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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzopyrrole
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Accession:CHEBI:22728 term browser browse the term
Synonyms:related_synonym: benzopyrroles


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3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein] CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G CASP3 caspase 3 multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA] CTD PMID:15089098 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:15089098 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Indomethacin affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Indomethacin results in increased expression of DDIT3 mRNA CTD PMID:18799549 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Indomethacin results in increased expression of HSPA5 mRNA CTD PMID:18799549 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions
EXP Melatonin results in increased expression of BCL2 mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP3 caspase 3 decreases expression EXP Melatonin results in decreased expression of CASP3 mRNA CTD PMID:31535366 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA] CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Melatonin results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G PLIN2 perilipin 2 multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein] CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,274
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein] CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Melatonin results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G TP53 tumor protein p53 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Melatonin results in decreased expression of TP53 mRNA
CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
panobinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC1 histone deacetylase 1 multiple interactions EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein] CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Serotonin results in increased expression of FOS mRNA; Serotonin results in increased expression of FOS protein
sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS protein]
CTD PMID:11426759 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN protein]
Serotonin results in increased expression of JUN mRNA; Serotonin results in increased expression of JUN protein
CTD PMID:11426759 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Serotonin results in increased phosphorylation of MAPK1 protein
sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK1 protein]
CTD PMID:11426759 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK3 protein] CTD PMID:11426759 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
skatole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases oxidation EXP CYP1A1 protein results in increased oxidation of Skatole CTD PMID:30599194 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G CYP2A19 cytochrome P450 family 2 subfamily A member 19 increases hydroxylation
multiple interactions
EXP CYP2A19 protein results in increased hydroxylation of Skatole
Skatole inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; Skatole inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]
CTD PMID:30599194 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases hydroxylation
EXP Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; Skatole inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]
CYP2E1 protein results in increased hydroxylation of Skatole
CTD PMID:30599194 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
G CYP2G2 cytochrome P450 family 2 subfamily G member 2 increases abundance
increases metabolic processing
EXP CYP2A6 gene polymorphism results in increased abundance of Skatole
CYP2A6 protein results in increased metabolism of Skatole
CTD PMID:10828259 PMID:15265071 NCBI chr 6:49,069,613...49,084,953 JBrowse link
sunitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 decreases expression EXP Sunitinib results in decreased expression of GJA1 protein CTD PMID:32877659 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,515...41,002,137
JBrowse link
G TNNT2 troponin T2, cardiac type decreases expression EXP Sunitinib results in decreased expression of TNNT2 protein CTD PMID:32877659 NCBI chr10:23,749,528...23,759,696
Ensembl chr10:23,749,335...23,763,396
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 903
    chemical entity 903
      atom 888
        nonmetal atom 847
          nitrogen atom 336
            nitrogen molecular entity 336
              organonitrogen compound 324
                organonitrogen heterocyclic compound 225
                  benzopyrrole 25
                    indoles + 25
                    isoindoles + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 903
    subatomic particle 888
      composite particle 888
        hadron 888
          baryon 888
            nucleon 888
              atomic nucleus 888
                atom 888
                  main group element atom 857
                    p-block element atom 854
                      carbon group element atom 830
                        carbon atom 829
                          organic molecular entity 829
                            organic molecule 745
                              organic cyclic compound 655
                                organic heterocyclic compound 367
                                  organic heteropolycyclic compound 262
                                    organic heterobicyclic compound 105
                                      benzopyrrole 25
                                        indoles + 25
                                        isoindoles + 0
paths to the root