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Indomethacin results in decreased expression of CTNNB1 protein]; lactacystin inhibits the reaction [resveratrol results in increased degradation of CTNNB1 protein] |
CTD |
PMID:11756231 PMID:26040106 |
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NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:10722677 PMID:10777561 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
lactacystin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] |
CTD |
PMID:24792400 |
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NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA] |
CTD |
PMID:24224465 |
|
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
lactacystin inhibits the reaction [Dexamethasone results in increased expression of CYP3A23-3A1 protein] |
CTD |
PMID:17083955 |
|
NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:24224465 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
lactacystin results in increased expression of DDIT3 mRNA |
CTD |
PMID:19135031 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Dio2 |
iodothyronine deiodinase 2 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]; lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; lactacystin results in increased expression of and results in increased activity of DIO2 protein |
CTD |
PMID:11425850 |
|
NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] |
CTD |
PMID:15878868 |
|
NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Dronabinol results in decreased expression of ERBB2 protein] |
CTD |
PMID:30733293 |
|
NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
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G |
Fzr1 |
fizzy and cell division cycle 20 related 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Estradiol affects the localization of FZR1 protein] |
CTD |
PMID:23029392 |
|
NCBI chr 7:11,201,690...11,213,614
Ensembl chr 7:11,201,690...11,213,613
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] |
CTD |
PMID:22150760 |
|
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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G |
Gls |
glutaminase |
multiple interactions |
ISO |
lactacystin inhibits the reaction [diphenylarsinic acid results in increased degradation of GLS protein alternative form] |
CTD |
PMID:22493432 |
|
NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
increases localization |
EXP |
lactacystin results in increased localization of GRIA1 protein |
CTD |
PMID:19674091 |
|
NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
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G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
increases localization |
EXP |
lactacystin results in increased localization of GRIA2 protein |
CTD |
PMID:19674091 |
|
NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
ISO |
lactacystin results in increased expression of GSTA2 mRNA |
CTD |
PMID:12446695 |
|
NCBI chr 8:85,640,081...85,645,621
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] |
CTD |
PMID:11980636 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP ISO |
lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; lactacystin promotes the reaction [manganese chloride results in increased expression of HMOX1 protein] lactacystin results in increased expression of HMOX1 mRNA |
CTD |
PMID:12441344 PMID:21384399 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hpx |
hemopexin |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] |
CTD |
PMID:19039664 |
|
NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
lactacystin results in increased activity of HSF1 protein |
CTD |
PMID:11893605 |
|
NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
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G |
Hsf2 |
heat shock transcription factor 2 |
increases activity |
ISO |
lactacystin results in increased activity of HSF2 protein |
CTD |
PMID:11893605 |
|
NCBI chr20:38,935,820...38,963,444
Ensembl chr20:38,935,820...38,963,309
|
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]; lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein] |
CTD |
PMID:15618547 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
|
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA] lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein] |
CTD |
PMID:22398747 PMID:25766886 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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|
G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA] |
CTD |
PMID:22398747 |
|
NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein] |
CTD |
PMID:25766886 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA] |
CTD |
PMID:22398747 |
|
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA] |
CTD |
PMID:22398747 |
|
NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 mRNA] |
CTD |
PMID:22398747 |
|
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
lactacystin results in increased expression of IL6 mRNA; lactacystin results in increased expression of IL6 protein Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 protein] |
CTD |
PMID:11893605 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
lactacystin promotes the reaction [Tretinoin results in increased expression of ITGAM protein] |
CTD |
PMID:20945414 |
|
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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G |
Lamb1 |
laminin subunit beta 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] |
CTD |
PMID:22150760 |
|
NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases activity multiple interactions |
ISO |
lactacystin results in increased activity of MAPK1 protein U 0126 inhibits the reaction [lactacystin results in increased activity of MAPK1 protein] |
CTD |
PMID:21683092 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases activity multiple interactions |
ISO |
lactacystin results in increased activity of MAPK3 protein U 0126 inhibits the reaction [lactacystin results in increased activity of MAPK3 protein] |
CTD |
PMID:21683092 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases activity increases phosphorylation |
ISO EXP |
lactacystin results in increased activity of MAPK8 protein lactacystin results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:15618349 PMID:18463101 |
|
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mapk8ip1 |
mitogen-activated protein kinase 8 interacting protein 1 |
increases expression |
ISO EXP |
lactacystin results in increased expression of MAPK8IP1 protein |
CTD |
PMID:15618349 |
|
NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
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G |
Mttp |
microsomal triglyceride transfer protein |
increases ubiquitination |
ISO |
lactacystin results in increased ubiquitination of MTTP protein |
CTD |
PMID:17405876 |
|
NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
increases expression decreases degradation multiple interactions |
ISO EXP |
lactacystin results in increased expression of NFE2L2 protein lactacystin results in decreased degradation of NFE2L2 protein lactacystin promotes the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein] lactacystin promotes the reaction [manganese chloride affects the localization of and results in increased activity of NFE2L2 protein]; lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]] |
CTD |
PMID:12441344 PMID:12446695 PMID:15322212 PMID:21384399 PMID:26598004 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
lactacystin promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:17644113 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nol3 |
nucleolar protein 3 |
multiple interactions |
EXP |
lactacystin affects the reaction [Doxorubicin results in increased degradation of NOL3 protein] |
CTD |
PMID:19139834 |
|
NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]] lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [deoxynivalenol results in increased degradation of NOS2 protein]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein] |
CTD |
PMID:17891158 PMID:19376148 PMID:25766886 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
decreases activity multiple interactions |
ISO |
lactacystin results in decreased activity of NR1I3 protein lactacystin inhibits the reaction [Phenobarbital affects the localization of NR1I3 protein] |
CTD |
PMID:24224465 |
|
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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G |
Optn |
optineurin |
increases expression multiple interactions |
EXP ISO |
lactacystin results in increased expression of OPTN protein lactacystin results in increased expression of and results in increased ubiquitination of OPTN protein |
CTD |
PMID:21059646 |
|
NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
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G |
Otc |
ornithine transcarbamylase |
multiple interactions decreases metabolic processing |
ISO |
lactacystin inhibits the reaction [Oxygen results in decreased metabolism of OTC protein] lactacystin results in decreased metabolism of OTC protein |
CTD |
PMID:11161710 |
|
NCBI chr X:13,524,804...13,601,074
Ensembl chr X:13,524,607...13,601,069
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G |
Park7 |
Parkinsonism associated deglycase |
decreases response to substance |
ISO |
PARK7 protein results in decreased susceptibility to lactacystin |
CTD |
PMID:18331584 |
|
NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
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G |
Pdia2 |
protein disulfide isomerase family A, member 2 |
increases expression |
ISO |
lactacystin results in increased expression of PDIA2 mRNA; lactacystin results in increased expression of PDIA2 protein |
CTD |
PMID:15353226 |
|
|
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G |
Pfkfb3 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
increases expression |
EXP |
lactacystin results in increased expression of PFKFB3 protein |
CTD |
PMID:19448625 |
|
NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
ISO |
lactacystin results in increased expression of PPP1R15A mRNA |
CTD |
PMID:19135031 |
|
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
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G |
Prkcb |
protein kinase C, beta |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] |
CTD |
PMID:17644113 |
|
NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
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G |
Psmb10 |
proteasome 20S subunit beta 10 |
multiple interactions |
ISO |
[PSMB8 protein co-treated with PSMB10 protein] affects the susceptibility to lactacystin |
CTD |
PMID:22398747 |
|
NCBI chr19:37,909,543...37,912,027
Ensembl chr19:37,909,546...37,912,027
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G |
Psmb8 |
proteasome 20S subunit beta 8 |
multiple interactions |
ISO |
[PSMB8 protein co-treated with PSMB10 protein] affects the susceptibility to lactacystin |
CTD |
PMID:22398747 |
|
NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769
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G |
Psmd4 |
proteasome 26S subunit, non-ATPase 4 |
multiple interactions |
ISO |
lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] |
CTD |
PMID:15362974 |
|
NCBI chr 2:196,198,303...196,207,569
Ensembl chr 2:196,198,038...196,207,560
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G |
Rbpj |
recombination signal binding protein for immunoglobulin kappa J region |
increases expression |
ISO |
lactacystin results in increased expression of RBPJ protein |
CTD |
PMID:22302987 |
|
NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein] |
CTD |
PMID:17644113 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]] |
CTD |
PMID:18344023 |
|
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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G |
Skp2 |
S-phase kinase associated protein 2 |
multiple interactions decreases expression |
ISO |
lactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein] lactacystin results in decreased expression of SKP2 protein |
CTD |
PMID:23029392 |
|
NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
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G |
Slc10a2 |
solute carrier family 10 member 2 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein] |
CTD |
PMID:24498857 |
|
NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
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G |
Slc31a1 |
solute carrier family 31 member 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] |
CTD |
PMID:17108132 |
|
NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
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G |
Slc38a3 |
solute carrier family 38, member 3 |
multiple interactions |
EXP |
lactacystin inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] |
CTD |
PMID:20737472 |
|
NCBI chr 8:116,406,258...116,423,752
Ensembl chr 8:116,406,241...116,422,366
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G |
Snca |
synuclein alpha |
multiple interactions decreases expression |
ISO EXP |
lactacystin promotes the reaction [SNCA protein mutant form binds to SNCA protein mutant form] lactacystin results in decreased expression of SNCA protein |
CTD |
PMID:16584840 PMID:18818210 |
|
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions affects localization |
ISO |
lactacystin inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein] lactacystin affects the localization of SOD1 protein mutant form Copper promotes the reaction [lactacystin affects the localization of SOD1 protein mutant form]; Ditiocarb inhibits the reaction [lactacystin affects the localization of SOD1 protein mutant form] |
CTD |
PMID:15034941 PMID:17309078 |
|
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sptan1 |
spectrin, alpha, non-erythrocytic 1 |
multiple interactions increases cleavage |
ISO |
[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein; calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein] |
CTD |
PMID:21683092 |
|
NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
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G |
Stk11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein] |
CTD |
PMID:21191146 |
|
NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
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G |
Syp |
synaptophysin |
multiple interactions |
EXP |
lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein] |
CTD |
PMID:18487452 |
|
NCBI chr X:15,694,699...15,709,244
Ensembl chr X:15,695,566...15,707,436
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G |
Tbx21 |
T-box transcription factor 21 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA] |
CTD |
PMID:22398747 |
|
NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]] |
CTD |
PMID:18344023 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tiparp |
TCDD-inducible poly(ADP-ribose) polymerase |
multiple interactions |
ISO |
lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] |
CTD |
PMID:12147270 |
|
NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein] lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF mRNA]; lactacystin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:17138778 PMID:18809656 PMID:22398747 PMID:25766886 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tomm20 |
translocase of outer mitochondrial membrane 20 |
affects localization |
ISO |
lactacystin affects the localization of TOMM20 protein |
CTD |
PMID:11161710 |
|
NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases ubiquitination |
EXP |
lactacystin inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]; lactacystin results in increased phosphorylation of and results in increased expression of TP53 protein lactacystin results in increased ubiquitination of TP53 protein |
CTD |
PMID:16330492 PMID:18463101 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Tp63 |
tumor protein p63 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]; lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form] |
CTD |
PMID:21191146 |
|
NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
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G |
Tsc22d3 |
TSC22 domain family, member 3 |
multiple interactions |
ISO |
lactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] |
CTD |
PMID:20671745 |
|
NCBI chr X:111,884,285...111,944,693
Ensembl chr X:111,884,295...111,887,906
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G |
Ubxn1 |
UBX domain protein 1 |
multiple interactions |
ISO |
lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] |
CTD |
PMID:15362974 |
|
NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
EXP |
lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein] |
CTD |
PMID:19361538 |
|
NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
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G |
Vcp |
valosin-containing protein |
multiple interactions increases expression |
ISO |
lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] lactacystin results in increased expression of VCP protein |
CTD |
PMID:15362974 |
|
NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
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G |
Vdr |
vitamin D receptor |
decreases degradation |
ISO |
lactacystin results in decreased degradation of VDR protein |
CTD |
PMID:24792400 |
|
NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
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G |
Xbp1 |
X-box binding protein 1 |
decreases response to substance |
ISO |
XBP1 protein results in decreased susceptibility to lactacystin |
CTD |
PMID:19135031 |
|
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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|
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]] [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4 |
CTD |
PMID:8621850 PMID:10764316 PMID:12794006 |
|
NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
|
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G |
Cysltr1 |
cysteinyl leukotriene receptor 1 |
affects binding multiple interactions |
ISO |
Leukotriene E4 binds to CYSLTR1 protein [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein] |
CTD |
PMID:8384568 PMID:9620942 PMID:10462554 PMID:11705452 PMID:12853847 |
|
NCBI chr X:77,671,028...77,700,491
Ensembl chr X:77,674,150...77,700,269
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G |
Cysltr2 |
cysteinyl leukotriene receptor 2 |
multiple interactions increases activity |
ISO |
[Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene E4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein |
CTD |
PMID:10851239 PMID:11093801 |
|
NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203
|
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G |
Gpr17 |
G protein-coupled receptor 17 |
increases activity |
ISO |
Leukotriene E4 results in increased activity of GPR17 protein |
CTD |
PMID:18974869 |
|
NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349
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G |
Il13 |
interleukin 13 |
increases abundance |
EXP |
IL13 protein results in increased abundance of Leukotriene E4 |
CTD |
PMID:12654629 |
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NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
decreases activity |
EXP |
Leukotriene E4 results in decreased activity of MGST1 protein |
CTD |
PMID:9890956 |
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NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
increases expression |
EXP |
Leukotriene E4 results in increased expression of MUC5AC protein |
CTD |
PMID:12654629 |
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NCBI chr 1:214,725,482...214,756,653
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions |
ISO |
PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene E4] |
CTD |
PMID:25432964 |
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NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
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G |
A1bg |
alpha-1-B glycoprotein |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of A1BG mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of A1BG mRNA] |
CTD |
PMID:22129741 |
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NCBI chr 7:102,294,805...102,298,522
Ensembl chr 7:102,294,797...102,298,522
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased methylation of ABCA1 promoter] |
CTD |
PMID:31150806 |
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NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO EXP |
Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA] Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ABCB1]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] |
CTD |
PMID:10636889 PMID:18474546 PMID:22914566 PMID:23867903 PMID:25824409 |
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NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC1 protein]; Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]] |
CTD |
PMID:11820781 PMID:15473893 PMID:22914566 PMID:23867903 |
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NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA] |
CTD |
PMID:22914566 PMID:23867903 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC3 protein] |
CTD |
PMID:11820781 |
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NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
decreases expression |
ISO |
Acetylcysteine results in decreased expression of ABCG1 mRNA |
CTD |
PMID:16084531 |
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NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
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G |
Abcg4 |
ATP binding cassette subfamily G member 4 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA] |
CTD |
PMID:22129741 |
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NCBI chr 8:48,604,915...48,626,219
Ensembl chr 8:48,606,403...48,619,592
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of ABL1 protein] |
CTD |
PMID:16481037 |
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NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
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G |
Ache |
acetylcholinesterase |
multiple interactions affects response to substance |
EXP ISO |
[Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Cadmium results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein] ACHE protein affects the susceptibility to Acetylcysteine Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of ACHE mRNA alternative form]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of ACHE protein] |
CTD |
PMID:20399762 PMID:20688495 PMID:26769589 PMID:27087133 PMID:27163631 PMID:28499986 PMID:29253600 PMID:30639957 PMID:31173782 |
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NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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G |
Acp3 |
acid phosphatase 3 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACP3 mRNA |
CTD |
PMID:22129741 |
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NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
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G |
Acsm5 |
acyl-CoA synthetase medium-chain family member 5 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSM5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ACSM5 mRNA] |
CTD |
PMID:22129741 |
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NCBI chr 1:189,240,955...189,270,422
Ensembl chr 1:189,233,141...189,272,172
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G |
Acss1 |
acyl-CoA synthetase short-chain family member 1 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSS1 mRNA |
CTD |
PMID:22129741 |
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NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein] |
CTD |
PMID:16757516 PMID:21134390 PMID:32659284 |
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NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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G |
Adam33 |
ADAM metallopeptidase domain 33 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ADAM33 mRNA] |
CTD |
PMID:29753051 |
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NCBI chr 3:123,595,018...123,607,549
Ensembl chr 3:123,595,560...123,607,352
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G |
Adgrb2 |
adhesion G protein-coupled receptor B2 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB2 mRNA |
CTD |
PMID:22129741 |
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NCBI chr 5:148,168,530...148,231,587
Ensembl chr 5:148,193,710...148,231,587
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G |
Adgrb3 |
adhesion G protein-coupled receptor B3 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB3 mRNA |
CTD |
PMID:22129741 |
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NCBI chr 9:31,280,623...32,022,535
Ensembl chr 9:31,281,316...32,019,205
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G |
Adh1 |
alcohol dehydrogenase 1 (class I) |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Ethanol results in increased expression of ADH1 mRNA] |
CTD |
PMID:20705415 |
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NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]] |
CTD |
PMID:17471172 PMID:21912612 |
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NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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G |
Adipor2 |
adiponectin receptor 2 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]] |
CTD |
PMID:21912612 |
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NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP ISO |
Acetylcysteine inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein] Acetylcysteine inhibits the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:15849355 PMID:30703374 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA] |
CTD |
PMID:23603059 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression multiple interactions |
ISO |
Acetylcysteine results in increased expression of AHR protein Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of and affects the localization of AHR protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1A enhancer]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1B enhancer] |
CTD |
PMID:18022818 PMID:21569840 PMID:31551408 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO EXP |
Acetylcysteine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein] Acetylcysteine inhibits the reaction [bisphenol A affects the localization of AIFM1 protein] Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of AIFM1 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein] |
CTD |
PMID:18034189 PMID:18412143 PMID:18506790 PMID:18951928 PMID:19679660 PMID:21741372 PMID:27189055 PMID:31518672 |
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NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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G |
Aimp1 |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 |
decreases expression |
ISO |
Acetylcysteine results in decreased expression of AIMP1 mRNA |
CTD |
PMID:16084531 |
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NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378
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G |
Akr1b8 |
aldo-keto reductase family 1, member B8 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [arsenite results in increased expression of AKR1B8 protein] |
CTD |
PMID:15175009 |
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NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA] |
CTD |
PMID:18829485 PMID:21787718 |
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NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of and affects the localization of AKT1 protein]; Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [divinyl sulfone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Morpholines analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [N-arachidonoylalanine results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [oenothein B results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [synaptamide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein] Acetylcysteine inhibits the reaction [cadmium acetate results in decreased expression of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AKT1 mRNA] |
CTD |
PMID:12168106 PMID:12614848 PMID:16137721 PMID:16731823 PMID:21055460 PMID:21195169 PMID:21787718 PMID:22427991 PMID:22867088 PMID:23000059 PMID:23159718 PMID:23948867 PMID:24299490 PMID:24449419 PMID:24489685 PMID:24582688 PMID:24875536 PMID:24933620 PMID:25199686 PMID:25471227 PMID:25939952 PMID:25944616 PMID:26514923 PMID:26804764 PMID:26942697 PMID:27106530 PMID:27117918 PMID:27411387 PMID:27658547 PMID:28087840 PMID:28600122 PMID:29604266 PMID:30265530 PMID:30452899 PMID:30797898 PMID:30871965 PMID:31068539 PMID:31157476 PMID:32305283 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP |
Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]] |
CTD |
PMID:16959597 |
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NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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G |
Alb |
albumin |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in decreased expression of MFN2 protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in increased abundance of Hydrogen Peroxide]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [Mustard Gas results in increased expression of ALB protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]] |
CTD |
PMID:11428623 PMID:20804811 PMID:24485406 PMID:27997345 |
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NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] |
CTD |
PMID:17585900 |
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NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
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G |
Alk |
ALK receptor tyrosine kinase |
multiple interactions |
ISO |
Acetylcysteine affects the phosphorylation of and affects the activity of ALK protein mutant form |
CTD |
PMID:19503098 |
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NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775
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G |
Amacr |
alpha-methylacyl-CoA racemase |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA] |
CTD |
PMID:18829485 |
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NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
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G |
Ang |
angiogenin |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of ANG protein] |
CTD |
PMID:26138014 |
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NCBI chr15:28,022,926...28,028,636
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G |
Angpt1 |
angiopoietin 1 |
decreases secretion |
ISO |
Acetylcysteine results in decreased secretion of ANGPT1 protein |
CTD |
PMID:19622383 |
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NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
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G |
Angptl4 |
angiopoietin-like 4 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANGPTL4 mRNA |
CTD |
PMID:22129741 |
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NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
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G |
Ankrd29 |
ankyrin repeat domain 29 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANKRD29 mRNA |
CTD |
PMID:22129741 |
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NCBI chr18:3,673,915...3,676,187
Ensembl chr18:3,673,915...3,676,188
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G |
Aoc1 |
amine oxidase, copper containing 1 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] |
CTD |
PMID:20885979 |
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NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein] |
CTD |
PMID:15877105 PMID:19477266 |
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NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein] Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA] |
CTD |
PMID:12231548 PMID:17938202 |
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NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
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G |
Apex2 |
apurinic/apyrimidinic endodeoxyribonuclease 2 |
multiple interactions decreases expression |
EXP |
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA] Acetylcysteine results in decreased expression of APEX2 mRNA |
CTD |
PMID:26332274 |
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NCBI chr X:23,146,085...23,166,676
Ensembl chr X:23,146,085...23,166,675
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G |
Aph1b |
aph-1 homolog B, gamma secretase subunit |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of APH1B mRNA |
CTD |
PMID:22129741 |
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NCBI chr 8:72,508,008...72,598,921
Ensembl chr 8:72,476,425...72,629,265
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of NLRP3 protein] |
CTD |
PMID:12684028 PMID:28004443 |
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NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Aqp2 |
aquaporin 2 |
increases expression |
EXP |
Acetylcysteine results in increased expression of AQP2 protein |
CTD |
PMID:23183129 |
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NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [SOD2 protein affects the activity of AR protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR mRNA]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR protein] |
CTD |
PMID:16928829 PMID:18829485 |
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NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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G |
Arl13a |
ADP ribosylation factor like GTPase 13A |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARL13A mRNA |
CTD |
PMID:22129741 |
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NCBI chr X:105,010,943...105,039,720
Ensembl chr X:105,011,489...105,037,801
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein] |
CTD |
PMID:16880289 |
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NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
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G |
Arntl |
aryl hydrocarbon receptor nuclear translocator-like |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARNTL mRNA |
CTD |
PMID:22129741 |
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NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
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G |
Arrdc3 |
arrestin domain containing 3 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARRDC3 mRNA |
CTD |
PMID:22129741 |
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NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
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G |
Art4 |
ADP-ribosyltransferase 4 |
decreases expression |
ISO |
Acetylcysteine results in decreased expression of ART4 mRNA |
CTD |
PMID:16084531 |
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NCBI chr 4:170,830,851...170,841,187
Ensembl chr 4:170,830,851...170,841,187
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASNS mRNA |
CTD |
PMID:22129741 |
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NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
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G |
Astl |
astacin like metalloendopeptidase |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASTL mRNA |
CTD |
PMID:22129741 |
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NCBI chr 3:119,783,717...119,799,450
Ensembl chr 3:119,783,717...119,799,450
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein] Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:19654923 PMID:22288910 |
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NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
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G |
Atf3 |
activating transcription factor 3 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of and affects the localization of ATF3 protein] |
CTD |
PMID:25531190 |
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NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions decreases expression increases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein] Acetylcysteine results in decreased expression of ATF4 protein Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of ATF4 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA] Acetylcysteine results in increased expression of ATF4 protein |
CTD |
PMID:15788408 PMID:19722195 PMID:21266191 PMID:24291486 PMID:25451595 PMID:25568320 PMID:27484784 PMID:27634458 PMID:27816613 PMID:28754437 PMID:31330229 PMID:32578922 |
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NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO EXP |
Acetylcysteine results in increased metabolism of and results in increased activity of ATF6 protein Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein] Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF6 protein] |
CTD |
PMID:18077580 PMID:19722195 PMID:21198628 PMID:21911445 PMID:24291486 PMID:25451595 PMID:31330229 |
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NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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G |
Atg10 |
autophagy related 10 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA] |
CTD |
PMID:24614525 |
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NCBI chr 2:19,853,546...20,152,918
Ensembl chr 2:19,853,546...20,152,884
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G |
Atg12 |
autophagy related 12 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG12 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG12 mRNA]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]] Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA] |
CTD |
PMID:20543569 PMID:24614525 PMID:29307831 PMID:30205151 |
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NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
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G |
Atg16l1 |
autophagy related 16-like 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG16L1 protein] |
CTD |
PMID:30205151 |
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NCBI chr 9:94,879,876...94,915,231
Ensembl chr 9:94,879,745...94,915,228
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G |
Atg4a |
autophagy related 4A, cysteine peptidase |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ATG4A protein] |
CTD |
PMID:29179951 |
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NCBI chr X:112,328,907...112,403,157
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G |
Atg5 |
autophagy related 5 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG5 mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]] Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA] |
CTD |
PMID:20543569 PMID:24614525 PMID:28600122 PMID:29307831 PMID:30205151 |
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NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
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G |
Atg7 |
autophagy related 7 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATG7 mRNA]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG7 mRNA] |
CTD |
PMID:29247770 PMID:29307831 PMID:30205151 PMID:31319114 |
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NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein]; Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of ATM protein modified form]; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein] Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATM protein] Acetylcysteine results in increased phosphorylation of ATM protein |
CTD |
PMID:15489221 PMID:23274516 PMID:24792323 PMID:26451628 PMID:31168028 PMID:31715134 PMID:32142722 |
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NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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G |
Atp1a1 |
ATPase Na+/K+ transporting subunit alpha 1 |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein] |
CTD |
PMID:10506578 |
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NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
increases expression multiple interactions |
ISO EXP |
Acetylcysteine results in increased expression of ATP2A2 mRNA Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of ATP2A2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein] |
CTD |
PMID:10625299 PMID:16084531 PMID:17005195 |
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NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
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G |
Atp6v0d1 |
ATPase H+ transporting V0 subunit D1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATP6V0D1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATP6V0D1 mRNA] |
CTD |
PMID:29307831 PMID:31319114 |
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NCBI chr19:37,481,782...37,525,762
Ensembl chr19:37,481,782...37,525,762
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G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
multiple interactions |
EXP ISO |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ATP6V0D2 mRNA [Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] |
CTD |
PMID:22129741 PMID:30742845 |
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NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
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G |
Atr |
ATR serine/threonine kinase |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein] |
CTD |
PMID:26451628 |
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NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
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G |
Atxn1 |
ataxin 1 |
affects localization multiple interactions |
ISO |
Acetylcysteine affects the localization of ATXN1 protein mutant form Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form] |
CTD |
PMID:12893416 |
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NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
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G |
Aurkb |
aurora kinase B |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of AURKB protein] |
CTD |
PMID:28343997 |
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NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
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G |
B2m |
beta-2 microglobulin |
decreases response to substance multiple interactions |
ISO |
Acetylcysteine results in decreased susceptibility to B2M protein modified form Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:21864514 |
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NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
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G |
B3galt5 |
Beta-1,3-galactosyltransferase 5 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GALT5 mRNA |
CTD |
PMID:22129741 |
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NCBI chr11:36,638,067...36,683,915
Ensembl chr11:36,634,662...36,683,672
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G |
B3gnt9 |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 |
multiple interactions |
EXP |
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GNT9 mRNA |
CTD |
PMID:22129741 |
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NCBI chr19:37,208,061...37,212,400
Ensembl chr19:37,208,825...37,210,412
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G |
Bach1 |
BTB domain and CNC homolog 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [arsenic trioxide affects the localization of BACH1 protein] |
CTD |
PMID:19350554 |
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NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions increases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAD protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BAD protein] Acetylcysteine results in increased expression of BAD mRNA |
CTD |
PMID:21310227 PMID:22245127 PMID:26332274 |
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NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
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G |
Bag3 |
BAG cochaperone 3 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA] |
CTD |
PMID:18723479 |
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NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions |
EXP ISO |
Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithio |