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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aspartic acid derivative
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Accession:CHEBI:22661 term browser browse the term
Definition:An amino acid derivative resulting from reaction of aspartic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of aspartic acid by a heteroatom. The definition normally excludes peptides containing aspartic acid residues.



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Ac-Asp-Glu term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folh1 folate hydrolase 1 affects binding
multiple interactions
ISO isospaglumic acid binds to FOLH1 protein
[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]
CTD PMID:24508213 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddo D-aspartate oxidase affects abundance ISO DDO protein affects the abundance of N-Methylaspartate CTD PMID:16516413 NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions
ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]
CTD PMID:31945382 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
EXP N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
CTD PMID:22639866 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
EXP N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
CTD PMID:22639866 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nefl neurofilament light chain multiple interactions
decreases expression
EXP 3-(2-((phenylamino)carbonyl)ethenyl)-4,6-dichloroindole-2-carboxylic acid inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases ADP-ribosylation EXP N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      atom 19794
        nonmetal atom 19681
          nitrogen atom 18762
            nitrogen molecular entity 18762
              organonitrogen compound 18540
                amino acid derivative 11116
                  aspartic acid derivative 8
                    2-[(2E)-2-(2,6-Dicarboxy-2,3-dihydro-1H-pyridin-4-ylidene)ethylidene]azaniumyl-4-hydroxy-4-oxobutanoate 0
                    2-amino-3-phenylmethoxybutanedioic acid 0
                    3-hydroxyaspartic acid + 0
                    Argininosuccinic acid 0
                    Aspartic acid, N-salicyloyl- 0
                    Aspartic acid-13C4,15N 0
                    Aspergillomarasmine A 0
                    Caffeoyl aspartic acid 0
                    D-aspartic acid derivative + 7
                    L-aspartic acid beta-benzyl ester 0
                    L-aspartic acid derivative + 1
                    N-(PHOSPHONACETYL)-L-ASPARTIC ACID 0
                    N-3-Indolylacety DL-aspartic acid 0
                    N-Acetyl-DL-aspartic acid 0
                    N-Benzoylaspartic acid 0
                    N-Feruloylaspartic acid 0
                    N-Methyl-DL-aspartic acid 0
                    N-Phenylacetylaspartic acid 0
                    N-Salicyloylaspartic acid 0
                    N-[4'-hydroxy-(E)-cinnamoyl]-L-aspartic acid 0
                    N-acyl-aspartic acid + 1
                    N-amidinoaspartic acid + 0
                    N-carbamoylaspartic acid + 0
                    N-methyl L-aspartic acid 0
                    aspartic 1-amide + 0
                    hydroxycinnamoyl aspartate 0
                    iminoaspartic acid 0
                    peptidyl-aspartate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      p-block molecular entity 19693
                        carbon group molecular entity 19614
                          organic molecular entity 19604
                            heteroorganic entity 19273
                              organonitrogen compound 18540
                                amino acid derivative 11116
                                  aspartic acid derivative 8
                                    2-[(2E)-2-(2,6-Dicarboxy-2,3-dihydro-1H-pyridin-4-ylidene)ethylidene]azaniumyl-4-hydroxy-4-oxobutanoate 0
                                    2-amino-3-phenylmethoxybutanedioic acid 0
                                    3-hydroxyaspartic acid + 0
                                    Argininosuccinic acid 0
                                    Aspartic acid, N-salicyloyl- 0
                                    Aspartic acid-13C4,15N 0
                                    Aspergillomarasmine A 0
                                    Caffeoyl aspartic acid 0
                                    D-aspartic acid derivative + 7
                                    L-aspartic acid beta-benzyl ester 0
                                    L-aspartic acid derivative + 1
                                    N-(PHOSPHONACETYL)-L-ASPARTIC ACID 0
                                    N-3-Indolylacety DL-aspartic acid 0
                                    N-Acetyl-DL-aspartic acid 0
                                    N-Benzoylaspartic acid 0
                                    N-Feruloylaspartic acid 0
                                    N-Methyl-DL-aspartic acid 0
                                    N-Phenylacetylaspartic acid 0
                                    N-Salicyloylaspartic acid 0
                                    N-[4'-hydroxy-(E)-cinnamoyl]-L-aspartic acid 0
                                    N-acyl-aspartic acid + 1
                                    N-amidinoaspartic acid + 0
                                    N-carbamoylaspartic acid + 0
                                    N-methyl L-aspartic acid 0
                                    aspartic 1-amide + 0
                                    hydroxycinnamoyl aspartate 0
                                    iminoaspartic acid 0
                                    peptidyl-aspartate 0
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