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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butenoic acid
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Accession:CHEBI:22959 term browser browse the term
Definition:Any C4, straight-chain fatty acid containing one double bond.
Synonyms:related_synonym: Formula=C4H6O2
 xref: DrugBank:DB02074


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mevinphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein] CTD PMID:4859365, PMID:8783813, PMID:21251949 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions
EXP Mevinphos results in increased expression of AGTR1A mRNA; Mevinphos results in increased expression of AGTR1A protein
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]
CTD PMID:23824088 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
EXP [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid
Mevinphos results in increased expression of AGTR2 mRNA; Mevinphos results in increased expression of AGTR2 protein
CTD PMID:23824088 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP Mevinphos results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein; PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]
CTD PMID:24462917, PMID:25449601 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein] CTD PMID:21390240 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation EXP Mevinphos results in increased phosphorylation of ATF2 protein CTD PMID:23157661 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
EXP HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein] CTD PMID:17150954 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
EXP Mevinphos affects the expression of BCL2 protein
HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]
CTD PMID:17150954 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Mevinphos results in increased activity of CASP3 protein
HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]
CTD PMID:17150954 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cep55 centrosomal protein 55 increases expression EXP Mevinphos results in increased expression of CEP55 mRNA; Mevinphos results in increased expression of CEP55 protein CTD PMID:25449601 NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases activity EXP Mevinphos results in increased activity of CHRM2 protein CTD PMID:17395621 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 increases activity EXP Mevinphos results in increased activity of CHRM4 protein CTD PMID:17395621 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos promotes the reaction [HIF1A protein binds to ARNT protein]; Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; Mevinphos results in increased expression of and affects the localization of HIF1A protein; Mevinphos results in increased expression of and results in increased activity of HIF1A protein; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein]; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:19333137, PMID:21390240 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Mevinphos results in increased expression of HMOX1 protein
HIF1A protein affects the reaction [Mevinphos results in increased expression of HMOX1 protein]
CTD PMID:19333137 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression EXP Mevinphos results in increased expression of HSPA9 protein CTD PMID:17150954 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
EXP HSPD1 protein affects the reaction [Mevinphos affects the expression of BAX protein]; HSPD1 protein affects the reaction [Mevinphos affects the expression of BCL2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased activity of CASP3 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; Mevinphos affects the reaction [HSPD1 protein binds to BCL2 protein]; Mevinphos promotes the reaction [HSPD1 protein binds to BAX protein]
Mevinphos results in increased expression of HSPD1 mRNA; Mevinphos results in increased expression of HSPD1 protein
CTD PMID:17150954 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Mevinphos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP Mevinphos results in increased phosphorylation of JUN protein CTD PMID:23157661 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases phosphorylation EXP Mevinphos results in increased phosphorylation of MAP2K4 protein CTD PMID:23157661 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation EXP Mevinphos results in increased phosphorylation of MAP2K6 protein CTD PMID:23157661 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]; Mevinphos affects the localization of and affects the activity of NFKB1 protein; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases activity
increases expression
EXP ARNT protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS1 protein]; KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]
Mevinphos results in increased activity of NOS1 protein
Mevinphos results in increased expression of NOS1 mRNA; Mevinphos results in increased expression of NOS1 protein
CTD PMID:15111025, PMID:15617736, PMID:17150954, PMID:17395621, PMID:17438462, PMID:21390240, PMID:24462917, PMID:28601397 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases activity
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein]; methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
Mevinphos results in increased activity of NOS2 protein
Mevinphos results in increased expression of NOS2; Mevinphos results in increased expression of NOS2 mRNA; Mevinphos results in increased expression of NOS2 protein
CTD PMID:15111025, PMID:15617736, PMID:17150954, PMID:17395621, PMID:21390240, PMID:24462917, PMID:25449601, PMID:28601397 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases phosphorylation
multiple interactions
EXP Mevinphos results in increased phosphorylation of PIK3R1 protein
PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]
CTD PMID:24462917 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases expression
EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; 7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]; ARNT protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HIF1A protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]; HSPD1 protein affects the reaction [Mevinphos results in increased expression of PRKG1 protein]
Mevinphos results in increased expression of PRKG1 mRNA; Mevinphos results in increased expression of PRKG1 protein
CTD PMID:15617736, PMID:17150954, PMID:21390240, PMID:28601397 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA]; PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:28601397 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
EXP AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein]; methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Mevinphos affects the localization of and affects the activity of RELA protein; PIK3R1 protein affects the reaction [Mevinphos results in increased activity of RELA protein]; triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Tropicamide inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:17395621, PMID:24462917 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions EXP Mevinphos promotes the reaction [HIF1A protein binds to SUMO1 protein]; SUMO1 protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP Mevinphos results in increased expression of and results in increased activity of UBE2I protein; UBE2I protein affects the reaction [Mevinphos results in increased expression of and results in increased activity of HIF1A protein] CTD PMID:21390240 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions
increases expression
EXP Cycloheximide inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein]; Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein] CTD PMID:15545831 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          carbon atom 19561
            organic molecular entity 19561
              lipid 16976
                fatty acid 15844
                  short-chain fatty acid 15498
                    butenoic acid 31
                      2-butenoic acid + 31
                      O-butenoyl-L-carnitine + 0
                      O-butenoylcarnitine + 0
                      but-3-enoic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          fatty acid 15844
                                            unsaturated fatty acid 922
                                              monounsaturated fatty acid 420
                                                butenoic acid 31
                                                  2-butenoic acid + 31
                                                  O-butenoyl-L-carnitine + 0
                                                  O-butenoylcarnitine + 0
                                                  but-3-enoic acid + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.