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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butanediols
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Accession:CHEBI:22944 term browser browse the term
Definition:A diol that is a butanediol or a derivative of a butanediol.


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(-)-secoisolariciresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO secoisolariciresinol results in increased activity of NR1I2 protein CTD PMID:15885729 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
increases activity
ISO
EXP
Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]
CTD PMID:2061546, PMID:20472051, PMID:21360559, PMID:21910133, PMID:22180340, PMID:23933410 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor multiple interactions EXP Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]] CTD PMID:6323860 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
increases reduction
EXP
ISO
Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]
CTD PMID:15025511, PMID:25349987 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Dithiothreitol results in increased expression of ATF3 mRNA CTD PMID:17332266 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Dithiothreitol results in increased expression of ATF4 mRNA CTD PMID:27226639 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:18022205 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calu calumenin increases expression ISO Dithiothreitol results in increased expression of CALU protein CTD PMID:21692457 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
CTD PMID:9388267, PMID:9441900, PMID:9706149, PMID:9755104, PMID:10673743, PMID:11226294, PMID:26124276 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein] CTD PMID:11226294 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977, PMID:32493877 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]] CTD PMID:21256830 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Dithiothreitol results in decreased expression of CCND1 mRNA CTD PMID:17332266 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Dithiothreitol results in increased expression of CCNG2 mRNA CTD PMID:17332266 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] CTD PMID:16280210 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Dithiothreitol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]
CTD PMID:17332266, PMID:27226639 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein CTD PMID:12486162 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein
CTD PMID:12486162, PMID:25321315 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein] CTD PMID:30385349 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein
CTD PMID:12486162, PMID:25321315 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein] CTD PMID:22403704 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor increases activity ISO Dithiothreitol results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of FGF21 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]
CTD PMID:27226639 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Dithiothreitol results in increased expression of GADD45A mRNA CTD PMID:17332266 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] CTD PMID:14695184, PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]
CTD PMID:24489685, PMID:26111761 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862, PMID:26859423 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO
EXP
Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein CTD PMID:15710169, PMID:17332266, PMID:17416481, PMID:21692457, PMID:25321315 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]
CTD PMID:17067557, PMID:20584749 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] CTD PMID:14762100 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Dithiothreitol results in increased expression of INHBE mRNA CTD PMID:22935518 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24853401 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]
CTD PMID:11035063, PMID:23370007 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204, PMID:16386761 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Msrb2 methionine sulfoxide reductase B2 increases reduction ISO Dithiothreitol results in increased reduction of MSRB2 protein CTD PMID:16735467 NCBI chr17:86,066,841...86,148,131
Ensembl chr17:86,066,833...86,148,130
JBrowse link
G Msrb3 methionine sulfoxide reductase B3 increases reduction ISO Dithiothreitol results in increased reduction of MSRB3 protein CTD PMID:16735467 NCBI chr 7:62,850,506...62,972,487
Ensembl chr 7:62,850,515...62,972,084
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Nat1 N-acetyltransferase 1 increases activity
multiple interactions
ISO Dithiothreitol results in increased activity of NAT1 protein
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]
CTD PMID:22835378 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein] CTD PMID:24489685 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
CTD PMID:9281604, PMID:14762100, PMID:16219905 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]
CTD PMID:17067557, PMID:19509257 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
CTD PMID:7532384, PMID:9706149, PMID:9755104, PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein] CTD PMID:24489685 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
CTD PMID:2226332, PMID:2298732, PMID:15250541, PMID:16857225 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrgn neurogranin multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein] CTD PMID:21241739 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Nudt9 nudix hydrolase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]] CTD PMID:16860484 NCBI chr14:7,036,809...7,054,739
Ensembl chr14:7,036,820...7,054,548
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 increases activity ISO Dithiothreitol results in increased activity of PAPSS1 protein CTD PMID:15065880 NCBI chr 2:236,605,695...236,680,772
Ensembl chr 2:236,605,695...236,680,772
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]
CTD PMID:11035063, PMID:18022205, PMID:20438634 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression ISO Dithiothreitol results in increased expression of PDCD6IP protein CTD PMID:21692457 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Dithiothreitol results in increased expression of PLOD3 protein CTD PMID:21692457 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Dithiothreitol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]] CTD PMID:20584749 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP
ISO
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]
CTD PMID:16781456, PMID:32493877 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Dithiothreitol results in increased expression of RCN2 protein CTD PMID:21692457 NCBI chr 8:60,709,851...60,726,938
Ensembl chr 8:60,709,851...60,726,936
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
Dithiothreitol results in increased activity of RELA protein
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
CTD PMID:7491977, PMID:9281604, PMID:16219905, PMID:20351055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Sod1 superoxide dismutase 1 affects folding
multiple interactions
ISO Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]
CTD PMID:22867017, PMID:26694608, PMID:26699812 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] CTD PMID:26699812 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] CTD PMID:11035063 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
CTD PMID:7476933, PMID:7532384, PMID:9281604, PMID:9388267, PMID:16219905 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein] CTD PMID:17555331, PMID:25446071 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein
CTD PMID:21984481 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein] CTD PMID:19527742 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
busulfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 decreases response to substance ISO ADRB2 protein results in decreased susceptibility to Busulfan CTD PMID:7202579 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of ANP32B protein CTD PMID:20933509 NCBI chr 5:62,070,709...62,094,633
Ensembl chr 5:62,071,346...62,094,633
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Busulfan CTD PMID:19470598 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor multiple interactions ISO Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions
affects response to substance
ISO ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein]
ARHGDIA mRNA affects the susceptibility to Busulfan
CTD PMID:17264767 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein CTD PMID:20933509 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Busulfan results in decreased expression of BMP4 mRNA CTD PMID:15786497 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP3 protein; [decitabine co-treated with Busulfan] results in increased activity of CASP3 protein; ARHGDIA mRNA affects the reaction [Busulfan results in increased activity of CASP3 protein] CTD PMID:17264767, PMID:18339423, PMID:19732952, PMID:20933509 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO Busulfan results in increased activity of CASP8 protein
[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]
CTD PMID:18339423, PMID:19732952 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP9 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased activity of CASP9 protein] CTD PMID:19732952, PMID:20933509 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein CTD PMID:20933509 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Busulfan results in decreased expression of CDK2 mRNA CTD PMID:15388331 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Busulfan results in decreased expression of CDK4 mRNA CTD PMID:15388331 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Busulfan results in increased expression of CDKN1A protein
[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of CDKN1A protein
CTD PMID:16882877, PMID:20933509 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Busulfan results in increased expression of CDKN2A mRNA CTD PMID:14500376 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein CTD PMID:20933509 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO Busulfan affects the expression of COL4A1 mRNA CTD PMID:15941629 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Faslg Fas ligand decreases expression ISO Busulfan results in decreased expression of FASL mRNA CTD PMID:15388331 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression EXP Busulfan results in decreased expression of FGF8 mRNA CTD PMID:15786497 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Gdnf glial cell derived neurotrophic factor affects expression
increases expression
ISO Busulfan affects the expression of GDNF mRNA
Busulfan results in increased expression of GDNF mRNA
CTD PMID:20684317, PMID:22082982, PMID:26524245 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression
ISO Busulfan results in decreased expression of and results in decreased activity of GPX4 protein; Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] CTD PMID:32416107 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects response to substance
affects metabolic processing
affects abundance
decreases response to substance
ISO GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]
GSTA1 polymorphism affects the susceptibility to Busulfan
GSTA1 gene polymorphism affects the metabolism of Busulfan; GSTA1 protein affects the metabolism of Busulfan
GSTA1 gene polymorphism affects the abundance of Busulfan
GSTA1 protein results in decreased susceptibility to Busulfan
CTD PMID:8886613, PMID:10437668, PMID:10570028, PMID:12429583, PMID:20672371, PMID:21135089, PMID:21215809, PMID:21441958 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing
affects abundance
affects response to substance
multiple interactions
ISO GSTM1 protein affects the metabolism of Busulfan
GSTM1 gene polymorphism affects the abundance of Busulfan
GSTM1 gene polymorphism affects the susceptibility to Busulfan
[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan; [GSTM1 protein co-treated with CYP2C9 protein] results in increased susceptibility to [Busulfan co-treated with Cyclophosphamide]
CTD PMID:8886613, PMID:15142875, PMID:19584821, PMID:20672371, PMID:21215809, PMID:28744217 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
affects abundance
ISO GSTP1 protein affects the metabolism of Busulfan
GSTP1 gene polymorphism affects the abundance of Busulfan
CTD PMID:8886613, PMID:20672371 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan CTD PMID:21215809 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO Busulfan results in increased phosphorylation of H2AX protein
[Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein
CTD PMID:18339423, PMID:20933509 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Inhba inhibin subunit beta A multiple interactions
increases expression
ISO bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA mRNA]; bisindolylmaleimide I inhibits the reaction [Busulfan results in increased expression of INHBA protein]
Busulfan results in increased expression of INHBA mRNA; Busulfan results in increased expression of INHBA protein
CTD PMID:12966370, PMID:22286157 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO Busulfan results in decreased expression of KIT mRNA CTD PMID:15388331 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO Busulfan affects the expression of LAMA1 mRNA CTD PMID:15941629 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO Busulfan affects the expression of LAMA4 mRNA CTD PMID:15941629 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Busulfan results in increased activity of MAPK1 protein CTD PMID:16882877 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Busulfan results in increased activity of MAPK3 protein CTD PMID:16882877 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases response to substance ISO MGST2 protein results in decreased susceptibility to Busulfan CTD PMID:15779864 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of MYC protein CTD PMID:20933509 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nanos2 nanos C2HC-type zinc finger 2 decreases expression ISO Busulfan results in decreased expression of NANOS2 mRNA; Busulfan results in decreased expression of NANOS2 protein CTD PMID:26524245 NCBI chr 1:79,894,450...79,895,910
Ensembl chr 1:79,894,450...79,895,910
JBrowse link
G Nanos3 nanos C2HC-type zinc finger 3 decreases expression ISO Busulfan results in decreased expression of NANOS3 mRNA CTD PMID:26524245 NCBI chr19:25,284,907...25,288,680
Ensembl chr19:25,284,909...25,288,335
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
ISO Busulfan results in decreased expression of NFE2L2 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of NFE2L2 protein]
CTD PMID:32416107 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO NPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin] CTD PMID:20172040 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; [decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]
Busulfan results in increased cleavage of PARP1 protein
CTD PMID:18339423, PMID:19732952, PMID:20933509 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Phb prohibitin affects expression ISO Busulfan affects the expression of PHB mRNA CTD PMID:15388331 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Busulfan results in increased expression of PTGS2 mRNA
ferrostatin-1 inhibits the reaction [Busulfan results in increased expression of PTGS2 mRNA]
CTD PMID:12966370, PMID:32416107 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Busulfan results in decreased expression of RAD51 mRNA CTD PMID:15388331 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Busulfan results in decreased phosphorylation of RB1 protein CTD PMID:15388331 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 increases expression ISO Busulfan results in increased expression of SAT2 mRNA; Busulfan results in increased expression of SAT2 protein CTD PMID:28578006 NCBI chr10:56,227,703...56,229,796
Ensembl chr10:56,227,692...56,229,850
JBrowse link
G Serpinc1 serpin family C member 1 affects expression ISO Busulfan affects the expression of SERPINC1 protein CTD PMID:15580502 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions
ISO Busulfan results in increased expression of SERPINE1 mRNA; Busulfan results in increased expression of SERPINE1 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of SERPINE1 mRNA]
CTD PMID:22286157 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions
ISO Busulfan results in decreased expression of SLC40A1 protein
Deferoxamine inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]; sulforafan inhibits the reaction [Busulfan results in decreased expression of SLC40A1 protein]
CTD PMID:32416107 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Smc1a structural maintenance of chromosomes 1A multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein CTD PMID:20933509 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC3 protein CTD PMID:20933509 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression ISO Busulfan results in decreased expression of STRA8 mRNA CTD PMID:15388331 NCBI chr 4:62,447,724...62,474,802
Ensembl chr 4:62,457,694...62,473,360
JBrowse link
G Tf transferrin multiple interactions
increases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Busulfan results in increased expression of TF mRNA]
Busulfan results in increased expression of TF mRNA; Busulfan results in increased expression of TF protein
CTD PMID:12966370, PMID:22286157 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Busulfan results in decreased expression of TFPI mRNA CTD PMID:22286157 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions
ISO Busulfan results in decreased expression of TFRC protein
Deferoxamine promotes the reaction [Busulfan results in decreased expression of TFRC protein]
CTD PMID:32416107 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Busulfan results in increased expression of TGFB1 mRNA CTD PMID:22286157 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Busulfan results in increased expression of THBS1 mRNA CTD PMID:22286157 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Busulfan results in increased expression of TNF mRNA CTD PMID:22286157 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Busulfan affects the phosphorylation of and affects the activity of TP53 protein CTD PMID:16882877 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP Busulfan results in decreased activity of TXNRD1 protein CTD PMID:16085187 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein CTD PMID:20933509 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 increases expression ISO Busulfan results in increased expression of ZBTB16 mRNA CTD PMID:26524245 NCBI chr 8:52,980,226...53,146,765
Ensembl chr 8:52,985,313...53,146,953
JBrowse link
butane-1,3-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
increases expression
EXP 1,3-butylene glycol results in increased activity of CYP2E1 protein
1,3-butylene glycol results in increased expression of CYP2E1 protein
CTD PMID:2919394 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
butane-2,3-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol CTD PMID:23295224 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO [AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol CTD PMID:23295224 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing ISO ALDH2 protein results in increased metabolism of 2,3-butylene glycol CTD PMID:10064379 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
dithioerythritol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc1a5 solute carrier family 1 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein] CTD PMID:23010140 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein] CTD PMID:25490951 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]] CTD PMID:19041296, PMID:22900493 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP
ISO
Dithioerythritol inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]
Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein]
CTD PMID:23402788, PMID:25849418 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:12614848 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
increases activity
ISO
EXP
Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]
CTD PMID:2061546, PMID:20472051, PMID:21360559, PMID:21910133, PMID:22180340, PMID:23933410 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] CTD PMID:23370007 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor multiple interactions EXP Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]] CTD PMID:6323860 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
increases reduction
EXP
ISO
Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]
CTD PMID:15025511, PMID:25349987 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Dithiothreitol results in increased expression of ATF3 mRNA CTD PMID:17332266 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Dithiothreitol results in increased expression of ATF4 mRNA CTD PMID:27226639 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:18022205 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calu calumenin increases expression ISO Dithiothreitol results in increased expression of CALU protein CTD PMID:21692457 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
CTD PMID:9388267, PMID:9441900, PMID:9706149, PMID:9755104, PMID:10673743, PMID:11226294, PMID:26124276 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] CTD PMID:11226294 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein] CTD PMID:11226294 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide] CTD PMID:7491977, PMID:32493877 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]] CTD PMID:21256830 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Dithiothreitol results in decreased expression of CCND1 mRNA CTD PMID:17332266 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Dithiothreitol results in increased expression of CCNG2 mRNA CTD PMID:17332266 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] CTD PMID:16280210 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Dithiothreitol results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]
CTD PMID:17332266, PMID:27226639 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein CTD PMID:12486162 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein
CTD PMID:12486162, PMID:25321315 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein] CTD PMID:30385349 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
EXP
ISO
Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein
CTD PMID:12486162, PMID:25321315 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein] CTD PMID:22403704 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor increases activity ISO Dithiothreitol results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression
multiple interactions
ISO Dithiothreitol results in increased expression of FGF21 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]
CTD PMID:27226639 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Dithiothreitol results in increased expression of GADD45A mRNA CTD PMID:17332266 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] CTD PMID:14695184, PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]
CTD PMID:24489685, PMID:26111761 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862, PMID:26859423 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO
EXP
Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein CTD PMID:15710169, PMID:17332266, PMID:17416481, PMID:21692457, PMID:25321315 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]
CTD PMID:17067557, PMID:20584749 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] CTD PMID:14762100 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] CTD PMID:7957178 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Dithiothreitol results in increased expression of INHBE mRNA CTD PMID:22935518 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24853401 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
CTD PMID:11035063, PMID:23370007 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] CTD PMID:10644709 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204, PMID:16386761 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Msrb2 methionine sulfoxide reductase B2 increases reduction ISO Dithiothreitol results in increased reduction of MSRB2 protein CTD PMID:16735467 NCBI chr17:86,066,841...86,148,131
Ensembl chr17:86,066,833...86,148,130
JBrowse link
G Msrb3 methionine sulfoxide reductase B3 increases reduction ISO Dithiothreitol results in increased reduction of MSRB3 protein CTD PMID:16735467 NCBI chr 7:62,850,506...62,972,487
Ensembl chr 7:62,850,515...62,972,084
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]
Dithiothreitol results in increased activity of NAT1 protein
CTD PMID:22835378 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein] CTD PMID:24489685 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]
CTD PMID:9281604, PMID:14762100, PMID:16219905 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]
CTD PMID:17067557, PMID:19509257 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
CTD PMID:7532384, PMID:9706149, PMID:9755104, PMID:15907790 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein] CTD PMID:24489685 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO
EXP
Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
CTD PMID:2226332, PMID:2298732, PMID:15250541, PMID:16857225 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrgn neurogranin multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein] CTD PMID:21241739 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Nudt9 nudix hydrolase 9 multiple interactions ISO Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]] CTD PMID:16860484 NCBI chr14:7,036,809...7,054,739
Ensembl chr14:7,036,820...7,054,548
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 increases activity ISO Dithiothreitol results in increased activity of PAPSS1 protein CTD PMID:15065880 NCBI chr 2:236,605,695...236,680,772
Ensembl chr 2:236,605,695...236,680,772
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]
CTD PMID:11035063, PMID:18022205, PMID:20438634 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression ISO Dithiothreitol results in increased expression of PDCD6IP protein CTD PMID:21692457 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Dithiothreitol results in increased expression of PLOD3 protein CTD PMID:21692457 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Dithiothreitol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]] CTD PMID:20584749 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP
ISO
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]
CTD PMID:16781456, PMID:32493877 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Dithiothreitol results in increased expression of RCN2 protein CTD PMID:21692457 NCBI chr 8:60,709,851...60,726,938
Ensembl chr 8:60,709,851...60,726,936
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol results in increased activity of RELA protein
Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
CTD PMID:7491977, PMID:9281604, PMID:16219905, PMID:20351055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Sod1 superoxide dismutase 1 affects folding
multiple interactions
ISO Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]
CTD PMID:22867017, PMID:26694608, PMID:26699812 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] CTD PMID:7476933 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] CTD PMID:26699812 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] CTD PMID:11035063 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] CTD PMID:19627980 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
CTD PMID:7476933, PMID:7532384, PMID:9281604, PMID:9388267, PMID:16219905 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:29272108 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein] CTD PMID:17555331, PMID:25446071 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions
increases activity
ISO Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein
CTD PMID:21984481 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] CTD PMID:18922898 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein] CTD PMID:19527742 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          heteroatomic molecular entity 19620
            hydroxides 19066
              organic hydroxy compound 18630
                polyol 7802
                  diol 2718
                    butanediols 143
                      (2S)-2-amino-4-(methylsulfanyl)-1-(1,3-thiazol-2-yl)butane-1,1-diol 0
                      1,4-dimercaptobutane-2,3-diol + 89
                      butanediol + 66
                      dihydrocubebin 0
                      secoisolariciresinol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      p-block molecular entity 19670
                        chalcogen molecular entity 19360
                          oxygen molecular entity 19321
                            hydroxides 19066
                              organic hydroxy compound 18630
                                polyol 7802
                                  diol 2718
                                    butanediols 143
                                      (2S)-2-amino-4-(methylsulfanyl)-1-(1,3-thiazol-2-yl)butane-1,1-diol 0
                                      1,4-dimercaptobutane-2,3-diol + 89
                                      butanediol + 66
                                      dihydrocubebin 0
                                      secoisolariciresinol + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.