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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclitol
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Accession:CHEBI:23451 term browser browse the term
Definition:A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom.
Synonyms:exact_synonym: cyclitols


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gentamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Gentamicins results in increased expression of BAX protein modified form CTD PMID:16569831 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G CASP3 caspase 3 increases expression EXP Gentamicins results in increased expression of CASP3 mRNA CTD PMID:28372472 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G EXOC6 exocyst complex component 6 increases expression EXP Gentamicins results in increased expression of EXOC6 mRNA CTD PMID:28372472 NCBI chr14:104,326,943...104,549,638
Ensembl chr14:104,326,827...104,549,636 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 increases expression EXP Gentamicins results in increased expression of HAVCR1 mRNA CTD PMID:28372472 NCBI chr16:66,162,318...66,208,868 JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression EXP Gentamicins results in increased expression of ICAM1 mRNA CTD PMID:28372472 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
gentamycin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E decreases uptake
multiple interactions		 EXP APOE protein results in decreased uptake of gentamicin C
APOE protein inhibits the reaction [gentamicin C results in decreased expression of and results in decreased activity of SLC5A1 protein]; APOE protein inhibits the reaction [gentamicin C results in decreased expression of SLC5A1 mRNA]		 CTD PMID:15777622 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G SLC5A1 solute carrier family 5 member 1 decreases expression
multiple interactions		 EXP gentamicin C results in decreased expression of SLC5A1 mRNA; gentamicin C results in decreased expression of SLC5A1 protein
[gentamicin C results in decreased expression of and results in decreased activity of SLC5A1 protein] which results in decreased uptake of Aminoglycosides; APOE protein inhibits the reaction [gentamicin C results in decreased expression of and results in decreased activity of SLC5A1 protein]; APOE protein inhibits the reaction [gentamicin C results in decreased expression of SLC5A1 mRNA]; gentamicin C results in decreased expression of and results in decreased activity of SLC5A1 protein		 CTD PMID:12927799 PMID:15777622 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841 		JBrowse link
neomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC5A1 solute carrier family 5 member 1 decreases expression EXP Neomycin results in decreased expression of SLC5A1 mRNA; Neomycin results in decreased expression of SLC5A1 protein CTD PMID:12927799 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    chemical entity 5080
      molecular entity 5051
        polyatomic entity 5032
          heteroatomic molecular entity 5001
            hydroxides 4835
              organic hydroxy compound 4767
                polyol 4329
                  cyclitol 7
                    (+)-quercitol 0
                    (-)-Pericosine Do 0
                    (-)-Quebrachitol 0
                    (-)-viburnitol 0
                    1-Keto-D-chiro-inositol 0
                    2-(2,6-dihydroxy-3,4-dimethoxycyclohexylidene)acetonitrile 0
                    2-epi-5-epi-valiolone + 0
                    2-epi-5-epi-valiolone 7-phosphate 0
                    2-epi-valiolone 0
                    3-amino-2-carboxamine-4(S),6(S)-dihydroxy-cyclohex-2-en-1-one 0
                    5-[(E)-3-Hydroxy-3-methylbut-1-enyl]-2-methylcyclohex-5-ene-1,2,4-triol 0
                    5-epi-valiolone + 0
                    5-epi-valiolone 7-phosphate 0
                    Acremin F 0
                    Acremine F 0
                    Aspergone N 0
                    Aspergone O 0
                    Asperunguisin E 0
                    Biscognienyne A 0
                    Biscognienyne C 0
                    Bluensidine 6-phosphate 0
                    Chlovalicin 0
                    Drim-8(12)-en-6beta,7alpha, 9alpha,11-tetraol 0
                    Epoxypholamin C, (rel)- 0
                    Epoxypholamin D, (rel)- 0
                    Gabosine B 0
                    Gabosine F 0
                    Gabosine K 0
                    Gabosine O 0
                    Kirkamide 0
                    Lentinoid B 0
                    Pallidopenilline F 0
                    Phomentrioloxin 0
                    Rancinamycin III 0
                    Stagonosporyne G 0
                    Streptol 0
                    amino cyclitol + 0
                    amino cyclitol glycoside + 7
                    conduritol + 0
                    conduritol epoxide + 0
                    cyclitol ester + 0
                    cyclitol ether + 0
                    cyclitol nicotinate + 0
                    cyclitol phosphate + 0
                    demethylgadusol(1-) 0
                    gadusol(1-) 0
                    inositol + 0
                    methyl myo-inositols + 0
                    validone + 0
                    valiolone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      p-block molecular entity 5010
                        chalcogen molecular entity 4915
                          oxygen molecular entity 4883
                            hydroxides 4835
                              organic hydroxy compound 4767
                                polyol 4329
                                  cyclitol 7
                                    (+)-quercitol 0
                                    (-)-Pericosine Do 0
                                    (-)-Quebrachitol 0
                                    (-)-viburnitol 0
                                    1-Keto-D-chiro-inositol 0
                                    2-(2,6-dihydroxy-3,4-dimethoxycyclohexylidene)acetonitrile 0
                                    2-epi-5-epi-valiolone + 0
                                    2-epi-5-epi-valiolone 7-phosphate 0
                                    2-epi-valiolone 0
                                    3-amino-2-carboxamine-4(S),6(S)-dihydroxy-cyclohex-2-en-1-one 0
                                    5-[(E)-3-Hydroxy-3-methylbut-1-enyl]-2-methylcyclohex-5-ene-1,2,4-triol 0
                                    5-epi-valiolone + 0
                                    5-epi-valiolone 7-phosphate 0
                                    Acremin F 0
                                    Acremine F 0
                                    Aspergone N 0
                                    Aspergone O 0
                                    Asperunguisin E 0
                                    Biscognienyne A 0
                                    Biscognienyne C 0
                                    Bluensidine 6-phosphate 0
                                    Chlovalicin 0
                                    Drim-8(12)-en-6beta,7alpha, 9alpha,11-tetraol 0
                                    Epoxypholamin C, (rel)- 0
                                    Epoxypholamin D, (rel)- 0
                                    Gabosine B 0
                                    Gabosine F 0
                                    Gabosine K 0
                                    Gabosine O 0
                                    Kirkamide 0
                                    Lentinoid B 0
                                    Pallidopenilline F 0
                                    Phomentrioloxin 0
                                    Rancinamycin III 0
                                    Stagonosporyne G 0
                                    Streptol 0
                                    amino cyclitol + 0
                                    amino cyclitol glycoside + 7
                                    conduritol + 0
                                    conduritol epoxide + 0
                                    cyclitol ester + 0
                                    cyclitol ether + 0
                                    cyclitol nicotinate + 0
                                    cyclitol phosphate + 0
                                    demethylgadusol(1-) 0
                                    gadusol(1-) 0
                                    inositol + 0
                                    methyl myo-inositols + 0
                                    validone + 0
                                    valiolone + 0
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