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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aziridines
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Accession:CHEBI:22681 term browser browse the term
Synonyms:xref_mesh: MESH:D001388


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aziridines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Aziridines analog results in decreased expression of BCL2 protein CTD PMID:15174162 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; NR3C1 protein promotes the reaction [Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]
Aziridines analog results in decreased expression of IL6 protein
Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Aziridines analog results in decreased expression of IL6 mRNA
CTD PMID:16243974 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Aziridines analog binds to and affects the localization of NR3C1 protein
NR3C1 protein promotes the reaction [Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]
CTD PMID:16243974 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Aziridines analog inhibits the reaction [TNF protein results in increased activity of and results in increased localization of RELA protein] CTD PMID:16243974 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; NR3C1 protein promotes the reaction [Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]
Aziridines analog inhibits the reaction [TNF protein results in increased activity of and results in increased localization of RELA protein]; Aziridines analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:16243974 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
2,5-bis(aziridin-1-yl)-1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]
ethylenimine quinone results in increased expression of CDKN1A mRNA; ethylenimine quinone results in increased expression of CDKN1A protein
CTD PMID:8943236 PMID:9343371 PMID:9586815 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
2-Methylaziridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hexb hexosaminidase subunit beta increases activity EXP propyleneimine results in increased activity of HEXB protein CTD PMID:3092401 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
diaziquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]
CTD PMID:8943236 PMID:9343371 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO diaziquone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity
multiple interactions
increases metabolic processing
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone
CTD PMID:2113030 PMID:9343371 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
Thiotepa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Thiotepa CTD PMID:11778547 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects response to substance ISO ALDH1A1 protein affects the susceptibility to Thiotepa CTD PMID:18854779 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Thiotepa CTD PMID:18854779 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Thiotepa CTD PMID:19470598 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Thiotepa results in increased expression of BAD protein CTD PMID:10822281 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 affects expression
increases expression
ISO Thiotepa affects the expression of BAK1 protein
Thiotepa results in increased expression of BAK1 protein
CTD PMID:10822281 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Thiotepa results in increased expression of BAX protein
Thiotepa results in increased expression of BAX mRNA; Thiotepa results in increased expression of BAX protein
Niacinamide inhibits the reaction [Thiotepa results in increased expression of BAX mRNA]; Niacinamide inhibits the reaction [Thiotepa results in increased expression of BAX protein]
CTD PMID:10822281 PMID:22164206 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein CTD PMID:4672170 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases cleavage
increases expression
ISO Thiotepa results in decreased expression of BCL2 protein
Thiotepa results in increased cleavage of BCL2 protein
Thiotepa results in increased expression of BCL2 protein
CTD PMID:10822281 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Thiotepa results in increased expression of BCL2L1 protein CTD PMID:10822281 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
Niacinamide inhibits the reaction [Thiotepa results in increased activity of CASP3 protein] CTD PMID:10822281 PMID:22164206 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cd59 CD59 molecule decreases lipidation EXP Thiotepa results in decreased lipidation of CD59 protein CTD PMID:27931811 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases oxidation
EXP Clofibrate promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa]; Dexamethasone promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa]; isosafrole promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa]; Phenobarbital promotes the reaction [CYP2B1 protein results in increased oxidation of Thiotepa] CTD PMID:2105156 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects response to substance
multiple interactions
decreases activity
affects export
ISO CYP2B6 protein affects the susceptibility to Thiotepa
Thiotepa inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]; Thiotepa inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Thiotepa results in decreased activity of CYP2B6 protein
CYP2B6 gene SNP affects the export of Thiotepa
CTD PMID:15769884 PMID:18611395 PMID:19076156 PMID:23777987 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects export
affects response to substance
ISO CYP3A5 gene SNP affects the export of Thiotepa
CYP3A5 protein affects the susceptibility to Thiotepa
CTD PMID:19076156 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dcn decorin multiple interactions ISO DCN protein inhibits the reaction [TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa]] CTD PMID:9509296 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects response to substance
multiple interactions
ISO ERBB2 protein affects the susceptibility to Thiotepa
ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin]
CTD PMID:10327070 PMID:16446318 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects response to substance
affects export
ISO GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]
GSTA1 protein affects the susceptibility to Thiotepa
GSTA1 gene SNP affects the export of Thiotepa
CTD PMID:7712478 PMID:19076156 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
increases metabolic processing
affects response to substance
affects export
multiple interactions
decreases response to substance
ISO GSTP1 gene polymorphism affects the metabolism of Thiotepa
GSTP1 protein results in increased metabolism of Thiotepa
GSTP1 gene affects the susceptibility to Thiotepa; GSTP1 protein affects the susceptibility to Thiotepa
GSTP1 gene SNP affects the export of Thiotepa
GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]; GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]
GSTP1 gene polymorphism results in decreased susceptibility to Thiotepa
CTD PMID:7712478 PMID:10334868 PMID:12360105 PMID:19076156 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP Thiotepa results in increased mutagenesis of HPRT gene CTD PMID:10069464 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases response to substance ISO OGG1 protein results in decreased susceptibility to Thiotepa CTD PMID:11181913 PMID:11431349 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP Niacinamide inhibits the reaction [Thiotepa results in increased cleavage of PARP1 protein] CTD PMID:22164206 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis
multiple interactions
EXP Thiotepa results in increased mutagenesis of PIGA
Thiotepa results in increased mutagenesis of and results in decreased activity of PIGA protein
CTD PMID:22923490 PMID:27931811 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO DCN protein inhibits the reaction [TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa]]; TGFB1 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Cisplatin co-treated with Melphalan co-treated with Thiotepa] CTD PMID:9509296 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO Thiotepa results in increased expression of YWHAQ protein CTD PMID:10822281 NCBI chr 6:43,463,294...43,493,816
Ensembl chr 6:43,463,294...43,493,816
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18335
                organonitrogen heterocyclic compound 17481
                  aziridines 34
                    2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                    2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                    2-Methylaziridine 1
                    N-(2-aminoethyl)-1-aziridine-ethanamine 0
                    Thiotepa 26
                    aziridine + 0
                    aziridine aldehyde + 0
                    diaziquone 3
                    ficellomycin 0
                    triaziquone 0
                    vinylaziridines + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteromonocyclic compound 16467
                                    aziridines 34
                                      2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                                      2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                                      2-Methylaziridine 1
                                      N-(2-aminoethyl)-1-aziridine-ethanamine 0
                                      Thiotepa 26
                                      aziridine + 0
                                      aziridine aldehyde + 0
                                      diaziquone 3
                                      ficellomycin 0
                                      triaziquone 0
                                      vinylaziridines + 0
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