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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cineole
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Accession:CHEBI:23243 term browser browse the term
Synonyms:related_synonym: cineoles


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1,8-cineole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of ACTR2 protein] CTD PMID:31483951 NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of CDC42 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of CDC42 protein] CTD PMID:31483951 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cttn cortactin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of CTTN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein] CTD PMID:31483951 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Eucalyptol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases hydroxylation
multiple interactions
ISO CYP3A4 protein results in increased hydroxylation of Eucalyptol
Eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
CTD PMID:15715982 PMID:18385293 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Eucalyptol CTD PMID:15715982 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Ezr ezrin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of EZR protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of EZR protein] CTD PMID:31483951 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]; RHOA protein inhibits the reaction [Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]] CTD PMID:31483951 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Eucalyptol results in decreased expression of HMGCR protein CTD PMID:24613879 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 protein] CTD PMID:29789401 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein] CTD PMID:29789401 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lep leptin multiple interactions ISO Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of EZR protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PTK2 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SRC protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SYNPO protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of TLN1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased abundance of Blood Glucose]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of CDC42 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of PXN protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RAC1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RHOA protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of ROCK1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of VCL protein modified form] CTD PMID:31483951 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK8 protein] CTD PMID:23872422 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK9 protein] CTD PMID:23872422 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Muc19 mucin 19, oligomeric decreases expression ISO Eucalyptol results in decreased expression of MUC19 mRNA CTD PMID:26207629 NCBI chr 7:133,048,727...133,166,551 JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC2 mRNA] CTD PMID:26207629 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein] CTD PMID:29215731 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides affects the expression of NFKBIA protein]; Eucalyptol inhibits the reaction [Lipopolysaccharides inhibits the reaction [RELA protein binds to NFKBIA protein]] CTD PMID:23872422 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of PTK2 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PTK2 protein] CTD PMID:31483951 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [Glucose results in increased expression of PXN protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of PXN protein modified form]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]] CTD PMID:31483951 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of RAC1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RAC1 protein] CTD PMID:31483951 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides inhibits the reaction [RELA protein binds to NFKBIA protein]] CTD PMID:23872422 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of RHOA protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RHOA protein]; RHOA protein inhibits the reaction [Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]] CTD PMID:31483951 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of ROCK1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of ROCK1 protein] CTD PMID:31483951 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Eucalyptol inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:84,335,594...84,360,354
Ensembl chr14:84,335,597...84,355,528
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of SRC protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SRC protein] CTD PMID:31483951 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Synpo synaptopodin multiple interactions ISO Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SYNPO protein] CTD PMID:31483951 NCBI chr18:55,863,081...55,921,412
Ensembl chr18:55,865,467...55,916,220
JBrowse link
G Tln1 talin 1 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of TLN1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of TLN1 protein] CTD PMID:31483951 NCBI chr 5:59,033,635...59,063,592
Ensembl chr 5:59,033,636...59,063,592
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
Eucalyptol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:23872422 PMID:26207629 PMID:29789401 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcl vinculin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [Glucose results in increased expression of VCL protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of VCL protein modified form]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]] CTD PMID:31483951 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
tea tree oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:15,198,950...15,225,547
Ensembl chr 7:15,198,940...15,225,410
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Tea Tree Oil results in increased activity of ESR1 protein CTD PMID:31393563 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO Tea Tree Oil results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]
CTD PMID:31393563 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G RGD1559459 similar to Expressed sequence AI788959 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:22,932,454...22,955,663
Ensembl chr14:22,937,421...22,952,822
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:84,335,594...84,360,354
Ensembl chr14:84,335,597...84,355,528
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        biochemical role 19370
          volatile oil component 6005
            cineole 37
              1,4-cineole 0
              1,8-cineole + 37
              1-methyl-2-[(2-methylbenzyl)oxy]-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane + 0
              2-endo-hydroxy-1,8-cineole 0
              2-exo-hydroxy-1,4-cineole 0
              2-exo-hydroxy-1,8-cineole 0
              6-oxocineole 0
              cinmethylin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    main group molecular entity 19771
                      s-block molecular entity 19520
                        hydrogen molecular entity 19512
                          hydrides 18784
                            organic hydride 18338
                              organic fundamental parent 18338
                                hydrocarbon 18064
                                  terpene 10292
                                    terpenoid 9620
                                      monoterpenoid 1194
                                        p-menthane monoterpenoid 431
                                          cineole 37
                                            1,4-cineole 0
                                            1,8-cineole + 37
                                            1-methyl-2-[(2-methylbenzyl)oxy]-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane + 0
                                            2-endo-hydroxy-1,8-cineole 0
                                            2-exo-hydroxy-1,4-cineole 0
                                            2-exo-hydroxy-1,8-cineole 0
                                            6-oxocineole 0
                                            cinmethylin 0
paths to the root