benzoquinones - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	benzoquinones	go back to main search page
Accession:	CHEBI:22729	browse the term
Definition:	Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives.
Synonyms:	xref_mesh:	MESH:D016227

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Rat (783) Mouse (782) Human (801) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (782)

benzoquinones

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apurinic/apyrimidinic endonuclease 1

multiple interactions

APEX1 protein results in increased reduction of and results in increased susceptibility to Benzoquinones

NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596

G

catalase

increases expression
affects response to substance
increases activity

Benzoquinones results in increased expression of CAT mRNA
CAT protein affects the susceptibility to Benzoquinones
Benzoquinones results in increased activity of CAT protein

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Benzoquinones analog results in increased expression of GCLC protein

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

increases expression

Benzoquinones analog results in increased expression of GCLM protein

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

glutathione S-transferase, alpha 3

increases expression

Benzoquinones analog results in increased expression of GSTA1 protein

NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885

G

heme oxygenase 1

increases expression

Benzoquinones analog results in increased expression of HMOX1 protein

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

kelch-like ECH-associated protein 1

multiple interactions

Benzoquinones analog binds to and results in increased metabolism of KEAP1 protein

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
decreases response to substance

Benzoquinones analog results in increased activity of and affects the localization of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Benzoquinones analog

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

NAD(P)H dehydrogenase, quinone 1

increases expression
affects response to substance
increases activity

Benzoquinones analog results in increased expression of NQO1 protein
NQO1 protein affects the susceptibility to Benzoquinones
Benzoquinones results in increased activity of NQO1 protein

PMID:3127038 PMID:21651925

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

multiple interactions

Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog binds to and results in increased oxidation of SULT2A1 protein; Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]

NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334

1,2-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl-hydrocarbon receptor

affects localization
multiple interactions

2-benzoquinone affects the localization of AHR protein
[2-benzoquinone co-treated with 1,4-naphthoquinone] affects the localization of AHR protein

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

albumin

multiple interactions
affects binding

Benzene promotes the reaction [2-benzoquinone binds to ALB protein]
Benzene promotes the reaction [ALB protein binds to 2-benzoquinone]

PMID:9826945 PMID:17366815

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

1,4-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acyltransferase 2

decreases expression

quinone results in decreased expression of ACAA2 mRNA

NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279

G

acyl-Coenzyme A dehydrogenase, very long chain

decreases expression

quinone results in decreased expression of ACADVL mRNA

NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237

G

aryl-hydrocarbon receptor

multiple interactions
affects localization

AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]
quinone affects the localization of AHR protein

PMID:26558468 PMID:27853106

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

aldo-keto reductase family 1, member C21

increases expression

quinone results in increased expression of AKR1C2 mRNA

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

albumin

affects binding
multiple interactions

ALB protein binds to quinone; quinone binds to ALB protein
Benzene promotes the reaction [ALB protein binds to quinone]
Benzene promotes the reaction [quinone binds to ALB protein]; quinone inhibits the reaction [ALB protein binds to Bromcresol Green]

PMID:9826945 PMID:10746935 PMID:11489749 PMID:11888901 PMID:16484134 More...

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

alkB homolog 5, RNA demethylase

increases expression

quinone results in increased expression of ALKBH5 mRNA

NCBI chr11:60,428,509...60,449,338
Ensembl chr11:60,427,207...60,449,338

G

BTB and CNC homology 1, basic leucine zipper transcription factor 1

multiple interactions
affects localization

quinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]
quinone affects the localization of BACH1 protein

NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234

G

BCL2-associated X protein

increases expression

quinone results in increased expression of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression
multiple interactions

quinone results in decreased expression of BCL2 protein
[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein

PMID:20499891 PMID:30448556

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

beclin 1, autophagy related

increases expression
multiple interactions

quinone results in increased expression of BECN1 protein
Cyclosporine inhibits the reaction [quinone results in increased expression of BECN1 protein]

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

Bmi1 polycomb ring finger oncogene

increases expression

quinone results in increased expression of BMI1 mRNA

NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440

G

caspase 1

decreases activity

quinone results in decreased activity of CASP1 protein

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

decreases activity
increases expression
multiple interactions
increases activity

quinone results in decreased activity of CASP3 protein
quinone analog results in increased expression of CASP3 protein modified form
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]
[quinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]

PMID:15337166 PMID:17051661 PMID:20499891 PMID:22960397 PMID:32478940 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

decreases activity

quinone results in decreased activity of CASP7 protein

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

increases activity
multiple interactions

quinone results in increased activity of CASP8 protein
Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein]

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions
increases activity
increases expression

Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of CASP9 protein]

PMID:29567065 PMID:32478940

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions
decreases response to substance
increases expression

CAT protein inhibits the reaction [quinone results in increased abundance of Reactive Oxygen Species]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CAT protein results in decreased susceptibility to quinone
quinone results in increased expression of CAT protein

PMID:10193577 PMID:15795063 PMID:25437431

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 11

increases expression

quinone results in increased expression of CCL11 protein

NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781

G

C-C motif chemokine ligand 2

increases expression

quinone results in increased expression of CCL2 protein

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 3

increases expression

quinone results in increased expression of CCL3 protein

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

C-C motif chemokine ligand 4

increases expression

quinone results in increased expression of CCL4 protein

NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509

G

C-C motif chemokine ligand 5

increases expression

quinone results in increased expression of CCL5 protein

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

cyclin D1

decreases expression
multiple interactions

quinone results in decreased expression of CCND1 protein
MECOM protein affects the reaction [quinone results in decreased expression of CCND1 protein]

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

CD80 antigen

increases expression

quinone results in increased expression of CD80 protein

NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697

G

CD86 antigen

increases expression

quinone results in increased expression of CD86 protein

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cyclin dependent kinase inhibitor 1A

increases expression
multiple interactions

quinone results in increased expression of CDKN1A mRNA
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; TRP53 promotes the reaction [quinone analog results in increased expression of CDKN1A protein]

PMID:14976336 PMID:33961949

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

carnitine palmitoyltransferase 1a, liver

multiple interactions
decreases expression

Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein]
quinone results in decreased expression of CPT1A mRNA; quinone results in decreased expression of CPT1A protein

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

carnitine palmitoyltransferase 2

decreases expression

quinone results in decreased expression of CPT2 mRNA

NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807

G

carnitine acetyltransferase

decreases expression

quinone results in decreased expression of CRAT mRNA

NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825

G

crystallin, alpha A

multiple interactions

quinone binds to and affects the folding of CRYAA protein

NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707

G

colony stimulating factor 1 receptor

multiple interactions

quinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221

G

colony stimulating factor 2 (granulocyte-macrophage)

multiple interactions

quinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

C-X-C motif chemokine ligand 12

increases expression

quinone results in increased expression of CXCL12 mRNA

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

C-X-C motif chemokine ligand 15

increases expression
increases secretion

quinone results in increased expression of CXCL8 mRNA; quinone results in increased expression of CXCL8 protein
quinone results in increased secretion of CXCL8 protein

PMID:17572062 PMID:20541004 PMID:23724284 PMID:31958493

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

quinone results in increased expression of CYP1A1 mRNA
AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]

PMID:20491607 PMID:26558468 PMID:27853106

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

quinone results in decreased expression of CYP2E1 protein

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

dehydrogenase/reductase 7

increases reduction

DHRS7 protein results in increased reduction of quinone

NCBI chr12:72,697,127...72,711,678
Ensembl chr12:72,697,127...72,711,683

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

quinone results in increased expression of DKK1 mRNA

NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065

G

epidermal growth factor receptor

multiple interactions

quinone promotes the reaction [1,4-naphthoquinone results in increased phosphorylation of EGFR protein]

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

FTO alpha-ketoglutarate dependent dioxygenase

decreases expression

quinone results in decreased expression of FTO mRNA

NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067

G

GATA binding protein 3

increases expression

quinone results in increased expression of GATA3 mRNA

NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845

G

guanylate binding protein 2b

multiple interactions

quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]

NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940

G

glutamate-cysteine ligase, modifier subunit

increases expression

quinone results in increased expression of GCLM protein

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

glutathione synthetase

increases expression
multiple interactions

quinone results in increased expression of GSS protein
NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]

NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730

G

H2A.X variant histone

increases phosphorylation
multiple interactions
increases expression

quinone results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]

PMID:18835433 PMID:31340051 PMID:33961949

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression
multiple interactions

quinone results in decreased expression of HADHA mRNA; quinone results in decreased expression of HADHA protein
Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein]

NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160

G

hypoxia inducible factor 1, alpha subunit

multiple interactions
increases expression

[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein; [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein; [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKL protein; [HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PKM protein; [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein
quinone results in increased expression of HIF1A protein

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

increases expression
multiple interactions

quinone results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased expression of HMOX1 protein]; AG 1879 inhibits the reaction [quinone results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [quinone results in increased expression of HMOX1 protein]
NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]

PMID:21059386 PMID:23290930 PMID:25437431 PMID:28645578

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

homeobox B4

increases expression

quinone results in increased expression of HOXB4 mRNA

NCBI chr11:96,209,093...96,212,464
Ensembl chr11:96,209,093...96,212,464

G

interferon gamma

multiple interactions

[IFNG protein co-treated with Lipopolysaccharides co-treated with quinone] results in increased abundance of Nitric Oxide; quinone inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of IFNG protein]
quinone promotes the reaction [IFNG protein results in increased expression of APOL1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]; quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

PMID:3137358 PMID:7884313 PMID:31248982

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

insulin-like growth factor 2 mRNA binding protein 1

decreases expression

quinone results in decreased expression of IGF2BP1 mRNA

NCBI chr11:95,847,989...95,896,770
Ensembl chr11:95,847,989...95,896,766

G

insulin-like growth factor 2 mRNA binding protein 3

decreases expression

quinone results in decreased expression of IGF2BP3 mRNA

NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891

G

interleukin 10

multiple interactions
increases secretion

quinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein]
quinone results in increased secretion of IL10 protein

PMID:17572062 PMID:31958493

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 12b

increases secretion

quinone results in increased secretion of IL12B protein

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

G

interleukin 6

increases expression

quinone results in increased expression of IL6 protein

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interferon regulatory factor 1

multiple interactions

quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]

NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200

G

jagged 1

decreases expression

quinone results in decreased expression of JAG1 mRNA

NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564

G

kinase insert domain protein receptor

multiple interactions

quinone analog binds to and results in decreased activity of KDR protein

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

kit ligand

increases expression

quinone results in increased expression of KITLG mRNA

NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278

G

lactate dehydrogenase A

increases expression
multiple interactions

quinone results in increased expression of LDHA protein
[HIF1A protein co-treated with quinone] results in increased expression of LDHA protein

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

increases expression

quinone results in increased expression of MAFF mRNA

NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276

G

mitogen-activated protein kinase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

microtubule-associated protein tau

multiple interactions

quinone promotes the reaction [MAPT protein binds to MAPT protein]

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

MDS1 and EVI1 complex locus

decreases expression
multiple interactions

quinone results in decreased expression of MECOM protein
MECOM protein affects the reaction [quinone results in decreased expression of CCND1 protein]; MECOM protein affects the reaction [quinone results in decreased phosphorylation of MTOR protein]

NCBI chr 3:30,005,445...30,563,937
Ensembl chr 3:30,005,445...30,602,157

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

decreases expression

quinone results in decreased expression of METTL3 mRNA

NCBI chr14:52,532,298...52,548,555
Ensembl chr14:52,532,298...52,542,585

G

myeloperoxidase

multiple interactions

[[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; [[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

metallothionein 1

increases expression

quinone results in increased expression of MT1 mRNA

NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

MECOM protein affects the reaction [quinone results in decreased phosphorylation of MTOR protein]

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

myeloblastosis oncogene

increases activity
multiple interactions

quinone results in increased activity of MYB protein
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]

NCBI chr10:21,000,829...21,036,883
Ensembl chr10:21,000,834...21,036,883

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression

NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]; NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]; quinone affects the localization of and results in increased degradation of NFE2L2 protein; quinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; quinone results in increased expression of and affects the localization of NFE2L2 protein
quinone results in increased expression of NFE2L2 mRNA
quinone results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein

PMID:21059386 PMID:25437431 PMID:26862668 PMID:28645578

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

NADPH oxidase 1

multiple interactions
increases expression

[quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species

NCBI chr X:132,987,170...133,038,455
Ensembl chr X:132,987,170...133,122,705

G

NADPH oxidase 4

decreases expression

quinone results in decreased expression of NOX4 protein

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

NAD(P)H dehydrogenase, quinone 1

increases expression

quinone results in increased expression of NQO1 protein
quinone results in increased expression of NQO1 mRNA; quinone results in increased expression of NQO1 protein

PMID:8652659 PMID:20491607 PMID:21059386 PMID:25437431 PMID:28645578

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

8-oxoguanine DNA-glycosylase 1

decreases expression

quinone results in decreased expression of OGG1 mRNA

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

pyruvate dehydrogenase kinase, isoenzyme 1

multiple interactions

[HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein

NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions
increases expression

[HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein
quinone results in increased expression of PFKFB3 protein

NCBI chr 2:11,476,241...11,558,882
Ensembl chr 2:11,476,244...11,558,888

G

phosphofructokinase, liver, B-type

multiple interactions
increases expression

[HIF1A protein co-treated with quinone] results in increased expression of PFKL protein
quinone results in increased expression of PFKL protein

NCBI chr10:77,822,781...77,845,641
Ensembl chr10:77,822,781...77,845,917

G

phosphoglycerate kinase 1

multiple interactions
increases expression

[HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein
quinone results in increased expression of PGK1 protein

NCBI chr X:105,230,706...105,247,305
Ensembl chr X:105,230,706...105,247,305

G

PTEN induced putative kinase 1

increases expression
multiple interactions

quinone results in increased expression of PINK1 mRNA; quinone results in increased expression of PINK1 protein
Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 protein]

NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618

G

pyruvate kinase, muscle

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [quinone results in increased degradation of PKM protein]; quinone results in increased degradation of and results in decreased expression of PKM protein; Reactive Oxygen Species affects the reaction [quinone results in increased degradation of PKM protein]
[HIF1A protein co-treated with quinone] results in increased expression of PKM protein
quinone results in increased expression of PKM protein

PMID:25437431 PMID:30448556

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

protein kinase C, beta

increases expression

quinone results in increased expression of PRKCB protein

NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625

G

parkin RBR E3 ubiquitin protein ligase

increases expression
multiple interactions

quinone results in increased expression of PRKN mRNA; quinone results in increased expression of PRKN protein
Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN protein]

NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248

G

protein tyrosine phosphatase, non-receptor type 1

decreases activity

quinone results in decreased activity of PTPN1 protein

NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305

G

protein tyrosine phosphatase, non-receptor type 2

multiple interactions

[[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein]; quinone binds to and results in decreased activity of PTPN2 protein; Vanadates inhibits the reaction [quinone results in decreased activity of PTPN2 protein]

NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665

G

runt related transcription factor 2

increases expression

quinone results in increased expression of RUNX2 mRNA

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

solute carrier family 2 (facilitated glucose transporter), member 1

multiple interactions

[HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

superoxide dismutase 1, soluble

increases expression

quinone results in increased expression of SOD1 protein

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

increases expression

quinone results in increased expression of SOD2 protein

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

sequestosome 1

multiple interactions
decreases expression

Cyclosporine inhibits the reaction [quinone results in decreased expression of SQSTM1 protein]

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

Rous sarcoma oncogene

increases phosphorylation

quinone results in increased phosphorylation of SRC protein

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

signal transducer and activator of transcription 1

multiple interactions

quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

tumor necrosis factor

multiple interactions

quinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

topoisomerase (DNA) II alpha

affects activity
decreases activity
increases expression
multiple interactions
increases activity

quinone affects the activity of TOP2A protein; quinone metabolite affects the activity of TOP2A protein
quinone results in decreased activity of TOP2A protein
quinone results in increased expression of TOP2A mRNA
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]; quinone binds to and affects the activity of TOP2A protein; quinone binds to and results in decreased activity of TOP2A protein
quinone results in increased activity of TOP2A protein

PMID:7586126 PMID:9118903 PMID:9118913 PMID:11468185 PMID:15833037 More...

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

topoisomerase (DNA) II beta

affects activity

quinone affects the activity of TOP2B protein

NCBI chr14:6,038,976...6,104,585
Ensembl chr14:6,034,301...6,104,584

G

transformation related protein 53

increases expression
multiple interactions

quinone results in increased expression of TP53 protein
quinone analog results in increased expression of TRP53 protein modified form
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein modified form]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein]; quinone analog results in increased expression of and affects the localization of TRP53 protein; TRP53 inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; TRP53 promotes the reaction [quinone analog results in increased expression of CDKN1A protein]

PMID:20499891 PMID:33961949

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

wingless-type MMTV integration site family, member 5A

increases expression

quinone results in increased expression of WNT5A mRNA

NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405

G

YTH domain containing 2

decreases expression

quinone results in decreased expression of YTHDC2 mRNA

NCBI chr18:44,961,521...45,022,782
Ensembl chr18:44,960,813...45,022,791

G

YTH N6-methyladenosine RNA binding protein 1

increases expression

quinone results in increased expression of YTHDF1 mRNA

NCBI chr 2:180,546,170...180,562,729
Ensembl chr 2:180,546,170...180,562,742

G

YTH N6-methyladenosine RNA binding protein 2

increases expression

quinone results in increased expression of YTHDF2 mRNA

NCBI chr 4:131,912,227...131,939,567
Ensembl chr 4:131,912,223...131,939,614

2,5-bis(aziridin-1-yl)-1,4-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]
ethylenimine quinone results in increased expression of CDKN1A mRNA; ethylenimine quinone results in increased expression of CDKN1A protein

PMID:8943236 PMID:9343371 PMID:9586815

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

6-decylubiquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

dihydroorotate dehydrogenase

increases metabolic processing
multiple interactions

DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone]

NCBI chr 8:110,319,876...110,335,330
Ensembl chr 8:110,317,975...110,335,305

coenzyme Q10

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thymoma viral proto-oncogene 1

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]

PMID:27087047 PMID:27345130 PMID:32383521

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

apoptotic peptidase activating factor 1

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

amyloid beta precursor protein

multiple interactions
decreases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]

PMID:22186599 PMID:32383521

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA]

NCBI chr 5:62,759,788...62,923,874
Ensembl chr 5:62,759,788...62,923,502

G

BCL2-associated agonist of cell death

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-antagonist/killer 1

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein]

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]

PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 PMID:34186417

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

increases expression
multiple interactions

coenzyme Q10 results in increased expression of BCL2 mRNA
[coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]

PMID:18817789 PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 More...

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

complement component 1, q subcomponent, alpha polypeptide

decreases expression

coenzyme Q10 results in decreased expression of C1QA mRNA

NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114

G

complement C4B (Chido blood group)

decreases expression

coenzyme Q10 results in decreased expression of C4B mRNA

NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856

G

caspase 3

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]

PMID:20510337 PMID:22186599 PMID:27087047 PMID:32116774 PMID:33393703 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein]

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of CAT mRNA]
[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of CAT mRNA]

PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 More...

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cellular communication network factor 2

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein]

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

cyclin D1

increases expression

coenzyme Q10 results in increased expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

collagen, type I, alpha 1

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein]

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

catenin beta 1

multiple interactions

coenzyme Q10 inhibits the reaction [Acetaminophen affects the phosphorylation of and affects the localization of CTNNB1 protein]

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cathepsin B

multiple interactions

coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSB protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSB mRNA]

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin D

multiple interactions

coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSD protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSD mRNA]

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

cathepsin S

decreases expression

coenzyme Q10 results in decreased expression of CTSS mRNA

NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714

G

cytochrome c, somatic

multiple interactions

coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CYCS mRNA]

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

endothelin 1

multiple interactions

coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

epidermal growth factor receptor pathway substrate 15

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA]

NCBI chr 4:109,137,372...109,245,014
Ensembl chr 4:109,137,465...109,245,014

G

ets variant 3

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA]

NCBI chr 3:87,432,891...87,447,463
Ensembl chr 3:87,432,714...87,447,463

G

Fas associated via death domain

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein]

NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200

G

Fas ligand

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

follicle stimulating hormone receptor

multiple interactions

coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA]

NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103

G

glucose-6-phosphate dehydrogenase X-linked

multiple interactions

[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of G6PD protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

glial fibrillary acidic protein

decreases expression
multiple interactions

coenzyme Q10 results in decreased expression of GFAP mRNA
[Oxygen co-treated with coenzyme Q10] results in decreased expression of GFAP protein

PMID:19555370 PMID:35212449

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gamma-glutamyltransferase 1

multiple interactions

coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein]

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

glutamic-oxaloacetic transaminase 1, soluble

multiple interactions

coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein]

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glutamic pyruvic transaminase, soluble

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased activity of GPT protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:27174133 PMID:27387968 PMID:33271250 PMID:33393703

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

multiple interactions

coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA]
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA]

PMID:32116774 PMID:33271250

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glycogen synthase kinase 3 beta

multiple interactions

coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]

PMID:22186599 PMID:34668565

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione reductase

multiple interactions
increases expression

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GSR mRNA]
coenzyme Q10 results in increased expression of GSR mRNA

PMID:19958828 PMID:32116774 PMID:33393703

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

heme oxygenase 1

multiple interactions

coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA]

PMID:27174133 PMID:32116774

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

interleukin 10

multiple interactions
increases expression

[Valproic Acid co-treated with coenzyme Q10] inhibits the reaction [Benzene results in increased expression of IL10 protein]
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 protein]
coenzyme Q10 results in increased expression of IL10 mRNA; coenzyme Q10 results in increased expression of IL10 protein

PMID:32116774 PMID:35090963

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 1 beta

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of IL1B protein]

PMID:32116774 PMID:32383521 PMID:34939713

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin receptor substrate 1

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

potassium inwardly-rectifying channel, subfamily J, member 6

decreases abundance

KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10

NCBI chr16:94,545,839...94,798,719
Ensembl chr16:94,549,495...94,798,560

G

lysosomal-associated membrane protein 2

multiple interactions

coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of LAMP2 protein]

NCBI chr X:37,488,524...37,545,337
Ensembl chr X:37,490,234...37,545,331

G

lactate dehydrogenase C

increases activity
multiple interactions

coenzyme Q10 results in increased activity of LDHC protein
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]

NCBI chr 7:46,510,687...46,527,571
Ensembl chr 7:46,510,627...46,527,566

G

matrix metallopeptidase 2

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein]

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

multiple interactions

[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

metallothionein 3

multiple interactions

coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 protein]

NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774

G

nuclear receptor coactivator 2

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA]

NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307

G

NADH:ubiquinone oxidoreductase subunit B6

increases expression
multiple interactions

coenzyme Q10 results in increased expression of NDUFB6 protein
coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]

NCBI chr 4:40,270,591...40,279,421
Ensembl chr 4:40,270,591...40,279,421

G

NADH:ubiquinone oxidoreductase core subunit S7

increases expression

coenzyme Q10 results in increased expression of NDUFS7 protein

NCBI chr10:80,084,939...80,092,628
Ensembl chr10:80,084,955...80,092,628

G

neurofilament, light polypeptide

multiple interactions

coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of NEFL protein]

NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544

G

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]

NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression

coenzyme Q10 inhibits the reaction [lead acetate affects the localization of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in decreased expression of NFE2L2 mRNA]
coenzyme Q10 results in increased expression of NFE2L2 mRNA
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]

PMID:27174133 PMID:32116774 PMID:33271250 PMID:34939713

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nitric oxide synthase 2, inducible

multiple interactions

coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of NOS2 mRNA]

PMID:20510337 PMID:32116774

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions

coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein]

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

osteoclast associated receptor

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]

NCBI chr 7:3,612,812...3,619,156
Ensembl chr 7:3,612,812...3,619,156

G

phenylalanine hydroxylase

decreases expression

coenzyme Q10 results in decreased expression of PAH mRNA

NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998

G

proliferating cell nuclear antigen

multiple interactions
increases expression

coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA]
coenzyme Q10 results in increased expression of PCNA protein

PMID:31557371 PMID:34668565

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

PTEN induced putative kinase 1

multiple interactions

Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]

NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618

G

POU domain, class 2, transcription factor 1

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA]

NCBI chr 1:165,692,719...165,830,318
Ensembl chr 1:165,692,723...165,830,247

G

protein phosphatase 2, regulatory subunit B', gamma

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA]

NCBI chr12:110,413,532...110,549,509
Ensembl chr12:110,413,554...110,549,496

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]

NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248

G

pleckstrin and Sec7 domain containing 3

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA]

NCBI chr 8:68,141,728...68,664,740
Ensembl chr 8:68,141,734...68,664,679

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

sterile alpha and HEAT/Armadillo motif containing 1

multiple interactions

coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of SARM1 mRNA]

NCBI chr11:78,361,099...78,388,642
Ensembl chr11:78,363,156...78,388,580

G

src family associated phosphoprotein 2

decreases expression

coenzyme Q10 results in decreased expression of SKAP2 mRNA

NCBI chr 6:51,836,145...51,989,529
Ensembl chr 6:51,834,402...51,989,529

G

SMAD family member 3

multiple interactions

coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

synuclein, alpha

multiple interactions

coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]
[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein

PMID:15114628 PMID:19476553 PMID:21843543

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

G

superoxide dismutase 2, mitochondrial

affects expression
multiple interactions
increases expression

coenzyme Q10 affects the expression of SOD2 protein
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of SOD2 mRNA]
coenzyme Q10 results in increased expression of SOD2 mRNA
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA]
coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]

PMID:22083459 PMID:24008411 PMID:32116774 PMID:33271250

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

sequestosome 1

multiple interactions

Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

transforming growth factor, beta 1

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]

PMID:27087047 PMID:27174133

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tumor necrosis factor

multiple interactions

coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of TNF protein]

PMID:20510337 PMID:26519479 PMID:32116774 PMID:32383521 PMID:34939713

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor (ligand) superfamily, member 11

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein]

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

TNF receptor-associated factor 2

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein]

NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952

G

transformation related protein 53

multiple interactions

coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased phosphorylation of TP53 protein]

PMID:20510337 PMID:33393703

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

diaziquone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase inhibitor 1A

increases expression
multiple interactions

diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]

PMID:8943236 PMID:9343371

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

microtubule-associated protein tau

decreases expression

diaziquone results in decreased expression of MAPT protein

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

NAD(P)H dehydrogenase, quinone 1

decreases activity
increases metabolic processing
multiple interactions

[Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
NQO1 protein results in increased metabolism of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone

PMID:2113030 PMID:9343371

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

docebenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 12-lipoxygenase

decreases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX12 protein

NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179

G

arachidonate 5-lipoxygenase

decreases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein

PMID:2724698 PMID:7812673 PMID:25432964

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

caspase 3

multiple interactions
increases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of CASP3 protein

PMID:22308955 PMID:25432964

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

hydroxysteroid 11-beta dehydrogenase 2

increases activity
multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein
[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]

NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620

G

interleukin 6

multiple interactions
decreases expression

[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of IL6 mRNA
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased expression of IL6 mRNA

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

myeloperoxidase

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

oncostatin M receptor

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]

NCBI chr15:6,843,049...6,904,434
Ensembl chr15:6,843,058...6,904,450

G

prostaglandin-endoperoxide synthase 1

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

superoxide dismutase 1, soluble

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

signal transducer and activator of transcription 3

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

tumor necrosis factor

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased stability of and affects the expression of TNF mRNA

PMID:15060681 PMID:25432964

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

transient receptor potential cation channel, subfamily C, member 6

decreases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of TRPC6 protein

NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742

duroquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heme oxygenase 1

increases expression

duroquinone results in increased expression of HMOX1 mRNA

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

NAD(P)H dehydrogenase, quinone 1

increases expression

duroquinone results in increased expression of NQO1 mRNA

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

embelin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thymoma viral proto-oncogene 1

decreases phosphorylation

embelin results in decreased phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

autophagy related 12

multiple interactions

embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein]

NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647

G

autophagy related 5

multiple interactions

embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein]

NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287

G

BCL2-associated X protein

increases expression

embelin results in increased expression of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression

embelin results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

beclin 1, autophagy related

increases expression

embelin results in increased expression of BECN1 protein

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

caspase 3

increases cleavage
increases degradation
multiple interactions

embelin results in increased cleavage of CASP3 protein
embelin results in increased degradation of CASP3 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]

PMID:24694877 PMID:28722333

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

increases degradation
multiple interactions

embelin results in increased degradation of CASP9 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cyclin D1

decreases expression

embelin results in decreased expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cadherin 1

increases expression

embelin results in increased expression of CDH1 protein

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cyclin dependent kinase 2

decreases expression

embelin results in decreased expression of CDK2 protein

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase 6

decreases expression

embelin results in decreased expression of CDK6 protein

NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008

G

C-X-C motif chemokine ligand 15

decreases expression

embelin results in decreased expression of CXCL8 protein

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

DNA fragmentation factor, alpha subunit

increases cleavage

embelin results in increased cleavage of DFFA protein

NCBI chr 4:149,188,599...149,205,110
Ensembl chr 4:149,188,603...149,205,104

G

GLI-Kruppel family member GLI1

decreases expression

embelin results in decreased expression of GLI1 protein

NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843

G

GLI-Kruppel family member GLI2

decreases expression

embelin results in decreased expression of GLI2 protein

NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349

G

interleukin 1 beta

multiple interactions

embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions

embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

kinase insert domain protein receptor

decreases expression

embelin results in decreased expression of KDR protein

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

antigen identified by monoclonal antibody Ki 67

decreases expression

embelin results in decreased expression of MKI67 protein

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

matrix metallopeptidase 2

decreases expression

embelin results in decreased expression of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

decreases expression

embelin results in decreased expression of MMP9 protein

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

poly (ADP-ribose) polymerase family, member 1

increases cleavage
multiple interactions

embelin results in increased cleavage of PARP1 protein
3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]

PMID:24694877 PMID:28722333

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

proliferating cell nuclear antigen

decreases expression

embelin results in decreased expression of PCNA protein

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

prostaglandin-endoperoxide synthase 2

decreases expression

embelin results in decreased expression of PTGS2 protein

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

snail family zinc finger 1

decreases expression

embelin results in decreased expression of SNAI1 protein

NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734

G

snail family zinc finger 2

decreases expression

embelin results in decreased expression of SNAI2 protein

NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249

G

sequestosome 1

increases degradation

embelin results in increased degradation of SQSTM1 protein

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

tumor necrosis factor

multiple interactions

embelin inhibits the reaction [Paraquat results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 10b

increases expression

embelin results in increased expression of TNFRSF10A protein

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

vascular endothelial growth factor A

decreases expression

embelin results in decreased expression of VEGFA protein

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

X-linked inhibitor of apoptosis

decreases activity
increases degradation

embelin results in decreased activity of XIAP protein
embelin results in increased degradation of XIAP protein

PMID:16339139 PMID:28722333

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

zinc finger E-box binding homeobox 1

decreases expression

embelin results in decreased expression of ZEB1 protein

NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467

geldanamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 6030458C11 gene

increases expression

geldanamycin results in increased expression of C5ORF22 mRNA

NCBI chr15:12,806,012...12,824,767
Ensembl chr15:12,808,263...12,824,735

G

ATP-binding cassette, sub-family B member 1A

multiple interactions

geldanamycin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

increases expression

geldanamycin results in increased expression of ACAP2 mRNA

NCBI chr16:30,911,230...31,020,105
Ensembl chr16:30,911,230...31,020,063

G

actin related protein 2

increases expression

geldanamycin results in increased expression of ACTR2 mRNA

NCBI chr11:20,012,304...20,062,951
Ensembl chr11:20,012,304...20,062,913

G

AF4/FMR2 family, member 3

increases expression

geldanamycin results in increased expression of AFF3 mRNA

NCBI chr 1:38,212,936...38,704,036
Ensembl chr 1:38,216,407...38,704,036

G

AF4/FMR2 family, member 4

increases expression

geldanamycin results in increased expression of AFF4 mRNA

NCBI chr11:53,240,807...53,312,657
Ensembl chr11:53,241,660...53,312,657

G

ArfGAP with FG repeats 1

increases expression

geldanamycin results in increased expression of AGFG1 mRNA

NCBI chr 1:82,816,738...82,878,722
Ensembl chr 1:82,817,204...82,878,903

G

aryl-hydrocarbon receptor

increases localization
decreases expression
multiple interactions
increases degradation

geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form

PMID:9664232 PMID:12237327 PMID:12606767 PMID:16226227 PMID:20057149 More...

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

thymoma viral proto-oncogene 1

multiple interactions
decreases phosphorylation
decreases expression

[geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein

PMID:15781649 PMID:17293044 PMID:19167484 PMID:24211270 PMID:24450340

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

thymoma viral proto-oncogene 3

increases expression

geldanamycin results in increased expression of AKT3 mRNA

NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769

G

angiomotin-like 1

increases expression

geldanamycin results in increased expression of AMOTL1 mRNA

NCBI chr 9:14,453,262...14,574,408
Ensembl chr 9:14,453,262...14,556,352

G

angiopoietin 1

increases expression

geldanamycin results in increased expression of ANGPT1 mRNA

NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373

G

angiopoietin-like 1

decreases expression

geldanamycin results in decreased expression of ANGPTL1 mRNA

NCBI chr 1:156,666,495...156,688,648
Ensembl chr 1:156,666,132...156,688,648

G

ankyrin repeat domain 1

increases expression

geldanamycin results in increased expression of ANKRD1 mRNA

NCBI chr19:36,089,365...36,097,244
Ensembl chr19:36,089,361...36,097,499

G

adaptor-related protein complex 5, mu 1 subunit

increases expression

geldanamycin results in increased expression of AP5M1 mRNA

NCBI chr14:49,303,869...49,331,681
Ensembl chr14:49,303,554...49,331,691

G

apelin receptor early endogenous ligand

increases expression

geldanamycin results in increased expression of APELA mRNA

NCBI chr 8:65,481,069...65,489,970
Ensembl chr 8:65,481,069...65,489,988

G

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

increases expression

geldanamycin results in increased expression of APPL2 mRNA

NCBI chr10:83,435,897...83,484,741
Ensembl chr10:83,435,897...83,484,602

G

ARB2 cotranscriptional regulator A

increases expression

geldanamycin results in increased expression of ARB2A mRNA

NCBI chr13:77,856,799...78,314,359
Ensembl chr13:77,850,152...78,314,354

G

ADP-ribosylation factor interacting protein 1

increases expression

geldanamycin results in increased expression of ARFIP1 mRNA

NCBI chr 3:84,403,400...84,490,075
Ensembl chr 3:84,403,733...85,794,825
Ensembl chr 3:84,403,733...85,794,825

G

abnormal spindle microtubule assembly

increases expression

geldanamycin results in increased expression of ASPM mRNA

NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829

G

ATPase, class VI, type 11B

increases expression

geldanamycin results in increased expression of ATP11B mRNA

NCBI chr 3:35,808,104...35,910,425
Ensembl chr 3:35,808,255...35,910,425

G

ATPase, class VI, type 11C

increases expression

geldanamycin results in increased expression of ATP11C mRNA

NCBI chr X:59,268,643...59,450,041
Ensembl chr X:59,268,650...59,636,304

G

ATPase type 13A3

increases expression

geldanamycin results in increased expression of ATP13A3 mRNA

NCBI chr16:30,131,241...30,207,674
Ensembl chr16:30,131,241...30,224,793

G

ATPase type 13A5

increases expression

geldanamycin results in increased expression of ATP13A5 mRNA

NCBI chr16:29,049,242...29,208,807
Ensembl chr16:29,050,603...29,197,550

G

ATRX, chromatin remodeler

increases expression

geldanamycin results in increased expression of ATRX mRNA

NCBI chr X:104,841,221...104,972,978
Ensembl chr X:104,841,221...104,973,009

G

ataxin 7-like 3B

increases expression

geldanamycin results in increased expression of ATXN7L3B mRNA

NCBI chr10:112,761,333...112,764,931
Ensembl chr10:112,761,335...112,764,906

G

RIKEN cDNA B230219D22 gene

increases expression

geldanamycin results in increased expression of C5ORF24 mRNA

NCBI chr13:55,840,937...55,851,313
Ensembl chr13:55,840,937...55,851,313

G

B cell leukemia/lymphoma 2

multiple interactions
decreases expression

[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein; geldanamycin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
geldanamycin results in decreased expression of BCL2 protein

PMID:15781649 PMID:28673683 PMID:37586545

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

decreases response to substance
multiple interactions

BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BCL6 interacting corepressor

increases expression

geldanamycin results in increased expression of BCOR mRNA

NCBI chr X:11,902,976...12,026,769
Ensembl chr X:11,902,979...12,026,594

G

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

increases expression

geldanamycin results in increased expression of BDP1 mRNA

NCBI chr13:100,154,502...100,244,524
Ensembl chr13:100,154,502...100,240,578

G

baculoviral IAP repeat-containing 2

multiple interactions

[geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

bridge-like lipid transfer protein family member 2

increases expression

geldanamycin results in increased expression of BLTP2 mRNA

NCBI chr11:78,152,476...78,181,451
Ensembl chr11:78,152,578...78,181,449

G

biorientation of chromosomes in cell division 1-like

increases expression

geldanamycin results in increased expression of BOD1L1 mRNA

NCBI chr 5:41,944,881...42,001,695
Ensembl chr 5:41,944,881...42,001,658

G

calcium binding protein 39

increases expression

geldanamycin results in increased expression of CAB39 mRNA

NCBI chr 1:85,707,796...85,779,298
Ensembl chr 1:85,721,162...85,779,297

G

caldesmon 1

increases expression

geldanamycin results in increased expression of CALD1 mRNA

NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408

G

calcium/calmodulin dependent serine protein kinase

increases expression

geldanamycin results in increased expression of CASK mRNA

NCBI chr X:13,383,319...13,713,020
Ensembl chr X:13,383,319...13,717,606

G

caspase 3

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]

PMID:12115584 PMID:12530016 PMID:14576064 PMID:24998639

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein]

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 9

multiple interactions

geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

Casitas B-lineage lymphoma

increases expression

geldanamycin results in increased expression of CBL mRNA

NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346

G

coiled-coil domain containing 186

increases expression

geldanamycin results in increased expression of CCDC186 mRNA

NCBI chr19:56,775,917...56,810,631
Ensembl chr19:56,775,913...56,810,622

G

cyclin D1

multiple interactions
decreases expression

[geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein

PMID:15781649 PMID:17959518 PMID:24211270

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin D2

increases expression

geldanamycin results in increased expression of CCND2 mRNA

NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156

G

cyclin E2

increases expression

geldanamycin results in increased expression of CCNE2 mRNA

NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779

G

cyclin K

increases expression

geldanamycin results in increased expression of CCNK mRNA

NCBI chr12:108,145,543...108,170,252
Ensembl chr12:108,145,838...108,169,618

G

cell division cycle 27

increases expression

geldanamycin results in increased expression of CDC27 mRNA

NCBI chr11:104,393,350...104,441,371
Ensembl chr11:104,393,571...104,441,446

G

cell division cycle 37

multiple interactions

geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein]

NCBI chr 9:21,050,727...21,061,230
Ensembl chr 9:21,044,518...21,061,278

G

cell division cycle associated 2

increases expression

geldanamycin results in increased expression of CDCA2 mRNA

NCBI chr14:67,910,629...67,953,290
Ensembl chr14:67,913,780...67,953,290

G

cadherin 1

multiple interactions
increases expression

geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein]

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 4

increases expression

geldanamycin results in increased expression of CDH4 mRNA

NCBI chr 2:179,084,228...179,541,166
Ensembl chr 2:179,084,224...179,541,166

G

cyclin dependent kinase 13

increases expression

geldanamycin results in increased expression of CDK13 mRNA

NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682

G

cyclin dependent kinase 14

increases expression

geldanamycin results in increased expression of CDK14 mRNA

NCBI chr 5:4,853,384...5,430,650
Ensembl chr 5:4,853,391...5,470,312

G

cyclin dependent kinase 4

decreases expression

geldanamycin results in decreased expression of CDK4 protein

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase 6

increases expression

geldanamycin results in increased expression of CDK6 mRNA

NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008

G

CCAAT/enhancer binding protein beta

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

centromere protein J

increases expression

geldanamycin results in increased expression of CENPJ mRNA

NCBI chr14:56,764,218...56,812,950
Ensembl chr14:56,764,218...56,812,882

G

centrosomal protein 89

increases expression

geldanamycin results in increased expression of CEP89 mRNA

NCBI chr 7:35,096,425...35,139,255
Ensembl chr 7:35,096,460...35,138,114

G

centrosomal protein 95

increases expression

geldanamycin results in increased expression of CEP95 mRNA

NCBI chr11:106,679,466...106,709,687
Ensembl chr11:106,680,078...106,710,756

G

ceramide synthase 6

increases expression

geldanamycin results in increased expression of CERS6 mRNA

NCBI chr 2:68,691,489...68,944,628
Ensembl chr 2:68,691,785...68,944,626

G

cystic fibrosis transmembrane conductance regulator

multiple interactions

geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

conserved helix-loop-helix ubiquitous kinase

increases degradation

geldanamycin results in increased degradation of CHUK protein

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

CAP-GLY domain containing linker protein 1

increases expression

geldanamycin results in increased expression of CLIP1 mRNA

NCBI chr 5:123,715,857...123,822,527
Ensembl chr 5:123,715,858...123,822,681

G

CDC like kinase 4

increases expression

geldanamycin results in increased expression of CLK4 mRNA

NCBI chr11:51,153,941...51,172,597
Ensembl chr11:51,152,557...51,172,593

G

collagen, type XII, alpha 1

increases expression

geldanamycin results in increased expression of COL12A1 mRNA

NCBI chr 9:79,506,269...79,628,423
Ensembl chr 9:79,506,273...79,626,113

G

collagen, type XXV, alpha 1

increases expression

geldanamycin results in increased expression of COL25A1 mRNA

NCBI chr 3:129,973,992...130,393,533
Ensembl chr 3:129,925,150...130,393,526

G

collagen, type VIII, alpha 1

increases expression

geldanamycin results in increased expression of COL8A1 mRNA

NCBI chr16:57,444,619...57,575,100
Ensembl chr16:57,444,621...57,575,100

G

copine III

increases expression

geldanamycin results in increased expression of CPNE3 mRNA

NCBI chr 4:19,519,252...19,570,108
Ensembl chr 4:19,519,254...19,570,108

G

calcitonin gene-related peptide-receptor component protein

increases expression

geldanamycin results in increased expression of CRCP mRNA

NCBI chr 5:130,058,147...130,089,628
Ensembl chr 5:130,058,131...130,089,630

G

c-src tyrosine kinase

multiple interactions
decreases activity

geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein

NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914

G

casein kinase 2, alpha 1 polypeptide

increases expression

geldanamycin results in increased expression of CSNK2A1 mRNA

NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772

G

CTD small phosphatase like 2

increases expression

geldanamycin results in increased expression of CTDSPL2 mRNA

NCBI chr 2:121,785,879...121,845,807
Ensembl chr 2:121,786,482...121,844,123

G

catenin alpha 1

increases expression

geldanamycin results in increased expression of CTNNA1 mRNA

NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832

G

catenin beta 1

multiple interactions

geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cullin 5

increases expression

geldanamycin results in increased expression of CUL5 mRNA

NCBI chr 9:53,525,881...53,578,807
Ensembl chr 9:53,525,882...53,581,314

G

C-X-C motif chemokine ligand 15

multiple interactions

geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

geldanamycin results in increased expression of CYP17A1 mRNA

NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:12237327 PMID:20057149

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

discoidin domain receptor family, member 2

increases expression

geldanamycin results in increased expression of DDR2 mRNA

NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331

G

DEAD box helicase 17

increases expression

geldanamycin results in increased expression of DDX17 mRNA

NCBI chr15:79,411,897...79,430,976
Ensembl chr15:79,411,937...79,430,942

G

DEAD box helicase 3, X-linked

increases expression
increases degradation

geldanamycin results in increased expression of DDX3X mRNA
geldanamycin results in increased degradation of DDX3X protein

PMID:26705709 PMID:30821613

NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291

G

DEAD box helicase 42

increases expression

geldanamycin results in increased expression of DDX42 mRNA

NCBI chr11:106,107,715...106,139,966
Ensembl chr11:106,107,752...106,139,965

G

DEAD-box helicase 6

increases expression

geldanamycin results in increased expression of DDX6 mRNA

NCBI chr 9:44,514,113...44,552,028
Ensembl chr 9:44,516,189...44,552,028

G

DExH-box helicase 9

increases expression

geldanamycin results in increased expression of DHX9 mRNA

NCBI chr 1:153,331,506...153,363,464
Ensembl chr 1:153,331,504...153,363,406

G

disco interacting protein 2 homolog A

increases expression

geldanamycin results in increased expression of DIP2A mRNA

NCBI chr10:76,098,581...76,181,194
Ensembl chr10:76,095,263...76,181,125

G

discs large MAGUK scaffold protein 1

increases expression

geldanamycin results in increased expression of DLG1 mRNA

NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947

G

dystrophin, muscular dystrophy

increases expression

geldanamycin results in increased expression of DMD mRNA

NCBI chr X:81,858,244...84,248,656
Ensembl chr X:81,992,476...84,249,747

G

DnaJ heat shock protein family (Hsp40) member C13

increases expression

geldanamycin results in increased expression of DNAJC13 mRNA

NCBI chr 9:104,028,796...104,140,807
Ensembl chr 9:104,028,481...104,140,129

G

dystonin

increases expression

geldanamycin results in increased expression of DST mRNA

NCBI chr 1:33,946,969...34,347,743
Ensembl chr 1:33,947,306...34,347,742

G

E2F transcription factor 3

increases expression

geldanamycin results in increased expression of E2F3 mRNA

NCBI chr13:30,090,558...30,171,172
Ensembl chr13:30,090,558...30,170,046

G

EGF-like repeats and discoidin I-like domains 3

increases expression

geldanamycin results in increased expression of EDIL3 mRNA

NCBI chr13:88,969,591...89,471,344
Ensembl chr13:88,969,591...89,471,342

G

endothelin 1

increases expression

geldanamycin results in increased expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

early endosome antigen 1

increases expression

geldanamycin results in increased expression of EEA1 mRNA

NCBI chr10:95,776,525...95,881,380
Ensembl chr10:95,776,512...95,881,380

G

epidermal growth factor

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]

PMID:9605431 PMID:9664232

NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965

G

epidermal growth factor receptor

multiple interactions
decreases expression

geldanamycin inhibits the reaction [TNF protein results in increased expression of EGFR mRNA]; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein

PMID:9605431 PMID:9664232 PMID:20007406 PMID:37586545

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

EH domain binding protein 1

increases expression

geldanamycin results in increased expression of EHBP1 mRNA

NCBI chr11:21,955,825...22,237,086
Ensembl chr11:21,955,828...22,292,292

G

euchromatic histone methyltransferase 1

increases expression

geldanamycin results in increased expression of EHMT1 mRNA

NCBI chr 2:24,680,781...24,809,658
Ensembl chr 2:24,679,940...24,809,626

G

eukaryotic translation initiation factor 4A1

increases degradation

geldanamycin results in increased degradation of EIF4A1 protein

NCBI chr11:69,557,762...69,563,249
Ensembl chr11:69,557,762...69,563,249

G

elongation factor for RNA polymerase II 2

increases expression

geldanamycin results in increased expression of ELL2 mRNA

NCBI chr13:75,855,603...75,920,480
Ensembl chr13:75,854,876...75,920,483

G

erythrocyte membrane protein band 4.1 like 5

increases expression

geldanamycin results in increased expression of EPB41L5 mRNA

NCBI chr 1:119,472,762...119,576,826
Ensembl chr 1:119,472,767...119,576,730

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

geldanamycin results in increased expression of EPRS1 mRNA

NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557

G

erb-b2 receptor tyrosine kinase 2

increases degradation
multiple interactions
decreases expression

geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein

PMID:8617772 PMID:11071886 PMID:17959518 PMID:18655187 PMID:24450340

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2

increases expression

geldanamycin results in increased expression of ERCC6L2 mRNA

NCBI chr13:63,958,793...64,048,116
Ensembl chr13:63,963,054...64,048,116

G

establishment of sister chromatid cohesion N-acetyltransferase 1

increases expression

geldanamycin results in increased expression of ESCO1 mRNA

NCBI chr18:10,566,507...10,610,863
Ensembl chr18:10,566,507...10,610,352

G

establishment of sister chromatid cohesion N-acetyltransferase 2

increases expression

geldanamycin results in increased expression of ESCO2 mRNA

NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443

G

estrogen receptor 1 (alpha)

multiple interactions
decreases expression
decreases stability
increases degradation

geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein

PMID:11448926 PMID:16037132 PMID:24211270

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

E26 avian leukemia oncogene 1, 5' domain

increases expression

geldanamycin results in increased expression of ETS1 mRNA

NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116

G

ecotropic viral integration site 5

increases expression

geldanamycin results in increased expression of EVI5 mRNA

NCBI chr 5:107,892,661...108,022,973
Ensembl chr 5:107,892,661...108,022,973

G

Fanconi anemia, complementation group B

increases expression

geldanamycin results in increased expression of FANCB mRNA

NCBI chr X:163,763,678...163,780,266
Ensembl chr X:163,763,588...163,780,268

G

Fanconi anemia, complementation group M

increases expression

geldanamycin results in increased expression of FANCM mRNA

NCBI chr12:65,120,884...65,178,616
Ensembl chr12:65,122,377...65,178,832

G

fibrillin 1

increases expression

geldanamycin results in increased expression of FBN1 mRNA

NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913

G

fibroblast growth factor 7

multiple interactions

geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein]

NCBI chr 2:125,876,578...125,933,105
Ensembl chr 2:125,876,578...125,933,105

G

FMS-like tyrosine kinase 1

increases expression

geldanamycin results in increased expression of FLT1 mRNA

NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821

G

fibronectin 1

increases expression

geldanamycin results in increased expression of FN1 mRNA

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

FRY like transcription coactivator

increases expression

geldanamycin results in increased expression of FRYL mRNA

NCBI chr 5:73,177,534...73,414,042
Ensembl chr 5:73,177,330...73,413,962

G

G3BP stress granule assembly factor 1

increases expression

geldanamycin results in increased expression of G3BP1 mRNA

NCBI chr11:55,360,521...55,391,722
Ensembl chr11:55,360,511...55,395,664

G

polypeptide N-acetylgalactosaminyltransferase 5

increases expression

geldanamycin results in increased expression of GALNT5 mRNA

NCBI chr 2:57,887,832...57,931,039
Ensembl chr 2:57,887,896...57,935,872

G

glutaminase

increases expression

geldanamycin results in increased expression of GLS mRNA

NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391

G

guanine nucleotide binding protein (G protein), gamma 12

increases expression

geldanamycin results in increased expression of GNG12 mRNA

NCBI chr 6:66,873,381...66,998,345
Ensembl chr 6:66,873,381...66,998,334

G

golgi integral membrane protein 4

increases expression

geldanamycin results in increased expression of GOLIM4 mRNA

NCBI chr 3:75,783,490...75,864,256
Ensembl chr 3:75,782,391...75,864,256

G

glutamate receptor, ionotropic, AMPA3 (alpha 3)

increases expression

geldanamycin results in increased expression of GRIA3 mRNA

NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478

G

general transcription factor II A, 1

increases expression

geldanamycin results in increased expression of GTF2A1 mRNA

NCBI chr12:91,522,036...91,559,102
Ensembl chr12:91,522,036...91,557,261

G

H1.3 linker histone, cluster member

increases expression

geldanamycin results in increased expression of H1-3 mRNA

NCBI chr13:23,739,206...23,739,981
Ensembl chr13:23,737,436...23,744,860

G

3-hydroxyacyl-CoA dehydratase 2

increases expression

geldanamycin results in increased expression of HACD2 mRNA

NCBI chr16:34,842,791...34,929,560
Ensembl chr16:34,842,798...34,929,547

G

hyperpolarization activated cyclic nucleotide gated potassium channel 1

increases expression

geldanamycin results in increased expression of HCN1 mRNA

NCBI chr13:117,738,856...118,117,564
Ensembl chr13:117,738,856...118,123,954

G

HEAT repeat containing 1

increases expression

geldanamycin results in increased expression of HEATR1 mRNA

NCBI chr13:12,410,256...12,453,774
Ensembl chr13:12,409,908...12,455,170

G

HECT domain E3 ubiquitin protein ligase 1

increases expression

geldanamycin results in increased expression of HECTD1 mRNA

NCBI chr12:51,790,504...51,876,540
Ensembl chr12:51,790,505...51,876,319

G

hypoxia inducible factor 1, alpha subunit

multiple interactions
decreases expression
increases degradation

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of HIF1A mRNA]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein

PMID:11980636 PMID:12811834 PMID:14726529 PMID:15319539 PMID:16432534 More...

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

multiple interactions

geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein]

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hydroxyprostaglandin dehydrogenase 15 (NAD)

multiple interactions

geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]

NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078

G

heat shock factor 1

multiple interactions

geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein

PMID:10632574 PMID:25645596

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 90, alpha (cytosolic), class A member 1

affects binding
multiple interactions

geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]

PMID:12775586 PMID:17223712 PMID:18655187 PMID:21749116

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 90 alpha (cytosolic), class B member 1

affects binding
increases expression

geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA

PMID:21749116 PMID:26705709

NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197

G

heat shock protein 90, beta (Grp94), member 1

affects binding
multiple interactions

geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]

NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373

G

heat shock protein 1A

increases expression
multiple interactions

geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins

PMID:11448926 PMID:19723345 PMID:25477506

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 4

increases expression
multiple interactions

geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin

PMID:16311509 PMID:26705709

NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284

G

heat shock protein 5

multiple interactions
increases expression
affects expression

Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein

PMID:14576064 PMID:15141013

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 1 (chaperonin)

increases expression

geldanamycin results in increased expression of HSPD1 mRNA

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

huntingtin

multiple interactions

geldanamycin inhibits the reaction [HTT protein binds to HTT protein]

NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878

G

hyccin PI4KA lipid kinase complex subunit 1

increases expression

geldanamycin results in increased expression of HYCC1 mRNA

NCBI chr 5:24,120,274...24,235,694
Ensembl chr 5:24,120,274...24,235,688

G

interactor of little elongation complex ELL subunit 2

increases expression

geldanamycin results in increased expression of ICE2 mRNA

NCBI chr 9:69,305,185...69,340,360
Ensembl chr 9:69,305,188...69,340,404

G

interleukin 1 beta

multiple interactions

geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]

PMID:12571865 PMID:15808840 PMID:37586545

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 24

multiple interactions

IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein]

NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191

G

interleukin 6

multiple interactions

geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 signal transducer

increases expression

geldanamycin results in increased expression of IL6ST mRNA

NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620

G

inhibin beta-A

increases expression

geldanamycin results in increased expression of INHBA mRNA

NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206

G

inositol polyphosphate-5-phosphatase A

increases expression

geldanamycin results in increased expression of INPP5A mRNA

NCBI chr 7:138,969,025...139,159,568
Ensembl chr 7:138,969,025...139,159,568

G

importin 8

increases expression

geldanamycin results in increased expression of IPO8 mRNA

NCBI chr 6:148,672,181...148,732,977
Ensembl chr 6:148,672,181...148,732,965

G

IQ motif containing GTPase activating protein 1

increases expression

geldanamycin results in increased expression of IQGAP1 mRNA

NCBI chr 7:80,361,331...80,453,288
Ensembl chr 7:80,361,331...80,475,722

G

integrin alpha 1

increases expression

geldanamycin results in increased expression of ITGA1 mRNA

NCBI chr13:115,094,615...115,238,500
Ensembl chr13:115,089,632...115,238,500

G

integrin beta 3

increases expression

geldanamycin results in increased expression of ITGB3 mRNA

NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302

G

ITPR interacting domain containing 2

increases expression

geldanamycin results in increased expression of SSFA2 mRNA

NCBI chr 2:79,419,207...79,503,310
Ensembl chr 2:79,465,696...79,503,310

G

jumonji domain containing 1C

increases expression

geldanamycin results in increased expression of JMJD1C mRNA

NCBI chr10:66,932,189...67,092,105
Ensembl chr10:66,931,904...67,092,105

G

K(lysine) acetyltransferase 6A

increases expression

geldanamycin results in increased expression of KAT6A mRNA

NCBI chr 8:23,349,458...23,433,275
Ensembl chr 8:23,349,551...23,433,275

G

kelch repeat and BTB (POZ) domain containing 2

increases expression

geldanamycin results in increased expression of KBTBD2 mRNA

NCBI chr 6:56,754,510...56,774,798
Ensembl chr 6:56,754,509...56,774,798

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

affects localization
decreases activity
increases degradation
multiple interactions
decreases expression

geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form

PMID:12775586 PMID:24052561

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

lysine (K)-specific demethylase 6A

increases expression

geldanamycin results in increased expression of KDM6A mRNA

NCBI chr X:18,027,101...18,147,061
Ensembl chr X:18,028,814...18,146,175

G

kirre like nephrin family adhesion molecule 1

increases expression

geldanamycin results in increased expression of KIRREL1 mRNA

NCBI chr 3:86,985,900...87,082,084
Ensembl chr 3:86,985,900...87,082,054

G

Kruppel-like transcription factor 12

increases expression

geldanamycin results in increased expression of KLF12 mRNA

NCBI chr14:100,103,617...100,719,681
Ensembl chr14:100,108,068...100,522,115

G

kelch-like 24

increases expression

geldanamycin results in increased expression of KLHL24 mRNA

NCBI chr16:19,916,286...19,947,976
Ensembl chr16:19,916,292...19,947,971

G

lysine (K)-specific methyltransferase 2A

increases expression

geldanamycin results in increased expression of KMT2A mRNA

NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594

G

kinetochore scaffold 1

increases expression

geldanamycin results in increased expression of KNL1 mRNA

NCBI chr 2:118,877,600...118,940,978
Ensembl chr 2:118,877,600...118,935,982

G

laminin, alpha 4

increases expression

geldanamycin results in increased expression of LAMA4 mRNA

NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184

G

La ribonucleoprotein 1B

increases expression

geldanamycin results in increased expression of LARP1B mRNA

NCBI chr 3:40,904,198...40,994,642
Ensembl chr 3:40,904,263...40,994,669

G

La ribonucleoprotein 4

increases expression

geldanamycin results in increased expression of LARP4 mRNA

NCBI chr15:99,867,946...99,914,239
Ensembl chr15:99,867,946...99,914,239

G

leucyl-tRNA synthetase 1

increases expression

geldanamycin results in increased expression of LARS1 mRNA

NCBI chr18:42,335,363...42,395,302
Ensembl chr18:42,335,363...42,395,259

G

LIM domain and actin binding 1

increases expression

geldanamycin results in increased expression of LIMA1 mRNA

NCBI chr15:99,676,351...99,773,292
Ensembl chr15:99,676,351...99,773,337

G

lin-7 homolog A, crumbs cell polarity complex component

increases expression

geldanamycin results in increased expression of LIN7A mRNA

NCBI chr10:107,107,410...107,261,007
Ensembl chr10:107,107,547...107,257,335

G

lectin, mannose-binding, 1

increases expression

geldanamycin results in increased expression of LMAN1 mRNA

NCBI chr18:66,113,810...66,135,706
Ensembl chr18:66,113,809...66,155,651

G

LIM domain only 7

increases expression

geldanamycin results in increased expression of LMO7 mRNA

NCBI chr14:101,967,353...102,172,144
Ensembl chr14:101,967,393...102,172,146

G

LIM domain containing preferred translocation partner in lipoma

increases expression

geldanamycin results in increased expression of LPP mRNA

NCBI chr16:24,212,100...24,811,328
Ensembl chr16:24,212,257...24,811,328

G

leucine rich repeat containing 58

increases expression

geldanamycin results in increased expression of LRRC58 mRNA

NCBI chr16:37,688,762...37,709,219
Ensembl chr16:37,688,751...37,709,220

G

LSM family member 14B

increases expression

geldanamycin results in increased expression of LSM14B mRNA

NCBI chr 2:179,666,770...179,677,254
Ensembl chr 2:179,666,780...179,677,258

G

metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)

increases expression

geldanamycin results in increased expression of MALAT1 mRNA

NCBI chr19:5,845,718...5,852,700
Ensembl chr19:5,845,717...5,852,706

G

mannosidase, alpha, class 1A, member 2

increases expression

geldanamycin results in increased expression of MAN1A2 mRNA

NCBI chr 3:100,469,519...100,592,789
Ensembl chr 3:100,469,524...100,592,819

G

microtubule-associated protein 1B

increases expression

geldanamycin results in increased expression of MAP1B mRNA

NCBI chr13:99,557,972...99,653,110
Ensembl chr13:99,557,954...99,653,048

G

mitogen-activated protein kinase kinase 1

multiple interactions
decreases phosphorylation

geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein

PMID:8816498 PMID:19167484

NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913

G

mitogen-activated protein kinase kinase 2

decreases phosphorylation

geldanamycin results in decreased phosphorylation of MAP2K2 protein

NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809

G

mitogen-activated protein kinase kinase kinase 1

increases expression

geldanamycin results in increased expression of MAP3K1 mRNA

NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527

G

mitogen-activated protein kinase kinase kinase 5

increases expression

geldanamycin results in increased expression of MAP3K5 mRNA

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

mitogen-activated protein kinase kinase kinase kinase 5

increases expression

geldanamycin results in increased expression of MAP4K5 mRNA

NCBI chr12:69,850,531...69,939,937
Ensembl chr12:69,850,524...69,939,974

G

mitogen-activated protein kinase 1

multiple interactions
decreases expression
decreases phosphorylation

geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 PMID:30166341

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation

geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

MAP kinase-activated protein kinase 2

increases expression

geldanamycin results in increased expression of MAPKAPK2 mRNA

NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563

G

matrin 3

increases expression

geldanamycin results in increased expression of MATR3 mRNA

NCBI chr18:35,686,462...35,724,526
Ensembl chr18:35,695,191...35,726,888

G

muscleblind like splicing regulator 1

increases expression

geldanamycin results in increased expression of MBNL1 mRNA

NCBI chr 3:60,380,209...60,537,171
Ensembl chr 3:60,380,251...60,537,171

G

muscleblind like splicing factor 2

increases expression

geldanamycin results in increased expression of MBNL2 mRNA

NCBI chr14:120,513,077...120,669,110
Ensembl chr14:120,513,081...120,669,109

G

mbt domain containing 1

increases expression

geldanamycin results in increased expression of MBTD1 mRNA

NCBI chr11:93,776,635...93,837,815
Ensembl chr11:93,776,678...93,837,811

G

melanoma cell adhesion molecule

increases expression

geldanamycin results in increased expression of MCAM mRNA

NCBI chr 9:44,045,958...44,054,024
Ensembl chr 9:44,045,766...44,054,024

G

minichromosome maintenance complex component 4

increases expression

geldanamycin results in increased expression of MCM4 mRNA

NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264

G

MyoD family inhibitor domain containing

increases expression

geldanamycin results in increased expression of MDFIC mRNA

NCBI chr 6:15,720,660...15,802,168
Ensembl chr 6:15,720,660...15,802,168

G

transformed mouse 3T3 cell double minute 2

increases expression

geldanamycin results in increased expression of MDM2 mRNA

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

mediator complex subunit 13

increases expression

geldanamycin results in increased expression of MED13 mRNA

NCBI chr11:86,157,859...86,248,422
Ensembl chr11:86,157,859...86,248,428

G

mediator complex subunit 7

increases expression

geldanamycin results in increased expression of MED7 mRNA

NCBI chr11:46,327,742...46,333,548
Ensembl chr11:46,327,752...46,333,548

G

met proto-oncogene

increases expression

geldanamycin results in increased expression of MET mRNA

NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979

G

methyltransferase 16, N6-methyladenosine

increases expression

geldanamycin results in increased expression of METTL16 mRNA

NCBI chr11:74,661,658...74,716,649
Ensembl chr11:74,661,656...74,719,351

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

geldanamycin results in increased expression of and results in increased activity of MGMT protein

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

G

MEIR1 treanscription regulator

increases expression

geldanamycin results in increased expression of MIER1 mRNA

NCBI chr 4:102,971,521...103,022,951
Ensembl chr 4:102,971,587...103,022,951

G

microRNA 21a

increases expression

geldanamycin results in increased expression of MIR21 mRNA

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

MIS18 binding protein 1

increases expression

geldanamycin results in increased expression of MIS18BP1 mRNA

NCBI chr12:65,179,508...65,219,363
Ensembl chr12:65,179,508...65,219,378

G

matrix metallopeptidase 16

increases expression

geldanamycin results in increased expression of MMP16 mRNA

NCBI chr 4:17,853,072...18,117,479
Ensembl chr 4:17,852,893...18,119,145

G

matrix metallopeptidase 1b (interstitial collagenase)

decreases expression
multiple interactions

geldanamycin results in decreased expression of MMP1 mRNA
[geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA

PMID:12724357 PMID:26705709

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

NADH dehydrogenase 6, mitochondrial

increases expression

geldanamycin results in increased expression of ND6 mRNA

NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070

G

myosin VA

increases expression

geldanamycin results in increased expression of MYO5A mRNA

NCBI chr 9:74,975,183...75,130,970
Ensembl chr 9:74,978,297...75,130,970

G

myocardin

increases expression

geldanamycin results in increased expression of MYOCD mRNA

NCBI chr11:65,064,434...65,160,821
Ensembl chr11:65,067,387...65,160,815

G

mitotic spindle organizing protein 1

increases expression

geldanamycin results in increased expression of MZT1 mRNA

NCBI chr14:99,271,980...99,283,898
Ensembl chr14:99,271,980...99,283,570

G

nuclear autoantigenic sperm protein (histone-binding)

increases expression

geldanamycin results in increased expression of NASP mRNA

NCBI chr 4:116,458,249...116,488,894
Ensembl chr 4:116,458,249...116,485,138

G

neuroblastoma amplified sequence

increases expression

geldanamycin results in increased expression of NBAS mRNA

NCBI chr12:13,319,102...13,687,381
Ensembl chr12:13,319,134...13,633,812

G

nuclear receptor coactivator 2

increases expression

geldanamycin results in increased expression of NCOA2 mRNA

NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307

G

neural precursor cell expressed, developmentally down-regulated gene 9

increases expression

geldanamycin results in increased expression of NEDD9 mRNA

NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838

G

nestin

increases expression

geldanamycin results in increased expression of NES mRNA

NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758

G

neurofibromin 1

increases expression

geldanamycin results in increased expression of NF1 mRNA

NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438

G

neurofibromin 2

increases expression

geldanamycin results in increased expression of NF2 mRNA

NCBI chr11:4,715,845...4,799,544
Ensembl chr11:4,715,845...4,799,536

G

nuclear factor of activated T cells 5

increases expression

geldanamycin results in increased expression of NFAT5 mRNA

NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149

G

NIPBL cohesin loading factor

increases expression

geldanamycin results in increased expression of NIPBL mRNA

NCBI chr15:8,319,308...8,494,799
Ensembl chr15:8,320,101...8,473,947

G

natural killer tumor recognition sequence

increases expression

geldanamycin results in increased expression of NKTR mRNA

NCBI chr 9:121,542,244...121,585,908
Ensembl chr 9:121,548,235...121,585,909

G

nitric oxide synthase 2, inducible

multiple interactions
decreases expression

geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA]
geldanamycin inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]

PMID:11835313 PMID:15583003 PMID:37586545

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

natriuretic peptide receptor 3

increases expression

geldanamycin results in increased expression of NPR3 mRNA

NCBI chr15:11,839,982...11,907,287
Ensembl chr15:11,839,982...11,907,373

G

NAD(P)H dehydrogenase, quinone 1

increases reduction

NQO1 protein results in increased reduction of geldanamycin

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 2, group C, member 2

increases expression

geldanamycin results in increased expression of NR2C2 mRNA

NCBI chr 6:92,068,426...92,150,039
Ensembl chr 6:92,068,371...92,151,275

G

Nik related kinase

increases expression

geldanamycin results in increased expression of NRK mRNA

NCBI chr X:137,814,980...137,911,281
Ensembl chr X:137,815,179...137,911,281

G

oxysterol binding protein-like 8

increases expression

geldanamycin results in increased expression of OSBPL8 mRNA

NCBI chr10:111,000,663...111,133,110
Ensembl chr10:111,000,613...111,133,110

G

OTU domain containing 4

increases expression

geldanamycin results in increased expression of OTUD4 mRNA

NCBI chr 8:80,366,305...80,404,384
Ensembl chr 8:80,366,247...80,404,353

G

oxytocin receptor

increases expression

geldanamycin results in increased expression of OXTR mRNA

NCBI chr 6:112,450,646...112,467,800
Ensembl chr 6:112,450,644...112,466,904

G

purinergic receptor P2X, ligand-gated ion channel, 1

multiple interactions

geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]

NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026

G

pregnancy-associated plasma protein A

increases expression

geldanamycin results in increased expression of PAPPA mRNA

NCBI chr 4:65,041,993...65,276,776
Ensembl chr 4:65,042,411...65,275,746

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases degradation

geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein]

PMID:16311509 PMID:17293044

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

poly(rC) binding protein 2

increases expression

geldanamycin results in increased expression of PCBP2 mRNA

NCBI chr15:102,378,974...102,408,503
Ensembl chr15:102,378,974...102,408,496

G

pericentriolar material 1

increases expression

geldanamycin results in increased expression of PCM1 mRNA

NCBI chr 8:41,692,521...41,787,125
Ensembl chr 8:41,692,789...41,785,381

G

phosphodiesterase 4D interacting protein (myomegalin)

increases expression

geldanamycin results in increased expression of PDE4DIP mRNA

NCBI chr 3:97,597,144...97,796,023
Ensembl chr 3:97,597,140...97,796,023

G

platelet derived growth factor, alpha

increases expression

geldanamycin results in increased expression of PDGFA mRNA

NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125

G

paternally expressed 10

increases expression

geldanamycin results in increased expression of PEG10 mRNA

NCBI chr 6:4,747,306...4,760,517
Ensembl chr 6:4,747,306...4,760,517

G

progesterone receptor

decreases expression

geldanamycin results in decreased expression of PGR protein

NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612

G

phosphatase and actin regulator 2

increases expression

geldanamycin results in increased expression of PHACTR2 mRNA

NCBI chr10:13,083,461...13,350,266
Ensembl chr10:13,083,461...13,350,156

G

pleckstrin homology like domain, family B, member 2

increases expression

geldanamycin results in increased expression of PHLDB2 mRNA

NCBI chr16:45,566,593...45,773,961
Ensembl chr16:45,566,606...45,773,961

G

putative homeodomain transcription factor 2

increases expression

geldanamycin results in increased expression of PHTF2 mRNA

NCBI chr 5:20,963,662...21,087,122
Ensembl chr 5:20,963,661...21,087,122

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

increases expression

geldanamycin results in increased expression of PIK3CA mRNA

NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

geldanamycin results in increased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

plasminogen activator, urokinase

multiple interactions

[geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

phospholipid phosphatase related 4

increases expression

geldanamycin results in increased expression of PLPPR4 mRNA

NCBI chr 3:117,112,794...117,154,525
Ensembl chr 3:117,112,788...117,154,525

G

plexin A2

increases expression

geldanamycin results in increased expression of PLXNA2 mRNA

NCBI chr 1:194,302,020...194,499,177
Ensembl chr 1:194,300,526...194,499,177

G

polymerase (RNA) II (DNA directed) polypeptide B

decreases expression

geldanamycin results in decreased expression of POLR2B mRNA

NCBI chr 5:77,458,331...77,497,175
Ensembl chr 5:77,457,994...77,497,171

G

protein phosphatase 1K (PP2C domain containing)

increases expression

geldanamycin results in increased expression of PPM1K mRNA

NCBI chr 6:57,483,487...57,512,537
Ensembl chr 6:57,483,487...57,512,453

G

protein kinase, AMP-activated, alpha 1 catalytic subunit

multiple interactions

Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein

NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380

G

protein kinase, AMP-activated, alpha 2 catalytic subunit

multiple interactions

Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA2 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA2 protein

NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087

G

protein kinase, cGMP-dependent, type I

increases expression

geldanamycin results in increased expression of PRKG1 mRNA

NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433

G

protein arginine N-methyltransferase 2

increases expression

geldanamycin results in increased expression of PRMT2 mRNA

NCBI chr10:76,043,060...76,073,699
Ensembl chr10:76,043,056...76,073,699

G

pre-mRNA splicing factor 6

increases expression

geldanamycin results in increased expression of PRPF6 mRNA

NCBI chr 2:181,243,112...181,297,454
Ensembl chr 2:181,233,661...181,297,453

G

proline rich 14-like

increases expression

geldanamycin results in increased expression of PRR14L mRNA

NCBI chr 5:32,946,551...33,011,679
Ensembl chr 5:32,947,164...33,011,600

G

proline-rich coiled-coil 2C

increases expression

geldanamycin results in increased expression of PRRC2C mRNA

NCBI chr 1:162,499,354...162,568,125
Ensembl chr 1:162,498,294...162,568,125

G

proteasome (prosome, macropain) activator subunit 4

increases expression

geldanamycin results in increased expression of PSME4 mRNA

NCBI chr11:30,721,753...30,831,150
Ensembl chr11:30,721,726...30,830,361

G

protein prenyltransferase alpha subunit repeat containing 1

increases expression

geldanamycin results in increased expression of PTAR1 mRNA

NCBI chr19:23,664,728...23,710,249
Ensembl chr19:23,664,793...23,709,032

G

polypyrimidine tract binding protein 3

increases expression

geldanamycin results in increased expression of PTBP3 mRNA

NCBI chr 4:59,471,868...59,549,288
Ensembl chr 4:59,471,868...59,549,364

G

prostaglandin-endoperoxide synthase 1

decreases expression

geldanamycin results in decreased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

parathyroid hormone-like peptide

multiple interactions

[geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA

NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681

G

PTK2 protein tyrosine kinase 2

increases degradation
decreases phosphorylation

geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein

PMID:9973544 PMID:12811834

NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129

G

protein tyrosine phosphatase, non-receptor type 11

increases expression

geldanamycin results in increased expression of PTPN11 mRNA

NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460

G

protein tyrosine phosphatase, non-receptor type 12

increases expression

geldanamycin results in increased expression of PTPN12 mRNA

NCBI chr 5:21,191,643...21,261,009
Ensembl chr 5:21,191,643...21,260,909

G

protein tyrosine phosphatase receptor type A

increases expression

geldanamycin results in increased expression of PTPRA mRNA

NCBI chr 2:130,292,198...130,396,220
Ensembl chr 2:130,292,198...130,398,044

G

protein tyrosine phosphatase receptor type D

increases expression

geldanamycin results in increased expression of PTPRD mRNA

NCBI chr 4:75,859,474...78,132,282
Ensembl chr 4:75,859,475...78,130,198

G

pygopus 1

increases expression

geldanamycin results in increased expression of PYGO1 mRNA

NCBI chr 9:72,832,927...72,859,868
Ensembl chr 9:72,832,927...72,859,463

G

RAB3B, member RAS oncogene family

increases expression

geldanamycin results in increased expression of RAB3B mRNA

NCBI chr 4:108,736,267...108,800,521
Ensembl chr 4:108,736,260...108,800,521

G

rabaptin, RAB GTPase binding effector protein 1

increases expression

geldanamycin results in increased expression of RABEP1 mRNA

NCBI chr11:70,735,553...70,833,931
Ensembl chr11:70,735,604...70,833,931

G

v-raf-leukemia viral oncogene 1

increases expression
decreases expression
multiple interactions

geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein

PMID:8816498 PMID:19167484 PMID:24450340

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

Rap guanine nucleotide exchange factor (GEF) 2

increases expression

geldanamycin results in increased expression of RAPGEF2 mRNA

NCBI chr 3:78,969,818...79,194,681
Ensembl chr 3:78,969,823...79,193,824

G

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

increases expression

geldanamycin results in increased expression of RASSF8 mRNA

NCBI chr 6:145,692,292...145,766,805
Ensembl chr 6:145,692,474...145,766,805

G

RB-associated KRAB zinc finger

increases expression

geldanamycin results in increased expression of RBAK mRNA

NCBI chr 5:143,157,941...143,166,530
Ensembl chr 5:143,157,941...143,166,530

G

RNA binding motif protein 26

increases expression

geldanamycin results in increased expression of RBM26 mRNA

NCBI chr14:105,344,187...105,418,475
Ensembl chr14:105,344,187...105,414,763

G

RNA binding motif, single stranded interacting protein

increases expression

geldanamycin results in increased expression of RBMS3 mRNA

NCBI chr 9:116,401,814...117,869,900
Ensembl chr 9:116,401,814...117,701,749

G

regulator of calcineurin 1

increases expression

geldanamycin results in increased expression of RCAN1 mRNA

NCBI chr16:92,188,839...92,263,057
Ensembl chr16:92,188,841...92,267,755

G

retinol dehydrogenase 10 (all-trans)

increases expression

geldanamycin results in increased expression of RDH10 mRNA

NCBI chr 1:16,176,106...16,202,774
Ensembl chr 1:16,175,998...16,203,958

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

geldanamycin inhibits the reaction [TNF protein affects the localization of RELA protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of RELA mRNA]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

retroelement silencing factor 1

increases expression

geldanamycin results in increased expression of KIAA1551 mRNA

NCBI chr 6:149,210,907...149,237,161
Ensembl chr 6:149,210,912...149,237,161

G

regulatory factor X, 7

increases expression

geldanamycin results in increased expression of RFX7 mRNA

NCBI chr 9:72,439,346...72,530,231
Ensembl chr 9:72,439,522...72,530,111

G

RNA guanylyltransferase and 5'-phosphatase

increases expression
decreases expression

geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein

PMID:26705709 PMID:30166341

NCBI chr 4:33,310,300...33,502,610
Ensembl chr 4:33,310,311...33,502,614

G

Ro60, Y RNA binding protein

increases expression

geldanamycin results in increased expression of TROVE2 mRNA

NCBI chr 1:143,626,528...143,652,794
Ensembl chr 1:143,626,528...143,652,806

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

geldanamycin results in increased expression of ROCK2 mRNA

NCBI chr12:16,944,808...17,038,275
Ensembl chr12:16,944,896...17,037,824

G

ribosomal protein lateral stalk subunit P0

decreases expression

geldanamycin results in decreased expression of RPLP0 mRNA

NCBI chr 5:115,697,526...115,701,788
Ensembl chr 5:115,697,526...115,701,786

G

rotatin

increases expression

geldanamycin results in increased expression of RTTN mRNA

NCBI chr18:88,989,860...89,149,140
Ensembl chr18:88,989,914...89,149,140

G

RUN and FYVE domain-containing 2

increases expression

geldanamycin results in increased expression of RUFY2 mRNA

NCBI chr10:62,815,947...62,852,988
Ensembl chr10:62,816,002...62,852,989

G

S100 calcium binding protein A4

decreases expression

geldanamycin results in decreased expression of S100A4 mRNA

NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352

G

sterile alpha motif domain containing 5

increases expression

geldanamycin results in increased expression of SAMD5 mRNA

NCBI chr10:9,138,205...9,551,670
Ensembl chr10:9,498,680...9,550,952

G

secretion associated Ras related GTPase 1B

increases expression

geldanamycin results in increased expression of SAR1B mRNA

NCBI chr11:51,654,490...51,682,780
Ensembl chr11:51,654,514...51,682,752

G

secernin 3

increases expression

geldanamycin results in increased expression of SCRN3 mRNA

NCBI chr 2:73,142,980...73,168,158
Ensembl chr 2:73,142,945...73,168,162

G

SCY1-like 2 (S. cerevisiae)

increases expression

geldanamycin results in increased expression of SCYL2 mRNA

NCBI chr10:89,474,582...89,522,179
Ensembl chr10:89,474,583...89,522,147

G

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D

increases expression

geldanamycin results in increased expression of SEMA3D mRNA

NCBI chr 5:12,433,133...12,638,920
Ensembl chr 5:12,433,352...12,638,915

G

SUMO1/sentrin specific peptidase 1

increases expression

geldanamycin results in increased expression of SENP1 mRNA

NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

increases expression

geldanamycin results in increased expression of SERPINE1 mRNA

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

sestrin 3

increases expression

geldanamycin results in increased expression of SESN3 mRNA

NCBI chr 9:14,187,597...14,237,430
Ensembl chr 9:14,186,363...14,244,397

G

SET domain containing 2

increases expression

geldanamycin results in increased expression of SETD2 mRNA

NCBI chr 9:110,361,368...110,447,703
Ensembl chr 9:110,361,665...110,447,701

G

senataxin

increases expression

geldanamycin results in increased expression of SETX mRNA

NCBI chr 2:29,013,600...29,072,483
Ensembl chr 2:29,014,193...29,072,483

G

splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

increases expression

geldanamycin results in increased expression of SFPQ mRNA

NCBI chr 4:126,914,504...126,944,894
Ensembl chr 4:126,915,117...126,930,806

G

sphingomyelin synthase 2

increases expression

geldanamycin results in increased expression of SGMS2 mRNA

NCBI chr 3:131,112,634...131,197,204
Ensembl chr 3:131,112,634...131,197,172

G

suppressor of IKBKE 1

increases expression

geldanamycin results in increased expression of SIKE1 mRNA

NCBI chr 3:102,903,056...102,911,230
Ensembl chr 3:102,903,024...102,915,775

G

SKI3 subunit of superkiller complex

increases expression

geldanamycin results in increased expression of SKIC3 mRNA

NCBI chr13:76,246,837...76,338,437
Ensembl chr13:76,246,853...76,338,435

G

SLAIN motif family, member 2

increases expression

geldanamycin results in increased expression of SLAIN2 mRNA

NCBI chr 5:73,071,705...73,136,184
Ensembl chr 5:73,071,647...73,136,172

G

solute carrier family 16 (monocarboxylic acid transporters), member 1

increases expression

geldanamycin results in increased expression of SLC16A1 mRNA

NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778

G

solute carrier family 16 (monocarboxylic acid transporters), member 7

increases expression

geldanamycin results in increased expression of SLC16A7 mRNA

NCBI chr10:125,055,139...125,225,455
Ensembl chr10:125,055,139...125,225,334

G

solute carrier family 2 (facilitated glucose transporter), member 13

increases expression

geldanamycin results in increased expression of SLC2A13 mRNA

NCBI chr15:91,151,894...91,457,467
Ensembl chr15:91,151,899...91,457,464

G

solute carrier family 38, member 1

increases expression

geldanamycin results in increased expression of SLC38A1 mRNA

NCBI chr15:96,469,299...96,541,396
Ensembl chr15:96,469,299...96,540,794

G

solute carrier family 39 (metal ion transporter), member 6

increases expression

geldanamycin results in increased expression of SLC39A6 mRNA

NCBI chr18:24,712,938...24,736,874
Ensembl chr18:24,712,938...24,736,874

G

solute carrier family 8 (sodium/calcium exchanger), member 1

increases expression

geldanamycin results in increased expression of SLC8A1 mRNA

NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806

G

schlafen 5

increases expression

geldanamycin results in increased expression of SLFN5 mRNA

NCBI chr11:82,842,175...82,855,681
Ensembl chr11:82,842,175...82,855,666

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

increases expression

geldanamycin results in increased expression of SMARCA2 mRNA

NCBI chr19:26,582,578...26,755,721
Ensembl chr19:26,582,450...26,755,722

G

structural maintenance of chromosomes 1A

increases expression

geldanamycin results in increased expression of SMC1A mRNA

NCBI chr X:150,799,386...150,844,969
Ensembl chr X:150,799,424...150,845,690

G

SMC hinge domain containing 1

increases expression

geldanamycin results in increased expression of SMCHD1 mRNA

NCBI chr17:71,651,484...71,782,361
Ensembl chr17:71,651,484...71,782,338

G

SOS Ras/Rho guanine nucleotide exchange factor 2

increases expression

geldanamycin results in increased expression of SOS2 mRNA

NCBI chr12:69,630,535...69,728,626
Ensembl chr12:69,630,536...69,728,626

G

trans-acting transcription factor 4

increases expression

geldanamycin results in increased expression of SP4 mRNA

NCBI chr12:118,195,421...118,265,211
Ensembl chr12:118,198,668...118,265,175

G

spectrin beta, non-erythrocytic 1

increases expression

geldanamycin results in increased expression of SPTBN1 mRNA

NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175

G

Rous sarcoma oncogene

multiple interactions

geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]

PMID:10401681 PMID:17223712

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

signal recognition particle receptor alpha

increases expression

geldanamycin results in increased expression of SRPRA mRNA

NCBI chr 9:35,122,499...35,128,299
Ensembl chr 9:35,111,471...35,159,269

G

serine/arginine repetitive matrix 2

increases expression

geldanamycin results in increased expression of SRRM2 mRNA

NCBI chr17:24,009,501...24,043,715
Ensembl chr17:24,009,506...24,043,715

G

serrate RNA effector molecule homolog (Arabidopsis)

increases expression

geldanamycin results in increased expression of SRRT mRNA

NCBI chr 5:137,293,966...137,306,564
Ensembl chr 5:137,293,973...137,305,928

G

serine/threonine kinase 11

multiple interactions

Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of STK11 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of STK11 protein

NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516

G

striatin, calmodulin binding protein 4

decreases expression

geldanamycin results in decreased expression of STRN4 mRNA

NCBI chr 7:16,549,814...16,574,856
Ensembl chr 7:16,549,814...16,574,856

G

STIP1 homology and U-Box containing protein 1

multiple interactions

geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]

PMID:16037132 PMID:25645596

NCBI chr17:26,049,608...26,051,893
Ensembl chr17:26,049,479...26,052,378

G

SPT16, facilitates chromatin remodeling subunit

increases expression

geldanamycin results in increased expression of SUPT16H mRNA

NCBI chr14:52,397,876...52,434,696
Ensembl chr14:52,397,871...52,434,873

G

TEA domain family member 1

increases expression

geldanamycin results in increased expression of TEAD1 mRNA

NCBI chr 7:112,278,563...112,505,991
Ensembl chr 7:112,278,525...112,506,014

G

tet methylcytosine dioxygenase 2

increases expression

geldanamycin results in increased expression of TET2 mRNA

NCBI chr 3:133,169,438...133,250,882
Ensembl chr 3:133,169,440...133,250,900

G

tissue factor pathway inhibitor

increases expression

geldanamycin results in increased expression of TFPI mRNA

NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119

G

transforming growth factor, beta 2

increases expression

geldanamycin results in increased expression of TGFB2 mRNA

NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186

G

thrombospondin 1

increases expression

geldanamycin results in increased expression of THBS1 mRNA

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

transducin-like enhancer of split 4

increases expression

geldanamycin results in increased expression of TLE4 mRNA

NCBI chr19:14,425,434...14,575,542
Ensembl chr19:14,425,514...14,575,415

G

tousled-like kinase 1

increases expression

geldanamycin results in increased expression of TLK1 mRNA

NCBI chr 2:70,542,751...70,656,505
Ensembl chr 2:70,542,751...70,656,072

G

tolloid-like

increases expression

geldanamycin results in increased expression of TLL1 mRNA

NCBI chr 8:64,466,132...64,659,043
Ensembl chr 8:64,467,965...64,659,305

G

toll-like receptor 4

increases expression

geldanamycin results in increased expression of TLR4 mRNA

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

transmembrane protein 33

increases expression

geldanamycin results in increased expression of TMEM33 mRNA

NCBI chr 5:67,417,908...67,448,804
Ensembl chr 5:67,417,908...67,448,804

G

tropomodulin 3

increases expression

geldanamycin results in increased expression of TMOD3 mRNA

NCBI chr 9:75,405,066...75,466,939
Ensembl chr 9:75,404,989...75,466,939

G

transmembrane and tetratricopeptide repeat containing 3

increases expression

geldanamycin results in increased expression of TMTC3 mRNA

NCBI chr10:100,279,764...100,323,230
Ensembl chr10:100,279,764...100,323,212

G

tumor necrosis factor

multiple interactions

geldanamycin inhibits the reaction [TNF protein affects the localization of RELA protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of EGFR mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of HIF1A mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of RELA mRNA]
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]

PMID:11472980 PMID:12571865 PMID:37586545

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor (ligand) superfamily, member 15

decreases expression

geldanamycin results in decreased expression of TNFSF15 mRNA

NCBI chr 4:63,642,837...63,663,296
Ensembl chr 4:63,642,840...63,663,350

G

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

increases expression

geldanamycin results in increased expression of TNKS2 mRNA

NCBI chr19:36,811,583...36,870,877
Ensembl chr19:36,811,632...36,870,877

G

transducer of ERBB2, 2

increases expression

geldanamycin results in increased expression of TOB2 mRNA

NCBI chr15:81,732,471...81,744,742
Ensembl chr15:81,732,473...81,742,997

G

tropomyosin 4

increases expression

geldanamycin results in increased expression of TPM4 mRNA

NCBI chr 8:72,889,132...72,906,986
Ensembl chr 8:72,884,018...72,906,986

G

tripeptidyl peptidase II

increases expression

geldanamycin results in increased expression of TPP2 mRNA

NCBI chr 1:43,973,130...44,042,160
Ensembl chr 1:43,972,807...44,042,160

G

translocated promoter region, nuclear basket protein

increases expression

geldanamycin results in increased expression of TPR mRNA

NCBI chr 1:150,268,544...150,325,686
Ensembl chr 1:150,268,589...150,325,686

G

tripartite motif-containing 59

increases expression

geldanamycin results in increased expression of TRIM59 mRNA

NCBI chr 3:68,942,625...68,952,075
Ensembl chr 3:68,942,621...68,952,088

G

transformation related protein 53

affects localization
affects expression
multiple interactions

geldanamycin affects the localization of TP53 protein
geldanamycin affects the expression of TP53 protein
Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein]

PMID:17293044 PMID:24211270

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 binding protein 1

increases expression

geldanamycin results in increased expression of TP53BP1 mRNA

NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888

G

transient receptor potential cation channel, subfamily C, member 6

increases expression

geldanamycin results in increased expression of TRPC6 mRNA

NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1]

NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068

G

tetratricopeptide repeat domain 3

increases expression

geldanamycin results in increased expression of TTC3 mRNA

NCBI chr16:94,171,479...94,270,081
Ensembl chr16:94,171,477...94,270,202

G

tubulin, alpha 1A

decreases expression

geldanamycin results in decreased expression of TUBA1A mRNA

NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584

G

ubiquitin-conjugating enzyme E2H

increases expression

geldanamycin results in increased expression of UBE2H mRNA

NCBI chr 6:30,211,288...30,304,538
Ensembl chr 6:30,211,288...30,304,538

G

ubinuclein 2

increases expression

geldanamycin results in increased expression of UBN2 mRNA

NCBI chr 6:38,410,860...38,489,698
Ensembl chr 6:38,410,885...38,501,760

G

UDP-glucose ceramide glucosyltransferase

increases expression

geldanamycin results in increased expression of UGCG mRNA

NCBI chr 4:59,189,452...59,222,833
Ensembl chr 4:59,189,257...59,222,833

G

UDP-glucose glycoprotein glucosyltransferase 1

increases expression

geldanamycin results in increased expression of UGGT1 mRNA

NCBI chr 1:36,179,109...36,283,407
Ensembl chr 1:36,179,108...36,283,801

G

U2AF homology motif (UHM) kinase 1

increases expression

geldanamycin results in increased expression of UHMK1 mRNA

NCBI chr 1:170,020,989...170,043,466
Ensembl chr 1:170,020,989...170,042,966

G

ubiquitin specific peptidase 10

increases expression

geldanamycin results in increased expression of USP10 mRNA

NCBI chr 8:120,637,099...120,684,299
Ensembl chr 8:120,637,099...120,684,299

G

ubiquitin specific peptidase 12

increases expression

geldanamycin results in increased expression of USP12 mRNA

NCBI chr 5:146,671,619...146,731,817
Ensembl chr 5:146,671,619...146,731,816

G

ubiquitin specific peptidase 25

increases expression

geldanamycin results in increased expression of USP25 mRNA

NCBI chr16:76,810,573...76,913,671
Ensembl chr16:76,810,594...76,913,668

G

ubiquitin specific peptidase 36

increases expression

geldanamycin results in increased expression of USP36 mRNA

NCBI chr11:118,150,477...118,181,086
Ensembl chr11:118,150,477...118,181,070

G

vesicle-associated membrane protein, associated protein B and C

increases expression

geldanamycin results in increased expression of VAPB mRNA

NCBI chr 2:173,579,378...173,626,132
Ensembl chr 2:173,579,304...173,626,132

G

voltage-dependent anion channel 3

decreases expression

geldanamycin results in decreased expression of VDAC3 mRNA

NCBI chr 8:23,067,091...23,083,829
Ensembl chr 8:23,067,102...23,083,774

G

very low density lipoprotein receptor

multiple interactions

geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]

NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631

G

vacuole membrane protein 1

increases expression

geldanamycin results in increased expression of VMP1 mRNA

NCBI chr11:86,474,684...86,574,662
Ensembl chr11:86,474,691...86,574,662

G

VPS50 EARP/GARPII complex subunit

increases expression

geldanamycin results in increased expression of VPS50 mRNA

NCBI chr 6:3,498,393...3,603,531
Ensembl chr 6:3,498,382...3,603,531

G

zinc finger, BED type containing 6

increases expression

geldanamycin results in increased expression of ZBED6 mRNA

NCBI chr 1:133,547,606...133,589,112
Ensembl chr 1:133,547,678...133,589,056

G

zinc finger CCCH type containing 11A

increases expression

geldanamycin results in increased expression of ZC3H11A mRNA

NCBI chr 1:133,547,600...133,589,137
Ensembl chr 1:133,547,600...133,589,118

G

zinc finger homeodomain 4

increases expression

geldanamycin results in increased expression of ZFHX4 mRNA

NCBI chr 3:5,276,268...5,480,921
Ensembl chr 3:5,283,586...5,480,917

G

zinc finger protein 207

decreases expression

geldanamycin results in decreased expression of ZNF207 mRNA

NCBI chr11:80,274,105...80,299,387
Ensembl chr11:80,274,105...80,296,559

G

zinc finger protein 326

increases expression

geldanamycin results in increased expression of ZNF326 mRNA

NCBI chr 5:106,024,422...106,063,684
Ensembl chr 5:106,024,431...106,063,684

G

zinc finger protein 518A

increases expression

geldanamycin results in increased expression of ZNF518A mRNA

NCBI chr19:40,882,472...40,906,391
Ensembl chr19:40,883,149...40,906,391

G

zinc finger protein 638

increases expression

geldanamycin results in increased expression of ZNF638 mRNA

NCBI chr 6:83,844,050...83,963,855
Ensembl chr 6:83,844,091...83,966,532

G

zinc finger protein 655

increases expression

geldanamycin results in increased expression of ZNF655 mRNA

NCBI chr 5:145,168,503...145,184,116
Ensembl chr 5:145,168,525...145,184,112

G

zinc finger protein 660

increases expression

geldanamycin results in increased expression of ZNF660 mRNA

NCBI chr 9:122,732,313...122,743,223
Ensembl chr 9:122,732,311...122,743,219

G

zinc finger protein 704

increases expression

geldanamycin results in increased expression of ZNF704 mRNA

NCBI chr 3:9,492,070...9,675,145
Ensembl chr 3:9,492,080...9,675,145

G

zinc finger protein 711

increases expression

geldanamycin results in increased expression of ZNF711 mRNA

NCBI chr X:111,510,259...111,544,767
Ensembl chr X:111,510,223...111,544,767

G

zinc finger protein 770

increases expression

geldanamycin results in increased expression of ZNF770 mRNA

NCBI chr 2:114,023,937...114,031,945
Ensembl chr 2:114,023,942...114,031,950

G

zinc finger RNA binding protein

increases expression

geldanamycin results in increased expression of ZFR mRNA

NCBI chr15:12,117,649...12,185,535
Ensembl chr15:12,117,917...12,185,769

G

zinc finger protein X-linked

increases expression

geldanamycin results in increased expression of ZFX mRNA

NCBI chr X:93,118,237...93,194,250
Ensembl chr X:93,118,237...93,167,308

G

zinc finger, MYND domain containing 11

increases expression

geldanamycin results in increased expression of ZMYND11 mRNA

NCBI chr13:9,734,872...9,816,050
Ensembl chr13:9,734,869...9,815,366

G

ZXD family zinc finger C

increases expression

geldanamycin results in increased expression of ZXDC mRNA

NCBI chr 6:90,346,460...90,380,472
Ensembl chr 6:90,346,474...90,380,472

herbimycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein]

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

aryl-hydrocarbon receptor

multiple interactions
decreases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [herbimycin results in decreased expression of AHR protein]

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

calcium channel, voltage-dependent, T type, alpha 1H subunit

increases activity

herbimycin results in increased activity of CACNA1H protein

NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759

G

CCAAT/enhancer binding protein alpha

multiple interactions

herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

CCAAT/enhancer binding protein beta

multiple interactions

herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

casein beta

multiple interactions

herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]

NCBI chr 5:87,840,478...87,847,288
Ensembl chr 5:87,840,483...87,847,489

G

C-X-C motif chemokine ligand 15

multiple interactions

herbimycin affects the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

herbimycin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
herbimycin inhibits the reaction [Cannabidiol results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:14987951 PMID:20057149 PMID:26187180

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

FBJ osteosarcoma oncogene

multiple interactions

herbimycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

heme oxygenase 1

multiple interactions

herbimycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]
herbimycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]

PMID:9722676 PMID:16171798

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

integrin binding sialoprotein

multiple interactions

herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]

NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335

G

intercellular adhesion molecule 1

multiple interactions

herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

interferon gamma

multiple interactions

herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]
herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]

PMID:10825233 PMID:12044887

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 1 beta

multiple interactions

herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]; herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA]

PMID:14622206 PMID:15808840

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

insulin I

multiple interactions

herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

jun proto-oncogene

multiple interactions

herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

mitogen-activated protein kinase 1

multiple interactions

herbimycin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased phosphorylation of MAPK1 protein]
herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]

PMID:10653605 PMID:11035063

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

matrix metallopeptidase 1b (interstitial collagenase)

multiple interactions

herbimycin inhibits the reaction [Chromium results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nitric oxide synthase 2, inducible

multiple interactions

herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

purinergic receptor P2X, ligand-gated ion channel, 1

multiple interactions

herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]

NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026

G

poly (ADP-ribose) polymerase family, member 1

increases cleavage

herbimycin results in increased cleavage of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

prolactin

multiple interactions

herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]

NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]; herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
herbimycin results in decreased expression of PTGS2 mRNA

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

signal transducer and activator of transcription 1

multiple interactions
decreases activity

herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]
herbimycin results in decreased activity of STAT1 protein

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

tachykinin 1

multiple interactions

herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA]

NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834

G

tissue inhibitor of metalloproteinase 1

multiple interactions

herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tumor necrosis factor

multiple interactions

herbimycin inhibits the reaction [Chromium results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:10653605 PMID:15878362

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

vascular endothelial growth factor A

multiple interactions

herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein]

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

very low density lipoprotein receptor

multiple interactions

herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]

NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631

idebenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cellular communication network factor 2

multiple interactions

idebenone inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

PMID:28648635 PMID:34175429

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

matrix metallopeptidase 9

decreases expression
multiple interactions

idebenone results in decreased expression of MMP9 protein
idebenone inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

neurofilament, light polypeptide

multiple interactions

idebenone inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

idebenone inhibits the reaction [Streptozocin results in increased expression of PPARA protein]
idebenone results in decreased expression of PPARA protein

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

solute carrier family 22 (organic cation transporter), member 2

multiple interactions

idebenone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375

G

superoxide dismutase 2, mitochondrial

multiple interactions

idebenone inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

Ilimaquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

B cell leukemia/lymphoma 2

decreases expression

ilimaquinone results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

decreases expression

ilimaquinone results in decreased expression of BCL2L1 protein

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

caspase 3

multiple interactions
increases cleavage

[ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
ilimaquinone results in increased cleavage of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases cleavage

ilimaquinone results in increased cleavage of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

mitogen-activated protein kinase 1

increases phosphorylation

ilimaquinone results in increased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases phosphorylation

ilimaquinone results in increased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases cleavage

[ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
ilimaquinone results in increased cleavage of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

phospholipase D2

multiple interactions
increases activity

1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein]

NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936

G

tumor necrosis factor receptor superfamily, member 10b

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]
ilimaquinone results in increased expression of TNFRSF10A mRNA; ilimaquinone results in increased expression of TNFRSF10A protein

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

tumor necrosis factor (ligand) superfamily, member 10

multiple interactions

[ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

N-acetyl-1,4-benzoquinone imine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 4930453N24 gene

affects response to substance

C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr16:64,583,267...64,592,735
Ensembl chr16:64,572,114...64,591,524

G

actin alpha 2, smooth muscle, aorta

increases expression
multiple interactions

N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]

PMID:28286204 PMID:29355602

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

adenosine deaminase, RNA-specific, B2

affects response to substance

ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr13:8,252,475...8,818,798
Ensembl chr13:8,252,902...8,818,783

G

activated leukocyte cell adhesion molecule

affects response to substance

ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437

G

aldehyde dehydrogenase family 1, subfamily A3

affects response to substance

ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265

G

bone morphogenetic protein 2

increases expression

N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA

NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805

G

3'(2'), 5'-bisphosphate nucleotidase 2

affects response to substance

BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 4:4,762,484...4,793,306
Ensembl chr 4:4,762,484...4,793,355

G

calcium channel, voltage-dependent, T type, alpha 1H subunit

affects response to substance

CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759

G

caldesmon 1

affects response to substance

CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408

G

coiled-coil domain containing 25

affects response to substance

CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr14:66,074,751...66,104,053
Ensembl chr14:66,074,751...66,104,056

G

CD9 antigen

affects response to substance

CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 6:125,437,229...125,471,723
Ensembl chr 6:125,437,229...125,471,754

G

centrosomal protein 44

affects response to substance

CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 8:56,983,516...57,010,052
Ensembl chr 8:56,984,557...57,004,082

G

cannabinoid receptor 1

affects response to substance

CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831

G

collagen, type I, alpha 1

increases expression
multiple interactions

N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]

PMID:28286204 PMID:29355602

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

increases expression

N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

collagen, type III, alpha 1

increases expression
multiple interactions

N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]

PMID:28286204 PMID:29355602

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

carboxypeptidase A6

affects response to substance

CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 1:10,366,016...10,790,277
Ensembl chr 1:10,394,945...10,790,170

G

cystatin D

affects response to substance

CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 2:149,247,242...149,252,217
Ensembl chr 2:149,246,977...149,252,213

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases abundance

CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine

PMID:19679878 PMID:24661219

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 2, subfamily d, polypeptide 22

increases abundance

CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases abundance
increases chemical synthesis

CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine

PMID:19679878 PMID:20566340 PMID:24661219

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

doublesex and mab-3 related transcription factor 1

affects response to substance

DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr19:25,483,070...25,581,692
Ensembl chr19:25,482,982...25,581,693

G

deoxynucleotidyltransferase, terminal, interacting protein 1

affects response to substance

DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 2:164,587,935...164,610,140
Ensembl chr 2:164,587,903...164,610,527

G

desmocollin 3

affects response to substance

DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr18:20,093,987...20,135,465
Ensembl chr18:20,093,987...20,135,408

G

ethanolamine kinase 2

affects response to substance

ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 1:133,291,308...133,308,056
Ensembl chr 1:133,291,310...133,308,074

G

F-box protein 39

affects response to substance

FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr11:72,205,270...72,210,245
Ensembl chr11:72,205,270...72,210,242

G

fyn-related kinase

affects response to substance

FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr10:34,359,396...34,487,530
Ensembl chr10:34,359,395...34,487,274

G

glutathione peroxidase 1

multiple interactions
affects response to substance

[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione S-transferase, pi 1

affects metabolic processing
multiple interactions
increases glutathionylation
increases metabolic processing

GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine

PMID:24185126 PMID:24552538

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

histone deacetylase 4

affects response to substance

HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421

G

HID1 domain containing

affects response to substance

HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr11:115,238,531...115,261,087
Ensembl chr11:115,238,533...115,258,582

G

interleukin 23 receptor

affects response to substance

IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839

G

potassium inwardly-rectifying channel, subfamily J, member 3

affects response to substance

KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 2:55,301,814...55,488,157
Ensembl chr 2:55,325,982...55,488,157

G

potassium channel, subfamily U, member 1

affects response to substance

KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 8:26,338,656...26,427,971
Ensembl chr 8:26,339,651...26,427,967

G

kelch-like ECH-associated protein 1

multiple interactions
affects metabolic processing

KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein

PMID:18785192 PMID:19246624

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

laminin, alpha 4

affects response to substance

LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184

G

LIM homeobox transcription factor 1 alpha

affects response to substance

LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 1:167,515,864...167,676,310
Ensembl chr 1:167,516,806...167,676,310

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

affects response to substance

MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 5:19,431,787...20,909,790
Ensembl chr 5:19,432,034...20,909,790

G

mitogen-activated protein kinase 1

increases phosphorylation

N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases phosphorylation

N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

multiple C2 domains, transmembrane 1

affects response to substance

MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr13:76,530,481...77,181,403
Ensembl chr13:76,532,259...77,179,929

G

major facilitator superfamily domain containing 4A

affects response to substance

MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 1:131,947,543...131,997,400
Ensembl chr 1:131,950,544...131,995,800

G

microRNA 135a-2

affects response to substance

MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr10:91,907,948...91,908,047
Ensembl chr10:91,907,948...91,908,047

G

matrix metallopeptidase 2

increases expression

N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

microtubule associated tumor suppressor candidate 2

affects response to substance

MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 5:147,894,085...148,252,875
Ensembl chr 5:147,894,130...148,252,875

G

nebulin

affects response to substance

NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 2:52,026,652...52,228,810
Ensembl chr 2:52,026,659...52,268,486

G

nuclear factor, erythroid derived 2, like 2

affects localization
multiple interactions
increases activity

N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein

PMID:18785192 PMID:19246624

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

NHL repeat containing 3

affects response to substance

NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 3:53,359,417...53,370,679
Ensembl chr 3:53,356,004...53,370,753

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases reduction
increases metabolic processing
increases expression

KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine

PMID:17188792 PMID:18785192 PMID:19246624 PMID:24552538

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

N-ribosyldihydronicotinamide quinone reductase 2

multiple interactions

NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine]

NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426

G

pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2

affects response to substance

PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr13:55,874,957...55,924,643
Ensembl chr13:55,875,181...55,924,643

G

Pvt1 oncogene

affects response to substance

PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr15:61,909,835...62,132,064
Ensembl chr15:61,909,817...62,249,945

G

RAB3A interacting protein (rabin3)-like 1

affects response to substance

RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr19:9,979,033...10,015,744
Ensembl chr19:9,979,033...10,015,744

G

RAP1 GTPase activating protein 2

affects response to substance

RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr11:74,274,182...74,501,796
Ensembl chr11:74,274,182...74,501,741

G

solute carrier family 39 (metal ion transporter), member 11

affects response to substance

SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr11:113,135,677...113,541,050
Ensembl chr11:113,135,679...113,540,905

G

slit guidance ligand 2

affects response to substance

SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075

G

sorting nexin 16

affects response to substance

SNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 3:10,482,877...10,505,194
Ensembl chr 3:10,482,877...10,505,162

G

superoxide dismutase 1, soluble

multiple interactions

[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

sperm associated antigen 16

affects response to substance

SPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 1:69,866,031...70,764,291
Ensembl chr 1:69,866,129...70,764,291

G

stabilin 1

affects response to substance

STAB1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr14:30,860,974...30,890,616
Ensembl chr14:30,860,970...30,890,598

G

spectrin repeat containing, nuclear envelope family member 3

affects response to substance

SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr12:104,896,192...104,976,357
Ensembl chr12:104,896,192...104,976,068

G

tachykinin 1

increases secretion

N-acetyl-4-benzoquinoneimine results in increased secretion of TAC1 protein

NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834

G

transforming growth factor, beta 1

increases expression

N-acetyl-4-benzoquinoneimine results in increased expression of TGFB1 mRNA

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tissue inhibitor of metalloproteinase 1

increases expression

N-acetyl-4-benzoquinoneimine results in increased expression of TIMP1 mRNA

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

topoisomerase (DNA) II alpha

decreases activity

N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

tumor protein D52-like 1

affects response to substance

TPD52L1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr10:31,208,369...31,321,989
Ensembl chr10:31,208,372...31,321,954

G

transient receptor potential cation channel, subfamily A, member 1

increases activity
affects response to substance
multiple interactions

N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]

NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086

G

thioredoxin reductase 1

decreases activity
multiple interactions

N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein
Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

ubiquitin associated and SH3 domain containing, A

affects response to substance

UBASH3A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr17:31,426,842...31,478,655
Ensembl chr17:31,426,847...31,465,866

G

ubiquitin-conjugating enzyme E2E 2

affects response to substance

UBE2E2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr14:3,575,429...3,896,133
Ensembl chr14:3,575,429...3,896,121

G

von Willebrand factor C domain containing 2

affects response to substance

VWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr11:11,063,836...11,219,295
Ensembl chr11:11,064,223...11,218,931

G

WAP four-disulfide core domain 3

affects response to substance

WFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine

NCBI chr 2:164,573,222...164,587,914
Ensembl chr 2:164,573,100...164,587,851

Polyporic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dihydroorotate dehydrogenase

decreases activity

polyporic acid results in decreased activity of DHODH protein

NCBI chr 8:110,319,876...110,335,330
Ensembl chr 8:110,317,975...110,335,305

tanespimycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abhydrolase domain containing 11

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of ABHD11 protein

NCBI chr 5:135,038,006...135,041,029
Ensembl chr 5:135,038,006...135,041,029

G

ARP1 actin-related protein 1A, centractin alpha

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of ACTR1A protein

NCBI chr19:46,365,252...46,384,180
Ensembl chr19:46,365,250...46,384,187

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

increases expression

tanespimycin results in increased expression of ADAMTS1 mRNA

NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001

G

anterior gradient 2

multiple interactions
increases expression

[tanespimycin co-treated with VER 155008] results in increased expression of AGR2 protein
tanespimycin analog results in increased expression of AGR2 protein; tanespimycin results in increased expression of AGR2 protein

NCBI chr12:36,042,924...36,054,080
Ensembl chr12:36,042,906...36,054,086

G

aryl-hydrocarbon receptor

multiple interactions
decreases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin results in decreased expression of AHR protein]

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

adenylate kinase 9

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of AK9 protein

NCBI chr10:41,179,433...41,309,565
Ensembl chr10:41,179,976...41,310,530

G

thymoma viral proto-oncogene 1

multiple interactions
affects expression
decreases expression

Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; tanespimycin affects the reaction [Cannabidiol affects the expression of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; tanespimycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
tanespimycin affects the expression of AKT1 protein

PMID:16923571 PMID:17157164 PMID:18566239 PMID:22810956 PMID:26504004

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

albumin

affects binding
multiple interactions

ALB protein binds to tanespimycin
ALB protein inhibits the reaction [Copper results in increased oxidation of tanespimycin analog]

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

aldehyde dehydrogenase family 1, subfamily A1

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of ALDH1A1 protein

NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829

G

anaplastic lymphoma kinase

decreases activity
decreases expression

tanespimycin results in decreased activity of ALK protein mutant form
tanespimycin results in decreased expression of ALK protein; tanespimycin results in decreased expression of ALK protein modified form

PMID:21030459 PMID:21502504

NCBI chr17:72,174,206...72,911,719
Ensembl chr17:72,175,967...72,911,622

G

annexin A1

increases expression

tanespimycin results in increased expression of ANXA1 protein

NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308

G

apoptotic peptidase activating factor 1

multiple interactions
increases expression

Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein]

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

androgen receptor

decreases expression

tanespimycin results in decreased expression of AR protein

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

ATP synthase F1 subunit alpha

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of ATP5F1A protein

NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569

G

ATP synthase F1 subunit beta

decreases expression

tanespimycin analog results in decreased expression of ATP5F1B protein

NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260

G

B cell leukemia/lymphoma 2

decreases expression

tanespimycin results in decreased expression of BCL2 protein

PMID:16923571 PMID:28673683

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

decreases expression

tanespimycin results in decreased expression of BCL2L1 protein

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BCL2 like 11

increases expression

tanespimycin results in increased expression of BCL2L11 protein

NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467

G

Braf transforming gene

decreases expression
increases expression

tanespimycin results in decreased expression of BRAF protein
tanespimycin analog results in increased expression of BRAF protein

PMID:22810956 PMID:31370342

NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397

G

caspase 3

multiple interactions
increases cleavage
increases activity

[tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein; Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased activity of CASP3 protein]; tanespimycin results in increased cleavage of and results in increased activity of CASP3 protein
tanespimycin results in increased cleavage of CASP3 protein
SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]

PMID:15993848 PMID:17157164 PMID:18194434 PMID:19913524 PMID:22810956 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases cleavage
multiple interactions

tanespimycin results in increased cleavage of CASP8 protein
[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions
increases cleavage

[tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein
tanespimycin results in increased cleavage of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

cyclin D1

decreases expression
multiple interactions

tanespimycin results in decreased expression of CCND1 protein
[Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein

PMID:17121904 PMID:17157164

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

chaperonin containing TCP1 subunit 8

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of CCT8 protein

NCBI chr16:87,280,213...87,292,757
Ensembl chr16:87,280,214...87,292,761

G

cell division cycle 25C

multiple interactions
decreases expression

[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein
tanespimycin results in decreased expression of CDC25C protein

PMID:21156818 PMID:22810956

NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586

G

cyclin dependent kinase 1

multiple interactions
affects expression
decreases expression

[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein; tanespimycin affects the reaction [Cannabidiol affects the expression of CDK1 protein]
tanespimycin affects the expression of CDK1 protein
tanespimycin results in decreased expression of CDK1 protein

PMID:21156818 PMID:24784839 PMID:26504004

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 4

decreases expression

tanespimycin results in decreased expression of CDK4 protein

PMID:17157164 PMID:28673683 PMID:34291863

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase 8

decreases expression

tanespimycin results in decreased expression of CDK8 protein

NCBI chr 5:146,167,432...146,239,684
Ensembl chr 5:146,168,040...146,239,684

G

CCAAT/enhancer binding protein beta

decreases expression

tanespimycin results in decreased expression of CEBPB protein

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

carboxylesterase 1D

increases expression

tanespimycin analog results in increased expression of CES1 protein

NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466

G

calcineurin-like EF hand protein 2

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of CHP2 protein

NCBI chr 7:121,807,839...121,823,094
Ensembl chr 7:121,818,719...121,822,047

G

COMM domain containing 1

multiple interactions

tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein]

NCBI chr11:22,849,728...22,934,539
Ensembl chr11:22,846,136...22,932,382

G

cold shock domain containing E1, RNA binding

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of CSDE1 protein

NCBI chr 3:102,927,347...102,965,502
Ensembl chr 3:102,927,742...102,965,502

G

cortactin

multiple interactions
increases expression

[tanespimycin co-treated with VER 155008] results in increased expression of CTTN protein
tanespimycin analog results in increased expression of CTTN protein

NCBI chr 7:143,989,468...144,024,743
Ensembl chr 7:143,989,470...144,024,746

G

cytochrome P450, family 3, subfamily a, polypeptide 13

affects metabolic processing

CYP3A5 protein affects the metabolism of tanespimycin

NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881

G

aspartyl-tRNA synthetase 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of DARS1 protein

NCBI chr 1:128,291,444...128,345,153
Ensembl chr 1:128,291,444...128,345,105

G

dehydrogenase/reductase member 2

increases expression

tanespimycin results in increased expression of DHRS2 protein

NCBI chr14:55,459,464...55,478,897
Ensembl chr14:55,459,464...55,478,892

G

early B cell factor 2

increases expression

tanespimycin analog results in increased expression of EBF2 protein

NCBI chr14:67,470,741...67,668,401
Ensembl chr14:67,470,741...67,668,367

G

enoyl Coenzyme A hydratase domain containing 3

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of ECHDC3 protein

NCBI chr 2:6,193,276...6,217,805
Ensembl chr 2:6,193,276...6,217,844

G

eukaryotic translation elongation factor 1 gamma

multiple interactions
decreases expression

[tanespimycin co-treated with VER 155008] results in decreased expression of EEF1G protein
tanespimycin analog results in decreased expression of EEF1G protein

NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843

G

eukaryotic translation elongation factor 2

increases expression
multiple interactions

tanespimycin analog results in increased expression of EEF2 protein; tanespimycin results in increased expression of EEF2 protein
[tanespimycin co-treated with VER 155008] results in increased expression of EEF2 protein

NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332

G

epidermal growth factor receptor

decreases expression
multiple interactions

tanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR protein
tanespimycin results in increased degradation of and results in decreased expression of EGFR protein

PMID:16061882 PMID:17010675 PMID:22810956 PMID:31370342

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

eukaryotic translation initiation factor 3, subunit I

decreases expression
multiple interactions

tanespimycin results in decreased expression of EIF3I protein
[tanespimycin co-treated with VER 155008] results in decreased expression of EIF3I protein

NCBI chr 4:129,485,767...129,494,441
Ensembl chr 4:129,485,753...129,494,441

G

eukaryotic translation initiation factor 4B

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of EIF4B protein

NCBI chr15:101,982,208...102,005,608
Ensembl chr15:101,982,208...102,005,608

G

eukaryotic translation initiation factor 4H

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of EIF4H protein

NCBI chr 5:134,648,726...134,668,263
Ensembl chr 5:134,648,575...134,668,344

G

echinoderm microtubule associated protein like 5

multiple interactions
increases expression

[tanespimycin co-treated with VER 155008] results in increased expression of EML5 protein
tanespimycin analog results in increased expression of EML5 protein

NCBI chr12:98,752,863...98,867,770
Ensembl chr12:98,753,064...98,867,743

G

enolase 1, alpha non-neuron

increases expression

tanespimycin analog results in increased expression of ENO1 protein

NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases expression

tanespimycin results in increased degradation of and results in decreased expression of ERBB2 protein
tanespimycin results in decreased expression of ERBB2 protein

PMID:16061882 PMID:24784839 PMID:34291863

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

exoribonuclease 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of ERI1 protein

NCBI chr 8:35,932,419...35,962,687
Ensembl chr 8:35,932,407...35,963,350

G

endoplasmic reticulum protein 29

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of ERP29 protein

NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569

G

phenylalanyl-tRNA synthetase, beta subunit

increases expression
multiple interactions

tanespimycin analog results in increased expression of FARSB protein; tanespimycin results in increased expression of FARSB protein
[tanespimycin co-treated with VER 155008] results in increased expression of FARSB protein

NCBI chr 1:78,394,593...78,465,530
Ensembl chr 1:78,394,612...78,465,534

G

fibroblast growth factor 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of FGF1 protein

NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525

G

fibroblast growth factor receptor 3

multiple interactions

tanespimycin results in increased degradation of and results in decreased expression of FGFR3 protein

NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412

G

FMS-like tyrosine kinase 3

decreases expression

tanespimycin results in decreased expression of FLT3 protein

NCBI chr 5:147,267,551...147,337,299
Ensembl chr 5:147,267,551...147,337,299

G

far upstream element (FUSE) binding protein 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of FUBP1 protein

NCBI chr 3:151,916,059...151,942,467
Ensembl chr 3:151,916,059...151,942,463

G

GC-rich sequence DNA binding factor 2

increases expression

tanespimycin analog results in increased expression of GCFC2 protein

NCBI chr 6:81,887,543...81,936,079
Ensembl chr 6:81,900,650...81,936,896

G

glutaminase

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of GLS protein

NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391

G

glycogen synthase kinase 3 beta

decreases expression

tanespimycin results in decreased expression of GSK3B protein modified form

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

general transcription factor II A, 2

increases expression

tanespimycin analog results in increased expression of GTF2A2 protein

NCBI chr 9:69,919,830...69,930,148
Ensembl chr 9:69,919,832...69,930,148

G

general transcription factor II I repeat domain-containing 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of GTF2IRD1 protein

NCBI chr 5:134,386,515...134,485,628
Ensembl chr 5:134,386,510...134,485,570

G

hypoxia inducible factor 1, alpha subunit

multiple interactions

tanespimycin promotes the reaction [COMMD1 protein results in increased degradation of HIF1A protein]

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

histidine triad nucleotide binding protein 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of HINT1 protein

NCBI chr11:54,757,209...54,761,332
Ensembl chr11:54,757,209...54,761,327

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression
multiple interactions

tanespimycin analog results in decreased expression of HSD17B10 protein; tanespimycin results in decreased expression of HSD17B10 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSD17B10 protein

NCBI chr X:150,784,892...150,787,438
Ensembl chr X:150,784,841...150,787,438

G

heat shock factor 1

affects localization
increases activity
multiple interactions

tanespimycin affects the localization of HSF1 protein
tanespimycin results in increased activity of HSF1 protein
[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein

PMID:20090934 PMID:34170685

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 90, alpha (cytosolic), class A member 1

multiple interactions
affects binding
decreases expression

[tanespimycin co-treated with VER 155008] results in decreased expression of HSP90AA1 protein; N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [tanespimycin binds to HSP90AA1 protein]
tanespimycin results in decreased expression of HSP90AA1 protein

PMID:18830594 PMID:22895790 PMID:31370342

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 90 alpha (cytosolic), class B member 1

affects binding

tanespimycin binds to HSP90AB1 protein

NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197

G

heat shock protein 1A

multiple interactions
increases expression

[tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein
tanespimycin analog results in increased expression of HSPA1A protein

PMID:20090934 PMID:31370342

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 1B

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of HSPA1B protein

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

heat shock protein 4

increases expression
multiple interactions

tanespimycin results in increased expression of HSPA4 protein
[tanespimycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin

NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284

G

heat shock protein 5

increases expression

tanespimycin results in increased expression of HSPA5 protein

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 1 (chaperonin)

decreases expression
multiple interactions

tanespimycin results in decreased expression of HSPD1 protein
[tanespimycin co-treated with VER 155008] results in decreased expression of HSPD1 protein

PMID:23144451 PMID:31370342

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

insulin-like growth factor I receptor

decreases expression
affects expression

tanespimycin results in decreased expression of IGF1R protein
tanespimycin affects the expression of IGF1R protein

NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416

G

interleukin enhancer binding factor 3

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of ILF3 protein

NCBI chr 9:21,278,964...21,316,659
Ensembl chr 9:21,279,167...21,316,657

G

potassium channel, subfamily V, member 2

multiple interactions
decreases expression

[tanespimycin co-treated with VER 155008] results in decreased expression of KCNV2 protein
tanespimycin analog results in decreased expression of KCNV2 protein

NCBI chr19:27,299,461...27,314,579
Ensembl chr19:27,299,988...27,314,579

G

lysine (K)-specific demethylase 3A

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of KDM3A protein

NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974

G

kinase insert domain protein receptor

decreases expression
affects expression

tanespimycin results in decreased expression of KDR protein
tanespimycin affects the expression of KDR protein

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

KIT proto-oncogene receptor tyrosine kinase

decreases expression
multiple interactions

tanespimycin results in decreased expression of KIT protein
tanespimycin results in increased degradation of and results in decreased expression of KIT protein

PMID:16061882 PMID:16213582 PMID:22810956

NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382

G

La ribonucleoprotein 7, transcriptional regulator

increases expression

tanespimycin analog results in increased expression of LARP7 protein

NCBI chr 3:127,330,363...127,346,998
Ensembl chr 3:127,330,363...127,346,998

G

lymphocyte cytosolic protein 1

multiple interactions
increases expression

[tanespimycin co-treated with VER 155008] results in increased expression of LCP1 protein
tanespimycin analog results in increased expression of LCP1 protein

NCBI chr14:75,368,570...75,468,282
Ensembl chr14:75,368,541...75,468,282

G

lactate dehydrogenase A

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of LDHA protein

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

lactate dehydrogenase B

increases expression

tanespimycin analog results in increased expression of LDHB protein

NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683

G

lamin A

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of LMNA protein

NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263

G

leucine-rich PPR-motif containing

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of LRPPRC protein

NCBI chr17:85,012,675...85,098,214
Ensembl chr17:85,012,675...85,098,217

G

mitogen-activated protein kinase kinase 6

multiple interactions

[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]

NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348

G

mitogen-activated protein kinase 1

decreases phosphorylation
affects expression
multiple interactions

tanespimycin results in decreased phosphorylation of MAPK1 protein
tanespimycin affects the expression of MAPK1 protein
tanespimycin affects the reaction [Cannabidiol affects the expression of MAPK1 protein]
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK1 protein

PMID:17157164 PMID:20090934 PMID:21502504 PMID:22810956 PMID:24784839 More...

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

decreases phosphorylation
multiple interactions
affects expression

tanespimycin results in decreased phosphorylation of MAPK3 protein
tanespimycin affects the reaction [Cannabidiol affects the expression of MAPK3 protein]
tanespimycin affects the expression of MAPK3 protein
tanespimycin results in increased expression of and results in decreased phosphorylation of MAPK3 protein

PMID:17157164 PMID:20090934 PMID:21502504 PMID:22810956 PMID:24784839 More...

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

myeloid cell leukemia sequence 1

decreases expression

tanespimycin results in decreased expression of MCL1 protein

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

transformed mouse 3T3 cell double minute 2

increases degradation

tanespimycin results in increased degradation of MDM2 protein

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

met proto-oncogene

decreases expression

tanespimycin results in decreased expression of MET protein

NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979

G

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

multiple interactions
decreases expression

[tanespimycin co-treated with VER 155008] results in decreased expression of MIF protein
tanespimycin results in decreased expression of MIF protein

NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074

G

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of MLLT10 protein

NCBI chr 2:18,059,971...18,217,201
Ensembl chr 2:18,060,048...18,217,199

G

matrix metallopeptidase 2

multiple interactions

tanespimycin affects the reaction [Nickel results in increased activity of MMP2 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP2 mRNA]

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions

tanespimycin affects the reaction [Nickel results in increased activity of MMP9 protein]; tanespimycin inhibits the reaction [Nickel results in increased expression of MMP9 mRNA]

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

moesin

increases expression

tanespimycin analog results in increased expression of MSN protein

NCBI chr X:95,139,651...95,212,159
Ensembl chr X:95,139,648...95,212,158

G

methylthioadenosine phosphorylase

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of MTAP protein

NCBI chr 4:89,055,607...89,099,327
Ensembl chr 4:89,055,359...89,099,318

G

MTSS I-BAR domain containing 1

increases expression

tanespimycin results in increased expression of MTSS1 mRNA

NCBI chr15:58,813,083...58,955,805
Ensembl chr15:58,813,083...58,953,854

G

nicotinamide phosphoribosyltransferase

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of NAMPT protein

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

N-acetylneuraminic acid synthase (sialic acid synthase)

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of NANS protein

NCBI chr 4:46,489,319...46,503,439
Ensembl chr 4:46,489,248...46,503,632

G

nucleolin

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of NCL protein

NCBI chr 1:86,272,441...86,287,177
Ensembl chr 1:86,272,441...86,287,122

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

increases expression
decreases phosphorylation

tanespimycin results in increased expression of NFKBIA protein
tanespimycin results in decreased phosphorylation of NFKBIA protein

PMID:11835313 PMID:22810956

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nitric oxide synthase 2, inducible

multiple interactions
decreases expression

Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases response to substance
increases reduction
increases abundance

[5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased abundance of tanespimycin metabolite; [5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione results in decreased activity of NQO1 protein] which results in decreased susceptibility to tanespimycin; [NQO1 protein results in increased reduction of tanespimycin] which results in increased chemical synthesis of tanespimycin metabolite; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein; [tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein
NQO1 protein results in increased susceptibility to tanespimycin
NQO1 protein results in increased abundance of tanespimycin; NQO1 protein results in increased abundance of tanespimycin metabolite

PMID:10564678 PMID:21156818 PMID:24552538

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

ornithine aminotransferase

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of OAT protein

NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127

G

proliferation-associated 2G4

increases expression
multiple interactions

tanespimycin analog results in increased expression of PA2G4 protein; tanespimycin results in increased expression of PA2G4 protein
[tanespimycin co-treated with VER 155008] results in increased expression of PA2G4 protein

NCBI chr10:128,393,635...128,401,803
Ensembl chr10:128,393,635...128,401,856

G

poly (ADP-ribose) polymerase family, member 1

increases cleavage

tanespimycin results in increased cleavage of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

poly (ADP-ribose) polymerase family, member 2

increases expression

tanespimycin analog results in increased expression of PARP2 protein

NCBI chr14:51,045,347...51,058,758
Ensembl chr14:51,045,298...51,058,758

G

platelet derived growth factor receptor, beta polypeptide

decreases expression

tanespimycin results in decreased expression of PDGFRB protein

NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133

G

protein disulfide isomerase associated 4

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of PDIA4 protein

NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364

G

profilin 1

increases expression

tanespimycin analog results in increased expression of PFN1 protein

NCBI chr11:70,542,670...70,547,625
Ensembl chr11:70,542,676...70,545,470

G

progesterone receptor

decreases expression

tanespimycin results in decreased expression of PGR protein

NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612

G

phosphatidylinositol-5-phosphate 4-kinase, type II, gamma

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of PIP4K2C protein

NCBI chr10:127,032,936...127,047,508
Ensembl chr10:127,032,936...127,047,454

G

pyruvate kinase, muscle

decreases expression

tanespimycin results in decreased expression of PKM protein

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

pinin

increases expression

tanespimycin results in increased expression of PNN mRNA

NCBI chr12:59,113,705...59,120,803
Ensembl chr12:59,113,670...59,120,784

G

Prkr interacting protein 1 (IL11 inducible)

increases expression

tanespimycin analog results in increased expression of PRKRIP1 protein

NCBI chr 5:136,209,211...136,227,808
Ensembl chr 5:136,206,981...136,227,817

G

phosphoribosyl pyrophosphate synthetase 2

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of PRPS2 protein

NCBI chr X:166,129,316...166,165,887
Ensembl chr X:166,129,318...166,165,745

G

proteasome subunit alpha 6

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of PSMA6 protein

NCBI chr12:55,431,007...55,465,244
Ensembl chr12:55,431,007...55,465,239

G

proteasome subunit alpha 7

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of PSMA7 protein

NCBI chr 2:179,678,160...179,684,257
Ensembl chr 2:179,678,167...179,684,226

G

RAB17, member RAS oncogene family

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of RAB17 protein

NCBI chr 1:90,885,855...90,897,395
Ensembl chr 1:90,885,855...90,897,383

G

v-raf-leukemia viral oncogene 1

decreases expression

tanespimycin results in decreased expression of RAF1 protein

PMID:10564678 PMID:34291863

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

tanespimycin results in decreased phosphorylation of RB1 protein
[tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

radixin

increases expression
multiple interactions

tanespimycin analog results in increased expression of RDX protein
[tanespimycin co-treated with VER 155008] results in increased expression of RDX protein

NCBI chr 9:51,958,450...52,000,038
Ensembl chr 9:51,958,473...52,011,763

G

ribosomal protein lateral stalk subunit P0

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of RPLP0 protein

NCBI chr 5:115,697,526...115,701,788
Ensembl chr 5:115,697,526...115,701,786

G

ribosomal protein S6

decreases phosphorylation
decreases expression

tanespimycin results in decreased phosphorylation of RPS6 protein
tanespimycin results in decreased expression of RPS6 protein

PMID:17121904 PMID:27255535

NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649

G

runt related transcription factor 1

decreases expression

tanespimycin results in decreased expression of RUNX1 protein mutant form

NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037

G

RUNX1 translocation partner 1

decreases expression

tanespimycin results in decreased expression of RUNX1T1 protein mutant form

NCBI chr 4:13,742,628...13,895,056
Ensembl chr 4:13,743,436...13,893,649

G

selenium binding protein 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of SELENBP1 protein

NCBI chr 3:94,840,394...94,852,069
Ensembl chr 3:94,840,367...94,852,069

G

serine (or cysteine) peptidase inhibitor, clade B, member 5

increases expression

tanespimycin results in increased expression of SERPINB5 mRNA

NCBI chr 1:106,788,905...106,811,078
Ensembl chr 1:106,788,903...106,811,078

G

serine hydroxymethyltransferase 2 (mitochondrial)

decreases expression

tanespimycin analog results in decreased expression of SHMT2 protein

NCBI chr10:127,352,992...127,358,313
Ensembl chr10:127,352,992...127,358,313

G

superoxide dismutase 2, mitochondrial

increases abundance
increases response to substance

SOD2 protein results in increased abundance of tanespimycin metabolite
SOD2 protein results in increased susceptibility to tanespimycin

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

SRC kinase signaling inhibitor 1

increases expression
multiple interactions

tanespimycin analog results in increased expression of SRCIN1 protein; tanespimycin results in increased expression of SRCIN1 protein
[tanespimycin co-treated with VER 155008] results in increased expression of SRCIN1 protein

NCBI chr11:97,400,166...97,466,059
Ensembl chr11:97,400,166...97,467,012

G

transgelin 2

multiple interactions

[tanespimycin co-treated with VER 155008] results in increased expression of TAGLN2 protein

NCBI chr 1:172,327,813...172,334,942
Ensembl chr 1:172,327,614...172,334,947

G

tissue inhibitor of metalloproteinase 3

increases expression

tanespimycin results in increased expression of TIMP3 mRNA

NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370

G

tumor necrosis factor (ligand) superfamily, member 10

multiple interactions

[tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [tanespimycin co-treated with TNFSF10 protein] results in increased activity of CASP3 protein

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

transformation related protein 53

decreases expression

tanespimycin results in decreased expression of TP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

thymidine phosphorylase

decreases expression
multiple interactions

tanespimycin results in decreased expression of TYMP mRNA; tanespimycin results in decreased expression of TYMP protein
[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]

NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242

G

thymidylate synthase

decreases expression

tanespimycin results in decreased expression of TYMS protein

NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615

G

UDP-glucose dehydrogenase

increases expression

tanespimycin analog results in increased expression of UGDH protein; tanespimycin results in increased expression of UGDH protein

NCBI chr 5:65,570,550...65,593,185
Ensembl chr 5:65,570,564...65,593,292

G

UDP-glucose pyrophosphorylase 2

decreases expression

tanespimycin results in decreased expression of UGP2 protein

NCBI chr11:21,271,126...21,321,267
Ensembl chr11:21,271,138...21,321,201

G

villin 1

increases expression

tanespimycin analog results in increased expression of VIL1 protein

NCBI chr 1:74,448,543...74,474,719
Ensembl chr 1:74,448,535...74,474,718

G

X-linked inhibitor of apoptosis

multiple interactions

[tanespimycin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

tyrosyl-tRNA synthetase 1

multiple interactions

[tanespimycin co-treated with VER 155008] results in decreased expression of YARS1 protein

NCBI chr 4:129,083,595...129,113,033
Ensembl chr 4:129,083,553...129,113,400

G

zyg-ll family member B, cell cycle regulator

increases expression
multiple interactions

tanespimycin analog results in increased expression of ZYG11B protein
[tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B protein

NCBI chr 4:108,084,947...108,158,276
Ensembl chr 4:108,086,921...108,158,293

tetrachloro-1,4-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

Chloranil results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

multiple interactions
decreases activity

Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

endothelial cell-specific molecule 1

increases expression

Chloranil results in increased expression of ESM1 mRNA

NCBI chr13:113,346,193...113,354,638
Ensembl chr13:113,346,193...113,354,632

G

F-box protein 32

increases expression

Chloranil results in increased expression of FBXO32 mRNA

NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328

G

ferritin light polypeptide 1

multiple interactions
increases expression

[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of FTL mRNA
Chloranil results in increased expression of FTL mRNA; Chloranil results in increased expression of FTL protein

NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308

G

golgi SNAP receptor complex member 2

increases expression

Chloranil results in increased expression of GOSR2 mRNA

NCBI chr11:103,567,675...103,590,139
Ensembl chr11:103,567,675...103,588,724

G

glutamic pyruvic transaminase, soluble

increases activity
multiple interactions

Chloranil results in increased activity of GPT protein
Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

heme oxygenase 1

multiple interactions
increases expression

[Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein
Chloranil results in increased expression of HMOX1 protein

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

interleukin 1 beta

increases expression
multiple interactions

Chloranil results in increased expression of IL1B protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

increases expression
multiple interactions

Chloranil results in increased expression of IL6 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

nitric oxide synthase 2, inducible

increases expression
multiple interactions

Chloranil results in increased expression of NOS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NAD(P)H dehydrogenase, quinone 1

increases expression
multiple interactions

Chloranil results in increased expression of NQO1 protein
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Chloranil results in increased expression of PTGS2 protein
Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
increases expression
affects localization

Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

Rho family GTPase 3

increases expression

Chloranil results in increased expression of RND3 mRNA

NCBI chr 2:51,020,451...51,039,123
Ensembl chr 2:51,020,450...51,039,123

G

tet methylcytosine dioxygenase 1

multiple interactions

TET1 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]

NCBI chr10:62,640,349...62,723,242
Ensembl chr10:62,640,349...62,744,775

G

tet methylcytosine dioxygenase 2

multiple interactions

TET2 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET2 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]

NCBI chr 3:133,169,438...133,250,882
Ensembl chr 3:133,169,440...133,250,900

G

tumor necrosis factor

increases expression

Chloranil results in increased expression of TNF protein

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

ubiquitin C

increases expression
multiple interactions

Chloranil results in increased expression of UBC mRNA
[Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of UBC mRNA

NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266

thymoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

thymoquinone inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein]; thymoquinone inhibits the reaction [Cytarabine results in increased activity of ACHE protein]

PMID:27206696 PMID:36419121

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

actin alpha 2, smooth muscle, aorta

multiple interactions

thymoquinone inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

PMID:27375216 PMID:27688165 PMID:31935363

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

adenosine deaminase

multiple interactions

thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of ADA protein]

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

G

a disintegrin and metallopeptidase domain 17

decreases expression

thymoquinone results in decreased expression of ADAM17 protein

NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633

G

alpha fetoprotein

multiple interactions

thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein alternative form]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

PMID:24012840 PMID:29923357 PMID:35437842

NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766

G

apoptosis-inducing factor, mitochondrion-associated 1

increases expression

thymoquinone results in increased expression of AIFM1 protein

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

thymoma viral proto-oncogene 1

decreases phosphorylation
multiple interactions

thymoquinone results in decreased phosphorylation of AKT1 protein
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT1 protein]

PMID:31298468 PMID:36193556

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

thymoma viral proto-oncogene 2

multiple interactions

thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of AKT2 protein]

NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251

G

amyloid beta precursor protein

multiple interactions

thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

androgen receptor

multiple interactions

thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of AR protein]

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

activating transcription factor 4

increases expression

thymoquinone results in increased expression of ATF4 mRNA; thymoquinone results in increased expression of ATF4 protein

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 6

increases expression

thymoquinone results in increased expression of ATF6 mRNA; thymoquinone results in increased expression of ATF6 protein

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

autophagy related 12

decreases expression

thymoquinone results in decreased expression of ATG12 protein

NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647

G

autophagy related 5

decreases expression

thymoquinone results in decreased expression of ATG5 protein

NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287

G

autophagy related 7

decreases expression

thymoquinone results in decreased expression of ATG7 protein

NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575

G

BCL2-associated agonist of cell death

decreases expression

thymoquinone results in decreased expression of BAD protein

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated X protein

increases expression
multiple interactions

thymoquinone results in increased expression of BAX protein
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]
[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of BAX mRNA; thymoquinone results in increased expression of and affects the localization of BAX protein
thymoquinone affects the reaction [Ethanol affects the expression of BAX mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; thymoquinone inhibits the reaction [Ethanol results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX mRNA]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of BAX protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]

PMID:24289642 PMID:29085585 PMID:29710533 PMID:29981725 PMID:30558456 More...

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions
decreases expression

[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of BCL2 mRNA; DDIT3 protein affects the reaction [thymoquinone results in decreased expression of BCL2 protein]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
thymoquinone affects the reaction [Ethanol affects the expression of BCL2 mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]; thymoquinone inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]

PMID:21609759 PMID:24289642 PMID:29085585 PMID:29710533 PMID:29923357 More...

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

decreases expression

thymoquinone results in decreased expression of BCL2L1 protein

PMID:29981725 PMID:31433961 PMID:34627931

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BH3 interacting domain death agonist

decreases expression

thymoquinone results in decreased expression of BID protein

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

baculoviral IAP repeat-containing 5

decreases expression
multiple interactions

thymoquinone results in decreased expression of BIRC5 protein
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of BIRC5 protein]; thymoquinone promotes the reaction [Doxorubicin results in decreased expression of BIRC5 protein]

PMID:31433961 PMID:34605108 PMID:34627931

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

caspase 1

multiple interactions

thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 12

decreases expression

thymoquinone results in decreased expression of CASP12 protein

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

increases expression
increases activity
multiple interactions
increases cleavage

thymoquinone results in increased expression of CASP3 protein modified form
thymoquinone results in increased activity of CASP3 protein
Doxorubicin promotes the reaction [thymoquinone results in increased activity of CASP3 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CASP3 protein]; thymoquinone promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
thymoquinone results in increased cleavage of CASP3 protein
4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein; [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of CASP3 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein]; MAPK14 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein]; thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein
thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [nonylphenol results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased cleavage of CASP3 protein]; thymoquinone inhibits the reaction [sodium arsenate results in increased expression of CASP3 mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]

PMID:29085585 PMID:29710533 PMID:29981725 PMID:30558456 PMID:31298468 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

increases cleavage
multiple interactions
increases expression

thymoquinone results in increased cleavage of CASP7 protein
Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP7 protein modified form]

PMID:29981725 PMID:31433961 PMID:34627931

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

multiple interactions

thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP8 protein]

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions
increases activity
increases expression
increases cleavage

thymoquinone inhibits the reaction [Ethanol results in increased cleavage of CASP9 protein]
Doxorubicin promotes the reaction [thymoquinone results in increased activity of CASP9 protein]; thymoquinone promotes the reaction [Doxorubicin results in increased activity of CASP9 protein]
thymoquinone results in increased expression of CASP9 protein modified form
Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP9 protein modified form]

PMID:29085585 PMID:29981725 PMID:31298468 PMID:31433961 PMID:34605108 More...

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions
increases activity

thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [cyhalothrin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of CAT mRNA]; thymoquinone inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
thymoquinone results in increased activity of CAT protein

PMID:10755708 PMID:20957680 PMID:20972371 PMID:21382363 PMID:22450443 More...

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cyclin B1

decreases expression

thymoquinone results in decreased expression of CCNB1 protein

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin D1

multiple interactions
decreases expression

[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of CCND1 mRNA; Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND1 protein]
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of CCND1 protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of CCND1 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of CCND1 protein]
thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]
thymoquinone results in decreased expression of CCND1 mRNA; thymoquinone results in decreased expression of CCND1 protein

PMID:24012840 PMID:24289642 PMID:31433961 PMID:32112862 PMID:34605108 More...

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin D2

decreases expression
multiple interactions

thymoquinone results in decreased expression of CCND2 protein
Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND2 protein]

NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156

G

cyclin D3

decreases expression
multiple interactions

thymoquinone results in decreased expression of CCND3 protein
Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND3 protein]

PMID:32112862 PMID:34627931

NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616

G

cyclin E1

multiple interactions

thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

CD14 antigen

multiple interactions

thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

G

CD44 antigen

decreases expression

thymoquinone results in decreased expression of CD44 protein

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

cadherin 1

multiple interactions
increases expression

CTNNB1 protein inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; thymoquinone promotes the reaction [cordycepin results in increased expression of CDH1 protein]; XAV939 promotes the reaction [thymoquinone results in increased expression of CDH1 protein]

PMID:32112862 PMID:35774120

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 2

decreases expression
multiple interactions

thymoquinone results in decreased expression of CDH2 protein
CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of CDH2 protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of CDH2 protein]

PMID:32112862 PMID:35774120

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

cyclin dependent kinase 2

decreases expression

thymoquinone results in decreased expression of CDK2 protein

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase 4

multiple interactions

thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of CDK4 protein]

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase inhibitor 1A

multiple interactions

thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]
[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of CDKN1A mRNA

PMID:24012840 PMID:24289642

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

CEA cell adhesion molecule 20

multiple interactions
decreases expression

Doxorubicin promotes the reaction [thymoquinone results in decreased expression of CEACAM20 protein]; thymoquinone promotes the reaction [Doxorubicin results in decreased expression of CEACAM20 protein]

NCBI chr 7:19,699,277...19,725,038
Ensembl chr 7:19,699,337...19,725,029

G

conserved helix-loop-helix ubiquitous kinase

multiple interactions

[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of CHUK mRNA

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

collagen, type I, alpha 1

multiple interactions

thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]
thymoquinone inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]

PMID:27375216 PMID:27688165 PMID:31935363

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type IV, alpha 1

multiple interactions

thymoquinone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

catenin beta 1

decreases expression
multiple interactions

thymoquinone results in decreased expression of CTNNB1 mRNA
thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of CTNNB1 mRNA]
CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of CDH2 protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; CTNNB1 protein inhibits the reaction [thymoquinone results in increased expression of CDH1 protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; thymoquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CTNNB1 protein]; thymoquinone results in decreased expression of and results in increased phosphorylation of and results in decreased activity of CTNNB1 protein; XAV939 promotes the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]
thymoquinone results in decreased expression of CTNNB1 protein

PMID:32112862 PMID:34234489

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

C-X-C motif chemokine receptor 4

increases expression

thymoquinone results in increased expression of CXCR4 mRNA

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome c, somatic

increases expression
multiple interactions

thymoquinone results in increased expression of CYCS protein
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CYCS protein]

PMID:31433961 PMID:36193556

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP2E1 protein]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [thymoquinone results in decreased expression of BCL2 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased activity of and results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased cleavage of PARP1 protein]
thymoquinone inhibits the reaction [Doxorubicin results in increased expression of DDIT3 protein]
thymoquinone results in increased expression of DDIT3 mRNA; thymoquinone results in increased expression of DDIT3 protein

PMID:29981725 PMID:34392583

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

dynamin 1-like

multiple interactions

thymoquinone inhibits the reaction [Rotenone results in increased expression of DNM1L protein]

NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

thymoquinone results in increased expression of EIF2AK3 protein

NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229

G

epoxide hydrolase 1, microsomal

multiple interactions

thymoquinone inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPHX1 mRNA]

NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469

G

endoplasmic reticulum to nucleus signalling 1

increases expression

thymoquinone results in increased expression of ERN1 mRNA; thymoquinone results in increased expression of ERN1 protein

NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678

G

FBJ osteosarcoma oncogene

multiple interactions

thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of FOS mRNA]

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

glial fibrillary acidic protein

multiple interactions

thymoquinone inhibits the reaction [nonylphenol results in increased expression of GFAP protein]

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gamma-glutamyltransferase 1

multiple interactions

thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of GGT1 protein]

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

glypican 3

multiple interactions

thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GPC3 protein]

NCBI chr X:51,361,303...51,702,851
Ensembl chr X:51,361,303...51,702,827

G

glutamic pyruvic transaminase, soluble

multiple interactions

thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased activity of GPT protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]; thymoquinone inhibits the reaction [Ethanol results in increased activity of GPT protein]

PMID:29085585 PMID:29923357 PMID:35437842

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

multiple interactions

thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of GPX1 protein]

PMID:28734741 PMID:36193556

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glycogen synthase kinase 3 beta

decreases phosphorylation
multiple interactions

thymoquinone results in decreased phosphorylation of GSK3B protein
thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]
Lithium Chloride inhibits the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]; XAV939 promotes the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]

PMID:32112862 PMID:33315269

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione reductase

multiple interactions

thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]

PMID:27206696 PMID:30558456

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, pi 1

multiple interactions

thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein]

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

H2A.X variant histone

increases phosphorylation

thymoquinone results in increased phosphorylation of H2AX protein

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

hypoxia inducible factor 1, alpha subunit

multiple interactions

thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HIF1A protein]

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]
thymoquinone results in increased expression of HMOX1 mRNA; thymoquinone results in increased expression of HMOX1 protein

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

HNF1 homeobox A

decreases expression

thymoquinone results in decreased expression of HNF1A mRNA

NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153

G

heat shock protein 5

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]
thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]
thymoquinone results in increased expression of HSPA5 mRNA; thymoquinone results in increased expression of HSPA5 protein

PMID:29981725 PMID:34392583

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

interferon gamma

multiple interactions
decreases expression

thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IFNG protein]
thymoquinone results in decreased expression of IFNG mRNA; thymoquinone results in decreased expression of IFNG protein
[Benzo(a)pyrene co-treated with thymoquinone] results in decreased expression of IFNG protein

PMID:22450443 PMID:24289642 PMID:26645134

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 10

multiple interactions
increases expression

thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL10 protein]; thymoquinone inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of IL10 mRNA]
thymoquinone results in increased expression of IL10 mRNA; thymoquinone results in increased expression of IL10 protein

PMID:22450443 PMID:25268985 PMID:26645134 PMID:34234489

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 17A

multiple interactions

thymoquinone inhibits the reaction [Doxorubicin results in increased expression of IL17A protein]

NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression

thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
thymoquinone results in increased expression of IL1B protein
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL1B protein]
thymoquinone results in decreased expression of IL1B mRNA; thymoquinone results in decreased expression of IL1B protein

PMID:22450443 PMID:26645134 PMID:29405769 PMID:31935363

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 4

multiple interactions
increases expression

thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in decreased expression of IL4 protein]
thymoquinone results in increased expression of IL4 mRNA; thymoquinone results in increased expression of IL4 protein

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 6

decreases expression
multiple interactions

thymoquinone results in decreased expression of IL6 mRNA; thymoquinone results in decreased expression of IL6 protein
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of IL6 protein]
thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [Ethanol results in increased expression of IL6 protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]

PMID:22450443 PMID:25268985 PMID:26645134 PMID:29085585 PMID:30558456 More...

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 receptor, alpha

multiple interactions
decreases expression

Doxorubicin promotes the reaction [thymoquinone results in decreased expression of IL6R mRNA]

NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503

G

insulin I

multiple interactions

thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INS1 protein]; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased secretion of INS1 protein]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

interferon regulatory factor 3

increases expression
multiple interactions

thymoquinone results in increased expression of IRF3 mRNA
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IRF3 mRNA]

NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272

G

insulin receptor substrate 1

multiple interactions

thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of IRS1 protein]

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

Janus kinase 2

decreases phosphorylation
multiple interactions

thymoquinone results in decreased phosphorylation of JAK2 protein
Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of JAK2 protein]

PMID:34605108 PMID:34627931

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

lymphoid enhancer binding factor 1

decreases expression

thymoquinone results in decreased expression of LEF1 mRNA

NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005

G

microtubule-associated protein 1 light chain 3 alpha

increases lipidation

thymoquinone results in increased lipidation of MAP1LC3A protein

NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993

G

mitogen-activated protein kinase 1

decreases phosphorylation
multiple interactions
increases phosphorylation

thymoquinone results in decreased phosphorylation of MAPK1 protein
[Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [[thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK1 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; [thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK1 protein; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]

PMID:27060453 PMID:34173702 PMID:36176197

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

multiple interactions

MAPK14 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased cleavage of CASP3 protein]; MAPK14 protein promotes the reaction [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone]

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation
decreases response to substance
decreases phosphorylation

thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK3 protein]
thymoquinone results in increased phosphorylation of MAPK3 protein
MAPK3 protein results in decreased susceptibility to thymoquinone
[Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [[thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK3 protein]; [Temozolomide results in decreased susceptibility to Temozolomide] promotes the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; [thymoquinone co-treated with SB 203580] results in increased phosphorylation of MAPK3 protein; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]; MAPK3 protein inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein]; MAPK3 protein promotes the reaction [[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone]; U 0126 inhibits the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]
thymoquinone results in decreased phosphorylation of MAPK3 protein

PMID:27060453 PMID:29923357 PMID:34173702 PMID:36176197

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

transformed mouse 3T3 cell double minute 2

decreases expression

thymoquinone results in decreased expression of MDM2 protein

PMID:31433961 PMID:34627931

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

met proto-oncogene

decreases expression
increases expression

thymoquinone results in decreased expression of MET mRNA
thymoquinone results in increased expression of MET mRNA

PMID:31812774 PMID:32112862

NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein; [Temozolomide results in decreased susceptibility to Temozolomide] inhibits the reaction [thymoquinone results in decreased expression of MGMT protein]; MAPK3 protein promotes the reaction [[[Temozolomide results in decreased susceptibility to Temozolomide] which affects the susceptibility to thymoquinone] which results in increased expression of MGMT protein]

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

G

microRNA 125a

increases expression

thymoquinone results in increased expression of MIR125A mRNA

NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141

G

antigen identified by monoclonal antibody Ki 67

decreases expression

thymoquinone results in decreased expression of MKI67 protein

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

matrix metallopeptidase 13

multiple interactions

thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

matrix metallopeptidase 2

decreases expression
multiple interactions

thymoquinone results in decreased expression of MMP2 protein
CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; thymoquinone results in decreased expression of and results in decreased activity of MMP2 protein

PMID:27060453 PMID:32112862

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 7

decreases expression

thymoquinone results in decreased expression of MMP7 mRNA

NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,586

G

matrix metallopeptidase 9

multiple interactions
decreases expression

pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; thymoquinone results in decreased expression of and results in decreased activity of MMP9 protein

PMID:27060453 PMID:32112862

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

myeloperoxidase

decreases activity

thymoquinone results in decreased activity of MPO protein

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

mechanistic target of rapamycin kinase

decreases phosphorylation

thymoquinone results in decreased phosphorylation of MTOR protein

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

myelocytomatosis oncogene

decreases expression

thymoquinone results in decreased expression of MYC mRNA

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

myeloid differentiation primary response gene 88

increases expression
multiple interactions

thymoquinone results in increased expression of MYD88 mRNA
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of MYD88 mRNA]

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

G

Nanog homeobox

decreases expression

thymoquinone results in decreased expression of NANOG protein

NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592

G

nestin

decreases expression

thymoquinone results in decreased expression of NES protein

NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

thymoquinone inhibits the reaction [Doxorubicin results in decreased activity of NFE2L2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; dorsomorphin inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; thymoquinone affects the localization of and results in increased activity of NFE2L2 protein

PMID:24355171 PMID:25268985

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions

thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of NFKB1 mRNA]

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nerve growth factor

multiple interactions

thymoquinone inhibits the reaction [nonylphenol results in increased expression of NGF protein]

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

nitric oxide synthase 1, neuronal

multiple interactions

thymoquinone inhibits the reaction [Isoproterenol results in decreased expression of NOS1 protein]

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 3, endothelial cell

multiple interactions

thymoquinone inhibits the reaction [Isoproterenol results in increased expression of NOS3 protein]

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

notch 1

multiple interactions

[cordycepin co-treated with thymoquinone] results in decreased expression of NOTCH1 protein

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

NADPH oxidase 4

multiple interactions

thymoquinone inhibits the reaction [Doxorubicin results in increased expression of NOX4 protein]

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

natriuretic peptide type A

multiple interactions

thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPA protein]

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

natriuretic peptide type B

multiple interactions

thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPB protein modified form]

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

poly (ADP-ribose) polymerase family, member 1

increases expression
increases cleavage
multiple interactions

thymoquinone results in increased expression of PARP1 protein modified form
thymoquinone results in increased cleavage of PARP1 protein
4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of PARP1 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased cleavage of PARP1 protein]

PMID:29981725 PMID:31298468 PMID:31433961 PMID:34627931

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

proliferating cell nuclear antigen

multiple interactions

thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of PCNA mRNA]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein]

PMID:29923357 PMID:36193556

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

POU domain, class 5, transcription factor 1

decreases expression

thymoquinone results in decreased expression of POU5F1 protein

NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669

G

peroxisome proliferator activated receptor gamma

multiple interactions
increases expression

PRKAA1 protein promotes the reaction [thymoquinone results in increased expression of PPARG protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

protein kinase, AMP-activated, alpha 1 catalytic subunit

multiple interactions

PRKAA1 protein promotes the reaction [thymoquinone results in increased expression of PPARG protein]

NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380

G

phosphatase and tensin homolog

multiple interactions

thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of PTEN protein]

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[thymoquinone co-treated with Diclofenac] results in decreased expression of PTGS1 protein

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

RNA binding protein, fox-1 homolog (C. elegans) 3

multiple interactions

thymoquinone inhibits the reaction [nonylphenol results in decreased expression of RBFOX3 protein]

NCBI chr11:118,380,586...118,802,423
Ensembl chr11:118,380,588...118,802,423

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

thymoquinone inhibits the reaction [Bleomycin results in increased expression of RELA protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of RELA mRNA]

PMID:22982510 PMID:26645134

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

receptor (TNFRSF)-interacting serine-threonine kinase 1

multiple interactions

thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK1 protein]

NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130

G

receptor-interacting serine-threonine kinase 3

multiple interactions

thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK3 protein]

NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322

G

RAR-related orphan receptor gamma

increases expression

thymoquinone results in increased expression of RORC mRNA

NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583

G

sirtuin 1

multiple interactions

thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]
thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 mRNA]; thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 protein]
thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]

PMID:27688165 PMID:36506574

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

snail family zinc finger 1

decreases expression
multiple interactions

thymoquinone results in decreased expression of SNAI1 protein
pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of SNAI1 protein]

PMID:27060453 PMID:35774120

NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734

G

snail family zinc finger 2

decreases expression
multiple interactions

thymoquinone results in decreased expression of SNAI2 protein
thymoquinone promotes the reaction [cordycepin results in decreased expression of SNAI2 protein]

NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249

G

superoxide dismutase 1, soluble

multiple interactions

thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased activity of SOD1 protein]

PMID:28734741 PMID:36193556

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions

thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 mRNA]

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

superoxide dismutase 3, extracellular

multiple interactions

thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA]

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

Rous sarcoma oncogene

multiple interactions
decreases phosphorylation

Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of SRC protein]
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of SRC protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of SRC protein]

PMID:31433961 PMID:34605108

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of STAT3 protein]

PMID:31433961 PMID:34605108 PMID:34627931

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

signal transducer and activator of transcription 6

increases expression

thymoquinone results in increased expression of STAT6 mRNA

NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826

G

serine/threonine kinase 11

multiple interactions

thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein modified form]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein]
thymoquinone inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]

NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516

G

transforming growth factor, beta 1

multiple interactions

thymoquinone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein]

PMID:27375216 PMID:27688165

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

TIR domain containing adaptor molecule 1

increases expression
multiple interactions

thymoquinone results in increased expression of TICAM1 mRNA
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TICAM1 mRNA]

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

G

tissue inhibitor of metalloproteinase 1

multiple interactions
increases expression

pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein]
thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]

PMID:27060453 PMID:27688165 PMID:31935363

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

increases expression
multiple interactions

thymoquinone results in increased expression of TIMP2 protein
pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

toll-like receptor 2

increases expression
multiple interactions

thymoquinone results in increased expression of TLR2 mRNA
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR2 mRNA]

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

toll-like receptor 4

multiple interactions
increases expression

thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR4 mRNA]
thymoquinone results in increased expression of TLR4 mRNA

PMID:29405769 PMID:31935363

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

decreases expression
increases expression
multiple interactions

thymoquinone results in decreased expression of TNF mRNA; thymoquinone results in decreased expression of TNF protein
thymoquinone results in increased expression of TNF protein
thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [cyhalothrin results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Ethanol results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [Propylthiouracil results in increased expression of TNF protein]; thymoquinone inhibits the reaction [sodium arsenite results in increased expression of TNF protein]

PMID:20957680 PMID:22450443 PMID:25268985 PMID:26645134 PMID:29085585 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 10b

multiple interactions

[Benzo(a)pyrene co-treated with thymoquinone] results in increased expression of TNFRSF10A mRNA

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

tumor necrosis factor receptor superfamily, member 25

multiple interactions

thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF25 protein]

NCBI chr 4:152,199,985...152,204,568
Ensembl chr 4:152,200,391...152,204,576

G

troponin I, cardiac 3

multiple interactions

thymoquinone inhibits the reaction [Isoproterenol results in increased secretion of TNNI3 protein]

NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228

G

topoisomerase (DNA) II alpha

affects activity

thymoquinone affects the activity of TOP2A protein

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

transformation related protein 53

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of TP53 protein]
thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of TP53 protein]

PMID:21609759 PMID:31433961 PMID:34627931 PMID:36193556

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

twist basic helix-loop-helix transcription factor 1

multiple interactions
decreases expression

pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of TWIST1 protein]

PMID:27060453 PMID:35774120

NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828

G

vascular endothelial growth factor A

decreases expression
multiple interactions

thymoquinone results in decreased expression of VEGFA protein
Doxorubicin promotes the reaction [thymoquinone results in decreased expression of VEGFA protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of VEGFA protein]

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vimentin

decreases expression
multiple interactions

thymoquinone results in decreased expression of VIM protein
CTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; Lithium Chloride inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of VIM protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of VIM protein]

PMID:27060453 PMID:32112862

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

wingless-type MMTV integration site family, member 3A

decreases expression

thymoquinone results in decreased expression of WNT3A protein

NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578

G

X-linked inhibitor of apoptosis

multiple interactions

thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of XIAP protein]

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

zinc finger E-box binding homeobox 1

multiple interactions
decreases expression

thymoquinone promotes the reaction [cordycepin results in decreased expression of ZEB1 protein]
thymoquinone results in decreased expression of ZEB1 protein

NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467

ubiquinone-0

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase family 1, subfamily A1

decreases expression

ubiquinone-O results in decreased expression of ALDH1 protein

NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829

G

caspase 1

multiple interactions
decreases expression

ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]
ubiquinone-O results in decreased expression of CASP1 protein

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

CD24a antigen

increases expression

ubiquinone-O results in increased expression of CD24 protein

NCBI chr10:43,454,433...43,460,261
Ensembl chr10:43,454,280...43,460,261

G

CD44 antigen

decreases expression

ubiquinone-O results in decreased expression of CD44 protein

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

cadherin 1

increases expression

ubiquinone-O results in increased expression of CDH1 mRNA; ubiquinone-O results in increased expression of CDH1 protein

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 2

decreases expression

ubiquinone-O results in decreased expression of CDH2 mRNA; ubiquinone-O results in decreased expression of CDH2 protein

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

hypoxia inducible factor 1, alpha subunit

decreases expression

ubiquinone-O results in decreased expression of HIF1A protein

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

hexokinase 2

decreases expression

ubiquinone-O results in decreased expression of HK2 protein

NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435

G

interleukin 18

multiple interactions
decreases expression

ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]
ubiquinone-O results in decreased expression of IL18 protein

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 beta

decreases expression
multiple interactions

ubiquinone-O results in decreased expression of IL1B protein
ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

lactate dehydrogenase A

decreases expression

ubiquinone-O results in decreased expression of LDHA protein

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

matrix metallopeptidase 2

multiple interactions

ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP2 mRNA]

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

multiple interactions

ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP9 mRNA]

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

NLR family, pyrin domain containing 3

multiple interactions
decreases expression

ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]
ubiquinone-O results in decreased expression of NLRP3 protein

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

G

nitric oxide synthase 2, inducible

multiple interactions
decreases expression

ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NOS2 protein]
ubiquinone-O results in decreased expression of NOS2 protein

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

pyruvate dehydrogenase kinase, isoenzyme 1

decreases expression

ubiquinone-O results in decreased expression of PDK1 protein

NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202

G

pyruvate kinase, muscle

decreases expression

ubiquinone-O results in decreased expression of PKM protein

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

PYD and CARD domain containing

decreases expression

ubiquinone-O results in decreased expression of PYCARD protein

NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039

G

solute carrier family 2 (facilitated glucose transporter), member 1

decreases expression

ubiquinone-O results in decreased expression of SLC2A1 mRNA; ubiquinone-O results in decreased expression of SLC2A1 protein

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

toll-like receptor 4

decreases expression

ubiquinone-O results in decreased expression of TLR4 protein

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

ubiquinone-1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

N-ribosyldihydronicotinamide quinone reductase 2

multiple interactions

[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q1

NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426

ubiquinone-9

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium inwardly-rectifying channel, subfamily J, member 6

decreases abundance

KCNJ6 gene mutant form results in decreased abundance of ubiquinone 9

NCBI chr16:94,545,839...94,798,719
Ensembl chr16:94,549,495...94,798,560

ubiquinones

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminolevulinate, delta-, dehydratase

multiple interactions

Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

aldehyde dehydrogenase 2, mitochondrial

multiple interactions

ubiquinones decrease 4-hydroxynonenal-Aldh2 protein adduct formation; decrease acylation, nitrosylation, S-nitrosylation, and nitration of Aldh2 protein in mouse liver

RGD

NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887

G

caspase 3

multiple interactions

[Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]
Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein]

PMID:12880480 PMID:24732427 PMID:35866224

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

increases activity

Ubiquinone results in increased activity of CAT protein

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

coenzyme Q8A

increases chemical synthesis

COQ8A protein results in increased chemical synthesis of Ubiquinone

NCBI chr 1:179,992,803...180,023,585
Ensembl chr 1:179,992,803...180,027,167

G

C-X-C motif chemokine ligand 15

multiple interactions

[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of CXCL8 protein]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

dihydroorotate dehydrogenase

multiple interactions
increases metabolic processing

2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
DHODH protein results in increased metabolism of Ubiquinone
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]; Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; X 910279 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]

PMID:9802339 PMID:11248707

NCBI chr 8:110,319,876...110,335,330
Ensembl chr 8:110,317,975...110,335,305

G

glutamic pyruvic transaminase, soluble

multiple interactions

Ubiquinone inhibits the reaction [Dexamethasone results in increased activity of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

interleukin 1 beta

multiple interactions

[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions

[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

nitric oxide synthase 3, endothelial cell

multiple interactions

Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Ubiquinone inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3]

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

[Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

peroxisome proliferator activated receptor alpha

multiple interactions

PPARA protein affects the reaction [Diethylhexyl Phthalate affects the abundance of Ubiquinone]

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

tumor necrosis factor

multiple interactions

[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

X-ray repair complementing defective repair in Chinese hamster cells 1

decreases oxidation
decreases reduction

XRCC1 results in decreased oxidation of Ubiquinone
XRCC1 gene mutant form results in decreased reduction of Ubiquinone

NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22178
chemical entity	22208
group	22072
inorganic group	21029
oxo group	20172
organic oxo compound	20172
carbonyl compound	20172
ketone	17949
cyclic ketone	16379
quinone	8755
benzoquinones	782
(+)-formylanserinone B	0
(Heptadeca-8,11-dienyl)-3,6-dihydroxy-1,4-benzoquinone	0
1,2-benzoquinones +	2
1,4-benzoquinones +	779
2,5-Dihydroxy-3-pentadecyl-1,4-benzoquinone	0
2,5-Dimethoxy-6-methyl-3-tridecyl-1,4-benzoquinone	0
2,5-di-tert-Butyl-1,4-benzoquinone	0
2-(2′, 3′-dihydrosorbyl)-3,6-dimethyl-5-hydroxy-1,4-benzoquinone	0
2-(Heptadec-8-enyl)-3,6-dihydroxy-1,4-benzoquinone	0
2-(Heptadecyl)-3,6-dihydroxy-1,4-benzoquinone	0
2-Acetoxy-5methoxy-6-methyl-3-tridecyl-1,4-benzoquinone	0
2-Hydroxy-4-imino-2,5-cyclohexadienone	0
2-Methoxy-1,4-benzoquinone	0
2-O-Methylatromentin	0
2-amino-6-hydroxy-[1,4]-benzoquinone	0
2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione	0
2-hydroxy-5-methoxy-3-(3-oxobutan-2-yl)cyclohexa-2,5-diene-1,4-dione	0
2-hydroxy-6-pentadecylcyclohexa-2,5-diene-1,4-dione	0
2-methoxy-5-methyl-1,4-benzoquinone	0
3-acetonyl-2,6-dimethyl-5-hydroxy-1,4-benzoquinone	0
3-hydroxy-2,5-toluquinone	0
4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione	0
5-Ethoxysorgoleone 358	0
Adlupone	0
Anserinone A	0
Anserinone B	0
Betulinan A	0
Betulinan C	0
Bromochlorogentisylquinone A	0
Bromochlorogentisylquinone B	0
Chlorogentisylquinone	0
Floricolin B	0
Floricolin C	0
Floricolin P	0
Gilluone B	0
Grandiflorone	0
Hyaladione	0
Hydroxymethylanserinone B	0
Malbranicin	0
Mycenon	0
Oosporein	0
Oxosorbicillinol	0
Oxosorbicillinol (tautomer)	0
Phomaligadione A	0
Phomaligadione B	0
Phomaligol A	0
Phomaligol A1	0
Polyporic acid	1
Prehumulone	0
Quinolidomicin A1	0
Quinolidomicin B1	0
Smenospongiarine	0
Smenospongimine	0
Sorgoleone 358	0
Sorrentanone	0
T1801 B	0
T1801 D	0
Talaroenamine B	0
Thermophillin	0
Volucrisporin	0
ascocorynin anion(1-)	0
benzoquinone +	2
benzoquinoneacetic acid	0
hydroxybenzoquinone +	125
methyl geldanamycinate	0
polyporic acid anion(1-)	0
Path 2
Term	Annotations
CHEBI ontology	22178
subatomic particle	22170
composite particle	22170
hadron	22201
baryon	22170
nucleon	22170
atomic nucleus	22170
atom	22170
main group element atom	22104
p-block element atom	22104
carbon group element atom	21904
carbon atom	21859
organic molecular entity	21830
heteroorganic entity	21482
organochalcogen compound	20966
organooxygen compound	20806
carbonyl compound	20172
ketone	17949
cyclic ketone	16379
quinone	8755
benzoquinones	782
(+)-formylanserinone B	0
(Heptadeca-8,11-dienyl)-3,6-dihydroxy-1,4-benzoquinone	0
1,2-benzoquinones +	2
1,4-benzoquinones +	779
2,5-Dihydroxy-3-pentadecyl-1,4-benzoquinone	0
2,5-Dimethoxy-6-methyl-3-tridecyl-1,4-benzoquinone	0
2,5-di-tert-Butyl-1,4-benzoquinone	0
2-(2′, 3′-dihydrosorbyl)-3,6-dimethyl-5-hydroxy-1,4-benzoquinone	0
2-(Heptadec-8-enyl)-3,6-dihydroxy-1,4-benzoquinone	0
2-(Heptadecyl)-3,6-dihydroxy-1,4-benzoquinone	0
2-Acetoxy-5methoxy-6-methyl-3-tridecyl-1,4-benzoquinone	0
2-Hydroxy-4-imino-2,5-cyclohexadienone	0
2-Methoxy-1,4-benzoquinone	0
2-O-Methylatromentin	0
2-amino-6-hydroxy-[1,4]-benzoquinone	0
2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione	0
2-hydroxy-5-methoxy-3-(3-oxobutan-2-yl)cyclohexa-2,5-diene-1,4-dione	0
2-hydroxy-6-pentadecylcyclohexa-2,5-diene-1,4-dione	0
2-methoxy-5-methyl-1,4-benzoquinone	0
3-acetonyl-2,6-dimethyl-5-hydroxy-1,4-benzoquinone	0
3-hydroxy-2,5-toluquinone	0
4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione	0
5-Ethoxysorgoleone 358	0
Adlupone	0
Anserinone A	0
Anserinone B	0
Betulinan A	0
Betulinan C	0
Bromochlorogentisylquinone A	0
Bromochlorogentisylquinone B	0
Chlorogentisylquinone	0
Floricolin B	0
Floricolin C	0
Floricolin P	0
Gilluone B	0
Grandiflorone	0
Hyaladione	0
Hydroxymethylanserinone B	0
Malbranicin	0
Mycenon	0
Oosporein	0
Oxosorbicillinol	0
Oxosorbicillinol (tautomer)	0
Phomaligadione A	0
Phomaligadione B	0
Phomaligol A	0
Phomaligol A1	0
Polyporic acid	1
Prehumulone	0
Quinolidomicin A1	0
Quinolidomicin B1	0
Smenospongiarine	0
Smenospongimine	0
Sorgoleone 358	0
Sorrentanone	0
T1801 B	0
T1801 D	0
Talaroenamine B	0
Thermophillin	0
Volucrisporin	0
ascocorynin anion(1-)	0
benzoquinone +	2
benzoquinoneacetic acid	0
hydroxybenzoquinone +	125
methyl geldanamycinate	0
polyporic acid anion(1-)	0

paths to the root