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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SNX-2112
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Accession:CHEBI:231695 term browser browse the term
Definition:SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor.
Synonyms:related_synonym: 4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide;   Formula=C23H27F3N4O3;   InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33);   InChIKey=ZFVRYNYOPQZKDG-UHFFFAOYSA-N;   PF-04928473;   SMILES=CC1(C)CC2=C(C(C1)=O)C(C(F)(F)F)=NN2C=3C=CC(=C(C3)NC4CCC(CC4)O)C(=N)O;   SNX2112
 xref: CAS:908112-43-6
 xref_mesh: MESH:C534922


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SNX-2112 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO SNX 2112 results in decreased expression of and results in decreased activity of ABCB1 protein CTD PMID:23777986 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO SNX 2112 results in decreased expression of AKT1 protein; SNX 2112 results in decreased expression of AKT1 protein modified form CTD PMID:23777986 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO SNX 2112 results in increased expression of BAX protein CTD PMID:23777986 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO SNX 2112 results in decreased expression of BCL2 protein CTD PMID:23777986 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO SNX 2112 results in decreased expression of BCL2L1 protein CTD PMID:23777986 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases expression ISO SNX 2112 results in increased expression of CASP3 protein modified form CTD PMID:23777986 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO SNX 2112 results in increased activity of CASP8 protein CTD PMID:23777986 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression ISO SNX 2112 results in increased expression of CASP9 protein modified form CTD PMID:23777986 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO SNX 2112 results in decreased expression of CHUK protein CTD PMID:23777986 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO SNX 2112 affects the localization of CYCS protein CTD PMID:23777986 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression ISO SNX 2112 results in decreased expression of HSP90B1 protein CTD PMID:23777986 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO SNX 2112 results in decreased expression of HSPA5 protein CTD PMID:23777986 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO SNX 2112 results in increased cleavage of PARP1 protein CTD PMID:23777986 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO SNX 2112 results in decreased expression of RELA protein alternative form CTD PMID:23777986 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Trap1 TNF receptor-associated protein 1 decreases expression ISO SNX 2112 results in decreased expression of TRAP1 protein CTD PMID:23777986 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      atom 19909
        nonmetal atom 19832
          carbon atom 19785
            organic molecular entity 19785
              SNX-2112 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            SNX-2112 15
paths to the root