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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:canadine
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Accession:CHEBI:22998 term browser browse the term
Definition:A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10.
Synonyms:exact_synonym: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline
 related_synonym: 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine;   5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo(g)benzo-1,3-dioxolo(5,6-a)quinolizine;   9,10-dimethoxy-2,3-(methylenedioxy)berbine;   Canadin;   Formula=C20H21NO4;   InChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3;   InChIKey=VZTUIEROBZXUFA-UHFFFAOYSA-N;   SMILES=COc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC;   tetrahydroberberine;   xanthopuccine
 xref: Beilstein:96683;   CAS:522-97-4;   LINCS:LSM-21633
 xref_mesh: MESH:C004645
 xref: PMID:23747414;   PMID:24324259;   PMID:25093987;   Reaxys:96683;   Wikipedia:Canadine


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canadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO canadine results in increased expression of CYP1A2 mRNA; canadine results in increased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO canadine results in increased expression of CYP2E1 mRNA; canadine results in increased expression of CYP2E1 protein CTD PMID:28257954 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          metabolite 19286
            alkaloid 5635
              isoquinoline alkaloid 1136
                berberine alkaloid 360
                  canadine 2
                    (R)-canadine 0
                    (S)-canadine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  organonitrogen heterocyclic compound 17523
                                    dibenzoquinolizine 360
                                      berberine alkaloid 360
                                        canadine 2
                                          (R)-canadine 0
                                          (S)-canadine + 0
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