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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromoalkane
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Accession:CHEBI:22929 term browser browse the term
Definition:Any haloalkane that consists of an alkane substituted by at least one bromine atom.
Synonyms:related_synonym: alkyl bromide;   alkyl bromides;   bromoalkanes



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1,2-dibromoethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO Ethylene Dibromide results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Ethylene Dibromide results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Ethylene Dibromide results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
ISO CYP2E1 protein results in increased metabolism of Ethylene Dibromide
CYP2E1 protein results in increased oxidation of Ethylene Dibromide
CTD PMID:1664256 PMID:10841534 PMID:18350910 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Ethylene Dibromide results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Ethylene Dibromide results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression ISO Ethylene Dibromide results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr14:1,009,863...1,022,620
Ensembl chr14:1,009,786...1,021,928
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity
multiple interactions
ISO Ethylene Dibromide results in increased activity of GGT1 protein
Phentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]; Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]
CTD PMID:12628311 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions
increases activity
affects response to substance
increases glutathionylation
ISO
EXP
GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of Ethylene Dibromide]; GSTT1 protein affects the metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein affects the susceptibility to Ethylene Dibromide
CTD PMID:8565128 PMID:10413528 PMID:12505322 PMID:12902151 PMID:19664997 More... NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 decreases expression ISO Ethylene Dibromide results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
JBrowse link
G Krt10 keratin 10 decreases expression ISO Ethylene Dibromide results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ethylene Dibromide results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Ethylene Dibromide results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
increases response to substance
affects binding
ISO Ethylene Dibromide binds to and results in decreased activity of MGMT protein; MGMT protein affects the metabolism of and results in increased activity of Ethylene Dibromide; MGMT protein results in increased activity of and results in increased susceptibility to Ethylene Dibromide
MGMT protein results in increased susceptibility to Ethylene Dibromide
Ethylene Dibromide binds to MGMT protein
CTD PMID:10894884 PMID:12151404 PMID:14645247 PMID:17226938 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Ethylene Dibromide results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Ethylene Dibromide results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity EXP Ethylene Dibromide results in increased activity of ODC1 protein CTD PMID:3801022 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Pard3 par-3 family cell polarity regulator increases expression ISO Ethylene Dibromide results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778
JBrowse link
G Pld3 phospholipase D family, member 3 increases expression ISO Ethylene Dibromide results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr 1:82,821,863...82,844,280
Ensembl chr 1:82,821,875...82,844,072
JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Ethylene Dibromide results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression ISO Ethylene Dibromide results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO Ethylene Dibromide results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G St7l suppression of tumorigenicity 7-like decreases expression ISO Ethylene Dibromide results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 2:192,364,594...192,434,414
Ensembl chr 2:192,364,594...192,487,190
JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Ethylene Dibromide results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Ethylene dibromide increases expression of Tnf mRNA in liver RGD PMID:7943184 RGD:14995476 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Ethylene Dibromide results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO Ethylene Dibromide results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Ethylene Dibromide results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
1-bromopropane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase decreases expression EXP 1-bromopropane results in decreased expression of ABAT protein CTD PMID:21925529 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression EXP 1-bromopropane results in increased expression of ANP32A protein CTD PMID:21925529 Ensembl chr 8:62,827,456...62,865,443 JBrowse link
G Arg1 arginase 1 increases expression
multiple interactions
EXP 1-bromopropane results in increased expression of ARG1 protein
allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of ARG1 protein]
CTD PMID:30247689 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d decreases expression EXP 1-bromopropane results in decreased expression of ATP5H protein CTD PMID:21925529 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP
ISO
1-bromopropane results in decreased expression of BCL2L1 mRNA CTD PMID:16815550 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
ISO
EXP
1-bromopropane inhibits the reaction [Bucladesine results in increased expression of BDNF mRNA]; 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF mRNA]; 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF protein]
1-bromopropane results in decreased expression of BDNF mRNA
CTD PMID:19189864 PMID:23266320 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 increases cleavage EXP 1-bromopropane results in increased cleavage of CASP3 protein CTD PMID:30247689 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression EXP 1-bromopropane results in decreased expression of CAT mRNA CTD PMID:27452781 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions
increases expression
ISO ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CCN5 mRNA] CTD PMID:23384675 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Ckb creatine kinase B decreases expression EXP 1-bromopropane results in decreased expression of CKB protein CTD PMID:21925529 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 decreases expression EXP 1-bromopropane results in decreased expression of CKMT1 protein CTD PMID:21925529 NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1-bromopropane results in decreased phosphorylation of and results in decreased activity of CREB1 protein CTD PMID:19189864 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of CXCL12 mRNA
ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CXCL12 mRNA]
CTD PMID:23384675 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP 1-bromopropane results in increased expression of CYBB mRNA; 1-bromopropane results in increased expression of CYBB protein CTD PMID:27452781 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases response to substance
increases expression
multiple interactions
ISO
EXP
CYP2E1 protein results in increased susceptibility to 1-bromopropane
1-bromopropane results in increased expression of CYP2E1
allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of CYP2E1]
CTD PMID:19638432 PMID:30247689 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Drd1 dopamine receptor D1 decreases expression EXP 1-bromopropane results in decreased expression of DRD1 mRNA CTD PMID:19576243 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP 1-bromopropane results in decreased expression of DRD2 mRNA CTD PMID:19576243 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP 1-bromopropane results in decreased expression of ECH1 protein CTD PMID:21925529 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CXCL12 mRNA] CTD PMID:23384675 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 1-bromopropane results in increased expression of ESR2 protein alternative form CTD PMID:27634370 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression EXP 1-bromopropane results in decreased expression of GABRA1 mRNA CTD PMID:19576243 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression EXP 1-bromopropane results in increased expression of GABRG2 mRNA CTD PMID:19576243 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of GCLC mRNA
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA]
CTD PMID:20211940 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLM mRNA] CTD PMID:20211940 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gda guanine deaminase decreases expression EXP 1-bromopropane results in decreased expression of GDA protein CTD PMID:21925529 NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity ISO 1-bromopropane results in increased activity of GPT protein CTD PMID:17265426 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases expression EXP 1-bromopropane results in increased expression of GRIA1 mRNA CTD PMID:32715571 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
decreases activity
multiple interactions
ISO
EXP
1-bromopropane results in increased expression of GSR mRNA
1-bromopropane results in decreased activity of GSR protein
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GSR mRNA]
CTD PMID:20211940 PMID:23395825 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP 1-bromopropane results in increased expression of GSTA3 protein CTD PMID:21925529 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP 1-bromopropane results in increased expression of GSTP1 protein CTD PMID:21925529 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of HMOX1 mRNA
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of HMOX1 mRNA]
CTD PMID:20211940 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression EXP 1-bromopropane results in decreased expression of HNRNPH1 protein CTD PMID:21925529 NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP
ISO
1-bromopropane results in increased expression of HSPA5 protein CTD PMID:21925529 PMID:27421776 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP 1-bromopropane results in increased expression of HSPD1 protein CTD PMID:21925529 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression EXP 1-bromopropane results in decreased expression of HTR1A mRNA CTD PMID:19576243 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP 1-bromopropane results in decreased expression of HTR2A mRNA CTD PMID:19576243 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression EXP 1-bromopropane results in increased expression of HTR2C mRNA CTD PMID:19576243 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects expression EXP 1-bromopropane affects the expression of HTR3A mRNA CTD PMID:19576243 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
ISO 1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]
1-bromopropane results in increased expression of IL1B mRNA
1-bromopropane results in increased secretion of IL1B protein
CTD PMID:16815550 PMID:18164123 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
ISO 1-bromopropane results in increased secretion of IL6 protein
1-bromopropane results in increased expression of IL6 mRNA
CTD PMID:18164123 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 1-bromopropane results in increased phosphorylation of MAPK1 protein
MAPK1 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:18164123 PMID:22353212 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO 1-bromopropane results in increased phosphorylation of MAPK3 protein
MAPK3 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:18164123 PMID:22353212 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
decreases response to substance
ISO
EXP
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLM mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GSR mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of HMOX1 mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of NQO1 mRNA]
1-bromopropane results in decreased expression of NFE2L2 mRNA
NFE2L2 results in decreased susceptibility to 1-bromopropane
CTD PMID:20211940 PMID:27452781 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]; MAPK1 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]; MAPK3 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:16815550 PMID:18164123 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
ISO 1-bromopropane inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
1-bromopropane results in increased degradation of NFKBIA protein
CTD PMID:16815550 PMID:18164123 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of NOS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [1-bromopropane results in increased expression of NOS2 mRNA]
1-bromopropane results in increased expression of NOS2 protein
allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of NOS2 protein]
CTD PMID:18164123 PMID:30247689 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of NQO1 mRNA
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of NQO1 mRNA]
CTD PMID:20211940 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP 1-bromopropane results in decreased expression of NR3C1 mRNA CTD PMID:23266320 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Park7 Parkinsonism associated deglycase decreases expression EXP 1-bromopropane results in decreased expression of PARK7 protein CTD PMID:21925529 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP 1-bromopropane results in increased expression of PHGDH protein CTD PMID:21925529 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Pmpcb peptidase, mitochondrial processing subunit beta decreases expression EXP 1-bromopropane results in decreased expression of PMPCB protein CTD PMID:21925529 NCBI chr 4:13,297,583...13,310,363
Ensembl chr 4:13,297,559...13,310,367
JBrowse link
G Psma1 proteasome 20S subunit alpha 1 decreases expression EXP 1-bromopropane results in decreased expression of PSMA1 protein CTD PMID:21925529 NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO 1-bromopropane results in increased expression of and results in increased activity of PTGS2 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]
1-bromopropane results in increased expression of PTGS2 mRNA
CTD PMID:22353212 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP
ISO
1-bromopropane results in increased expression of RAN protein CTD PMID:21925529 PMID:27421776 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 multiple interactions
increases expression
EXP allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of RBFOX3 protein] CTD PMID:30247689 NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO
EXP
1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
1-bromopropane results in increased phosphorylation of and results in increased activity of RELA protein; allyl sulfide inhibits the reaction [1-bromopropane results in increased phosphorylation of and results in increased activity of RELA protein]
1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]; MAPK1 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]; MAPK3 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
1-bromopropane affects the localization of RELA protein
CTD PMID:16815550 PMID:18164123 PMID:30247689 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 increases expression EXP 1-bromopropane results in increased expression of SCN1A mRNA CTD PMID:32715571 NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP 1-bromopropane results in decreased expression of SOD1 mRNA CTD PMID:27452781 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP 1-bromopropane results in decreased expression of SOD2 mRNA CTD PMID:27452781 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
ISO 1-bromopropane results in increased expression of TNF mRNA
1-bromopropane results in increased secretion of TNF protein
CTD PMID:18164123 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression
decreases expression
EXP 1-bromopropane results in increased expression of TPI1 protein
1-bromopropane results in decreased expression of TPI1 protein
CTD PMID:21925529 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
bromoethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 increases expression ISO bromoethane results in increased expression of ESR1 mRNA; bromoethane results in increased expression of ESR1 protein CTD PMID:15922381 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
bromoform term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:12505655 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:12505655 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:12505655 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation ISO bromoform results in decreased methylation of MYC promoter CTD PMID:11099637 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO bromoform results in increased expression of PCNA protein CTD PMID:11099637 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
bromomethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstt1 glutathione S-transferase theta 1 increases metabolic processing ISO GSTT1 protein results in increased metabolism of methyl bromide CTD PMID:11305778 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
dibromomethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstt1 glutathione S-transferase theta 1 multiple interactions
affects metabolic processing
ISO
EXP
GSTT1 protein affects the metabolism of and results in increased activity of methylene bromide
GSTT1 protein affects the metabolism of methylene bromide
CTD PMID:8565128 PMID:11511186 PMID:14727918 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    chemical entity 20058
      molecular entity 20055
        polyatomic entity 19983
          heteroatomic molecular entity 19923
            halide 18458
              organohalogen compound 18271
                organobromine compound 5646
                  bromoalkane 88
                    1,2,3,4,5,6-hexabromocyclohexane 0
                    1,2,3-tribromopropane 0
                    1,2,5,6,9,10-hexabromocyclododecane 0
                    1,2-dibromoethane 28
                    1-bromopropane 61
                    bromoethane 1
                    bromomethanes + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            organic hydride 18616
                              organic fundamental parent 18616
                                hydrocarbon 18367
                                  halohydrocarbon 15411
                                    haloalkane 12072
                                      bromoalkane 88
                                        1,2,3,4,5,6-hexabromocyclohexane 0
                                        1,2,3-tribromopropane 0
                                        1,2,5,6,9,10-hexabromocyclododecane 0
                                        1,2-dibromoethane 28
                                        1-bromopropane 61
                                        bromoethane 1
                                        bromomethanes + 6
paths to the root