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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:butanediols
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Accession:CHEBI:22944 term browser browse the term
Definition:A diol that is a butanediol or a derivative of a butanediol.

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(-)-secoisolariciresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO secoisolariciresinol results in increased activity of NR1I2 protein CTD PMID:15885729 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824 		JBrowse link
1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO [Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr 1:134,199,215...134,235,457
Ensembl chr 1:134,199,223...134,235,431 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions
increases activity		 EXP
ISO		 Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]		 CTD PMID:2061546 PMID:20472051 PMID:21360559 PMID:21910133 PMID:22180340 PMID:23933410 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions ISO Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]] CTD PMID:6323860 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215 		JBrowse link
G As3mt arsenite methyltransferase multiple interactions
increases reduction		 ISO Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]		 CTD PMID:15025511 PMID:25349987 NCBI chr19:46,707,157...46,741,099
Ensembl chr19:46,707,458...46,741,099 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Dithiothreitol results in increased expression of ATF3 mRNA CTD PMID:17332266 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO
EXP		 Dithiothreitol results in increased expression of ATF4 mRNA CTD PMID:27226639 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541 		JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:18022205 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Calu calumenin increases expression ISO Dithiothreitol results in increased expression of CALU protein CTD PMID:21692457 NCBI chr 6:29,348,106...29,376,675
Ensembl chr 6:29,348,069...29,377,110 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 [Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]		 CTD PMID:9388267 PMID:9441900 PMID:9706149 PMID:9755104 PMID:10673743 PMID:11226294 PMID:26124276 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein] CTD PMID:11226294 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977 PMID:32493877 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]] CTD PMID:21256830 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Dithiothreitol results in decreased expression of CCND1 mRNA CTD PMID:17332266 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Dithiothreitol results in increased expression of CCNG2 mRNA CTD PMID:17332266 NCBI chr 5:93,267,573...93,276,231
Ensembl chr 5:93,267,257...93,276,231 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] CTD PMID:16280210 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 increases activity ISO Dithiothreitol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO
EXP		 Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]		 CTD PMID:17332266 PMID:27226639 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions ISO Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein CTD PMID:12486162 NCBI chr 3:58,525,821...58,557,501
Ensembl chr 3:58,525,821...58,557,501 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein		 CTD PMID:12486162 PMID:25321315 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation
multiple interactions		 EXP Dithiothreitol results in increased phosphorylation of EIF2S1 protein
EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:30385349 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010 		JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions
increases expression		 ISO Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein		 CTD PMID:12486162 PMID:25321315 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein] CTD PMID:22403704 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614 		JBrowse link
G F3 coagulation factor III increases activity ISO Dithiothreitol results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048 		JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions		 ISO
EXP		 Dithiothreitol results in increased expression of FGF21 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]		 CTD PMID:27226639 NCBI chr 7:45,613,890...45,615,490
Ensembl chr 7:45,613,886...45,615,490 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Dithiothreitol results in increased expression of GADD45A mRNA CTD PMID:17332266 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] CTD PMID:14695184 PMID:17658243 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]		 CTD PMID:24489685 PMID:26111761 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862 PMID:26859423 NCBI chr 8:105,518,746...105,523,988
Ensembl chr 8:105,518,755...105,523,988 		JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein CTD PMID:15710169 PMID:17332266 PMID:17416481 PMID:21692457 PMID:25321315 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]		 CTD PMID:17067557 PMID:20584749 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] CTD PMID:14762100 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106 		JBrowse link
G Il5ra interleukin 5 receptor, alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr 6:106,710,375...106,749,037
Ensembl chr 6:106,710,357...106,749,037 		JBrowse link
G Inhbe inhibin beta-E increases expression ISO Dithiothreitol results in increased expression of INHBE mRNA CTD PMID:22935518 NCBI chr10:127,349,402...127,351,848
Ensembl chr10:127,348,857...127,354,411 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222 		JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24853401 NCBI chr10:127,225,695...127,266,348
Ensembl chr10:127,225,696...127,263,348 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO		 Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]		 CTD PMID:11035063 PMID:23370007 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204 PMID:16386761 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755 		JBrowse link
G Msrb2 methionine sulfoxide reductase B2 increases reduction ISO Dithiothreitol results in increased reduction of MSRB2 protein CTD PMID:16735467 NCBI chr 2:19,371,436...19,394,976
Ensembl chr 2:19,371,440...19,394,976 		JBrowse link
G Msrb3 methionine sulfoxide reductase B3 increases reduction ISO Dithiothreitol results in increased reduction of MSRB3 protein CTD PMID:16735467 NCBI chr10:120,781,100...120,899,011
Ensembl chr10:120,781,096...120,899,101 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327 		JBrowse link
G Nat1 N-acetyl transferase 1 increases activity
multiple interactions		 ISO Dithiothreitol results in increased activity of NAT1 protein
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]		 CTD PMID:22835378 NCBI chr 8:67,490,968...67,492,531
Ensembl chr 8:67,480,921...67,492,104 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein] CTD PMID:24489685 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]		 CTD PMID:9281604 PMID:14762100 PMID:16219905 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO		 Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]		 CTD PMID:17067557 PMID:19509257 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]		 CTD PMID:7532384 PMID:9706149 PMID:9755104 PMID:15907790 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein] CTD PMID:24489685 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]		 CTD PMID:2226332 PMID:2298732 PMID:15250541 PMID:16857225 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421 		JBrowse link
G Nrgn neurogranin multiple interactions ISO Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein] CTD PMID:21241739 NCBI chr 9:37,544,493...37,552,745
Ensembl chr 9:37,544,492...37,552,904 		JBrowse link
G Nudt9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]] CTD PMID:16860484 NCBI chr 5:104,045,538...104,065,378
Ensembl chr 5:104,046,306...104,065,379 		JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr11:6,291,597...6,359,094
Ensembl chr11:6,291,633...6,356,642 		JBrowse link
G P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr 5:110,339,812...110,343,320
Ensembl chr 5:110,339,812...110,343,212 		JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 increases activity ISO Dithiothreitol results in increased activity of PAPSS1 protein CTD PMID:15065880 NCBI chr 3:131,564,764...131,643,671
Ensembl chr 3:131,564,768...131,643,671 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP
ISO		 Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]		 CTD PMID:11035063 PMID:18022205 PMID:20438634 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression ISO Dithiothreitol results in increased expression of PDCD6IP protein CTD PMID:21692457 NCBI chr 9:113,651,744...113,708,279
Ensembl chr 9:113,651,744...113,708,259 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Dithiothreitol results in increased expression of PLOD3 protein CTD PMID:21692457 NCBI chr 5:136,987,019...136,996,646
Ensembl chr 5:136,987,019...136,996,648 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Dithiothreitol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]] CTD PMID:20584749 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]		 CTD PMID:16781456 PMID:32493877 NCBI chr 2:167,930,750...167,979,385
Ensembl chr 2:167,932,057...167,979,385 		JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Dithiothreitol results in increased expression of RCN2 protein CTD PMID:21692457 NCBI chr 9:56,041,845...56,059,083
Ensembl chr 9:56,041,845...56,061,882 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases activity		 ISO
EXP		 Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
Dithiothreitol results in increased activity of RELA protein
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]		 CTD PMID:7491977 PMID:9281604 PMID:16219905 PMID:20351055 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G S100a2 S100 calcium binding protein A2 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Dithiothreitol inhibits the reaction [S100A2 protein binds to S100A2 protein] CTD PMID:21924240 NCBI chr 3:90,590,247...90,591,508
Ensembl chr 3:90,560,363...90,591,531 		JBrowse link
G S100a4 S100 calcium binding protein A4 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045 		JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462 		JBrowse link
G Sod1 superoxide dismutase 1, soluble affects folding
multiple interactions		 ISO
EXP		 Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]		 CTD PMID:22867017 PMID:26694608 PMID:26699812 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases expression		 ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions EXP Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] CTD PMID:26699812 NCBI chr10:127,642,955...127,660,987
Ensembl chr10:127,642,986...127,660,957 		JBrowse link
G Thy1 thymus cell antigen 1, theta multiple interactions EXP Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] CTD PMID:11035063 NCBI chr 9:44,043,384...44,048,579
Ensembl chr 9:44,043,384...44,048,579 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]		 CTD PMID:7476933 PMID:7532384 PMID:9281604 PMID:9388267 PMID:16219905 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein] CTD PMID:17555331 PMID:25446071 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions
increases activity		 ISO Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein		 CTD PMID:21984481 NCBI chr  X:144,377,327...144,688,180
Ensembl chr  X:144,381,671...144,688,180 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein] CTD PMID:19527742 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196 		JBrowse link
busulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenergic receptor, beta 2 decreases response to substance EXP ADRB2 protein results in decreased susceptibility to Busulfan CTD PMID:7202579 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959 		JBrowse link
G Anp32b acidic (leucine-rich) nuclear phosphoprotein 32 family, member B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of ANP32B protein CTD PMID:20933509 NCBI chr 4:46,450,926...46,472,657
Ensembl chr 4:46,450,902...46,472,657 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Busulfan CTD PMID:19470598 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139 		JBrowse link
G Ar androgen receptor multiple interactions ISO Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor (GDI) alpha multiple interactions
affects response to substance		 ISO ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein]
ARHGDIA mRNA affects the susceptibility to Busulfan		 CTD PMID:17264767 NCBI chr11:120,578,099...120,581,624
Ensembl chr11:120,578,104...120,581,624 		JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein CTD PMID:20933509 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740 		JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression ISO Busulfan results in decreased expression of BMP4 mRNA CTD PMID:15786497 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP3 protein; [decitabine co-treated with Busulfan] results in increased activity of CASP3 protein; ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] CTD PMID:17264767 PMID:18339423 PMID:19732952 PMID:20933509 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 ISO Busulfan results in increased activity of CASP8 protein
[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]		 CTD PMID:18339423 PMID:19732952 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP9 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP9 protein] CTD PMID:19732952 PMID:20933509 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein CTD PMID:20933509 NCBI chr 2:131,186,436...131,198,511
Ensembl chr 2:131,186,949...131,198,497 		JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression EXP Busulfan results in decreased expression of CDK2 mRNA CTD PMID:15388331 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Busulfan results in decreased expression of CDK4 mRNA CTD PMID:15388331 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression
multiple interactions		 ISO Busulfan results in increased expression of CDKN1A protein
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of CDKN1A protein		 CTD PMID:16882877 PMID:20933509 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression EXP Busulfan results in increased expression of CDKN2A mRNA CTD PMID:14500376 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein CTD PMID:20933509 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145 		JBrowse link
G Col4a1 collagen, type IV, alpha 1 affects expression EXP Busulfan affects the expression of COL4A1 mRNA CTD PMID:15941629 NCBI chr 8:11,198,423...11,312,889
Ensembl chr 8:11,198,423...11,312,826 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide] CTD PMID:28744217 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions ISO [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide] CTD PMID:28744217 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072 		JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) decreases expression EXP Busulfan results in decreased expression of FASL mRNA CTD PMID:15388331 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495 		JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression ISO Busulfan results in decreased expression of FGF8 mRNA CTD PMID:15786497 NCBI chr19:45,736,491...45,742,941
Ensembl chr19:45,736,798...45,742,915 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor affects expression
increases expression		 EXP Busulfan affects the expression of GDNF mRNA
Busulfan results in increased expression of GDNF mRNA		 CTD PMID:20684317 PMID:22082982 PMID:26524245 NCBI chr15:7,810,048...7,837,580
Ensembl chr15:7,810,846...7,837,575 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression		 EXP Busulfan results in decreased expression of and results in decreased activity of GPX4 protein; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] CTD PMID:32416107 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects metabolic processing
affects abundance
affects response to substance
multiple interactions		 ISO GSTM1 protein affects the metabolism of Busulfan
GSTM1 gene polymorphism affects the abundance of Busulfan
GSTM1 gene polymorphism affects the susceptibility to Busulfan
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan; [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]		 CTD PMID:8886613 PMID:15142875 PMID:19584821 PMID:20672371 PMID:21215809 PMID:28744217 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects abundance
affects metabolic processing		 ISO GSTP1 gene polymorphism affects the abundance of Busulfan
GSTP1 protein affects the metabolism of Busulfan		 CTD PMID:8886613 PMID:20672371 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 multiple interactions ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan CTD PMID:21215809 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO Busulfan results in increased phosphorylation of H2AX protein
[Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein		 CTD PMID:18339423 PMID:20933509 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077 		JBrowse link
G Inhba inhibin beta-A multiple interactions
increases expression		 ISO bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA mRNA]; bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA protein]
Busulfan results in increased expression of INHBA mRNA; Busulfan results in increased expression of INHBA protein		 CTD PMID:12966370 PMID:22286157 NCBI chr13:16,004,256...16,031,609
Ensembl chr13:16,011,851...16,031,621 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Busulfan results in decreased expression of KIT mRNA CTD PMID:15388331 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722 		JBrowse link
G Lama1 laminin, alpha 1 affects expression EXP Busulfan affects the expression of LAMA1 mRNA CTD PMID:15941629 NCBI chr17:67,697,127...67,822,645
Ensembl chr17:67,697,259...67,822,647 		JBrowse link
G Lama4 laminin, alpha 4 affects expression EXP Busulfan affects the expression of LAMA4 mRNA CTD PMID:15941629 NCBI chr10:38,965,515...39,110,188
Ensembl chr10:38,965,515...39,110,188 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases activity ISO Busulfan results in increased activity of MAPK1 protein CTD PMID:16882877 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases activity ISO Busulfan results in increased activity of MAPK3 protein CTD PMID:16882877 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases response to substance ISO MGST2 protein results in decreased susceptibility to Busulfan CTD PMID:15779864 NCBI chr 3:51,636,912...51,682,675
Ensembl chr 3:51,660,360...51,682,677 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of MYC protein CTD PMID:20933509 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374 		JBrowse link
G Nanos2 nanos C2HC-type zinc finger 2 decreases expression EXP Busulfan results in decreased expression of NANOS2 mRNA; Busulfan results in decreased expression of NANOS2 protein CTD PMID:26524245 NCBI chr 7:18,987,524...18,988,962
Ensembl chr 7:18,987,400...18,988,962 		JBrowse link
G Nanos3 nanos C2HC-type zinc finger 3 decreases expression EXP Busulfan results in decreased expression of NANOS3 mRNA CTD PMID:26524245 NCBI chr 8:84,173,733...84,176,552
Ensembl chr 8:84,173,731...84,185,217 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases expression
multiple interactions		 EXP Busulfan results in decreased expression of NFE2L2 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]		 CTD PMID:32416107 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] CTD PMID:20172040 NCBI chr11:33,152,498...33,164,142
Ensembl chr11:33,152,287...33,163,206 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; [decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]
Busulfan results in increased cleavage of PARP1 protein		 CTD PMID:18339423 PMID:19732952 PMID:20933509 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Phb prohibitin affects expression EXP Busulfan affects the expression of PHB mRNA CTD PMID:15388331 NCBI chr11:95,666,957...95,680,773
Ensembl chr11:95,666,957...95,680,773 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Busulfan results in increased expression of PTGS2 mRNA
ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA]		 CTD PMID:12966370 PMID:32416107 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Rad51 RAD51 recombinase decreases expression EXP Busulfan results in decreased expression of RAD51 mRNA CTD PMID:15388331 NCBI chr 2:119,112,814...119,136,073
Ensembl chr 2:119,112,793...119,147,445 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP Busulfan results in decreased phosphorylation of RB1 protein CTD PMID:15388331 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822 		JBrowse link
G Sat2 spermidine/spermine N1-acetyl transferase 2 increases expression EXP Busulfan results in increased expression of SAT2 mRNA; Busulfan results in increased expression of SAT2 protein CTD PMID:28578006 NCBI chr11:69,621,996...69,624,032
Ensembl chr11:69,622,024...69,623,870 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 affects expression ISO Busulfan affects the expression of SERPINC1 protein CTD PMID:15580502 NCBI chr 1:160,978,583...161,002,543
Ensembl chr 1:160,978,585...161,005,863 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression
multiple interactions		 ISO Busulfan results in increased expression of SERPINE1 mRNA; Busulfan results in increased expression of SERPINE1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA]		 CTD PMID:22286157 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268 		JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 decreases expression
multiple interactions		 EXP Busulfan results in decreased expression of SLC40A1 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]		 CTD PMID:32416107 NCBI chr 1:45,908,070...45,926,532
Ensembl chr 1:45,908,068...45,926,523 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein CTD PMID:20933509 NCBI chr  X:152,016,428...152,061,973
Ensembl chr  X:152,016,428...152,062,694 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC3 protein CTD PMID:20933509 NCBI chr19:53,600,396...53,645,831
Ensembl chr19:53,600,398...53,645,833 		JBrowse link
G Stra8 stimulated by retinoic acid gene 8 decreases expression EXP Busulfan results in decreased expression of STRA8 mRNA CTD PMID:15388331 NCBI chr 6:34,920,163...34,939,344
Ensembl chr 6:34,920,163...34,939,344 		JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Busulfan results in decreased expression of TFPI mRNA CTD PMID:22286157 NCBI chr 2:84,432,855...84,476,775
Ensembl chr 2:84,432,855...84,476,775 		JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions		 EXP Busulfan results in decreased expression of TFRC protein
Deferoxamine promotes the reaction [Busulfan results in decreased expression of TFRC protein]		 CTD PMID:32416107 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Busulfan results in increased expression of TGFB1 mRNA CTD PMID:22286157 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Busulfan results in increased expression of THBS1 mRNA CTD PMID:22286157 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Busulfan results in increased expression of TNF mRNA CTD PMID:22286157 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Trf transferrin multiple interactions
increases expression		 ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of TF mRNA]
Busulfan results in increased expression of TF mRNA; Busulfan results in increased expression of TF protein		 CTD PMID:12966370 PMID:22286157 NCBI chr 9:103,208,876...103,230,286
Ensembl chr 9:103,204,001...103,230,444 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Busulfan affects the phosphorylation of and affects the activity of TP53 protein CTD PMID:16882877 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity ISO Busulfan results in decreased activity of TXNRD1 protein CTD PMID:16085187 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein CTD PMID:20933509 NCBI chr  X:42,059,613...42,109,664
Ensembl chr  X:42,059,679...42,109,656 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 increases expression EXP Busulfan results in increased expression of ZBTB16 mRNA CTD PMID:26524245 NCBI chr 9:48,651,797...48,836,225
Ensembl chr 9:48,654,297...48,836,222 		JBrowse link
butane-1,3-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
increases expression		 ISO 1,3-butylene glycol results in increased activity of CYP2E1 protein
1,3-butylene glycol results in increased expression of CYP2E1 protein		 CTD PMID:2919394 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
butane-2,3-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) multiple interactions ISO [AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol CTD PMID:23295224 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950 		JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) multiple interactions ISO [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol CTD PMID:23295224 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial increases metabolic processing ISO ALDH2 protein results in increased metabolism of 2,3-butylene glycol CTD PMID:10064379 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824 		JBrowse link
dithioerythritol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 multiple interactions ISO Dithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein] CTD PMID:23010140 NCBI chr 7:16,781,334...16,798,274
Ensembl chr 7:16,781,340...16,798,274 		JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 multiple interactions ISO Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein] CTD PMID:25490951 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090 		JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions ISO Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]] CTD PMID:19041296 PMID:22900493 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660 		JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 multiple interactions ISO Dithioerythritol inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]
Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein]		 CTD PMID:23402788 PMID:25849418 NCBI chr 9:108,662,136...108,684,642
Ensembl chr 9:108,662,088...108,684,641 		JBrowse link
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO [Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr 1:134,199,215...134,235,457
Ensembl chr 1:134,199,223...134,235,431 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions
increases activity		 EXP
ISO		 Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]		 CTD PMID:2061546 PMID:20472051 PMID:21360559 PMID:21910133 PMID:22180340 PMID:23933410 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions ISO Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]] CTD PMID:6323860 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215 		JBrowse link
G As3mt arsenite methyltransferase multiple interactions
increases reduction		 ISO Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]		 CTD PMID:15025511 PMID:25349987 NCBI chr19:46,707,157...46,741,099
Ensembl chr19:46,707,458...46,741,099 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Dithiothreitol results in increased expression of ATF3 mRNA CTD PMID:17332266 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO
EXP		 Dithiothreitol results in increased expression of ATF4 mRNA CTD PMID:27226639 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541 		JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:18022205 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Calu calumenin increases expression ISO Dithiothreitol results in increased expression of CALU protein CTD PMID:21692457 NCBI chr 6:29,348,106...29,376,675
Ensembl chr 6:29,348,069...29,377,110 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 [Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]		 CTD PMID:9388267 PMID:9441900 PMID:9706149 PMID:9755104 PMID:10673743 PMID:11226294 PMID:26124276 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein] CTD PMID:11226294 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977 PMID:32493877 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]] CTD PMID:21256830 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Dithiothreitol results in decreased expression of CCND1 mRNA CTD PMID:17332266 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Dithiothreitol results in increased expression of CCNG2 mRNA CTD PMID:17332266 NCBI chr 5:93,267,573...93,276,231
Ensembl chr 5:93,267,257...93,276,231 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] CTD PMID:16280210 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 increases activity ISO Dithiothreitol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO
EXP		 Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]		 CTD PMID:17332266 PMID:27226639 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions ISO Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein CTD PMID:12486162 NCBI chr 3:58,525,821...58,557,501
Ensembl chr 3:58,525,821...58,557,501 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein		 CTD PMID:12486162 PMID:25321315 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation
multiple interactions		 EXP Dithiothreitol results in increased phosphorylation of EIF2S1 protein
EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:30385349 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010 		JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions
increases expression		 ISO Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein		 CTD PMID:12486162 PMID:25321315 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein] CTD PMID:22403704 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614 		JBrowse link
G F3 coagulation factor III increases activity ISO Dithiothreitol results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048 		JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions		 ISO
EXP		 Dithiothreitol results in increased expression of FGF21 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]		 CTD PMID:27226639 NCBI chr 7:45,613,890...45,615,490
Ensembl chr 7:45,613,886...45,615,490 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Dithiothreitol results in increased expression of GADD45A mRNA CTD PMID:17332266 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] CTD PMID:14695184 PMID:17658243 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]		 CTD PMID:24489685 PMID:26111761 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862 PMID:26859423 NCBI chr 8:105,518,746...105,523,988
Ensembl chr 8:105,518,755...105,523,988 		JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein CTD PMID:15710169 PMID:17332266 PMID:17416481 PMID:21692457 PMID:25321315 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]		 CTD PMID:17067557 PMID:20584749 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] CTD PMID:14762100 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106 		JBrowse link
G Il5ra interleukin 5 receptor, alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr 6:106,710,375...106,749,037
Ensembl chr 6:106,710,357...106,749,037 		JBrowse link
G Inhbe inhibin beta-E increases expression ISO Dithiothreitol results in increased expression of INHBE mRNA CTD PMID:22935518 NCBI chr10:127,349,402...127,351,848
Ensembl chr10:127,348,857...127,354,411 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222 		JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24853401 NCBI chr10:127,225,695...127,266,348
Ensembl chr10:127,225,696...127,263,348 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11035063 PMID:23370007 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204 PMID:16386761 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755 		JBrowse link
G Msrb2 methionine sulfoxide reductase B2 increases reduction ISO Dithiothreitol results in increased reduction of MSRB2 protein CTD PMID:16735467 NCBI chr 2:19,371,436...19,394,976
Ensembl chr 2:19,371,440...19,394,976 		JBrowse link
G Msrb3 methionine sulfoxide reductase B3 increases reduction ISO Dithiothreitol results in increased reduction of MSRB3 protein CTD PMID:16735467 NCBI chr10:120,781,100...120,899,011
Ensembl chr10:120,781,096...120,899,101 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327 		JBrowse link
G Nat1 N-acetyl transferase 1 multiple interactions
increases activity		 ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]
Dithiothreitol results in increased activity of NAT1 protein		 CTD PMID:22835378 NCBI chr 8:67,490,968...67,492,531
Ensembl chr 8:67,480,921...67,492,104 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein] CTD PMID:24489685 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP
ISO		 [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]		 CTD PMID:9281604 PMID:14762100 PMID:16219905 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO		 Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]		 CTD PMID:17067557 PMID:19509257 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP		 Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]		 CTD PMID:7532384 PMID:9706149 PMID:9755104 PMID:15907790 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein] CTD PMID:24489685 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]		 CTD PMID:2226332 PMID:2298732 PMID:15250541 PMID:16857225 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421 		JBrowse link
G Nrgn neurogranin multiple interactions ISO Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein] CTD PMID:21241739 NCBI chr 9:37,544,493...37,552,745
Ensembl chr 9:37,544,492...37,552,904 		JBrowse link
G Nudt9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]] CTD PMID:16860484 NCBI chr 5:104,045,538...104,065,378
Ensembl chr 5:104,046,306...104,065,379 		JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr11:6,291,597...6,359,094
Ensembl chr11:6,291,633...6,356,642 		JBrowse link
G P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr 5:110,339,812...110,343,320
Ensembl chr 5:110,339,812...110,343,212 		JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 increases activity ISO Dithiothreitol results in increased activity of PAPSS1 protein CTD PMID:15065880 NCBI chr 3:131,564,764...131,643,671
Ensembl chr 3:131,564,768...131,643,671 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP
ISO		 Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]		 CTD PMID:11035063 PMID:18022205 PMID:20438634 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression ISO Dithiothreitol results in increased expression of PDCD6IP protein CTD PMID:21692457 NCBI chr 9:113,651,744...113,708,279
Ensembl chr 9:113,651,744...113,708,259 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Dithiothreitol results in increased expression of PLOD3 protein CTD PMID:21692457 NCBI chr 5:136,987,019...136,996,646
Ensembl chr 5:136,987,019...136,996,648 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Dithiothreitol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]] CTD PMID:20584749 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]		 CTD PMID:16781456 PMID:32493877 NCBI chr 2:167,930,750...167,979,385
Ensembl chr 2:167,932,057...167,979,385 		JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Dithiothreitol results in increased expression of RCN2 protein CTD PMID:21692457 NCBI chr 9:56,041,845...56,059,083
Ensembl chr 9:56,041,845...56,061,882 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases activity		 EXP
ISO		 [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol results in increased activity of RELA protein
Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]		 CTD PMID:7491977 PMID:9281604 PMID:16219905 PMID:20351055 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G S100a2 S100 calcium binding protein A2 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Dithiothreitol inhibits the reaction [S100A2 protein binds to S100A2 protein] CTD PMID:21924240 NCBI chr 3:90,590,247...90,591,508
Ensembl chr 3:90,560,363...90,591,531 		JBrowse link
G S100a4 S100 calcium binding protein A4 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045 		JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462 		JBrowse link
G Sod1 superoxide dismutase 1, soluble affects folding
multiple interactions		 ISO
EXP		 Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]		 CTD PMID:22867017 PMID:26694608 PMID:26699812 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases expression		 ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions EXP Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] CTD PMID:26699812 NCBI chr10:127,642,955...127,660,987
Ensembl chr10:127,642,986...127,660,957 		JBrowse link
G Thy1 thymus cell antigen 1, theta multiple interactions EXP Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] CTD PMID:11035063 NCBI chr 9:44,043,384...44,048,579
Ensembl chr 9:44,043,384...44,048,579 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]		 CTD PMID:7476933 PMID:7532384 PMID:9281604 PMID:9388267 PMID:16219905 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein] CTD PMID:17555331 PMID:25446071 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions
increases activity		 ISO Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein		 CTD PMID:21984481 NCBI chr  X:144,377,327...144,688,180
Ensembl chr  X:144,381,671...144,688,180 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein] CTD PMID:19527742 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21552
    chemical entity 21550
      molecular entity 21534
        polyatomic entity 21410
          heteroatomic molecular entity 21336
            hydroxides 20130
              organic hydroxy compound 19164
                polyol 7904
                  diol 2701
                    butanediols 145
                      (2S)-2-amino-4-(methylsulfanyl)-1-(1,3-thiazol-2-yl)butane-1,1-diol 0
                      1,4-dimercaptobutane-2,3-diol + 90
                      butanediol + 67
                      dihydrocubebin 0
                      secoisolariciresinol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 21552
    subatomic particle 21537
      composite particle 21537
        hadron 21537
          baryon 21537
            nucleon 21537
              atomic nucleus 21537
                atom 21537
                  main group element atom 21442
                    p-block element atom 21442
                      p-block molecular entity 21441
                        chalcogen molecular entity 20515
                          oxygen molecular entity 20492
                            hydroxides 20130
                              organic hydroxy compound 19164
                                polyol 7904
                                  diol 2701
                                    butanediols 145
                                      (2S)-2-amino-4-(methylsulfanyl)-1-(1,3-thiazol-2-yl)butane-1,1-diol 0
                                      1,4-dimercaptobutane-2,3-diol + 90
                                      butanediol + 67
                                      dihydrocubebin 0
                                      secoisolariciresinol + 1
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