The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A pyranothiazole that is (3aR,7aR)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole substituted by an ethylamino, hydroxymethyl, hydroxy, and hydroxy groups at positions 2, 5R, 6S, and 7R. It is a potent and selective inhibitor of O-GlcNAcase (Ki = 21 nM).
thiamet G results in increased O-linked glycosylation of CHD4 protein [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; Butyric Acid inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; thiamet G promotes the reaction [CHD4 protein binds to HBG2 promoter]
thiamet G inhibits the reaction [Dextran Sulfate results in decreased expression of OGA protein]; thiamet G results in decreased activity of and results in increased expression of OGA protein thiamet G promotes the reaction [OGA protein binds to HBG2 promoter]
thiamet G results in decreased expression of OGT protein thiamet G inhibits the reaction [Dextran Sulfate results in increased expression of OGT protein] thiamet G promotes the reaction [OGT protein binds to HBG2 promoter]
thiamet G promotes the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; thiamet G promotes the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]
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