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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:XMU-MP-1
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Accession:CHEBI:231615 term browser browse the term
Definition:An organic heterotricyclic compound that is 5,10-dihydro-6H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-6-one substituted by (4-sulfamoylphenyl)amino, methyl and methyl groups at positions 2, 5 and 10, respectively. It is an inhibitor of the Hippo pathway kinases MST1 and MST2 (IC50 = 71.1 and 38.1 nM, respectively).
Synonyms:related_synonym: 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide;   Formula=C17H16N6O3S2;   InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21);   InChIKey=YRDHKIFCGOZTGD-UHFFFAOYSA-N;   SMILES=CN1C2=C(SC=C2)C(=O)N(C)C2=CN=C(NC3=CC=C(C=C3)S(N)(=O)=O)N=C12;   XMU-MP1
 xref: CAS:2061980-01-4
 xref_mesh: MESH:C000625617
 xref: PMID:27535619;   PMID:30806090;   PMID:31328787;   PMID:32973917;   PMID:32987643;   PMID:33887258;   PMID:34007939;   PMID:35088536;   PMID:35123978;   PMID:35731253;   PMID:36199358;   PMID:36495715;   PMID:37251938;   PMID:37277791;   PMID:37551490;   PMID:37661231;   PMID:37882715;   PMID:38043154;   PMID:38760516;   PMID:38965852


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XMU-MP-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression 		ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA]
XMU-MP-1 results in increased expression of ABCG2 mRNA 		CTD PMID:31916386 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases activity ISO XMU-MP-1 results in increased activity of ALDH1 protein CTD PMID:31916386 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased expression of BAX protein] CTD PMID:31044527 PMID:32057900 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of BCL2 protein] CTD PMID:32057900 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein] CTD PMID:31044527 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of BIRC5 protein] CTD PMID:32057900 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased cleavage of CASP3 protein] CTD PMID:31044527 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of CCN2 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]
[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA; Verteporfin inhibits the reaction [[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA] 		CTD PMID:31044527 PMID:32057900 PMID:35027733 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of EPCAM mRNA]; XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of EPCAM protein] CTD PMID:33405312 NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of JUN protein] CTD PMID:31044527 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions ISO XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of KLF4 mRNA]; XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of KLF4 protein] CTD PMID:33405312 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592 		JBrowse link
G Lats1 large tumor suppressor kinase 1 decreases phosphorylation
multiple interactions 		ISO XMU-MP-1 results in decreased phosphorylation of LATS1 protein
XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of and results in increased phosphorylation of LATS1 protein]; XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of LATS1 mRNA] 		CTD PMID:32057900 PMID:35027733 NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of JUN protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK1 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK3 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of YAP1 protein] CTD PMID:31044527 NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:77,537,956...77,697,538 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:31044527 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:31044527 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mst1 macrophage stimulating 1 decreases expression
multiple interactions 		ISO XMU-MP-1 results in decreased expression of MST1 mRNA; XMU-MP-1 results in decreased expression of MST1 protein
XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of MST1 mRNA]; XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of MST1 protein] 		CTD PMID:32057900 NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015 		JBrowse link
G Mt1a metallothionein 1A multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; XMU-MP-1 promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]
XMU-MP-1 promotes the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]; XMU-MP-1 promotes the reaction [zinc chloride results in increased expression of MT1A mRNA] 		CTD PMID:35027733 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]; XMU-MP-1 promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA] CTD PMID:35027733 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Prom1 prominin 1 multiple interactions
increases expression 		ISO XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of PROM1 mRNA]; XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of PROM1 protein]; XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]
XMU-MP-1 results in increased expression of PROM1 mRNA 		CTD PMID:31916386 PMID:33405312 NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002 		JBrowse link
G Stk3 serine/threonine kinase 3 multiple interactions
decreases expression 		ISO XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of STK3 mRNA]
XMU-MP-1 results in decreased expression of STK3 mRNA; XMU-MP-1 results in decreased expression of STK3 protein 		CTD PMID:32057900 NCBI chr 7:67,938,341...68,208,472
Ensembl chr 7:67,938,378...68,208,508 		JBrowse link
G Stk4 serine/threonine kinase 4 multiple interactions ISO XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of STK4 protein modified form] CTD PMID:34845814 NCBI chr 3:173,165,238...173,247,135
Ensembl chr 3:173,165,083...173,247,134 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of TP53 protein] CTD PMID:32057900 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases phosphorylation
multiple interactions 		ISO XMU-MP-1 results in decreased phosphorylation of YAP1 protein
XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of YAP1 mRNA]; XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of YAP1 protein]; XMU-MP-1 inhibits the reaction [evodiamine results in increased phosphorylation of YAP1 protein]; XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of YAP1 protein modified form]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of YAP1 protein] 		CTD PMID:31044527 PMID:32057900 PMID:34845814 PMID:35027733 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437 		JBrowse link
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  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            bone density conservation agent 6104
              XMU-MP-1 23
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  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      chalcogen 20491
                        oxygen atom 20457
                          oxygen molecular entity 20457
                            hydroxides 20230
                              oxoacid 19289
                                chalcogen oxoacid 13891
                                  sulfur oxoacid 13683
                                    sulfonic acid 11712
                                      sulfonic acid derivative 11712
                                        sulfonamide 5379
                                          XMU-MP-1 23
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