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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:butanone
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Accession:CHEBI:22951 term browser browse the term
Definition:Any ketone that is butane substituted by an oxo group at unspecified position.
Synonyms:related_synonym: butanones


show annotations for term's descendants           Sort by:
butan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 decreases expression ISO methylethyl ketone results in decreased expression of CACNG6 mRNA CTD PMID:33064461 NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance ISO CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone CTD PMID:21352904 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO
EXP		 methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO methylethyl ketone results in increased expression of PPARGC1A mRNA CTD PMID:33064461 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases expression ISO methylethyl ketone results in decreased expression of SRSF2 mRNA CTD PMID:33064461 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338 		JBrowse link
buten-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form CTD PMID:29618714 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO 3-buten-2-one binds to and results in decreased activity of GAPDH protein CTD PMID:22084934 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one CTD PMID:11524419 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
Malabaricone C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor multiple interactions ISO malabaricone C promotes the reaction [Indomethacin results in increased expression of EGFR protein] CTD PMID:17977527 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein] CTD PMID:17977527 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS2 protein] CTD PMID:17977527 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      group 19888
        inorganic group 19460
          oxo group 18945
            organic oxo compound 18945
              carbonyl compound 18945
                ketone 17194
                  butanone 11
                    (2R)-2-hydroxy-1-(8-hydroxy-3-methylisoquinolin-7-yl)-3-methylbutan-1-one 0
                    1,1-dihydroxy-3-ethoxy-2-butanone 0
                    1-(2,4-dihydroxyphenyl)heptane-1,2-dione 0
                    1-(2-naphthalenyl)hexane-1,4-dione 0
                    1-(benzo[d][1,3]dioxol-4-yl)-2-(methylamino)pentan-1-one 0
                    1-epi-paeciloketal B 0
                    3,3-dimethyl-1-(methylsulfanyl)butan-2-one + 0
                    4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-oxobutanoic acid 0
                    4-hydroxy-6-me~hoxy-5-(l'-oxobutyl)benzo[b]dihydrofuran 0
                    5-Dihydrobenzofuranpyrovalerone 0
                    Asperisocoumarin E 0
                    Butroxydim 0
                    Butylone 0
                    Dibutylone 0
                    Dihydronaringenin-O-sulphate 0
                    Ent-paeciloketal A 0
                    Hofmeisterin II 0
                    Malabaricone C 3
                    Marianin B 0
                    Ovalitenin B 0
                    Paeciloketal A 0
                    Paeciloketal B 0
                    Paecilospirone 0
                    Yungensin C 0
                    beta-Hydroxy-2',6'-dimethoxy-3',4'-methylenedioxydihydrochalcone 0
                    butan-2-one + 8
                    florantyrone 0
                    menbutone 0
                    multifidol + 0
                    multifidol glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbonyl compound 18945
                                    ketone 17194
                                      butanone 11
                                        (2R)-2-hydroxy-1-(8-hydroxy-3-methylisoquinolin-7-yl)-3-methylbutan-1-one 0
                                        1,1-dihydroxy-3-ethoxy-2-butanone 0
                                        1-(2,4-dihydroxyphenyl)heptane-1,2-dione 0
                                        1-(2-naphthalenyl)hexane-1,4-dione 0
                                        1-(benzo[d][1,3]dioxol-4-yl)-2-(methylamino)pentan-1-one 0
                                        1-epi-paeciloketal B 0
                                        3,3-dimethyl-1-(methylsulfanyl)butan-2-one + 0
                                        4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-oxobutanoic acid 0
                                        4-hydroxy-6-me~hoxy-5-(l'-oxobutyl)benzo[b]dihydrofuran 0
                                        5-Dihydrobenzofuranpyrovalerone 0
                                        Asperisocoumarin E 0
                                        Butroxydim 0
                                        Butylone 0
                                        Dibutylone 0
                                        Dihydronaringenin-O-sulphate 0
                                        Ent-paeciloketal A 0
                                        Hofmeisterin II 0
                                        Malabaricone C 3
                                        Marianin B 0
                                        Ovalitenin B 0
                                        Paeciloketal A 0
                                        Paeciloketal B 0
                                        Paecilospirone 0
                                        Yungensin C 0
                                        beta-Hydroxy-2',6'-dimethoxy-3',4'-methylenedioxydihydrochalcone 0
                                        butan-2-one + 8
                                        florantyrone 0
                                        menbutone 0
                                        multifidol + 0
                                        multifidol glucoside 0
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