The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
PNU-282987 is a potent alpha7 nicotinic acetylcholine receptor (nAChR) agonist. PNU-282987 is also a functional antagonist of the 5-HT3 receptor. PNU-282987 can be used for the research of central and peripheral nervous systems.
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]; [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein]; [[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of GSK3B protein; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium; Bungarotoxins inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]; Bungarotoxins inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]; JAK2 protein affects the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]; Mecamylamine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]; methyllycaconitine inhibits the reaction [[[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] co-treated with [PNU-282987 binds to and results in increased activity of CHRNA7 protein]] results in increased uptake of Calcium]; methyllycaconitine inhibits the reaction [PNU-282987 binds to and results in increased activity of CHRNA7 protein]; PNU-282987 inhibits the reaction [epibatidine binds to CHRNA7 protein] PNU-282987 results in increased activity of CHRNA7 protein
[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of GSK3B protein
PNU-282987 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; PNU-282987 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
[1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea affects the activity of CHRNA7 protein] inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein]; [PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of JAK2 protein; JAK2 protein affects the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]
[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]
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