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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carotenol
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Accession:CHEBI:23045 term browser browse the term
Synonyms:related_synonym: carotenols;   hydroxycarotenoids


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9'-cis-neoxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO neoxanthin affects the localization of AIFM1 protein CTD PMID:17186379 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Casp3 caspase 3 multiple interactions ISO neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:17186379 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO neoxanthin results in increased activity of CASP8 protein CTD PMID:17186379 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:17186379 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
all-trans-neoxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO neoxanthin affects the localization of AIFM1 protein CTD PMID:17186379 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Casp3 caspase 3 multiple interactions ISO neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:17186379 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO neoxanthin results in increased activity of CASP8 protein CTD PMID:17186379 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:17186379 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
astaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA] CTD PMID:16964424 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] CTD PMID:16964424 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G C1qa complement C1q A chain decreases expression ISO astaxanthine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G Cat catalase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA] CTD PMID:16964424 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cntd1 cyclin N-terminal domain containing 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA] CTD PMID:16964424 NCBI chr10:89,199,988...89,210,369
Ensembl chr10:89,199,880...89,209,393
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA] CTD PMID:16964424 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA] CTD PMID:16964424 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA] CTD PMID:16964424 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA] CTD PMID:16964424 NCBI chr 1:89,075,987...89,084,834
Ensembl chr 1:89,075,975...89,084,859
Ensembl chr 2:89,075,975...89,084,859
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA] CTD PMID:16964424 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Ctss cathepsin S decreases expression ISO astaxanthine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
EXP astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]]
astaxanthine results in decreased expression of NOX2 mRNA
CTD PMID:23272707 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein
astaxanthine results in increased expression of CYP1A1 mRNA
CTD PMID:21414371 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] CTD PMID:16964424 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP astaxanthine results in increased activity of G6PD protein
[Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein
CTD PMID:28665548, PMID:29975440 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO astaxanthine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
ISO astaxanthine results in increased expression of GJA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]
CTD PMID:16091010 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gna13 G protein subunit alpha 13 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA] CTD PMID:16964424 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA] CTD PMID:16964424 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]] CTD PMID:23538867 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grn granulin precursor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA] CTD PMID:16964424 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:29975440 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions
increases expression
ISO [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA
astaxanthine results in increased expression of GSTM2 mRNA
CTD PMID:24157545 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA] CTD PMID:16964424 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
EXP
ISO
astaxanthine results in increased expression of HMOX1 protein
astaxanthine results in decreased expression of HMOX1 mRNA
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]
astaxanthine results in increased expression of HMOX1 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA
CTD PMID:20038455, PMID:23272707, PMID:24157545 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxa9 homeobox A9 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA] CTD PMID:16964424
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA] CTD PMID:16964424 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein CTD PMID:21621527 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO astaxanthine results in decreased expression of IL6 mRNA CTD PMID:21621527 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lepr leptin receptor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA] CTD PMID:16964424 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA] CTD PMID:16964424 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA] CTD PMID:16964424 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA] CTD PMID:16964424 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA] CTD PMID:16964424 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
EXP
ISO
astaxanthine results in increased expression of NFE2L2 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]]
astaxanthine results in increased expression of NFE2L2 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA
CTD PMID:20038455, PMID:23272707, PMID:24157545 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] CTD PMID:16964424 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP
ISO
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 protein
CTD PMID:20038455, PMID:24157545 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO astaxanthine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity EXP astaxanthine results in increased activity of PGD protein CTD PMID:28665548, PMID:29975440 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Por cytochrome p450 oxidoreductase decreases activity
increases expression
EXP astaxanthine results in decreased activity of POR protein
astaxanthine results in increased expression of POR protein
CTD PMID:21414371 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA] CTD PMID:16964424 NCBI chr 6:23,548,507...23,581,136
Ensembl chr 6:23,549,317...23,581,052
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA] CTD PMID:16964424 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO astaxanthine results in decreased expression of PTGS2 mRNA CTD PMID:21621527 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rps2 ribosomal protein S2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA] CTD PMID:16964424 NCBI chr10:14,088,171...14,090,020
Ensembl chr10:14,088,319...14,089,979
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO astaxanthine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA] CTD PMID:16964424 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]] CTD PMID:23538867 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] CTD PMID:16964424 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA] CTD PMID:16964424 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tkt transketolase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA] CTD PMID:16964424 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO astaxanthine results in decreased expression of TNF protein CTD PMID:21621527 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein] CTD PMID:20038455 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ubb ubiquitin B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] CTD PMID:16964424 NCBI chr10:48,880,231...48,881,896
Ensembl chr10:48,881,049...48,881,881
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA] CTD PMID:16964424 NCBI chr 7:71,264,501...71,269,869
Ensembl chr 7:71,264,514...71,269,869
Ensembl chr 1:71,264,514...71,269,869
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
JBrowse link
fucoxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO fucoxanthin results in increased expression of ACOX1 mRNA CTD PMID:20519145 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of AKT1 protein] CTD PMID:26418808 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein] CTD PMID:20594983 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO fucoxanthin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein]
CTD PMID:20594983 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein] CTD PMID:20594983 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in decreased activity of CAT protein] CTD PMID:26418808 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Drd3 dopamine receptor D3 increases activity ISO fucoxanthin results in increased activity of DRD3 protein CTD PMID:31323226 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 increases activity ISO fucoxanthin results in increased activity of DRD4 protein CTD PMID:31323226 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Flg filaggrin decreases expression ISO fucoxanthin results in decreased expression of FLG mRNA CTD PMID:27590588 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO fucoxanthin results in increased expression of GJA1 mRNA; fucoxanthin results in increased expression of GJA1 protein CTD PMID:19737546 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO fucoxanthin results in increased expression of GJB1 mRNA; fucoxanthin results in increased expression of GJB1 protein CTD PMID:19737546 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO fucoxanthin results in decreased activity of HMGCR protein CTD PMID:20519145 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
fucoxanthin results in increased expression of HMOX1 protein CTD PMID:23358145 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22735499 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22735499 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO fucoxanthin results in decreased activity of MAOA protein CTD PMID:31323226 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO fucoxanthin results in decreased activity of MAOB protein CTD PMID:31323226 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK1 protein] CTD PMID:26418808 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK3 protein] CTD PMID:26418808 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein] CTD PMID:22735499, PMID:26418808 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO fucoxanthin results in increased expression of PPARA mRNA CTD PMID:20519145 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO fucoxanthin results in decreased expression of PPARG mRNA CTD PMID:20519145 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein] CTD PMID:22735499, PMID:26418808 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Retn resistin decreases expression ISO fucoxanthin results in decreased expression of RETN protein CTD PMID:20519145 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22735499 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
lutein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of ALS2 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of ALS2 mRNA
Lutein results in decreased expression of ALS2 mRNA
CTD PMID:24865317 NCBI chr 9:65,961,361...66,034,396
Ensembl chr 9:65,961,346...66,033,871
JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO [Cisplatin co-treated with Lutein] results in increased expression of APC mRNA CTD PMID:24865317 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Aqr aquarius intron-binding spliceosomal factor decreases expression
multiple interactions
ISO Lutein results in decreased expression of AQR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of AQR mRNA
CTD PMID:24865317 NCBI chr 3:105,570,399...105,640,431
Ensembl chr 3:105,570,292...105,640,463
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA
Lutein results in decreased expression of ATR mRNA
CTD PMID:24865317 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Lutein results in increased expression of BAX protein CTD PMID:17455471 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Lutein results in decreased expression of BCL2 protein CTD PMID:17455471 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Lutein results in increased expression of BCL2L1 protein CTD PMID:10750663 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bco2 beta-carotene oxygenase 2 increases metabolic processing
affects metabolic processing
multiple interactions
ISO BCO2 protein results in increased metabolism of Lutein
BCO2 protein affects the metabolism of Lutein
[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite
CTD PMID:21106934 NCBI chr 8:54,965,577...54,990,604
Ensembl chr 8:54,965,583...54,998,864
JBrowse link
G Cat catalase multiple interactions ISO Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein] CTD PMID:20347963 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Lutein results in decreased expression of CCND1 protein CTD PMID:17718427 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Lutein results in increased expression of CCS mRNA CTD PMID:24865317 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
JBrowse link
G Cfd complement factor D decreases expression
decreases secretion
ISO Lutein results in decreased expression of CFD mRNA
Lutein results in decreased secretion of CFD protein
CTD PMID:26504594 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Ctsb cathepsin B increases expression
multiple interactions
ISO Lutein results in increased expression of CTSB mRNA
Cisplatin inhibits the reaction [Lutein results in increased expression of CTSB mRNA]
CTD PMID:24865317 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA
Lutein results in decreased expression of CYBA mRNA
CTD PMID:24865317 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression
multiple interactions
ISO Lutein results in decreased expression of ERCC2 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of ERCC2 mRNA
CTD PMID:24865317 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor decreases expression ISO Lutein results in decreased expression of ERCC6 mRNA CTD PMID:24865317 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 decreases expression ISO Lutein results in decreased expression of FMO2 mRNA CTD PMID:24865317 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Gab1 GRB2-associated binding protein 1 decreases expression
multiple interactions
ISO Lutein results in decreased expression of GAB1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA
CTD PMID:24865317 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA] CTD PMID:22040935, PMID:24865317 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA CTD PMID:24865317 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA CTD PMID:24865317 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO Lutein results in increased expression of GSR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GSR mRNA
CTD PMID:24865317 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of GSTK1 mRNA CTD PMID:24865317 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Lutein results in increased expression of HMOX1 mRNA; Lutein results in increased expression of HMOX1 protein
CTD PMID:25815309, PMID:26187899 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of IDH1 mRNA
Lutein results in decreased expression of IDH1 mRNA
CTD PMID:24865317 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Ift172 intraflagellar transport 172 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA
Lutein results in decreased expression of IFT172 mRNA
CTD PMID:24865317 NCBI chr 6:26,390,686...26,485,459 JBrowse link
G Kif9 kinesin family member 9 multiple interactions
increases expression
ISO Lutein promotes the reaction [Cisplatin results in decreased expression of KIF9 mRNA]
Lutein results in increased expression of KIF9 mRNA
CTD PMID:24865317 NCBI chr 8:118,737,739...118,795,190
Ensembl chr 8:118,744,229...118,794,992
JBrowse link
G Mb myoglobin increases expression ISO Lutein results in increased expression of MB mRNA CTD PMID:24865317 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA] CTD PMID:25815309, PMID:26187899 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]; Lutein results in increased expression of and affects the localization of NFE2L2 protein
Lutein results in increased expression of NFE2L2 mRNA; Lutein results in increased expression of NFE2L2 protein
CTD PMID:25815309, PMID:26187899 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngb neuroglobin increases expression ISO Lutein results in increased expression of NGB mRNA CTD PMID:24865317 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of NOX4 mRNA
Lutein results in decreased expression of NOX4 mRNA
CTD PMID:24865317 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of NOXO1 mRNA CTD PMID:24865317 NCBI chr10:14,062,331...14,066,918
Ensembl chr10:14,062,331...14,066,918
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO [Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 protein]
Lutein results in increased expression of NQO1 mRNA; Lutein results in increased expression of NQO1 protein
CTD PMID:24865317, PMID:25815309, PMID:26187899 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nudt15 nudix hydrolase 15 decreases expression
multiple interactions
ISO Lutein results in decreased expression of NUDT15 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of NUDT15 mRNA
CTD PMID:24865317 NCBI chr15:55,417,774...55,456,698
Ensembl chr15:55,419,502...55,456,698
JBrowse link
G Nxn nucleoredoxin increases expression
multiple interactions
ISO Lutein results in increased expression of NXN mRNA
Lutein inhibits the reaction [Cisplatin results in increased expression of NXN mRNA]
CTD PMID:24865317 NCBI chr10:64,411,710...64,550,147
Ensembl chr10:64,412,833...64,550,145
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA CTD PMID:24865317 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of PPP1R15B mRNA
Lutein results in decreased expression of PPP1R15B mRNA
CTD PMID:24865317 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Prdx4 peroxiredoxin 4 increases expression ISO Lutein results in increased expression of PRDX4 mRNA CTD PMID:24865317 NCBI chr  X:43,495,453...43,512,994
Ensembl chr  X:43,497,763...43,512,991
JBrowse link
G Prdx5 peroxiredoxin 5 decreases expression ISO Lutein results in decreased expression of PRDX5 mRNA CTD PMID:24865317 NCBI chr 1:222,164,462...222,167,447
Ensembl chr 1:222,164,462...222,167,447
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of PRDX6 mRNA
Lutein results in decreased expression of PRDX6 mRNA
CTD PMID:24865317 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA CTD PMID:24865317 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein] CTD PMID:20347963 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]; Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein] CTD PMID:20347963 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SCD1 mRNA
Lutein results in decreased expression of SCD1 mRNA
CTD PMID:24865317 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD1 mRNA]
Lutein results in increased expression of SOD1 mRNA
CTD PMID:22040935, PMID:24865317 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]
Lutein results in decreased expression of SOD2 mRNA
CTD PMID:22040935, PMID:24865317 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA
Lutein results in decreased expression of SOD3 mRNA
CTD PMID:24865317 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SRXN1 mRNA
Lutein results in decreased expression of SRXN1 mRNA
CTD PMID:24865317 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression
multiple interactions
ISO Lutein results in decreased expression of TXNRD1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA
CTD PMID:24865317 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ucp3 uncoupling protein 3 increases expression ISO Lutein results in increased expression of UCP3 mRNA CTD PMID:24865317 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Vim vimentin increases expression ISO Lutein results in increased expression of VIM mRNA CTD PMID:24865317 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 increases expression ISO Lutein results in increased expression of XIRP1 mRNA CTD PMID:24865317 NCBI chr 8:128,694,809...128,712,092
Ensembl chr 8:128,702,133...128,711,221
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      atom 19788
        nonmetal atom 19662
          carbon atom 19560
            organic molecular entity 19560
              isoprenoid 9607
                terpenoid 9591
                  tetraterpenoid 412
                    carotenoid 412
                      xanthophyll 154
                        carotenol 119
                          (3E)-3,4-didehydrorhodopin 0
                          (3R,6'R)-3-hydroxy-3',4'-didehydro-beta,gamma-carotene 0
                          1'-hydroxy-demethylspheroidene 0
                          1'-hydroxy-gamma-carotene 0
                          1'-hydroxytorulene 0
                          1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene 0
                          1,1'-dihydroxy-3,4-didehydrolycopene 0
                          1,1'-dihydroxyneurosporene 0
                          15,15'-dihydroxy-beta-carotene 0
                          2',2'-dihydroxy-2-oxospirilloxanthin 0
                          2'-hydroxy-2-oxospirilloxanthin 0
                          2,2-dihydroxyspheroidene 0
                          2,2-dihydroxyspirilloxanthin 0
                          2-hydroxyspheroidene 0
                          2-hydroxyspirilloxanthin 0
                          3,1'-dihydroxy-gamma-carotene 0
                          alpha-cryptoxanthin 0
                          astaxanthin 56
                          beta-cryptoxanthin + 0
                          chloroxanthin 0
                          demethylspheroidene + 0
                          epoxycarotenol + 28
                          lutein + 53
                          lycophyll 0
                          lycoxanthin 0
                          meso-zeaxanthin 0
                          parasiloxanthin 0
                          rhodopin + 0
                          rhodopinol 0
                          rubixanthin 0
                          tunaxanthin + 0
                          zeaxanthin + 0
                          zeinoxanthin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19420
                        hydrogen molecular entity 19411
                          hydrides 18460
                            organic hydride 17773
                              organic fundamental parent 17773
                                hydrocarbon 17294
                                  terpene 9607
                                    tetraterpene 412
                                      carotene 412
                                        carotenoid 412
                                          xanthophyll 154
                                            carotenol 119
                                              (3E)-3,4-didehydrorhodopin 0
                                              (3R,6'R)-3-hydroxy-3',4'-didehydro-beta,gamma-carotene 0
                                              1'-hydroxy-demethylspheroidene 0
                                              1'-hydroxy-gamma-carotene 0
                                              1'-hydroxytorulene 0
                                              1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene 0
                                              1,1'-dihydroxy-3,4-didehydrolycopene 0
                                              1,1'-dihydroxyneurosporene 0
                                              15,15'-dihydroxy-beta-carotene 0
                                              2',2'-dihydroxy-2-oxospirilloxanthin 0
                                              2'-hydroxy-2-oxospirilloxanthin 0
                                              2,2-dihydroxyspheroidene 0
                                              2,2-dihydroxyspirilloxanthin 0
                                              2-hydroxyspheroidene 0
                                              2-hydroxyspirilloxanthin 0
                                              3,1'-dihydroxy-gamma-carotene 0
                                              alpha-cryptoxanthin 0
                                              astaxanthin 56
                                              beta-cryptoxanthin + 0
                                              chloroxanthin 0
                                              demethylspheroidene + 0
                                              epoxycarotenol + 28
                                              lutein + 53
                                              lycophyll 0
                                              lycoxanthin 0
                                              meso-zeaxanthin 0
                                              parasiloxanthin 0
                                              rhodopin + 0
                                              rhodopinol 0
                                              rubixanthin 0
                                              tunaxanthin + 0
                                              zeaxanthin + 0
                                              zeinoxanthin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.