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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:citraconoyl group
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Accession:CHEBI:23315 term browser browse the term
Synonyms:exact_synonym: (2Z)-2-methylbut-2-enedioyl
 related_synonym: 2-methylmaleyl;   Formula=C5H4O2;   SMILES=C(=C(\\C)/C(*)=O)(\\[H])/C(=O)*;   citraconoyl


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Arecaidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO arecaidine results in increased expression of TIMP1 mRNA; arecaidine results in increased expression of TIMP1 protein CTD PMID:16311067 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
Cassine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 multiple interactions ISO [cassine co-treated with spectaline] results in decreased expression of CCND1 mRNA CTD PMID:26616281 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [cassine co-treated with spectaline] results in decreased phosphorylation of MAPK1 protein CTD PMID:26616281 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [cassine co-treated with spectaline] results in decreased phosphorylation of MAPK3 protein CTD PMID:26616281 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
N'-Nitrosoanabasine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein affects the metabolism of and results in increased activity of N'-nitrosoanabasine CTD PMID:11774366 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO N'-nitrosoanabasine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]
N'-nitrosoanabasine results in decreased activity of CYP2A13 protein		 CTD PMID:27567546 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the metabolism of and results in increased activity of N'-nitrosoanabasine CTD PMID:11774366 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of N'-nitrosoanabasine CTD PMID:18238858 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
N-Nitrosoguvacoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases activity ISO CYP2A13 protein results in increased activity of N-nitrosoguvacoline CTD PMID:15725615 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
Nicotine imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases chemical synthesis ISO CYP2B6 protein results in increased chemical synthesis of nicotine imine CTD PMID:30906561 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
Pancratistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO pancratistatin results in increased activity of CASP3 protein CTD PMID:15726366 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
Voacamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [voacamine co-treated with Paclitaxel] results in increased cleavage of PARP1 protein CTD PMID:34856211 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions		 ISO voacamine affects the localization of RELA protein
Paclitaxel promotes the reaction [voacamine affects the localization of RELA protein]		 CTD PMID:34856211 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      group 19788
        organic group 18944
          acyl group 17699
            carboacyl group 17699
              divalent carboacyl group 12
                citraconoyl group 12
                  (+)-dihydropinidine 0
                  (-)-Sedamine 0
                  (-)-Solenopsin A 0
                  (-)-epidihydropinidine 0
                  (-)-pinidinone 0
                  (2S,4R,6R)-2-methyl-6-nonylpiperidin-4-ol 0
                  (E)-2-methyl-4-((3aS)-1-methyl-2,3,8,8a-tetrahydropyrrolo[2,3-b]indol-3a(1H)-yl)but-2-en-1-ol 0
                  2-(Pyridin-3-yl)piperidine-1-carbaldehyde 0
                  2-pentyl-Piperidine 0
                  6,6'-(1,2,3,5,8,8a-Hexahydroindolizine-6,8-diyldi-10,1-decanediyl)bis(2-methyl-3-piperidinol) 0
                  Anapheline 0
                  Anatalline 0
                  Aquifoliunine EII 0
                  Aquifoliunine EIII 0
                  Arecaidine 1
                  Brunsvigine 0
                  Cassine 3
                  Echinatine 0
                  Elaeokanine C 0
                  Epivoacorine 0
                  Gabunine 0
                  Heliosupine N-oxide 0
                  Heliotridine viridiflorate N-oxide 0
                  Heliotrine n-oxide 0
                  Homoarecoline 0
                  Hydroxysenkirkine 0
                  Isatidine 0
                  Juliflorine 0
                  LSM-2853 0
                  Lobelanidine 0
                  Lyconnotine 0
                  N'-Nitrosoanabasine 4
                  N,N,N-Trimethylserotonin 0
                  N-Methylpelletierine 0
                  N-Nitrosoguvacine 0
                  N-Nitrosoguvacoline 1
                  Nangustine 0
                  Neurine 0
                  Nicotine imine 1
                  Nupharamine 0
                  O7-Angeloylretronecine 0
                  Pancratistatin 1
                  Pelletierine 0
                  Pilosine 0
                  Prosafrinine 0
                  Pseudoconhydrine 0
                  Strobamine 0
                  Trigonelline HCl 0
                  Voacamine 2
                  [(1S,3R,13S,14S,17S,18R,19R,20S,21S,23R,24R,25S)-19,21,24-triacetyloxy-18,25-dihydroxy-3,13,14,25-tetramethyl-6,15,22-trioxo-2,5,16-trioxa-11-azapentacyclo[15.7.1.01,20.03,23.07,12]pentacosa-7(12),8,10-trien-20-yl]methyl acetate 0
                  [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, (3Z,6R,14aR,14bR)- 0
                  oxystemokerrine 0
                  stemocurtisinol 0
                  stemokerrine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        divalent carboacyl group 12
                                          citraconoyl group 12
                                            (+)-dihydropinidine 0
                                            (-)-Sedamine 0
                                            (-)-Solenopsin A 0
                                            (-)-epidihydropinidine 0
                                            (-)-pinidinone 0
                                            (2S,4R,6R)-2-methyl-6-nonylpiperidin-4-ol 0
                                            (E)-2-methyl-4-((3aS)-1-methyl-2,3,8,8a-tetrahydropyrrolo[2,3-b]indol-3a(1H)-yl)but-2-en-1-ol 0
                                            2-(Pyridin-3-yl)piperidine-1-carbaldehyde 0
                                            2-pentyl-Piperidine 0
                                            6,6'-(1,2,3,5,8,8a-Hexahydroindolizine-6,8-diyldi-10,1-decanediyl)bis(2-methyl-3-piperidinol) 0
                                            Anapheline 0
                                            Anatalline 0
                                            Aquifoliunine EII 0
                                            Aquifoliunine EIII 0
                                            Arecaidine 1
                                            Brunsvigine 0
                                            Cassine 3
                                            Echinatine 0
                                            Elaeokanine C 0
                                            Epivoacorine 0
                                            Gabunine 0
                                            Heliosupine N-oxide 0
                                            Heliotridine viridiflorate N-oxide 0
                                            Heliotrine n-oxide 0
                                            Homoarecoline 0
                                            Hydroxysenkirkine 0
                                            Isatidine 0
                                            Juliflorine 0
                                            LSM-2853 0
                                            Lobelanidine 0
                                            Lyconnotine 0
                                            N'-Nitrosoanabasine 4
                                            N,N,N-Trimethylserotonin 0
                                            N-Methylpelletierine 0
                                            N-Nitrosoguvacine 0
                                            N-Nitrosoguvacoline 1
                                            Nangustine 0
                                            Neurine 0
                                            Nicotine imine 1
                                            Nupharamine 0
                                            O7-Angeloylretronecine 0
                                            Pancratistatin 1
                                            Pelletierine 0
                                            Pilosine 0
                                            Prosafrinine 0
                                            Pseudoconhydrine 0
                                            Strobamine 0
                                            Trigonelline HCl 0
                                            Voacamine 2
                                            [(1S,3R,13S,14S,17S,18R,19R,20S,21S,23R,24R,25S)-19,21,24-triacetyloxy-18,25-dihydroxy-3,13,14,25-tetramethyl-6,15,22-trioxo-2,5,16-trioxa-11-azapentacyclo[15.7.1.01,20.03,23.07,12]pentacosa-7(12),8,10-trien-20-yl]methyl acetate 0
                                            [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, (3Z,6R,14aR,14bR)- 0
                                            oxystemokerrine 0
                                            stemocurtisinol 0
                                            stemokerrine 0
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