azide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	azide	go back to main search page
Accession:	CHEBI:22680	browse the term
Definition:	Any nitrogen molecular entity containing the group -N3.
Synonyms:	related_synonym:	azides
	alt_id:	MESH:D001386
	xref_mesh:	MESH:D001386

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Rat (523) Mouse (538) Human (541) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (523)

azide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

affects localization
multiple interactions

Azides affects the localization of AIFM1 protein
DNM1L protein promotes the reaction [Azides affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

BCL2 associated X, apoptosis regulator

affects localization
increases activity
multiple interactions

Azides affects the localization of BAX protein
Azides results in increased activity of BAX protein
BCL2 protein inhibits the reaction [Azides affects the localization of BAX protein]; BCL2 protein inhibits the reaction [Azides results in increased activity of BAX protein]; DNM1L protein promotes the reaction [Azides results in increased activity of BAX protein]; MFN1 protein inhibits the reaction [Azides results in increased activity of BAX protein]; MFN2 protein inhibits the reaction [Azides results in increased activity of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases response to substance

BCL2 protein inhibits the reaction [Azides affects the localization of BAX protein]; BCL2 protein inhibits the reaction [Azides results in increased activity of BAX protein]
BCL2 protein results in decreased susceptibility to Azides

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

dynamin 1-like

multiple interactions
increases response to substance

DNM1L protein promotes the reaction [Azides results in increased activity of BAX protein]
DNM1L protein results in increased susceptibility to Azides
DNM1L protein promotes the reaction [Azides affects the localization of AIFM1 protein]; DNM1L protein promotes the reaction [Azides results in increased activity of BAX protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

mitofusin 1

multiple interactions
decreases response to substance

MFN1 protein inhibits the reaction [Azides results in increased activity of BAX protein]
MFN1 protein results in decreased susceptibility to Azides

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

mitofusin 2

multiple interactions
decreases response to substance

MFN2 protein inhibits the reaction [Azides results in increased activity of BAX protein]
MFN2 protein results in decreased susceptibility to Azides

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

solute carrier family 2 member 1

increases activity
multiple interactions

Azides results in increased activity of SLC2A1 protein
Calcium deficiency inhibits the reaction [Azides results in increased activity of SLC2A1 protein]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 5 member 6

multiple interactions

Azides inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]

NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712

G

superoxide dismutase 1

multiple interactions

Azides promotes the reaction [Copper binds to SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

1-(2-(diphenylmethoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 6 member 3

affects binding

1-(2-(diphenylmethoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine binds to Slc6a3 protein

RGD

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

4-[2-(diphenylmethoxy)ethyl]-1-[(4-azidophenyl)-methyl]-piperidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 6 member 3

affects binding

4-[2-(diphenylmethoxy)ethyl]-1-[(4-azidophenyl)-methyl]-piperidine binds to Slc6a3 protein

RGD

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

zidovudine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 3

increases expression

Zidovudine results in increased expression of ABCA3 mRNA

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily A member 7

decreases expression
increases expression

Zidovudine results in decreased expression of ABCA7 mRNA
Zidovudine results in increased expression of ABCA7 mRNA

NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425

G

ATP binding cassette subfamily B member 11

decreases expression

Zidovudine results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression

Zidovudine results in increased expression of ABCB1 mRNA; Zidovudine results in increased expression of ABCB1 protein

PMID:9148857 PMID:15456083 PMID:18310046 PMID:24292225

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 9

increases expression

Zidovudine results in increased expression of ABCB9 mRNA

NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931

G

ATP binding cassette subfamily C member 1

increases expression

Zidovudine results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 10

increases expression

Zidovudine results in increased expression of ABCC10 mRNA

NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178

G

ATP binding cassette subfamily C member 3

increases expression
decreases expression

Zidovudine results in increased expression of ABCC3 mRNA
Zidovudine results in decreased expression of ABCC3 mRNA

PMID:24292225 PMID:27765674

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

affects abundance
increases expression
increases export

ABCC4 protein affects the abundance of Zidovudine
Zidovudine results in increased expression of ABCC4 mRNA
ABCC4 protein results in increased export of Zidovudine

PMID:15456083 PMID:18364470 PMID:18535159

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

increases export
increases expression

ABCC5 protein results in increased export of Zidovudine
Zidovudine results in increased expression of ABCC5 mRNA

PMID:15456083 PMID:18535159 PMID:24292225

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily C member 6

increases expression

Zidovudine results in increased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily D member 1

increases expression

Zidovudine results in increased expression of ABCD1 mRNA

NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115

G

ATP binding cassette subfamily F member 2

increases expression

Zidovudine results in increased expression of ABCF2 mRNA

NCBI chr 4:10,594,802...10,607,620
Ensembl chr 4:10,594,907...10,607,606

G

ATP binding cassette subfamily F member 3

increases expression

Zidovudine results in increased expression of ABCF3 mRNA

NCBI chr11:80,340,476...80,352,211
Ensembl chr11:80,339,977...80,352,211

G

ATP binding cassette subfamily G member 2

multiple interactions
increases expression
decreases expression
increases export
decreases export

3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Nelfinavir inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; pluronic block copolymer p85 inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]
Zidovudine results in increased expression of ABCG2 protein
Zidovudine results in decreased expression of ABCG2 mRNA
Zidovudine results in increased expression of ABCG2 mRNA

PMID:17437964 PMID:19056916 PMID:24292225 PMID:27765674 PMID:28705594 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 8

decreases expression

Zidovudine results in decreased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

acetyl-CoA carboxylase alpha

affects expression

Zidovudine affects the expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetyl-CoA carboxylase beta

affects expression

Zidovudine affects the expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

acyl-CoA dehydrogenase, short/branched chain

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA

NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379

G

acyl-CoA synthetase long-chain family member 6

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA

NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757

G

adenosine deaminase

increases expression

Zidovudine results in increased expression of ADA protein

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions

Zidovudine results in decreased expression of ADIPOQ protein
Zidovudine results in decreased expression of ADIPOQ mRNA; Zidovudine results in decreased expression of ADIPOQ protein
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA

PMID:15865214 PMID:16931933 PMID:17503663 PMID:17668557

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

AE binding protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of AEBP1 mRNA

NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877

G

actin filament associated protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA

NCBI chr14:74,743,322...74,856,300
Ensembl chr14:74,743,320...74,856,263

G

1-acylglycerol-3-phosphate O-acyltransferase 3

multiple interactions
increases expression

[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]
Zidovudine results in increased expression of AGPAT3 mRNA

NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358

G

AKT serine/threonine kinase 1

increases phosphorylation

Zidovudine results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

affects binding

Zidovudine binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

apolipoprotein A5

decreases expression
multiple interactions

Zidovudine results in decreased expression of APOA5 mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

adenine phosphoribosyl transferase

increases mutagenesis

Zidovudine results in increased mutagenesis of APRT gene

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 9

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA

PMID:18313992 PMID:20370541

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

cAMP regulated phosphoprotein 21

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNA

NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297

G

acid sensing ion channel subunit 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

G

argininosuccinate lyase

multiple interactions
increases activity

[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]
Zidovudine results in increased activity of ASL protein

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATP synthase F1 subunit gamma

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5F1C mRNA

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATP synthase F1 subunit delta

decreases expression

Zidovudine results in decreased expression of ATP5F1D mRNA

NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929

G

ATP synthase membrane subunit c locus 3

increases expression
multiple interactions

Zidovudine results in increased expression of ATP5MC3 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5MC3 mRNA

PMID:16894629 PMID:18313992

NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279

G

ATP synthase membrane subunit e

increases expression

Zidovudine results in increased expression of ATP5ME mRNA

NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase membrane subunit f

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5MF mRNA

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

ATP synthase membrane subunit G

increases expression

Zidovudine results in increased expression of ATP5MG mRNA

NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Zidovudine results in increased expression of ATP5PB mRNA

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATP synthase peripheral stalk subunit d

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PD mRNA

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATP synthase peripheral stalk subunit F6

increases expression
multiple interactions

Zidovudine results in increased expression of ATP5PF mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PF mRNA

PMID:16894629 PMID:18313992

NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119

G

ATP synthase peripheral stalk subunit OSCP

increases expression
multiple interactions

Zidovudine results in increased expression of ATP5PO mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5PO mRNA

PMID:16894629 PMID:18313992

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase phospholipid transporting 8B1

decreases expression

Zidovudine results in decreased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

BCL2, apoptosis regulator

affects response to substance
increases expression
multiple interactions
decreases expression

BCL2 protein affects the susceptibility to Zidovudine
Zidovudine results in increased expression of BCL2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of BCL2 mRNA
Drugs, Chinese Herbal promotes the reaction [Zidovudine results in decreased expression of BCL2 mRNA]

PMID:9850737 PMID:17696246 PMID:18313992 PMID:29594326

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2 interacting protein 3 like

increases expression

Zidovudine results in increased expression of BNIP3L protein

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

bone marrow stromal cell antigen 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

BTG anti-proliferation factor 2

increases expression

Zidovudine results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

complement C1r

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA

NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484

G

complement C3a receptor 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of C3AR1 mRNA

PMID:16931933 PMID:20370541

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

G

cysteinyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

[Acrolein co-treated with Zidovudine] results in increased cleavage of CASP3 protein; Drugs, Chinese Herbal promotes the reaction [Zidovudine results in increased expression of CASP3 mRNA]
Zidovudine results in increased cleavage of CASP3 protein
Zidovudine results in increased expression of CASP3 protein
Zidovudine results in increased activity of CASP3 protein
2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; glutapyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; tauropyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]

PMID:16601281 PMID:17696246 PMID:17943461 PMID:18801031 PMID:27238871

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage
multiple interactions

Zidovudine results in increased cleavage of CASP8 protein
Acrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein]; Zidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

decreases response to substance
multiple interactions
decreases activity

CAT protein results in decreased susceptibility to Zidovudine
Silybin inhibits the reaction [Zidovudine results in decreased activity of CAT protein]

PMID:19398959 PMID:25586000

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression

Zidovudine results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A2

multiple interactions
decreases expression

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNA2 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CCNA2 mRNA
Zidovudine results in decreased expression of CCNA2 mRNA

PMID:15784690 PMID:20370541

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin C

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of CCND1 mRNA
Zidovudine results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA
Zidovudine results in decreased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E2

decreases expression
multiple interactions

Zidovudine results in decreased expression of CCNE2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin L2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA

NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882

G

C-C motif chemokine receptor 5

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD36 molecule

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD44 molecule

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD83 molecule

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

cell division cycle 25A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle associated 8

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cyclin-dependent kinase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 7

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
affects expression
decreases expression

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1A mRNA
Zidovudine affects the expression of CDKN1A protein
Zidovudine results in decreased expression of CDKN1A mRNA

PMID:15784690 PMID:18389896

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2A

affects expression
increases expression

Zidovudine affects the expression of CDKN2A protein
Zidovudine results in increased expression of CDKN2A mRNA; Zidovudine results in increased expression of CDKN2A protein

PMID:16797627 PMID:18389896

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2C

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

CCAAT/enhancer binding protein alpha

decreases expression

Zidovudine results in decreased expression of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

complement factor D

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

checkpoint kinase 1

increases phosphorylation
decreases expression

Zidovudine results in increased phosphorylation of CHEK1 protein
Zidovudine results in decreased expression of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

decreases expression
increases phosphorylation

Zidovudine results in decreased expression of CHEK2 protein
Zidovudine results in increased phosphorylation of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

chimerin 1

decreases expression

Zidovudine results in decreased expression of CHN1 mRNA

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

cell death-inducing DFFA-like effector c

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

chloride voltage-gated channel 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CLCN3 mRNA

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

catechol-O-methyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

cytochrome c oxidase copper chaperone COX11

decreases expression

Zidovudine results in decreased expression of COX11 mRNA

NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322

G

cytochrome c oxidase assembly homolog COX15

decreases expression

Zidovudine results in decreased expression of COX15 mRNA

NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261

G

cytochrome c oxidase subunit 5A

decreases expression
multiple interactions

Zidovudine results in decreased expression of COX5A protein
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX5A mRNA

PMID:7807166 PMID:18313992

NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781

G

cytochrome c oxidase subunit 5B

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNA
Zidovudine results in decreased expression of COX5B protein

PMID:7807166 PMID:18313992

NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052

G

cytochrome c oxidase subunit 6A1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of COX6A1 mRNA

NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041

G

cytochrome c oxidase subunit 6C

decreases expression
multiple interactions

Zidovudine results in decreased expression of COX6C protein
[Zidovudine co-treated with Lamivudine] results in increased expression of COX6C mRNA

PMID:7807166 PMID:18313992

NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963

G

cytochrome c oxidase subunit 7A1

decreases expression

Zidovudine results in decreased expression of COX7A1 protein

NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151

G

cytochrome c oxidase subunit 7A2

increases expression

Zidovudine results in increased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 7B

increases expression
decreases expression

Zidovudine results in increased expression of COX7B mRNA
Zidovudine results in decreased expression of COX7B protein

PMID:7807166 PMID:16894629

NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732

G

cytochrome c oxidase subunit 7C

decreases expression
multiple interactions

Zidovudine results in decreased expression of COX7C protein
[Zidovudine co-treated with Lamivudine] results in increased expression of COX7C mRNA

PMID:7807166 PMID:18313992

NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760

G

copine 5

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA

NCBI chr20:7,206,742...7,289,309
Ensembl chr20:7,206,742...7,288,883

G

carnitine palmitoyltransferase 1A

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNA
Zidovudine results in increased expression of CPT1A mRNA

PMID:14576092 PMID:18313992

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine O-acetyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

citrate synthase

affects expression
decreases expression

Zidovudine affects the expression of CS mRNA
Zidovudine results in decreased expression of CS protein

PMID:1892364 PMID:20032539

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

colony stimulating factor 2

multiple interactions

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]; [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 2 receptor subunit alpha

multiple interactions
decreases expression

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]

NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128

G

chondroitin sulfate N-acetylgalactosaminyltransferase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNA

NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319

G

cullin 7

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNA

NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741

G

cytochrome b5 type A

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA
Zidovudine results in decreased expression of CYB5A mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]

PMID:18313992 PMID:28619387

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

decorin

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of DDIT3 mRNA
Zidovudine results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

discoidin domain receptor tyrosine kinase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

dihydrofolate reductase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

diablo, IAP-binding mitochondrial protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

dihydrolipoamide S-succinyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

G

dystrophin

affects localization

Zidovudine affects the localization of DMD protein

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNA

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

dynamin 1-like

multiple interactions
affects localization

[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein
Zidovudine affects the localization of DNM1L protein

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

deltex E3 ubiquitin ligase 3L

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of DTX3L mRNA

NCBI chr11:64,814,926...64,824,539
Ensembl chr11:64,814,926...64,824,538

G

deoxythymidylate kinase

multiple interactions
affects response to substance

[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein; DTYMK gene mutant form results in increased phosphorylation of and results in increased susceptibility to Zidovudine

PMID:17375075 PMID:28683400

NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870

G

dual specificity phosphatase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNA

NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962

G

enoyl-CoA hydratase, short chain 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

enoyl-CoA delta isomerase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

endothelin 1

multiple interactions
increases secretion

coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

early growth response 1

multiple interactions

[Zidovudine co-treated with Arsenic Trioxide] results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ets homologous factor

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA

NCBI chr 3:89,639,845...89,680,061
Ensembl chr 3:89,641,833...89,679,997

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Zidovudine results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ELOVL fatty acid elongase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of ELOVL3 mRNA

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

G

erythropoietin

increases expression
multiple interactions

Zidovudine results in increased expression of EPO protein
EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]; Zidovudine promotes the reaction [Staphylococcal Protein A results in increased expression of EPO protein]

PMID:1549625 PMID:1889487 PMID:3422548 PMID:7646543 PMID:9735323

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

erythropoietin receptor

multiple interactions
decreases expression

EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]
Zidovudine results in decreased expression of EPOR mRNA; Zidovudine results in decreased expression of EPOR protein

PMID:1417927 PMID:7646543

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

epithelial stromal interaction 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of EPSTI1 mRNA

NCBI chr15:53,283,964...53,382,192
Ensembl chr15:53,284,216...53,382,191

G

estrogen receptor 1

affects localization

Zidovudine affects the localization of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ETS variant transcription factor 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

fatty acid binding protein 4

affects expression

Zidovudine affects the expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid desaturase 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

Fas apoptotic inhibitory molecule

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

Fas cell surface death receptor

increases expression

Zidovudine results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression
multiple interactions

Zidovudine results in increased expression of FASLG protein
Zidovudine results in increased expression of FASLG mRNA
Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]
[Acrolein co-treated with Zidovudine] results in increased expression of FASLG protein; Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]

PMID:17943461 PMID:27238871

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

affects expression
decreases expression
multiple interactions

Zidovudine affects the expression of FASN mRNA
Zidovudine results in decreased expression of FASN protein
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNA

PMID:11741158 PMID:15722030 PMID:20032539

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

Fc gamma receptor 1A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of FCGR1A mRNA

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

ferredoxin reductase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA

NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658

G

fibrinogen-like 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of FGL2 mRNA

NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207

G

fumarate hydratase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of FH1 mRNA

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box P3

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

G0/G1switch 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucosidase, alpha; neutral C

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNA

NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241

G

glycyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of GARS1 mRNA

NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609

G

growth arrest-specific 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of GAS1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GAS1 mRNA

PMID:15784690 PMID:20370541

NCBI chr17:4,482,168...4,485,153

G

GATA binding protein 1

decreases activity
decreases expression

Zidovudine results in decreased activity of GATA1 protein
Zidovudine results in decreased expression of GATA1 mRNA

PMID:8599995 PMID:10651068

NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530

G

guanylate binding protein 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNA

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

G

glutamic--pyruvic transaminase

multiple interactions
affects activity
increases activity

Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; Silybin affects the reaction [Zidovudine affects the activity of GPT protein]; Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]

PMID:25586000 PMID:28619387

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

growth factor receptor bound protein 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of GRB7 mRNA

NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052

G

grainyhead-like transcription factor 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA

NCBI chr 7:68,400,287...68,530,269
Ensembl chr 7:68,400,477...68,530,258

G

general transcription factor IIH subunit 1

increases expression

Zidovudine results in increased expression of GTF2H1 mRNA; Zidovudine results in increased expression of GTF2H1 protein

NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of GUCY1B1 mRNA

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

glycophorin A

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA gene

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

G

H2A.X variant histone

increases phosphorylation

Zidovudine results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

affects expression

Zidovudine affects the expression of H6PD mRNA

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hydroxyacyl-CoA dehydrogenase

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNA

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

HCLS1 associated protein X-1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA

NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714

G

hemoglobin subunit beta

decreases expression

Zidovudine results in decreased expression of HBB mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

G

high density lipoprotein binding protein

decreases expression

Zidovudine results in decreased expression of HDLBP mRNA

NCBI chr 9:93,948,099...94,018,040
Ensembl chr 9:93,949,913...94,018,048

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

histone cluster 1 H4 family member B

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

increases expression

Zidovudine results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis

Zidovudine results in increased mutagenesis of HPRT1 exon

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

multiple interactions

[Zidovudine co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

harakiri, BCL2 interacting protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

hydroxysteroid 11-beta dehydrogenase 1

affects expression

Zidovudine affects the expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B3 mRNA

NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033

G

heat shock protein family D (Hsp60) member 1

affects expression

Zidovudine affects the expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of IDH3G mRNA

NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171

G

interferon, alpha-inducible protein 27

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon-induced protein 35

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

G

interferon-induced protein 44-like

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon induced transmembrane protein 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon, alpha 1

multiple interactions
affects expression

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 protein; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL4 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in increased expression of IL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CD1C mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CYP1B1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GAS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GRB7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of H4C3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of LGALS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of MVD mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PGR mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PIERCE1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB17 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB3B mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RASSF7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of SAPCD2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRIQK mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of WDR62 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNA2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DDX60L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DNA2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DTX3L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of EPSTI1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ERV3-2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of FCGR1A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of FGL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI27 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI35 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIH1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFITM1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ISG15 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of JAK2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LAMP3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LAP3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LGALS9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRA1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LY6E mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MNDA mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MOV10 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MT1G mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MT2A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MX1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MX2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NEXN mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NT5C3A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NUB1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NUF2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PARP9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PCNA mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PF4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PIK3AP1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PLSCR1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RGS6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RNF213 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RPT4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RSAD2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SAMD9L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SCIMP mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SERPING1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SHFL mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC24A4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC7A7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF10 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF13B mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNNI2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TRIM22 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TRMT44 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TTC21A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TXLNGY mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ZNF629 mRNA; IRF4 protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]; REL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]
Zidovudine affects the expression of IFNA1 protein

PMID:9612607 PMID:17138822 PMID:20370541 PMID:23962110

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

affects expression
multiple interactions

Zidovudine affects the expression of IFNG protein
[Arsenic co-treated with Zidovudine co-treated with IFNG protein] results in increased expression of IL2 mRNA

PMID:9612607 PMID:23962110

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

IKAROS family zinc finger 4

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of IKZF4 mRNA

NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341

G

interleukin 10

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

increases expression

Zidovudine results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Zidovudine results in increased expression of IL1B mRNA; Zidovudine results in increased expression of IL1B protein

PMID:9184656 PMID:17668557

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in increased expression of IL2 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNG protein] results in increased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 27 receptor subunit alpha

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA

NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938

G

interleukin 2 receptor subunit alpha

multiple interactions
decreases expression

Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]
Zidovudine results in decreased expression of IL2RA mRNA; Zidovudine results in decreased expression of IL2RA protein

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 3

multiple interactions

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]; [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]

PMID:7646543 PMID:12084393

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 3 receptor subunit alpha

multiple interactions
decreases expression

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]

NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484

G

interleukin 4

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression

Zidovudine results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inositol polyphosphate-5-phosphatase E

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of INPP5E mRNA

NCBI chr 3:9,216,776...9,229,539
Ensembl chr 3:9,216,776...9,229,450

G

interferon regulatory factor 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNA

NCBI chr16:45,439,215...45,550,054
Ensembl chr16:45,439,225...45,550,024

G

interferon regulatory factor 4

multiple interactions

IRF4 protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

G

interferon regulatory factor 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

ISG15 ubiquitin-like modifier

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

inter-alpha-trypsin inhibitor heavy chain 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNA

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

Janus kinase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

potassium voltage-gated channel modifier subfamily G member 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KCNG1 mRNA

NCBI chr 3:156,960,717...156,992,877
Ensembl chr 3:156,973,156...156,992,635

G

kinesin family member C2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of KIFC2 mRNA

NCBI chr 7:108,380,634...108,388,364
Ensembl chr 7:108,376,011...108,388,484

G

KLF transcription factor 4

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kelch-like family member 28

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of KLHL28 mRNA

NCBI chr 6:82,987,360...83,018,971
Ensembl chr 6:82,990,945...83,016,164

G

KRAS proto-oncogene, GTPase

increases mutagenesis

Zidovudine results in increased mutagenesis of KRAS gene

NCBI chr 4:178,185,418...178,218,484

G

keratin 7

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KRT7 mRNA

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

kynureninase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

laminin subunit beta 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of LAMB3 mRNA

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405

G

laminin subunit gamma 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of LAMC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

lysosomal-associated membrane protein 2

decreases expression

Zidovudine results in decreased expression of LAMP2 protein

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

lysosomal-associated membrane protein 3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LAMP3 mRNA

NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784

G

leucine aminopeptidase 3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LAP3 mRNA

NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359

G

lymphoid enhancer binding factor 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

leptin

decreases expression
multiple interactions

Zidovudine results in decreased expression of LEP protein
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA

PMID:16931933 PMID:17668557

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

galectin 9

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LGALS9 mRNA

NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045

G

leukocyte immunoglobulin like receptor B4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB4 mRNA

NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660

G

lipase E, hormone sensitive type

affects expression

Zidovudine affects the expression of LIPE mRNA

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

G

lon peptidase 1, mitochondrial

affects expression

Zidovudine affects the expression of LONP1 protein

NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771

G

lipoprotein lipase

decreases expression
multiple interactions
affects expression

Zidovudine results in decreased expression of LPL mRNA
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNA
Zidovudine affects the expression of LPL mRNA

PMID:11741158 PMID:16894629 PMID:20032539

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

lymphocyte antigen 6 family member E

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LY6E mRNA

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

mitogen-activated protein kinase 8

increases phosphorylation

Zidovudine results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

methionyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MARS1 mRNA

NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495

G

MDM2 proto-oncogene

increases expression

Zidovudine results in increased expression of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 1

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNA
Zidovudine results in decreased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

mitochondrial fission factor

multiple interactions

[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein

NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039

G

mitofusin 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNA

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

mitofusin 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MFN2 mRNA

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

MGAT4 family, member C

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MGAT4C mRNA

NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571

G

matrix metallopeptidase 2

multiple interactions

Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

methylmalonyl-CoA mutase

affects expression
increases expression

Zidovudine affects the expression of MMUT mRNA mutant form; Zidovudine affects the expression of MMUT protein mutant form
Zidovudine results in increased expression of MMUT mRNA; Zidovudine results in increased expression of MMUT protein

PMID:19199343 PMID:19427250

NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046

G

myeloid cell nuclear differentiation antigen

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MNDA mRNA

NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201

G

Mov10 RNA helicase

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MOV10 mRNA

NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083

G

major histocompatibility complex, class I-related

affects expression

Zidovudine affects the expression of MR1 mRNA

NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970

G

melanocortin 2 receptor accessory protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNA

NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024

G

mitochondrially encoded ATP synthase membrane subunit 6

increases expression

Zidovudine results in increased expression of ATP6 mRNA

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

G

mitochondrially encoded cytochrome c oxidase I

increases expression
decreases expression
multiple interactions

Zidovudine results in increased expression of COX1 mRNA
Zidovudine results in decreased expression of COX1 protein
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA; Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein]

PMID:7528833 PMID:17526437 PMID:18163507 PMID:18313992 PMID:20032772 More...

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase II

decreases expression
multiple interactions
increases expression

Zidovudine results in decreased expression of COX2 protein
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX2 mRNA
Zidovudine results in increased expression of COX2 mRNA

PMID:7807166 PMID:10912924 PMID:16894629 PMID:18313992

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrially encoded cytochrome c oxidase III

affects expression
multiple interactions
decreases expression
increases expression

Zidovudine affects the expression of COX3 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of COX3 mRNA
Zidovudine results in decreased expression of COX3 mRNA
Zidovudine results in increased expression of COX3 mRNA

PMID:8828681 PMID:9799652 PMID:16894629 PMID:17526437 PMID:18313992 More...

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

mitochondrially encoded cytochrome b

affects expression
decreases expression
increases expression

Zidovudine affects the expression of CYTB mRNA
Zidovudine results in decreased expression of CYTB mRNA
Zidovudine results in increased expression of CYTB mRNA

PMID:1715447 PMID:7528833 PMID:20032539

NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

increases expression

Zidovudine results in increased expression of ND1 mRNA

NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

increases expression
multiple interactions

Zidovudine results in increased expression of ND2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ND2 mRNA

PMID:16894629 PMID:18313992

NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

increases expression
affects expression

Zidovudine results in increased expression of ND4 mRNA
Zidovudine affects the expression of ND4 mRNA

PMID:16894629 PMID:20032539

NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

increases expression
multiple interactions

Zidovudine results in increased expression of ND5 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ND5 mRNA

PMID:16894629 PMID:17526437 PMID:18313992

NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565

G

metallothionein 2A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

mechanistic target of rapamycin kinase

increases phosphorylation

Zidovudine results in increased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mevalonate diphosphate decarboxylase

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of MVD mRNA

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

G

MX dynamin like GTPase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MX dynamin like GTPase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

myosin heavy chain 7

increases expression

Zidovudine results in increased expression of MYH7 mRNA; Zidovudine results in increased expression of MYH7 protein

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myogenic differentiation 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MYOD1 mRNA

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

nucleosome assembly protein 1-like 5

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NAP1L5 mRNA

NCBI chr 4:88,022,670...88,024,988
Ensembl chr 4:88,022,569...88,024,654

G

N-acetyltransferase 2

decreases expression
multiple interactions

Zidovudine results in decreased expression of NAT2 mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

Ndufa4, mitochondrial complex associated

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFA4 mRNA

NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920

G

NADH:ubiquinone oxidoreductase subunit A6

increases expression

Zidovudine results in increased expression of NDUFA6 mRNA

NCBI chr 7:113,866,382...113,870,239
Ensembl chr 7:113,866,382...113,870,239

G

NADH:ubiquinone oxidoreductase subunit A9

increases expression

Zidovudine results in increased expression of NDUFA9 mRNA

NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018

G

NADH:ubiquinone oxidoreductase subunit AB1

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFAB1 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAB1 mRNA

PMID:16894629 PMID:18313992

NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099

G

NADH:ubiquinone oxidoreductase complex assembly factor 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAF1 mRNA

NCBI chr 3:106,639,025...106,650,549
Ensembl chr 3:106,639,851...106,650,212

G

NADH:ubiquinone oxidoreductase subunit B11

multiple interactions

Zidovudine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]

NCBI chr X:1,572,805...1,575,063
Ensembl chr X:1,572,785...1,575,062

G

NADH:ubiquinone oxidoreductase subunit B3

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFB3 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB3 mRNA

PMID:16894629 PMID:18313992

NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446

G

NADH:ubiquinone oxidoreductase subunit B5

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFB5 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB5 mRNA

PMID:16894629 PMID:18313992

NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589

G

NADH:ubiquinone oxidoreductase subunit B6

increases expression

Zidovudine results in increased expression of NDUFB6 mRNA

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

G

NADH:ubiquinone oxidoreductase subunit B9

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFB9 mRNA

NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009

G

NADH:ubiquinone oxidoreductase subunit C1

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFC1 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFC1 mRNA

PMID:16894629 PMID:18313992

NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874

G

NADH:ubiquinone oxidoreductase core subunit S1

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFS1 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFS1 mRNA

PMID:16894629 PMID:18313992

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

Zidovudine results in decreased expression of NDUFS2 mRNA

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

G

NADH:ubiquinone oxidoreductase subunit S5

increases expression

Zidovudine results in increased expression of NDUFS5 mRNA

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

NADH:ubiquinone oxidoreductase subunit S6

increases expression

Zidovudine results in increased expression of NDUFS6 mRNA

NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467

G

NADH:ubiquinone oxidoreductase core subunit V1

decreases expression

Zidovudine results in decreased expression of NDUFV1 mRNA

NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466

G

nexilin (F actin binding protein)

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NEXN mRNA

NCBI chr 2:241,186,783...241,218,315
Ensembl chr 2:241,186,790...241,218,342

G

nuclear factor, erythroid 2

decreases activity
decreases expression

Zidovudine results in decreased activity of NFE2 protein
Zidovudine results in decreased expression of NFE2 mRNA

NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108

G

NFE2 like bZIP transcription factor 2

increases expression

Zidovudine results in increased expression of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

niban apoptosis regulator 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NIBAN1 mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

nocturnin

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400

G

nitric oxide synthase 3

multiple interactions
decreases phosphorylation

coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide A

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA
Zidovudine results in increased expression of NPPA mRNA

PMID:10701688 PMID:11706060

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

NAD(P)H quinone dehydrogenase 1

increases expression

Zidovudine results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

affects expression

Zidovudine affects the expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear respiratory factor 1

increases expression

Zidovudine results in increased expression of NRF1 mRNA

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

5'-nucleotidase, cytosolic IIIA

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NT5C3A mRNA

NCBI chr 4:86,161,642...86,204,656
Ensembl chr 4:86,161,643...86,204,628

G

negative regulator of ubiquitin-like proteins 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NUB1 mRNA

NCBI chr 4:10,442,917...10,473,689
Ensembl chr 4:10,442,917...10,473,694

G

NUF2 component of NDC80 kinetochore complex

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NUF2 mRNA

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

nucleoporin 210

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NUP210 mRNA

NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874

G

nucleoredoxin-like 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NXNL2 mRNA

NCBI chr17:14,031,151...14,035,897
Ensembl chr17:14,031,153...14,036,189

G

2'-5' oligoadenylate synthetase 1A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

2'-5' oligoadenylate synthetase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS2 mRNA

NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371

G

2'-5'-oligoadenylate synthetase 3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNA

NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781

G

ornithine decarboxylase antizyme 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of OAZ3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of OAZ3 mRNA

NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399

G

O-linked N-acetylglucosamine (GlcNAc) transferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of OGT mRNA

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA
[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein

PMID:18313992 PMID:28683400

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

opioid related nociceptin receptor 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNA

NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920

G

poly (ADP-ribose) polymerase family, member 9

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PARP9 mRNA

NCBI chr11:64,780,977...64,814,995
Ensembl chr11:64,780,981...64,815,455

G

poly(rC) binding protein 4

increases expression

Zidovudine results in increased expression of PCBP4 mRNA

NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276

G

protocadherin related 15

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PCDH15 mRNA

NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNA

NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283

G

proliferating cell nuclear antigen

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

phosphatidylethanolamine binding protein 1

decreases expression

Zidovudine results in decreased expression of PEBP1 mRNA

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

platelet factor 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

post-GPI attachment to proteins 6

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of PGAP6 mRNA

NCBI chr10:15,138,918...15,148,431
Ensembl chr10:15,138,959...15,148,431

G

progesterone receptor

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

PHD finger protein 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of PHF6 mRNA

NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127

G

p53-induced death domain protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIDD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIDD1 mRNA

NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699

G

piercer of microtubule wall 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PIERCE1 mRNA

NCBI chr 3:11,797,031...11,801,568
Ensembl chr 3:11,797,031...11,801,568

G

phosphoinositide-3-kinase adaptor protein 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PIK3AP1 mRNA

NCBI chr 1:240,090,854...240,245,007
Ensembl chr 1:240,093,065...240,204,828

G

paired Ig-like receptor B

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB3 mRNA

NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666

G

piwi-like RNA-mediated gene silencing 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PIWIL2 mRNA

NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702

G

protein kinase, membrane associated tyrosine/threonine 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNA

NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995

G

phospholipid scramblase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PLSCR1 mRNA

NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692

G

polynucleotide kinase 3'-phosphatase

increases expression

Zidovudine results in increased expression of PNKP mRNA

NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920

G

cytochrome p450 oxidoreductase

decreases expression
multiple interactions

Zidovudine results in decreased expression of POR mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

porcupine O-acyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PPN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PPN mRNA

NCBI chr X:14,285,864...14,298,481
Ensembl chr X:14,285,871...14,298,481

G

POU class 5 homeobox 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor gamma

decreases expression

Zidovudine results in decreased expression of PPARG mRNA; Zidovudine results in decreased expression of PPARG protein

PMID:15722030 PMID:17926646

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PR/SET domain 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

phosphoserine aminotransferase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

prostaglandin-endoperoxide synthase 2

decreases expression

Zidovudine results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAB17, member RAS oncogene family

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB17 mRNA

NCBI chr 9:91,552,924...91,566,759
Ensembl chr 9:91,553,464...91,566,451

G

RAB3B, member RAS oncogene family

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB3B mRNA

NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401

G

Rab9 effector protein with kelch motifs

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of RABEPK mRNA

NCBI chr 3:18,061,299...18,083,191
Ensembl chr 3:18,061,574...18,083,191

G

Ras association domain family member 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RASSF7 mRNA

NCBI chr 1:196,319,600...196,323,787
Ensembl chr 1:196,320,902...196,323,770

G

RB transcriptional corepressor like 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL1 mRNA

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

RB transcriptional corepressor like 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL2 mRNA

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

receptor accessory protein 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of REEP6 mRNA

NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597

G

REL proto-oncogene, NF-kB subunit

multiple interactions

REL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases expression

2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of RELA protein]; glutapyrone inhibits the reaction [Zidovudine results in increased expression of RELA protein]; tauropyrone inhibits the reaction [Zidovudine results in increased expression of RELA protein]
Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]

PMID:18801031 PMID:27238871

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

regulator of G-protein signaling 6

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of RGS6 mRNA

NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753

G

receptor-interacting serine-threonine kinase 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

ring finger protein 151

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of RNF151 mRNA

NCBI chr10:13,742,682...13,747,192
Ensembl chr10:13,742,682...13,745,000

G

ring finger protein 213

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of RNF213 mRNA

NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918

G

replication protein A1

increases expression

Zidovudine results in increased expression of RPA1 mRNA

NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949

G

RPA interacting protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of RPAIN mRNA

NCBI chr10:55,692,410...55,699,910
Ensembl chr10:55,692,417...55,699,933

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

Zidovudine results in increased expression of RRM2B mRNA

NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633

G

radical S-adenosyl methionine domain containing 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class I, locus CE16

affects expression

Zidovudine affects the expression of HLA-A mRNA

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

G

S100 calcium binding protein A8

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

sterile alpha motif domain containing 9 like

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SAMD9L mRNA

NCBI chr 4:31,362,054...31,376,412
Ensembl chr 4:31,361,669...31,376,415

G

suppressor APC domain containing 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of SAPCD2 mRNA

NCBI chr 3:8,186,089...8,195,119
Ensembl chr 3:8,187,266...8,192,546

G

SLP adaptor and CSK interacting membrane protein

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SCIMP mRNA

NCBI chr10:55,507,646...55,527,764
Ensembl chr10:55,507,519...55,528,171

G

succinate dehydrogenase complex iron sulfur subunit B

decreases expression
multiple interactions

Zidovudine results in decreased expression of SDHB mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA

PMID:16894629 PMID:18313992

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

succinate dehydrogenase complex subunit D

increases expression

Zidovudine results in increased expression of SDHD mRNA

NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238

G

serine incorporator 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SERINC1 mRNA

NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691

G

serpin family G member 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SERPING1 mRNA

NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034

G

sideroflexin 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN1 mRNA

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

sideroflexin 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN2 mRNA

NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411
Ensembl chr 1:245,447,015...245,468,411

G

sideroflexin 4

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN4 mRNA

NCBI chr 1:259,976,480...259,998,778
Ensembl chr 1:259,976,481...259,998,754

G

sphingosine-1-phosphate phosphatase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SGPP1 mRNA

NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534

G

shiftless antiviral inhibitor of ribosomal frameshifting

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SHFL mRNA

NCBI chr 8:19,408,298...19,414,084
Ensembl chr 8:19,408,333...19,413,971

G

sialic acid binding Ig like lectin 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA

NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850

G

sirtuin 3

increases expression

Zidovudine results in increased expression of SIRT3 protein

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 10, member 3

increases expression

Zidovudine results in increased expression of SLC10A3 mRNA

NCBI chr X:152,154,757...152,158,563
Ensembl chr X:152,151,076...152,162,958

G

solute carrier family 12 member 3

decreases expression

Zidovudine results in decreased expression of SLC12A3 mRNA

NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091

G

solute carrier family 12 member 4

increases expression

Zidovudine results in increased expression of SLC12A4 mRNA

NCBI chr19:33,838,418...33,860,369
Ensembl chr19:33,838,419...33,860,331

G

solute carrier family 12, member 9

increases expression

Zidovudine results in increased expression of SLC12A9 mRNA

NCBI chr12:19,368,990...19,385,881
Ensembl chr12:19,369,004...19,385,877

G

solute carrier family 13 member 3

increases expression
decreases expression

Zidovudine results in increased expression of SLC13A3 mRNA
Zidovudine results in decreased expression of SLC13A3 mRNA

NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606

G

solute carrier family 13 member 5

decreases expression
increases expression

Zidovudine results in decreased expression of SLC13A5 mRNA
Zidovudine results in increased expression of SLC13A5 mRNA

NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945

G

solute carrier family 16 member 1

decreases expression

Zidovudine results in decreased expression of SLC16A1 mRNA

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 16 member 2

increases expression

Zidovudine results in increased expression of SLC16A2 mRNA

NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771

G

solute carrier family 16 member 3

decreases expression

Zidovudine results in decreased expression of SLC16A3 mRNA

NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562

G

solute carrier family 16, member 4

increases expression

Zidovudine results in increased expression of SLC16A4 mRNA

NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117

G

solute carrier family 16, member 6

decreases expression
increases expression

Zidovudine results in decreased expression of SLC16A6 mRNA
Zidovudine results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 17, member 2

decreases expression

Zidovudine results in decreased expression of SLC17A2 mRNA

NCBI chr17:41,318,312...41,339,012
Ensembl chr17:41,319,701...41,336,325

G

solute carrier family 17 member 8

increases expression

Zidovudine results in increased expression of SLC17A8 mRNA

NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079

G

solute carrier family 19 member 2

decreases expression

Zidovudine results in decreased expression of SLC19A2 mRNA

NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172

G

solute carrier family 19 member 3

decreases expression

Zidovudine results in decreased expression of SLC19A3 mRNA

NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337

G

solute carrier family 1 member 1

increases expression

Zidovudine results in increased expression of SLC1A1 mRNA

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 1 member 4

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A4 mRNA
Zidovudine results in increased expression of SLC1A4 mRNA

PMID:15784690 PMID:24292225

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 1 member 5

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A5 mRNA

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 20 member 1

decreases expression

Zidovudine results in decreased expression of SLC20A1 mRNA

NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051

G

solute carrier family 20 member 2

increases expression

Zidovudine results in increased expression of SLC20A2 mRNA

NCBI chr16:69,460,850...69,551,418
Ensembl chr16:69,460,462...69,521,711

G

solute carrier family 22, member 15

decreases expression

Zidovudine results in decreased expression of SLC22A15 mRNA

NCBI chr 2:189,298,836...189,359,902
Ensembl chr 2:189,298,832...189,358,792

G

solute carrier family 22, member 17

increases expression

Zidovudine results in increased expression of SLC22A17 mRNA

NCBI chr15:28,382,285...28,389,435
Ensembl chr15:28,382,292...28,388,799

G

solute carrier family 22, member 18

increases expression

Zidovudine results in increased expression of SLC22A18 mRNA

NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975

G

solute carrier family 22, member 23

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNA

NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790

G

solute carrier family 22, member 25

decreases expression

Zidovudine results in decreased expression of SLC22A9 mRNA

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 22 member 4

increases expression

Zidovudine results in increased expression of SLC22A4 mRNA

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 5

increases expression

Zidovudine results in increased expression of SLC22A5 mRNA

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 22 member 7

increases uptake
increases expression

SLC22A7 protein results in increased uptake of Zidovudine
Zidovudine results in increased expression of SLC22A7 mRNA

PMID:15901346 PMID:24292225

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 23 member 2

increases expression

Zidovudine results in increased expression of SLC23A2 mRNA

NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343

G

solute carrier family 24 member 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC24A4 mRNA

NCBI chr 6:121,279,590...121,419,811
Ensembl chr 6:121,280,031...121,414,949

G

solute carrier family 25 member 1

increases expression

Zidovudine results in increased expression of SLC25A1 mRNA

NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781

G

solute carrier family 25 member 10

increases expression

Zidovudine results in increased expression of SLC25A10 mRNA

NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556

G

solute carrier family 25 member 11

increases expression

Zidovudine results in increased expression of SLC25A11 mRNA

NCBI chr10:55,357,590...55,360,441
Ensembl chr10:55,357,597...55,360,410

G

solute carrier family 25 member 12

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A12 mRNA

NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100

G

solute carrier family 25 member 15

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A15 mRNA

NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010

G

solute carrier family 25 member 16

increases expression

Zidovudine results in increased expression of SLC25A16 mRNA

NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319

G

solute carrier family 25 member 19

multiple interactions

SLC25A19 protein affects the susceptibility to [Zidovudine co-treated with Lamivudine co-treated with Indinavir]
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A19 mRNA

PMID:15951836 PMID:18313992

NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447

G

solute carrier family 25 member 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A2 mRNA

NCBI chr18:29,452,943...29,456,324
Ensembl chr18:29,453,582...29,460,383

G

solute carrier family 25 member 20

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A20 mRNA
Zidovudine results in increased expression of SLC25A20 mRNA

PMID:18313992 PMID:24292225

NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512

G

solute carrier family 25 member 21

increases expression

Zidovudine results in increased expression of SLC25A21 mRNA

NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680

G

solute carrier family 25 member 29

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A29 mRNA

NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940

G

solute carrier family 25 member 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A3 mRNA

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 25 member 4

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A4 mRNA

NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733

G

solute carrier family 26 member 1

increases expression

Zidovudine results in increased expression of SLC26A1 mRNA

NCBI chr14:1,040,565...1,045,851
Ensembl chr14:1,040,243...1,045,849

G

solute carrier family 26 member 11

increases expression

Zidovudine results in increased expression of SLC26A11 mRNA

NCBI chr10:104,613,498...104,635,873
Ensembl chr10:104,613,564...104,635,970

G

solute carrier family 26 member 2

increases expression

Zidovudine results in increased expression of SLC26A2 mRNA

NCBI chr18:54,648,276...54,666,627
Ensembl chr18:54,652,951...54,666,626

G

solute carrier family 26 member 3

decreases expression

Zidovudine results in decreased expression of SLC26A3 mRNA

NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772

G

solute carrier family 26 member 9

increases expression

Zidovudine results in increased expression of SLC26A9 mRNA

NCBI chr13:43,177,806...43,205,450
Ensembl chr13:43,177,867...43,204,330

G

solute carrier family 27 member 2

increases expression

Zidovudine results in increased expression of SLC27A2 mRNA

NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208

G

solute carrier family 28 member 1

affects transport
multiple interactions
increases uptake

SLC28A1 protein affects the transport of Zidovudine
Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]
SLC28A1 protein results in increased uptake of Zidovudine

PMID:8027026 PMID:8700147 PMID:8713072 PMID:9124315

NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464

G

solute carrier family 28 member 3

increases expression

Zidovudine results in increased expression of SLC28A3 mRNA

NCBI chr17:6,062,563...6,112,965
Ensembl chr17:6,062,549...6,114,038

G

solute carrier family 29 member 1

increases expression

Zidovudine results in increased expression of SLC29A1 mRNA

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier family 29 member 3

affects transport
increases expression

SLC29A3 protein affects the transport of Zidovudine
Zidovudine results in increased expression of SLC29A3 mRNA

PMID:19164483 PMID:24292225

NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388

G

solute carrier family 2 member 1

decreases expression

Zidovudine results in decreased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 10

decreases expression

Zidovudine results in decreased expression of SLC2A10 mRNA

NCBI chr 3:154,240,395...154,252,690
Ensembl chr 3:154,240,391...154,252,690

G

solute carrier family 2 member 3

decreases expression

Zidovudine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 2 member 4

affects expression

Zidovudine affects the expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 2 member 6

increases expression

Zidovudine results in increased expression of SLC2A6 mRNA

NCBI chr 3:10,348,395...10,355,208
Ensembl chr 3:10,348,395...10,355,208

G

solute carrier family 2 member 8

increases expression

Zidovudine results in increased expression of SLC2A8 mRNA

NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464

G

solute carrier family 30 member 1

increases expression

Zidovudine results in increased expression of SLC30A1 mRNA

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 30 member 3

increases expression

Zidovudine results in increased expression of SLC30A3 mRNA

NCBI chr 6:25,264,310...25,284,720
Ensembl chr 6:25,275,528...25,284,720

G

solute carrier family 30 member 7

increases expression

Zidovudine results in increased expression of SLC30A7 mRNA

NCBI chr 2:203,855,484...203,922,155
Ensembl chr 2:203,859,175...203,922,132

G

solute carrier family 30 member 9

increases expression

Zidovudine results in increased expression of SLC30A9 mRNA

NCBI chr14:40,816,284...40,870,992
Ensembl chr14:40,816,290...40,870,929

G

solute carrier family 31 member 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC31A1 mRNA

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 31 member 2

increases expression

Zidovudine results in increased expression of SLC31A2 mRNA

NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542

G

solute carrier family 35, member A4

increases expression

Zidovudine results in increased expression of SLC35A4 mRNA

NCBI chr18:28,280,483...28,284,610
Ensembl chr18:28,279,750...28,284,725

G

solute carrier family 35 member B3

increases expression

Zidovudine results in increased expression of SLC35B3 mRNA

NCBI chr17:25,846,590...25,873,115
Ensembl chr17:25,846,748...25,872,557

G

solute carrier family 35 member B4

increases expression

Zidovudine results in increased expression of SLC35B4 mRNA

NCBI chr 4:62,776,993...62,799,013
Ensembl chr 4:62,776,993...62,799,003

G

solute carrier family 35 member D1

increases expression

Zidovudine results in increased expression of SLC35D1 mRNA

NCBI chr 5:117,928,628...117,981,289
Ensembl chr 5:117,934,352...117,981,311

G

solute carrier family 35, member F2

increases expression

Zidovudine results in increased expression of SLC35F2 mRNA

NCBI chr 8:54,159,970...54,203,614
Ensembl chr 8:54,159,970...54,203,612

G

solute carrier family 37 member 1

increases expression

Zidovudine results in increased expression of SLC37A1 mRNA

NCBI chr20:9,360,501...9,433,895
Ensembl chr20:9,378,836...9,433,892

G

solute carrier family 37 member 2

increases expression

Zidovudine results in increased expression of SLC37A2 mRNA

NCBI chr 8:36,945,787...36,971,748
Ensembl chr 8:36,946,930...36,971,482

G

solute carrier family 38, member 2

decreases expression

Zidovudine results in decreased expression of SLC38A2 mRNA

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 38, member 3

increases expression

Zidovudine results in increased expression of SLC38A3 mRNA

NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988

G

solute carrier family 38, member 4

decreases expression

Zidovudine results in decreased expression of SLC38A4 mRNA

NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995

G

solute carrier family 38, member 5

decreases expression

Zidovudine results in decreased expression of SLC38A5 mRNA

NCBI chr X:14,213,727...14,222,498
Ensembl chr X:14,213,729...14,222,498

G

solute carrier family 38, member 6

increases expression

Zidovudine results in increased expression of SLC38A6 mRNA

NCBI chr 6:91,987,652...92,076,416
Ensembl chr 6:91,987,672...92,049,935

G

solute carrier family 39 member 10

decreases expression

Zidovudine results in decreased expression of SLC39A10 mRNA

NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325

G

solute carrier family 39 member 14

decreases expression

Zidovudine results in decreased expression of SLC39A14 mRNA

NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 39, member 9

increases expression

Zidovudine results in increased expression of SLC39A9 mRNA

NCBI chr 6:100,291,537...100,330,419
Ensembl chr 6:100,291,573...100,330,408

G

solute carrier family 3 member 2

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC3A2 mRNA
Zidovudine results in increased expression of SLC3A2 mRNA

PMID:15784690 PMID:24292225

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 40 member 1

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC40A1 mRNA
Zidovudine results in increased expression of SLC40A1 mRNA

PMID:18313992 PMID:24292225

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 4 member 2

increases expression

Zidovudine results in increased expression of SLC4A2 mRNA

NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965

G

solute carrier family 5 member 3

decreases expression

Zidovudine results in decreased expression of SLC5A3 mRNA

NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883

G

solute carrier family 6 member 11

increases expression

Zidovudine results in increased expression of SLC6A11 mRNA

NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443

G

solute carrier family 6 member 12

increases expression

Zidovudine results in increased expression of SLC6A12 mRNA

NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750

G

solute carrier family 6 member 2

increases expression

Zidovudine results in increased expression of SLC6A2 mRNA

NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357

G

solute carrier family 6 member 8

decreases expression

Zidovudine results in decreased expression of SLC6A8 mRNA

NCBI chr X:151,384,675...151,393,979
Ensembl chr X:151,384,675...151,393,979

G

solute carrier family 7 member 10

decreases expression
increases expression

Zidovudine results in decreased expression of SLC7A10 mRNA
Zidovudine results in increased expression of SLC7A10 mRNA

NCBI chr 1:87,829,084...87,845,073
Ensembl chr 1:87,829,175...87,845,071

G

solute carrier family 7 member 2

decreases expression

Zidovudine results in decreased expression of SLC7A2 mRNA

NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784

G

solute carrier family 7 member 5

increases expression

Zidovudine results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier family 7 member 7

multiple interactions
increases expression

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC7A7 mRNA
Zidovudine results in increased expression of SLC7A7 mRNA

PMID:20370541 PMID:24292225

NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648

G

solute carrier family 7 member 8

increases expression

Zidovudine results in increased expression of SLC7A8 mRNA

NCBI chr15:28,183,013...28,242,717
Ensembl chr15:28,183,015...28,242,717

G

solute carrier family 7 member 9

increases expression

Zidovudine results in increased expression of SLC7A9 mRNA

NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641

G

solute carrier family 9 member A1

increases expression

Zidovudine results in increased expression of SLC9A1 mRNA

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

solute carrier organic anion transporter family, member 2a1

decreases expression

Zidovudine results in decreased expression of SLCO2A1 mRNA

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546

G

solute carrier organic anion transporter family, member 2b1

increases expression
decreases expression

Zidovudine results in increased expression of SLCO2B1 mRNA
Zidovudine results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

solute carrier organic anion transporter family, member 4a1

decreases expression

Zidovudine results in decreased expression of SLCO4A1 mRNA

NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305

G

superoxide dismutase 2

decreases response to substance
multiple interactions

SOD2 protein results in decreased susceptibility to Zidovudine
[SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine

PMID:19398959 PMID:19501153

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

serine peptidase inhibitor, Kazal type 5

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of SPINK5 mRNA

NCBI chr18:36,264,452...36,333,143
Ensembl chr18:36,264,452...36,332,185

G

sequestosome 1

increases expression

Zidovudine results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroidogenic acute regulatory protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNA

NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967

G

stanniocalcin 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

SUB1 regulator of transcription

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNA

NCBI chr 2:61,005,646...61,020,486
Ensembl chr 2:61,005,666...61,020,436
Ensembl chr 2:61,005,666...61,020,436

G

transcription elongation factor A1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TCEA1 mRNA

NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745
Ensembl chr15:14,631,454...14,668,745

G

transcobalamin 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNA

NCBI chr14:78,813,343...78,828,549
Ensembl chr14:78,813,343...78,828,489

G

telomerase reverse transcriptase

decreases activity

Zidovudine results in decreased activity of TERT protein

PMID:16601281 PMID:18097608

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transcription factor A, mitochondrial

increases expression

Zidovudine results in increased expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor AP-2 alpha

decreases expression

Zidovudine results in decreased expression of TFAP2A mRNA

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

transcription factor EB

decreases expression

Zidovudine results in decreased expression of TFEB protein

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

G

translocase of inner mitochondrial membrane 17b

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM17B mRNA

NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416

G

translocase of inner mitochondrial membrane 23

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM23 mRNA

NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379

G

TIMP metallopeptidase inhibitor 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

thymidine kinase 1

decreases response to substance
increases expression
decreases expression
increases mutagenesis
increases response to substance
increases metabolic processing
increases activity
increases methylation
decreases activity
affects transport
multiple interactions

TK1 gene modified form results in decreased susceptibility to Zidovudine
Zidovudine results in increased expression of TK1 mRNA; Zidovudine results in increased expression of TK1 protein
Zidovudine results in decreased expression of TK1 mRNA; Zidovudine results in decreased expression of TK1 protein
Zidovudine results in increased mutagenesis of TK1 gene
TK1 protein results in increased susceptibility to Zidovudine
TK1 protein results in increased metabolism of Zidovudine
Zidovudine results in increased activity of TK1 protein
Zidovudine results in increased methylation of TK1 exon
Zidovudine results in decreased activity of TK1 protein
TK1 protein affects the transport of Zidovudine
Ethanol inhibits the reaction [Zidovudine results in increased activity of TK1 protein]; Zidovudine inhibits the reaction [Ethanol results in decreased activity of TK1 protein]

PMID:8915012 PMID:8941356 PMID:11923581 PMID:15013700 PMID:15708581 More...

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

thymidine kinase 2

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of TK2 mRNA
Zidovudine results in increased expression of TK2 mRNA

PMID:18313992 PMID:24292225

NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924

G

toll-like receptor 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNA

NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754

G

transmembrane protein 97

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNA

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

tenascin C

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

decreases expression
multiple interactions
increases expression

Zidovudine analog results in decreased expression of TNF protein
[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]
Zidovudine results in increased expression of TNF protein

PMID:12729831 PMID:17668557 PMID:28619387

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 13b

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF13B mRNA

NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693

G

troponin I2, fast skeletal type

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNNI2 mRNA

NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560

G

troponin I3, cardiac type

affects localization

Zidovudine affects the localization of TNNI3 protein

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

tumor protein p53

increases expression

Zidovudine results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tRNA aspartic acid methyltransferase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA

NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439

G

tribbles pseudokinase 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 42

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TRIM42 mRNA

NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268

G

triple QxxK/R motif containing

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRIQK mRNA

NCBI chr 5:26,391,511...26,464,422
Ensembl chr 5:26,391,552...26,464,421

G

tRNA methyltransferase 44

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TRMT44 mRNA

NCBI chr14:75,175,331...75,204,291
Ensembl chr14:75,182,029...75,200,147

G

tetratricopeptide repeat domain 21A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TTC21A mRNA

NCBI chr 8:119,667,044...119,702,028
Ensembl chr 8:119,666,933...119,702,456

G

twinkle mtDNA helicase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of TWNK mRNA

NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802

G

thymidine phosphorylase

multiple interactions
increases expression
increases activity

[5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]; [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridine
Zidovudine results in increased expression of TYMP mRNA; Zidovudine results in increased expression of TYMP protein

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

thymidylate synthetase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

tyrosinase-related protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of TYRP1 mRNA

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

G

uncoupling protein 1

increases expression
decreases expression

Zidovudine results in increased expression of UCP1 mRNA
Zidovudine results in decreased expression of UCP1 mRNA

PMID:14518702 PMID:17926646

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases glucuronidation

UGT2B1 protein results in increased glucuronidation of Zidovudine

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation
multiple interactions
decreases expression
increases expression

UGT2B7 protein results in increased glucuronidation of Zidovudine
10-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; 4'-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; 7-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; shikonin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]
Zidovudine results in decreased expression of UGT2B7 mRNA; Zidovudine results in decreased expression of UGT2B7 protein
Zidovudine results in increased expression of UGT2B7 mRNA; Zidovudine results in increased expression of UGT2B7 protein

PMID:10772627 PMID:17898154 PMID:24292225 PMID:25393417 PMID:31128210

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

unc-51 like autophagy activating kinase 1

decreases phosphorylation

Zidovudine results in decreased phosphorylation of ULK1 protein

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRB mRNA

NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA

PMID:17526437 PMID:18313992

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of UQCRC2 mRNA

NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453

G

ubiquitin specific peptidase 18

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNA

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

voltage-dependent anion channel 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of VDAC1 mRNA

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

vitamin D receptor

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of VDR mRNA

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vacuolar protein sorting 4 homolog B

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of VPS4B mRNA

NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229

G

tryptophanyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WD repeat domain 62

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of WDR62 mRNA

NCBI chr 1:85,491,531...85,530,643
Ensembl chr 1:85,491,533...85,530,637

G

Wnt family member 10A

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of WNT10A mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of WNT10A mRNA

NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400

G

XPA, DNA damage recognition and repair factor

increases expression

Zidovudine results in increased expression of XPA mRNA; Zidovudine results in increased expression of XPA protein

PMID:21192964 PMID:23675285

NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726

G

XPC complex subunit, DNA damage recognition and repair factor

decreases response to substance
increases expression

XPC protein results in decreased susceptibility to Zidovudine
Zidovudine results in increased expression of XPC mRNA; Zidovudine results in increased expression of XPC protein

PMID:21192964 PMID:23675285

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

tyrosyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of YARS1 mRNA

NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833

G

zinc finger protein 629

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of ZNF629 mRNA

NCBI chr 1:182,217,499...182,258,585
Ensembl chr 1:182,210,935...182,230,016

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19917
chemical entity	19915
atom	19915
nonmetal atom	19838
nitrogen atom	19017
nitrogen molecular entity	19017
azide	523
(3-bromo-4-hydroxy-5-nitrophenyl)acetyl azide	0
(4-hydroxy-3-nitrophenyl)acetyl azide	0
(allyl 7-azido-3,7-dideoxy-beta-L-gulo-oct-2-ulopyranosid)onic acid	0
1-(2-(diphenylmethoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine	1
1-(4-azido-2-nitrophenyl)amino-3-(1-oxyl-2,2,5,5-pyrrolidin-3-ylcarbonylamino)propan-2-yl diphosphate	0
2-deoxy-alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-N3	0
3-(4-azidobenzyl)-4-hydroxycoumarin	0
4-Azidobenzenesulfonamide	0
4-[2-(diphenylmethoxy)ethyl]-1-[(4-azidophenyl)-methyl]-piperidine	1
4-azidophenylalanine +	0
5-(3-azidopropylamino)-5-oxopentanoic acid +	0
N-\{beta-D-Man-(1->2)-beta-D-Man-(1->2)-beta-D-ManO[CH2]3S[CH2]2NHC(O)[CH2O]4C(O)[CH2]2S[CH2]2C(O)\}-YGKDVKDLFDYAQE-NH-[CH2O]3[CH2]2C(O)NHC(CO2H)[CH2]4N3 +	0
N-benzyloxycarbonylaminoethyl-4-azido-3-O-benzoyl-2-O-methyl-4,6-dideoxy-alpha-D-glucopyranoside	0
alpha-D-Ara-(1->5)-[alpha-D-Ara-(1->5)-alpha-D-Ara-(1->3)]-alpha-D-Ara-(1->5)-alpha-D-Ara-(1->5)-alpha-D-Ara-(1->2)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)]-alpha-D-Man-(1->6)-alpha-D-Man-(1->6)-alpha-D-ManO[CH2]6N3	0
beta-D-Galp-(1->4)-beta-D-Glcp-(1->6)-[beta-D-Glcp-(1->4)]-beta-D-GlcpNAcOCH2CH2N3	0
beta-D-GlcpA-(1->4)-beta-D-Glcp-(1->3)-beta-D-GlcpA-(1->4)-beta-D-GlcpOCH2CH2N3	0
poly(4-azidomethylstyrene)	0
tetraacetyl-N-azidoacetyl-D-mannosamine	0
zidovudine	518
Path 2
Term	Annotations
CHEBI ontology	19917
subatomic particle	19915
composite particle	19915
hadron	19915
baryon	19915
nucleon	19915
atomic nucleus	19915
atom	19915
main group element atom	19855
p-block element atom	19855
pnictogen	19114
nitrogen atom	19017
nitrogen molecular entity	19017
azide	523
(3-bromo-4-hydroxy-5-nitrophenyl)acetyl azide	0
(4-hydroxy-3-nitrophenyl)acetyl azide	0
(allyl 7-azido-3,7-dideoxy-beta-L-gulo-oct-2-ulopyranosid)onic acid	0
1-(2-(diphenylmethoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine	1
1-(4-azido-2-nitrophenyl)amino-3-(1-oxyl-2,2,5,5-pyrrolidin-3-ylcarbonylamino)propan-2-yl diphosphate	0
2-deoxy-alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-N3	0
3-(4-azidobenzyl)-4-hydroxycoumarin	0
4-Azidobenzenesulfonamide	0
4-[2-(diphenylmethoxy)ethyl]-1-[(4-azidophenyl)-methyl]-piperidine	1
4-azidophenylalanine +	0
5-(3-azidopropylamino)-5-oxopentanoic acid +	0
N-\{beta-D-Man-(1->2)-beta-D-Man-(1->2)-beta-D-ManO[CH2]3S[CH2]2NHC(O)[CH2O]4C(O)[CH2]2S[CH2]2C(O)\}-YGKDVKDLFDYAQE-NH-[CH2O]3[CH2]2C(O)NHC(CO2H)[CH2]4N3 +	0
N-benzyloxycarbonylaminoethyl-4-azido-3-O-benzoyl-2-O-methyl-4,6-dideoxy-alpha-D-glucopyranoside	0
alpha-D-Ara-(1->5)-[alpha-D-Ara-(1->5)-alpha-D-Ara-(1->3)]-alpha-D-Ara-(1->5)-alpha-D-Ara-(1->5)-alpha-D-Ara-(1->2)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)]-alpha-D-Man-(1->6)-alpha-D-Man-(1->6)-alpha-D-ManO[CH2]6N3	0
beta-D-Galp-(1->4)-beta-D-Glcp-(1->6)-[beta-D-Glcp-(1->4)]-beta-D-GlcpNAcOCH2CH2N3	0
beta-D-GlcpA-(1->4)-beta-D-Glcp-(1->3)-beta-D-GlcpA-(1->4)-beta-D-GlcpOCH2CH2N3	0
poly(4-azidomethylstyrene)	0
tetraacetyl-N-azidoacetyl-D-mannosamine	0
zidovudine	518

paths to the root