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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cerebroside
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Accession:CHEBI:23079 term browser browse the term
Definition:Any member of a group of glycosphingolipids, also known as monoglycosylceramides, which are important components in animal muscle and nerve cell membranes.
Synonyms:related_synonym: cerebrosides;   monoglycosylceramide;   monoglycosylceramides


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1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO KRN 7000 results in increased expression of CXCL10 protein CTD PMID:15867097 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Il12b interleukin 12B increases expression ISO KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
alpha-galactosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of GATA3 mRNA CTD PMID:30803854 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein CTD PMID:30993380 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion		 ISO [Alcohols co-treated with alpha-galactosylceramide] results in increased expression of IFNG protein; [Ovalbumin co-treated with alpha-galactosylceramide] results in increased secretion of IFNG protein
alpha-galactosylceramide results in increased secretion of IFNG protein		 CTD PMID:12482940 PMID:25499027 PMID:30803854 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL10 protein CTD PMID:30803854 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL13 protein CTD PMID:30803854 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL17A protein CTD PMID:30803854 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il4 interleukin 4 increases secretion
multiple interactions		 ISO alpha-galactosylceramide results in increased secretion of IL4 protein
[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL4 protein		 CTD PMID:12482940 PMID:30803854 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL5 protein CTD PMID:30803854 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Klrb1b killer cell lectin like receptor B1B decreases expression ISO alpha-galactosylceramide results in decreased expression of KLRB1C protein CTD PMID:30993380 NCBI chr 4:161,948,259...161,961,537
Ensembl chr 4:161,890,577...161,961,675 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of RORC mRNA alternative form CTD PMID:30803854 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in increased expression of TBX21 mRNA CTD PMID:30803854 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
phytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions		 ISO phytosphingosine affects the localization of AIFM1 protein
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]		 CTD PMID:15486061 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]
phytosphingosine affects the localization of BAX protein
phytosphingosine results in increased expression of BAX protein		 CTD PMID:15486061 PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO phytosphingosine results in increased expression of BCL2 protein CTD PMID:36334778 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; phytosphingosine results in increased expression of and results in increased cleavage of CASP3 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]
phytosphingosine results in increased expression of CASP3 protein		 CTD PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]
phytosphingosine results in increased expression of CASP9 protein		 CTD PMID:17237268 PMID:37956922 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO phytosphingosine results in decreased expression of CCNB1 protein CTD PMID:37956922 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO phytosphingosine results in decreased expression of CDK1 protein CTD PMID:37956922 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO phytosphingosine results in increased expression of CYCS protein CTD PMID:36334778 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein CTD PMID:17237268 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein] CTD PMID:17237268 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein CTD PMID:17237268 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
increases cleavage		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]
phytosphingosine results in increased activity of PARP1 protein
phytosphingosine results in increased cleavage of PARP1 protein		 CTD PMID:15486061 PMID:17237268 PMID:37956922 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pink1 PTEN induced kinase 1 decreases expression ISO phytosphingosine results in decreased expression of PINK1 protein CTD PMID:36334778 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          carbon atom 19734
            organic molecular entity 19705
              lipid 17920
                sphingolipid 216
                  ceramide 127
                    cerebroside 25
                      HexCer(d32:1) 0
                      HexCer(d33:2) 0
                      HexCer(d34:1) + 0
                      HexCer(d37:2) 0
                      HexCer(d42:1) 0
                      HexCer(d42:2) + 0
                      N-(docosanoyl)-1-(2',3',4',6'-tetraacetylbeta-D-galactosyl)-3-acetylsphingosine 0
                      N-tetracosanoyl hexosylceramide 0
                      alpha-D-galactosyl-N-(hexacosanoyl)-11,12-methylene-C22-sphinganine 0
                      galactosylceramide + 25
                      glucosylceramide + 0
                      hexosyl-(1<->1')-N-acylsphinganine + 0
                      hexosyl-(1<->1')-N-acylsphingosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              ceramide 127
                                                cerebroside 25
                                                  HexCer(d32:1) 0
                                                  HexCer(d33:2) 0
                                                  HexCer(d34:1) + 0
                                                  HexCer(d37:2) 0
                                                  HexCer(d42:1) 0
                                                  HexCer(d42:2) + 0
                                                  N-(docosanoyl)-1-(2',3',4',6'-tetraacetylbeta-D-galactosyl)-3-acetylsphingosine 0
                                                  N-tetracosanoyl hexosylceramide 0
                                                  alpha-D-galactosyl-N-(hexacosanoyl)-11,12-methylene-C22-sphinganine 0
                                                  galactosylceramide + 25
                                                  glucosylceramide + 0
                                                  hexosyl-(1<->1')-N-acylsphinganine + 0
                                                  hexosyl-(1<->1')-N-acylsphingosine 0
paths to the root