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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclodextrin
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Accession:CHEBI:23456 term browser browse the term
Definition:A macrocycle composed of five or more D-glucopyranose units bonded via (1->4)-linkages.
Synonyms:related_synonym: cyclodextrins
 xref: Wikipedia:Cyclodextrin


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beta-cyclodextrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO betadex inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO betadex inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO betadex inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein] CTD PMID:11035063 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO betadex inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO betadex inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:11035063 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Tfeb transcription factor EB affects localization ISO betadex affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO betadex inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] CTD PMID:11035063 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
methyl beta-cyclodextrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases transport EXP methyl-beta-cyclodextrin results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Cholesterol affects the localization of APOE protein] CTD PMID:21169230 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Bacterial Toxins results in increased phosphorylation of ATF2 protein] CTD PMID:17030583 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [BDNF protein results in decreased activity of HU 211] CTD PMID:20554863 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp1 caspase 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]
methyl-beta-cyclodextrin inhibits the reaction [1-nitropyrene results in increased activity of CASP3 protein]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol results in increased activity of CASP3 protein]
CTD PMID:21362627 PMID:21872649 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein] CTD PMID:21362627 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cav1 caveolin 1 multiple interactions EXP
ISO
methyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides results in increased expression of CAV1 protein modified form]
methyl-beta-cyclodextrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] affects the localization of CAV1 protein]
CTD PMID:20060843 PMID:26357463 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Cocaine results in increased expression of CCL2 protein] CTD PMID:20354174 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]] CTD PMID:21821728 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [EDN1 protein affects the localization of CD38 protein] CTD PMID:23940720 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of CYBB protein] CTD PMID:20036696 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased expression of DDIT3 mRNA] CTD PMID:30502353 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Des desmin multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [EDN1 protein affects the localization of CD38 protein] CTD PMID:23940720 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egf epidermal growth factor multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]] CTD PMID:16971554 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO methyl-beta-cyclodextrin inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; methyl-beta-cyclodextrin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
methyl-beta-cyclodextrin results in decreased expression of HMOX1 protein
CTD PMID:24140437 PMID:24423726 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA] CTD PMID:30502353 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
decreases expression
ISO methyl-beta-cyclodextrin inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]; methyl-beta-cyclodextrin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]
methyl-beta-cyclodextrin results in decreased expression of HSPB1 protein
CTD PMID:21457723 PMID:24140437 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] CTD PMID:19632255 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] affects the localization of CAV1 protein] CTD PMID:20060843 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein] CTD PMID:19632255 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Lat linker for activation of T cells multiple interactions EXP methyl-beta-cyclodextrin inhibits the reaction [dinitrophenyl-bovine serum albumin affects the phosphorylation of LAT protein] CTD PMID:19794068 NCBI chr 1:197,765,644...197,770,669
Ensembl chr 1:197,765,644...197,770,669
JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions ISO methyl-beta-cyclodextrin promotes the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein] CTD PMID:23001822 NCBI chr12:25,114,099...25,128,381
Ensembl chr12:25,119,355...25,125,749
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]] CTD PMID:21821728 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein] CTD PMID:15930183 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein] CTD PMID:15930183 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir21 microRNA 21 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] CTD PMID:25969534 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 affects localization
multiple interactions
EXP methyl-beta-cyclodextrin affects the localization of MS4A2 protein
methyl-beta-cyclodextrin inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of and affects the localization of MS4A2 protein]
CTD PMID:19794068 NCBI chr 1:227,957,363...227,965,312
Ensembl chr 1:227,957,302...227,965,386
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of NCF1 protein] CTD PMID:20036696 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:21362627 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]] CTD PMID:16971554 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein] CTD PMID:21362627 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Bacterial Toxins affects the localization of PTPRZ1 protein] CTD PMID:17030583 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein affects the localization of RELA protein]] CTD PMID:23274767 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [pentabromophenol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]] CTD PMID:28230093 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Cocaine results in increased localization of SIGMAR1 protein] CTD PMID:20354174 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Copper affects the localization of SLC31A1 protein] CTD PMID:12501239 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc39a4 solute carrier family 39 member 4 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein] CTD PMID:17202136 NCBI chr 7:117,675,718...117,682,586
Ensembl chr 7:117,675,720...117,680,004
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [pentabromophenol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]] CTD PMID:28230093 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of SRC protein] CTD PMID:19632255 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a multiple interactions ISO [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] promotes the reaction [SV2A protein binds to Botulinum Toxins, Type A] CTD PMID:28645175 NCBI chr 2:198,321,100...198,336,889
Ensembl chr 2:198,321,142...198,336,913
JBrowse link
G Tf transferrin affects localization ISO methyl-beta-cyclodextrin affects the localization of TF protein CTD PMID:12501239 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [pentabromophenol inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; methyl-beta-cyclodextrin inhibits the reaction [pentabromophenol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]] CTD PMID:28230093 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein] CTD PMID:31381904 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein affects the localization of RELA protein]]; [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]] CTD PMID:23274767 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] CTD PMID:19632255 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions ISO methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA] CTD PMID:25969534 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      molecular entity 19770
        polyatomic entity 19688
          molecule 19527
            cyclic compound 19358
              macrocycle 2324
                cyclodextrin 55
                  alpha-cyclodextrin 0
                  beta-cyclodextrin + 55
                  gamma-cyclodextrin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            heteroorganic entity 19199
                              organochalcogen compound 18946
                                organooxygen compound 18873
                                  carbohydrates and carbohydrate derivatives 12285
                                    carbohydrate 12285
                                      polysaccharide 3063
                                        homopolysaccharide 1374
                                          glucan 1355
                                            dextrins 56
                                              maltodextrin 56
                                                cyclomaltodextrin 55
                                                  cyclodextrin 55
                                                    alpha-cyclodextrin 0
                                                    beta-cyclodextrin + 55
                                                    gamma-cyclodextrin + 0
paths to the root