Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7-hydroxyflavone
go back to main search page
Accession:CHEBI:2268 term browser browse the term
Definition:A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.
Synonyms:exact_synonym: 7-hydroxy-2-phenyl-4H-chromen-4-one
 related_synonym: 7-Hydroxy-2-phenyl-4-benzopyrone;   7-hydroxy-2-phenyl-4-oxo-4H-1-benzopyran;   7-hydroxy-2-phenyl-4H-1-benzopyran-4-one;   Formula=C15H10O3;   InChI=1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H;   InChIKey=MQGPSCMMNJKMHQ-UHFFFAOYSA-N;   SMILES=C1(=CC(=O)C2=C(O1)C=C(O)C=C2)C=3C=CC=CC3
 xref: CAS:6665-86-7;   KEGG:C11264;   KNApSAcK:C00020218;   LINCS:LSM-4663
 xref_mesh: MESH:C429845
 xref: PMID:16508185;   PMID:24689737;   PMID:26197517;   PMID:26583833;   PMID:28166217;   PMID:28214719;   PMID:28295316;   Patent:PL373688;   Reaxys:194089


show annotations for term's descendants           Sort by:
 
7-hydroxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO 7-hydroxyflavone results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP19A1 protein CTD PMID:15319488 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A1 protein CTD PMID:21053930 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO 7-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases activity
multiple interactions
ISO 7-hydroxyflavone results in decreased activity of CYP3A4 protein
7-hydroxyflavone results in increased activity of CYP3A4 protein
[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam
CTD PMID:21053930 PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 7-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO 7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
7-hydroxyflavone results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19808
      atom 19807
        nonmetal atom 19694
          oxygen atom 19432
            oxygen molecular entity 19432
              flavonoids 11136
                flavonoid 6515
                  hydroxyflavonoid 9
                    7-hydroxyflavone 9
                      7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside] 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic molecule 19556
                              organic cyclic compound 19347
                                organic heterocyclic compound 18580
                                  oxacycle 17586
                                    benzopyran 10409
                                      1-benzopyran 10135
                                        flavonoid 6515
                                          hydroxyflavonoid 9
                                            7-hydroxyflavone 9
                                              7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside] 0
paths to the root