|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] |
CTD |
PMID:17098227 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] |
CTD |
PMID:22886847 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
sapropterin inhibits the reaction [Methotrexate results in increased expression of CDKN1A protein] |
CTD |
PMID:22183962 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Epo |
erythropoietin |
multiple interactions increases abundance |
ISO |
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin] EPO protein results in increased abundance of sapropterin EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin] |
CTD |
PMID:25041251 PMID:25490417 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
|
|
G |
Gch1 |
GTP cyclohydrolase 1 |
decreases abundance affects abundance multiple interactions increases chemical synthesis |
ISO |
GCH1 mutant form results in decreased abundance of sapropterin GCH1 protein affects the abundance of sapropterin [GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; [resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin GCH1 protein results in increased chemical synthesis of sapropterin EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin] |
CTD |
PMID:14551046 PMID:20610621 PMID:21963838 PMID:25041251 PMID:25490417 |
|
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
|
|
G |
Nos3 |
nitric oxide synthase 3 |
increases activity multiple interactions |
ISO |
sapropterin results in increased activity of NOS3 protein sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides] [NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] |
CTD |
PMID:19011239 PMID:23753407 PMID:25490417 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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|
G |
Sct |
secretin |
increases abundance |
ISO |
SCT protein results in increased abundance of sapropterin |
CTD |
PMID:16168596 |
|
NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
|
|
G |
Snca |
synuclein alpha |
increases abundance |
ISO |
SNCA mutant form results in increased abundance of sapropterin |
CTD |
PMID:24148766 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
sapropterin inhibits the reaction [Methotrexate results in increased expression of TP53 protein] |
CTD |
PMID:22183962 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects abundance multiple interactions |
ISO |
ABCC1 protein affects the abundance of Biopterins analog ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Biopterins analog] |
CTD |
PMID:17272743 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Agt |
angiotensinogen |
multiple interactions decreases abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Biopterins analog] |
CTD |
PMID:17272743 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
|
G |
App |
amyloid beta precursor protein |
increases abundance multiple interactions |
ISO |
APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin] |
CTD |
PMID:22886847 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Epo |
erythropoietin |
multiple interactions |
ISO |
EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin] |
CTD |
PMID:25041251 PMID:25490417 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
|
|
G |
Gch1 |
GTP cyclohydrolase 1 |
increases abundance multiple interactions |
ISO |
GCH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin [GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin] |
CTD |
PMID:25490417 |
|
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
|
|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides] |
CTD |
PMID:19011239 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions affects abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Biopterins analog] ABCC1 protein affects the abundance of Biopterins analog |
CTD |
PMID:17272743 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Agt |
angiotensinogen |
multiple interactions decreases abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Biopterins analog] |
CTD |
PMID:17272743 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] |
CTD |
PMID:17098227 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] |
CTD |
PMID:22886847 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
sapropterin inhibits the reaction [Methotrexate results in increased expression of CDKN1A protein] |
CTD |
PMID:22183962 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Epo |
erythropoietin |
multiple interactions increases abundance |
ISO |
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin] EPO protein results in increased abundance of sapropterin EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin] |
CTD |
PMID:25041251 PMID:25490417 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
|
|
G |
Gch1 |
GTP cyclohydrolase 1 |
decreases abundance affects abundance multiple interactions increases chemical synthesis |
ISO |
GCH1 mutant form results in decreased abundance of sapropterin GCH1 protein affects the abundance of sapropterin [GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; [Resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin GCH1 protein results in increased chemical synthesis of sapropterin EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin] |
CTD |
PMID:14551046 PMID:20610621 PMID:21963838 PMID:25041251 PMID:25490417 |
|
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
|
|
G |
Nos3 |
nitric oxide synthase 3 |
increases activity multiple interactions |
ISO |
sapropterin results in increased activity of NOS3 protein sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides] [NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] |
CTD |
PMID:19011239 PMID:23753407 PMID:25490417 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Sct |
secretin |
increases abundance |
ISO |
SCT protein results in increased abundance of sapropterin |
CTD |
PMID:16168596 |
|
NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
|
|
G |
Snca |
synuclein alpha |
increases abundance |
ISO |
SNCA mutant form results in increased abundance of sapropterin |
CTD |
PMID:24148766 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
sapropterin inhibits the reaction [Methotrexate results in increased expression of TP53 protein] |
CTD |
PMID:22183962 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|