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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butanone
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Accession:CHEBI:22951 term browser browse the term
Definition:Any ketone that is butane substituted by an oxo group at unspecified position.
Synonyms:related_synonym: butanones



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butan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 decreases expression ISO methylethyl ketone results in decreased expression of CACNG6 mRNA CTD PMID:33064461 NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance ISO CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone CTD PMID:21352904 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO
EXP
methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO methylethyl ketone results in increased expression of PPARGC1A mRNA CTD PMID:33064461 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases expression ISO methylethyl ketone results in decreased expression of SRSF2 mRNA CTD PMID:33064461 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
buten-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form CTD PMID:29618714 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO 3-buten-2-one binds to and results in decreased activity of GAPDH protein CTD PMID:22084934 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one CTD PMID:11524419 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
Malabaricone C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor multiple interactions ISO malabaricone C promotes the reaction [Indomethacin results in increased expression of EGFR protein] CTD PMID:17977527 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein] CTD PMID:17977527 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS2 protein] CTD PMID:17977527 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      group 19744
        inorganic group 19267
          oxo group 18678
            organic oxo compound 18678
              carbonyl compound 18678
                ketone 16926
                  butanone 11
                    1,1-dihydroxy-3-ethoxy-2-butanone 0
                    1-(2,4-dihydroxyphenyl)heptane-1,2-dione 0
                    1-(2-naphthalenyl)hexane-1,4-dione 0
                    3,3-dimethyl-1-(methylsulfanyl)butan-2-one + 0
                    5-Dihydrobenzofuranpyrovalerone 0
                    Butroxydim 0
                    Dihydronaringenin-O-sulphate 0
                    Hofmeisterin II 0
                    Malabaricone C 3
                    Marianin B 0
                    Yungensin C 0
                    butan-2-one + 8
                    florantyrone 0
                    menbutone 0
                    multifidol + 0
                    multifidol glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      ketone 16926
                                        butanone 11
                                          1,1-dihydroxy-3-ethoxy-2-butanone 0
                                          1-(2,4-dihydroxyphenyl)heptane-1,2-dione 0
                                          1-(2-naphthalenyl)hexane-1,4-dione 0
                                          3,3-dimethyl-1-(methylsulfanyl)butan-2-one + 0
                                          5-Dihydrobenzofuranpyrovalerone 0
                                          Butroxydim 0
                                          Dihydronaringenin-O-sulphate 0
                                          Hofmeisterin II 0
                                          Malabaricone C 3
                                          Marianin B 0
                                          Yungensin C 0
                                          butan-2-one + 8
                                          florantyrone 0
                                          menbutone 0
                                          multifidol + 0
                                          multifidol glucoside 0
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