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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyanopyridine
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Accession:CHEBI:23438 term browser browse the term
Definition:Any pyridine carrying at least one cyano substituent.
Synonyms:related_synonym: Formula=C6H4N2;   cyanopyridines


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BAY 60-6583 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor multiple interactions EXP BAY 60-6583 binds to and results in increased activity of ADORA2B protein CTD PMID:19749167 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
increases expression
ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [[BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein]; 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of CXCL12 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of CXCL12 protein CTD PMID:27590504 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [BAY 60-6583 results in increased expression of FGF2 protein]; [BAY 60-6583 co-treated with cobaltous chloride] results in increased expression of FGF2 protein CTD PMID:27590504 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK1 protein CTD PMID:27590504 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO BAY 60-6583 results in increased phosphorylation of MAPK3 protein CTD PMID:27590504 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
CHIR 99021 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Chir 99021 results in decreased expression of ACADVL mRNA CTD PMID:29883716 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
JBrowse link
G Acan aggrecan decreases expression ISO Chir 99021 results in decreased expression of ACAN mRNA CTD PMID:32220932 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Afp alpha-fetoprotein increases expression ISO Chir 99021 results in increased expression of AFP mRNA CTD PMID:31711903 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Chir 99021 binds to and results in increased activity of AHR protein; Chir 99021 inhibits the reaction [AHR protein results in decreased expression of VIM protein] CTD PMID:26259606 PMID:27752740 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of ALDH1A2 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Apoa1 apolipoprotein A1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of APOA1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of APOA1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of APOA1 mRNA]
CTD PMID:31711903 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Chir 99021 results in increased expression of BGLAP mRNA CTD PMID:32220932 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Chir 99021 affects the reaction [NAMPT protein affects the expression of CCND1 protein] CTD PMID:32005247 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdx1 caudal type homeo box 1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of CDX1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of CDX1 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of CDX1 mRNA]]
CTD PMID:31711903 NCBI chr18:54,472,448...54,499,799
Ensembl chr18:54,473,444...54,490,814
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
affects localization
multiple interactions
ISO Chir 99021 results in increased expression of CTNNB1 protein
Chir 99021 affects the localization of CTNNB1 protein
Chir 99021 affects the reaction [NAMPT protein affects the expression of CTNNB1 protein]; Chir 99021 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]
CTD PMID:26259606 PMID:31715269 PMID:32005247 PMID:32220932 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Chir 99021 results in increased expression of CYP1A2 mRNA CTD PMID:26259606 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Chir 99021 results in increased expression of and results in increased activity of CYP2E1 protein
Chir 99021 results in increased expression of CYP2E1 mRNA
CTD PMID:26259606 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Chir 99021 results in increased expression of CYP3A4 mRNA CTD PMID:26259606 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon multiple interactions ISO Chir 99021 promotes the reaction [GSK3B protein affects the phosphorylation of EIF2B5 protein] CTD PMID:29883716 NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419
JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Chir 99021 results in increased expression of ESRRA mRNA CTD PMID:29883716 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA1 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA1 mRNA] CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G Fbxo32 F-box protein 32 decreases expression
multiple interactions
ISO Chir 99021 results in decreased expression of FBXO32 mRNA
Chir 99021 inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]
CTD PMID:21832246 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fgf8 fibroblast growth factor 8 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of FGF8 mRNA] CTD PMID:31711903 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Foxa1 forkhead box A1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of FOXA1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of FOXA1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of FOXA1 mRNA]
CTD PMID:31711903 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxc2 forkhead box C2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXC2 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXC2 mRNA] CTD PMID:31711903 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737
JBrowse link
G Gata6 GATA binding protein 6 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of GATA6 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of GATA6 mRNA] CTD PMID:31711903 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects phosphorylation
multiple interactions
decreases activity
ISO Chir 99021 affects the phosphorylation of GSK3B protein
Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]; Chir 99021 promotes the reaction [GSK3B protein affects the expression of PPARGC1A protein]; Chir 99021 promotes the reaction [GSK3B protein affects the phosphorylation of EIF2B5 protein]
Chir 99021 results in decreased activity of GSK3B protein
CTD PMID:27752740 PMID:29883716 PMID:30165626 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hes5 hes family bHLH transcription factor 5 multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of HES5 mRNA CTD PMID:20865013 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001
JBrowse link
G Hes7 hes family bHLH transcription factor 7 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of HES7 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HES7 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HES7 mRNA]]
CTD PMID:31711903 NCBI chr10:53,824,124...53,828,350
Ensembl chr10:53,825,574...53,828,097
JBrowse link
G Hoxb1 homeo box B1 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB1 mRNA CTD PMID:31711903 NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836
JBrowse link
G Hoxb3 homeo box B3 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB3 mRNA CTD PMID:31711903 NCBI chr10:81,258,739...81,314,134
Ensembl chr10:81,299,357...81,313,107
JBrowse link
G Hoxb5 homeo box B5 multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the reaction [Chir 99021 results in increased expression of HOXB5 mRNA]; Tretinoin affects the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the reaction [Chir 99021 results in increased expression of HOXB5 mRNA]] CTD PMID:31711903 NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580
JBrowse link
G Hoxb7 homeo box B7 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of HOXB7 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HOXB7 mRNA]
CTD PMID:31711903 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
JBrowse link
G Hoxb9 homeo box B9 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Ihh Indian hedgehog signaling molecule multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of IHH mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of IHH mRNA] CTD PMID:31711903 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of LAMP1 protein] CTD PMID:30165626 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 increases expression ISO Chir 99021 results in increased expression of LGR5 mRNA CTD PMID:26259606 NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MAP1LC3A protein] CTD PMID:30165626 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Meox1 mesenchyme homeobox 1 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEOX1 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEOX1 mRNA] CTD PMID:31711903 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MESP2 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MESP2 mRNA] CTD PMID:31711903 NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198
JBrowse link
G Mpp1 membrane palmitoylated protein 1 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of MPP1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of MPP1 mRNA] CTD PMID:31711903
G Msgn1 mesogenin 1 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of MSGN1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of MSGN1 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of MSGN1 mRNA]]
CTD PMID:31711903 NCBI chr 6:33,912,787...33,913,427
Ensembl chr 6:33,912,787...33,913,427
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Chir 99021 results in increased expression of MYC protein CTD PMID:25897075 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Chir 99021 affects the reaction [NAMPT protein affects the expression of CCND1 protein]; Chir 99021 affects the reaction [NAMPT protein affects the expression of CTNNB1 protein] CTD PMID:32005247 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Chir 99021 results in decreased expression of NANOG mRNA CTD PMID:31711903 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nes nestin multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of NES mRNA CTD PMID:20865013 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Neurog2 neurogenin 2 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,641...216,095,276
Ensembl chr 2:216,093,363...216,094,154
JBrowse link
G Nodal nodal growth differentiation factor multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of NODAL mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of NODAL mRNA] CTD PMID:31711903 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Chir 99021 binds to and results in increased activity of NR1I2 protein CTD PMID:26259606 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression ISO Chir 99021 results in decreased expression of NRF1 mRNA CTD PMID:29883716 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149
JBrowse link
G Pax3 paired box 3 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of PAX3 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Pax6 paired box 6 multiple interactions
increases expression
ISO [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] promotes the reaction [Chir 99021 results in increased expression of PAX6 mRNA] CTD PMID:31711903 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 increases expression ISO Chir 99021 results in increased expression of PERM1 mRNA CTD PMID:29883716 NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Chir 99021 results in decreased expression of POU5F1 mRNA CTD PMID:31711903 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Chir 99021 results in decreased expression of PPARA mRNA CTD PMID:29883716 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Chir 99021 results in decreased expression of PPARD mRNA CTD PMID:29883716 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO Chir 99021 promotes the reaction [GSK3B protein affects the expression of PPARGC1A protein]
Chir 99021 results in increased expression of PPARGC1A mRNA; Chir 99021 results in increased expression of PPARGC1A protein
CTD PMID:29883716 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 increases expression ISO Chir 99021 results in increased expression of RICTOR protein CTD PMID:25897075 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Chir 99021 results in increased expression of RUNX2 mRNA CTD PMID:32220932 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sox17 SRY-box transcription factor 17 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of SOX17 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of SOX17 mRNA] CTD PMID:31711903 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression
multiple interactions
ISO Chir 99021 results in decreased expression of SOX2 mRNA
[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in decreased expression of SOX2 mRNA]
CTD PMID:31711903 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Chir 99021 results in decreased expression of SOX9 mRNA CTD PMID:32220932 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp7 Sp7 transcription factor increases expression
affects localization
ISO Chir 99021 results in increased expression of SP7 mRNA
Chir 99021 affects the localization of SP7 protein
CTD PMID:32220932 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein] CTD PMID:30165626 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Syp synaptophysin multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of SYP mRNA CTD PMID:20865013 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tbx1 T-box transcription factor 1 multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of BRACHYURY mRNA]; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of BRACHYURY mRNA CTD PMID:31711903 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380
JBrowse link
G Tbx6 T-box transcription factor 6 increases expression
multiple interactions
ISO Chir 99021 results in increased expression of TBX6 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of TBX6 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of TBX6 mRNA]]
CTD PMID:31711903 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593
JBrowse link
G Tcf15 transcription factor 15 multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of TCF15 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO Chir 99021 affects the reaction [1-Methyl-4-phenylpyridinium affects the localization of TFEB protein]; Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]; Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [YWHAQ protein binds to TFEB protein]] CTD PMID:30165626 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of TUBB3 mRNA CTD PMID:20865013 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Uncx UNC homeobox multiple interactions ISO [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNCX mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNCX mRNA] CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
JBrowse link
G Vim vimentin multiple interactions ISO Chir 99021 inhibits the reaction [AHR protein results in decreased expression of VIM protein] CTD PMID:27752740 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt3a Wnt family member 3A increases expression
multiple interactions
ISO Chir 99021 results in increased expression of WNT3A mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of WNT3A mRNA]; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of WNT3A mRNA
CTD PMID:31711903 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Wnt5a Wnt family member 5A increases expression
multiple interactions
ISO Chir 99021 results in increased expression of WNT5A mRNA
[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of WNT5A mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT5A mRNA
CTD PMID:31711903 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [YWHAQ protein binds to TFEB protein]] CTD PMID:30165626 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      group 19741
        pseudohalo group 3490
          cyano group 3490
            nitrile 3490
              cyanopyridine 76
                (R)-6-(4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile 0
                2-cyanopyridine 0
                4-cyanopyridine 0
                BAY 60-6583 5
                CHIR 99021 71
                ivosidenib 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteromonocyclic compound 17084
                                    pyridines 9100
                                      cyanopyridine 76
                                        (R)-6-(4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl)nicotinonitrile 0
                                        2-cyanopyridine 0
                                        4-cyanopyridine 0
                                        BAY 60-6583 5
                                        CHIR 99021 71
                                        ivosidenib 0
paths to the root