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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:misonidazole
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Accession:CHEBI:230671 term browser browse the term
Synonyms:exact_synonym: 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
 related_synonym: Formula=C7H11N3O4;   InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3;   InChIKey=OBBCSXFCDPPXOL-UHFFFAOYSA-N;   SMILES=OC(CN1C(=NC=C1)[N+]([O-])=O)COC
 xref: Chemspider:24317;   DrugBank:DB11716;   HMDB:HMDB0254755;   KEGG:D05052
 xref_mesh: MESH:D008920


show annotations for term's descendants           Sort by:
misonidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Misonidazole CTD PMID:2943713 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Glb1 galactosidase, beta 1 increases activity EXP Misonidazole results in increased activity of GLB1 protein CTD PMID:7459223 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Gss glutathione synthetase increases response to substance ISO GSS gene mutant form results in increased susceptibility to Misonidazole CTD PMID:3874843 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gusb glucuronidase, beta increases activity
multiple interactions		 EXP
ISO		 Misonidazole results in increased activity of GUSB protein
Dexamethasone inhibits the reaction [Misonidazole results in increased activity of GUSB protein]; Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein]; Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]		 CTD PMID:6696821 PMID:7073948 PMID:7107415 PMID:7459223 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases metabolic processing		 EXP desmethylmisonidazole inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Flavins promotes the reaction [POR protein results in increased metabolism of Misonidazole]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Paraquat promotes the reaction [POR protein results in increased metabolism of Misonidazole] CTD PMID:6802140 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Th tyrosine hydroxylase increases expression
increases activity		 ISO Misonidazole results in increased expression of TH protein
Misonidazole results in increased activity of TH protein		 CTD PMID:2875048 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          carbon atom 19802
            organic molecular entity 19775
              misonidazole 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            misonidazole 6
paths to the root