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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7-hydroxyflavone
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Accession:CHEBI:2268 term browser browse the term
Definition:A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.
Synonyms:exact_synonym: 7-hydroxy-2-phenyl-4H-chromen-4-one
 related_synonym: 7-Hydroxy-2-phenyl-4-benzopyrone;   7-hydroxy-2-phenyl-4-oxo-4H-1-benzopyran;   7-hydroxy-2-phenyl-4H-1-benzopyran-4-one;   Formula=C15H10O3;   InChI=1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H;   InChIKey=MQGPSCMMNJKMHQ-UHFFFAOYSA-N;   SMILES=C1(=CC(=O)C2=C(O1)C=C(O)C=C2)C=3C=CC=CC3
 xref: CAS:6665-86-7;   KEGG:C11264;   KNApSAcK:C00020218;   LINCS:LSM-4663
 xref_mesh: MESH:C429845
 xref: PMID:16508185;   PMID:24689737;   PMID:26197517;   PMID:26583833;   PMID:28166217;   PMID:28214719;   PMID:28295316;   Patent:PL373688;   Reaxys:194089


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7-hydroxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO 7-hydroxyflavone results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP19A1 protein CTD PMID:15319488 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A1 protein CTD PMID:21053930 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO 7-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 7-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO 7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
7-hydroxyflavone results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19775
    chemical entity 19775
      atom 19774
        nonmetal atom 19655
          oxygen atom 19368
            oxygen molecular entity 19368
              flavonoids 10819
                flavonoid 6519
                  hydroxyflavonoid 8
                    7-hydroxyflavone 8
                      7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside] 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19775
    subatomic particle 19774
      composite particle 19774
        hadron 19774
          baryon 19774
            nucleon 19774
              atomic nucleus 19774
                atom 19774
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19584
                        carbon atom 19574
                          organic molecular entity 19574
                            organic molecule 19508
                              organic cyclic compound 19338
                                organic heterocyclic compound 18567
                                  oxacycle 17557
                                    benzopyran 10281
                                      1-benzopyran 10003
                                        flavonoid 6519
                                          hydroxyflavonoid 8
                                            7-hydroxyflavone 8
                                              7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside] 0
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