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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7-hydroxyflavone
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Accession:CHEBI:2268 term browser browse the term
Definition:A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.
Synonyms:exact_synonym: 7-hydroxy-2-phenyl-4H-chromen-4-one
 related_synonym: 7-Hydroxy-2-phenyl-4-benzopyrone;   7-hydroxy-2-phenyl-4-oxo-4H-1-benzopyran;   7-hydroxy-2-phenyl-4H-1-benzopyran-4-one;   Formula=C15H10O3;   InChI=1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H;   InChIKey=MQGPSCMMNJKMHQ-UHFFFAOYSA-N;   SMILES=C1(=CC(=O)C2=C(O1)C=C(O)C=C2)C=3C=CC=CC3
 xref: CAS:6665-86-7;   KEGG:C11264;   KNApSAcK:C00020218;   LINCS:LSM-4663
 xref_mesh: MESH:C429845
 xref: PMID:16508185;   PMID:24689737;   PMID:26197517;   PMID:26583833;   PMID:28166217;   PMID:28214719;   PMID:28295316;   Patent:PL373688;   Reaxys:194089


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7-hydroxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions ISO 7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO 7-hydroxyflavone results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP19A1 protein CTD PMID:15319488 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A1 protein CTD PMID:21053930 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO 7-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO 7-hydroxyflavone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions
increases activity		 ISO 7-hydroxyflavone results in decreased activity of CYP3A4 protein
[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam		 CTD PMID:21053930 PMID:31756459 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO 7-hydroxyflavone inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity		 ISO 7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
7-hydroxyflavone results in decreased activity of SLC2A1 protein		 CTD PMID:14642735 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          oxygen atom 19520
            oxygen molecular entity 19490
              flavonoids 11607
                flavonoid 7190
                  hydroxyflavonoid 11
                    7-hydroxyflavone 10
                      7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside] 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  oxacycle 17819
                                    benzopyran 11950
                                      1-benzopyran 11702
                                        flavonoid 7190
                                          hydroxyflavonoid 11
                                            7-hydroxyflavone 10
                                              7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside] 0
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