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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:verrucarin A
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Accession:CHEBI:230243 term browser browse the term
Definition:A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.
Synonyms:exact_synonym: (4S,5R,10E,12Z,16R,16aS,17S,18R,19aR,23aR)-4-hydroxy-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,9,14-trione
 related_synonym: Formula=C27H34O9;   InChI=1S/C27H34O9/c1-16-8-10-26-14-33-24(31)23(30)17(2)9-11-32-21(28)6-4-5-7-22(29)36-18-13-20(35-19(26)12-16)27(15-34-27)25(18,26)3/h4-7,12,17-20,23,30H,8-11,13-15H2,1-3H3/b6-4+,7-5-/t17-,18-,19-,20-,23+,25-,26-,27+/m1/s1;   InChIKey=NLUGUZJQJYVUHS-IDXDZYHTSA-N;   Muconomycin A;   SMILES=[H][C@]12C[C@H]3OC(=O)\\C=C/C=C/C(=O)OCC[C@@H](C)[C@H](O)C(=O)OC[C@@]4(CCC(C)=C[C@@]4([H])O1)[C@]3(C)[C@]21CO1
 alt_id: CHEBI:9968
 xref: Beilstein:1612598;   CAS:3148-09-2;   KEGG:C09746;   KNApSAcK:C00003200
 xref_mesh: MESH:C005348


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verrucarin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 increases expression
affects secretion
ISO muconomycin A results in increased expression of IL2 mRNA
muconomycin A affects the secretion of IL2 protein
CTD PMID:8560498 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 affects secretion
increases expression
ISO muconomycin A affects the secretion of IL4 protein
muconomycin A results in increased expression of IL4 mRNA
CTD PMID:8560498 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 affects secretion ISO muconomycin A affects the secretion of IL5 protein CTD PMID:8560498 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression ISO muconomycin A results in increased expression of IL6 mRNA CTD PMID:8560498 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          macrolide antibiotic 392
            verrucarin A 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        lactone 5978
                                          macrocyclic lactone 1730
                                            macrolide 1597
                                              macropolylide 170
                                                macrotriolide 4
                                                  verrucarin A 4
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