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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:talazoparib
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Accession:CHEBI:231344 term browser browse the term
Definition:Talazoparib is an orally available small molecule inhibitor of the DNA repair enzyme poly ADP-ribose polymerase (PARP) which is used as an antineoplastic agent in the treatment of selected cases of breast cancer. Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.
Synonyms:related_synonym: BMN-673;   BMN673;   Formula=C19H14F2N6O;   InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1;   InChIKey=HWGQMRYQVZSGDQ-HZPDHXFCSA-N;   SMILES=CN1C(=NC=N1)[C@@H]2[C@H](NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
 xref: CAS:1207456-01-6
 xref_mesh: MESH:C586365


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talazoparib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO talazoparib affects the expression of BAX mRNA CTD PMID:30672063 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO talazoparib affects the expression of BCL2 mRNA CTD PMID:30672063 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases response to substance ISO BRCA1 gene mutant form results in increased susceptibility to talazoparib CTD PMID:30672063 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Ccnd1 cyclin D1 affects expression ISO talazoparib affects the expression of CCND1 mRNA CTD PMID:30672063 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO talazoparib affects the expression of CDKN1A mRNA CTD PMID:30672063 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Fh fumarate hydratase increases response to substance ISO FH mutant form results in increased susceptibility to talazoparib CTD PMID:30013182 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO talazoparib binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases activity ISO talazoparib results in decreased activity of PARP2 protein CTD PMID:28001384 NCBI chr15:26,494,722...26,517,893
Ensembl chr15:26,494,731...26,517,891 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression ISO talazoparib affects the expression of RB1 mRNA CTD PMID:30672063 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B increases response to substance ISO SDHB mutant form results in increased susceptibility to talazoparib CTD PMID:30013182 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    chemical entity 20871
      atom 20871
        nonmetal atom 20779
          carbon atom 20722
            organic molecular entity 20722
              talazoparib 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      carbon group element atom 20727
                        carbon atom 20722
                          organic molecular entity 20722
                            talazoparib 10
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