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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ono-AE1-329
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Accession:CHEBI:231670 term browser browse the term
Definition:Ono-AE1-329 is a novel agonist of the prostaglandin PGE2 receptor EP4.
Synonyms:related_synonym: 2-[3-[(1R,2S,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-[2-(methoxymethyl)phenyl]pent-1-enyl]-5-oxocyclopentyl]sulfanylpropylsulfanyl]acetic acid;   AE 1-329;   Formula=C23H32O6S2;   InChI=1S/C23H32O6S2/c1-29-14-17-6-3-2-5-16(17)7-8-18(24)9-10-19-20(25)13-21(26)23(19)31-12-4-11-30-15-22(27)28/h2-3,5-6,9-10,18-20,23-25H,4,7-8,11-15H2,1H3,(H,27,28)/b10-9+;   InChIKey=BVGVPUMSPSNRRQ-MDZDMXLPSA-N;   SMILES=COCC1=CC=CC=C1CCC(/C=C/C2C(CC(=O)C2SCCCSCC(=O)O)O)O
 xref_mesh: MESH:C461399


show annotations for term's descendants           Sort by:
Ono-AE1-329 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 multiple interactions ISO ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 mRNA]; ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 protein]; PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 mRNA]]; PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 protein]] CTD PMID:11301049 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP ONO-AE1-329 inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11991626 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP ONO-AE1-329 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11991626 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression
multiple interactions		 EXP ONO-AE1-329 results in increased expression of PPP1R9B protein
[ONO-AE1-329 co-treated with ONO AE 248] results in increased expression of PPP1R9B protein		 CTD PMID:18726914 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF mRNA]]; PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF protein]]; PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 mRNA]]; PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 protein]] CTD PMID:11301049 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF protein]; PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF mRNA]]; PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF protein]] CTD PMID:11301049 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    chemical entity 19915
      atom 19915
        nonmetal atom 19838
          carbon atom 19790
            organic molecular entity 19790
              Ono-AE1-329 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            Ono-AE1-329 6
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