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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromoalkane
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Accession:CHEBI:22929 term browser browse the term
Definition:Any haloalkane that consists of an alkane substituted by at least one bromine atom.
Synonyms:related_synonym: alkyl bromide;   alkyl bromides;   bromoalkanes


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1,2-dibromoethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO Ethylene Dibromide results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Ethylene Dibromide results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:12,573,604...12,602,407
Ensembl chr 7:12,574,198...12,601,674
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Ethylene Dibromide results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
ISO CYP2E1 protein results in increased metabolism of Ethylene Dibromide
CYP2E1 protein results in increased oxidation of Ethylene Dibromide
CTD PMID:1664256, PMID:10841534, PMID:18350910 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Ethylene Dibromide results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Ethylene Dibromide results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression ISO Ethylene Dibromide results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr14:2,020,110...2,032,169
Ensembl chr14:2,018,500...2,032,593
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity
multiple interactions
ISO Ethylene Dibromide results in increased activity of GGT1 protein
Phentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]; Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]
CTD PMID:12628311 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions
increases activity
affects response to substance
increases glutathionylation
ISO
EXP
GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of Ethylene Dibromide]; GSTT1 protein affects the metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein affects the susceptibility to Ethylene Dibromide
CTD PMID:8565128, PMID:10413528, PMID:12505322, PMID:12902151, PMID:19664997, PMID:21781954 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 decreases expression ISO Ethylene Dibromide results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr12:25,264,052...25,370,947
Ensembl chr12:25,264,192...25,371,001
JBrowse link
G Krt10 keratin 10 decreases expression ISO Ethylene Dibromide results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ethylene Dibromide results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Ethylene Dibromide results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
increases response to substance
affects binding
ISO Ethylene Dibromide binds to and results in decreased activity of MGMT protein; MGMT protein affects the metabolism of and results in increased activity of Ethylene Dibromide; MGMT protein results in increased activity of and results in increased susceptibility to Ethylene Dibromide
MGMT protein results in increased susceptibility to Ethylene Dibromide
Ethylene Dibromide binds to MGMT protein
CTD PMID:10894884, PMID:12151404, PMID:14645247, PMID:17226938 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Ethylene Dibromide results in increased activity of NFE2L2 protein CTD PMID:30114225, PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Ethylene Dibromide results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity EXP Ethylene Dibromide results in increased activity of ODC1 protein CTD PMID:3801022 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pard3 par-3 family cell polarity regulator increases expression ISO Ethylene Dibromide results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
JBrowse link
G Pld3 phospholipase D family, member 3 increases expression ISO Ethylene Dibromide results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr 1:84,339,269...84,361,686
Ensembl chr 1:84,339,261...84,353,725
JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Ethylene Dibromide results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:66,673,060...66,783,501
Ensembl chr 3:66,673,071...66,780,075
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression ISO Ethylene Dibromide results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 4:144,537,329...144,620,606
Ensembl chr 4:144,536,729...144,620,731
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO Ethylene Dibromide results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G St7l suppression of tumorigenicity 7-like decreases expression ISO Ethylene Dibromide results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 2:207,350,651...207,421,082
Ensembl chr 2:207,350,651...207,473,857
JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Ethylene Dibromide results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:176,124,846...176,144,531
Ensembl chr 3:176,125,482...176,144,531
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Ethylene dibromide increases expression of Tnf mRNA in liver RGD PMID:7943184 RGD:14995476 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Ethylene Dibromide results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO Ethylene Dibromide results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Ethylene Dibromide results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:48,903,540...48,925,036
Ensembl chr10:48,903,540...48,925,030
JBrowse link
1-bromopropane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase decreases expression EXP 1-bromopropane results in decreased expression of ABAT protein CTD PMID:21925529 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression EXP 1-bromopropane results in increased expression of ANP32A protein CTD PMID:21925529 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
JBrowse link
G Arg1 arginase 1 increases expression
multiple interactions
EXP 1-bromopropane results in increased expression of ARG1 protein
allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of ARG1 protein]
CTD PMID:30247689 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d decreases expression EXP 1-bromopropane results in decreased expression of ATP5H protein CTD PMID:21925529 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP
ISO
1-bromopropane results in decreased expression of BCL2L1 mRNA CTD PMID:16815550 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
ISO
EXP
1-bromopropane inhibits the reaction [Bucladesine results in increased expression of BDNF mRNA]; 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF mRNA]; 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF protein]
1-bromopropane results in decreased expression of BDNF mRNA
CTD PMID:19189864, PMID:23266320 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 increases cleavage EXP 1-bromopropane results in increased cleavage of CASP3 protein CTD PMID:30247689 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression EXP 1-bromopropane results in decreased expression of CAT mRNA CTD PMID:27452781 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions
increases expression
ISO ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CCN5 mRNA] CTD PMID:23384675 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Ckb creatine kinase B decreases expression EXP 1-bromopropane results in decreased expression of CKB protein CTD PMID:21925529 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 decreases expression EXP 1-bromopropane results in decreased expression of CKMT1 protein CTD PMID:21925529 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1-bromopropane results in decreased phosphorylation of and results in decreased activity of CREB1 protein CTD PMID:19189864 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of CXCL12 mRNA
ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CXCL12 mRNA]
CTD PMID:23384675 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP 1-bromopropane results in increased expression of CYBB mRNA; 1-bromopropane results in increased expression of CYBB protein CTD PMID:27452781 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases response to substance
increases expression
multiple interactions
ISO
EXP
CYP2E1 protein results in increased susceptibility to 1-bromopropane
1-bromopropane results in increased expression of CYP2E1
allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of CYP2E1]
CTD PMID:19638432, PMID:30247689 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Drd1 dopamine receptor D1 decreases expression EXP 1-bromopropane results in decreased expression of DRD1 mRNA CTD PMID:19576243 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP 1-bromopropane results in decreased expression of DRD2 mRNA CTD PMID:19576243 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP 1-bromopropane results in decreased expression of ECH1 protein CTD PMID:21925529 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [1-bromopropane results in increased expression of CXCL12 mRNA] CTD PMID:23384675 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO 1-bromopropane results in increased expression of ESR2 protein alternative form CTD PMID:27634370 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression EXP 1-bromopropane results in decreased expression of GABRA1 mRNA CTD PMID:19576243 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression EXP 1-bromopropane results in increased expression of GABRG2 mRNA CTD PMID:19576243 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of GCLC mRNA
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA]
CTD PMID:20211940 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLM mRNA] CTD PMID:20211940 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gda guanine deaminase decreases expression EXP 1-bromopropane results in decreased expression of GDA protein CTD PMID:21925529 NCBI chr 1:238,982,542...239,057,663
Ensembl chr 1:238,982,392...239,057,732
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity ISO 1-bromopropane results in increased activity of GPT protein CTD PMID:17265426 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
decreases activity
multiple interactions
ISO
EXP
1-bromopropane results in increased expression of GSR mRNA
1-bromopropane results in decreased activity of GSR protein
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GSR mRNA]
CTD PMID:20211940, PMID:23395825 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP 1-bromopropane results in increased expression of GSTA3 protein CTD PMID:21925529 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP 1-bromopropane results in increased expression of GSTP1 protein CTD PMID:21925529 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of HMOX1 mRNA
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of HMOX1 mRNA]
CTD PMID:20211940 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression EXP 1-bromopropane results in decreased expression of HNRNPH1 protein CTD PMID:21925529 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP
ISO
1-bromopropane results in increased expression of HSPA5 protein CTD PMID:21925529, PMID:27421776 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP 1-bromopropane results in increased expression of HSPD1 protein CTD PMID:21925529 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression EXP 1-bromopropane results in decreased expression of HTR1A mRNA CTD PMID:19576243 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP 1-bromopropane results in decreased expression of HTR2A mRNA CTD PMID:19576243 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression EXP 1-bromopropane results in increased expression of HTR2C mRNA CTD PMID:19576243 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects expression EXP 1-bromopropane affects the expression of HTR3A mRNA CTD PMID:19576243 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
ISO 1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]
1-bromopropane results in increased expression of IL1B mRNA
1-bromopropane results in increased secretion of IL1B protein
CTD PMID:16815550, PMID:18164123 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
ISO 1-bromopropane results in increased secretion of IL6 protein
1-bromopropane results in increased expression of IL6 mRNA
CTD PMID:18164123 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 1-bromopropane results in increased phosphorylation of MAPK1 protein
MAPK1 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:18164123, PMID:22353212 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO 1-bromopropane results in increased phosphorylation of MAPK3 protein
MAPK3 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:18164123, PMID:22353212 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
decreases response to substance
ISO
EXP
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLM mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GSR mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of HMOX1 mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of NQO1 mRNA]
1-bromopropane results in decreased expression of NFE2L2 mRNA
NFE2L2 results in decreased susceptibility to 1-bromopropane
CTD PMID:20211940, PMID:27452781 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]; MAPK1 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]; MAPK3 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:16815550, PMID:18164123 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
ISO 1-bromopropane inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
1-bromopropane results in increased degradation of NFKBIA protein
CTD PMID:16815550, PMID:18164123 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of NOS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [1-bromopropane results in increased expression of NOS2 mRNA]
1-bromopropane results in increased expression of NOS2 protein
allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of NOS2 protein]
CTD PMID:18164123, PMID:30247689 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO 1-bromopropane results in increased expression of NQO1 mRNA
NFE2L2 promotes the reaction [1-bromopropane results in increased expression of NQO1 mRNA]
CTD PMID:20211940 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP 1-bromopropane results in decreased expression of NR3C1 mRNA CTD PMID:23266320 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Park7 Parkinsonism associated deglycase decreases expression EXP 1-bromopropane results in decreased expression of PARK7 protein CTD PMID:21925529 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP 1-bromopropane results in increased expression of PHGDH protein CTD PMID:21925529 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pmpcb peptidase, mitochondrial processing subunit beta decreases expression EXP 1-bromopropane results in decreased expression of PMPCB protein CTD PMID:21925529 NCBI chr 4:9,908,838...9,921,615
Ensembl chr 4:9,908,831...9,921,610
JBrowse link
G Psma1 proteasome 20S subunit alpha 1 decreases expression EXP 1-bromopropane results in decreased expression of PSMA1 protein CTD PMID:21925529 NCBI chr 1:183,733,567...183,744,586
Ensembl chr 1:183,733,567...183,744,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO 1-bromopropane results in increased expression of and results in increased activity of PTGS2 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]
1-bromopropane results in increased expression of PTGS2 mRNA
CTD PMID:22353212 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP
ISO
1-bromopropane results in increased expression of RAN protein CTD PMID:21925529, PMID:27421776 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 multiple interactions
increases expression
EXP allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of RBFOX3 protein] CTD PMID:30247689 NCBI chr10:107,517,916...107,850,764
Ensembl chr10:107,516,995...107,539,658
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO
EXP
1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
1-bromopropane results in increased phosphorylation of and results in increased activity of RELA protein; allyl sulfide inhibits the reaction [1-bromopropane results in increased phosphorylation of and results in increased activity of RELA protein]
1-bromopropane inhibits the reaction [IL1B protein results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; 1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]; MAPK1 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]; MAPK3 protein affects the reaction [1-bromopropane results in increased activity of [NFKB1 protein binds to RELA protein]]
1-bromopropane affects the localization of RELA protein
CTD PMID:16815550, PMID:18164123, PMID:30247689 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP 1-bromopropane results in decreased expression of SOD1 mRNA CTD PMID:27452781 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP 1-bromopropane results in decreased expression of SOD2 mRNA CTD PMID:27452781 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
ISO 1-bromopropane results in increased expression of TNF mRNA
1-bromopropane results in increased secretion of TNF protein
CTD PMID:18164123 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression
decreases expression
EXP 1-bromopropane results in increased expression of TPI1 protein
1-bromopropane results in decreased expression of TPI1 protein
CTD PMID:21925529 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
bromoform term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:12505655 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:12505655 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:12505655 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation ISO bromoform results in decreased methylation of MYC promoter CTD PMID:11099637 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO bromoform results in increased expression of PCNA protein CTD PMID:11099637 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
bromomethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstt1 glutathione S-transferase theta 1 increases metabolic processing ISO GSTT1 protein results in increased metabolism of methyl bromide CTD PMID:11305778 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
dibromomethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstt1 glutathione S-transferase theta 1 multiple interactions
affects metabolic processing
ISO
EXP
GSTT1 protein affects the metabolism of and results in increased activity of methylene bromide
GSTT1 protein affects the metabolism of methylene bromide
CTD PMID:8565128, PMID:11511186, PMID:14727918 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        polyatomic entity 19727
          heteroatomic molecular entity 19653
            halide 18039
              organohalogen compound 17784
                organobromine compound 5407
                  bromoalkane 86
                    1,2,3,4,5,6-hexabromocyclohexane 0
                    1,2,3-tribromopropane 0
                    1,2,5,6,9,10-hexabromocyclododecane 0
                    1,2-dibromoethane 28
                    1-bromopropane 59
                    bromomethanes + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  halohydrocarbon 13956
                                    haloalkane 11674
                                      bromoalkane 86
                                        1,2,3,4,5,6-hexabromocyclohexane 0
                                        1,2,3-tribromopropane 0
                                        1,2,5,6,9,10-hexabromocyclododecane 0
                                        1,2-dibromoethane 28
                                        1-bromopropane 59
                                        bromomethanes + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.