cyclohexanols - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	cyclohexanols	go back to main search page
Accession:	CHEBI:23480	browse the term
Definition:	An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.
Synonyms:	xref_mesh:	MESH:D003511

show annotations for term's descendants Sort by:
Rat (235 ) Mouse (236 ) Human (236 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (235)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

[Diethylnitrosamine co-treated with Cyclohexanols] results in decreased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

ezrin

increases expression

ISO

Cyclohexanols results in increased expression of EZR mRNA

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

glutathione S-transferase pi 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

marker of proliferation Ki-67

multiple interactions

EXP

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

proliferating cell nuclear antigen

multiple interactions

EXP

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases phosphorylation

EXP

CP55940 increases phosphorylation of Akt1 protein in mast cells

RGD

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

EXP

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

EXP

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

Tramadol results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

decreases activity

EXP

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

caspase 3

affects activity
multiple interactions
increases expression
decreases activity

ISO
EXP

Tramadol affects the activity of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

creatine kinase B

decreases expression
multiple interactions

ISO
EXP

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

ISO

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing

ISO

CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

desmin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

dopamine receptor D2

increases expression

EXP

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

increases expression

EXP

Tramadol results in increased expression of DRD3 protein

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

gap junction protein, alpha 1

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases expression

EXP

Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

EXP

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

5-hydroxytryptamine receptor 2A

increases activity
increases expression
multiple interactions

EXP

Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

interferon gamma

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

lactate dehydrogenase A

decreases expression

ISO

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

ISO

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605

G

opioid receptor, delta 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, kappa 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671

G

opioid receptor, mu 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

pyruvate dehydrogenase kinase 3

increases expression

ISO

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:62,480,535...62,547,371
Ensembl chr X:62,480,535...62,547,371

G

prodynorphin

decreases expression

EXP

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

solute carrier family 2 member 4

multiple interactions

EXP

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 47 member 1

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

superoxide dismutase 1

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
decreases expression

EXP

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

secreted phosphoprotein 1

multiple interactions
increases expression

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

tumor necrosis factor

multiple interactions
increases expression

EXP

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

troponin I3, cardiac type

multiple interactions
increases expression

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

vimentin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 4

multiple interactions

EXP

SB 239063 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098

G

activating transcription factor 4

multiple interactions

ISO

SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

BCL2, apoptosis regulator

multiple interactions

EXP

SB 239063 inhibits the reaction [Particulate Matter results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

ISO

SB 239063 inhibits the reaction [prostaglandin E2 glyceryl ester results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

EXP

SB 239063 inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

DNA-damage inducible transcript 3

multiple interactions

ISO

SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dynamin 1-like

multiple interactions

EXP

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of DNM1L protein

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

dual specificity phosphatase 1

multiple interactions

ISO

SB 239063 inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in decreased expression of DUSP1 protein]]

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

endothelin receptor type B

multiple interactions

EXP

SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]; SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB protein]

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

glutathione peroxidase 1

multiple interactions

ISO

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ovalbumin promotes the reaction [Ozone results in increased activity of GPX1 protein]]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

heat shock protein family B (small) member 1

multiple interactions

ISO

SB 239063 inhibits the reaction [[[Air Pollutants results in increased abundance of Ozone] which co-treated with Ovalbumin] results in increased phosphorylation of HSPB1 protein]

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

interferon gamma

multiple interactions

ISO

SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 13

multiple interactions

ISO

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]; SB 239063 inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]

PMID:25287866 PMID:29284473

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 17A

multiple interactions

ISO

SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A mRNA]]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 6

multiple interactions

ISO

SB 239063 inhibits the reaction [Ovalbumin results in increased expression of IL6 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL6 protein]]

PMID:25287866 PMID:29284473

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 1

multiple interactions

EXP

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

multiple interactions

ISO

SB 239063 inhibits the reaction [[[Air Pollutants results in increased abundance of Ozone] which co-treated with Ovalbumin] results in increased phosphorylation of MAPK14 protein]; SB 239063 inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in increased phosphorylation of MAPK14 protein]]; SB 239063 inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased phosphorylation of MAPK14 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased phosphorylation of MAPK14 protein]]

PMID:24188200 PMID:25287866 PMID:29284473

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions

EXP

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitochondrial fission factor

multiple interactions

EXP

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of MFF protein

NCBI chr 9:91,455,931...91,484,171
Ensembl chr 9:91,455,871...91,484,171

G

peroxisome proliferator-activated receptor gamma

multiple interactions

EXP

SB 239063 inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of PPARG protein]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions

EXP

SB 239063 inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of PPARGC1A protein]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

sequestosome 1

multiple interactions

EXP

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

EXP

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

EXP

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

Tramadol results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

decreases activity

EXP

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

caspase 3

affects activity
increases expression
multiple interactions
decreases activity

ISO
EXP

Tramadol affects the activity of CASP3 protein
Tramadol results in increased expression of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

creatine kinase B

decreases expression
multiple interactions

ISO
EXP

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

cAMP responsive element binding protein 1

increases phosphorylation

EXP

tramadol increases phosphorylation of Creb1 protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

ISO

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases response to substance
affects methylation
increases metabolic processing
decreases methylation
multiple interactions
affects response to substance
decreases response to substance
affects metabolic processing

ISO

CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 protein affects the methylation of Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

desmin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

dopamine receptor D2

increases expression

EXP

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

increases expression

EXP

Tramadol results in increased expression of DRD3 protein

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Tramadol increases expression of Fosb protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

gap junction protein, alpha 1

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glutamic-oxaloacetic transaminase 1

increases expression
multiple interactions

EXP

Tramadol results in increased expression of GOT1 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

EXP

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

5-hydroxytryptamine receptor 2A

multiple interactions
increases activity
increases expression

EXP

Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol results in increased expression of HTR2A mRNA

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

interferon gamma

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

lactate dehydrogenase A

decreases expression

ISO

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

ISO

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605

G

opioid receptor, delta 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, kappa 1

multiple interactions
affects binding

EXP

[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671

G

opioid receptor, mu 1

multiple interactions
affects binding

EXP

[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

pyruvate dehydrogenase kinase 3

increases expression

ISO

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:62,480,535...62,547,371
Ensembl chr X:62,480,535...62,547,371

G

prodynorphin

decreases expression

EXP

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

solute carrier family 2 member 4

multiple interactions

EXP

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 47 member 1

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

superoxide dismutase 1

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
decreases expression

EXP

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

secreted phosphoprotein 1

multiple interactions
increases expression

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

tumor necrosis factor

multiple interactions
increases expression

EXP

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

troponin I3, cardiac type

increases expression
multiple interactions

EXP

Tramadol results in increased expression of TNNI3 protein
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

vimentin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

venlafaxine hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
increases export

ISO

Venlafaxine Hydrochloride results in increased expression of ABCB1 mRNA
ABCB1 protein results in increased export of Venlafaxine Hydrochloride

PMID:14550684 PMID:17191263

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

angiotensin I converting enzyme

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ACE mRNA

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

acid phosphatase 5, tartrate resistant

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of ACP5 mRNA

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929

G

actin alpha 2, smooth muscle

multiple interactions

EXP

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

activin A receptor type 1C

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ACVR1C mRNA

NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:63,227,559...63,301,205

G

ADAM metallopeptidase domain 10

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ADAM10 mRNA

NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600

G

adhesion G protein-coupled receptor L1

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of ADGRL1 mRNA

NCBI chr19:41,107,162...41,148,752
Ensembl chr19:41,109,117...41,148,896

G

argonaute RISC catalytic component 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of AGO2 mRNA

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980

G

aryl hydrocarbon receptor

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

A-kinase anchoring protein 5

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of AKAP5 mRNA

NCBI chr 6:100,787,169...100,796,712
Ensembl chr 6:100,790,148...100,796,620

G

AKT serine/threonine kinase 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions

EXP

Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

activated leukocyte cell adhesion molecule

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ALCAM mRNA

NCBI chr11:61,804,932...62,005,250
Ensembl chr11:61,805,049...62,006,876

G

ankyrin repeat domain 55

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of ANKRD55 mRNA

NCBI chr 2:45,617,011...45,717,086
Ensembl chr 2:45,617,177...45,717,057

G

adaptor related protein complex 2 subunit beta 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of AP2B1 mRNA

NCBI chr10:68,596,925...68,702,547
Ensembl chr10:68,597,093...68,702,539

G

androgen receptor

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

activity-regulated cytoskeleton-associated protein

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ARC mRNA; Venlafaxine Hydrochloride results in increased expression of ARC protein

PMID:14580947 PMID:15087240 PMID:15838995

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

ARF GTPase 3

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of ARF3 mRNA

NCBI chr 7:131,765,039...131,792,075
Ensembl chr 7:131,750,672...131,770,123

G

Rho GTPase activating protein 10

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of ARHGAP10 mRNA

NCBI chr19:47,352,783...47,614,532
Ensembl chr19:47,352,276...47,614,531

G

Cdc42 guanine nucleotide exchange factor 9

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ARHGEF9 mRNA

NCBI chr X:63,929,168...64,087,267
Ensembl chr X:63,929,176...64,087,104

G

achaete-scute family bHLH transcription factor 1

decreases expression
increases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of ASCL1 mRNA
Venlafaxine Hydrochloride results in increased expression of ASCL1 mRNA

NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:23,790,360...23,798,231

G

ATPase plasma membrane Ca2+ transporting 3

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ATP2B3 mRNA

NCBI chr X:156,367,582...156,464,085
Ensembl chr X:156,367,852...156,438,153

G

ATRX, chromatin remodeler

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ATRX mRNA

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:74,916,548...75,062,880

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]

PMID:29852128 PMID:35104487

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

EXP

Venlafaxine Hydrochloride results in decreased expression of BCL2 mRNA
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]

PMID:25423262 PMID:29852128 PMID:35104487

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

beclin 1

multiple interactions

EXP

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

BMP/retinoic acid inducible neural specific 3

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of BRINP3 mRNA

NCBI chr13:60,964,127...61,397,044
Ensembl chr13:60,966,100...61,397,039

G

calcium voltage-gated channel auxiliary subunit beta 4

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CACNB4 mRNA

NCBI chr 3:57,315,900...57,578,271
Ensembl chr 3:57,315,900...57,578,220

G

calmodulin 3

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of CALM3 mRNA

NCBI chr 1:86,718,761...86,725,869
Ensembl chr 1:86,717,321...86,725,960

G

calcium/calmodulin-dependent protein kinase II alpha

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CAMK2A mRNA

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II beta

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase II gamma

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of CAMK2G mRNA

NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,553,294...3,612,310

G

caspase 3

multiple interactions

EXP

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]

PMID:29852128 PMID:35104487

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

EXP

Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased activity of CAT protein]

PMID:20305041 PMID:29852128

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

Cd47 molecule

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of CD47 mRNA

NCBI chr11:64,374,816...64,438,763
Ensembl chr11:64,377,926...64,438,272

G

cadherin 22

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of CDH22 mRNA

NCBI chr 3:174,264,869...174,389,940
Ensembl chr 3:174,264,869...174,390,142

G

CUGBP, Elav-like family member 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CELF2 mRNA

NCBI chr17:75,813,928...76,639,300
Ensembl chr17:75,813,704...76,636,362

G

chloride nucleotide-sensitive channel 1A

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of CLNS1A mRNA

NCBI chr 1:161,429,437...161,450,904
Ensembl chr 1:161,421,808...161,450,902

G

calsyntenin 2

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of CLSTN2 mRNA

NCBI chr 8:106,899,894...107,516,402
Ensembl chr 8:106,899,894...107,040,053

G

CCHC-type zinc finger, nucleic acid binding protein

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CNBP mRNA

NCBI chr 4:121,860,102...121,868,976
Ensembl chr 4:121,860,105...121,869,010

G

cannabinoid receptor 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CNR1 mRNA

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252

G

contactin 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CNTN2 mRNA

NCBI chr13:46,497,269...46,528,112
Ensembl chr13:46,499,396...46,528,027

G

cytochrome c oxidase copper chaperone COX17

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of COX17 mRNA

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

carboxypeptidase D

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CPD mRNA

NCBI chr10:62,121,681...62,185,638
Ensembl chr10:62,121,679...62,185,638

G

catenin beta 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CTNNB1 protein

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

CXXC finger protein 4

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of CXXC4 mRNA

NCBI chr 2:225,329,044...225,363,347

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions
decreases activity

ISO

Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]
Venlafaxine Hydrochloride results in decreased activity of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects methylation
decreases methylation

ISO

CYP2C19 gene polymorphism affects the methylation of Venlafaxine Hydrochloride
CYP2C19 protein results in decreased methylation of Venlafaxine Hydrochloride

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
affects response to substance
decreases methylation
increases metabolic processing
decreases activity

ISO

CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride; CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride
CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride
CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride
CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride
CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride
Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein

PMID:10774634 PMID:10877013 PMID:10933885 PMID:15632378 PMID:16044105 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

DAB adaptor protein 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of DAB2 mRNA

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:57,242,064...57,294,888

G

dimethylarginine dimethylaminohydrolase 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of DDAH1 mRNA

NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:237,327,766...237,460,626

G

distal membrane arm assembly component 1

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of DMAC1 mRNA

NCBI chr 5:94,288,900...94,290,053
Ensembl chr 5:94,280,654...94,290,119

G

DNA methyltransferase 3 alpha

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

dipeptidylpeptidase 4

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of DPP4 mRNA

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

endothelin receptor type B

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of EDNRB mRNA

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of ENPP1 mRNA

NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044

G

EPH receptor A5

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of EPHA5 mRNA

NCBI chr14:24,007,400...24,374,854
Ensembl chr14:24,008,122...24,374,848

G

formin-like 1

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of FMNL1 mRNA

NCBI chr10:88,615,290...88,643,411
Ensembl chr10:88,615,869...88,643,411

G

gamma-aminobutyric acid type A receptor subunit beta1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of GABRB1 mRNA

NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,434,352...36,902,893

G

gamma-aminobutyric acid type A receptor subunit beta 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of GABRB2 mRNA

NCBI chr10:27,438,127...27,657,680
Ensembl chr10:27,438,238...27,655,171

G

glutamate decarboxylase 2

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of GAD2 mRNA

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

growth arrest-specific 2

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of GAS2 mRNA

NCBI chr 1:110,587,952...110,721,572
Ensembl chr 1:110,717,312...110,718,541

G

growth arrest specific 6

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of GAS6 mRNA

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

guanine deaminase

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of GDA mRNA

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348

G

glial fibrillary acidic protein

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of GFAP mRNA

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glucagon-like peptide 1 receptor

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of GLP1R mRNA

NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654

G

G protein subunit alpha o1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of GNAO1 mRNA

NCBI chr19:11,040,788...11,198,437
Ensembl chr19:11,040,788...11,198,437

G

G protein subunit alpha q

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of GNAQ mRNA

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742

G

glutamate ionotropic receptor AMPA type subunit 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of GRIA1 mRNA

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of GRIA3 mRNA

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:125,103,782...125,369,679

G

glutamate ionotropic receptor NMDA type subunit 2A

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of GRIN2A mRNA

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of GRIN2B mRNA

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of HCN1 mRNA

NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:51,228,710...51,632,806

G

histone deacetylase 6

multiple interactions

EXP

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of HDAC6 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

hook microtubule-tethering protein 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of HOOK2 mRNA

NCBI chr19:40,056,732...40,075,027
Ensembl chr19:40,056,732...40,081,270

G

interleukin 1 receptor accessory protein-like 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of IL1RAPL1 mRNA

NCBI chr X:55,322,779...56,827,486
Ensembl chr X:55,328,964...56,826,613

G

potassium voltage-gated channel subfamily C member 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of KCNC2 mRNA

NCBI chr 7:49,586,274...49,770,212
Ensembl chr 7:49,586,136...49,770,212

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Venlafaxine Hydrochloride results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

ISO

Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104

G

potassium inwardly-rectifying channel, subfamily J, member 5

multiple interactions

ISO

Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]

NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:38,983,034...39,011,101

G

potassium inwardly-rectifying channel, subfamily J, member 6

multiple interactions

ISO

Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr11:47,531,312...47,778,348
Ensembl chr11:47,531,312...47,778,348

G

potassium two pore domain channel subfamily K member 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of KCNK1 mRNA

NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051

G

kinesin family member 1B

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of KIF1B mRNA

NCBI chr 5:164,890,778...165,025,848
Ensembl chr 5:164,894,763...165,008,841

G

kinesin family member 2B

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of KIF2B mRNA

NCBI chr10:76,891,199...76,893,418
Ensembl chr10:76,890,918...76,893,422

G

kinesin family member 5A

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of KIF5A mRNA

NCBI chr 7:64,937,210...64,974,339
Ensembl chr 7:64,934,740...64,978,272

G

KLF transcription factor 6

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of KLF6 mRNA

NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601

G

kelch-like family member 24

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

kallikrein related-peptidase 10

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of KLK10 mRNA

NCBI chr 1:103,371,638...103,375,918
Ensembl chr 1:103,371,638...103,375,918

G

LARGE xylosyl- and glucuronyltransferase 1

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of LARGE1 mRNA

NCBI chr19:11,609,004...12,057,174
Ensembl chr19:11,609,004...12,054,707

G

lipase G, endothelial type

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of LIPG mRNA

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:70,790,077...70,812,260

G

lectin, mannose-binding, 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of LMAN1 mRNA

NCBI chr18:61,778,971...61,800,960
Ensembl chr18:61,772,917...61,800,820

G

LIM domain 7

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of LMO7 mRNA

NCBI chr15:84,981,689...85,184,554
Ensembl chr15:84,981,735...85,184,551

G

lipoprotein lipase

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of MAGI2 mRNA

NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:15,278,518...16,762,199

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

EXP

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase 1

increases phosphorylation

EXP

Venlafaxine Hydrochloride results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

EXP

Venlafaxine Hydrochloride results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of MFNG mRNA

NCBI chr 7:112,191,288...112,209,129
Ensembl chr 7:112,161,071...112,209,129

G

matrix metallopeptidase 9

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

MAGUK p55 scaffold protein 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of MPP2 mRNA

NCBI chr10:87,511,638...87,544,710
Ensembl chr10:87,511,638...87,544,029

G

major vault protein

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of MVP mRNA

NCBI chr 1:191,025,259...191,052,866
Ensembl chr 1:191,025,268...191,052,873

G

myosin VA

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of MYO5A mRNA

NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:84,692,910...84,856,265

G

nuclear autoantigenic sperm protein

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of NASP mRNA

NCBI chr 5:135,294,599...135,319,992
Ensembl chr 5:135,294,032...135,319,591

G

neuronal growth regulator 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of NEGR1 mRNA

NCBI chr 2:248,283,164...249,015,538
Ensembl chr 2:248,283,353...249,018,410

G

neural EGFL like 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of NELL2 mRNA

NCBI chr 7:128,222,333...128,542,127
Ensembl chr 7:128,078,103...128,651,917

G

neuronal differentiation 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of NEUROD1 mRNA

NCBI chr 3:84,766,483...84,770,454
Ensembl chr 3:84,764,725...84,770,810

G

nuclear factor I X

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of NFIX mRNA

NCBI chr19:40,259,873...40,356,966
Ensembl chr19:40,260,084...40,353,092

G

neuronal pentraxin receptor

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of NPTXR mRNA

NCBI chr 7:113,217,046...113,235,122
Ensembl chr 7:113,217,050...113,235,156

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 3, group C, member 2

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of NR3C2 mRNA

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

NOP2/Sun RNA methyltransferase 2

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of NSUN2 mRNA

NCBI chr 1:35,490,583...35,514,839
Ensembl chr 1:35,490,583...35,514,306

G

neurotrophic receptor tyrosine kinase 2

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of NTRK2 mRNA

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

neurotrophic receptor tyrosine kinase 3

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of NTRK3 mRNA

NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004

G

PDGFA associated protein 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PDAP1 mRNA

NCBI chr12:14,584,414...14,594,641
Ensembl chr12:14,584,398...14,594,641

G

phosphodiesterase 4B

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of PDE4B mRNA

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

phosphodiesterase 4D

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of PDE4D mRNA

NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569

G

protein disulfide isomerase family A, member 3

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PDIA3 mRNA

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

3-phosphoinositide dependent protein kinase-1

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of PDPK1 mRNA

NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181

G

peroxisomal biogenesis factor 2

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of PEX2 mRNA

NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:97,948,443...97,981,092

G

progesterone receptor membrane component 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PGRMC1 mRNA

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

Pim-3 proto-oncogene, serine/threonine kinase

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PIM3 mRNA

NCBI chr 7:121,822,076...121,836,257
Ensembl chr 7:121,832,742...121,836,259

G

POU class 3 homeobox 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of POU3F2 mRNA

NCBI chr 5:40,874,631...40,880,539
Ensembl chr 5:40,874,601...40,881,010

G

protein phosphatase 1 catalytic subunit alpha

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of PPP1CA mRNA

NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:210,914,567...210,918,193

G

protein phosphatase 1, regulatory subunit 3A

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of PPP1R3A mRNA

NCBI chr 4:43,905,648...43,946,236
Ensembl chr 4:43,905,648...43,946,236

G

protein phosphatase 1, regulatory subunit 9B

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PPP1R9B mRNA

NCBI chr10:80,434,888...80,450,919
Ensembl chr10:80,434,900...80,450,919

G

protein phosphatase 3, regulatory subunit B, alpha

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PPP3R1 mRNA

NCBI chr14:95,758,333...95,808,015

G

proline-rich acidic protein 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PRAP1 mRNA

NCBI chr 1:204,312,723...204,316,519
Ensembl chr 1:204,312,723...204,316,517

G

peroxiredoxin 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of PRDX1 mRNA

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of PREX2 mRNA

NCBI chr 5:12,720,683...13,036,077
Ensembl chr 5:12,720,683...13,057,881

G

protein kinase C, epsilon

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of PRKCE mRNA

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase cGMP-dependent 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of PRKG2 mRNA

NCBI chr14:10,864,020...10,972,617
Ensembl chr14:10,864,186...10,972,614

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

EXP

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

prolactin

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

peptide YY

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of PYY mRNA

NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,561,353...87,562,206

G

RAB14, member RAS oncogene family

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of RAB14 mRNA

NCBI chr 3:38,899,430...38,920,572
Ensembl chr 3:38,901,400...38,912,273

G

RAB4B, member RAS oncogene family

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of RAB4B mRNA

NCBI chr 1:91,589,047...91,600,426
Ensembl chr 1:91,589,047...91,600,337

G

regulator of chromosome condensation 1

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of RCC1 mRNA

NCBI chr 5:149,810,037...149,828,475
Ensembl chr 5:149,810,689...149,828,523

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulating synaptic membrane exocytosis 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of RIMS1 mRNA

NCBI chr 9:32,193,352...32,692,998
Ensembl chr 9:32,193,352...32,692,772

G

ring finger protein 1

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of RING1 mRNA

NCBI chr20:4,832,013...4,835,516
Ensembl chr20:4,831,993...4,835,513

G

rabphilin 3A

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of RPH3A mRNA

NCBI chr12:41,203,004...41,279,536
Ensembl chr12:41,200,089...41,279,531

G

spalt-like transcription factor 1

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of SALL1 mRNA

NCBI chr19:34,179,316...34,196,278
Ensembl chr19:34,181,078...34,196,278

G

serpin family I member 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SERPINI1 mRNA

NCBI chr 2:162,645,209...162,731,737
Ensembl chr 2:162,645,350...162,731,740

G

small glutamine rich tetratricopeptide repeat co-chaperone beta

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SGTB mRNA

NCBI chr 2:36,966,840...37,003,318
Ensembl chr 2:36,966,838...37,003,311

G

SH3 and multiple ankyrin repeat domains 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SHANK2 mRNA

NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:208,598,772...209,018,736

G

signal-induced proliferation-associated 1 like 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SIPA1L1 mRNA

NCBI chr 6:107,570,569...107,849,613
Ensembl chr 6:107,737,392...107,848,160

G

solute carrier family 26 member 3

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SLC26A3 mRNA

NCBI chr 6:53,751,415...53,792,300
Ensembl chr 6:53,751,415...53,792,294

G

solute carrier family 2 member 4

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of SLC2A4 mRNA

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 4 member 4

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SLC4A4 mRNA

NCBI chr14:19,125,394...19,577,379
Ensembl chr14:19,129,264...19,577,435

G

solute carrier family 5 member 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SLC5A1 mRNA

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

solute carrier family 6 member 4

affects response to substance

ISO

SLC6A4 gene polymorphism affects the susceptibility to Venlafaxine Hydrochloride

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier family 6 member 6

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:125,752,372...125,826,032

G

superoxide dismutase 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

sialophorin

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SPN mRNA

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852

G

sequestosome 1

decreases expression
multiple interactions

EXP

Venlafaxine Hydrochloride results in decreased expression of SQSTM1 mRNA
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]

PMID:25423262 PMID:35104487

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

staufen double-stranded RNA binding protein 2

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of STAU2 mRNA

NCBI chr 5:7,623,528...7,868,206
Ensembl chr 5:7,624,019...7,868,204

G

serine threonine kinase 39

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of STK39 mRNA

NCBI chr 3:73,321,522...73,588,397
Ensembl chr 3:73,321,522...73,586,740

G

synaptic vesicle glycoprotein 2b

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of SV2B mRNA

NCBI chr 1:138,388,268...138,562,635
Ensembl chr 1:138,388,266...138,562,258

G

synapsin II

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of SYN2 mRNA

NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:149,851,520...150,019,650

G

synaptojanin 2

affects expression

EXP

Venlafaxine Hydrochloride affects the expression of SYNJ2 mRNA

NCBI chr 1:48,923,742...49,027,153
Ensembl chr 1:48,923,737...49,038,650

G

synaptophysin

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of SYP mRNA

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984

G

synaptotagmin 4

increases expression

ISO

Venlafaxine Hydrochloride results in increased expression of SYT4 mRNA

NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815

G

tachykinin receptor 3

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of TACR3 mRNA

NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:225,940,444...226,037,756

G

transcription factor 12

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of TCF12 mRNA

NCBI chr 8:81,371,201...81,682,337
Ensembl chr 8:81,373,321...81,679,922

G

transcription factor 4

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of TCF4 mRNA

NCBI chr18:65,216,840...65,563,186
Ensembl chr18:65,216,849...65,558,401

G

thrombomodulin

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of THBD mRNA

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582

G

tumor protein p53

multiple interactions

EXP

Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tripartite motif-containing 13

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of TRIM13 mRNA

NCBI chr15:39,909,587...39,948,719
Ensembl chr15:39,902,284...39,958,892

G

thyroid stimulating hormone receptor

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of TSHR mRNA

NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010

G

thioredoxin 2

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of TXN2 mRNA

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

ubiquitin conjugating enzyme E2 Q1

decreases expression

ISO

Venlafaxine Hydrochloride results in decreased expression of UBE2Q1 mRNA

NCBI chr 2:177,496,480...177,505,631
Ensembl chr 2:177,496,560...177,505,629

G

uncoupling protein 3

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of UCP3 mRNA

NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:164,227,882...164,241,210

G

unc-13 homolog B

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of UNC13B mRNA

NCBI chr 5:62,084,809...62,299,884
Ensembl chr 5:62,084,819...62,299,884

G

vesicle-associated membrane protein 1

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of VAMP1 mRNA

NCBI chr 4:159,698,894...159,705,582
Ensembl chr 4:159,698,629...159,713,608

G

valosin containing protein interacting protein 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of VCPIP1 mRNA

NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:14,316,918...14,347,778

G

voltage-dependent anion channel 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

vascular endothelial growth factor B

decreases expression

EXP

Venlafaxine Hydrochloride results in decreased expression of VEGFB mRNA

NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152

G

WD repeat and FYVE domain containing 1

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of WDFY1 mRNA

NCBI chr 9:88,459,613...88,541,215
Ensembl chr 9:88,489,227...88,541,186

G

zinc finger protein 24

increases expression

EXP

Venlafaxine Hydrochloride results in increased expression of ZFP24 mRNA

NCBI chr18:15,573,031...15,583,432
Ensembl chr18:15,574,762...15,582,290

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20841
chemical entity	20839
molecular entity	20838
polyatomic entity	20782
heteroatomic molecular entity	20718
hydroxides	20211
organic hydroxy compound	19751
alcohol	16108
cyclohexanols	235
(1R,3R)-5-(hydroxymethyl)cyclohexane-1,2,3-triol	0
(1S,2S,5S)-2-(4-glutaridylbenzyl)-5-phenylcyclohexan-1-ol	0
(4E, 8E)-N-2-hydroxyhexadecanoyl-1-O-beta-glucopyranosyl-9-methyl-C18-sphinga-4,8-dienine	0
1-Cyclopropyl-4-methyl-1,3-cyclohexanediol	0
2,4-dimethyl-Cyclohexanol	0
2-Deoxystreptamine phosphate	0
2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol +	1
2-aminocyclohexan-1-ol(1+)	0
2-hydroxy-2-phenylcyclohexanecarboxylic acid +	0
2-hydroxy-3,6-diphenylcyclohexyl acetate	0
3,3,5-trimethylcyclohexanol +	0
3,4-Dimethylcyclohexanol	0
3,5-Dimethylcyclohexanol	0
3,6-Diphenylcyclohexan-1,2-diol	0
3-Methylcyclohexanol	0
4-[1-Cyclohexyl-2-(2-piperidinyl)ethyl]cyclohexanol	0
5-epi-Valiolol 7-phosphate	0
Ampelomin C	0
Ampelomin D	0
Ampelomin E	0
Ampelomin F	0
Arthpyrone E	0
Brasilamide F	0
Brasilamide I	0
Brasilamide J	0
Citrantifidiol	0
D-4-O-Methyl-myo-inositol	0
Dambonitol	0
Dendrodochol B	0
Dendrodochol C	0
Deoxyvalidamine	0
Dothideomycetone A	0
GSK046	0
Iso-enacyloxin IIa	0
L-Quebrachitol	0
Mytilitol	0
N,N-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine-glucuronide	0
N-desmethylvenlafaxine	0
O-Methyl-scyllo-inositol	0
O-desmethylvenlafaxine	0
Phomaketide A	0
Phomaketide B	0
Polisin C	0
Rengyol	0
SB-239063	24
Speciosin H	0
Speciosin I	0
Speciosin J	0
Speciosin Q	0
Speciosin R	0
Speciosin S	0
Stagonosporyne A	0
Stagonosporyne B	0
Stagonosporyne C	0
Waikialide B	0
beta-2,3,4,5,6-Pentachlorocyclohexanol	0
beta-2,3,5,6-Tetrachloro-1,4-cyclohexanediol	0
cethexonium	0
ciramadol	0
cis-5-caffeoyl-quinic acid	0
cyclohexanol +	38
grasshopper ketone	0
rociverine	0
trans-4-Phenyl-4-piperidinocyclohexanol	0
venlafaxine +	182
Path 2
Term	Annotations
CHEBI ontology	20841
subatomic particle	20839
composite particle	20839
hadron	20839
baryon	20839
nucleon	20839
atomic nucleus	20839
atom	20839
main group element atom	20762
p-block element atom	20786
p-block molecular entity	20762
chalcogen molecular entity	20473
oxygen molecular entity	20439
hydroxides	20211
organic hydroxy compound	19751
alcohol	16108
cyclohexanols	235
(1R,3R)-5-(hydroxymethyl)cyclohexane-1,2,3-triol	0
(1S,2S,5S)-2-(4-glutaridylbenzyl)-5-phenylcyclohexan-1-ol	0
(4E, 8E)-N-2-hydroxyhexadecanoyl-1-O-beta-glucopyranosyl-9-methyl-C18-sphinga-4,8-dienine	0
1-Cyclopropyl-4-methyl-1,3-cyclohexanediol	0
2,4-dimethyl-Cyclohexanol	0
2-Deoxystreptamine phosphate	0
2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol +	1
2-aminocyclohexan-1-ol(1+)	0
2-hydroxy-2-phenylcyclohexanecarboxylic acid +	0
2-hydroxy-3,6-diphenylcyclohexyl acetate	0
3,3,5-trimethylcyclohexanol +	0
3,4-Dimethylcyclohexanol	0
3,5-Dimethylcyclohexanol	0
3,6-Diphenylcyclohexan-1,2-diol	0
3-Methylcyclohexanol	0
4-[1-Cyclohexyl-2-(2-piperidinyl)ethyl]cyclohexanol	0
5-epi-Valiolol 7-phosphate	0
Ampelomin C	0
Ampelomin D	0
Ampelomin E	0
Ampelomin F	0
Arthpyrone E	0
Brasilamide F	0
Brasilamide I	0
Brasilamide J	0
Citrantifidiol	0
D-4-O-Methyl-myo-inositol	0
Dambonitol	0
Dendrodochol B	0
Dendrodochol C	0
Deoxyvalidamine	0
Dothideomycetone A	0
GSK046	0
Iso-enacyloxin IIa	0
L-Quebrachitol	0
Mytilitol	0
N,N-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine-glucuronide	0
N-desmethylvenlafaxine	0
O-Methyl-scyllo-inositol	0
O-desmethylvenlafaxine	0
Phomaketide A	0
Phomaketide B	0
Polisin C	0
Rengyol	0
SB-239063	24
Speciosin H	0
Speciosin I	0
Speciosin J	0
Speciosin Q	0
Speciosin R	0
Speciosin S	0
Stagonosporyne A	0
Stagonosporyne B	0
Stagonosporyne C	0
Waikialide B	0
beta-2,3,4,5,6-Pentachlorocyclohexanol	0
beta-2,3,5,6-Tetrachloro-1,4-cyclohexanediol	0
cethexonium	0
ciramadol	0
cis-5-caffeoyl-quinic acid	0
cyclohexanol +	38
grasshopper ketone	0
rociverine	0
trans-4-Phenyl-4-piperidinocyclohexanol	0
venlafaxine +	182

paths to the root