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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:berberine alkaloid
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Accession:CHEBI:22754 term browser browse the term
Synonyms:related_synonym: berberine alkaloids;   berberines

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berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Berberine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589 		JBrowse link
G Acan aggrecan decreases expression ISO Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA] CTD PMID:29170048 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Berberine results in decreased expression of ACTA2 protein CTD PMID:17973934 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity EXP
ISO		 Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein		 CTD PMID:23954465 PMID:30138605 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162 		JBrowse link
G Alb albumin multiple interactions EXP Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991 		JBrowse link
G Aurkc aurora kinase C increases expression ISO Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr 1:69,958,452...69,964,546
Ensembl chr 1:69,958,452...69,963,592 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 [Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Niacinamide] results in increased expression of BAX protein; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]		 CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions		 ISO Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA		 CTD PMID:26712469 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]		 CTD PMID:16505103 PMID:20656010 PMID:23954465 PMID:24751971 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA		 CTD PMID:26712469 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions		 ISO Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]		 CTD PMID:26478571 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression		 ISO
EXP		 [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA		 CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO
EXP		 Berberine results in increased cleavage of CASP9 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein		 CTD PMID:16505103 PMID:26712469 PMID:30138605 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein] CTD PMID:20828602 PMID:24751971 PMID:25600690 PMID:30138605 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] CTD PMID:16391493 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Berberine results in decreased expression of CCND1 protein CTD PMID:16505103 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Ccnt1 cyclin T1 multiple interactions EXP Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr 7:140,215,052...140,245,958
Ensembl chr 7:140,219,551...140,245,723 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO Berberine results in increased expression of CD36 mRNA
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]		 CTD PMID:28038998 PMID:29408570 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Berberine results in decreased expression of CDK4 protein CTD PMID:16505103 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 multiple interactions EXP Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Berberine results in increased expression of CDKN1A protein CTD PMID:16505103 PMID:23747414 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression		 ISO Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA		 CTD PMID:20564506 PMID:26478571 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects phosphorylation
multiple interactions
increases expression		 ISO Berberine affects the phosphorylation of CEBPB protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CEBPB mRNA		 CTD PMID:28038998 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Berberine results in increased expression of COL1A1 mRNA CTD PMID:26478571 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression ISO Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Crebbp CREB binding protein increases expression ISO Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]		 CTD PMID:26478571 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Berberine affects the localization of CYCS protein CTD PMID:16505103 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]		 CTD PMID:16046213 PMID:22342832 PMID:24583342 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA		 CTD PMID:22342832 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression		 ISO Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B9 mRNA]; Berberine promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]
Berberine results in increased expression of CYP2B9 mRNA		 CTD PMID:22342832 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions		 ISO Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]		 CTD PMID:22342832 PMID:25455889 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
multiple interactions
decreases expression		 EXP
ISO		 Berberine results in decreased activity of CYP3A4 protein
Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 mRNA]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased expression of CYP3A4 protein]; Simvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Berberine results in decreased expression of CYP3A4 mRNA; Berberine results in decreased expression of CYP3A4 protein		 CTD PMID:21524698 PMID:30086269 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786 		JBrowse link
G Dzip3 DAZ interacting zinc finger protein 3 increases expression ISO Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr11:54,404,777...54,475,361
Ensembl chr11:54,404,446...54,472,447 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
multiple interactions
increases expression		 ISO Berberine results in decreased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]		 CTD PMID:26478571 PMID:29408570 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein		 CTD PMID:20564506 PMID:20656010 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand increases expression ISO Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA] CTD PMID:30138605 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP		 Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]		 CTD PMID:24751971 PMID:25455889 PMID:30138605 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 ISO Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]		 CTD PMID:20462044 PMID:23954465 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971 PMID:25600690 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr17:44,527,990...44,528,557
Ensembl chr17:44,528,125...44,528,511 		JBrowse link
G H2ax H2A.X variant histone increases expression
decreases expression
multiple interactions		 ISO Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]		 CTD PMID:23363784 PMID:23747414 PMID:27311644 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr17:44,527,421...44,527,801
Ensembl chr17:44,527,421...44,527,801 		JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO Berberine results in decreased expression of H2BC9 mRNA CTD PMID:27311644 NCBI chr17:44,519,815...44,520,269
Ensembl chr17:44,519,860...44,520,240 		JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO Berberine results in decreased expression of H3C1 mRNA CTD PMID:27311644 NCBI chr17:43,616,206...43,616,735
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131 		JBrowse link
G H3f3a H3.3 histone A decreases expression ISO Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr13:99,091,246...99,102,828
Ensembl chr13:99,091,763...99,101,208 		JBrowse link
G H3f4 H3.4 histone decreases expression ISO Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr10:45,304,696...45,305,106 JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr 4:170,144,871...170,145,311
Ensembl chr 4:170,144,951...170,145,262 		JBrowse link
G Hat1 histone acetyltransferase 1 increases expression ISO Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 3:58,022,395...58,070,067
Ensembl chr 3:58,022,238...58,070,068 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198 		JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042 		JBrowse link
G Hdac8 histone deacetylase 8 decreases expression ISO Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:72,163,777...72,370,058
Ensembl chr  X:72,163,777...72,370,044 		JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
increases expression		 ISO Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA		 CTD PMID:27311644 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119 		JBrowse link
G Hgf hepatocyte growth factor increases expression
multiple interactions		 ISO Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]		 CTD PMID:29408570 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Hist1h2af histone cluster 1 H2A family member F decreases expression ISO Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr17:43,627,237...43,627,629
Ensembl chr17:43,627,237...43,627,629 		JBrowse link
G Hist1h2ah histone cluster 1 H2A family member H decreases expression ISO Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr17:43,632,354...43,632,851
Ensembl chr17:44,747,796...44,748,188
Ensembl chr17:44,747,796...44,748,188 		JBrowse link
G Hist1h2ak histone cluster 1, H2ak decreases expression ISO Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr17:44,840,990...44,841,382
Ensembl chr17:44,840,990...44,841,382 		JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D decreases expression ISO Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr17:44,833,924...44,834,305
Ensembl chr17:44,833,924...44,834,305 		JBrowse link
G Hist1h2bl histone cluster 1 H2B family member l decreases expression ISO Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr17:44,748,445...44,748,910
Ensembl chr17:44,748,482...44,748,862 		JBrowse link
G Hist1h2bq histone cluster 1 H2B family member Q decreases expression ISO Berberine results in decreased expression of H2BC7 mRNA CTD PMID:27311644 NCBI chr17:43,679,925...43,689,311
Ensembl chr17:43,679,925...43,689,311 		JBrowse link
G Hist1h3b histone cluster 1, H3b decreases expression ISO Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr17:44,760,023...44,764,058
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131 		JBrowse link
G Hist1h4b histone cluster 1 H4 family member B decreases expression ISO Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr17:44,522,144...44,526,587
Ensembl chr17:44,522,140...44,526,583 		JBrowse link
G Hist2h2aa3 histone cluster 2 H2A family member A3 decreases expression ISO Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 2:198,388,766...198,389,293
Ensembl chr 2:198,388,809...198,389,201
Ensembl chr 2:198,388,809...198,389,201 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E decreases expression ISO Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 2:198,360,837...198,363,399
Ensembl chr 2:198,360,998...198,361,378 		JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression ISO Berberine results in decreased expression of H4C2 mRNA CTD PMID:27311644 NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of HMOX1 protein
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]		 CTD PMID:23954465 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP
ISO		 Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]		 CTD PMID:18563319 PMID:25455889 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein		 CTD PMID:23954465 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 ISO
EXP		 Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA
Berberine results in increased expression of IL10 mRNA		 CTD PMID:21867779 PMID:30138605 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]		 CTD PMID:16391493 PMID:29170048 PMID:30138605 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 increases expression ISO Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA		 CTD PMID:21867779 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]
Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]		 CTD PMID:28916288 PMID:29170048 PMID:30138605 PMID:30240693 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itga1 integrin subunit alpha 1 increases expression ISO Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects localization
multiple interactions		 EXP Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]		 CTD PMID:18294404 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 EXP Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]		 CTD PMID:30086269 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kdm1a lysine demethylase 1A increases expression ISO Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171 		JBrowse link
G Kdm4a lysine demethylase 4A increases expression ISO Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 5:136,967,650...137,014,402
Ensembl chr 5:136,967,650...137,014,430 		JBrowse link
G Kdm5b lysine demethylase 5B increases expression ISO Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357 		JBrowse link
G Kdm6a lysine demethylase 6A increases expression ISO Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:4,805,493...4,945,788
Ensembl chr  X:4,806,277...4,945,944 		JBrowse link
G Kdm6b lysine demethylase 6B increases expression ISO Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr10:56,000,494...56,009,582
Ensembl chr10:56,001,799...56,008,885 		JBrowse link
G Kmt5a lysine methyltransferase 5A increases expression ISO Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr12:37,558,150...37,581,183
Ensembl chr12:37,559,770...37,574,750 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 ISO
EXP		 Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]		 CTD PMID:18640378 PMID:20564506 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G LOC103690190 histone H2A type 1-E decreases expression ISO Berberine results in decreased expression of H2AC6 mRNA CTD PMID:27311644 NCBI chr17:44,747,686...44,748,229
Ensembl chr17:44,747,796...44,748,188
Ensembl chr17:44,747,796...44,748,188 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 EXP
ISO		 Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]		 CTD PMID:18294404 PMID:20462044 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111 		JBrowse link
G Mir19a microRNA 19a decreases expression ISO Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr15:100,180,162...100,180,243
Ensembl chr15:100,180,162...100,180,243 		JBrowse link
G Mir92a1 microRNA 92a-1 decreases expression ISO Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr15:100,180,586...100,180,663
Ensembl chr15:100,180,586...100,180,663 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018 		JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions
decreases expression		 EXP arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]		 CTD PMID:18294404 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects localization		 EXP arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
decreases expression		 ISO [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
increases activity
multiple interactions		 ISO
EXP		 Berberine results in increased expression of NFE2L2 protein
Berberine results in increased activity of NFE2L2 protein
Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]		 CTD PMID:23523906 PMID:23954465 PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:21963898 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]		 CTD PMID:21095217 PMID:23523906 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions IEP Berberine reverses reaction [Carbon tetrachloride decreases Nqo1 mRNA in liver] RGD PMID:31432116 RGD:25823187 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:21524698 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 decreases expression ISO Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr14:82,119,210...82,196,501
Ensembl chr14:82,119,210...82,171,480 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
decreases expression		 EXP arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Omd osteomodulin increases expression ISO Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr17:15,476,100...15,484,324
Ensembl chr17:15,475,710...15,484,269
Ensembl chr17:15,475,710...15,484,269 		JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein		 CTD PMID:16505103 PMID:26712469 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:25455889 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases response to substance
increases expression
decreases expression		 ISO Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
PPARG mRNA results in increased susceptibility to Berberine
Berberine results in increased expression of PPARG mRNA
Berberine results in decreased expression of PPARG mRNA		 CTD PMID:20564506 PMID:26478571 PMID:29408570 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prg4 proteoglycan 4 decreases expression ISO Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr13:67,672,588...67,688,902
Ensembl chr13:67,672,878...67,688,477 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases activity		 EXP arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 decreases expression ISO Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr 1:100,971,132...100,980,411
Ensembl chr 1:100,971,273...100,980,340 		JBrowse link
G Prmt2 protein arginine methyltransferase 2 increases expression ISO Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr20:13,154,513...13,212,613
Ensembl chr20:13,156,241...13,212,606 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 increases expression ISO Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr15:33,156,508...33,165,893
Ensembl chr15:33,156,492...33,165,895 		JBrowse link
G Prmt6 protein arginine methyltransferase 6 increases expression ISO Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 2:213,173,403...213,180,721
Ensembl chr 2:213,173,403...213,178,632
Ensembl chr 2:213,173,403...213,178,632 		JBrowse link
G Prmt7 protein arginine methyltransferase 7 increases expression ISO Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr19:38,189,605...38,237,155
Ensembl chr19:38,189,605...38,237,308 		JBrowse link
G Prmt8 protein arginine methyltransferase 8 increases expression ISO Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr 4:160,253,409...160,334,647
Ensembl chr 4:160,253,073...160,334,910 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression		 ISO ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
Berberine results in increased expression of PTEN protein		 CTD PMID:29408570 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rbp4 retinol binding protein 4 multiple interactions EXP Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein] CTD PMID:23523906 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G RGD1562378 histone H4 variant H4-v.1 decreases expression ISO Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr 4:170,762,862...170,763,962
Ensembl chr 4:170,763,605...170,763,916 		JBrowse link
G Rln1 relaxin 1 affects binding
increases expression
multiple interactions		 EXP Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA		 CTD PMID:22363579 NCBI chr 1:247,483,298...247,486,331
Ensembl chr 1:247,483,302...247,486,202 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
increases expression		 ISO CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr12:38,843,167...38,869,180
Ensembl chr12:38,845,621...38,869,346 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 8:118,802,478...118,888,224
Ensembl chr 8:118,803,075...118,888,224 		JBrowse link
G Setd3 SET domain containing 3, actin histidine methyltransferase increases expression ISO Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr 6:132,023,128...132,090,072
Ensembl chr 6:132,023,945...132,075,875 		JBrowse link
G Setd5 SET domain containing 5 increases expression ISO Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 4:145,017,549...145,095,247
Ensembl chr 4:145,017,608...145,095,245 		JBrowse link
G Setd6 SET domain containing 6, protein lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr19:9,758,613...9,766,333
Ensembl chr19:9,762,489...9,765,484 		JBrowse link
G Setd7 SET domain containing 7, histone lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 2:140,576,188...140,618,405
Ensembl chr 2:140,576,188...140,618,405 		JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 increases expression ISO Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 2:196,495,867...196,527,412
Ensembl chr 2:196,495,867...196,527,127 		JBrowse link
G Setdb2 SET domain bifurcated histone lysine methyltransferase 2 increases expression ISO Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr15:38,699,135...39,745,035
Ensembl chr15:39,712,861...39,742,103
Ensembl chr15:39,712,861...39,742,103 		JBrowse link
G Si sucrase-isomaltase decreases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]		 CTD PMID:20229011 NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions		 ISO Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]		 CTD PMID:26712469 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
decreases expression		 ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein		 CTD PMID:26712469 PMID:27311644 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 decreases expression ISO Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Slc6a19 solute carrier family 6 member 19 multiple interactions EXP Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr 1:32,199,869...32,218,628
Ensembl chr 1:32,199,810...32,220,045 		JBrowse link
G Smyd3 SET and MYND domain containing 3 affects expression ISO Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr13:97,330,120...97,807,813 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA] CTD PMID:21095217 PMID:22775417 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP		 Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]		 CTD PMID:22775417 PMID:24751971 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
G Sp7 Sp7 transcription factor increases expression ISO Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484 		JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression ISO Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]		 CTD PMID:26478571 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 ISO Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA		 CTD PMID:20564506 PMID:26478571 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 EXP Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]		 CTD PMID:17973934 PMID:23523906 PMID:30138605 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:21963898 PMID:30240693 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO
EXP		 Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]		 CTD PMID:16391493 PMID:20656010 PMID:21095217 PMID:21867779 PMID:23523906 PMID:25600690 PMID:28533128 PMID:29170048 PMID:30240693 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
affects response to substance		 ISO TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine		 CTD PMID:23747414 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein		 CTD PMID:20656010 PMID:26712469 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620 		JBrowse link
G Tstd1 thiosulfate sulfurtransferase like domain containing 1 increases expression ISO Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr13:89,805,652...89,807,355
Ensembl chr13:89,805,962...89,807,243 		JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A decreases expression ISO Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:123,486,988...123,497,726
Ensembl chr  X:123,486,989...123,497,726 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA] CTD PMID:28533128 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576 		JBrowse link
canadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO canadine results in increased expression of CYP1A2 mRNA; canadine results in increased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO canadine results in increased expression of CYP2E1 mRNA; canadine results in increased expression of CYP2E1 protein CTD PMID:28257954 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
columbamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh5 cadherin 5 increases expression ISO columbamine results in increased expression of CDH5 mRNA CTD PMID:23124089 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO columbamine results in decreased expression of CDK6 mRNA; columbamine results in decreased expression of CDK6 protein CTD PMID:23124089 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] CTD PMID:23124089 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Ephb2 Eph receptor B2 decreases expression ISO columbamine results in decreased expression of EPHB2 mRNA CTD PMID:23124089 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456 		JBrowse link
G Maged1 MAGE family member D1 decreases expression ISO columbamine results in decreased expression of MAGED1 mRNA CTD PMID:23124089 NCBI chr  X:63,803,194...63,809,715
Ensembl chr  X:63,803,189...63,809,861 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO columbamine results in decreased expression of MMP2 mRNA CTD PMID:23124089 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Sox17 SRY-box transcription factor 17 decreases expression ISO columbamine results in decreased expression of SOX17 mRNA CTD PMID:23124089 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] CTD PMID:23124089 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
palmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases export
increases expression		 ISO
EXP		 palmatine inhibits the reaction [ABCB1A protein results in increased export of Fluorescent Dyes]
ABCB1A protein results in increased export of palmatine
palmatine results in increased expression of ABCB1A mRNA		 CTD PMID:20410605 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP palmatine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO palmatine results in increased expression of AHR mRNA CTD PMID:24583342 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO palmatine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO palmatine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO palmatine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO palmatine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO palmatine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO palmatine results in increased expression of CYP1A1 mRNA CTD PMID:24583342 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO palmatine results in increased expression of H2AX protein modified form CTD PMID:23747414 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO palmatine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628 		JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO palmatine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO palmatine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
tetrahydropalmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ABCF1 protein CTD PMID:20109541 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825 		JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 increases expression ISO tetrahydropalmatine results in increased expression of ACBD3 protein CTD PMID:20109541 NCBI chr13:99,004,942...99,035,520
Ensembl chr13:99,004,942...99,035,519 		JBrowse link
G Acot9 acyl-CoA thioesterase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of ACOT9 protein CTD PMID:20109541 NCBI chr  X:43,543,069...43,592,200
Ensembl chr  X:43,543,070...43,592,200 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases expression ISO tetrahydropalmatine results in increased expression of ALDH5A1 protein CTD PMID:20109541 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413 		JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of AP2A1 protein CTD PMID:20109541 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335 		JBrowse link
G Arhgap1 Rho GTPase activating protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARHGAP1 protein CTD PMID:20109541 NCBI chr 3:80,555,196...80,576,881
Ensembl chr 3:80,555,196...80,576,856 		JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARIH1 protein CTD PMID:20109541 NCBI chr 8:64,166,359...64,268,555
Ensembl chr 8:64,166,360...64,268,555 		JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPC3 protein CTD PMID:20109541 NCBI chr12:39,653,951...39,667,817
Ensembl chr12:39,653,953...39,667,849 		JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPP19 protein CTD PMID:20109541 NCBI chr 8:81,949,577...81,972,054
Ensembl chr 8:81,949,877...81,968,589 		JBrowse link
G Atad3a ATPase family, AAA domain containing 3A increases expression ISO tetrahydropalmatine results in increased expression of ATAD3A protein CTD PMID:20109541 NCBI chr 5:173,189,590...173,209,809
Ensembl chr 5:173,189,592...173,209,768 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ATP2B1 protein CTD PMID:20109541 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO tetrahydropalmatine results in increased expression of BAD protein CTD PMID:20109541 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrahydropalmatine results in increased expression of BAX protein CTD PMID:20109541 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO tetrahydropalmatine results in decreased expression of BCAR1 protein CTD PMID:20109541 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrahydropalmatine results in decreased expression of BCL2 protein CTD PMID:20109541 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 decreases expression ISO tetrahydropalmatine results in decreased expression of BZW1 protein CTD PMID:20109541 NCBI chr 9:65,279,675...65,293,471
Ensembl chr 9:65,279,675...65,291,651 		JBrowse link
G Cald1 caldesmon 1 decreases expression
increases expression		 ISO tetrahydropalmatine results in decreased expression of CALD1 protein
tetrahydropalmatine results in increased expression of CALD1 protein		 CTD PMID:20109541 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489 		JBrowse link
G Calu calumenin decreases expression ISO tetrahydropalmatine results in decreased expression of CALU protein CTD PMID:20109541 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO tetrahydropalmatine results in increased cleavage of CASP3 protein CTD PMID:20109541 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cavin3 caveolae associated protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of CAVIN3 protein CTD PMID:20109541 NCBI chr 1:170,317,099...170,318,688
Ensembl chr 1:170,317,113...170,318,935 		JBrowse link
G Cc2d1b coiled-coil and C2 domain containing 1B decreases expression ISO tetrahydropalmatine results in decreased expression of CC2D1B protein CTD PMID:20109541 NCBI chr 5:128,215,711...128,229,762
Ensembl chr 5:128,215,711...128,229,737 		JBrowse link
G Ckap5 cytoskeleton associated protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of CKAP5 protein CTD PMID:20109541 NCBI chr 3:80,424,320...80,526,583
Ensembl chr 3:80,468,154...80,526,593 		JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of CLIP1 protein CTD PMID:20109541 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652 		JBrowse link
G Coa6 cytochrome c oxidase assembly factor 6 decreases expression ISO tetrahydropalmatine results in decreased expression of COA6 protein CTD PMID:20109541 NCBI chr19:59,327,328...59,333,706
Ensembl chr19:59,328,960...59,331,192 		JBrowse link
G Coasy Coenzyme A synthase decreases expression ISO tetrahydropalmatine results in decreased expression of COASY protein CTD PMID:20109541 NCBI chr10:88,992,413...88,996,677
Ensembl chr10:88,992,487...88,996,676 		JBrowse link
G Cops2 COP9 signalosome subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS2 protein CTD PMID:20109541 NCBI chr 3:118,109,394...118,137,125
Ensembl chr 3:118,109,406...118,137,191 		JBrowse link
G Cops3 COP9 signalosome subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS3 protein CTD PMID:20109541 NCBI chr10:46,182,680...46,206,083
Ensembl chr10:46,182,687...46,206,135 		JBrowse link
G Cox6c cytochrome c oxidase subunit 6C increases expression ISO tetrahydropalmatine results in increased expression of COX6C protein CTD PMID:20109541 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO tetrahydropalmatine results in decreased expression of CPT1A protein CTD PMID:20109541 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CRIP2 protein CTD PMID:20109541 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490 		JBrowse link
G Cryz crystallin zeta decreases expression ISO tetrahydropalmatine results in decreased expression of CRYZ protein CTD PMID:20109541 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792 		JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO tetrahydropalmatine results in decreased expression of CSDE1 protein CTD PMID:20109541 NCBI chr 2:205,525,194...205,552,987
Ensembl chr 2:205,525,204...205,552,991 		JBrowse link
G Cstb cystatin B increases expression ISO tetrahydropalmatine results in increased expression of CSTB protein CTD PMID:20109541 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CYP1A2 mRNA; tetrahydropalmatine results in decreased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Dcaf7 DDB1 and CUL4 associated factor 7 decreases expression ISO tetrahydropalmatine results in decreased expression of DCAF7 protein CTD PMID:20109541 NCBI chr10:94,231,585...94,254,046
Ensembl chr10:94,231,585...94,254,046 		JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DCTN2 protein CTD PMID:20109541 NCBI chr 7:70,555,953...70,571,433
Ensembl chr 7:70,556,019...70,572,614 		JBrowse link
G Ddx19b DEAD-box helicase 19B decreases expression ISO tetrahydropalmatine results in decreased expression of DDX19B protein CTD PMID:20109541 NCBI chr19:43,217,199...43,246,196
Ensembl chr19:43,217,161...43,275,287 		JBrowse link
G Ddx50 DExD-box helicase 50 decreases expression ISO tetrahydropalmatine results in decreased expression of DDX50 protein CTD PMID:20109541 NCBI chr20:32,239,736...32,269,522
Ensembl chr20:32,239,748...32,269,145 		JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression ISO tetrahydropalmatine results in increased expression of DECR2 protein CTD PMID:20109541 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413 		JBrowse link
G Dhx8 DEAH-box helicase 8 increases expression ISO tetrahydropalmatine results in increased expression of DHX8 protein CTD PMID:20109541 NCBI chr10:89,645,979...89,683,839
Ensembl chr10:89,645,973...89,683,446 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 decreases expression ISO tetrahydropalmatine results in decreased expression of DNAJB11 protein CTD PMID:20109541 NCBI chr11:81,741,342...81,757,806
Ensembl chr11:81,741,297...81,757,813 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 decreases expression ISO tetrahydropalmatine results in decreased expression of DPP3 protein CTD PMID:20109541 NCBI chr 1:220,166,124...220,189,762
Ensembl chr 1:220,166,127...220,188,541 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD1 protein CTD PMID:17361394 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD2 protein CTD PMID:17361394 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Drd3 dopamine receptor D3 affects binding EXP tetrahydropalmatine binds to DRD3 protein CTD PMID:17361394 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327 		JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1I2 protein CTD PMID:20109541 NCBI chr 3:57,817,677...57,868,854
Ensembl chr 3:57,817,693...57,868,854 		JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1LI2 protein CTD PMID:20109541 NCBI chr19:740,007...762,897
Ensembl chr19:740,028...762,897 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of EEF1A1 protein CTD PMID:20109541 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO tetrahydropalmatine results in decreased expression of EEF1A2 protein CTD PMID:20109541 NCBI chr 3:176,657,104...176,666,282
Ensembl chr 3:176,657,107...176,666,282 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF1 protein CTD PMID:20109541 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765 		JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF4A2 protein CTD PMID:20109541 NCBI chr11:81,373,047...81,379,680
Ensembl chr11:81,373,048...81,379,871 		JBrowse link
G Exoc8 exocyst complex component 8 decreases expression ISO tetrahydropalmatine results in decreased expression of EXOC8 protein CTD PMID:20109541 NCBI chr19:57,647,305...57,649,794
Ensembl chr19:57,647,291...57,649,827 		JBrowse link
G Faf2 Fas associated factor family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FAF2 protein CTD PMID:20109541 NCBI chr17:10,485,650...10,527,886
Ensembl chr17:10,485,642...10,527,864 		JBrowse link
G Fah fumarylacetoacetate hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of FAH protein CTD PMID:20109541 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261 		JBrowse link
G Fam136a family with sequence similarity 136, member A decreases expression ISO tetrahydropalmatine results in decreased expression of FAM136A protein CTD PMID:20109541 NCBI chr 4:118,160,147...118,166,062
Ensembl chr 4:118,160,147...118,166,062 		JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO tetrahydropalmatine results in decreased expression of FKBP8 protein CTD PMID:20109541 NCBI chr16:20,645,956...20,652,890
Ensembl chr16:20,645,957...20,652,889 		JBrowse link
G Flywch2 FLYWCH family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FLYWCH2 protein CTD PMID:20109541
G Fmr1 FMRP translational regulator 1 decreases expression ISO tetrahydropalmatine results in decreased expression of FMR1 protein CTD PMID:20109541 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314 		JBrowse link
G Galk1 galactokinase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of GALK1 protein CTD PMID:20109541 NCBI chr10:104,560,322...104,564,499
Ensembl chr10:104,560,303...104,564,480 		JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO tetrahydropalmatine results in decreased expression of GANAB protein CTD PMID:20109541 NCBI chr 1:225,096,558...225,116,384
Ensembl chr 1:225,096,598...225,116,378 		JBrowse link
G Ggh gamma-glutamyl hydrolase increases expression ISO tetrahydropalmatine results in increased expression of GGH protein CTD PMID:20109541 NCBI chr 5:34,040,258...34,063,369
Ensembl chr 5:34,040,258...34,063,361 		JBrowse link
G Glrx glutaredoxin decreases expression ISO tetrahydropalmatine results in decreased expression of GLRX protein CTD PMID:20109541 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944 		JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO tetrahydropalmatine results in increased expression of GMPPB protein CTD PMID:20109541 NCBI chr 8:116,826,251...116,856,159
Ensembl chr 8:116,826,680...116,856,159 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GPX4 protein CTD PMID:20109541 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Gsn gelsolin decreases expression ISO tetrahydropalmatine results in decreased expression of GSN protein CTD PMID:20109541 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911 		JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GTPBP4 protein CTD PMID:20109541 NCBI chr17:63,111,086...63,145,618
Ensembl chr17:63,110,254...63,145,577 		JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase increases expression ISO tetrahydropalmatine results in increased expression of HIBCH protein CTD PMID:20109541 NCBI chr 9:53,446,185...53,526,727
Ensembl chr 9:53,446,194...53,526,728 		JBrowse link
G Hint2 histidine triad nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of HINT2 protein CTD PMID:20109541 NCBI chr 5:59,150,344...59,152,599
Ensembl chr 5:59,150,345...59,152,599 		JBrowse link
G Hk1 hexokinase 1 decreases expression
increases expression		 ISO tetrahydropalmatine results in decreased expression of HK1 protein
tetrahydropalmatine results in increased expression of HK1 protein		 CTD PMID:20109541 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649 		JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMGA1 protein CTD PMID:20109541 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMOX1 protein CTD PMID:20109541 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO tetrahydropalmatine results in increased expression of HNRNPUL2 protein CTD PMID:20109541 NCBI chr 1:225,015,722...225,027,640
Ensembl chr 1:225,015,616...225,027,710 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IGF2BP3 protein CTD PMID:20109541 NCBI chr 4:78,744,683...78,879,457
Ensembl chr 4:78,746,547...78,879,294 		JBrowse link
G Ipo9 importin 9 decreases expression ISO tetrahydropalmatine results in decreased expression of IPO9 protein CTD PMID:20109541 NCBI chr13:52,203,384...52,256,196
Ensembl chr13:52,207,435...52,256,196 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IQGAP3 protein CTD PMID:20109541 NCBI chr 2:187,447,477...187,489,630
Ensembl chr 2:187,447,501...187,489,630 		JBrowse link
G Jpt2 Jupiter microtubule associated homolog 2 decreases expression ISO tetrahydropalmatine results in decreased expression of JPT2 protein CTD PMID:20109541 NCBI chr10:14,304,108...14,324,170
Ensembl chr10:14,304,104...14,324,211 		JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of LETM1 protein CTD PMID:20109541 NCBI chr14:82,227,790...82,267,298
Ensembl chr14:82,227,708...82,267,350 		JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of LTA4H protein CTD PMID:20109541 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235 		JBrowse link
G Mak16 MAK16 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of MAK16 protein CTD PMID:20109541 NCBI chr16:64,729,254...64,737,807
Ensembl chr16:64,729,221...64,737,807 		JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 increases expression ISO tetrahydropalmatine results in increased expression of MAN1B1 protein CTD PMID:20109541 NCBI chr 3:2,547,259...2,569,051
Ensembl chr 3:2,547,986...2,569,049 		JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO tetrahydropalmatine results in increased expression of MAP1B protein CTD PMID:20109541 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of MAP2K2 protein CTD PMID:20109541 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489 		JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of METAP2 protein CTD PMID:20109541 NCBI chr 7:34,762,241...34,789,456
Ensembl chr 7:34,762,231...34,789,479 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO tetrahydropalmatine results in decreased expression of MTOR protein CTD PMID:20109541 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO tetrahydropalmatine results in increased expression of NCAPH protein CTD PMID:20109541 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of NCEH1 protein CTD PMID:20109541 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953 		JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 decreases expression ISO tetrahydropalmatine results in decreased expression of NDUFB5 protein CTD PMID:20109541 NCBI chr 2:119,139,717...119,153,753
Ensembl chr 2:119,139,717...119,153,753 		JBrowse link
G Nelfe negative elongation factor complex member E decreases expression ISO tetrahydropalmatine results in decreased expression of NELFE protein CTD PMID:20109541 NCBI chr20:4,530,328...4,536,085
Ensembl chr20:4,530,342...4,536,209 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression ISO tetrahydropalmatine results in decreased expression of NFU1 protein CTD PMID:20109541 NCBI chr 4:118,814,284...118,834,955
Ensembl chr 4:118,814,284...118,834,955 		JBrowse link
G Nipsnap1 nipsnap homolog 1 increases expression ISO tetrahydropalmatine results in increased expression of NIPSNAP1 protein CTD PMID:20109541 NCBI chr14:85,113,578...85,137,457
Ensembl chr14:85,113,578...85,137,454 		JBrowse link
G Nubp2 nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUBP2 protein CTD PMID:20109541 NCBI chr10:14,244,201...14,247,930
Ensembl chr10:14,244,203...14,247,886 		JBrowse link
G Nufip2 nuclear FMR1 interacting protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUFIP2 protein CTD PMID:20109541 NCBI chr10:65,168,145...65,200,210
Ensembl chr10:65,176,648...65,200,109 		JBrowse link
G Nup155 nucleoporin 155 decreases expression ISO tetrahydropalmatine results in decreased expression of NUP155 protein CTD PMID:20109541 NCBI chr 2:57,206,665...57,258,242
Ensembl chr 2:57,206,613...57,258,295 		JBrowse link
G Palld palladin, cytoskeletal associated protein decreases expression ISO tetrahydropalmatine results in decreased expression of PALLD protein CTD PMID:20109541 NCBI chr16:31,865,712...31,948,168 JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO tetrahydropalmatine results in decreased expression of PAWR protein CTD PMID:20109541 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068 		JBrowse link
G Pds5a PDS5 cohesin associated factor A increases expression ISO tetrahydropalmatine results in increased expression of PDS5A protein CTD PMID:20109541 NCBI chr14:44,185,445...44,282,308
Ensembl chr14:44,185,446...44,280,079 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO tetrahydropalmatine results in increased expression of PICALM protein CTD PMID:20109541 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PIN1 protein CTD PMID:20109541 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615 		JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 decreases expression ISO tetrahydropalmatine results in decreased expression of PPIL3 protein CTD PMID:20109541 NCBI chr 9:65,315,407...65,329,145
Ensembl chr 9:65,315,410...65,329,066 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO tetrahydropalmatine results in decreased expression of PPP2CB protein CTD PMID:20109541 NCBI chr16:62,273,276...62,294,767
Ensembl chr16:62,273,276...62,294,769 		JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO tetrahydropalmatine results in increased expression of PRAF2 protein CTD PMID:20109541 NCBI chr  X:15,618,324...15,620,992
Ensembl chr  X:15,618,991...15,620,841 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKAR1A protein CTD PMID:20109541 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336 		JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKCA protein CTD PMID:20109541 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prpf4 pre-mRNA processing factor 4 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPF4 protein CTD PMID:20109541 NCBI chr 5:78,267,248...78,281,172
Ensembl chr 5:78,267,248...78,281,172 		JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPSAP1 protein CTD PMID:20109541 NCBI chr10:105,430,516...105,492,154
Ensembl chr10:105,430,520...105,452,228 		JBrowse link
G Pym1 PYM homolog 1, exon junction complex associated factor decreases expression ISO tetrahydropalmatine results in decreased expression of PYM1 protein CTD PMID:20109541 NCBI chr 7:3,172,798...3,193,994
Ensembl chr 7:3,173,287...3,193,994 		JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 decreases expression ISO tetrahydropalmatine results in decreased expression of RAB3GAP1 protein CTD PMID:20109541 NCBI chr13:44,578,208...44,649,876
Ensembl chr13:44,615,553...44,648,620 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO tetrahydropalmatine results in increased expression of RAF1 protein CTD PMID:20109541 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Ranbp2 RAN binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of RANBP2 protein CTD PMID:20109541 NCBI chr20:28,027,054...28,076,664
NCBI chr20:28,365,538...28,375,676
Ensembl chr20:28,027,054...28,076,664
Ensembl chr20:28,027,054...28,076,664 		JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression
increases expression		 ISO tetrahydropalmatine results in decreased expression of RBM39 protein
tetrahydropalmatine results in increased expression of RBM39 protein		 CTD PMID:20109541 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654
Ensembl chr 3:151,691,514...151,724,654 		JBrowse link
G Reep5 receptor accessory protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of REEP5 protein CTD PMID:20109541 NCBI chr18:27,128,462...27,159,693
Ensembl chr18:27,128,464...27,159,693 		JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO tetrahydropalmatine results in increased expression of RFC4 protein CTD PMID:20109541 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043 		JBrowse link
G Rhob ras homolog family member B decreases expression ISO tetrahydropalmatine results in decreased expression of RHOB protein CTD PMID:20109541 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301 		JBrowse link
G Rmnd5a required for meiotic nuclear division 5 homolog A increases expression ISO tetrahydropalmatine results in increased expression of RMND5A protein CTD PMID:20109541 NCBI chr 4:99,249,159...99,305,805
Ensembl chr 4:99,253,633...99,305,812 		JBrowse link
G Rnf40 ring finger protein 40 decreases expression ISO tetrahydropalmatine results in decreased expression of RNF40 protein CTD PMID:20109541 NCBI chr 1:199,037,472...199,052,823
Ensembl chr 1:199,037,544...199,052,172 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of ROCK2 protein CTD PMID:20109541 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908 		JBrowse link
G Rpa2 replication protein A2 decreases expression ISO tetrahydropalmatine results in decreased expression of RPA2 protein CTD PMID:20109541 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269 		JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO tetrahydropalmatine results in decreased expression of RPS28 protein CTD PMID:20109541 NCBI chr 7:18,682,071...18,683,440
Ensembl chr 7:18,682,071...18,683,440 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression ISO tetrahydropalmatine results in increased expression of RPS6KA3 protein CTD PMID:20109541 NCBI chr  X:37,469,736...37,576,055
Ensembl chr  X:37,469,937...37,575,624 		JBrowse link
G Septin11 septin 11 decreases expression ISO tetrahydropalmatine results in decreased expression of SEPTIN11 protein CTD PMID:20109541 NCBI chr14:16,369,544...16,405,645
Ensembl chr14:16,369,544...16,452,998 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] CTD PMID:23831208 PMID:24799337 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc25a10 solute carrier family 25 member 10 increases expression ISO tetrahydropalmatine results in increased expression of SLC25A10 protein CTD PMID:20109541 NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143 		JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 decreases expression ISO tetrahydropalmatine results in decreased expression of SMARCA5 protein CTD PMID:20109541 NCBI chr19:30,936,703...30,969,454
Ensembl chr19:30,936,703...30,969,454 		JBrowse link
G Sms spermine synthase decreases expression ISO tetrahydropalmatine results in decreased expression of SMS protein CTD PMID:20109541 NCBI chr  X:40,363,646...40,415,110
Ensembl chr  X:40,363,646...40,415,109 		JBrowse link
G Sncg synuclein, gamma decreases expression ISO tetrahydropalmatine results in decreased expression of SNCG protein CTD PMID:20109541 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707 		JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E decreases expression ISO tetrahydropalmatine results in decreased expression of SNRPE protein CTD PMID:20109541 NCBI chr13:50,252,707...50,258,951
Ensembl chr 8:129,371,556...129,371,973 		JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNW1 protein CTD PMID:20109541 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782 		JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX1 protein CTD PMID:20109541 NCBI chr 8:71,745,687...71,786,182
Ensembl chr 8:71,745,896...71,784,551 		JBrowse link
G Snx2 sorting nexin 2 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX2 protein CTD PMID:20109541 NCBI chr18:48,132,386...48,173,974
Ensembl chr18:48,132,414...48,173,971 		JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SPDL1 protein CTD PMID:20109541 NCBI chr10:19,628,070...19,652,914
Ensembl chr10:19,628,258...19,652,898 		JBrowse link
G Sri sorcin decreases expression ISO tetrahydropalmatine results in decreased expression of SRI protein CTD PMID:20109541 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983 		JBrowse link
G Srp19 signal recognition particle 19 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP19 protein CTD PMID:20109541 NCBI chr18:27,114,822...27,121,062
Ensembl chr18:27,114,822...27,121,059 		JBrowse link
G Srp68 signal recognition particle 68 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP68 protein CTD PMID:20109541 NCBI chr10:105,123,324...105,150,080
Ensembl chr10:105,123,327...105,228,547 		JBrowse link
G Srpra SRP receptor subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of SRPRA protein CTD PMID:20109541 NCBI chr 8:36,410,683...36,416,766
Ensembl chr 8:36,410,683...36,416,296 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO tetrahydropalmatine results in increased expression of STAT1 protein CTD PMID:20109541 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of STXBP1 protein CTD PMID:20109541 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417 		JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 increases expression ISO tetrahydropalmatine results in increased expression of SWAP70 protein CTD PMID:20109541 NCBI chr 1:174,862,683...174,924,101
Ensembl chr 1:174,862,698...174,924,078 		JBrowse link
G Syvn1 synoviolin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SYVN1 protein CTD PMID:20109541 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886 		JBrowse link
G Tma7 translation machinery associated 7 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of TMA7 protein CTD PMID:20109541 NCBI chr 8:117,815,725...117,820,422
Ensembl chr 8:117,815,725...117,820,413 		JBrowse link
G Tmed4 transmembrane p24 trafficking protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of TMED4 protein CTD PMID:20109541 NCBI chr14:86,390,327...86,395,151
Ensembl chr14:86,390,338...86,395,135 		JBrowse link
G Top1 DNA topoisomerase I increases expression ISO tetrahydropalmatine results in increased expression of TOP1 protein CTD PMID:20109541 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686 		JBrowse link
G Tsnax translin-associated factor X decreases expression ISO tetrahydropalmatine results in decreased expression of TSNAX protein CTD PMID:20109541 NCBI chr19:57,771,539...57,785,567
Ensembl chr19:57,771,398...57,785,543 		JBrowse link
G Tsr2 TSR2, ribosome maturation factor increases expression ISO tetrahydropalmatine results in increased expression of TSR2 protein CTD PMID:20109541 NCBI chr  X:20,141,406...20,146,082
Ensembl chr  X:20,144,432...20,232,639 		JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 decreases expression ISO tetrahydropalmatine results in decreased expression of TTC37 protein CTD PMID:20109541 NCBI chr 2:2,891,265...3,037,602
Ensembl chr 2:2,903,492...3,004,553 		JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO tetrahydropalmatine results in increased expression of UAP1 protein CTD PMID:20109541 NCBI chr13:88,463,532...88,497,901
Ensembl chr13:88,463,532...88,497,901 		JBrowse link
G Vps45 vacuolar protein sorting 45 homolog increases expression ISO tetrahydropalmatine results in increased expression of VPS45 protein CTD PMID:20109541 NCBI chr 2:198,123,747...198,184,739
Ensembl chr 2:198,123,748...198,184,739 		JBrowse link
G Wdhd1 WD repeat and HMG-box DNA binding protein 1 increases expression ISO tetrahydropalmatine results in increased expression of WDHD1 protein CTD PMID:20109541 NCBI chr15:24,021,674...24,056,073
Ensembl chr15:24,021,674...24,056,073 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            alkaloid 5624
              isoquinoline alkaloid 1135
                berberine alkaloid 359
                  (S)-cheilanthifoline 0
                  (S)-cis-N-methylstylopine 0
                  (S)-nandinine + 0
                  (S)-scoulerine + 0
                  (S)-stylopine + 0
                  (S)-tetrahydrocolumbamine 0
                  2,3,9,10-tetrahydroxyberbine 0
                  berberine 209
                  berbine + 0
                  canadine + 2
                  columbamine + 8
                  cyclanoline 0
                  palmatine + 159
                  stepharanine 0
                  tetrahydropalmatine 147
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organonitrogen heterocyclic compound 17521
                                    dibenzoquinolizine 359
                                      berberine alkaloid 359
                                        (S)-cheilanthifoline 0
                                        (S)-cis-N-methylstylopine 0
                                        (S)-nandinine + 0
                                        (S)-scoulerine + 0
                                        (S)-stylopine + 0
                                        (S)-tetrahydrocolumbamine 0
                                        2,3,9,10-tetrahydroxyberbine 0
                                        berberine 209
                                        berbine + 0
                                        canadine + 2
                                        columbamine + 8
                                        cyclanoline 0
                                        palmatine + 159
                                        stepharanine 0
                                        tetrahydropalmatine 147
paths to the root