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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tasquinimod
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Accession:CHEBI:231355 term browser browse the term
Definition:Tasquinimod is a quinoline-3-carboxamide linomide analogue with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of action is not known. This agent has also been shown to augment the antineoplastic effects of docetaxel and androgen ablation in a murine model of prostate cancer involving human prostate cancer xenografts.
Synonyms:related_synonym: ABR-215050;   Formula=C20H17F3N2O4;   InChI=1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3;   InChIKey=ONDYALNGTUAJDX-UHFFFAOYSA-N;   SMILES=CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O
 xref: CAS:254964-60-8
 xref_mesh: MESH:C516109


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tasquinimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects binding
increases activity		 EXP tasquinimod analog binds to AHR protein
tasquinimod analog results in increased activity of AHR protein		 CTD PMID:28433708 PMID:29908305 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP tasquinimod analog results in increased expression of AHRR mRNA CTD PMID:28433708 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP tasquinimod analog results in increased expression of CYP1A1 mRNA; tasquinimod analog results in increased expression of CYP1A1 protein; tasquinimod metabolite results in increased expression of CYP1A1 protein CTD PMID:28433708 PMID:29908305 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP tasquinimod analog results in increased expression of CYP1A2 mRNA CTD PMID:28433708 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      atom 19909
        nonmetal atom 19832
          carbon atom 19785
            organic molecular entity 19785
              tasquinimod 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            tasquinimod 4
paths to the root