CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | chromanol |
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Accession: | CHEBI:23229
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browse the term
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Definition: | Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups. |
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A930009A15Rik |
RIKEN cDNA A930009A15 gene |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:17532611 |
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NCBI chr10:115,399,555...115,418,359
Ensembl chr10:115,405,891...115,418,353
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Abcb1a |
ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein] |
CTD |
PMID:24448832 |
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NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcd1 |
ATP-binding cassette, sub-family D (ALD), member 1 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD1 mRNA] |
CTD |
PMID:29065513 |
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NCBI chr X:72,760,203...72,782,140
Ensembl chr X:72,760,203...72,782,140
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Abcd3 |
ATP-binding cassette, sub-family D (ALD), member 3 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD3 mRNA] |
CTD |
PMID:29065513 |
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NCBI chr 3:121,552,553...121,609,851
Ensembl chr 3:121,552,423...121,608,951
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Acat1 |
acetyl-Coenzyme A acetyltransferase 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [iron(II)-ascorbic acid complex results in decreased activity of ACAT1 protein] |
CTD |
PMID:10656290 |
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NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
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Ache |
acetylcholinesterase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Streptozocin results in increased activity of ACHE protein] [alpha-Tocopherol co-treated with Paraoxon] results in decreased activity of ACHE protein; ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein]; alpha-Tocopherol binds to and results in decreased activity of ACHE protein; alpha-Tocopherol promotes the reaction [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in decreased activity of ACHE protein] |
CTD |
PMID:19464315 PMID:34506764 |
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NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Acvrl1 |
activin A receptor, type II-like 1 |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of ACVRL1 mRNA |
CTD |
PMID:16908007 |
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NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217
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Agt |
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:17532611 |
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NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
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Akr1b3 |
aldo-keto reductase family 1, member B3 (aldose reductase) |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of AKR1B1 mRNA |
CTD |
PMID:16908007 |
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NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
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Akt1 |
thymoma viral proto-oncogene 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased phosphorylation of and results in decreased activity of AKT1 protein] alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:19351882 PMID:22343715 |
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NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
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Alad |
aminolevulinate, delta-, dehydratase |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein] |
CTD |
PMID:7728901 |
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NCBI chr 4:62,424,221...62,438,300
Ensembl chr 4:62,427,406...62,438,155
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Alas1 |
aminolevulinic acid synthase 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein] |
CTD |
PMID:12180188 |
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NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853
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Alb |
albumin |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]; sodium-4,5-dihydroxy-1,3-benzene disulfonate promotes the reaction [alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]] ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein] |
CTD |
PMID:17429802 PMID:34506764 |
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NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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Ano6 |
anoctamin 6 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of ANO6 mRNA] |
CTD |
PMID:27886375 |
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NCBI chr15:95,688,724...95,873,353
Ensembl chr15:95,688,724...95,872,632
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Apex2 |
apurinic/apyrimidinic endonuclease 2 |
multiple interactions decreases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA] alpha-Tocopherol results in decreased expression of APEX2 mRNA |
CTD |
PMID:26332274 |
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NCBI chr X:149,286,625...149,371,175
Ensembl chr X:149,302,515...149,372,864
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Apoa1 |
apolipoprotein A-I |
decreases expression decreases activity |
ISO |
alpha-Tocopherol results in decreased expression of APOA1 mRNA; alpha-Tocopherol results in decreased expression of APOA1 protein alpha-Tocopherol results in decreased activity of APOA1 promoter |
CTD |
PMID:16423621 |
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NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
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Apob |
apolipoprotein B |
multiple interactions |
ISO |
alpha-Tocopherol promotes the reaction [APOB protein results in increased reduction of Copper] |
CTD |
PMID:11368321 |
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NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
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App |
amyloid beta (A4) precursor protein |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein] |
CTD |
PMID:12684028 |
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NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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Atf2 |
activating transcription factor 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:14645110 |
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NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
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Bace1 |
beta-site APP cleaving enzyme 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA] |
CTD |
PMID:19196431 |
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NCBI chr 9:45,749,843...45,774,791
Ensembl chr 9:45,749,878...45,775,697
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Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of BAD mRNA |
CTD |
PMID:26332274 |
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NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
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Bax |
BCL2-associated X protein |
multiple interactions increases expression |
ISO |
alpha-Tocopherol affects the reaction [Lipopolysaccharides results in increased expression of BAX protein] alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein] alpha-Tocopherol results in increased expression of BAX mRNA |
CTD |
PMID:11805214 PMID:26332274 PMID:32134168 |
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NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
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Bche |
butyrylcholinesterase |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Endosulfan results in decreased activity of BCHE protein] |
CTD |
PMID:24299906 |
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NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
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Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions decreases expression |
ISO |
alpha-Tocopherol affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; TNFRSF10B mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] alpha-Tocopherol analog results in decreased expression of BCL2 mRNA; alpha-Tocopherol analog results in decreased expression of BCL2 protein alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein] |
CTD |
PMID:11805214 PMID:16005924 PMID:16135673 PMID:20686688 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Bcl2l1 |
BCL2-like 1 |
decreases expression |
ISO |
alpha-Tocopherol results in decreased expression of BCL2L1 protein |
CTD |
PMID:18942769 |
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NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
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Bdnf |
brain derived neurotrophic factor |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein] |
CTD |
PMID:30776390 |
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NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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Canx |
calnexin |
affects localization increases expression |
ISO |
alpha-Tocopherol affects the localization of CANX protein alpha-Tocopherol results in increased expression of CANX mRNA; alpha-Tocopherol results in increased expression of CANX protein |
CTD |
PMID:16908007 |
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NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500
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Casp3 |
caspase 3 |
multiple interactions decreases activity |
ISO EXP |
[alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein; [alpha-Tocopherol co-treated with Tretinoin] results in increased activity of CASP3 protein; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased cleavage of and results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Vitamin A results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP3 protein [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein] [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 protein] alpha-Tocopherol results in decreased activity of CASP3 protein |
CTD |
PMID:12450566 PMID:14599462 PMID:14722101 PMID:15095415 PMID:17618090 PMID:17874176 PMID:17936189 PMID:21869839 PMID:22389237 PMID:23042730 PMID:29065513 PMID:29129777 PMID:30776390 PMID:31712109 PMID:32134168 More...
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp7 |
caspase 7 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]] |
CTD |
PMID:23042730 PMID:29129777 |
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NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
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Casp8 |
caspase 8 |
increases cleavage |
ISO |
alpha-Tocopherol analog results in increased cleavage of CASP8 protein |
CTD |
PMID:20686688 |
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NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662
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Casp9 |
caspase 9 |
increases cleavage multiple interactions |
ISO EXP |
alpha-Tocopherol analog results in increased cleavage of CASP9 protein alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein] alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:20686688 PMID:21869839 PMID:31712109 |
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Cat |
catalase |
multiple interactions increases activity increases expression |
ISO |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Sodium Selenite co-treated with alpha-Tocopherol] inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [Copper Sulfate results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [flubendiamide results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Streptozocin results in decreased expression of CAT protein] alpha-Tocopherol results in increased activity of CAT protein alpha-Tocopherol results in increased expression of CAT protein alpha-Tocopherol results in increased expression of CAT mRNA; alpha-Tocopherol results in increased expression of CAT protein |
CTD |
PMID:9306888 PMID:16979807 PMID:18547560 PMID:19083475 PMID:19464315 PMID:19941068 PMID:20194575 PMID:21322096 PMID:22732938 PMID:27823922 PMID:30057697 PMID:31022331 More...
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Cav1 |
caveolin 1, caveolae protein |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA] |
CTD |
PMID:27257344 |
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NCBI chr 6:17,306,287...17,341,327
Ensembl chr 6:17,306,334...17,341,451
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Ccl2 |
chemokine (C-C motif) ligand 2 |
multiple interactions |
EXP ISO |
alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein] alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] |
CTD |
PMID:19735175 PMID:24333275 PMID:26332274 |
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NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA] |
CTD |
PMID:26332274 |
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NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccnd2 |
cyclin D2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA] |
CTD |
PMID:26332274 |
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NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
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Cd36 |
CD36 molecule |
affects expression multiple interactions |
ISO |
alpha-Tocopherol affects the expression of CD36 mRNA alpha-Tocopherol inhibits the reaction [[troglitazone co-treated with Ethanol] results in increased expression of CD36 protein] |
CTD |
PMID:16407258 |
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NCBI chr 5:17,986,688...18,093,957
Ensembl chr 5:17,986,688...18,093,799
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A (P21) |
multiple interactions decreases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA] alpha-Tocopherol results in decreased expression of CDKN1A mRNA |
CTD |
PMID:26332274 |
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NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cftr |
cystic fibrosis transmembrane conductance regulator |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Cadmium results in decreased expression of CFTR protein] |
CTD |
PMID:20363832 |
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NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
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Chat |
choline acetyltransferase |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein; Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein] |
CTD |
PMID:25891525 |
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NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
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Clcn3 |
chloride channel, voltage-sensitive 3 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of CLCN3 mRNA] |
CTD |
PMID:27886375 |
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NCBI chr 8:61,363,423...61,436,353
Ensembl chr 8:61,363,423...61,436,334
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Cldn2 |
claudin 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Potassium Dichromate affects the localization of CLDN2 protein] |
CTD |
PMID:19766176 |
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NCBI chr X:138,701,555...138,712,135
Ensembl chr X:138,701,577...138,712,135
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Cpt1a |
carnitine palmitoyltransferase 1a, liver |
multiple interactions increases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CPT1A mRNA]; alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA] alpha-Tocopherol results in increased expression of CPT1A mRNA |
CTD |
PMID:17936189 |
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NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
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Crabp2 |
cellular retinoic acid binding protein II |
multiple interactions |
ISO |
[Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 mRNA; [Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 protein |
CTD |
PMID:15225641 |
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NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
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Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:30776390 |
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NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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Crp |
C-reactive protein, pentraxin-related |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein |
CTD |
PMID:18191645 |
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NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
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Cryaa |
crystallin, alpha A |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of CRYAA mRNA |
CTD |
PMID:16908007 |
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NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707
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Ctsd |
cathepsin D |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of CTSD protein |
CTD |
PMID:18942769 |
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NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
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Cxcl1 |
chemokine (C-X-C motif) ligand 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA] |
CTD |
PMID:24333275 |
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NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
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Cxcl15 |
chemokine (C-X-C motif) ligand 15 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA] |
CTD |
PMID:19135038 PMID:25551565 |
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NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Cxcl2 |
chemokine (C-X-C motif) ligand 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] |
CTD |
PMID:24333275 |
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NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
alpha-Tocopherol results in increased expression of CYP1A1 mRNA [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]; alpha-Tocopherol results in increased expression of and results in increased activity of CYP1A1 protein |
CTD |
PMID:15665910 PMID:22389237 |
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NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity multiple interactions |
ISO EXP |
alpha-Tocopherol results in increased activity of CYP1A2 protein alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:15665910 PMID:26102010 |
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NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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G |
Cyp2b10 |
cytochrome P450, family 2, subfamily b, polypeptide 10 |
decreases expression |
EXP |
alpha-Tocopherol results in decreased expression of CYP2B10 mRNA |
CTD |
PMID:26102010 |
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NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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G |
Cyp2b9 |
cytochrome P450, family 2, subfamily b, polypeptide 9 |
decreases expression |
EXP |
alpha-Tocopherol results in decreased expression of CYP2B9 mRNA |
CTD |
PMID:26102010 |
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NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086
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G |
Cyp2c29 |
cytochrome P450, family 2, subfamily c, polypeptide 29 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] |
CTD |
PMID:26102010 |
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NCBI chr19:39,275,488...39,319,157
Ensembl chr19:39,257,849...39,319,157
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression multiple interactions |
ISO |
alpha-Tocopherol results in increased expression of CYP2E1 mRNA [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA] |
CTD |
PMID:26332274 PMID:27919644 PMID:28062356 |
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NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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G |
Cyp3a11 |
cytochrome P450, family 3, subfamily a, polypeptide 11 |
increases expression multiple interactions |
EXP ISO |
alpha-Tocopherol results in increased expression of CYP3A11; alpha-Tocopherol results in increased expression of CYP3A11 mRNA; alpha-Tocopherol results in increased expression of CYP3A11 protein alpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone] alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA] |
CTD |
PMID:15649653 PMID:16008107 PMID:26102010 PMID:31102695 |
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NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
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G |
Cyp3a13 |
cytochrome P450, family 3, subfamily a, polypeptide 13 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of CYP3A13 mRNA; alpha-Tocopherol results in increased expression of CYP3A13 protein |
CTD |
PMID:26102010 |
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NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] alpha-Tocopherol analog results in increased expression of DDIT3 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein] |
CTD |
PMID:20459685 PMID:20686688 |
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NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
affects localization |
EXP |
alpha-Tocopherol affects the localization of DIABLO protein |
CTD |
PMID:15582575 |
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NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases phosphorylation multiple interactions |
ISO |
alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:20686688 |
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NCBI chr 3:58,433,242...58,464,922
Ensembl chr 3:58,433,242...58,464,922
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G |
Esr1 |
estrogen receptor 1 (alpha) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] |
CTD |
PMID:22389237 |
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NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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G |
Esr2 |
estrogen receptor 2 (beta) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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G |
Fasl |
Fas ligand (TNF superfamily, member 6) |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of FASLG mRNA |
CTD |
PMID:26332274 |
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NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
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G |
Fbl |
fibrillarin |
decreases expression |
ISO |
alpha-Tocopherol deficiency results in decreased expression of FBL protein |
CTD |
PMID:15247049 |
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NCBI chr 7:27,868,345...27,878,694
Ensembl chr 7:27,869,135...27,878,694
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G |
Fmo1 |
flavin containing monooxygenase 1 |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of FMO1 mRNA |
CTD |
PMID:16908007 |
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NCBI chr 1:162,657,130...162,694,179
Ensembl chr 1:162,657,130...162,694,179
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein] |
CTD |
PMID:9225831 |
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NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
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G |
Fyn |
Fyn proto-oncogene |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] |
CTD |
PMID:14572611 |
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NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
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G |
Gadd45a |
growth arrest and DNA-damage-inducible 45 alpha |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of GADD45A mRNA |
CTD |
PMID:26332274 |
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NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA |
CTD |
PMID:24530478 |
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NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
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G |
Gclm |
glutamate-cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLM mRNA |
CTD |
PMID:22389237 PMID:24530478 |
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NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
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G |
Gfap |
glial fibrillary acidic protein |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of GFAP protein |
CTD |
PMID:18942769 |
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NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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G |
Gnai2 |
guanine nucleotide binding protein (G protein), alpha inhibiting 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI2 protein] |
CTD |
PMID:18441196 |
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NCBI chr 9:107,491,324...107,512,617
Ensembl chr 9:107,491,324...107,512,566
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G |
Gnai3 |
guanine nucleotide binding protein (G protein), alpha inhibiting 3 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI3 protein] |
CTD |
PMID:18441196 |
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NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462
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G |
Gpt |
glutamic pyruvic transaminase, soluble |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [beryllium nitrate results in increased activity of GPT protein] |
CTD |
PMID:17429802 |
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NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] |
CTD |
PMID:14642406 |
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NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
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G |
Gsr |
glutathione reductase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GSR protein] |
CTD |
PMID:16979807 |
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NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
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G |
Gstm1 |
glutathione S-transferase, mu 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
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G |
Gstt1 |
glutathione S-transferase, theta 1 |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of GSTT1 protein |
CTD |
PMID:9855024 |
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NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
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G |
Gusb |
glucuronidase, beta |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] |
CTD |
PMID:19135433 |
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NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890
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G |
Hal |
histidine ammonia lyase |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of HAL mRNA |
CTD |
PMID:16908007 |
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NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
multiple interactions |
ISO |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] |
CTD |
PMID:19595682 PMID:21535577 |
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NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
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G |
Hmox1 |
heme oxygenase 1 |
affects expression multiple interactions |
ISO |
alpha-Tocopherol affects the expression of HMOX1 mRNA [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of HMOX1 protein] alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein] |
CTD |
PMID:8743975 PMID:12180188 PMID:22053912 PMID:22389237 |
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Hp |
haptoglobin |
affects activity multiple interactions |
ISO EXP |
alpha-Tocopherol affects the activity of HP protein polymorphism Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism] |
CTD |
PMID:19769483 |
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NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of HSD17B3 mRNA] |
CTD |
PMID:32134168 |
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NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of HSD3B2 mRNA] |
CTD |
PMID:32134168 |
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NCBI chr 3:98,618,423...98,631,859
Ensembl chr 3:98,616,571...98,631,859
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G |
Hspa1b |
heat shock protein 1B |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of HSPA1B mRNA |
CTD |
PMID:16908007 |
|
NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein] |
CTD |
PMID:22313677 PMID:25551565 |
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NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IFNG mRNA; alpha-Tocopherol results in decreased susceptibility to [IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] |
CTD |
PMID:16307444 PMID:24333275 |
|
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA |
CTD |
PMID:23859036 |
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NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043
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G |
Ikbkb |
inhibitor of kappaB kinase beta |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:34310962 |
|
NCBI chr 8:23,149,221...23,196,605
Ensembl chr 8:23,149,228...23,196,605
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein] [alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IL10 mRNA |
CTD |
PMID:24333275 PMID:25551565 |
|
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein] |
CTD |
PMID:15025948 |
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NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of IL1B mRNA] alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA] |
CTD |
PMID:19135433 PMID:19735175 PMID:26332274 PMID:31712109 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
alpha-Tocopherol inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of IL6 protein] alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of IL6 protein] alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:15630180 PMID:24296301 PMID:32134168 |
|
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Jun |
jun proto-oncogene |
multiple interactions increases expression |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of JUN protein] alpha-Tocopherol results in increased expression of JUN mRNA; alpha-Tocopherol results in increased expression of JUN protein |
CTD |
PMID:14645110 PMID:19000923 PMID:20025956 |
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NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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G |
Kcnh2 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased activity of KCNH2 protein] |
CTD |
PMID:12531891 |
|
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions |
ISO |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in decreased activity of LCAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] |
CTD |
PMID:19595682 PMID:21535577 |
|
NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014
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G |
Lck |
lymphocyte protein tyrosine kinase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] |
CTD |
PMID:14572611 |
|
NCBI chr 4:129,442,137...129,467,434
Ensembl chr 4:129,442,137...129,467,434
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
ISO |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHA protein] |
CTD |
PMID:21322096 |
|
NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
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G |
Ldhb |
lactate dehydrogenase B |
multiple interactions |
ISO |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] |
CTD |
PMID:21322096 |
|
NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] |
CTD |
PMID:14572611 |
|
NCBI chr 4:3,676,865...3,791,612
Ensembl chr 4:3,678,115...3,813,122
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions affects activity |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK1 protein] [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK1 protein] [alpha-Tocopherol affects the activity of MAPK1 protein] which results in decreased susceptibility to Potassium Dichromate |
CTD |
PMID:17011908 PMID:19766176 PMID:30776390 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk14 |
mitogen-activated protein kinase 14 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK14 protein] |
CTD |
PMID:12684028 PMID:14645110 |
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NCBI chr17:28,910,243...28,967,379
Ensembl chr17:28,910,303...28,967,380
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|
G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions affects activity |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK3 protein] [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK3 protein] [alpha-Tocopherol affects the activity of MAPK3 protein] which results in decreased susceptibility to Potassium Dichromate |
CTD |
PMID:14645110 PMID:17011908 PMID:19766176 PMID:30776390 |
|
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:12684028 PMID:14645110 PMID:20686688 |
|
NCBI chr14:33,099,855...33,169,215
Ensembl chr14:33,099,855...33,169,115
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|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation multiple interactions |
ISO |
alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:20686688 |
|
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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|
G |
Mb |
myoglobin |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride] |
CTD |
PMID:17478120 |
|
NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870
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|
G |
Mbp |
myelin basic protein |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein] |
CTD |
PMID:14645110 |
|
NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
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|
G |
Mgat3 |
mannoside acetylglucosaminyltransferase 3 |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of MGAT3 mRNA |
CTD |
PMID:16908007 |
|
NCBI chr15:80,057,852...80,099,720
Ensembl chr15:80,057,922...80,099,720
|
|
G |
Mki67 |
antigen identified by monoclonal antibody Ki 67 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA |
CTD |
PMID:23859036 |
|
NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
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|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] |
CTD |
PMID:31022331 |
|
NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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G |
Muc5ac |
mucin 5, subtypes A and C, tracheobronchial/gastric |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA] |
CTD |
PMID:24333275 |
|
NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
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G |
Myc |
myelocytomatosis oncogene |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein] |
CTD |
PMID:16005924 |
|
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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G |
Nefh |
neurofilament, heavy polypeptide |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of NEFH protein modified form |
CTD |
PMID:18942769 |
|
NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]; [alpha-Tocopherol co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of NFE2L2 protein] |
CTD |
PMID:22389237 PMID:31412289 PMID:32134168 |
|
NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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|
G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
multiple interactions increases activity |
ISO |
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]] alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]] alpha-Tocopherol results in increased activity of NFKB1 protein |
CTD |
PMID:15025948 PMID:16135673 PMID:17936189 PMID:19083475 |
|
NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308
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G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
multiple interactions |
EXP ISO |
alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; alpha-Tocopherol inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein] [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:16135673 PMID:17532611 PMID:25551565 |
|
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
|
|
G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions |
EXP ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein] alpha-Tocopherol inhibits the reaction [Galactosamine results in increased expression of NOS2 mRNA] |
CTD |
PMID:17936189 PMID:19135433 |
|
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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G |
Nos3 |
nitric oxide synthase 3, endothelial cell |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of NOS3 mRNA; alpha-Tocopherol results in increased expression of NOS3 protein |
CTD |
PMID:16949522 |
|
NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
|
|
G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] |
CTD |
PMID:22389237 |
|
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA] |
CTD |
PMID:17936189 |
|
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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G |
Ogdh |
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [sodium arsenite results in decreased activity of OGDH protein] |
CTD |
PMID:12915223 |
|
NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642
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G |
Orm1 |
orosomucoid 1 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of ORM1 mRNA; alpha-Tocopherol results in increased expression of ORM1 protein |
CTD |
PMID:19000923 PMID:20025956 |
|
NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400
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G |
Park7 |
Parkinson disease (autosomal recessive, early onset) 7 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein] |
CTD |
PMID:16439141 |
|
NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
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G |
Parp1 |
poly (ADP-ribose) polymerase family, member 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein] alpha-Tocopherol inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein] |
CTD |
PMID:14645110 PMID:24448832 |
|
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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G |
Pawr |
PRKC, apoptosis, WT1, regulator |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein] |
CTD |
PMID:10428045 |
|
NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101
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G |
Pax3 |
paired box 3 |
multiple interactions increases expression |
EXP |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA] alpha-Tocopherol results in increased expression of PAX3 mRNA |
CTD |
PMID:12739027 |
|
NCBI chr 1:78,077,904...78,173,773
Ensembl chr 1:78,077,904...78,173,771
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1, cytosolic |
decreases expression |
ISO |
alpha-Tocopherol results in decreased expression of PCK1 mRNA |
CTD |
PMID:11597575 |
|
NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] |
CTD |
PMID:22389237 |
|
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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G |
Pdgfrb |
platelet derived growth factor receptor, beta polypeptide |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein |
CTD |
PMID:23859036 |
|
NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
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G |
Pgk1 |
phosphoglycerate kinase 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] |
CTD |
PMID:18603805 |
|
NCBI chr X:105,230,706...105,247,305
Ensembl chr X:105,230,706...105,247,305
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G |
Plg |
plasminogen |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]; alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein] |
CTD |
PMID:11419606 |
|
NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272
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G |
Pltp |
phospholipid transfer protein |
decreases abundance |
EXP |
PLTP mutant form results in decreased abundance of alpha-Tocopherol |
CTD |
PMID:16675720 |
|
NCBI chr 2:164,681,438...164,699,628
Ensembl chr 2:164,681,438...164,699,631
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions increases expression |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of PPARA mRNA] alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA] alpha-Tocopherol results in increased expression of PPARA mRNA |
CTD |
PMID:17936189 PMID:29065513 |
|
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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G |
Pparg |
peroxisome proliferator activated receptor gamma |
increases expression multiple interactions increases activity |
ISO |
alpha-Tocopherol results in increased expression of PPARG mRNA; alpha-Tocopherol results in increased expression of PPARG protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein] alpha-Tocopherol results in increased activity of PPARG protein |
CTD |
PMID:11752099 PMID:14521714 PMID:19083475 PMID:22389237 PMID:28062356 |
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NCBI chr 6:115,337,840...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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G |
Ppia |
peptidylprolyl isomerase A |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of PPIA mRNA |
CTD |
PMID:16908007 |
|
NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817
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G |
Prl2c3 |
prolactin family 2, subfamily c, member 3 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of PRL2C3 protein |
CTD |
PMID:20025956 |
|
NCBI chr13:12,805,705...12,814,982
Ensembl chr13:12,805,705...12,814,968
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G |
Psmc6 |
proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein] |
CTD |
PMID:17532611 |
|
NCBI chr14:45,567,280...45,587,138
Ensembl chr14:45,567,245...45,587,162
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases activity multiple interactions |
ISO |
alpha-Tocopherol metabolite results in decreased activity of PTGS2 protein; alpha-Tocopherol results in decreased activity of PTGS2 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein] |
CTD |
PMID:15225597 PMID:22389237 |
|
NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
affects localization multiple interactions |
ISO |
alpha-Tocopherol affects the localization of RELA protein alpha-Tocopherol affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]] alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:15025948 PMID:16135673 PMID:16882165 PMID:17936189 PMID:34310962 |
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NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Rps6 |
ribosomal protein S6 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein] |
CTD |
PMID:22343715 |
|
NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
[Tretinoin co-treated with alpha-Tocopherol co-treated with Okadaic Acid] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with alpha-Tocopherol] results in decreased phosphorylation of RXRA protein |
CTD |
PMID:15225641 |
|
NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
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G |
Sele |
selectin, endothelial cell |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of SELE protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA] |
CTD |
PMID:12566129 PMID:25551565 |
|
NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,803...163,885,246
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G |
Slc1a2 |
solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein] |
CTD |
PMID:34310962 |
|
NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129
|
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G |
Slc7a11 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA; [alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 protein |
CTD |
PMID:24530478 |
|
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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|
G |
Smad4 |
SMAD family member 4 |
multiple interactions |
ISO |
SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol] |
CTD |
PMID:20562578 |
|
NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851
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G |
Snca |
synuclein, alpha |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:16439141 |
|
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
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G |
Sod1 |
superoxide dismutase 1, soluble |
multiple interactions increases expression |
ISO |
[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of SOD1 protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein] alpha-Tocopherol results in increased expression of SOD1 mRNA; alpha-Tocopherol results in increased expression of SOD1 protein |
CTD |
PMID:19083475 PMID:20194575 PMID:21344382 PMID:22732938 |
|
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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G |
Sod2 |
superoxide dismutase 2, mitochondrial |
decreases expression increases expression multiple interactions |
ISO |
alpha-Tocopherol results in decreased expression of SOD2 protein alpha-Tocopherol results in increased expression of SOD2 mRNA; alpha-Tocopherol results in increased expression of SOD2 protein [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein] |
CTD |
PMID:16135673 PMID:18942769 PMID:20194575 PMID:22732938 PMID:23859036 |
|
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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G |
Srsf2 |
serine and arginine-rich splicing factor 2 |
decreases expression |
ISO |
alpha-Tocopherol deficiency results in decreased expression of SRSF2 protein |
CTD |
PMID:15247049 |
|
NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920
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|
G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of STAR mRNA] |
CTD |
PMID:32134168 |
|
NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
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|
G |
Stat3 |
signal transducer and activator of transcription 3 |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of STAT3 mRNA |
CTD |
PMID:16908007 |
|
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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|
G |
Tert |
telomerase reverse transcriptase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased activity of TERT protein] |
CTD |
PMID:20112180 |
|
NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962
|
|
G |
Tgfa |
transforming growth factor alpha |
decreases response to substance |
ISO |
alpha-Tocopherol results in decreased susceptibility to TGFA protein |
CTD |
PMID:7593635 |
|
NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
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|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression |
ISO |
alpha-Tocopherol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species] alpha-Tocopherol results in decreased expression of TGFB1 mRNA |
CTD |
PMID:9608545 PMID:14732287 |
|
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
|
|
G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein; alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein] |
CTD |
PMID:15790535 PMID:25891525 |
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NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
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G |
Tnf |
tumor necrosis factor |
multiple interactions affects expression decreases response to substance decreases expression |
ISO EXP |
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein] alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein] alpha-Tocopherol affects the expression of TNF protein alpha-Tocopherol results in decreased susceptibility to TNF protein [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of TNF mRNA] alpha-Tocopherol results in decreased expression of TNF protein |
CTD |
PMID:10588948 PMID:11805214 PMID:12195823 PMID:15025948 PMID:15630180 PMID:16135673 PMID:16750838 PMID:18191645 PMID:19135038 PMID:19135433 PMID:19735175 PMID:23042730 PMID:25551565 PMID:26332274 PMID:30776390 PMID:31712109 PMID:32134168 PMID:34310962 More...
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Trp53 |
transformation related protein 53 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 mRNA]; alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 protein] |
CTD |
PMID:12126965 |
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NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of TXN1 protein] |
CTD |
PMID:21344382 |
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NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of VCAM1 protein]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein] |
CTD |
PMID:12566129 PMID:22313677 |
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NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
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G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
alpha-Tocopherol analog results in increased expression of XBP1 mRNA |
CTD |
PMID:20686688 |
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NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
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G |
Xrcc6 |
X-ray repair complementing defective repair in Chinese hamster cells 6 |
multiple interactions |
ISO |
alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA] |
CTD |
PMID:26332274 |
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NCBI chr15:81,868,805...81,924,286
Ensembl chr15:81,872,036...81,924,286
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G |
Yy1 |
YY1 transcription factor |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein] |
CTD |
PMID:34310962 |
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NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074
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G |
Abcb1a |
ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
increases expression |
ISO |
tocotrienol, alpha results in increased expression of ABCB1 |
CTD |
PMID:15269186 |
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NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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G |
Cyp3a11 |
cytochrome P450, family 3, subfamily a, polypeptide 11 |
multiple interactions affects response to substance |
ISO |
tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid] CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, alpha |
CTD |
PMID:31102695 |
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NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
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G |
Gstm1 |
glutathione S-transferase, mu 1 |
multiple interactions |
ISO |
GSTM1 gene polymorphism affects the susceptibility to [Ascorbic Acid co-treated with tocotrienol, alpha] |
CTD |
PMID:15668500 |
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NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
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G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] |
CTD |
PMID:15269186 |
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NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
tocotrienol, alpha binds to and results in increased activity of NR1I2 protein; tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] |
CTD |
PMID:15269186 |
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NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
increases expression |
ISO |
tocotrienol, alpha results in increased expression of UGT1A1 |
CTD |
PMID:15269186 |
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NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein] beta-Tocopherol affects the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; beta-Tocopherol affects the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein] |
CTD |
PMID:12450566 PMID:22389237 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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G |
Esr1 |
estrogen receptor 1 (alpha) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] |
CTD |
PMID:22389237 |
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NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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G |
Esr2 |
estrogen receptor 2 (beta) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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G |
Gclm |
glutamate-cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
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G |
Gstm1 |
glutathione S-transferase, mu 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein] |
CTD |
PMID:22389237 |
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein] |
CTD |
PMID:22389237 |
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NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] |
CTD |
PMID:22389237 |
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NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] |
CTD |
PMID:22389237 |
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NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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G |
Pparg |
peroxisome proliferator activated receptor gamma |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein] |
CTD |
PMID:22389237 |
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NCBI chr 6:115,337,840...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein] |
CTD |
PMID:22389237 |
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NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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G |
Abcb1a |
ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
increases expression |
ISO |
tocotrienol, beta results in increased expression of ABCB1 |
CTD |
PMID:15269186 |
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NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
tocotrienol, beta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] |
CTD |
PMID:15269186 |
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NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
tocotrienol, beta binds to and results in increased activity of NR1I2 protein; tocotrienol, beta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] |
CTD |
PMID:15269186 |
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NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
increases expression |
ISO |
tocotrienol, beta results in increased expression of UGT1A1 |
CTD |
PMID:15269186 |
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NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein] |
CTD |
PMID:22389237 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Crabp2 |
cellular retinoic acid binding protein II |
multiple interactions |
ISO |
[Tretinoin co-treated with delta-tocopherol] results in increased expression of CRABP2 mRNA |
CTD |
PMID:15225641 |
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NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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G |
Esr1 |
estrogen receptor 1 (alpha) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] |
CTD |
PMID:22389237 |
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NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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G |
Esr2 |
estrogen receptor 2 (beta) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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G |
Gclm |
glutamate-cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
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G |
Gstm1 |
glutathione S-transferase, mu 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein] |
CTD |
PMID:22389237 |
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein] |
CTD |
PMID:22389237 |
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NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] |
CTD |
PMID:22389237 |
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NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] |
CTD |
PMID:22389237 |
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NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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G |
Pparg |
peroxisome proliferator activated receptor gamma |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein] |
CTD |
PMID:22389237 |
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NCBI chr 6:115,337,840...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein] |
CTD |
PMID:22389237 |
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NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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G |
Abcb1a |
ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
increases expression |
ISO |
tocotrienol, delta results in increased expression of ABCB1 |
CTD |
PMID:15269186 |
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NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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G |
Abcc1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ABCC1 mRNA] tocotrienol, delta results in increased expression of ABCC1 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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G |
Abcd2 |
ATP-binding cassette, sub-family D (ALD), member 2 |
decreases expression |
EXP |
tocotrienol, delta results in decreased expression of ABCD2 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr15:91,029,878...91,076,706
Ensembl chr15:91,030,074...91,076,002
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|
G |
Actl6b |
actin-like 6B |
increases expression |
EXP |
tocotrienol, delta results in increased expression of ACTL6B mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 5:137,551,623...137,567,844
Ensembl chr 5:137,551,779...137,567,844
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|
G |
Atp2a2 |
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
increases expression |
EXP |
tocotrienol, delta results in increased expression of ATP2A2 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288
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|
G |
Ccl8 |
chemokine (C-C motif) ligand 8 |
multiple interactions decreases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCL8 mRNA] tocotrienol, delta results in decreased expression of CCL8 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr11:82,006,011...82,007,625
Ensembl chr11:82,006,011...82,007,625
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|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
tocotrienol, delta results in decreased expression of CCND1 protein |
CTD |
PMID:21453743 |
|
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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|
G |
Ccnd2 |
cyclin D2 |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA] tocotrienol, delta results in increased expression of CCND2 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
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|
G |
Cd40 |
CD40 antigen |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] tocotrienol, delta results in increased expression of CD40 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
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|
G |
Cd69 |
CD69 antigen |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA] tocotrienol, delta results in increased expression of CD69 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399
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|
G |
Cox7b2 |
cytochrome c oxidase subunit 7B2 |
multiple interactions decreases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA] tocotrienol, delta results in decreased expression of COX7B2 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 5:71,600,166...71,705,548
Ensembl chr 5:71,600,167...71,705,548
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|
G |
Crp |
C-reactive protein, pentraxin-related |
multiple interactions |
ISO |
[resveratrol co-treated with pterostilbene co-treated with Quercetin co-treated with tocotrienol, delta co-treated with Niacin] results in decreased expression of CRP protein |
CTD |
PMID:24319627 |
|
NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
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|
G |
Ctnnb1 |
catenin (cadherin associated protein), beta 1 |
decreases expression |
ISO |
tocotrienol, delta results in decreased expression of CTNNB1 protein |
CTD |
PMID:21453743 |
|
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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|
G |
Cyp3a11 |
cytochrome P450, family 3, subfamily a, polypeptide 11 |
multiple interactions affects response to substance |
ISO |
tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid] CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, delta |
CTD |
PMID:31102695 |
|
NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
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|
G |
Gimap1 |
GTPase, IMAP family member 1 |
multiple interactions decreases expression |
EXP |
tocotrienol, delta promotes the reaction [Lipopolysaccharides results in decreased expression of GIMAP1 mRNA] tocotrienol, delta results in decreased expression of GIMAP1 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 6:48,715,981...48,720,729
Ensembl chr 6:48,715,988...48,720,729
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression multiple interactions |
EXP |
tocotrienol, delta results in decreased expression of ICAM1 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] |
CTD |
PMID:22185406 |
|
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
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|
G |
Ifnb1 |
interferon beta 1, fibroblast |
multiple interactions |
EXP |
tocotrienol, delta inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] |
CTD |
PMID:22185406 |
|
NCBI chr 4:88,440,262...88,441,031
Ensembl chr 4:88,440,262...88,441,011
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|
G |
Ifng |
interferon gamma |
multiple interactions |
EXP |
tocotrienol, delta inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] |
CTD |
PMID:22185406 |
|
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Ifngr1 |
interferon gamma receptor 1 |
decreases expression multiple interactions |
EXP |
tocotrienol, delta results in decreased expression of IFNGR1 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA] |
CTD |
PMID:22185406 |
|
NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977
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|
G |
Il12b |
interleukin 12b |
decreases expression multiple interactions |
EXP |
tocotrienol, delta results in decreased expression of IL12B mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] |
CTD |
PMID:22185406 |
|
NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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|
G |
Il1a |
interleukin 1 alpha |
increases expression |
EXP |
tocotrienol, delta results in increased expression of IL1A mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] tocotrienol, delta results in increased expression of IL1B mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il1rn |
interleukin 1 receptor antagonist |
increases expression multiple interactions |
EXP |
tocotrienol, delta results in increased expression of IL1RN mRNA tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA] |
CTD |
PMID:22185406 |
|
NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
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|
G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
EXP |
tocotrienol, delta results in increased expression of IL6 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] |
CTD |
PMID:22185406 |
|
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Jun |
jun proto-oncogene |
decreases expression |
ISO |
tocotrienol, delta results in decreased expression of JUN protein |
CTD |
PMID:21453743 |
|
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
tocotrienol, delta results in decreased expression of MMP7 protein |
CTD |
PMID:21453743 |
|
NCBI chr 9:7,692,091...7,699,586
Ensembl chr 9:7,692,091...7,699,586
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|
G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] |
CTD |
PMID:15269186 |
|
NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367
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|
G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions |
EXP |
Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of NOS2]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:21356098 PMID:22185406 |
|
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
tocotrienol, delta binds to and results in increased activity of NR1I2 protein; tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] |
CTD |
PMID:15269186 |
|
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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G |
Phka2 |
phosphorylase kinase alpha 2 |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PHKA2 mRNA] tocotrienol, delta results in increased expression of PHKA2 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr X:159,284,900...159,384,772
Ensembl chr X:159,285,162...159,381,874
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G |
Psmb2 |
proteasome (prosome, macropain) subunit, beta type 2 |
decreases expression |
EXP |
tocotrienol, delta results in decreased expression of PSMB2 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 4:126,571,421...126,603,508
Ensembl chr 4:126,571,423...126,603,507
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|
G |
Ptbp2 |
polypyrimidine tract binding protein 2 |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA] tocotrienol, delta results in increased expression of PTBP2 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 3:119,512,390...119,578,296
Ensembl chr 3:119,512,391...119,578,115
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|
G |
Rasgrp1 |
RAS guanyl releasing protein 1 |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of RASGRP1 mRNA] tocotrienol, delta results in increased expression of RASGRP1 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482
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|
G |
Rasgrp3 |
RAS, guanyl releasing protein 3 |
decreases expression multiple interactions |
EXP |
tocotrienol, delta results in decreased expression of RASGRP3 mRNA tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA] |
CTD |
PMID:22185406 |
|
NCBI chr17:75,742,849...75,836,049
Ensembl chr17:75,742,891...75,836,049
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions decreases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA] tocotrienol, delta results in decreased expression of SOCS3 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
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|
G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions |
EXP |
tocotrienol, delta results in decreased expression of TNF mRNA Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of TNF]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:21356098 PMID:22185406 |
|
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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|
G |
Tnp1 |
transition protein 1 |
multiple interactions decreases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of TNP1 mRNA] tocotrienol, delta results in decreased expression of TNP1 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 1:73,054,233...73,055,058
Ensembl chr 1:73,054,233...73,055,068
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|
G |
Traf1 |
TNF receptor-associated factor 1 |
multiple interactions increases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA] tocotrienol, delta results in increased expression of TRAF1 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
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G |
Ube2d2a |
ubiquitin-conjugating enzyme E2D 2A |
multiple interactions decreases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of UBE2D2A mRNA] tocotrienol, delta results in decreased expression of UBE2D2A mRNA |
CTD |
PMID:22185406 |
|
NCBI chr18:35,904,612...35,940,225
Ensembl chr18:35,904,611...35,942,547
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
increases expression |
ISO |
tocotrienol, delta results in increased expression of UGT1A1 |
CTD |
PMID:15269186 |
|
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions decreases expression |
EXP |
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA] tocotrienol, delta results in decreased expression of VCAM1 mRNA |
CTD |
PMID:22185406 |
|
NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
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G |
Wnt1 |
wingless-type MMTV integration site family, member 1 |
decreases expression |
ISO |
tocotrienol, delta results in decreased expression of WNT1 protein |
CTD |
PMID:21453743 |
|
NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718
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G |
Abcc1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
decreases activity multiple interactions |
ISO |
Tocopherols results in decreased activity of ABCC1 protein Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide] |
CTD |
PMID:15617835 |
|
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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G |
Alb |
albumin |
multiple interactions |
ISO |
gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA] |
CTD |
PMID:19389874 |
|
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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G |
App |
amyloid beta (A4) precursor protein |
decreases abundance multiple interactions |
ISO |
APP protein modified form results in decreased abundance of Tocopherols resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols] |
CTD |
PMID:25654502 |
|
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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G |
Ar |
androgen receptor |
decreases activity decreases expression |
ISO |
Tocopherols results in decreased activity of AR protein [Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein |
CTD |
PMID:12032296 PMID:16302272 |
|
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
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|
G |
Arf3 |
ADP-ribosylation factor 3 |
increases expression |
EXP |
Tocopherols results in increased expression of ARF3 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
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G |
Aspm |
abnormal spindle microtubule assembly |
increases expression |
EXP |
Tocopherols results in increased expression of ASPM mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829
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|
G |
Atp1a2 |
ATPase, Na+/K+ transporting, alpha 2 polypeptide |
increases expression |
EXP |
Tocopherols results in increased expression of ATP1A2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
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|
G |
Atp1b2 |
ATPase, Na+/K+ transporting, beta 2 polypeptide |
increases expression |
EXP |
Tocopherols results in increased expression of ATP1B2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
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G |
Aurka |
aurora kinase A |
increases expression |
EXP |
Tocopherols results in increased expression of AURKA mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 2:172,198,110...172,212,820
Ensembl chr 2:172,198,110...172,212,455
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G |
Bax |
BCL2-associated X protein |
increases response to substance increases expression multiple interactions |
ISO |
BAX protein results in increased susceptibility to Tocopherols gamma-Tocopherol results in increased expression of BAX mRNA [Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNA |
CTD |
PMID:16001965 PMID:31587439 |
|
NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
increases expression multiple interactions decreases expression decreases response to substance |
EXP ISO |
Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of BCL2 mRNA gamma-Tocopherol results in decreased expression of BCL2 mRNA BCL2 protein results in decreased susceptibility to Tocopherols |
CTD |
PMID:8970189 PMID:16001965 PMID:31587439 |
|
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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|
G |
Bcl2l1 |
BCL2-like 1 |
decreases response to substance |
ISO |
BCL2L1 protein results in decreased susceptibility to Tocopherols |
CTD |
PMID:16001965 |
|
NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
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|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
EXP |
Tocopherols results in increased expression of BIRC5 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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|
G |
Camk2g |
calcium/calmodulin-dependent protein kinase II gamma |
increases expression |
EXP |
Tocopherols results in increased expression of CAMK2G mRNA |
CTD |
PMID:17654050 |
|
NCBI chr14:20,784,941...20,844,225
Ensembl chr14:20,784,943...20,844,156
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|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
gamma-Tocopherol results in increased activity of CASP3 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein] thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein] |
CTD |
PMID:15596715 PMID:22389237 |
|
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
|
|
G |
Casp9 |
caspase 9 |
increases activity |
ISO |
gamma-Tocopherol results in increased activity of CASP9 protein |
CTD |
PMID:15596715 |
|
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
|
|
G |
Cat |
catalase |
increases expression |
EXP |
gamma-Tocopherol results in increased expression of CAT protein |
CTD |
PMID:19115203 |
|
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
|
|
G |
Ccnb2 |
cyclin B2 |
increases expression |
EXP |
Tocopherols results in increased expression of CCNB2 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression multiple interactions |
ISO |
gamma-Tocopherol results in decreased expression of CCND1 mRNA; gamma-Tocopherol results in decreased expression of CCND1 protein; Tocopherols results in decreased expression of CCND1 protein [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCND1 mRNA |
CTD |
PMID:12368234 PMID:12504091 PMID:31587439 |
|
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
|
|
G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
Tocopherols results in decreased expression of CCND3 protein |
CTD |
PMID:12504091 |
|
NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
|
|
G |
Ccne1 |
cyclin E1 |
decreases expression multiple interactions |
ISO |
gamma-Tocopherol results in decreased expression of CCNE1 mRNA; gamma-Tocopherol results in decreased expression of CCNE1 protein; Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCNE1 mRNA |
CTD |
PMID:12368234 PMID:12504091 PMID:31587439 |
|
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
|
|
G |
Cdc6 |
cell division cycle 6 |
increases expression |
EXP |
Tocopherols results in increased expression of CDC6 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
EXP |
Tocopherols results in increased expression of CDK1 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
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G |
Cdk2 |
cyclin-dependent kinase 2 |
decreases expression |
ISO |
Tocopherols results in decreased expression of CDK2 protein |
CTD |
PMID:12504091 |
|
NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions |
ISO |
Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein |
CTD |
PMID:12504091 |
|
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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|
G |
Cdk5r1 |
cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
increases expression |
EXP |
Tocopherols results in increased expression of CDK5R1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A (P21) |
decreases expression |
ISO |
gamma-Tocopherol results in decreased expression of CDKN1A protein |
CTD |
PMID:12368234 |
|
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
gamma-Tocopherol results in decreased expression of CDKN1B protein |
CTD |
PMID:12368234 |
|
NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
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|
G |
Cdkn2a |
cyclin dependent kinase inhibitor 2A |
decreases expression |
ISO |
gamma-Tocopherol results in decreased expression of CDKN2A protein |
CTD |
PMID:12368234 |
|
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
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|
G |
Clec4e |
C-type lectin domain family 4, member e |
increases expression |
EXP |
Tocopherols results in increased expression of CLEC4E mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 6:123,258,748...123,266,830
Ensembl chr 6:123,258,748...123,266,829
|
|
G |
Cplx1 |
complexin 1 |
increases expression |
EXP |
Tocopherols results in increased expression of CPLX1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 5:108,666,420...108,697,893
Ensembl chr 5:108,666,420...108,697,890
|
|
G |
Cplx2 |
complexin 2 |
increases expression |
EXP |
Tocopherols results in increased expression of CPLX2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr13:54,455,447...54,531,736
Ensembl chr13:54,519,162...54,531,730
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|
G |
Crabp2 |
cellular retinoic acid binding protein II |
multiple interactions |
ISO |
[Tretinoin co-treated with gamma-Tocopherol] results in increased expression of CRABP2 mRNA |
CTD |
PMID:15225641 |
|
NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
|
|
G |
Crp |
C-reactive protein, pentraxin-related |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein |
CTD |
PMID:18191645 |
|
NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
|
|
G |
Csf1r |
colony stimulating factor 1 receptor |
increases expression |
EXP |
Tocopherols results in increased expression of CSF1R mRNA |
CTD |
PMID:17056531 |
|
NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
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|
G |
Csrp2 |
cysteine and glycine-rich protein 2 |
increases expression |
EXP |
Tocopherols results in increased expression of CSRP2 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA] |
CTD |
PMID:22389237 |
|
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
|
|
G |
Dnajc5 |
DnaJ heat shock protein family (Hsp40) member C5 |
increases expression |
EXP |
Tocopherols results in increased expression of DNAJC5 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:181,162,141...181,194,679
Ensembl chr 2:181,162,278...181,196,926
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|
G |
E2f1 |
E2F transcription factor 1 |
increases expression |
ISO |
Tocopherols results in increased expression of E2F1 protein |
CTD |
PMID:15883045 |
|
NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
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|
G |
Egr1 |
early growth response 1 |
decreases activity |
ISO |
Tocopherols results in decreased activity of EGR1 protein |
CTD |
PMID:15878867 |
|
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
|
|
G |
Esr1 |
estrogen receptor 1 (alpha) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] |
CTD |
PMID:22389237 |
|
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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|
G |
Esr2 |
estrogen receptor 2 (beta) |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] |
CTD |
PMID:22389237 |
|
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
|
|
G |
Fcer1a |
Fc receptor, IgE, high affinity I, alpha polypeptide |
increases expression |
EXP |
Tocopherols results in increased expression of FCER1A mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781
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|
G |
Fes |
feline sarcoma oncogene |
increases expression |
EXP |
Tocopherols results in increased expression of FES mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 7:80,027,506...80,037,702
Ensembl chr 7:80,027,504...80,037,694
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|
G |
Fgf1 |
fibroblast growth factor 1 |
decreases expression |
ISO |
Tocopherols results in decreased expression of FGF1 mRNA |
CTD |
PMID:15878867 |
|
NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
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|
G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression |
ISO |
Tocopherols results in decreased expression of FGF2 mRNA |
CTD |
PMID:15878867 |
|
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
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|
G |
Fgfr1 |
fibroblast growth factor receptor 1 |
decreases expression |
ISO |
Tocopherols results in decreased expression of FGFR1 mRNA |
CTD |
PMID:15144885 |
|
NCBI chr 8:26,008,775...26,065,734
Ensembl chr 8:26,003,670...26,065,734
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|
G |
Fkbp9 |
FK506 binding protein 9 |
increases expression |
EXP |
Tocopherols results in increased expression of FKBP9 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343
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G |
Fos |
FBJ osteosarcoma oncogene |
increases expression |
EXP |
Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein |
CTD |
PMID:8970189 |
|
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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G |
Fpr-rs4 |
formyl peptide receptor, related sequence 4 |
increases expression |
EXP |
Tocopherols results in increased expression of FPR-RS4 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr17:18,241,995...18,242,966
Ensembl chr17:18,241,995...18,242,966
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G |
Gclm |
glutamate-cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] |
CTD |
PMID:22389237 |
|
NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
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|
G |
Gria2 |
glutamate receptor, ionotropic, AMPA2 (alpha 2) |
increases expression |
EXP |
Tocopherols results in increased expression of GRIA2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142
|
|
G |
Grin1 |
glutamate receptor, ionotropic, NMDA1 (zeta 1) |
increases expression |
EXP |
Tocopherols results in increased expression of GRIN1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
|
|
G |
Gstm1 |
glutathione S-transferase, mu 1 |
increases expression multiple interactions |
EXP ISO |
gamma-Tocopherol results in increased expression of GSTM1 mRNA; gamma-Tocopherol results in increased expression of GSTM1 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] |
CTD |
PMID:19115203 PMID:22389237 |
|
NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
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|
G |
Gsto1 |
glutathione S-transferase omega 1 |
decreases activity |
ISO |
Tocopherols results in decreased activity of GSTO1 protein |
CTD |
PMID:16781109 |
|
NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
|
|
G |
Haspin |
histone H3 associated protein kinase |
increases expression |
EXP |
Tocopherols results in increased expression of HASPIN mRNA |
CTD |
PMID:17056531 |
|
NCBI chr11:73,026,310...73,029,120
Ensembl chr11:73,026,311...73,029,120
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP ISO |
gamma-Tocopherol results in increased expression of HMOX1 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein] |
CTD |
PMID:19115203 PMID:22389237 |
|
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
|
|
G |
Jun |
jun proto-oncogene |
increases expression |
EXP |
Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein |
CTD |
PMID:8970189 |
|
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
|
|
G |
Kif20a |
kinesin family member 20A |
increases expression |
EXP |
Tocopherols results in increased expression of KIF20A mRNA |
CTD |
PMID:17056531 |
|
NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
|
|
G |
Kif4 |
kinesin family member 4 |
increases expression |
EXP |
Tocopherols results in increased expression of KIF4 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr X:99,669,671...99,770,877
Ensembl chr X:99,669,343...99,770,820
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|
G |
Mcl1 |
myeloid cell leukemia sequence 1 |
decreases response to substance |
ISO |
MCL1 protein results in decreased susceptibility to Tocopherols |
CTD |
PMID:16001965 |
|
NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
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|
G |
Muc5ac |
mucin 5, subtypes A and C, tracheobronchial/gastric |
multiple interactions |
ISO |
gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA] |
CTD |
PMID:19389874 |
|
NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
|
|
G |
Myc |
myelocytomatosis oncogene |
decreases activity decreases expression |
EXP |
Tocopherols results in decreased activity of MYC protein Tocopherols results in decreased expression of MYC mRNA |
CTD |
PMID:8970189 |
|
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
|
|
G |
Napb |
N-ethylmaleimide sensitive fusion protein attachment protein beta |
increases expression |
EXP |
Tocopherols results in increased expression of NAPB mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:148,535,905...148,574,396
Ensembl chr 2:148,535,905...148,574,387
|
|
G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
increases expression multiple interactions |
EXP ISO |
gamma-Tocopherol results in increased expression of NFE2L2 mRNA; gamma-Tocopherol results in increased expression of NFE2L2 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein] |
CTD |
PMID:19115203 PMID:22389237 |
|
NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
|
|
G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] |
CTD |
PMID:22389237 |
|
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
|
|
G |
Nsf |
N-ethylmaleimide sensitive fusion protein |
increases expression |
EXP |
Tocopherols results in increased expression of NSF mRNA |
CTD |
PMID:17654050 |
|
NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions decreases expression |
ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] Tocopherols results in decreased expression of PCNA |
CTD |
PMID:17927505 PMID:22389237 |
|
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
|
|
G |
Pparg |
peroxisome proliferator activated receptor gamma |
increases expression multiple interactions |
ISO |
gamma-Tocopherol results in increased expression of PPARG mRNA; gamma-Tocopherol results in increased expression of PPARG protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein] |
CTD |
PMID:14521714 PMID:22389237 |
|
NCBI chr 6:115,337,840...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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G |
Ppp3ca |
protein phosphatase 3, catalytic subunit, alpha isoform |
increases expression |
EXP |
Tocopherols results in increased expression of PPP3CA mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
|
|
G |
Prtn3 |
proteinase 3 |
increases expression |
EXP |
Tocopherols results in increased expression of PRTN3 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr10:79,715,501...79,719,008
Ensembl chr10:79,710,310...79,719,008
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases activity multiple interactions |
ISO |
gamma-Tocopherol results in decreased activity of PTGS2 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein] |
CTD |
PMID:15225597 PMID:22389237 |
|
NCBI chr 1:149,975,782...149,983,985
Ensembl chr 1:149,975,782...149,983,978
|
|
G |
Ptpro |
protein tyrosine phosphatase, receptor type, O |
increases expression |
EXP |
Tocopherols results in increased expression of PTPRO mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 6:137,229,189...137,441,632
Ensembl chr 6:137,229,317...137,440,231
|
|
G |
Rab11b |
RAB11B, member RAS oncogene family |
increases expression |
EXP |
Tocopherols results in increased expression of RAB11B mRNA |
CTD |
PMID:17654050 |
|
NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504
|
|
G |
Rab3a |
RAB3A, member RAS oncogene family |
increases expression |
EXP |
Tocopherols results in increased expression of RAB3A mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
|
|
G |
Rab6b |
RAB6B, member RAS oncogene family |
increases expression |
EXP |
Tocopherols results in increased expression of RAB6B mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 9:102,988,866...103,062,475
Ensembl chr 9:102,988,986...103,062,475
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|
G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
Tocopherols results in decreased phosphorylation of RB1 protein |
CTD |
PMID:12504091 |
|
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
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|
G |
Rrm1 |
ribonucleotide reductase M1 |
increases expression |
EXP |
Tocopherols results in increased expression of RRM1 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978
|
|
G |
Rrm2 |
ribonucleotide reductase M2 |
increases expression |
EXP |
Tocopherols results in increased expression of RRM2 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
|
|
G |
Snca |
synuclein, alpha |
increases expression |
EXP |
Tocopherols results in increased expression of SNCA mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
|
|
G |
Sncb |
synuclein, beta |
increases expression |
EXP |
Tocopherols results in increased expression of SNCB mRNA |
CTD |
PMID:17654050 |
|
NCBI chr13:54,906,673...54,914,435
Ensembl chr13:54,906,673...54,914,408
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|
G |
Sod1 |
superoxide dismutase 1, soluble |
increases expression |
EXP |
gamma-Tocopherol results in increased expression of SOD1 protein |
CTD |
PMID:19115203 |
|
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
|
|
G |
Stx1a |
syntaxin 1A (brain) |
increases expression |
EXP |
Tocopherols results in increased expression of STX1A mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
|
|
G |
Stxbp1 |
syntaxin binding protein 1 |
increases expression |
EXP |
Tocopherols results in increased expression of STXBP1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
|
|
G |
Sv2a |
synaptic vesicle glycoprotein 2 a |
increases expression |
EXP |
Tocopherols results in increased expression of SV2A mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 3:96,088,543...96,102,499
Ensembl chr 3:96,088,467...96,102,837
|
|
G |
Syn1 |
synapsin I |
increases expression |
EXP |
Tocopherols results in increased expression of SYN1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr X:20,726,750...20,787,157
Ensembl chr X:20,726,750...20,787,243
|
|
G |
Syn2 |
synapsin II |
increases expression |
EXP |
Tocopherols results in increased expression of SYN2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967
|
|
G |
Syngr1 |
synaptogyrin 1 |
increases expression |
EXP |
Tocopherols results in increased expression of SYNGR1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr15:79,975,535...80,003,702
Ensembl chr15:79,975,535...80,003,702
|
|
G |
Syp |
synaptophysin |
increases expression |
EXP |
Tocopherols results in increased expression of SYP mRNA |
CTD |
PMID:17654050 |
|
NCBI chr X:7,504,819...7,519,495
Ensembl chr X:7,504,710...7,519,495
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G |
Syt11 |
synaptotagmin XI |
increases expression |
EXP |
Tocopherols results in increased expression of SYT11 mRNA |
CTD |
PMID:17654050 |
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NCBI chr 3:88,652,006...88,682,466
Ensembl chr 3:88,652,007...88,682,471
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G |
Syt13 |
synaptotagmin XIII |
increases expression |
EXP |
Tocopherols results in increased expression of SYT13 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:92,745,446...92,786,396
Ensembl chr 2:92,745,443...92,786,403
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium] |
CTD |
PMID:17337591 PMID:18191645 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Tnfaip2 |
tumor necrosis factor, alpha-induced protein 2 |
increases expression |
EXP |
Tocopherols results in increased expression of TNFAIP2 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452
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G |
Trp53 |
transformation related protein 53 |
increases activity |
ISO |
Tocopherols results in increased activity of TP53 protein |
CTD |
PMID:15883045 |
|
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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G |
Ttc3 |
tetratricopeptide repeat domain 3 |
increases expression |
EXP |
Tocopherols results in increased expression of TTC3 mRNA |
CTD |
PMID:17654050 |
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NCBI chr16:94,171,479...94,270,081
Ensembl chr16:94,171,477...94,270,202
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
increases expression multiple interactions |
EXP ISO |
gamma-Tocopherol results in increased expression of UGT1A1 mRNA [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] |
CTD |
PMID:19115203 PMID:22389237 |
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NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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G |
Vamp1 |
vesicle-associated membrane protein 1 |
increases expression |
EXP |
Tocopherols results in increased expression of VAMP1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927
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G |
Vamp2 |
vesicle-associated membrane protein 2 |
increases expression |
EXP |
Tocopherols results in increased expression of VAMP2 mRNA |
CTD |
PMID:17654050 |
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NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
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G |
Vdr |
vitamin D (1,25-dihydroxyvitamin D3) receptor |
increases expression |
ISO |
Tocopherols results in increased expression of VDR mRNA |
CTD |
PMID:12032296 |
|
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
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G |
Abcc1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
multiple interactions decreases activity |
ISO |
Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide] Tocopherols results in decreased activity of ABCC1 protein |
CTD |
PMID:15617835 |
|
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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G |
App |
amyloid beta (A4) precursor protein |
multiple interactions decreases abundance |
ISO |
resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols] |
CTD |
PMID:25654502 |
|
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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G |
Ar |
androgen receptor |
decreases activity decreases expression |
ISO |
Tocopherols results in decreased activity of AR protein [Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein |
CTD |
PMID:12032296 PMID:16302272 |
|
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
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G |
Arf3 |
ADP-ribosylation factor 3 |
increases expression |
EXP |
Tocopherols results in increased expression of ARF3 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
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G |
Aspm |
abnormal spindle microtubule assembly |
increases expression |
EXP |
Tocopherols results in increased expression of ASPM mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829
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G |
Atp1a2 |
ATPase, Na+/K+ transporting, alpha 2 polypeptide |
increases expression |
EXP |
Tocopherols results in increased expression of ATP1A2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
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G |
Atp1b2 |
ATPase, Na+/K+ transporting, beta 2 polypeptide |
increases expression |
EXP |
Tocopherols results in increased expression of ATP1B2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
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G |
Aurka |
aurora kinase A |
increases expression |
EXP |
Tocopherols results in increased expression of AURKA mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 2:172,198,110...172,212,820
Ensembl chr 2:172,198,110...172,212,455
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G |
Bax |
BCL2-associated X protein |
increases response to substance |
ISO |
BAX protein results in increased susceptibility to Tocopherols |
CTD |
PMID:16001965 |
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NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
decreases response to substance increases expression |
ISO EXP |
BCL2 protein results in decreased susceptibility to Tocopherols Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein |
CTD |
PMID:8970189 PMID:16001965 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Bcl2l1 |
BCL2-like 1 |
decreases response to substance |
ISO |
BCL2L1 protein results in decreased susceptibility to Tocopherols |
CTD |
PMID:16001965 |
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NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
EXP |
Tocopherols results in increased expression of BIRC5 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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G |
Camk2g |
calcium/calmodulin-dependent protein kinase II gamma |
increases expression |
EXP |
Tocopherols results in increased expression of CAMK2G mRNA |
CTD |
PMID:17654050 |
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NCBI chr14:20,784,941...20,844,225
Ensembl chr14:20,784,943...20,844,156
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G |
Ccnb2 |
cyclin B2 |
increases expression |
EXP |
Tocopherols results in increased expression of CCNB2 mRNA |
CTD |
PMID:17056531 |
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NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Tocopherols results in decreased expression of CCND1 protein |
CTD |
PMID:12504091 |
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NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
Tocopherols results in decreased expression of CCND3 protein |
CTD |
PMID:12504091 |
|
NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein |
CTD |
PMID:12504091 |
|
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
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G |
Cdc6 |
cell division cycle 6 |
increases expression |
EXP |
Tocopherols results in increased expression of CDC6 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
EXP |
Tocopherols results in increased expression of CDK1 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
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G |
Cdk2 |
cyclin-dependent kinase 2 |
decreases expression |
ISO |
Tocopherols results in decreased expression of CDK2 protein |
CTD |
PMID:12504091 |
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NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions |
ISO |
Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein |
CTD |
PMID:12504091 |
|
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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G |
Cdk5r1 |
cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
increases expression |
EXP |
Tocopherols results in increased expression of CDK5R1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010
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G |
Clec4e |
C-type lectin domain family 4, member e |
increases expression |
EXP |
Tocopherols results in increased expression of CLEC4E mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 6:123,258,748...123,266,830
Ensembl chr 6:123,258,748...123,266,829
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G |
Cplx1 |
complexin 1 |
increases expression |
EXP |
Tocopherols results in increased expression of CPLX1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 5:108,666,420...108,697,893
Ensembl chr 5:108,666,420...108,697,890
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G |
Cplx2 |
complexin 2 |
increases expression |
EXP |
Tocopherols results in increased expression of CPLX2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr13:54,455,447...54,531,736
Ensembl chr13:54,519,162...54,531,730
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G |
Csf1r |
colony stimulating factor 1 receptor |
increases expression |
EXP |
Tocopherols results in increased expression of CSF1R mRNA |
CTD |
PMID:17056531 |
|
NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
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G |
Csrp2 |
cysteine and glycine-rich protein 2 |
increases expression |
EXP |
Tocopherols results in increased expression of CSRP2 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483
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G |
Dnajc5 |
DnaJ heat shock protein family (Hsp40) member C5 |
increases expression |
EXP |
Tocopherols results in increased expression of DNAJC5 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:181,162,141...181,194,679
Ensembl chr 2:181,162,278...181,196,926
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G |
E2f1 |
E2F transcription factor 1 |
increases expression |
ISO |
Tocopherols results in increased expression of E2F1 protein |
CTD |
PMID:15883045 |
|
NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
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G |
Egr1 |
early growth response 1 |
decreases activity |
ISO |
Tocopherols results in decreased activity of EGR1 protein |
CTD |
PMID:15878867 |
|
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
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G |
Fcer1a |
Fc receptor, IgE, high affinity I, alpha polypeptide |
increases expression |
EXP |
Tocopherols results in increased expression of FCER1A mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781
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G |
Fes |
feline sarcoma oncogene |
increases expression |
EXP |
Tocopherols results in increased expression of FES mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 7:80,027,506...80,037,702
Ensembl chr 7:80,027,504...80,037,694
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G |
Fgf1 |
fibroblast growth factor 1 |
decreases expression |
ISO |
Tocopherols results in decreased expression of FGF1 mRNA |
CTD |
PMID:15878867 |
|
NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression |
ISO |
Tocopherols results in decreased expression of FGF2 mRNA |
CTD |
PMID:15878867 |
|
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
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G |
Fgfr1 |
fibroblast growth factor receptor 1 |
decreases expression |
ISO |
Tocopherols results in decreased expression of FGFR1 mRNA |
CTD |
PMID:15144885 |
|
NCBI chr 8:26,008,775...26,065,734
Ensembl chr 8:26,003,670...26,065,734
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G |
Fkbp9 |
FK506 binding protein 9 |
increases expression |
EXP |
Tocopherols results in increased expression of FKBP9 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343
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G |
Fos |
FBJ osteosarcoma oncogene |
increases expression |
EXP |
Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein |
CTD |
PMID:8970189 |
|
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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G |
Fpr-rs4 |
formyl peptide receptor, related sequence 4 |
increases expression |
EXP |
Tocopherols results in increased expression of FPR-RS4 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr17:18,241,995...18,242,966
Ensembl chr17:18,241,995...18,242,966
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G |
Gria2 |
glutamate receptor, ionotropic, AMPA2 (alpha 2) |
increases expression |
EXP |
Tocopherols results in increased expression of GRIA2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142
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G |
Grin1 |
glutamate receptor, ionotropic, NMDA1 (zeta 1) |
increases expression |
EXP |
Tocopherols results in increased expression of GRIN1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
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G |
Gsto1 |
glutathione S-transferase omega 1 |
decreases activity |
ISO |
Tocopherols results in decreased activity of GSTO1 protein |
CTD |
PMID:16781109 |
|
NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
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G |
Haspin |
histone H3 associated protein kinase |
increases expression |
EXP |
Tocopherols results in increased expression of HASPIN mRNA |
CTD |
PMID:17056531 |
|
NCBI chr11:73,026,310...73,029,120
Ensembl chr11:73,026,311...73,029,120
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G |
Jun |
jun proto-oncogene |
increases expression |
EXP |
Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein |
CTD |
PMID:8970189 |
|
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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G |
Kif20a |
kinesin family member 20A |
increases expression |
EXP |
Tocopherols results in increased expression of KIF20A mRNA |
CTD |
PMID:17056531 |
|
NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
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G |
Kif4 |
kinesin family member 4 |
increases expression |
EXP |
Tocopherols results in increased expression of KIF4 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr X:99,669,671...99,770,877
Ensembl chr X:99,669,343...99,770,820
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G |
Mcl1 |
myeloid cell leukemia sequence 1 |
decreases response to substance |
ISO |
MCL1 protein results in decreased susceptibility to Tocopherols |
CTD |
PMID:16001965 |
|
NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
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G |
Myc |
myelocytomatosis oncogene |
decreases activity decreases expression |
EXP |
Tocopherols results in decreased activity of MYC protein Tocopherols results in decreased expression of MYC mRNA |
CTD |
PMID:8970189 |
|
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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G |
Napb |
N-ethylmaleimide sensitive fusion protein attachment protein beta |
increases expression |
EXP |
Tocopherols results in increased expression of NAPB mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:148,535,905...148,574,396
Ensembl chr 2:148,535,905...148,574,387
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G |
Nsf |
N-ethylmaleimide sensitive fusion protein |
increases expression |
EXP |
Tocopherols results in increased expression of NSF mRNA |
CTD |
PMID:17654050 |
|
NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
Tocopherols results in decreased expression of PCNA |
CTD |
PMID:17927505 |
|
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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G |
Ppp3ca |
protein phosphatase 3, catalytic subunit, alpha isoform |
increases expression |
EXP |
Tocopherols results in increased expression of PPP3CA mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
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G |
Prtn3 |
proteinase 3 |
increases expression |
EXP |
Tocopherols results in increased expression of PRTN3 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr10:79,715,501...79,719,008
Ensembl chr10:79,710,310...79,719,008
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G |
Ptpro |
protein tyrosine phosphatase, receptor type, O |
increases expression |
EXP |
Tocopherols results in increased expression of PTPRO mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 6:137,229,189...137,441,632
Ensembl chr 6:137,229,317...137,440,231
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G |
Rab11b |
RAB11B, member RAS oncogene family |
increases expression |
EXP |
Tocopherols results in increased expression of RAB11B mRNA |
CTD |
PMID:17654050 |
|
NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504
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G |
Rab3a |
RAB3A, member RAS oncogene family |
increases expression |
EXP |
Tocopherols results in increased expression of RAB3A mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
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G |
Rab6b |
RAB6B, member RAS oncogene family |
increases expression |
EXP |
Tocopherols results in increased expression of RAB6B mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 9:102,988,866...103,062,475
Ensembl chr 9:102,988,986...103,062,475
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
Tocopherols results in decreased phosphorylation of RB1 protein |
CTD |
PMID:12504091 |
|
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
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G |
Rrm1 |
ribonucleotide reductase M1 |
increases expression |
EXP |
Tocopherols results in increased expression of RRM1 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978
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G |
Rrm2 |
ribonucleotide reductase M2 |
increases expression |
EXP |
Tocopherols results in increased expression of RRM2 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
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G |
Snca |
synuclein, alpha |
increases expression |
EXP |
Tocopherols results in increased expression of SNCA mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
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G |
Sncb |
synuclein, beta |
increases expression |
EXP |
Tocopherols results in increased expression of SNCB mRNA |
CTD |
PMID:17654050 |
|
NCBI chr13:54,906,673...54,914,435
Ensembl chr13:54,906,673...54,914,408
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G |
Stx1a |
syntaxin 1A (brain) |
increases expression |
EXP |
Tocopherols results in increased expression of STX1A mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
|
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G |
Stxbp1 |
syntaxin binding protein 1 |
increases expression |
EXP |
Tocopherols results in increased expression of STXBP1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
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Sv2a |
synaptic vesicle glycoprotein 2 a |
increases expression |
EXP |
Tocopherols results in increased expression of SV2A mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 3:96,088,543...96,102,499
Ensembl chr 3:96,088,467...96,102,837
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G |
Syn1 |
synapsin I |
increases expression |
EXP |
Tocopherols results in increased expression of SYN1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr X:20,726,750...20,787,157
Ensembl chr X:20,726,750...20,787,243
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G |
Syn2 |
synapsin II |
increases expression |
EXP |
Tocopherols results in increased expression of SYN2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967
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G |
Syngr1 |
synaptogyrin 1 |
increases expression |
EXP |
Tocopherols results in increased expression of SYNGR1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr15:79,975,535...80,003,702
Ensembl chr15:79,975,535...80,003,702
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G |
Syp |
synaptophysin |
increases expression |
EXP |
Tocopherols results in increased expression of SYP mRNA |
CTD |
PMID:17654050 |
|
NCBI chr X:7,504,819...7,519,495
Ensembl chr X:7,504,710...7,519,495
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G |
Syt11 |
synaptotagmin XI |
increases expression |
EXP |
Tocopherols results in increased expression of SYT11 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 3:88,652,006...88,682,466
Ensembl chr 3:88,652,007...88,682,471
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G |
Syt13 |
synaptotagmin XIII |
increases expression |
EXP |
Tocopherols results in increased expression of SYT13 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 2:92,745,446...92,786,396
Ensembl chr 2:92,745,443...92,786,403
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium] |
CTD |
PMID:17337591 |
|
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Tnfaip2 |
tumor necrosis factor, alpha-induced protein 2 |
increases expression |
EXP |
Tocopherols results in increased expression of TNFAIP2 mRNA |
CTD |
PMID:17056531 |
|
NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452
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G |
Trp53 |
transformation related protein 53 |
increases activity |
ISO |
Tocopherols results in increased activity of TP53 protein |
CTD |
PMID:15883045 |
|
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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|
G |
Ttc3 |
tetratricopeptide repeat domain 3 |
increases expression |
EXP |
Tocopherols results in increased expression of TTC3 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr16:94,171,479...94,270,081
Ensembl chr16:94,171,477...94,270,202
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|
G |
Vamp1 |
vesicle-associated membrane protein 1 |
increases expression |
EXP |
Tocopherols results in increased expression of VAMP1 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927
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|
G |
Vamp2 |
vesicle-associated membrane protein 2 |
increases expression |
EXP |
Tocopherols results in increased expression of VAMP2 mRNA |
CTD |
PMID:17654050 |
|
NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
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|
G |
Vdr |
vitamin D (1,25-dihydroxyvitamin D3) receptor |
increases expression |
ISO |
Tocopherols results in increased expression of VDR mRNA |
CTD |
PMID:12032296 |
|
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
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|
G |
Abcb1a |
ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
multiple interactions |
ISO |
[methoxy poly(ethylene glycol-co-epsilon-caprolactone) co-treated with tocophersolan co-treated with Resveratrol] results in decreased expression of ABCB1 protein |
CTD |
PMID:25392124 |
|
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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|
G |
1110038F14Rik |
RIKEN cDNA 1110038F14 gene |
increases expression |
ISO |
Vitamin E results in increased expression of C8ORF33 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:76,832,453...76,835,179
Ensembl chr15:76,832,706...76,835,179
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G |
1700037H04Rik |
RIKEN cDNA 1700037H04 gene |
increases expression multiple interactions |
ISO |
Vitamin E results in increased expression of C20ORF27 mRNA [Selenium co-treated with Vitamin E] results in decreased expression of C20ORF27 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:130,988,235...131,002,001
Ensembl chr 2:130,988,244...131,002,001
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|
G |
2610507B11Rik |
RIKEN cDNA 2610507B11 gene |
increases expression |
ISO |
Vitamin E results in increased expression of KIAA0100 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr11:78,152,476...78,181,451
Ensembl chr11:78,152,578...78,181,449
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|
G |
5031439G07Rik |
RIKEN cDNA 5031439G07 gene |
increases expression |
ISO |
Vitamin E results in increased expression of KIAA0930 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:84,828,137...84,872,503
Ensembl chr15:84,828,137...84,872,752
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G |
5730409E04Rik |
RIKEN cDNA 5730409E04Rik gene |
increases expression |
ISO |
Vitamin E results in increased expression of C1ORF216 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 4:126,503,647...126,508,164
Ensembl chr 4:126,503,611...126,508,164
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G |
Aamp |
angio-associated migratory protein |
increases expression |
ISO |
Vitamin E results in increased expression of AAMP mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 1:74,318,999...74,324,833
Ensembl chr 1:74,318,999...74,323,897
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G |
Aass |
aminoadipate-semialdehyde synthase |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of AASS mRNA Vitamin E results in decreased expression of AASS mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 6:23,072,172...23,132,985
Ensembl chr 6:23,072,172...23,132,985
|
|
G |
Abcc2 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
multiple interactions |
ISO |
[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of ABCC2 mRNA |
CTD |
PMID:11444866 |
|
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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G |
Abhd14a |
abhydrolase domain containing 14A |
decreases expression |
ISO |
Vitamin E results in decreased expression of ABHD14A mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 9:106,317,250...106,328,402
Ensembl chr 9:106,317,250...106,324,877
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G |
Abhd2 |
abhydrolase domain containing 2 |
decreases expression increases expression |
ISO |
Vitamin E results in decreased expression of ABHD2 mRNA Vitamin E results in increased expression of ABHD2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:78,923,002...79,015,257
Ensembl chr 7:78,922,947...79,015,256
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G |
Abhd4 |
abhydrolase domain containing 4 |
increases expression |
ISO |
Vitamin E results in increased expression of ABHD4 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr14:54,491,586...54,506,626
Ensembl chr14:54,491,645...54,508,094
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G |
Acaa2 |
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) |
increases expression |
ISO |
Vitamin E results in increased expression of ACAA2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
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G |
Acads |
acyl-Coenzyme A dehydrogenase, short chain |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of ACADS mRNA Vitamin E results in increased expression of ACADS mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405
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|
G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP ISO |
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein] [Zinc co-treated with Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [sodium arsenite results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein] |
CTD |
PMID:11814146 PMID:20663516 PMID:23619517 PMID:29233033 |
|
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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G |
Aco2 |
aconitase 2, mitochondrial |
increases expression |
ISO |
Vitamin E results in increased expression of ACO2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
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|
G |
Acot2 |
acyl-CoA thioesterase 2 |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of ACOT2 mRNA Vitamin E results in increased expression of ACOT2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647
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|
G |
Acp1 |
acid phosphatase 1, soluble |
decreases expression |
ISO |
Vitamin E results in decreased expression of ACP1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588
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G |
Acta2 |
actin alpha 2, smooth muscle, aorta |
decreases expression |
ISO |
Vitamin E results in decreased expression of ACTA2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
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G |
Actb |
actin, beta |
increases expression |
ISO |
Vitamin E results in increased expression of ACTB mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
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|
G |
Actn4 |
actinin alpha 4 |
increases expression |
ISO |
Vitamin E results in increased expression of ACTN4 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765
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|
G |
Actr1a |
ARP1 actin-related protein 1A, centractin alpha |
increases expression |
ISO |
Vitamin E results in increased expression of ACTR1A mRNA |
CTD |
PMID:19244175 |
|
NCBI chr19:46,365,252...46,384,180
Ensembl chr19:46,365,250...46,384,187
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|
G |
Actr1b |
ARP1 actin-related protein 1B, centractin beta |
increases expression |
ISO |
Vitamin E results in increased expression of ACTR1B mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 1:36,737,195...36,749,081
Ensembl chr 1:36,737,195...36,753,503
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|
G |
Acvr2a |
activin receptor IIA |
decreases expression |
ISO |
Vitamin E results in decreased expression of ACVR2A mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:48,704,121...48,793,276
Ensembl chr 2:48,704,121...48,793,281
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|
G |
Adam17 |
a disintegrin and metallopeptidase domain 17 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ADAM17 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633
|
|
G |
Adamts5 |
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) |
decreases expression |
ISO |
Vitamin E results in decreased expression of ADAMTS5 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr16:85,655,045...85,698,013
Ensembl chr16:85,653,061...85,698,716
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G |
Adap1 |
ArfGAP with dual PH domains 1 |
increases expression |
ISO |
Vitamin E results in increased expression of ADAP1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:139,257,631...139,311,516
Ensembl chr 5:139,257,631...139,311,377
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|
G |
Adarb1 |
adenosine deaminase, RNA-specific, B1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ADARB1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr10:77,126,561...77,254,125
Ensembl chr10:77,126,560...77,254,104
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|
G |
Adcy2 |
adenylate cyclase 2 |
multiple interactions |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of ADCY2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660
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G |
Adcy6 |
adenylate cyclase 6 |
increases expression |
ISO |
Vitamin E results in increased expression of ADCY6 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:98,484,982...98,508,173
Ensembl chr15:98,487,854...98,507,957
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G |
Add1 |
adducin 1 (alpha) |
increases expression |
ISO |
Vitamin E results in increased expression of ADD1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:34,731,008...34,789,652
Ensembl chr 5:34,731,008...34,789,652
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G |
Add3 |
adducin 3 (gamma) |
decreases expression |
ISO |
Vitamin E results in decreased expression of ADD3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr19:53,128,874...53,235,757
Ensembl chr19:53,128,874...53,235,830
|
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G |
Adgrb1 |
adhesion G protein-coupled receptor B1 |
increases expression |
ISO |
Vitamin E results in increased expression of ADGRB1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:74,388,045...74,461,314
Ensembl chr15:74,388,044...74,461,314
|
|
G |
Adh7 |
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
decreases expression |
ISO |
Vitamin E results in decreased expression of ADH7 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] |
CTD |
PMID:20404018 |
|
NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
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G |
Adra2c |
adrenergic receptor, alpha 2c |
increases expression |
ISO |
Vitamin E results in increased expression of ADRA2C mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:35,435,910...35,439,107
Ensembl chr 5:35,435,663...35,439,107
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G |
Adrm1 |
adhesion regulating molecule 1 |
increases expression |
ISO |
Vitamin E results in increased expression of ADRM1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:179,813,381...179,818,076
Ensembl chr 2:179,813,278...179,818,079
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G |
Aebp1 |
AE binding protein 1 |
increases expression |
ISO |
Vitamin E results in increased expression of AEBP1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr11:5,806,085...5,822,248
Ensembl chr11:5,811,947...5,822,088
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G |
Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
Vitamin E results in increased expression of AEN mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957
|
|
G |
Agpat2 |
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) |
multiple interactions |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of AGPAT2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:26,483,069...26,494,429
Ensembl chr 2:26,483,069...26,494,429
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G |
Agrn |
agrin |
decreases expression |
ISO |
Vitamin E results in decreased expression of AGRN mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945
|
|
G |
Agtpbp1 |
ATP/GTP binding protein 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of AGTPBP1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr13:59,597,348...59,705,184
Ensembl chr13:59,593,556...59,733,041
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G |
Ahnak |
AHNAK nucleoprotein (desmoyokin) |
increases expression |
ISO |
Vitamin E results in increased expression of AHNAK mRNA |
CTD |
PMID:19244175 |
|
NCBI chr19:8,966,640...9,054,299
Ensembl chr19:8,966,648...9,054,278
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G |
Ahnak2 |
AHNAK nucleoprotein 2 |
increases expression |
ISO |
Vitamin E results in increased expression of AHNAK2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:112,738,631...112,766,278
Ensembl chr12:112,738,628...112,766,277
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G |
Ahr |
aryl-hydrocarbon receptor |
decreases expression |
ISO |
Vitamin E results in decreased expression of AHR mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
|
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G |
Ahsa1 |
AHA1, activator of heat shock protein ATPase 1 |
increases expression |
ISO |
Vitamin E results in increased expression of AHSA1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:87,313,189...87,320,772
Ensembl chr12:87,313,253...87,320,772
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|
G |
AI837181 |
expressed sequence AI837181 |
increases expression |
ISO |
Vitamin E results in increased expression of C11ORF68 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr19:5,475,172...5,477,345
Ensembl chr19:5,475,172...5,477,341
|
|
G |
Aimp1 |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of AIMP1 mRNA Vitamin E results in decreased expression of AIMP1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 3:132,366,259...132,390,151
Ensembl chr 3:132,366,242...132,390,131
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|
G |
Ak1 |
adenylate kinase 1 |
increases expression |
ISO |
Vitamin E results in increased expression of AK1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070
|
|
G |
Ak3 |
adenylate kinase 3 |
multiple interactions |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of AK3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361
|
|
G |
Akap13 |
A kinase (PRKA) anchor protein 13 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of AKAP13 mRNA Vitamin E results in decreased expression of AKAP13 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357
|
|
G |
Akr1b3 |
aldo-keto reductase family 1, member B3 (aldose reductase) |
increases expression |
ISO |
Vitamin E results in increased expression of AKR1B1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
|
|
G |
Akr1c21 |
aldo-keto reductase family 1, member C21 |
increases expression |
ISO |
Vitamin E results in increased expression of AKR1C2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
|
|
G |
Akt1 |
thymoma viral proto-oncogene 1 |
increases expression multiple interactions |
ISO |
Vitamin E results in increased expression of AKT1 mRNA [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:19244175 PMID:21911000 |
|
NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
|
|
G |
Alad |
aminolevulinate, delta-, dehydratase |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [lead acetate results in decreased activity of ALAD protein] |
CTD |
PMID:2604901 |
|
NCBI chr 4:62,424,221...62,438,300
Ensembl chr 4:62,427,406...62,438,155
|
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G |
Alb |
albumin |
multiple interactions |
EXP ISO |
Vitamin E inhibits the reaction [Ethanol results in decreased expression of ALB protein] [Quercetin co-treated with Vitamin E] inhibits the reaction [Cyclosporine results in decreased expression of ALB protein]; Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of ALB protein] Vitamin E inhibits the reaction [Oleic Acid results in decreased secretion of ALB protein] |
CTD |
PMID:17927767 PMID:21086752 PMID:23348005 |
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NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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G |
Aldh6a1 |
aldehyde dehydrogenase family 6, subfamily A1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ALDH6A1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:84,477,491...84,497,798
Ensembl chr12:84,477,491...84,497,778
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G |
Alg3 |
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase) |
increases expression |
ISO |
Vitamin E results in increased expression of ALG3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr16:20,424,208...20,429,515
Ensembl chr16:20,424,124...20,430,485
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G |
Alg9 |
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase) |
multiple interactions |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of ALG9 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 9:50,686,525...50,754,939
Ensembl chr 9:50,686,319...50,754,842
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G |
Alkbh1 |
alkB homolog 1, histone H2A dioxygenase |
decreases expression |
ISO |
Vitamin E results in decreased expression of ALKBH1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:87,474,847...87,490,609
Ensembl chr12:87,472,610...87,490,787
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G |
Alox5 |
arachidonate 5-lipoxygenase |
decreases activity multiple interactions |
ISO |
Vitamin E results in decreased activity of ALOX5 protein [Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 mRNA; [Vitamin E co-treated with Selenium] results in decreased expression of ALOX5 protein |
CTD |
PMID:11325678 PMID:12200813 PMID:22223226 |
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NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
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G |
Alpl |
alkaline phosphatase, liver/bone/kidney |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [Doxorubicin results in decreased activity of ALPL protein] |
CTD |
PMID:32810592 |
|
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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G |
Ambra1 |
autophagy/beclin 1 regulator 1 |
increases expression |
ISO |
Vitamin E results in increased expression of AMBRA1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:91,560,464...91,749,194
Ensembl chr 2:91,560,479...91,749,194
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G |
Amy1 |
amylase 1, salivary |
decreases expression |
ISO |
Vitamin E results in decreased expression of AMY2A mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 3:113,349,601...113,371,399
Ensembl chr 3:113,349,359...113,400,348
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G |
Anapc15 |
anaphase promoting complex C subunit 15 |
increases expression |
ISO |
Vitamin E results in increased expression of ANAPC15 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:101,530,508...101,551,056
Ensembl chr 7:101,512,922...101,551,056
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G |
Angpt1 |
angiopoietin 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ANGPT1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373
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G |
Ank3 |
ankyrin 3, epithelial |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of ANK3 mRNA Vitamin E results in decreased expression of ANK3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268
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G |
Ankrd12 |
ankyrin repeat domain 12 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ANKRD12 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr17:66,272,698...66,386,242
Ensembl chr17:66,272,693...66,384,084
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G |
Anp32b |
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of ANP32B mRNA Vitamin E results in decreased expression of ANP32B mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 4:46,450,926...46,472,657
Ensembl chr 4:46,450,902...46,472,657
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G |
Anxa6 |
annexin A6 |
increases expression |
ISO |
Vitamin E results in increased expression of ANXA6 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr11:54,869,779...54,924,297
Ensembl chr11:54,869,934...54,924,271
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G |
Ap1m2 |
adaptor protein complex AP-1, mu 2 subunit |
increases expression |
ISO |
Vitamin E results in increased expression of AP1M2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 9:21,205,911...21,223,645
Ensembl chr 9:21,205,571...21,223,633
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G |
Ap2a2 |
adaptor-related protein complex 2, alpha 2 subunit |
increases expression |
ISO |
Vitamin E results in increased expression of AP2A2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:141,142,093...141,212,924
Ensembl chr 7:141,142,086...141,212,924
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G |
Ap2m1 |
adaptor-related protein complex 2, mu 1 subunit |
increases expression |
ISO |
Vitamin E results in increased expression of AP2M1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr16:20,354,230...20,363,659
Ensembl chr16:20,354,228...20,363,659
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G |
Ap2s1 |
adaptor-related protein complex 2, sigma 1 subunit |
increases expression |
ISO |
Vitamin E results in increased expression of AP2S1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:16,472,369...16,483,215
Ensembl chr 7:16,472,335...16,483,219
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G |
Ap3s2 |
adaptor-related protein complex 3, sigma 2 subunit |
increases expression |
ISO |
Vitamin E results in increased expression of AP3S2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:79,525,073...79,570,388
Ensembl chr 7:79,525,073...79,570,397
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G |
Apbb2 |
amyloid beta (A4) precursor protein-binding, family B, member 2 |
decreases expression |
ISO |
Vitamin E results in decreased expression of APBB2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:66,456,068...66,779,189
Ensembl chr 5:66,456,046...66,776,127
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G |
Apex1 |
apurinic/apyrimidinic endonuclease 1 |
increases expression |
ISO |
Vitamin E results in increased expression of APEX1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
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G |
Aplp2 |
amyloid beta (A4) precursor-like protein 2 |
increases expression |
ISO |
Vitamin E results in increased expression of APLP2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 9:31,060,853...31,123,144
Ensembl chr 9:31,060,853...31,123,111
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G |
Apoa1 |
apolipoprotein A-I |
increases expression |
ISO |
Vitamin E results in increased expression of APOA1 protein |
CTD |
PMID:18458655 |
|
NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
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G |
Apob |
apolipoprotein B |
multiple interactions |
ISO |
[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Oleic Acid co-treated with Folic Acid co-treated with Vitamin B 6 co-treated with Vitamin E] results in decreased expression of APOB protein; Vitamin E promotes the reaction [Flavonoids inhibits the reaction [Copper results in increased oxidation of APOB protein]]; Vitamin E promotes the reaction [Quercetin inhibits the reaction [Copper results in increased oxidation of APOB protein]] |
CTD |
PMID:17237316 PMID:17475462 |
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NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
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G |
Apoe |
apolipoprotein E |
multiple interactions |
EXP |
Vitamin E inhibits the reaction [APOE mutant form results in increased abundance of 8,12-iso-isoprostane F2alpha-VI] |
CTD |
PMID:16303615 |
|
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
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G |
Apol7b |
apolipoprotein L 7b |
increases expression |
ISO |
Vitamin E results in increased expression of APOL3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:77,306,409...77,331,660
Ensembl chr15:77,306,409...77,331,692
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G |
Apom |
apolipoprotein M |
increases expression |
ISO |
Vitamin E results in increased expression of APOM mRNA |
CTD |
PMID:19244175 |
|
NCBI chr17:35,347,973...35,350,777
Ensembl chr17:35,347,973...35,351,026
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G |
App |
amyloid beta (A4) precursor protein |
decreases expression multiple interactions |
ISO EXP |
Vitamin E results in decreased expression of APP mRNA Vitamin E inhibits the reaction [APP protein modified form promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]]; Vitamin E inhibits the reaction [APP protein results in increased activity of CASP3] Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein] |
CTD |
PMID:12039845 PMID:12117551 PMID:15223066 PMID:19244175 |
|
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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|
G |
Appbp2 |
amyloid beta precursor protein (cytoplasmic tail) binding protein 2 |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of APPBP2 mRNA Vitamin E results in increased expression of APPBP2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr11:85,082,134...85,125,946
Ensembl chr11:85,078,088...85,125,956
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G |
Aqp1 |
aquaporin 1 |
increases expression |
ISO |
Vitamin E results in increased expression of AQP1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540
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G |
Aqp3 |
aquaporin 3 |
increases expression multiple interactions |
ISO |
Vitamin E results in increased expression of AQP3 mRNA [Selenium co-treated with Vitamin E] results in decreased expression of AQP3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
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G |
Aqp4 |
aquaporin 4 |
multiple interactions |
ISO EXP |
Vitamin E inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein] Vitamin E inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein] |
CTD |
PMID:20648640 PMID:30914277 |
|
NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
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|
G |
Araf |
Araf proto-oncogene, serine/threonine kinase |
multiple interactions |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of ARAF mRNA |
CTD |
PMID:19244175 |
|
NCBI chr X:20,663,946...20,726,760
Ensembl chr X:20,664,053...20,726,758
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G |
Arf3 |
ADP-ribosylation factor 3 |
increases expression |
ISO |
Vitamin E results in increased expression of ARF3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
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G |
Arf5 |
ADP-ribosylation factor 5 |
increases expression |
ISO |
Vitamin E results in increased expression of ARF5 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 6:28,423,603...28,426,601
Ensembl chr 6:28,423,559...28,426,601
|
|
G |
Arhgap10 |
Rho GTPase activating protein 10 |
increases expression |
ISO |
Vitamin E results in increased expression of ARHGAP10 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 8:77,976,995...78,244,628
Ensembl chr 8:77,976,995...78,244,582
|
|
G |
Arhgap8 |
Rho GTPase activating protein 8 |
increases expression |
ISO |
Vitamin E results in increased expression of ARHGAP8 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:84,604,214...84,657,058
Ensembl chr15:84,604,253...84,656,408
|
|
G |
Arhgdia |
Rho GDP dissociation inhibitor (GDI) alpha |
increases expression |
ISO |
Vitamin E results in increased expression of ARHGDIA mRNA |
CTD |
PMID:19244175 |
|
NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450
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|
G |
Arih1 |
ariadne RBR E3 ubiquitin protein ligase 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ARIH1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 9:59,295,837...59,395,469
Ensembl chr 9:59,295,541...59,393,901
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G |
Arl4d |
ADP-ribosylation factor-like 4D |
increases expression |
ISO |
Vitamin E results in increased expression of ARL4D mRNA |
CTD |
PMID:19244175 |
|
NCBI chr11:101,556,367...101,558,658
Ensembl chr11:101,556,367...101,558,658
|
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G |
Arl6ip4 |
ADP-ribosylation factor-like 6 interacting protein 4 |
increases expression |
ISO |
Vitamin E results in increased expression of ARL6IP4 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:124,254,171...124,256,258
Ensembl chr 5:124,254,152...124,256,259
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|
G |
Arpc1a |
actin related protein 2/3 complex, subunit 1A |
increases expression |
ISO |
Vitamin E results in increased expression of ARPC1A mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:145,020,679...145,045,566
Ensembl chr 5:145,020,640...145,045,571
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G |
Arpc4 |
actin related protein 2/3 complex, subunit 4 |
increases expression |
ISO |
Vitamin E results in increased expression of ARPC4 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 6:113,355,074...113,367,408
Ensembl chr 6:113,355,076...113,367,409
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|
G |
Asap3 |
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 |
increases expression |
ISO |
Vitamin E results in increased expression of ASAP3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 4:135,933,662...135,973,888
Ensembl chr 4:135,933,676...135,972,527
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G |
Asb1 |
ankyrin repeat and SOCS box-containing 1 |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of ASB1 mRNA Vitamin E results in increased expression of ASB1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 1:91,467,725...91,487,312
Ensembl chr 1:91,468,266...91,487,311
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|
G |
Asxl1 |
ASXL transcriptional regulator 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ASXL1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927
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G |
Atf2 |
activating transcription factor 2 |
increases phosphorylation |
ISO |
Vitamin E results in increased phosphorylation of ATF2 protein |
CTD |
PMID:11522656 |
|
NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
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G |
Atf3 |
activating transcription factor 3 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATF3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
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G |
Atf5 |
activating transcription factor 5 |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of ATF5 mRNA Vitamin E results in increased expression of ATF5 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082
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G |
Atg12 |
autophagy related 12 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATG12 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647
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G |
Atmin |
ATM interactor |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of ATMIN mRNA Vitamin E results in decreased expression of ATMIN mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 8:117,670,132...117,687,184
Ensembl chr 8:117,670,132...117,687,184
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G |
Atox1 |
antioxidant 1 copper chaperone |
increases expression |
ISO |
Vitamin E results in increased expression of ATOX1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr11:55,337,463...55,352,034
Ensembl chr11:55,337,467...55,352,065
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G |
Atp5b |
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit |
increases expression |
ISO |
Vitamin E results in increased expression of ATP5F1B mRNA |
CTD |
PMID:19244175 |
|
NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
|
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G |
Atp5c1 |
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATP5F1C mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321
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G |
Atp5k |
ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATP5ME mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:108,581,112...108,582,265
Ensembl chr 5:108,581,110...108,582,314
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|
G |
Atp6ap2 |
ATPase, H+ transporting, lysosomal accessory protein 2 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATP6AP2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr X:12,453,998...12,483,290
Ensembl chr X:12,454,040...12,483,288
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|
G |
Atp6v0d1 |
ATPase, H+ transporting, lysosomal V0 subunit D1 |
increases expression |
ISO |
Vitamin E results in increased expression of ATP6V0D1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 8:106,251,093...106,292,696
Ensembl chr 8:106,251,097...106,292,679
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|
G |
Atp6v1c1 |
ATPase, H+ transporting, lysosomal V1 subunit C1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATP6V1C1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr15:38,662,096...38,692,688
Ensembl chr15:38,662,177...38,692,690
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|
G |
Atp8b1 |
ATPase, class I, type 8B, member 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATP8B1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338
|
|
G |
Atrx |
ATRX, chromatin remodeler |
decreases expression multiple interactions |
ISO |
Vitamin E results in decreased expression of ATRX mRNA [Selenium co-treated with Vitamin E] results in decreased expression of ATRX mRNA |
CTD |
PMID:19244175 |
|
NCBI chr X:104,841,221...104,972,978
Ensembl chr X:104,841,221...104,973,009
|
|
G |
Atxn3 |
ataxin 3 |
decreases expression |
ISO |
Vitamin E results in decreased expression of ATXN3 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505
|
|
G |
Atxn7 |
ataxin 7 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of ATXN7 mRNA Vitamin E results in decreased expression of ATXN7 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr14:8,358,367...8,508,324
Ensembl chr14:8,362,461...8,508,323
|
|
G |
AU022252 |
expressed sequence AU022252 |
decreases expression multiple interactions |
ISO |
Vitamin E results in decreased expression of C1ORF50 mRNA [Selenium co-treated with Vitamin E] results in decreased expression of C1ORF50 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 4:119,078,576...119,089,985
Ensembl chr 4:119,060,767...119,089,909
|
|
G |
Auts2 |
autism susceptibility candidate 2 |
decreases expression |
ISO |
Vitamin E results in decreased expression of AUTS2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:131,466,171...132,572,059
Ensembl chr 5:131,466,171...132,572,183
|
|
G |
Axl |
AXL receptor tyrosine kinase |
decreases expression |
ISO |
Vitamin E results in decreased expression of AXL mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130
|
|
G |
Baat |
bile acid-Coenzyme A: amino acid N-acyltransferase |
increases expression |
ISO |
Vitamin E results in increased expression of BAAT mRNA |
CTD |
PMID:28923436 |
|
NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557
|
|
G |
Babam1 |
BRISC and BRCA1 A complex member 1 |
increases expression |
ISO |
Vitamin E results in increased expression of BABAM1 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 8:71,848,809...71,857,416
Ensembl chr 8:71,849,505...71,857,263
|
|
G |
Babam2 |
BRISC and BRCA1 A complex member 2 |
increases expression |
ISO |
Vitamin E results in increased expression of BABAM2 mRNA |
CTD |
PMID:19244175 |
|
NCBI chr 5:31,855,394...32,242,083
Ensembl chr 5:31,855,028...32,242,306
|
|
G |
Bag5 |
BCL2-associated athanogene 5 |
decreases expression |
ISO |
Vitamin E results in decreased expression of BAG5 mRNA |
CTD |
PMID:19244175 |
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NCBI chr12:111,675,922...111,679,690
Ensembl chr12:111,675,922...111,679,691
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Bag6 |
BCL2-associated athanogene 6 |
increases expression |
ISO |
Vitamin E results in increased expression of BAG6 mRNA |
CTD |
PMID:19244175 |
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NCBI chr17:35,354,132...35,366,297
Ensembl chr17:35,354,154...35,366,298
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Banf1 |
BAF nuclear assembly factor 1 |
increases expression |
ISO |
Vitamin E results in increased expression of BANF1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr19:5,414,661...5,416,904
Ensembl chr19:5,414,666...5,417,196
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Bap1 |
Brca1 associated protein 1 |
increases expression |
ISO |
Vitamin E results in increased expression of BAP1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr14:30,973,358...30,981,887
Ensembl chr14:30,973,407...30,981,901
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Bard1 |
BRCA1 associated RING domain 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of BARD1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 1:71,066,690...71,142,300
Ensembl chr 1:71,066,657...71,142,305
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Batf |
basic leucine zipper transcription factor, ATF-like |
increases expression |
ISO |
Vitamin E results in increased expression of BATF mRNA |
CTD |
PMID:19244175 |
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NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861
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Bax |
BCL2-associated X protein |
multiple interactions affects expression increases expression |
ISO |
Vitamin E inhibits the reaction [cinnamaldehyde results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]; Vitamin E inhibits the reaction [phenethyl isothiocyanate results in increased expression of BAX protein] [Vitamin E co-treated with Folic Acid] affects the expression of BAX protein; Vitamin E inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; Vitamin E inhibits the reaction [Diazinon results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Nanotubes, Carbon results in increased expression of BAX protein] Vitamin E affects the expression of BAX protein Vitamin E results in increased expression of BAX protein |
CTD |
PMID:11166918 PMID:15566391 PMID:16054126 PMID:16933212 PMID:22020378 PMID:23523949 PMID:27353299 PMID:30935902 More...
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NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
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Baz1a |
bromodomain adjacent to zinc finger domain 1A |
decreases expression |
ISO |
Vitamin E results in decreased expression of BAZ1A mRNA |
CTD |
PMID:19244175 |
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NCBI chr12:54,939,774...55,061,155
Ensembl chr12:54,939,774...55,061,133
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Baz1b |
bromodomain adjacent to zinc finger domain, 1B |
increases expression |
ISO |
Vitamin E results in increased expression of BAZ1B mRNA |
CTD |
PMID:19244175 |
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NCBI chr 5:135,214,094...135,274,985
Ensembl chr 5:135,216,118...135,274,983
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G |
Bbx |
bobby sox HMG box containing |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA Vitamin E results in decreased expression of BBX mRNA |
CTD |
PMID:19244175 |
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NCBI chr16:50,012,207...50,252,829
Ensembl chr16:50,012,207...50,252,753
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G |
Bcap31 |
B cell receptor associated protein 31 |
increases expression |
ISO |
Vitamin E results in increased expression of BCAP31 mRNA |
CTD |
PMID:19244175 |
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NCBI chr X:72,729,784...72,761,421
Ensembl chr X:72,729,784...72,759,781
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G |
Bche |
butyrylcholinesterase |
multiple interactions |
EXP |
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein] |
CTD |
PMID:20663516 |
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NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
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G |
Bcl11a |
B cell CLL/lymphoma 11A (zinc finger protein) |
decreases expression |
ISO |
Vitamin E results in decreased expression of BCL11A mRNA |
CTD |
PMID:19244175 |
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NCBI chr11:24,026,498...24,123,558
Ensembl chr11:24,028,056...24,124,123
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions increases expression |
ISO |
[Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BCL2 protein] Vitamin E results in increased expression of BCL2 mRNA [Vitamin E co-treated with Folic Acid] affects the expression of BCL2 protein; Vitamin E inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Vitamin E inhibits the reaction [Nanotubes, Carbon results in decreased expression of BCL2 protein] |
CTD |
PMID:15566391 PMID:16933212 PMID:22020378 PMID:27353299 PMID:30935902 PMID:32810592 More...
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Bcl2l1 |
BCL2-like 1 |
multiple interactions increases expression |
ISO |
[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of BCL2L1 mRNA Vitamin E results in increased expression of BCL2L1 mRNA |
CTD |
PMID:11444866 PMID:19244175 |
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NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
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G |
Bcl6 |
B cell leukemia/lymphoma 6 |
decreases expression |
ISO |
Vitamin E results in decreased expression of BCL6 mRNA |
CTD |
PMID:19244175 |
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NCBI chr16:23,783,800...23,807,623
Ensembl chr16:23,783,802...23,807,602
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G |
Bclaf1 |
BCL2-associated transcription factor 1 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of BCLAF1 mRNA Vitamin E results in decreased expression of BCLAF1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr10:20,187,897...20,218,390
Ensembl chr10:20,188,215...20,220,359
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G |
Bco1 |
beta-carotene oxygenase 1 |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]] |
CTD |
PMID:9526112 |
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NCBI chr 8:117,822,590...117,860,459
Ensembl chr 8:117,822,593...117,860,459
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G |
Becn1 |
beclin 1, autophagy related |
multiple interactions decreases expression |
ISO |
Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]; Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein] Vitamin E results in decreased expression of BECN1 protein |
CTD |
PMID:19138675 |
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NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
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G |
Bglap |
bone gamma carboxyglutamate protein |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [Doxorubicin results in increased expression of BGLAP protein] |
CTD |
PMID:32810592 |
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NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
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G |
Bicd1 |
BICD cargo adaptor 1 |
decreases expression multiple interactions |
ISO |
Vitamin E results in decreased expression of BICD1 mRNA [Selenium co-treated with Vitamin E] results in decreased expression of BICD1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:149,310,322...149,464,827
Ensembl chr 6:149,310,384...149,464,827
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G |
Bicd2 |
BICD cargo adaptor 2 |
decreases expression |
ISO |
Vitamin E results in decreased expression of BICD2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr13:49,495,025...49,540,502
Ensembl chr13:49,495,061...49,540,502
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G |
Bin1 |
bridging integrator 1 |
increases expression |
ISO |
Vitamin E results in increased expression of BIN1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr18:32,509,671...32,568,793
Ensembl chr18:32,510,283...32,568,790
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of BIRC2 mRNA Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BIRC2 protein] |
CTD |
PMID:11444866 PMID:15566391 |
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NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BIRC3 protein] |
CTD |
PMID:15566391 |
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NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein] |
CTD |
PMID:24664296 |
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NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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Blvra |
biliverdin reductase A |
increases expression |
ISO |
Vitamin E results in increased expression of BLVRA mRNA |
CTD |
PMID:19244175 |
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NCBI chr 2:126,912,549...126,939,004
Ensembl chr 2:126,912,585...126,939,004
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G |
Bmp2k |
BMP2 inducible kinase |
decreases expression |
ISO |
Vitamin E results in decreased expression of BMP2K mRNA |
CTD |
PMID:19244175 |
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NCBI chr 5:97,143,588...97,239,784
Ensembl chr 5:97,145,548...97,239,726
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G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression |
ISO |
Vitamin E results in increased expression of BMP4 mRNA |
CTD |
PMID:19244175 |
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NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126
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G |
Bptf |
bromodomain PHD finger transcription factor |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of BPTF mRNA Vitamin E results in decreased expression of BPTF mRNA |
CTD |
PMID:19244175 |
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NCBI chr11:106,923,907...107,022,982
Ensembl chr11:106,923,907...107,022,953
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G |
Brd2 |
bromodomain containing 2 |
multiple interactions increases expression decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of BRD2 mRNA Vitamin E results in increased expression of BRD2 mRNA Vitamin E results in decreased expression of BRD2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608
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G |
Brf2 |
BRF2, RNA polymerase III transcription initiation factor 50kDa subunit |
increases expression |
ISO |
Vitamin E results in increased expression of BRF2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 8:27,613,367...27,618,743
Ensembl chr 8:27,613,392...27,618,708
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G |
Brms1 |
breast cancer metastasis-suppressor 1 |
increases expression |
ISO |
Vitamin E results in increased expression of BRMS1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr19:5,091,391...5,099,940
Ensembl chr19:5,091,382...5,099,945
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G |
Bscl2 |
Berardinelli-Seip congenital lipodystrophy 2 (seipin) |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of BSCL2 mRNA Vitamin E results in increased expression of BSCL2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr19:8,814,831...8,826,047
Ensembl chr19:8,814,831...8,826,047
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G |
Bst2 |
bone marrow stromal cell antigen 2 |
increases expression |
ISO |
Vitamin E results in increased expression of BST2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 8:71,986,899...71,990,116
Ensembl chr 8:71,986,899...71,990,100
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G |
C1s1 |
complement component 1, s subcomponent 1 |
increases expression |
ISO |
Vitamin E results in increased expression of C1S mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:124,507,303...124,519,340
Ensembl chr 6:124,507,304...124,519,318
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G |
C77080 |
expressed sequence C77080 |
decreases expression |
ISO |
Vitamin E results in decreased expression of KIAA1522 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 4:129,113,371...129,155,197
Ensembl chr 4:129,113,371...129,155,197
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G |
C87436 |
expressed sequence C87436 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of C2ORF42 mRNA Vitamin E results in decreased expression of C2ORF42 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:86,411,616...86,447,370
Ensembl chr 6:86,415,356...86,450,482
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G |
Caap1 |
caspase activity and apoptosis inhibitor 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CAAP1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 4:94,388,315...94,445,712
Ensembl chr 4:94,388,318...94,445,033
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G |
Cab39 |
calcium binding protein 39 |
increases expression |
ISO |
Vitamin E results in increased expression of MO25 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 1:85,721,148...85,779,298
Ensembl chr 1:85,721,162...85,779,297
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G |
Cald1 |
caldesmon 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CALD1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
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G |
Calm3 |
calmodulin 3 |
increases expression |
ISO |
Vitamin E results in increased expression of CALM3 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 7:16,649,304...16,657,957
Ensembl chr 7:16,649,304...16,658,039
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G |
Calr |
calreticulin |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of CALR mRNA Vitamin E results in decreased expression of CALR mRNA |
CTD |
PMID:19244175 |
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NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
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G |
Calu |
calumenin |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of CALU mRNA Vitamin E results in increased expression of CALU mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II, beta |
increases expression |
ISO |
Vitamin E results in increased expression of CAMK2B mRNA |
CTD |
PMID:19244175 |
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NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
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G |
Camk2g |
calcium/calmodulin-dependent protein kinase II gamma |
decreases expression |
ISO |
Vitamin E results in decreased expression of CAMK2G mRNA |
CTD |
PMID:19244175 |
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NCBI chr14:20,784,941...20,844,225
Ensembl chr14:20,784,943...20,844,156
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G |
Cap1 |
CAP, adenylate cyclase-associated protein 1 (yeast) |
increases expression |
ISO |
Vitamin E results in increased expression of CAP1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 4:122,752,841...122,779,869
Ensembl chr 4:122,752,840...122,779,849
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G |
Capg |
capping protein (actin filament), gelsolin-like |
increases expression |
ISO |
Vitamin E results in increased expression of CAPG mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:72,515,265...72,539,966
Ensembl chr 6:72,521,374...72,539,966
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G |
Capn7 |
calpain 7 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CAPN7 mRNA |
CTD |
PMID:19244175 |
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NCBI chr14:31,058,582...31,093,944
Ensembl chr14:31,058,595...31,093,943
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G |
Capns1 |
calpain, small subunit 1 |
increases expression |
ISO |
Vitamin E results in increased expression of CAPNS1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 7:29,886,359...29,898,308
Ensembl chr 7:29,886,361...29,898,236
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G |
Caprin2 |
caprin family member 2 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CAPRIN2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:148,743,990...148,797,756
Ensembl chr 6:148,743,990...148,797,735
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G |
Capzb |
capping protein (actin filament) muscle Z-line, beta |
increases expression |
ISO |
Vitamin E results in increased expression of CAPZB mRNA |
CTD |
PMID:19244175 |
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NCBI chr 4:138,920,210...139,019,131
Ensembl chr 4:138,920,210...139,019,129
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G |
Car3 |
carbonic anhydrase 3 |
multiple interactions |
ISO |
[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNA |
CTD |
PMID:11444866 |
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NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583
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G |
Casc3 |
cancer susceptibility candidate 3 |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of MLN51 mRNA Vitamin E results in increased expression of MLN51 mRNA |
CTD |
PMID:19244175 |
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NCBI chr11:98,700,634...98,724,633
Ensembl chr11:98,695,731...98,724,640
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
ISO EXP |
Vitamin E inhibits the reaction [cinnamaldehyde results in increased activity of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form]; Vitamin E inhibits the reaction [phenethyl isothiocyanate results in increased activity of CASP3 protein] Vitamin E results in increased expression of CASP3 mRNA Vitamin E inhibits the reaction [titanium dioxide results in increased activity of CASP3 protein] [Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [APP protein results in increased activity of CASP3]; Vitamin E inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; Vitamin E inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; Vitamin E inhibits the reaction [Doxorubicin results in decreased expression of CASP3 mRNA]; Vitamin E inhibits the reaction [Nanotubes, Carbon results in increased activity of CASP3 protein] |
CTD |
PMID:12117551 PMID:15566391 PMID:16054126 PMID:16973328 PMID:21628957 PMID:21873648 PMID:22020378 PMID:23523949 PMID:27353299 PMID:28237877 PMID:30626778 PMID:30935902 PMID:32810592 More...
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Casp9 |
caspase 9 |
increases expression multiple interactions |
ISO |
Vitamin E results in increased expression of CASP9 mRNA [Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP9 protein]; [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; Vitamin E inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein] |
CTD |
PMID:16973328 PMID:19244175 PMID:21628957 PMID:27353299 |
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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G |
Cat |
catalase |
multiple interactions increases expression decreases activity affects expression |
ISO EXP |
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Air Pollutants, Occupational affects the expression of CAT protein]; [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; [Ascorbic Acid co-treated with Vitamin E] results in increased expression of CAT mRNA; Vitamin E inhibits the reaction [Aluminum results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Dimethoate results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Oleic Acid results in decreased activity of CAT protein] Vitamin E results in increased expression of CAT protein [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; [Vitamin E co-treated with Quercetin] inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; [Vitamin E co-treated with Sodium Selenite] inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; [Vitamin E inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein]] which affects the abundance of Reactive Oxygen Species; [Zinc co-treated with Vitamin E co-treated with Ascorbic Acid co-treated with sodium arsenite] results in increased activity of CAT protein; Ginkgo biloba extract promotes the reaction [Vitamin E inhibits the reaction [endotoxin, Escherichia coli results in decreased activity of CAT protein]]; Vitamin E inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Cadmium results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Carbofuran results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [chromium hexavalent ion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Cyclosporine results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Dimethoate results in increased activity of CAT protein]; Vitamin E inhibits the reaction [endotoxin, Escherichia coli results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Food Additives affects the activity of CAT protein]; Vitamin E inhibits the reaction [Formaldehyde results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Methoxychlor results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Petroleum results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Tetrachlorodibenzodioxin results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of CAT protein]; Vitamin E promotes the reaction [Ginkgo biloba extract inhibits the reaction [endotoxin, Escherichia coli results in decreased activity of CAT protein]] Vitamin E results in decreased activity of CAT protein [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [fipronil results in decreased activity of CAT protein] Vitamin E affects the expression of CAT protein |
CTD |
PMID:11597945 PMID:11834209 PMID:11955947 PMID:12355564 PMID:14535831 PMID:15669049 PMID:15820619 PMID:16144695 PMID:16298753 PMID:16758767 PMID:16937016 PMID:17262218 PMID:17383094 PMID:17709913 PMID:17927767 PMID:18655177 PMID:19914224 PMID:19958828 PMID:20077558 PMID:20079796 PMID:20535553 PMID:21086752 PMID:21628957 PMID:21736874 PMID:21787585 PMID:22020378 PMID:22207723 PMID:23348005 PMID:23369933 PMID:23619517 PMID:24865641 PMID:25046308 PMID:25721553 PMID:29948670 More...
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Cav1 |
caveolin 1, caveolae protein |
multiple interactions |
EXP |
Vitamin E inhibits the reaction [Hydrogen Peroxide results in increased expression of CAV1 protein] |
CTD |
PMID:12134086 |
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NCBI chr 6:17,306,287...17,341,327
Ensembl chr 6:17,306,334...17,341,451
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Cavin1 |
caveolae associated 1 |
multiple interactions increases expression |
ISO |
Vitamin E inhibits the reaction [Hydrogen Peroxide results in increased expression of CAVIN1 protein] Vitamin E results in increased expression of CAVIN1 mRNA |
CTD |
PMID:19244175 PMID:21705337 |
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NCBI chr11:100,847,562...100,861,443
Ensembl chr11:100,847,559...100,861,713
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Cavin3 |
caveolae associated 3 |
increases expression |
ISO |
Vitamin E results in increased expression of CAVIN3 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 7:105,129,823...105,131,404
Ensembl chr 7:105,129,290...105,131,507
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Cblb |
Casitas B-lineage lymphoma b |
decreases expression |
ISO |
Vitamin E results in decreased expression of CBLB mRNA |
CTD |
PMID:19244175 |
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NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411
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Cbx5 |
chromobox 5 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of CBX5 mRNA Vitamin E results in decreased expression of CBX5 mRNA |
CTD |
PMID:19244175 |
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NCBI chr15:103,099,973...103,148,337
Ensembl chr15:103,099,971...103,148,243
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Cbx6 |
chromobox 6 |
increases expression |
ISO |
Vitamin E results in increased expression of CBX6 mRNA |
CTD |
PMID:19244175 |
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NCBI chr15:79,708,099...79,718,534
Ensembl chr15:79,708,097...79,718,889
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Cbx7 |
chromobox 7 |
increases expression |
ISO |
Vitamin E results in increased expression of CBX7 mRNA |
CTD |
PMID:19244175 |
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NCBI chr15:79,800,005...79,855,344
Ensembl chr15:79,800,008...79,855,320
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Cby1 |
chibby family member 1, beta catenin antagonist |
increases expression |
ISO |
Vitamin E results in increased expression of CBY1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr15:79,543,357...79,551,863
Ensembl chr15:79,543,400...79,551,861
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Ccdc85b |
coiled-coil domain containing 85B |
multiple interactions increases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of DIPA mRNA Vitamin E results in increased expression of DIPA mRNA |
CTD |
PMID:19244175 |
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NCBI chr19:5,503,191...5,507,591
Ensembl chr19:5,503,208...5,507,922
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Cchcr1 |
coiled-coil alpha-helical rod protein 1 |
increases expression |
ISO |
Vitamin E results in increased expression of CCHCR1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr17:35,827,914...35,841,912
Ensembl chr17:35,827,997...35,841,912
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Ccl2 |
chemokine (C-C motif) ligand 2 |
multiple interactions increases expression |
EXP |
alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein]; Quercetin inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein] |
CTD |
PMID:19735175 |
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NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Ccl5 |
chemokine (C-C motif) ligand 5 |
multiple interactions |
ISO |
[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNA |
CTD |
PMID:16797527 |
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NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
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Ccnd1 |
cyclin D1 |
increases expression multiple interactions affects expression |
ISO |
Vitamin E results in increased expression of CCND1 mRNA Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein] Vitamin E affects the expression of CCND1 mRNA; Vitamin E affects the expression of CCND1 protein [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CCND1 mRNA |
CTD |
PMID:11444866 PMID:16298738 PMID:19244175 PMID:30935902 |
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NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccnd2 |
cyclin D2 |
increases expression |
ISO |
Vitamin E results in increased expression of CCND2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
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Ccnd3 |
cyclin D3 |
affects expression |
ISO |
Vitamin E affects the expression of CCND3 mRNA |
CTD |
PMID:15370891 |
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NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
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Ccne1 |
cyclin E1 |
affects expression |
ISO |
Vitamin E affects the expression of CCNE1 mRNA |
CTD |
PMID:16298738 |
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NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
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Ccnl1 |
cyclin L1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CCNL1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 3:65,853,333...65,869,451
Ensembl chr 3:65,853,572...65,865,670
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Ccpg1 |
cell cycle progression 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CPR8 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 9:72,892,692...72,923,622
Ensembl chr 9:72,892,711...72,923,622
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Ccs |
copper chaperone for superoxide dismutase |
increases expression |
ISO |
Vitamin E results in increased expression of CCS mRNA |
CTD |
PMID:19244175 |
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NCBI chr19:4,875,394...4,889,384
Ensembl chr19:4,875,394...4,889,360
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Cd2bp2 |
CD2 cytoplasmic tail binding protein 2 |
increases expression |
ISO |
Vitamin E results in increased expression of CD2BP2 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 7:126,790,832...126,795,249
Ensembl chr 7:126,790,832...126,795,222
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Cd44 |
CD44 antigen |
decreases expression |
ISO |
Vitamin E results in decreased expression of CD44 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
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Cd63 |
CD63 antigen |
increases expression |
ISO |
Vitamin E results in increased expression of CD63 mRNA |
CTD |
PMID:19244175 |
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NCBI chr10:128,731,577...128,748,691
Ensembl chr10:128,736,858...128,748,691
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Cd86 |
CD86 antigen |
multiple interactions |
ISO |
Vitamin E inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Vitamin E inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Vitamin E inhibits the reaction [Thimerosal results in increased expression of CD86 protein] |
CTD |
PMID:20457211 |
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NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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Cd99 |
CD99 antigen |
increases expression |
ISO |
Vitamin E results in increased expression of CD99 mRNA |
CTD |
PMID:19244175 |
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Cdc14b |
CDC14 cell division cycle 14B |
decreases expression |
ISO |
Vitamin E results in decreased expression of CDC14B mRNA |
CTD |
PMID:19244175 |
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NCBI chr13:64,337,085...64,423,670
Ensembl chr13:64,337,082...64,423,104
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Cdc16 |
CDC16 cell division cycle 16 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CDC16 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 8:13,807,650...13,831,951
Ensembl chr 8:13,807,676...13,831,938
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Cdc25b |
cell division cycle 25B |
increases expression |
ISO |
Vitamin E results in increased expression of CDC25B mRNA |
CTD |
PMID:19244175 |
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NCBI chr 2:131,028,356...131,040,431
Ensembl chr 2:131,028,869...131,040,417
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Cdc27 |
cell division cycle 27 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CDC27 mRNA |
CTD |
PMID:19244175 |
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NCBI chr11:104,393,350...104,441,446
Ensembl chr11:104,393,571...104,441,446
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Cdc42bpa |
CDC42 binding protein kinase alpha |
multiple interactions increases expression decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNA Vitamin E results in increased expression of CDC42BPA mRNA Vitamin E results in decreased expression of CDC42BPA mRNA |
CTD |
PMID:19244175 |
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NCBI chr 1:179,787,058...179,993,171
Ensembl chr 1:179,788,037...179,993,168
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Cdh2 |
cadherin 2 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CDH2 protein] |
CTD |
PMID:29940330 |
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NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
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Cdh3 |
cadherin 3 |
increases expression |
ISO |
Vitamin E results in increased expression of CDH3 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 8:107,237,484...107,283,543
Ensembl chr 8:107,237,523...107,283,929
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Cdk10 |
cyclin-dependent kinase 10 |
multiple interactions |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of CDK10 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 8:123,951,580...123,958,995
Ensembl chr 8:123,951,581...123,958,989
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Cdk13 |
cyclin-dependent kinase 13 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CDK13 mRNA |
CTD |
PMID:19244175 |
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NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682
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Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
ISO |
Vitamin E results in increased expression of CDK4 mRNA |
CTD |
PMID:19244175 |
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NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A (P21) |
affects expression multiple interactions |
ISO |
Vitamin E affects the expression of CDKN1A mRNA Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein] |
CTD |
PMID:16298738 PMID:30935902 |
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NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
Vitamin E results in increased expression of CDKN1B protein |
CTD |
PMID:12352461 |
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NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
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Cds1 |
CDP-diacylglycerol synthase 1 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CDS1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 5:101,912,996...101,971,724
Ensembl chr 5:101,912,996...101,971,724
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Cebpa |
CCAAT/enhancer binding protein (C/EBP), alpha |
multiple interactions |
EXP |
Vitamin E inhibits the reaction [Ethanol results in decreased activity of CEBPA protein]; Vitamin E inhibits the reaction [Ethanol results in decreased expression of CEBPA protein] |
CTD |
PMID:16737972 |
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NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
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G |
Cebpb |
CCAAT/enhancer binding protein (C/EBP), beta |
increases response to substance |
ISO |
CEBPB results in increased susceptibility to Vitamin E |
CTD |
PMID:9359698 |
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NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
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Cep164 |
centrosomal protein 164 |
increases expression |
ISO |
Vitamin E results in increased expression of CEP164 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 9:45,678,244...45,739,984
Ensembl chr 9:45,678,244...45,739,989
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Cep170 |
centrosomal protein 170 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CEP170 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 1:176,556,638...176,641,545
Ensembl chr 1:176,561,219...176,641,633
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Cep290 |
centrosomal protein 290 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CEP290 mRNA |
CTD |
PMID:19244175 |
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NCBI chr10:100,323,410...100,411,533
Ensembl chr10:100,323,420...100,410,702
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Cep350 |
centrosomal protein 350 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of CEP350 mRNA Vitamin E results in decreased expression of CEP350 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 1:155,720,710...155,849,001
Ensembl chr 1:155,720,710...155,849,001
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Cep57 |
centrosomal protein 57 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in decreased expression of CEP57 mRNA Vitamin E results in decreased expression of CEP57 mRNA |
CTD |
PMID:19244175 |
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NCBI chr 9:13,717,979...13,738,698
Ensembl chr 9:13,719,088...13,738,403
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Cep97 |
centrosomal protein 97 |
decreases expression |
ISO |
Vitamin E results in decreased expression of CEP97 mRNA |
CTD |
PMID:19244175 |
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NCBI chr16:55,720,250...55,755,237
Ensembl chr16:55,720,251...55,755,218
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Cerk |
ceramide kinase |
increases expression |
ISO |
Vitamin E results in increased expression of CERK mRNA |
CTD |
PMID:19244175 |
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NCBI chr15:86,023,302...86,070,537
Ensembl chr15:86,023,329...86,070,342
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Cert1 |
ceramide transporter 1 |
multiple interactions decreases expression |
ISO |
[Selenium co-treated with Vitamin E] results in increased expression of CERT1 mRNA Vitamin E results in decreased expression of CERT1 mRNA |
CTD |
PMID:19244175 |
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NCBI chr13:96,679,243...96,782,362
Ensembl chr13:96,679,126...96,776,675
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