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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aziridines
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Accession:CHEBI:22681 term browser browse the term
Synonyms:xref_mesh: MESH:D001388



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aziridines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Aziridines analog results in decreased expression of BCL2 protein CTD PMID:15174162 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; NR3C1 protein promotes the reaction [Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]
Aziridines analog results in decreased expression of IL6 protein
Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Aziridines analog results in decreased expression of IL6 mRNA
CTD PMID:16243974 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Aziridines analog binds to and affects the localization of NR3C1 protein
NR3C1 protein promotes the reaction [Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]
CTD PMID:16243974 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Aziridines analog inhibits the reaction [TNF protein results in increased activity of and results in increased localization of RELA protein] CTD PMID:16243974 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; NR3C1 protein promotes the reaction [Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]
Aziridines analog inhibits the reaction [TNF protein results in increased activity of and results in increased localization of RELA protein]; Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:16243974 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
2,5-bis(aziridin-1-yl)-1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]
ethylenimine quinone results in increased expression of CDKN1A mRNA; ethylenimine quinone results in increased expression of CDKN1A protein
CTD PMID:8943236 PMID:9343371 PMID:9586815 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
2-Methylaziridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hexb hexosaminidase subunit beta increases activity EXP propyleneimine results in increased activity of HEXB protein CTD PMID:3092401 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
diaziquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]
CTD PMID:8943236 PMID:9343371 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO diaziquone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity
multiple interactions
increases metabolic processing
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone
CTD PMID:2113030 PMID:9343371 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
Thiotepa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Thiotepa CTD PMID:11778547 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects response to substance ISO ALDH1A1 protein affects the susceptibility to Thiotepa CTD PMID:18854779 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Thiotepa CTD PMID:18854779 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Thiotepa CTD PMID:19470598 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Thiotepa results in increased expression of BAD protein CTD PMID:10822281 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 affects expression
increases expression
ISO Thiotepa affects the expression of BAK1 protein
Thiotepa results in increased expression of BAK1 protein
CTD PMID:10822281 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Thiotepa results in increased expression of BAX protein
Thiotepa results in increased expression of BAX mRNA; Thiotepa results in increased expression of BAX protein
Niacinamide inhibits the reaction [Thiotepa results in increased expression of BAX mRNA]; Niacinamide inhibits the reaction [Thiotepa results in increased expression of BAX protein]
CTD PMID:10822281 PMID:22164206 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein CTD PMID:4672170 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases cleavage
increases expression
ISO Thiotepa results in decreased expression of BCL2 protein
Thiotepa results in increased cleavage of BCL2 protein
Thiotepa results in increased expression of BCL2 protein
CTD PMID:10822281 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Thiotepa results in increased expression of BCL2L1 protein CTD PMID:10822281 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
Niacinamide inhibits the reaction [Thiotepa results in increased activity of CASP3 protein] CTD PMID:10822281 PMID:22164206 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd59 CD59 molecule decreases lipidation EXP Thiotepa results in decreased lipidation of CD59 protein CTD PMID:27931811 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases oxidation
EXP Clofibrate promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa]; Dexamethasone promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa]; isosafrole promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa]; Phenobarbital promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa] CTD PMID:2105156 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects response to substance
multiple interactions
decreases activity
affects export
ISO CYP2B6 protein affects the susceptibility to Thiotepa
Thiotepa inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]; Thiotepa inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Thiotepa results in decreased activity of CYP2B6 protein
CYP2B6 gene SNP affects the export of Thiotepa
CTD PMID:15769884 PMID:18611395 PMID:19076156 PMID:23777987 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects response to substance
affects export
ISO CYP3A4 protein affects the susceptibility to Thiotepa
CYP3A4 gene SNP affects the export of Thiotepa
CTD PMID:19076156 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects export
affects response to substance
ISO CYP3A5 gene SNP affects the export of Thiotepa
CYP3A5 protein affects the susceptibility to Thiotepa
CTD PMID:19076156 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dcn decorin multiple interactions ISO DCN protein inhibits the reaction [TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa]] CTD PMID:9509296 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects response to substance
multiple interactions
ISO ERBB2 protein affects the susceptibility to Thiotepa
ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin]
CTD PMID:10327070 PMID:16446318 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects response to substance
affects export
ISO GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]
GSTA1 protein affects the susceptibility to Thiotepa
GSTA1 gene SNP affects the export of Thiotepa
CTD PMID:7712478 PMID:19076156 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
increases metabolic processing
affects response to substance
affects export
multiple interactions
decreases response to substance
ISO GSTP1 gene polymorphism affects the metabolism of Thiotepa
GSTP1 protein results in increased metabolism of Thiotepa
GSTP1 gene affects the susceptibility to Thiotepa; GSTP1 protein affects the susceptibility to Thiotepa
GSTP1 gene SNP affects the export of Thiotepa
GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]; GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]
GSTP1 gene polymorphism results in decreased susceptibility to Thiotepa
CTD PMID:7712478 PMID:10334868 PMID:12360105 PMID:19076156 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP Thiotepa results in increased mutagenesis of HPRT gene CTD PMID:10069464 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases response to substance ISO OGG1 protein results in decreased susceptibility to Thiotepa CTD PMID:11181913 PMID:11431349 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP Niacinamide inhibits the reaction [Thiotepa results in increased cleavage of PARP1 protein] CTD PMID:22164206 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis
multiple interactions
EXP Thiotepa results in increased mutagenesis of PIGA
Thiotepa results in increased mutagenesis of and results in decreased activity of PIGA protein
CTD PMID:22923490 PMID:27931811 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO DCN protein inhibits the reaction [TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa]]; TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa] CTD PMID:9509296 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO Thiotepa results in increased expression of YWHAQ protein CTD PMID:10822281 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      atom 19794
        nonmetal atom 19681
          nitrogen atom 18762
            nitrogen molecular entity 18762
              organonitrogen compound 18540
                organonitrogen heterocyclic compound 17659
                  aziridines 35
                    2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                    2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                    2-Methylaziridine 1
                    N-(2-aminoethyl)-1-aziridine-ethanamine 0
                    Thiotepa 27
                    apholate 0
                    aziridine + 0
                    aziridine aldehyde + 0
                    diaziquone 3
                    ficellomycin 0
                    triaziquone 0
                    vinylaziridines + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  organic heteromonocyclic compound 17121
                                    aziridines 35
                                      2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                                      2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                                      2-Methylaziridine 1
                                      N-(2-aminoethyl)-1-aziridine-ethanamine 0
                                      Thiotepa 27
                                      apholate 0
                                      aziridine + 0
                                      aziridine aldehyde + 0
                                      diaziquone 3
                                      ficellomycin 0
                                      triaziquone 0
                                      vinylaziridines + 0
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