anthraquinone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	anthraquinone	go back to main search page
Accession:	CHEBI:22580	browse the term
Synonyms:	related_synonym:	anthracenequinones; anthraquinones

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Rat (514) Mouse (517) Human (533) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (533)

1-Amino-2,4-dibromoanthraquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

multiple interactions

1-amino-2,4-dibromoanthraquinone binds to and results in increased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

HRas proto-oncogene, GTPase

increases mutagenesis

1-amino-2,4-dibromoanthraquinone results in increased mutagenesis of HRAS gene

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

NFE2 like bZIP transcription factor 2

increases activity

1-amino-2,4-dibromoanthraquinone results in increased activity of NFE2L2 protein

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear receptor subfamily 1 group I member 3

increases activity

1-amino-2,4-dibromoanthraquinone results in increased activity of NR1I3 protein

NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244

1-hydroxyanthraquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

1-hydroxyanthraquinone results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

2-Aminoanthraquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

multiple interactions

2-aminoanthraquinone binds to and results in increased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

2-hydroxychrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions
increases chemical synthesis

[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
increases chemical synthesis

[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

Alizarin Red S binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

9,10-anthraquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

9,10-anthraquinone analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

BCL2 associated agonist of cell death

increases expression

9,10-anthraquinone analog results in increased expression of BAD protein

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BCL2 associated X, apoptosis regulator

increases expression

9,10-anthraquinone analog results in increased expression of BAX mRNA; 9,10-anthraquinone analog results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

9,10-anthraquinone analog results in decreased expression of BCL2 mRNA; 9,10-anthraquinone analog results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

decreases expression

9,10-anthraquinone analog results in decreased expression of BCL2L1 protein

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BCL2 like 11

increases expression

9,10-anthraquinone analog results in increased expression of BCL2L11 protein

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

caspase 3

increases activity
increases expression

9,10-anthraquinone analog results in increased activity of CASP3 protein
9,10-anthraquinone analog results in increased expression of CASP3 mRNA

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

increases activity

9,10-anthraquinone analog results in increased activity of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

C-C motif chemokine ligand 5

increases expression

9,10-anthraquinone results in increased expression of CCL5 mRNA

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

cyclin D1

decreases expression

9,10-anthraquinone analog results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin D2

decreases expression

9,10-anthraquinone analog results in decreased expression of CCND2 protein

NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353

G

prostaglandin-endoperoxide synthase 2

decreases expression

9,10-anthraquinone analog results in decreased expression of PTGS2 mRNA; 9,10-anthraquinone analog results in decreased expression of PTGS2 protein

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

alizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 1

decreases activity
multiple interactions

alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]

PMID:12379470 PMID:37515497

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

alizarin results in decreased activity of CYP1A2 protein

PMID:12379470 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

alizarin results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily A member 6

decreases activity

alizarin results in decreased activity of CYP2A6 protein

NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

alizarin results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily E member 1

decreases activity

alizarin results in decreased activity of CYP2E1 protein

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

estrogen receptor 1

multiple interactions

alizarin binds to and results in increased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

H2A.X variant histone

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

mitogen-activated protein kinase 1

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

N-acetyltransferase 1

decreases activity

alizarin results in decreased activity of NAT1 protein

NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of alizarin

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of alizarin

NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652

Aloe emodin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA]

NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463

G

aldo-keto reductase family 1 member B10

decreases activity

aloe emodin results in decreased activity of AKR1B10 protein

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C3

decreases activity

aloe emodin results in decreased activity of AKR1C3 protein

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

activating transcription factor 3

increases expression

aloe emodin results in increased expression of ATF3 mRNA

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

BCL2 associated X, apoptosis regulator

increases expression

aloe emodin results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein

PMID:19928967 PMID:22210228

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

increases activity
multiple interactions
increases cleavage
increases expression

aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein

PMID:19928967 PMID:22210228

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases activity
multiple interactions
increases expression

aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases activity
increases expression
multiple interactions

aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

carbonyl reductase 1

decreases activity

aloe emodin results in decreased activity of CBR1 protein

NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166

G

cytochrome c, somatic

increases expression

aloe emodin results in increased expression of CYCS protein

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 1

decreases activity

aloe emodin results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

aloe emodin results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

aloe emodin results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily B member 6

multiple interactions
increases chemical synthesis

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

aloe emodin results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

aloe emodin results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions
increases chemical synthesis

[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP3A4 protein results in increased chemical synthesis of aloe emodin

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

DNA damage inducible transcript 3

increases expression

aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

aloe emodin results in increased phosphorylation of EIF2S1 protein

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

fatty acid binding protein 4

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA]

NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236

G

Fas associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of FADD protein

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

Fas cell surface death receptor

increases expression

aloe emodin results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression

aloe emodin results in increased expression of FASLG protein

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

heat shock protein family A (Hsp70) member 5

increases expression

aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

lipoprotein lipase

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA]

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

N-acetyltransferase 1

multiple interactions
decreases expression

aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA

NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689

G

nitric oxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

peroxisome proliferator activated receptor gamma

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA]

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

prostaglandin-endoperoxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

resistin

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA]

NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455

G

sulfotransferase family 1A member 1

decreases activity

aloe emodin results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

sulfotransferase family 1E member 1

decreases activity

aloe emodin results in decreased activity of SULT1E1 protein

NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145

G

tumor necrosis factor

multiple interactions
increases expression

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein

PMID:19928967 PMID:22645054

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 1A

increases expression

aloe emodin results in increased expression of TNFRSF1A protein

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF receptor superfamily member 1B

increases expression

aloe emodin results in increased expression of TNFRSF1B protein

NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228

G

tumor protein p53

increases expression

aloe emodin results in increased expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

TNFRSF1A associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of TRADD protein

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of aloe emodin

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

X-box binding protein 1

increases splicing

aloe emodin results in increased splicing of XBP1 mRNA

NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597

anthraflavic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

albumin

affects binding

2,6-dihydroxyanthraquinone binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

cytochrome P450 family 1 subfamily A member 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily B member 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

PMID:12756209 PMID:14557274

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of 2,6-dihydroxyanthraquinone

NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652

aurantio-obtusin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

aurantio-obtusin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

acyl-CoA synthetase long chain family member 4

increases expression

aurantio-obtusin results in increased expression of ACSL4 protein

NCBI chr X:109,641,335...109,733,257
Ensembl chr X:109,624,244...109,733,403

G

BCL2 associated X, apoptosis regulator

increases expression

aurantio-obtusin results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

aurantio-obtusin results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 1

increases expression

aurantio-obtusin results in increased expression of CASP1 mRNA

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

increases cleavage
multiple interactions

aurantio-obtusin results in increased cleavage of CASP3 protein
aurantio-obtusin results in increased expression of and results in increased cleavage of CASP3 protein

PMID:34718095 PMID:35995123

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

C-C motif chemokine ligand 2

increases expression

aurantio-obtusin results in increased expression of CCL2 mRNA

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

CREB binding protein

increases phosphorylation

aurantio-obtusin results in increased phosphorylation of CREBBP protein

NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713

G

glutamic--pyruvic transaminase

increases expression

aurantio-obtusin results in increased expression of GPT protein

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

hepcidin antimicrobial peptide

decreases expression

aurantio-obtusin results in decreased expression of HAMP mRNA

NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143

G

interleukin 18

increases expression

aurantio-obtusin results in increased expression of IL18 mRNA; aurantio-obtusin results in increased expression of IL18 protein

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 beta

increases expression

aurantio-obtusin results in increased expression of IL1B mRNA; aurantio-obtusin results in increased expression of IL1B protein

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

increases expression

aurantio-obtusin results in increased expression of IL6 mRNA

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

potassium calcium-activated channel subfamily N member 4

increases expression

aurantio-obtusin results in increased expression of KCNN4 mRNA; aurantio-obtusin results in increased expression of KCNN4 protein

NCBI chr19:43,766,533...43,780,973
Ensembl chr19:43,766,533...43,780,976

G

nuclear factor kappa B subunit 1

decreases expression

aurantio-obtusin results in decreased expression of NFKB1 mRNA

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NLR family pyrin domain containing 3

increases expression

aurantio-obtusin results in increased expression of NLRP3 mRNA; aurantio-obtusin results in increased expression of NLRP3 protein

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

RELA proto-oncogene, NF-kB subunit

decreases expression

aurantio-obtusin results in decreased expression of RELA protein

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

solute carrier family 22 member 6

decreases activity

aurantio-obtusin results in decreased activity of SLC22A6 protein

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

decreases activity

aurantio-obtusin results in decreased activity of SLC22A8 protein

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

G

sialophorin

increases expression

aurantio-obtusin results in increased expression of SPN mRNA

NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876

G

tumor necrosis factor

increases expression

aurantio-obtusin results in increased expression of TNF mRNA

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

exportin 1

decreases expression

aurantio-obtusin results in decreased expression of XPO1 mRNA

NCBI chr 2:61,477,849...61,538,612
Ensembl chr 2:61,476,032...61,538,741

Capoamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

increases activity

capoamycin results in increased activity of AHR protein

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

chrysazin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

apoptosis inducing factor mitochondria associated 1

multiple interactions
increases expression

danthron affects the localization of and results in increased expression of AIFM1 protein
danthron results in increased expression of AIFM1 mRNA

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

albumin

affects binding

danthron binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

activating transcription factor 6

increases expression

danthron results in increased expression of ATF6 protein

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

BCL2 associated X, apoptosis regulator

increases expression

danthron results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

danthron results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

increases expression
decreases expression

danthron results in increased expression of BCL2L1 protein
danthron results in decreased expression of BCL2L1 protein

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BH3 interacting domain death agonist

increases expression

danthron results in increased expression of BID protein

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 2

decreases expression

danthron results in decreased expression of BIRC2 protein

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

increases expression

danthron results in increased expression of BIRC3 protein

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

baculoviral IAP repeat containing 5

decreases expression

danthron results in decreased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

caspase 3

multiple interactions
increases expression

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 protein
danthron results in increased expression of CASP3 mRNA

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions
increases expression

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]; danthron results in increased activity of and results in increased expression of CASP8 protein
danthron results in increased expression of CASP8 mRNA

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
increases expression

benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein]; danthron results in increased activity of and results in increased expression of CASP9 protein
danthron results in increased expression of CASP9 mRNA

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cytochrome c, somatic

multiple interactions

danthron affects the localization of and results in increased expression of CYCS protein

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

danthron results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

DNA damage inducible transcript 3

increases expression

danthron results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

diablo IAP-binding mitochondrial protein

increases expression

danthron results in increased expression of DIABLO protein

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

G

endonuclease G

increases expression
multiple interactions

danthron results in increased expression of ENDOG mRNA
danthron affects the localization of and results in increased expression of ENDOG protein

NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676

G

Fas cell surface death receptor

increases expression

danthron results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression

danthron results in increased expression of FASLG protein

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

heat shock protein family A (Hsp70) member 5

increases expression

danthron results in increased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

superoxide dismutase 1

decreases expression

danthron results in decreased expression of SOD1 protein

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

decreases expression

danthron results in decreased expression of SOD2 protein

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

TNF superfamily member 10

increases expression

danthron results in increased expression of TNFSF10 protein

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

X-linked inhibitor of apoptosis

decreases expression

danthron results in decreased expression of XIAP protein

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

chrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily C member 2

increases expression

chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 4 (PEL blood group)

increases expression

chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

aryl hydrocarbon receptor

multiple interactions

chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

AKT serine/threonine kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

BCL2 antagonist/killer 1

increases expression

chrysophanic acid results in increased expression of BAK1 protein

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

increases expression

chrysophanic acid results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

cytochrome P450 family 1 subfamily A member 1

decreases activity

chrysophanic acid results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity
multiple interactions
increases metabolic processing

chrysophanic acid results in decreased activity of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

PMID:27633141 PMID:29698620 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

decreases activity

chrysophanic acid results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 2 subfamily B member 6

multiple interactions
increases metabolic processing

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

chrysophanic acid results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 3 subfamily A member 4

increases metabolic processing
multiple interactions
increases chemical synthesis

CYP3A4 protein results in increased metabolism of chrysophanic acid
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 7 subfamily A member 1

increases expression

chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein

NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898

G

DNA damage inducible transcript 3

increases expression

chrysophanic acid results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation
multiple interactions

chrysophanic acid results in increased phosphorylation of EIF2AK3 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

chrysophanic acid results in increased phosphorylation of EIF2S1 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

endoplasmic reticulum to nucleus signaling 1

increases expression

chrysophanic acid results in increased expression of ERN1 protein

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

mitogen-activated protein kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK1 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 14

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK14 protein

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK3 protein

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

proliferating cell nuclear antigen

decreases expression

chrysophanic acid results in decreased expression of PCNA protein

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

ribosomal protein S6

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6 protein

NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236

G

ribosomal protein S6 kinase B1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

solute carrier family 10 member 1

decreases expression

chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier family 22 member 6

decreases activity

chrysophanic acid results in decreased activity of SLC22A6 protein

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

decreases activity

chrysophanic acid results in decreased activity of SLC22A8 protein

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

G

sulfotransferase family 1A member 1

decreases activity

chrysophanic acid results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of chrysophanic acid

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

Citreorosein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily C member 19

increases chemical synthesis

CYP2C19 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 3 subfamily A member 4

increases chemical synthesis

CYP3A4 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

Disperse Blue 1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

H2A.X variant histone

increases phosphorylation

Disperse Blue 1 results in increased phosphorylation of H2AX protein

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

keratin 14

increases expression

Disperse Blue 1 results in increased expression of KRT14 protein

NCBI chr17:41,582,279...41,586,895
Ensembl chr17:41,582,279...41,586,895

emodin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions
increases expression

Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
Emodin results in increased expression of ABCB1A mRNA
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]

PMID:19549930 PMID:24380838

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 11

increases expression
multiple interactions
affects activity
decreases expression

Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside affects the reaction [[Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid]; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCB11 protein; [Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid
dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]
Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily B member 4

decreases expression

Emodin results in decreased expression of ABCB4 mRNA

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 2

increases expression
multiple interactions
decreases expression

Emodin results in increased expression of ABCC2 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC2 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC2 protein
Emodin results in decreased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein

PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions
decreases expression

Emodin results in increased expression of ABCC3 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC3 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC3 protein
Emodin results in decreased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein

PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily C member 4 (PEL blood group)

decreases expression
multiple interactions

Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC4 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

ATP binding cassette subfamily C member 6

increases expression

Emodin results in increased expression of ABCC6 mRNA

NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522

G

actin alpha 1, skeletal muscle

decreases expression

Emodin results in decreased expression of ACTA1 mRNA

NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Emodin results in decreased expression of ACTA2 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

PMID:15288473 PMID:27989784

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

adhesion G protein-coupled receptor E1

multiple interactions

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr19:6,887,579...6,940,450
Ensembl chr19:6,887,566...6,940,459

G

angiotensinogen

multiple interactions

Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

aryl hydrocarbon receptor

multiple interactions

Emodin binds to and results in increased activity of AHR protein
Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

PMID:14644660 PMID:17869316

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

aldo-keto reductase family 1 member B10

decreases activity

Emodin results in decreased activity of AKR1B10 protein

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C3

decreases activity

Emodin results in decreased activity of AKR1C3 protein

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

aldo-keto reductase family 7 member A3

decreases activity

Emodin results in decreased activity of AKR7A3 protein

NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
decreases expression

[Arsenic Trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
Emodin results in decreased expression of AKT1 mRNA

PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751

G

androgen receptor

multiple interactions

Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein]

NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619

G

arginase 2

decreases expression

Emodin results in decreased expression of ARG2 mRNA

NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708

G

AT-rich interaction domain 3A

increases expression

Emodin results in increased expression of ARID3A mRNA

NCBI chr19:925,732...975,939
Ensembl chr19:925,781...975,939

G

ATM serine/threonine kinase

increases expression
increases phosphorylation

Emodin results in increased expression of ATM mRNA
Emodin results in increased phosphorylation of ATM protein

PMID:16045814 PMID:20855424

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

G

BAG cochaperone 5

decreases expression

Emodin results in decreased expression of BAG5 mRNA

NCBI chr14:103,556,551...103,562,657
Ensembl chr14:103,556,545...103,562,657

G

BCL2 associated X, apoptosis regulator

affects expression
increases expression
multiple interactions
decreases expression

Emodin affects the expression of BAX protein
Emodin results in increased expression of BAX protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes the reaction [Emodin results in increased expression of BAX protein]
Emodin results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]

PMID:19549930 PMID:27032576 PMID:35753641

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression
multiple interactions
affects expression

Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of BCL2 protein
Emodin affects the expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]

PMID:19549930 PMID:23848338 PMID:27032576 PMID:35753641

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

bifunctional apoptosis regulator

decreases expression

Emodin results in decreased expression of BFAR mRNA

NCBI chr16:14,632,951...14,669,236
Ensembl chr16:14,632,931...14,669,236

G

BH3 interacting domain death agonist

increases degradation
multiple interactions

Emodin results in increased degradation of BID protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 5

decreases expression

Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

calnexin

decreases expression

Emodin results in decreased expression of CANX mRNA

NCBI chr 5:179,678,656...179,731,641
Ensembl chr 5:179,678,628...179,731,641

G

caspase 1

increases expression
multiple interactions

Emodin results in increased expression of CASP1 mRNA
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

PMID:15612046 PMID:37023836

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 12 (gene/pseudogene)

decreases expression

Emodin results in decreased expression of CASP12 mRNA

NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670

G

caspase 3

increases expression
multiple interactions
affects expression
increases cleavage
increases activity

Emodin results in increased expression of CASP3 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP3 protein; Emodin inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]
Emodin affects the expression of CASP3 protein modified form
Emodin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]

PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 PMID:34492313 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions
increases activity

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

increases expression
multiple interactions

Emodin results in increased expression of CASP9 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP9 protein

PMID:21319176 PMID:35753641

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions
affects expression

Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein]
Emodin affects the expression of CAT protein

PMID:19549930 PMID:22271272 PMID:26139382

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

carbonyl reductase 1

decreases activity

Emodin results in decreased activity of CBR1 protein

NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166

G

C-C motif chemokine ligand 26

multiple interactions

Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]

NCBI chr 7:75,769,524...75,791,597
Ensembl chr 7:75,769,533...75,789,896

G

cyclin B2

decreases expression

Emodin results in decreased expression of CCNB2 mRNA

NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045

G

C-C motif chemokine receptor 3

multiple interactions

Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]

NCBI chr 3:46,210,696...46,266,706
Ensembl chr 3:46,130,890...46,266,706

G

cadherin 1

multiple interactions
increases expression

2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]
Emodin results in increased expression of CDH1 protein

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

G

cyclin dependent kinase 13

decreases expression

Emodin results in decreased expression of CDK13 mRNA

NCBI chr 7:39,950,256...40,099,580
Ensembl chr 7:39,950,121...40,099,580

G

cyclin dependent kinase 4

decreases expression

Emodin results in decreased expression of CDK4 mRNA

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase inhibitor 1C

increases expression

Emodin results in increased expression of CDKN1C mRNA

NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775

G

cadherin EGF LAG seven-pass G-type receptor 3

decreases expression

Emodin results in decreased expression of CELSR3 mRNA

NCBI chr 3:48,636,463...48,662,886
Ensembl chr 3:48,636,463...48,662,886

G

chitinase acidic

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA]

NCBI chr 1:111,290,851...111,320,563
Ensembl chr 1:111,290,851...111,320,566

G

cell death inducing DFFA like effector c

decreases expression

Emodin results in decreased expression of CIDEC mRNA

NCBI chr 3:9,866,710...9,880,253
Ensembl chr 3:9,866,711...9,880,255

G

collagen type I alpha 1 chain

decreases expression

Emodin results in decreased expression of COL1A1 mRNA

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type I alpha 2 chain

multiple interactions

Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

collagen type III alpha 1 chain

decreases expression

Emodin results in decreased expression of COL3A1 mRNA

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

G

COP9 signalosome subunit 5

multiple interactions

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein

NCBI chr 8:67,043,079...67,062,133
Ensembl chr 8:67,043,079...67,083,783

G

casein kinase 2 alpha 1

increases expression

Emodin results in increased expression of CSNK2A1 mRNA

NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835

G

casein kinase 2 beta

increases expression

Emodin results in increased expression of CSNK2B mRNA

NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,227...31,670,343

G

cathepsin D

decreases expression

Emodin results in decreased expression of CTSD mRNA

NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573

G

C-X-C motif chemokine ligand 1

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 2

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA]

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

CYLD lysine 63 deubiquitinase

increases expression

Emodin results in increased expression of CYLD mRNA

NCBI chr16:50,742,086...50,801,935
Ensembl chr16:50,742,050...50,801,935

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions
decreases activity
increases expression

Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Emodin results in decreased activity of CYP1A1 protein
Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein

PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

increases oxidation
increases hydroxylation
decreases activity
multiple interactions

CYP1A2 protein results in increased oxidation of Emodin
CYP1A2 protein results in increased hydroxylation of Emodin
Emodin results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite

PMID:27633141 PMID:27989148 PMID:30672276 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 1 subfamily B member 1

increases expression
decreases activity

Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein
Emodin results in decreased activity of CYP1B1 protein

PMID:11502733 PMID:14990334 PMID:27633141

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 27 subfamily A member 1

decreases expression
multiple interactions

Emodin results in decreased expression of CYP27A1 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP27A1 protein

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293

G

cytochrome P450 family 2 subfamily C member 19

multiple interactions
decreases activity
increases oxidation

[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
Emodin results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased oxidation of Emodin

PMID:27989148 PMID:33438235

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

Emodin results in decreased activity of CYP2C9 protein

PMID:27633141 PMID:33438235

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily D member 6

decreases activity

Emodin results in decreased activity of CYP2D6 protein

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

cytochrome P450 family 3 subfamily A member 4

increases oxidation
decreases activity
affects response to substance
increases hydroxylation
multiple interactions

CYP3A4 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the susceptibility to Emodin
CYP3A4 protein results in increased hydroxylation of Emodin
[CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite

PMID:27989148 PMID:30672276 PMID:33438235 PMID:34875353

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 3 subfamily A member 5

increases hydroxylation

CYP3A5 protein results in increased hydroxylation of Emodin

NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP7A1 protein

PMID:28161596 PMID:35753641

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

Emodin results in decreased expression of CYP7B1 mRNA

NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein

NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898

G

dopachrome tautomerase

decreases expression

Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein

NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682

G

DNA damage inducible transcript 3

increases expression

Emodin results in increased expression of DDIT3 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

dihydrofolate reductase

decreases expression

Emodin results in decreased expression of DHFR mRNA

NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

Emodin results in increased expression of DNAJB1 mRNA

NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,514,769...14,560,391

G

dynein cytoplasmic 1 heavy chain 1

increases expression

Emodin results in increased expression of DYNC1H1 mRNA

NCBI chr14:101,964,573...102,056,443
Ensembl chr14:101,964,573...102,056,443

G

E2F transcription factor 5

increases expression

Emodin results in increased expression of E2F5 mRNA

NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158

G

early growth response 1

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA]

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

EI24 autophagy associated transmembrane protein

increases expression

Emodin results in increased expression of EI24 mRNA

NCBI chr11:125,569,477...125,584,684
Ensembl chr11:125,569,280...125,584,684

G

eukaryotic translation initiation factor 2B subunit alpha

decreases expression

Emodin results in decreased expression of EIF2B1 mRNA

NCBI chr12:123,620,406...123,633,686
Ensembl chr12:123,620,406...123,633,766

G

estrogen receptor 1

increases activity

Emodin results in increased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

estrogen receptor 2

increases activity

Emodin results in increased activity of ESR2 protein

NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112

G

fatty acid binding protein 5

decreases expression

Emodin results in decreased expression of FABP5 mRNA

NCBI chr 8:81,280,536...81,284,775
Ensembl chr 8:81,280,536...81,284,777

G

Fas associated via death domain

increases expression

Emodin results in increased expression of FADD mRNA

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

Fas cell surface death receptor

multiple interactions
decreases expression
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]
Emodin results in decreased expression of FAS protein

PMID:19549930 PMID:27032576

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein]

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

fibronectin 1

decreases expression

Emodin results in decreased expression of FN1 mRNA

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

forkhead box O1

increases expression

Emodin results in increased expression of FOXO1 mRNA

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

growth arrest and DNA damage inducible alpha

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA]

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

growth arrest specific 2

increases expression

Emodin results in increased expression of GAS2 mRNA

NCBI chr11:22,626,002...22,813,055
Ensembl chr11:22,625,509...22,813,001

G

glutamate-cysteine ligase catalytic subunit

increases expression

Emodin results in increased expression of GCLC mRNA

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

increases expression

Emodin results in increased expression of GCLM mRNA

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

glucosaminyl (N-acetyl) transferase 2 (I blood group)

increases expression

Emodin results in increased expression of GCNT2 mRNA

NCBI chr 6:10,521,351...10,629,368
Ensembl chr 6:10,492,223...10,629,368

G

glial fibrillary acidic protein

multiple interactions

Emodin inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

golgin A3

increases expression

Emodin results in increased expression of GOLGA3 mRNA

NCBI chr12:132,768,914...132,829,081
Ensembl chr12:132,768,902...132,829,143

G

glutamic--pyruvic transaminase

multiple interactions

[Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

PMID:34492313 PMID:37023836

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione peroxidase 1

increases expression

Emodin results in increased expression of GPX1 mRNA

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 2

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA]

NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746

G

glutathione-disulfide reductase

multiple interactions

Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein]

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione S-transferase mu 3

decreases expression

Emodin results in decreased expression of GSTM3 mRNA

NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038

G

glutathione S-transferase pi 1

multiple interactions

Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

H1.9 linker histone, pseudogene

increases expression

Emodin results in increased expression of H1F9 mRNA

NCBI chr17:50,171,428...50,172,476
Ensembl chr17:50,171,514...50,171,936

G

H2A.X variant histone

increases expression
multiple interactions

Emodin results in increased expression of H2AX protein; Emodin results in increased expression of H2AX protein modified form
TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]

PMID:20855424 PMID:34492313 PMID:36893906

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

3-hydroxyacyl-CoA dehydratase 3

decreases expression

Emodin results in decreased expression of HACD3 mRNA

NCBI chr15:65,530,463...65,578,349
Ensembl chr15:65,530,418...65,578,349

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA]

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

hexokinase 2

increases expression

Emodin results in increased expression of HK2 mRNA

NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359

G

heme oxygenase 1

multiple interactions
increases expression

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein]
Emodin results in increased expression of HMOX1 mRNA

PMID:26139382 PMID:30517764 PMID:34875353

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

hepatocyte nuclear factor 4 alpha

affects glucuronidation
decreases expression

HNF4A gene SNP affects the glucuronidation of Emodin
Emodin results in decreased expression of HNF4A protein
Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein

NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845

G

heat shock protein family A (Hsp70) member 5

increases expression

Emodin results in increased expression of HSPA5 protein

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

intercellular adhesion molecule 1

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interferon alpha 2

multiple interactions

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein; [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein

NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398

G

immunoglobulin superfamily member 11

increases expression

Emodin results in increased expression of IGSF11 mRNA

NCBI chr 3:118,900,557...119,146,020
Ensembl chr 3:118,900,557...119,146,068

G

interleukin 10

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA]

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 13

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein]

NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110

G

interleukin 15

increases expression

Emodin results in increased expression of IL15 mRNA

NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987

G

interleukin 18

multiple interactions

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 beta

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein]
Emodin inhibits the reaction [Oxaliplatin results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]

PMID:26139382 PMID:30517764 PMID:36184831 PMID:37023836

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 4

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 5

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]

NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838

G

interleukin 6

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 PMID:37023836

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

inositol 1,4,5-trisphosphate receptor type 1

decreases expression

Emodin results in decreased expression of ITPR1 mRNA

NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506

G

jagged canonical Notch ligand 1

decreases expression
multiple interactions

Emodin results in decreased expression of JAG1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]

NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999

G

Janus kinase 1

decreases phosphorylation
multiple interactions

Emodin results in decreased phosphorylation of JAK1 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]

NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754

G

Janus kinase 2

decreases phosphorylation
multiple interactions

Emodin results in decreased phosphorylation of JAK2 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein

NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622

G

keratin 19

decreases expression

Emodin results in decreased expression of KRT19 mRNA

NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308

G

lysosomal protein transmembrane 5

increases expression

Emodin results in increased expression of LAPTM5 mRNA

NCBI chr 1:30,732,469...30,757,774
Ensembl chr 1:30,732,469...30,757,774

G

lymphoid enhancer binding factor 1

decreases expression

Emodin results in decreased expression of LEF1 mRNA

NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956

G

LDL receptor related protein 1

multiple interactions

[Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein

NCBI chr12:57,128,483...57,213,361
Ensembl chr12:57,128,483...57,213,361

G

microtubule actin crosslinking factor 1

decreases expression

Emodin results in decreased expression of MACF1 mRNA

NCBI chr 1:39,084,167...39,487,138
Ensembl chr 1:39,081,316...39,487,177

G

monoamine oxidase B

decreases activity

Emodin results in decreased activity of MAOB protein

NCBI chr X:43,766,610...43,882,450
Ensembl chr X:43,766,610...43,882,450

G

mitogen-activated protein kinase kinase 1

multiple interactions

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

mitogen-activated protein kinase kinase 2

multiple interactions

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]

NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122

G

mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
Emodin results in decreased phosphorylation of MAPK1 protein
Emodin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]

PMID:15288473 PMID:26972667 PMID:27032576

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 10

increases expression

Emodin results in increased expression of MAPK10 mRNA

NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625

G

mitogen-activated protein kinase 14

multiple interactions

Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236

G

mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
Emodin results in decreased phosphorylation of MAPK3 protein
Emodin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]

PMID:15288473 PMID:26972667 PMID:27032576

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

microtubule associated protein tau

decreases expression

Emodin results in decreased expression of MAPT mRNA

NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
increases expression

Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein
Emodin results in increased expression of MCL1 mRNA

PMID:21319176 PMID:23848338

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

maternal embryonic leucine zipper kinase

decreases expression

Emodin results in decreased expression of MELK mRNA; Emodin results in decreased expression of MELK protein

NCBI chr 9:36,572,895...36,677,682
Ensembl chr 9:36,572,862...36,677,683

G

O-6-methylguanine-DNA methyltransferase

increases expression

Emodin results in increased expression of MGMT mRNA

NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983

G

melanocyte inducing transcription factor

decreases expression

Emodin results in decreased expression of MITF protein

NCBI chr 3:69,739,464...69,968,332
Ensembl chr 3:69,739,456...69,968,336

G

myeloperoxidase

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
affects expression

Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]
Emodin affects the expression of MYC protein

PMID:17886230 PMID:19549930

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

myosin light chain kinase

increases activity

Emodin results in increased activity of MYLK protein

NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332

G

nuclear receptor coactivator 2

increases expression

Emodin results in increased expression of NCOA2 mRNA

NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization

Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA]
[[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]
Emodin affects the localization of NFE2L2 protein

PMID:26139382 PMID:34971761

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions

Emodin results in increased expression of NFKB1 protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]

PMID:19549930 PMID:37023836

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

increases expression
multiple interactions

Emodin results in increased expression of NFKBIA mRNA
Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

PMID:16045814 PMID:22484343

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NK6 homeobox 2

increases expression

Emodin results in increased expression of NKX6-2 mRNA

NCBI chr10:132,783,181...132,786,147
Ensembl chr10:132,783,179...132,786,147

G

NLR family pyrin domain containing 3

multiple interactions

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

nitric oxide synthase 2

multiple interactions
affects expression

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]
Emodin affects the expression of NOS2

PMID:18590720 PMID:23615023

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

notch receptor 1

decreases expression
decreases response to substance
multiple interactions

Emodin results in decreased expression of NOTCH1 protein
NOTCH1 protein results in decreased susceptibility to Emodin
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]

NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Emodin results in increased expression of NQO1 mRNA
Emodin results in increased expression of and results in increased activity of NQO1 protein

PMID:34875353 PMID:34971761

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 0 group B member 2

increases expression

Emodin results in increased expression of NR0B2 mRNA

NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975

G

nuclear receptor subfamily 1 group H member 3

increases expression

Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein

NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033

G

nuclear receptor subfamily 1 group H member 4

decreases expression

Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein

NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414

G

OMA1 zinc metallopeptidase

multiple interactions

Emodin inhibits the reaction [Hydrogen Peroxide results in increased expression of OMA1 protein]; Emodin inhibits the reaction [Oxidopamine results in increased expression of OMA1 protein]

NCBI chr 1:58,480,719...58,546,726
Ensembl chr 1:58,415,384...58,546,802

G

poly(ADP-ribose) polymerase 1

increases activity
increases cleavage
multiple interactions

Emodin results in increased activity of PARP1 protein
Emodin results in increased cleavage of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]

PMID:23848338 PMID:27032576 PMID:34492313 PMID:36893906

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

proliferating cell nuclear antigen

multiple interactions

Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

phosducin like

decreases expression

Emodin results in decreased expression of PDCL mRNA

NCBI chr 9:122,818,097...122,828,588
Ensembl chr 9:122,798,389...122,828,588

G

platelet derived growth factor subunit B

multiple interactions

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]

NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982

G

platelet derived growth factor receptor beta

multiple interactions
decreases expression

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Emodin results in decreased expression of PDGFRB protein

NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872

G

platelet and endothelial cell adhesion molecule 1

decreases expression

Emodin results in decreased expression of PECAM1 protein

NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776

G

phosphatidylinositol 3-kinase catalytic subunit type 3

increases expression

Emodin results in increased expression of PIK3C3 mRNA

NCBI chr18:41,955,234...42,087,830
Ensembl chr18:41,955,234...42,087,830

G

phosphoinositide-3-kinase regulatory subunit 1

affects expression

Emodin affects the expression of PIK3R1 protein

NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821

G

pyruvate kinase M1/2

decreases activity
affects localization
multiple interactions

Emodin results in decreased activity of PKM protein
Emodin affects the localization of PKM protein
[[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which results in decreased activity of PKM protein; [Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

peroxisome proliferator activated receptor gamma

increases expression
multiple interactions

Emodin results in increased expression of PPARG protein
Emodin results in increased stability of and results in increased expression of PPARG mRNA

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein phosphatase, Mg2+/Mn2+ dependent 1D

increases expression

Emodin results in increased expression of PPM1D mRNA

NCBI chr17:60,600,193...60,666,280
Ensembl chr17:60,600,193...60,666,280

G

protein phosphatase 1 regulatory inhibitor subunit 1C

decreases expression

Emodin results in decreased expression of PPP1R1C mRNA

NCBI chr 2:181,954,480...182,131,385
Ensembl chr 2:181,954,241...182,131,398

G

peroxiredoxin 6

increases expression

Emodin results in increased expression of PRDX6 mRNA

NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815

G

protein kinase C alpha

affects localization

Emodin affects the localization of PRKCA protein

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

G

protein kinase C delta

decreases expression
affects expression

Emodin results in decreased expression of PRKCD mRNA
Emodin affects the expression of PRKCD protein

PMID:16045814 PMID:19549930

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

G

protamine 3

increases expression

Emodin results in increased expression of PRM3 mRNA

NCBI chr16:11,273,199...11,273,629
Ensembl chr16:11,273,199...11,273,629

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Emodin inhibits the reaction [Oxaliplatin results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine kinase 2

affects expression

Emodin affects the expression of PTK2 protein

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

protein tyrosine phosphatase non-receptor type 6

increases expression
multiple interactions

Emodin results in increased expression of PTPN6 protein
PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression
multiple interactions

Emodin results in decreased expression of RAF1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]

PMID:15288473 PMID:16045814

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

recombination activating 1

decreases expression

Emodin results in decreased expression of RAG1 mRNA

NCBI chr11:36,510,353...36,579,762
Ensembl chr11:36,510,372...36,593,156

G

retinoic acid receptor beta

decreases expression

Emodin results in decreased expression of RARB mRNA

NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932

G

RB transcriptional corepressor 1

decreases expression

Emodin results in decreased expression of RB1 mRNA

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

reticulocalbin 2

increases expression

Emodin results in increased expression of RCN2 mRNA

NCBI chr15:76,931,749...76,954,393
Ensembl chr15:76,931,738...76,954,393

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases localization

Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of RELA protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin results in decreased localization of RELA protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]; Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]

PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 PMID:36184831 More...

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

ras homolog family member A

decreases expression

Emodin results in decreased expression of RHOA mRNA

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

Rho associated coiled-coil containing protein kinase 1

decreases expression

Emodin results in decreased expression of ROCK1 mRNA

NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813

G

Rho associated coiled-coil containing protein kinase 2

decreases expression

Emodin results in decreased expression of ROCK2 mRNA

NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330

G

SUMO1 activating enzyme subunit 1

decreases expression

Emodin results in decreased expression of SAE1 mRNA

NCBI chr19:47,130,835...47,210,636
Ensembl chr19:47,113,274...47,210,636

G

serpin family E member 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

solute carrier family 10 member 1

decreases expression
multiple interactions

Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]

PMID:28161596 PMID:30517764

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier family 22 member 6

decreases activity

Emodin results in decreased activity of SLC22A6 protein

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

decreases activity

Emodin results in decreased activity of SLC22A8 protein

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

G

solute carrier organic anion transporter family member 1B3

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

G

sperm mitochondria associated cysteine rich protein

increases expression

Emodin results in increased expression of SMCP mRNA

NCBI chr 1:152,878,322...152,885,047
Ensembl chr 1:152,878,322...152,885,047

G

small nuclear ribonucleoprotein 13

decreases expression

Emodin results in decreased expression of SNU13 mRNA

NCBI chr22:41,673,933...41,690,480
Ensembl chr22:41,673,933...41,690,504

G

superoxide dismutase 1

multiple interactions

Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA]

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

multiple interactions
affects activity

Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]
Emodin affects the activity of SOD2 protein

PMID:21382473 PMID:23615023

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation

Emodin results in decreased phosphorylation of SRC protein

NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

increases expression

Emodin results in increased expression of ST8SIA1 mRNA

NCBI chr12:22,193,391...22,334,707
Ensembl chr12:22,063,773...22,437,041

G

signal transducer and activator of transcription 3

affects localization
multiple interactions

Emodin affects the localization of STAT3 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

stress induced phosphoprotein 1

decreases expression

Emodin results in decreased expression of STIP1 mRNA

NCBI chr11:64,185,272...64,204,543
Ensembl chr11:64,185,272...64,204,543

G

sulfotransferase family 1A member 1

decreases activity

Emodin results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

SPT20 homolog, SAGA complex component

increases expression

Emodin results in increased expression of SUPT20H mRNA

NCBI chr13:37,009,312...37,059,688
Ensembl chr13:37,009,312...37,059,713

G

TAO kinase 3

decreases expression

Emodin results in decreased expression of TAOK3 mRNA

NCBI chr12:118,149,801...118,372,907
Ensembl chr12:118,149,801...118,372,907

G

tubulin folding cofactor C

decreases expression

Emodin results in decreased expression of TBCC mRNA

NCBI chr 6:42,744,498...42,746,103
Ensembl chr 6:42,744,498...42,746,103

G

transcription factor like 5

increases expression

Emodin results in increased expression of TCFL5 mRNA

NCBI chr20:62,841,005...62,861,822
Ensembl chr20:62,841,005...62,861,822

G

transforming growth factor beta 1

multiple interactions
decreases activity

2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]

PMID:15288473 PMID:19474275 PMID:27989784

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]

PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 PMID:36184831 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

DNA topoisomerase II alpha

multiple interactions
increases activity

Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
Emodin results in increased activity of TOP2A protein

NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896

G

tumor protein p53

affects expression

Emodin affects the expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tumor protein p63

increases expression

Emodin results in increased expression of TRP63 mRNA

NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276

G

TNF receptor associated factor 2

increases expression
decreases expression

Emodin results in increased expression of TRAF2 mRNA
Emodin results in decreased expression of TRAF2 mRNA

PMID:16045814 PMID:21319176

NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607

G

transient receptor potential cation channel subfamily V member 2

increases expression

Emodin results in increased expression of TRPV2 mRNA

NCBI chr17:16,415,571...16,437,003
Ensembl chr17:16,415,571...16,437,003

G

testis specific 13

increases expression

Emodin results in increased expression of TSGA13 mRNA

NCBI chr 7:130,668,643...130,687,432
Ensembl chr 7:130,668,643...130,687,432

G

tubulin beta 3 class III

decreases expression

Emodin results in decreased expression of TUBB3 mRNA

NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761

G

thioredoxin

multiple interactions

Emodin results in increased expression of and results in increased activity of TXN protein

NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507

G

thioredoxin like 4B

decreases expression

Emodin results in decreased expression of TXNL4B mRNA

NCBI chr16:72,084,857...72,094,378
Ensembl chr16:72,044,289...72,094,431

G

thioredoxin reductase 1

decreases expression
multiple interactions

Emodin results in decreased expression of TXNRD1 mRNA
Emodin results in increased expression of and results in increased activity of TXNRD1 protein

PMID:16045814 PMID:34971761

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

tyrosinase

decreases activity

Emodin results in decreased activity of TYR protein

NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759

G

tyrosinase related protein 1

decreases expression

Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein

NCBI chr 9:12,693,385...12,710,285
Ensembl chr 9:12,685,439...12,710,285

G

ubiquitin conjugating enzyme E2 I

increases expression

Emodin results in increased expression of UBE2I mRNA

NCBI chr16:1,309,152...1,327,017
Ensembl chr16:1,291,444...1,327,018

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of Emodin

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of Emodin

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of Emodin

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of Emodin

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Emodin

PMID:14557274 PMID:24854283

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of Emodin

NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652

G

UDP glucuronosyltransferase family 2 member B7

decreases expression

Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein

NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987

G

voltage dependent anion channel 1

decreases expression

Emodin results in decreased expression of VDAC1 mRNA

NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975

G

vascular endothelial growth factor A

decreases expression

Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

vimentin

decreases expression
multiple interactions

Emodin results in decreased expression of VIM protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

X-ray repair cross complementing 1

affects expression

Emodin affects the expression of XRCC1 protein

NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473

G

ZFP37 zinc finger protein

increases expression

Emodin results in increased expression of ZFP37 mRNA

NCBI chr 9:113,038,377...113,056,724
Ensembl chr 9:113,038,377...113,056,759

Frangulin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B10

decreases activity

frangulin A results in decreased activity of AKR1B10 protein

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C3

decreases activity

frangulin A results in decreased activity of AKR1C3 protein

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

carbonyl reductase 1

decreases activity

frangulin A results in decreased activity of CBR1 protein

NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions

[frangulin A co-treated with frangulin B] results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

Frangulin B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B10

decreases activity

frangulin B results in decreased activity of AKR1B10 protein

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C3

decreases activity

frangulin B results in decreased activity of AKR1C3 protein

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

carbonyl reductase 1

decreases activity

frangulin B results in decreased activity of CBR1 protein

NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166

G

cytochrome P450 family 1 subfamily A member 2

multiple interactions

[frangulin A co-treated with frangulin B] results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

Macrosporin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DNA topoisomerase II alpha

decreases activity

macrosporin results in decreased activity of TOP2A protein

NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896

mitoxantrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

affects response to substance

ABCA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155

G

ATP binding cassette subfamily B member 1

increases expression

Mitoxantrone results in increased expression of ABCB1 protein

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily G member 2 (JR blood group)

affects export
affects response to substance
increases transport
multiple interactions
increases export
increases expression
decreases abundance
decreases response to substance
affects uptake
affects transport
increases response to substance

ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the susceptibility to Mitoxantrone
ABCG2 protein results in increased transport of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in decreased abundance of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone

PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More...

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

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acyl-CoA dehydrogenase very long chain

decreases expression

Mitoxantrone results in decreased expression of ACADVL protein

NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266

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acyl-CoA synthetase long chain family member 3

affects response to substance

ACSL3 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639

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actin alpha 1, skeletal muscle

decreases expression

Mitoxantrone results in decreased expression of ACTA1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104

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actin gamma 2, smooth muscle

affects response to substance

ACTG2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865

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adenosine deaminase RNA specific B1

affects response to substance

ADARB1 protein affects the susceptibility to Mitoxantrone

NCBI chr21:45,074,578...45,226,563
Ensembl chr21:45,073,853...45,226,560

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1-acylglycerol-3-phosphate O-acyltransferase 5

affects response to substance

AGPAT5 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:6,708,642...6,761,503
Ensembl chr 8:6,708,642...6,761,503

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adenosylhomocysteinase like 1

affects response to substance

AHCYL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742

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aldehyde dehydrogenase 2 family member

affects response to substance

ALDH2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532

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angiomotin like 1

affects response to substance

AMOTL1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr11:94,706,460...94,876,748
Ensembl chr11:94,706,431...94,876,748

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ankyrin 2

decreases expression

Mitoxantrone results in decreased expression of ANK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221

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apolipoprotein B mRNA editing enzyme catalytic subunit 3C

affects response to substance

APOBEC3C protein affects the susceptibility to Mitoxantrone

NCBI chr22:39,014,257...39,020,352
Ensembl chr22:39,014,257...39,020,352

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asparagine synthetase (glutamine-hydrolyzing)

affects response to substance

ASNS protein affects the susceptibility to Mitoxantrone

NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542

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argininosuccinate synthase 1

affects response to substance

ASS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274

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autophagy related 5

decreases expression

Mitoxantrone results in decreased expression of ATG5 protein

NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791

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ATM serine/threonine kinase

decreases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in decreased expression of ATM mRNA
Mitoxantrone results in increased phosphorylation of ATM protein
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein

PMID:22832221 PMID:29913208

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102

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ATPase Na+/K+ transporting subunit alpha 2

decreases expression

Mitoxantrone results in decreased expression of ATP1A2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591

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ATP synthase F1 subunit alpha

decreases expression

Mitoxantrone results in decreased expression of ATP5F1A protein

NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334

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ATP synthase F1 subunit beta

decreases expression

Mitoxantrone results in decreased expression of ATP5F1B protein

NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984

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ATP synthase F1 subunit gamma

decreases expression

Mitoxantrone results in decreased expression of ATP5F1C protein

NCBI chr10:7,788,177...7,807,801
Ensembl chr10:7,788,147...7,807,815

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ATPase copper transporting alpha

decreases response to substance

ATP7A protein results in decreased susceptibility to Mitoxantrone

NCBI chr X:77,910,693...78,050,395
Ensembl chr X:77,910,690...78,050,395

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beta-secretase 2

affects response to substance

BACE2 protein affects the susceptibility to Mitoxantrone

NCBI chr21:41,168,160...41,282,530
Ensembl chr21:41,167,801...41,282,530

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BCL2 associated X, apoptosis regulator

increases expression

Mitoxantrone results in increased expression of BAX mRNA

PMID:26537877 PMID:28940058

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

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BBX high mobility group box domain containing

affects response to substance

BBX protein affects the susceptibility to Mitoxantrone

NCBI chr 3:107,522,962...107,811,339
Ensembl chr 3:107,522,936...107,811,339

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basal cell adhesion molecule (Lutheran blood group)

affects response to substance

BCAM protein affects the susceptibility to Mitoxantrone

NCBI chr19:44,809,059...44,821,421
Ensembl chr19:44,809,071...44,821,421

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branched chain amino acid transaminase 1

increases expression

Mitoxantrone results in increased expression of BCAT1 mRNA

NCBI chr12:24,810,024...24,949,340
Ensembl chr12:24,810,024...24,949,101

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BCL2 apoptosis regulator

multiple interactions
decreases expression

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA

PMID:8219202 PMID:8840993 PMID:15582267

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

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BCL2 like 1

multiple interactions

BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

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beclin 1

decreases expression

Mitoxantrone results in decreased expression of BECN1 protein

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

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baculoviral IAP repeat containing 2

decreases expression

Mitoxantrone results in decreased expression of BIRC2 protein

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

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baculoviral IAP repeat containing 5

affects expression
increases expression

Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

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bone morphogenetic protein 7

affects response to substance

BMP7 protein affects the susceptibility to Mitoxantrone

NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641

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bone marrow stromal cell antigen 2

affects response to substance

BST2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630

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BTB domain containing 3

affects response to substance

BTBD3 protein affects the susceptibility to Mitoxantrone

NCBI chr20:11,890,817...11,926,595
Ensembl chr20:11,890,723...11,926,609

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calcium voltage-gated channel subunit alpha1 G

decreases expression

Mitoxantrone results in decreased expression of CACNA1G mRNA

PMID:26537877 PMID:28940058

NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474

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calcium voltage-gated channel auxiliary subunit alpha2delta 2

decreases expression

Mitoxantrone results in decreased expression of CACNA2D2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:50,362,613...50,504,244
Ensembl chr 3:50,362,613...50,504,244

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calreticulin

affects localization

Mitoxantrone affects the localization of CALR protein

NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489

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calcium/calmodulin dependent protein kinase II inhibitor 1

affects response to substance

CAMK2N1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:20,482,391...20,486,210
Ensembl chr 1:20,482,391...20,486,210

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CASC3 exon junction complex subunit

affects response to substance

CASC3 mRNA affects the susceptibility to Mitoxantrone

NCBI chr17:40,140,537...40,172,171
Ensembl chr17:40,140,318...40,172,171

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caspase 2

increases expression
increases splicing

Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA

NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696

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caspase 3

multiple interactions
increases activity

BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]

PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

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caspase 6

increases activity

Mitoxantrone results in increased activity of CASP6 protein

NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583

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caspase 7

increases activity
multiple interactions

Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]

PMID:12948851 PMID:22700542

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

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caspase 8

increases activity

Mitoxantrone results in increased activity of CASP8 protein

PMID:12948851 PMID:32894303

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

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caspase 9

increases activity

Mitoxantrone results in increased activity of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

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catalase

decreases activity

Mitoxantrone results in decreased activity of CAT protein

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

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caveolae associated protein 3

affects response to substance

CAVIN3 protein affects the susceptibility to Mitoxantrone

NCBI chr11:6,318,946...6,320,501
Ensembl chr11:6,318,946...6,320,532

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caveolae associated protein 4

decreases expression

Mitoxantrone results in decreased expression of CAVIN4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 9:100,576,867...100,588,389
Ensembl chr 9:100,578,079...100,588,389

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CD55 molecule (Cromer blood group)

affects response to substance

CD55 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804

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CD58 molecule

affects response to substance

CD58 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:116,514,534...116,571,026
Ensembl chr 1:116,514,534...116,571,039

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CUGBP Elav-like family member 2

affects response to substance

CELF2 protein affects the susceptibility to Mitoxantrone

NCBI chr10:10,462,550...11,336,675
Ensembl chr10:10,798,397...11,336,675

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centrosomal protein 15

affects response to substance

CEP15 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:62,319,022...62,336,213
Ensembl chr 3:62,319,015...62,336,213

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carboxylesterase 2

affects response to substance

CES2 protein affects the susceptibility to Mitoxantrone

NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096

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chordin like 1

affects response to substance

CHRDL1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:110,673,856...110,795,817
Ensembl chr X:110,673,856...110,795,819

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chemokine like factor

affects response to substance

CKLF protein affects the susceptibility to Mitoxantrone

NCBI chr16:66,552,563...66,566,287
Ensembl chr16:66,552,563...66,566,251

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creatine kinase, M-type

decreases expression

Mitoxantrone results in decreased expression of CKM mRNA

PMID:26537877 PMID:28940058

NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875

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chloride nucleotide-sensitive channel 1A

affects response to substance

CLNS1A protein affects the susceptibility to Mitoxantrone

NCBI chr11:77,614,530...77,637,794
Ensembl chr11:77,514,936...77,637,794

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clusterin

affects response to substance

CLU protein affects the susceptibility to Mitoxantrone

NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700

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cochlin

affects response to substance

COCH protein affects the susceptibility to Mitoxantrone

NCBI chr14:30,874,559...30,895,615
Ensembl chr14:30,874,514...30,895,065

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collagen type XI alpha 1 chain

affects response to substance

COL11A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:102,876,473...103,108,522
Ensembl chr 1:102,876,467...103,108,872

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corin, serine peptidase

decreases expression

Mitoxantrone results in decreased expression of CORIN mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:47,594,001...47,838,067
Ensembl chr 4:47,593,999...47,838,106

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carboxypeptidase vitellogenic like

affects response to substance

CPVL protein affects the susceptibility to Mitoxantrone

NCBI chr 7:28,994,636...29,195,451
Ensembl chr 7:28,995,235...29,195,451

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cAMP responsive element binding protein like 2

affects response to substance

CREBL2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:12,611,876...12,645,108
Ensembl chr12:12,611,827...12,645,108

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citrate synthase

decreases activity

Mitoxantrone results in decreased activity of CS protein

NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391

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cysteine and serine rich nuclear protein 2

affects response to substance

CSRNP2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr12:51,061,205...51,083,596
Ensembl chr12:51,061,205...51,083,664

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cystathionine gamma-lyase

affects response to substance

CTH protein affects the susceptibility to Mitoxantrone

NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851

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CXADR Ig-like cell adhesion molecule

affects response to substance

CXADR protein affects the susceptibility to Mitoxantrone

NCBI chr21:17,513,043...17,636,262
Ensembl chr21:17,513,043...17,593,579

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cytochrome P450 family 1 subfamily A member 1

decreases activity

Mitoxantrone results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

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cytochrome P450 family 1 subfamily B member 1

decreases activity

Mitoxantrone results in decreased activity of CYP1B1 protein

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

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death associated protein kinase 1

affects response to substance

DAPK1 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:87,497,228...87,708,634
Ensembl chr 9:87,497,228...87,708,634

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DNA damage inducible transcript 4

affects response to substance

DDIT4 protein affects the susceptibility to Mitoxantrone

NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036

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dehydrogenase/reductase 2

affects response to substance

DHRS2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639

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DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

affects response to substance

DIS3 protein affects the susceptibility to Mitoxantrone

NCBI chr13:72,752,169...72,781,900
Ensembl chr13:72,752,169...72,782,096

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dystrophin

decreases expression

Mitoxantrone results in decreased expression of DMD mRNA

PMID:26537877 PMID:28940058

NCBI chr X:31,119,222...33,339,388
Ensembl chr X:31,097,677...33,339,609

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dual specificity phosphatase 4

affects response to substance
increases expression

DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA

PMID:16217747 PMID:26537877 PMID:28940058

NCBI chr 8:29,333,064...29,350,684
Ensembl chr 8:29,333,064...29,350,684

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dual specificity tyrosine phosphorylation regulated kinase 2

affects response to substance

DYRK2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:67,648,745...67,665,406
Ensembl chr12:67,648,338...67,665,406

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early growth response 1

affects response to substance

EGR1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

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eukaryotic translation initiation factor 2 subunit alpha

affects response to substance

EIF2S1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

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eukaryotic translation initiation factor 5A

affects response to substance

EIF5A protein affects the susceptibility to Mitoxantrone

NCBI chr17:7,306,999...7,312,463
Ensembl chr17:7,306,999...7,312,463

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ELAV like RNA binding protein 4

affects response to substance

ELAVL4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:50,048,055...50,203,772
Ensembl chr 1:50,024,029...50,203,772

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ELOVL fatty acid elongase 5

affects response to substance

ELOVL5 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:53,267,404...53,348,950
Ensembl chr 6:53,267,398...53,349,179

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engrailed homeobox 2

affects response to substance

EN2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:155,458,129...155,464,831
Ensembl chr 7:155,458,129...155,464,831

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ectodermal-neural cortex 1

affects response to substance

ENC1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424

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erythrocyte membrane protein band 4.1 like 2

affects response to substance

EPB41L2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:130,839,347...131,063,245
Ensembl chr 6:130,839,347...131,063,322

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erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

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erb-b2 receptor tyrosine kinase 3

decreases expression

Mitoxantrone results in decreased expression of ERBB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505

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electron transfer flavoprotein dehydrogenase

decreases expression

Mitoxantrone results in decreased expression of ETFDH protein

NCBI chr 4:158,672,296...158,709,623
Ensembl chr 4:158,671,968...158,710,742

G

ecotropic viral integration site 5

affects response to substance

EVI5 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:92,508,696...92,792,410
Ensembl chr 1:92,508,696...92,792,404

G

exostosin like glycosyltransferase 2

affects response to substance

EXTL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:100,872,372...100,895,179
Ensembl chr 1:100,872,372...100,895,179

G

fatty acid binding protein 3

increases expression

Mitoxantrone results in increased expression of FABP3 protein

NCBI chr 1:31,359,588...31,373,076
Ensembl chr 1:31,365,253...31,376,850

G

family with sequence similarity 117 member A

affects response to substance

FAM117A protein affects the susceptibility to Mitoxantrone

NCBI chr17:49,710,332...49,789,110
Ensembl chr17:49,710,332...49,789,180

G

Fas cell surface death receptor

multiple interactions
increases expression

Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein

PMID:9676859 PMID:26537877 PMID:28940058

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

fatty acid synthase

decreases response to substance
multiple interactions

FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

farnesyl-diphosphate farnesyltransferase 1

affects response to substance

FDFT1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395

G

four and a half LIM domains 1

increases expression

Mitoxantrone results in increased expression of FHL1 mRNA

NCBI chr X:136,146,702...136,211,359
Ensembl chr X:136,146,702...136,211,359

G

fibronectin leucine rich transmembrane protein 3

affects response to substance

FLRT3 protein affects the susceptibility to Mitoxantrone

NCBI chr20:14,322,985...14,337,612
Ensembl chr20:14,322,985...14,337,614

G

fibronectin type III domain containing 3A

affects response to substance

FNDC3A protein affects the susceptibility to Mitoxantrone

NCBI chr13:48,975,291...49,209,779
Ensembl chr13:48,975,912...49,209,779

G

forkhead box F2

affects response to substance

FOXF2 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:1,389,576...1,395,603
Ensembl chr 6:1,389,576...1,395,603

G

FYN proto-oncogene, Src family tyrosine kinase

affects response to substance

FYN protein affects the susceptibility to Mitoxantrone

NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452

G

frizzled class receptor 2

affects response to substance

FZD2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262

G

G antigen 2A

affects response to substance

GAGE2A protein affects the susceptibility to Mitoxantrone

NCBI chr X:49,589,496...49,596,824
Ensembl chr X:49,589,496...49,596,824

G

G antigen 4

affects response to substance

GAGE4 protein affects the susceptibility to Mitoxantrone

G

G antigen 6

affects response to substance

GAGE6 protein affects the susceptibility to Mitoxantrone

G

G antigen 7

affects response to substance

GAGE7 protein affects the susceptibility to Mitoxantrone

Ensembl chr X:49,551,278...49,568,218
Ensembl chr X:49,551,278...49,568,218

G

GTP cyclohydrolase 1

affects response to substance

GCH1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826

G

growth differentiation factor 15

increases expression

Mitoxantrone results in increased expression of GDF15 mRNA

PMID:26537877 PMID:28940058

NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176

G

glutamate-ammonia ligase

affects response to substance

GLUL protein affects the susceptibility to Mitoxantrone

NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206

G

glutathione peroxidase 1

increases expression

Mitoxantrone results in increased expression of GPX1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 3

affects response to substance

GPX3 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988

G

guanylate cyclase 1 soluble subunit beta 1

affects response to substance

GUCY1B1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811

G

H2A.X variant histone

increases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in increased expression of H2AX protein
Mitoxantrone results in increased phosphorylation of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]

PMID:19738048 PMID:24994473 PMID:29913208

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

decreases expression

Mitoxantrone results in decreased expression of HADHB protein

NCBI chr 2:26,244,939...26,290,465
Ensembl chr 2:26,243,170...26,290,465

G

histone deacetylase 4

affects response to substance

HDAC4 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654

G

major histocompatibility complex, class II, DR beta 5

affects response to substance

HLA-DRB5 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:32,517,353...32,530,287
Ensembl chr 6:32,517,353...32,530,287

G

high mobility group 20B

affects response to substance

HMG20B protein affects the susceptibility to Mitoxantrone

NCBI chr19:3,572,944...3,579,083
Ensembl chr19:3,572,777...3,579,088

G

homeobox A5

affects response to substance

HOXA5 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:27,141,052...27,143,681
Ensembl chr 7:27,141,052...27,143,681

G

histidine rich calcium binding protein

decreases expression

Mitoxantrone results in decreased expression of HRC mRNA

PMID:26537877 PMID:28940058

NCBI chr19:49,151,198...49,155,396
Ensembl chr19:49,151,198...49,155,396

G

heat shock protein family A (Hsp70) member 2

affects response to substance

HSPA2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects response to substance
decreases expression

IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein

PMID:16217747 PMID:34246718

NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945

G

interferon induced transmembrane protein 1

affects response to substance

IFITM1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:314,040...315,272
Ensembl chr11:310,041...315,272

G

insulin like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Mitoxantrone

NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530

G

insulin like growth factor 2 mRNA binding protein 3

affects response to substance

IGF2BP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:23,310,209...23,470,491
Ensembl chr 7:23,310,209...23,470,491

G

insulin like growth factor binding protein 3

affects response to substance

IGFBP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874

G

insulin like growth factor binding protein 7

affects response to substance

IGFBP7 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:57,030,773...57,110,385
Ensembl chr 4:57,030,773...57,110,385

G

interleukin 13 receptor subunit alpha 2

affects response to substance

IL13RA2 protein affects the susceptibility to Mitoxantrone

NCBI chr X:115,003,982...115,017,616
Ensembl chr X:115,003,975...115,019,977

G

inner membrane mitochondrial protein

decreases expression

Mitoxantrone results in decreased expression of IMMT protein

NCBI chr 2:86,143,936...86,195,462
Ensembl chr 2:86,143,932...86,195,472

G

IQ motif containing GTPase activating protein 1

affects response to substance

IQGAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:90,388,242...90,502,239
Ensembl chr15:90,388,242...90,502,239

G

interferon regulatory factor 7

affects response to substance

IRF7 protein affects the susceptibility to Mitoxantrone

NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983

G

iroquois homeobox 1

affects response to substance

IRX1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:3,595,832...3,601,403
Ensembl chr 5:3,595,832...3,601,403

G

iroquois homeobox 4

decreases expression

Mitoxantrone results in decreased expression of IRX4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236

G

ISG15 ubiquitin like modifier

affects response to substance

ISG15 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540

G

interferon stimulated exonuclease gene 20

affects response to substance

ISG20 protein affects the susceptibility to Mitoxantrone

NCBI chr15:88,635,632...88,656,483
Ensembl chr15:88,635,670...88,656,483

G

Janus kinase 2

decreases expression

Mitoxantrone results in decreased expression of JAK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

affects response to substance

KCNAB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:5,992,676...6,101,180
Ensembl chr 1:5,990,927...6,101,193

G

potassium voltage-gated channel subfamily H member 2

decreases expression

Mitoxantrone results in decreased expression of KCNH2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

potassium inwardly rectifying channel subfamily J member 2

increases expression

Mitoxantrone results in increased expression of KCNJ2 mRNA

PMID:26537877 PMID:28940058

NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044

G

potassium voltage-gated channel subfamily Q member 1

decreases expression

Mitoxantrone results in decreased expression of KCNQ1 mRNA

PMID:26537877 PMID:28940058

NCBI chr11:2,445,008...2,849,105
Ensembl chr11:2,444,654...2,849,105

G

KRR1 small subunit processome component homolog

affects response to substance

KRR1 protein affects the susceptibility to Mitoxantrone

NCBI chr12:75,490,863...75,511,609
Ensembl chr12:75,490,863...75,511,636

G

KRT10 antisense RNA 1

affects response to substance

KRT10-AS1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr17:40,819,145...40,836,274
Ensembl chr17:40,819,101...40,836,270

G

laminin subunit alpha 2

affects response to substance

LAMA2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566

G

laminin subunit beta 1

affects response to substance

LAMB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:107,923,799...108,003,161
Ensembl chr 7:107,923,799...108,003,213

G

laminin subunit gamma 1

affects response to substance

LAMC1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:183,023,420...183,145,592
Ensembl chr 1:183,023,420...183,145,592

G

LBH regulator of WNT signaling pathway

affects response to substance

LBH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:30,231,534...30,260,028
Ensembl chr 2:30,231,534...30,323,730

G

LIM domain binding 3

decreases expression

Mitoxantrone results in decreased expression of LDB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr10:86,666,788...86,736,072
Ensembl chr10:86,666,785...86,736,072

G

LEM domain nuclear envelope protein 2

affects response to substance

LEMD2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:33,771,213...33,789,130
Ensembl chr 6:33,771,202...33,789,130

G

leucine rich repeat containing G protein-coupled receptor 4

affects response to substance

LGR4 protein affects the susceptibility to Mitoxantrone

NCBI chr11:27,365,961...27,472,790
Ensembl chr11:27,365,961...27,472,790

G

lipase A, lysosomal acid type

affects response to substance

LIPA protein affects the susceptibility to Mitoxantrone

NCBI chr10:89,213,572...89,251,775
Ensembl chr10:89,213,569...89,414,557

G

lipase G, endothelial type

affects response to substance

LIPG protein affects the susceptibility to Mitoxantrone

NCBI chr18:49,561,479...49,599,185
Ensembl chr18:49,560,699...49,599,185

G

LIM and cysteine rich domains 1

increases expression

Mitoxantrone results in increased expression of LMCD1 mRNA

NCBI chr 3:8,501,823...8,574,668
Ensembl chr 3:8,501,807...8,574,668

G

lamin B1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein

NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020

G

mono-ADP ribosylhydrolase 1

affects response to substance

MACROD1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:63,998,558...64,166,113
Ensembl chr11:63,998,558...64,166,113

G

MAF bZIP transcription factor F

affects response to substance

MAFF mRNA affects the susceptibility to Mitoxantrone

NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507

G

MAGE family member A6

affects response to substance

MAGEA6 protein affects the susceptibility to Mitoxantrone

NCBI chr X:152,766,136...152,769,689
Ensembl chr X:152,766,136...152,769,716

G

MAGE family member D1

affects response to substance

MAGED1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:51,803,076...51,902,354
Ensembl chr X:51,803,007...51,902,354

G

MAGE family member D4B

affects response to substance

MAGED4B protein affects the susceptibility to Mitoxantrone

NCBI chr X:52,061,827...52,069,272
Ensembl chr X:52,061,827...52,069,219

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

Mitoxantrone results in decreased expression of and results in increased lipidation of MAP1LC3B protein

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

malate dehydrogenase 2

decreases expression

Mitoxantrone results in decreased expression of MDH2 protein

NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508

G

MDM2 proto-oncogene

decreases response to substance

MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

mesoderm specific transcript

affects response to substance

MEST protein affects the susceptibility to Mitoxantrone

NCBI chr 7:130,486,175...130,506,465
Ensembl chr 7:130,486,171...130,506,465

G

microRNA 654

increases response to substance

MIR654 mRNA results in increased susceptibility to Mitoxantrone

NCBI chr14:101,040,219...101,040,299
Ensembl chr14:101,040,219...101,040,299

G

microRNA 765

increases response to substance

MIR765 mRNA results in increased susceptibility to Mitoxantrone

NCBI chr 1:156,936,131...156,936,244
Ensembl chr 1:156,936,131...156,936,244

G

molybdenum cofactor sulfurase

affects response to substance

MOCOS protein affects the susceptibility to Mitoxantrone

NCBI chr18:36,187,497...36,272,157
Ensembl chr18:36,187,497...36,272,157

G

mitochondrial pyruvate carrier 2

affects response to substance

MPC2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:167,916,675...167,937,072
Ensembl chr 1:167,916,675...167,937,072

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

affects response to substance

MTHFD2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565

G

MAX interactor 1, dimerization protein

affects response to substance

MXI1 protein affects the susceptibility to Mitoxantrone

NCBI chr10:110,207,605...110,287,365
Ensembl chr10:110,207,605...110,287,365

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
multiple interactions

Mitoxantrone results in decreased expression of MYC mRNA
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

MYC binding protein 2

affects response to substance

MYCBP2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:77,044,657...77,327,094
Ensembl chr13:77,042,474...77,327,094

G

myosin heavy chain 6

decreases expression

Mitoxantrone results in decreased expression of MYH6 mRNA

PMID:26537877 PMID:28940058

NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273

G

myosin heavy chain 7

decreases expression

Mitoxantrone results in decreased expression of MYH7 mRNA

PMID:26537877 PMID:28940058

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

G

myomesin 2

decreases expression

Mitoxantrone results in decreased expression of MYOM2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:2,045,046...2,145,456
Ensembl chr 8:2,045,046...2,165,552

G

nicotinamide phosphoribosyltransferase

affects response to substance

NAMPT protein affects the susceptibility to Mitoxantrone

NCBI chr 7:106,248,298...106,285,888
Ensembl chr 7:106,248,298...106,285,966

G

NADH:ubiquinone oxidoreductase subunit S5

affects response to substance

NDUFS5 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:39,026,350...39,034,615
Ensembl chr 1:39,026,318...39,034,636

G

neurofilament heavy chain

affects response to substance

NEFH protein affects the susceptibility to Mitoxantrone

NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390

G

nidogen 2

affects response to substance

NID2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:52,004,809...52,069,059
Ensembl chr14:52,004,809...52,069,059

G

nuclear receptor subfamily 3 group C member 1

decreases activity

Mitoxantrone results in decreased activity of NR3C1 protein

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

nuclear receptor subfamily 4 group A member 2

affects response to substance

NR4A2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348

G

nebulin related anchoring protein

decreases expression

Mitoxantrone results in decreased expression of NRAP mRNA

PMID:26537877 PMID:28940058

NCBI chr10:113,588,714...113,664,041
Ensembl chr10:113,588,714...113,664,070

G

nuclear receptor interacting protein 1

affects response to substance

NRIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr21:14,961,235...15,065,936
Ensembl chr21:14,961,235...15,065,936

G

3-oxoacid CoA-transferase 1

affects response to substance

OXCT1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:41,730,065...41,870,425
Ensembl chr 5:41,730,065...41,870,425

G

prolyl 4-hydroxylase subunit alpha 1

affects response to substance

P4HA1 protein affects the susceptibility to Mitoxantrone

NCBI chr10:73,007,217...73,096,866
Ensembl chr10:73,007,217...73,096,974

G

parkin coregulated like

affects response to substance

PACRGL mRNA affects the susceptibility to Mitoxantrone

NCBI chr 4:20,696,282...20,767,373
Ensembl chr 4:20,696,282...20,752,907

G

poly(ADP-ribose) polymerase 1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

PMID:8840993 PMID:15582267

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

PBX homeobox 1

affects response to substance

PBX1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:164,559,184...164,886,047
Ensembl chr 1:164,555,584...164,899,296

G

phosphodiesterase 4D

affects response to substance

PDE4D protein affects the susceptibility to Mitoxantrone

NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120

G

phosphodiesterase 8A

affects response to substance

PDE8A protein affects the susceptibility to Mitoxantrone

NCBI chr15:84,980,467...85,139,142
Ensembl chr15:84,980,440...85,139,145

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression

Mitoxantrone results in decreased expression of PDHA1 protein

NCBI chr X:19,343,927...19,361,718
Ensembl chr X:19,343,893...19,361,718

G

prohibitin 2

decreases expression

Mitoxantrone results in decreased expression of PHB2 protein

NCBI chr12:6,965,327...6,970,753
Ensembl chr12:6,965,327...6,970,780

G

phosphoglycerate dehydrogenase

affects response to substance

PHGDH protein affects the susceptibility to Mitoxantrone

NCBI chr 1:119,711,934...119,744,215
Ensembl chr 1:119,648,411...119,744,218

G

PLAG1 like zinc finger 1

affects response to substance

PLAGL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:143,940,300...144,064,599
Ensembl chr 6:143,940,300...144,064,599

G

plasminogen activator, tissue type

affects response to substance

PLAT protein affects the susceptibility to Mitoxantrone

NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709

G

phospholipase C beta 4

affects response to substance

PLCB4 protein affects the susceptibility to Mitoxantrone

NCBI chr20:9,068,678...9,480,808
Ensembl chr20:9,067,825...9,504,593

G

pyridoxal phosphate binding protein

affects response to substance

PLPBP protein affects the susceptibility to Mitoxantrone

NCBI chr 8:37,762,546...37,779,768
Ensembl chr 8:37,762,595...37,779,768

G

PML nuclear body scaffold

affects mutagenesis

Mitoxantrone affects the mutagenesis of PML gene

NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827

G

POM121 and ZP3 fusion

affects response to substance

POMZP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:76,609,986...76,627,279
Ensembl chr 7:76,609,986...76,627,279

G

protein phosphatase 1 regulatory inhibitor subunit 2

affects response to substance

PPP1R2 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:195,514,428...195,543,325
Ensembl chr 3:195,514,428...195,543,386

G

protein phosphatase 1 regulatory subunit 3A

decreases expression

Mitoxantrone results in decreased expression of PPP1R3A mRNA

PMID:26537877 PMID:28940058

NCBI chr 7:113,876,777...113,919,009
Ensembl chr 7:113,876,777...114,075,920

G

PR/SET domain 16

decreases expression

Mitoxantrone results in decreased expression of PRDM16 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:3,069,203...3,438,621
Ensembl chr 1:3,069,168...3,438,621

G

peroxiredoxin 2

affects response to substance

PRDX2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800

G

PRELI domain containing 3B

affects response to substance

PRELID3B protein affects the susceptibility to Mitoxantrone

NCBI chr20:59,033,145...59,042,786
Ensembl chr20:59,033,145...59,042,809

G

protein kinase cAMP-dependent X-linked catalytic subunit

increases expression

Mitoxantrone results in increased expression of PRKX mRNA

PMID:26537877 PMID:28940058

NCBI chr X:3,604,340...3,713,649
Ensembl chr X:3,604,340...3,713,649

G

protein tyrosine phosphatase receptor type E

affects response to substance

PTPRE protein affects the susceptibility to Mitoxantrone

NCBI chr10:127,907,103...128,085,855
Ensembl chr10:127,907,103...128,085,855

G

glycogen phosphorylase, muscle associated

decreases expression

Mitoxantrone results in decreased expression of PYGM mRNA

PMID:26537877 PMID:28940058

NCBI chr11:64,746,389...64,760,715
Ensembl chr11:64,746,389...64,759,974

G

retinoic acid receptor alpha

affects mutagenesis

Mitoxantrone affects the mutagenesis of RARA gene

NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643

G

retinoic acid receptor beta

increases expression

Mitoxantrone results in increased expression of RARB mRNA alternative form

NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932

G

RAS p21 protein activator 1

affects response to substance

RASA1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:87,267,883...87,391,916
Ensembl chr 5:87,267,883...87,391,931

G

RB binding protein 8, endonuclease

affects response to substance

RBBP8 protein affects the susceptibility to Mitoxantrone

NCBI chr18:22,914,139...23,026,486
Ensembl chr18:22,798,261...23,026,488

G

RNA binding motif protein 17

multiple interactions
decreases response to substance

LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr10:6,089,034...6,117,447
Ensembl chr10:6,089,034...6,117,457

G

RCC1 and BTB domain containing protein 1

affects response to substance

RCBTB1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:49,531,946...49,585,558
Ensembl chr13:49,531,946...49,585,558

G

ring finger and CHY zinc finger domain containing 1

affects response to substance

RCHY1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:75,479,033...75,514,715
Ensembl chr 4:75,479,033...75,514,764

G

regulator of G protein signaling 2

affects response to substance

RGS2 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275

G

Rho family GTPase 1

increases expression

Mitoxantrone results in increased expression of RND1 mRNA

NCBI chr12:48,857,145...48,865,870
Ensembl chr12:48,857,145...48,865,870

G

Ras related GTP binding D

affects response to substance

RRAGD mRNA affects the susceptibility to Mitoxantrone

NCBI chr 6:89,364,616...89,412,273
Ensembl chr 6:89,364,616...89,412,273

G

RUNX family transcription factor 3

affects response to substance

RUNX3 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:24,899,511...24,965,138
Ensembl chr 1:24,899,511...24,965,121

G

ryanodine receptor 2

decreases expression

Mitoxantrone results in decreased expression of RYR2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988

G

S100 calcium binding protein P

affects response to substance

S100P protein affects the susceptibility to Mitoxantrone

NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170

G

spalt like transcription factor 2

affects response to substance

SALL2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:21,521,080...21,537,121
Ensembl chr14:21,521,080...21,537,216

G

SATB homeobox 2

affects response to substance

SATB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:199,269,500...199,471,266
Ensembl chr 2:199,269,505...199,471,266

G

stearoyl-CoA desaturase

affects response to substance

SCD protein affects the susceptibility to Mitoxantrone

NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826

G

schwannomin interacting protein 1

affects response to substance

SCHIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:159,273,244...159,897,359
Ensembl chr 3:159,839,861...159,897,360
Ensembl chr 3:159,839,861...159,897,360

G

sodium voltage-gated channel beta subunit 2

decreases expression

Mitoxantrone results in decreased expression of SCN2B mRNA

PMID:26537877 PMID:28940058

NCBI chr11:118,162,806...118,176,639
Ensembl chr11:118,162,806...118,176,639

G

sodium voltage-gated channel alpha subunit 5

decreases expression

Mitoxantrone results in decreased expression of SCN5A mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,687

G

syndecan 2

affects response to substance

SDC2 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:96,493,813...96,611,790
Ensembl chr 8:96,493,813...96,611,790

G

SEC31 homolog A, COPII coat complex component

affects response to substance

SEC31A protein affects the susceptibility to Mitoxantrone

NCBI chr 4:82,818,509...82,900,569
Ensembl chr 4:82,818,509...82,901,166

G

serpin family E member 1

increases expression

Mitoxantrone results in increased expression of SERPINE1 mRNA

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

stratifin

affects response to substance

SFN protein affects the susceptibility to Mitoxantrone

NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456

G

secreted frizzled related protein 4

affects response to substance

SFRP4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:37,905,932...37,916,817
Ensembl chr 7:37,905,932...38,025,695

G

solute carrier family 16 member 6

affects response to substance

SLC16A6 protein affects the susceptibility to Mitoxantrone

NCBI chr17:68,267,026...68,291,479
Ensembl chr17:68,267,026...68,291,267

G

solute carrier family 25 member 11

decreases expression

Mitoxantrone results in decreased expression of SLC25A11 protein

NCBI chr17:4,937,130...4,940,046
Ensembl chr17:4,937,130...4,940,053

G

solute carrier family 7 member 5

affects response to substance

SLC7A5 protein affects the susceptibility to Mitoxantrone

NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507

G

solute carrier organic anion transporter family member 4A1

affects response to substance

SLCO4A1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:62,642,503...62,690,740
Ensembl chr20:62,642,503...62,685,785

G

SMAD family member 2

affects response to substance

SMAD2 protein affects the susceptibility to Mitoxantrone

NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146

G

sorbin and SH3 domain containing 1

affects response to substance

SORBS1 protein affects the susceptibility to Mitoxantrone

NCBI chr10:95,311,773...95,561,371
Ensembl chr10:95,311,771...95,561,414

G

spondin 1

affects response to substance

SPON1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:13,962,723...14,268,133
Ensembl chr11:13,962,723...14,268,133

G

spondin 2

affects response to substance

SPON2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:1,166,932...1,208,844
Ensembl chr 4:1,166,932...1,208,962

G

secreted phosphoprotein 1

increases expression

Mitoxantrone results in increased expression of SPP1 mRNA

NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532

G

sequestosome 1

decreases expression
affects expression

Mitoxantrone metabolite results in decreased expression of SQSTM1 protein
Mitoxantrone affects the expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

steroid 5 alpha-reductase 1

affects response to substance

SRD5A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:6,633,440...6,674,386
Ensembl chr 5:6,633,290...6,676,539

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

Mitoxantrone results in decreased expression of SUCLA2 protein

NCBI chr13:47,942,656...48,001,273
Ensembl chr13:47,745,736...48,037,968

G

synaptotagmin like 2

affects response to substance

SYTL2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr11:85,694,229...85,854,870
Ensembl chr11:85,694,224...85,811,159

G

transgelin

affects response to substance

TAGLN protein affects the susceptibility to Mitoxantrone

NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464

G

transporter 1, ATP binding cassette subfamily B member

affects response to substance

TAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816

G

TBC1 domain family member 8

affects response to substance

TBC1D8 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:101,007,228...101,151,382
Ensembl chr 2:101,007,228...101,252,866

G

trefoil factor 3

affects response to substance

TFF3 protein affects the susceptibility to Mitoxantrone

NCBI chr21:42,311,667...42,315,409
Ensembl chr21:42,311,667...42,315,409

G

transforming growth factor beta 2

increases expression

Mitoxantrone results in increased expression of TGFB2 mRNA

NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619

G

TIA1 cytotoxic granule associated RNA binding protein

affects response to substance

TIA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:70,209,444...70,248,793
Ensembl chr 2:70,209,444...70,248,660

G

TIMP metallopeptidase inhibitor 1

increases expression

Mitoxantrone results in increased expression of TIMP1 mRNA

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

transmembrane protein 47

affects response to substance

TMEM47 protein affects the susceptibility to Mitoxantrone

NCBI chr X:34,627,075...34,657,285
Ensembl chr X:34,627,075...34,657,285

G

tankyrase

affects response to substance

TNKS protein affects the susceptibility to Mitoxantrone

NCBI chr 8:9,555,912...9,782,346
Ensembl chr 8:9,555,912...9,782,346

G

troponin T1, slow skeletal type

decreases expression

Mitoxantrone results in decreased expression of TNNT1 mRNA

PMID:26537877 PMID:28940058

NCBI chr19:55,132,698...55,149,206
Ensembl chr19:55,132,698...55,149,206

G

tumor protein p53

affects activity

Mitoxantrone affects the activity of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

G

tumor protein D52

affects response to substance

TPD52 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:80,031,082...80,171,564
Ensembl chr 8:80,034,745...80,231,232

G

tropomyosin 1

affects response to substance

TPM1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:63,042,747...63,071,915
Ensembl chr15:63,042,620...63,071,915

G

tribbles pseudokinase 1

affects response to substance

TRIB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:125,430,358...125,438,403
Ensembl chr 8:125,430,358...125,438,403

G

tripartite motif containing 2

affects response to substance

TRIM2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:153,152,163...153,339,317
Ensembl chr 4:153,152,163...153,339,319

G

ubiquitin like 3

affects response to substance

UBL3 protein affects the susceptibility to Mitoxantrone

NCBI chr13:29,764,371...29,850,617
Ensembl chr13:29,764,371...29,850,617

G

ubiquitin C-terminal hydrolase L1

affects response to substance

UCHL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455

G

ubiquinol-cytochrome c reductase hinge protein

affects response to substance

UQCRH protein affects the susceptibility to Mitoxantrone

NCBI chr 1:46,303,698...46,316,776
Ensembl chr 1:46,303,698...46,316,776

G

utrophin

affects response to substance

UTRN protein affects the susceptibility to Mitoxantrone

NCBI chr 6:144,285,335...144,853,034
Ensembl chr 6:144,285,335...144,853,034

G

versican

affects response to substance

VCAN protein affects the susceptibility to Mitoxantrone

NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303

G

voltage dependent anion channel 1

decreases expression

Mitoxantrone results in decreased expression of VDAC1 protein

NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975

G

tryptophanyl-tRNA synthetase 1

affects response to substance

WARS1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805

G

WASH complex subunit 3

affects response to substance

WASHC3 protein affects the susceptibility to Mitoxantrone

NCBI chr12:102,012,840...102,062,124
Ensembl chr12:102,012,840...102,062,149

G

X-linked inhibitor of apoptosis

affects localization
decreases expression

Mitoxantrone affects the localization of XIAP protein
Mitoxantrone results in decreased expression of XIAP protein

NCBI chr X:123,859,708...123,913,972
Ensembl chr X:123,859,712...123,913,972

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

increases expression

Mitoxantrone results in increased expression of YWHAE protein

NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222

G

zinc finger AN1-type containing 1

affects response to substance

ZFAND1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:81,701,331...81,721,304
Ensembl chr 8:81,701,334...81,732,903

G

zinc finger matrin-type 3

increases expression

Mitoxantrone results in increased expression of ZMAT3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 3:179,017,223...179,072,513
Ensembl chr 3:178,960,121...179,072,215

G

zinc finger and SCAN domain containing 18

affects response to substance

ZSCAN18 protein affects the susceptibility to Mitoxantrone

NCBI chr19:58,083,842...58,118,426
Ensembl chr19:58,083,838...58,118,427

Obtusifolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 6

decreases activity

obtusifolin results in decreased activity of SLC22A6 protein

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

decreases activity

obtusifolin results in decreased activity of SLC22A8 protein

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

physcion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases expression

physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily B member 4

decreases expression

physcione results in decreased expression of ABCB4 mRNA

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 2

decreases expression

physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

decreases expression

physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression

physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

physcione results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 21 subfamily A member 2

increases hydroxylation

CYP21A2 protein results in increased hydroxylation of physcione

NCBI chr 6:32,038,415...32,041,644
Ensembl chr 6:32,038,327...32,041,644

G

cytochrome P450 family 27 subfamily A member 1

decreases expression

physcione results in decreased expression of CYP27A1 mRNA

NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293

G

cytochrome P450 family 2 subfamily B member 6

increases hydroxylation

CYP2B6 protein results in increased hydroxylation of physcione

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily C member 19

increases hydroxylation

CYP2C19 protein results in increased hydroxylation of physcione

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 3 subfamily A member 4

increases hydroxylation

CYP3A4 protein results in increased hydroxylation of physcione

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein

NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898

G

solute carrier family 10 member 1

decreases expression

physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

sulfotransferase family 1A member 1

decreases activity

physcione results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of physcione

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

quinizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

1,4-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

albumin

affects binding

1,4-dihydroxyanthraquinone binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

1,4-dihydroxyanthraquinone results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

estrogen receptor 1

multiple interactions

1,4-dihydroxyanthraquinone binds to and results in increased activity of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 1 member A10

increases glucuronidation

UGT1A10 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300

G

UDP glucuronosyltransferase family 1 member A7

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300

Reactive blue 2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase mu 2

decreases activity

Cibacron Blue F 3GA results in decreased activity of GSTM2 protein

NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551

G

purinergic receptor P2X 1

affects binding

Reactive blue 2 binds to P2rx1 protein

RGD

NCBI chr17:3,896,592...3,916,465
Ensembl chr17:3,896,592...3,916,476

G

purinergic receptor P2X 5

affects transport

Reactive blue 2 affects transport ion flux of P2rx5 receptor

RGD

NCBI chr17:3,673,227...3,696,155
Ensembl chr17:3,672,199...3,696,240

G

poly(ADP-ribose) polymerase 1

multiple interactions

Cibacron Blue F 3GA inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

tumor protein p53

increases degradation

Cibacron Blue F 3GA results in increased degradation of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538

Rhein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

actin alpha 2, smooth muscle

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339

G

adhesion G protein-coupled receptor E1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr19:6,887,579...6,940,450
Ensembl chr19:6,887,566...6,940,459

G

aryl hydrocarbon receptor

multiple interactions

rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152

G

alkB homolog 2, alpha-ketoglutarate dependent dioxygenase

decreases activity

rhein results in decreased activity of ALKBH2 protein

NCBI chr12:109,088,189...109,093,472
Ensembl chr12:109,088,188...109,093,631

G

BCL2 associated X, apoptosis regulator

increases expression

rhein results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

beclin 1

decreases expression

rhein results in decreased expression of BECN1 protein

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

caspase 1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

decreases expression

rhein results in decreased expression of CASP3 protein

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases cleavage

rhein results in increased cleavage of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

decreases expression

rhein results in decreased expression of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cytochrome P450 family 1 subfamily A member 1

decreases activity

rhein results in decreased activity of CYP1A1 protein

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

rhein results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

rhein results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

rhein results in decreased activity of CYP2C9 protein

PMID:27633141 PMID:33438235

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily D member 6

decreases activity

rhein results in decreased activity of CYP2D6 protein

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

epidermal growth factor

decreases expression

rhein results in decreased expression of EGF protein

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

erb-b2 receptor tyrosine kinase 2

decreases expression

rhein results in decreased expression of ERBB2 protein

NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426

G

glutamic--pyruvic transaminase

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

rhein results in decreased expression of HIF1A protein
rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

interferon gamma

increases expression
multiple interactions

rhein results in increased expression of IFNG protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 10

multiple interactions

rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 17A

increases expression

rhein results in increased expression of IL17A protein

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 18

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096

G

interleukin 1 beta

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

increases expression

rhein results in increased expression of IL2 protein

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 6

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:26784856 PMID:37023836

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

nuclear factor kappa B subunit 1

affects localization
multiple interactions
decreases activity

rhein affects the localization of NFKB1 protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]
rhein results in decreased activity of NFKB1 protein

PMID:21457705 PMID:37023836

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NLR family pyrin domain containing 3

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108

G

prostaglandin-endoperoxide synthase 2

decreases expression

rhein results in decreased expression of PTGS2 protein

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RELA proto-oncogene, NF-kB subunit

decreases activity
multiple interactions
affects localization

rhein results in decreased activity of RELA protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]
cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]

PMID:21457705 PMID:37023836

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

solute carrier family 22 member 6

multiple interactions

rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967

G

solute carrier family 22 member 8

multiple interactions

rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]

NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841

G

sequestosome 1

increases expression

rhein results in increased expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

sulfotransferase family 1A member 1

decreases activity

rhein results in decreased activity of SULT1A1 protein

NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044

G

transforming growth factor beta 1

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

increases expression
multiple interactions

rhein results in increased expression of TNF protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:26784856 PMID:31436023 PMID:37023836

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNFRSF1A associated via death domain

increases expression

rhein results in increased expression of TRADD protein

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

G

TNF receptor associated factor 1

increases expression

rhein results in increased expression of TRAF1 protein

NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173

G

vascular endothelial growth factor A

decreases expression
decreases response to substance

rhein results in decreased expression of VEGFA protein
rhein results in decreased susceptibility to VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

rubiadin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 2

decreases expression

rubiadin results in decreased expression of CA2 mRNA

NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493

G

calcitonin receptor

decreases expression

rubiadin results in decreased expression of CALCR mRNA

NCBI chr 7:93,424,486...93,574,724
Ensembl chr 7:93,424,486...93,574,730

G

cathepsin K

increases activity

rubiadin results in increased activity of CTSK protein

NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577

G

cytochrome P450 family 1 subfamily A member 2

decreases activity

rubiadin results in decreased activity of CYP1A2 protein

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

rubiadin results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 2 subfamily C member 9

decreases activity

rubiadin results in decreased activity of CYP2C9 protein

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily D member 6

decreases activity

rubiadin results in decreased activity of CYP2D6 protein

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

NFKB inhibitor alpha

multiple interactions

rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

TNF receptor superfamily member 11b

increases expression

rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF superfamily member 11

decreases expression
multiple interactions

rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26034
chemical entity	26024
molecular entity	25991
polyatomic entity	25876
molecule	25277
cyclic compound	24275
homocyclic compound	22040
carbocyclic compound	22040
carbopolycyclic compound	19842
carbotricyclic compound	1507
anthracenes	601
anthraquinone	533
(+)-3,3′,7,7′,8,8′-hexahydroxy-5,5′-dimethylbianthraquinone (2240A)	0
(1'R)-1,8-dihydroxy-2-(1-hydroxyethyl)-3-methylanthraquinone	0
(1,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetic acid	0
(1R,18R,19R,31S)-7,19,23,25-tetrahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.01,17.03,16.04,13.06,11.017,22.024,29]hentriaconta-3(16),4(13),6(11),7,9,14,22,24(29),25,27-decaene-5,12,21-trione	0
(1R,18R,31S)-7,23,25-trihydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.01,17.03,16.04,13.06,11.017,22.024,29]hentriaconta-3(16),4(13),6(11),7,9,14,19,22,24(29),25,27-undecaene-5,12,21-trione	0
(1R,18S,19R,31S)-7,18,19,23,25-pentahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.01,17.03,16.04,13.06,11.017,22.024,29]hentriaconta-3(16),4(13),6(11),7,9,14,22,24(29),25,27-decaene-5,12,21-trione	0
(1S,2R,11R,14R,16S,17S)-2,8,11,16,17-pentahydroxy-16-methyl-19-oxapentacyclo[12.4.1.01,14.02,11.04,9]nonadeca-4(9),5,7,12-tetraene-3,10,18-trione	0
(3R)-3-hydroxy-3-methyl-4-(1,4,5-trihydroxy-9,10-dioxoanthracen-2-yl)butanamide	0
(3R)-4-(1,4-dihydroxy-5-methoxy-9,10-dioxoanthracen-2-yl)-3-hydroxy-3-methylbutanamide	0
(Betar)-6-(2,6-Dideoxy-beta-D-glucopyranosyl)-9,10-dihydro-beta,1,5-trihydroxy-beta-methyl-9,10-dioxoanthracene-2-butanoic acid	0
1,3-Dimethoxyanthraquinone	0
1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione	0
1,4-dihydroxy-2,5-dimethoxy-9,10-anthraquinone	0
1,5-Dihydroxy-2-methoxy-6-methylanthraquinone	0
1,5-Dihydroxy-4,8-bis(hydroxy(hydroxymethyl)amino)anthraquinone	0
1,5-dihydroxy-3,4-dimethoxy-2-methylanthraquinone	0
1,8-Dihydroxy-3-hydroxymethylanthraquinone 8-O-b-D-glucoside	0
1,8-dihydroxy-2-(1-hydroxyethyl)-6-methoxy-3-methylanthraquinone	0
1-Amino-2,4-dibromoanthraquinone	4
1-Amino-2-methylanthraquinone	0
1-Hydroxy-2-[(1Z)-4-methyl-1,3-pentadien-1-yl]-9,10-anthraquinone	0
1-O-beta-D-Glucopyranosylaloeemodin	0
1-O-methyl-6-O-(alpha-D-ribofuranosyl)emodin	0
1-amino-4-(1-naphthalenylamino)-9,10-dioxo-2-anthracenesulfonic acid	0
1-amino-4-(4-chloroanilino)-9,10-dioxo-2-anthracenesulfonic acid	0
1-hydroxy-2,6,8-trimethoxy-9,10-anthraquinone	0
10-deoxybostrycin	0
100-2	0
11-Deoxylandomycinone	0
11-hydroxy-5-methyl-2-(2-methyl-3-prop-1-enyloxiran-2-yl)naphtho[2,3-h]chromene-4,7,12-trione	0
14-dehydrorubellin D	0
2,2'-bis-(7-methyl-1,4,5-trihydroxy-anthracene-9,10-dione)	0
2,3,4a,8-Tetrahydroxy-12b-(5-hydroxy-6-methyloxan-2-yl)oxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione	0
2,3,6,7-Tetrakis(allyloxy)-9,10-anthraquinone	0
2-(1-benzimidazolyl)acetic acid [2-[(9,10-dioxo-1-anthracenyl)amino]-2-oxoethyl] ester	0
2-(4-Methyl-1,3-pentadienyl)anthraquinone	0
2-(4-Methyl-3-pentenyl)anthraquinone	0
2-(dimethoxymethyl)-1-hydroxyanthracene-9,10-dione	0
2-(hydroxymethyl)anthraquinone	0
2-Aminoanthraquinone	1
2-Methyl-1-nitroanthraquinone	0
2-[[5-(2-carboxyanilino)-9,10-dioxo-1-anthracenyl]amino]benzoic acid	0
2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]thio]-N-(9,10-dioxo-2-anthracenyl)acetamide	0
2-acetyl-1,8-dihydroxy-3-methylanthraquinone	0
2-carbomethoxy-9,10-anthraquinone	0
2-cyclopentylacetic acid [2-[(3-chloro-9,10-dioxo-2-anthracenyl)amino]-2-oxoethyl] ester	0
2-ethyl-1,8-dihydroxy-3-methyl-anthraquinone	0
2-ethyl-1-hydroxy-8-methoxy-3-methylanthracene-9,10-dione	0
2-methylanthraquinone +	15
3-O-(alpha-D-ribofuranosyl)questinol	0
3-O-Methylalaternin-7-O-sulphate	0
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-1,8-dihydroxy-6-methylanthracene-9,10-dione	0
3-methyl xanthopurpurin 6-O-methyl ether 8-O-beta-D-gentiobioside	0
4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid	0
4,5-dihydroxy-1-methyl-anthraquinone	0
4-Aminophyscion	0
4-acetylchrysophanol	0
4-hydroxypleurogrisein	0
5-Chloroparietin	0
6,8-Di-O-methylaverufin	0
6-deoxy-13-hydroxy-8,11-dionedihydrogranaticin B	0
7-(gamma,gamma)-dimethylallyloxymacrosporin	0
8-D-Olivosyl-landomycin	0
8-Hydroxy-1-methoxy-3-methylanthraquinone	0
8-O-beta-D-gentiobioside of xanthorin 1-O-methyl ether	0
9,10-anthraquinone +	26
9,10-dioxo-1-anthracenecarboxylic acid [2-(2,3-dimethylanilino)-2-oxoethyl] ester	0
AH-1763 IIa	0
AQ-284a	0
Alizarin 2-methyl ether	0
Aloe emodin w-acetate	0
Amicenomycin B	0
Amycomycin A	0
Angelmicin B	0
Anhydroflavomannin-9,10-quinone 6,6',8'-tri-O-methyl ether	0
Ankinomycin	0
Aspetritone A	0
Austrocortinin 8-O-beta-D-gentiobioside	0
BDA-366	0
BE-43472B	0
Beta-Indomycinone	0
Blanchaquinone	0
Caeruleoramularin	0
Cassiamin C	0
Cervimycin A	0
Cervimycin B	0
Chattamycin A	0
Chattamycin B	0
Chryso-obtusin glucoside	0
Chrysophanein	0
Chrysophanol 8-(6-galloylglucoside)	0
Chrysophanol 8-gentiobioside	0
Chrysophanol O-3'-acetyl-alpha-D-ribofuranoside	0
Citreorosein-3-O-sulphate	0
Clecarmycin A1	0
Collinone	0
Cytosporanthraxanthone	0
DMI-2	0
Deoxyrubroskyrin	0
Dermocanarin 1	0
Dermocanarin 10	0
Dermocanarin 2	0
Dermocanarin 3	0
Dermocanarin I	0
Dermocanarin II	0
Digiferrugineol	0
Dihydrogranaticin	0
Disperse Blue 1	2
Dothistromin	0
Dynemicin A	0
Dynemicin L	0
Dynemicin M	0
Dynemicin N	0
Dynemicin O	0
Dynemicin P	0
Dynemicin Q	0
Emodin-3-O-sulphate	0
EmycineC	0
Fallacinal	0
Fallacinol	0
Fragilin	0
Frangulin A	4
Frangulin B	4
Fredericamycin E	0
Fridamycin E	0
Fridamycin H	0
Fridamycin I	0
Fusaroskyrin	0
G-Indomycinone	0
Galvaquinone A	0
Galvaquinone B	0
Glucoemodin	0
Glucoobtusifolin	0
Grincamycin B	0
Grincamycin C	0
Grincamycin D	0
Grincamycin K	0
HEDAMYCIN	0
Halawanone C	0
Halawanone D	0
Hibarimicin A	0
Hibarimicin B	0
Hibarimicin C	0
Hibarimicin D	0
Hibarimicin E	0
Hibarimicin G	0
Hibarimicin H	0
Hibarimicin I	0
Hibarimicinone	0
Himalomycin A	0
Himalomycin B	0
Hinakurin	0
Homo-dehydrorabelomycin E	0
Hydramycin	0
Hydroxybostrycin	0
Iridoskyrin	0
Isoviocristin	0
JBIR-116	0
JBIR-85	0
JBIR-91	0
Julichrome Q5.6	0
Julichrome-Q2,3	0
Kerriamycin A	0
Kidamycin	0
LSM-2729	0
Lactonamycin Z	0
Landomycin D	0
Landomycin F	0
Landomycin H	0
Landomycin X	0
Landomycin Z	0
Landomycinone	0
Langkocycline A1	0
Langkocycline A2	0
Langkocycline A3	0
Macrosporin 2-O-(6′-acetyl)-a-D-glucopyranoside	0
Macrosporin-7-O-sulphate	0
Mansoquinone	0
Monacyclinone D	0
Monacyclinone E	0
Monacyclinone F	0
Monodictyquinone A	0
Morakotin B	0
Morindaparvin A	0
N-(4-amino-9,10-dioxo-1-anthracenyl)benzamide	0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]-1-nitro-9,10-dioxo-2-anthracenecarboxamide	0
Nenesophanol	0
Neopluramycin	0
Nigrodiquinone A	0
Nigrosporin A	0
OM-4842	0
Obtusifolin 2-glucoside	0
Ochracenomicin B	0
P371A1	0
Pachybasin	0
Parimycin	0
Phaeosphenone	0
Physcion 8-glucoside	0
Physcionin	0
Protetrone	0
Pyxidicycline A	0
Pyxidicycline B	0
Quinofuracin E	0
Reactive Blue 5	0
Reactive blue 2	5
Rheochrysin	0
Rubellin A	0
Rubellin B	0
Rubellin E	0
Rubellin F	0
Rubiflavinone C-1	0
Rubimycinone A	0
Rubroskyrin	0
Rugulin	0
SF-2330	0
Saliniquinone A	0
Saliniquinone B	0
Saliniquinone C	0
Saliniquinone D	0
Saliniquinone E	0
Saliniquinone F	0
Saptomycin A	0
Saptomycin B	0
Saptomycin D	0
Saptomycin E	0
Saptomycin F	0
Saptomycin G	0
Saptomycin H	0
Sapurimycin	0
Sekgranaticin	0
Shikometabolin C	0
Sterekunthal B	0
Stremycin A	0
Stremycin B	0
Termstrin C	0
Termstrin D	0
Torrubiellin A	0
Urdamycin E	0
Urdamycin F	0
Urdamycin G	0
Urdamycin N6	0
Urdamycin N7	0
Urdamycin N8	0
Urdamycin N9	0
Urdamycin V	0
Uredinorubellin I	0
Uredinorubellin II	0
Ventinone A	0
Vineomycin B2	0
Vineomycin C	0
Vineomycin D	0
Vineomycin E	0
Vineomycin F	0
W-Hydroxyxanthorin 1-O-methyl ester 8-O-	0
Warkmycin CS1	0
Xanthorin	0
Xanthorin 1-O-methyl ether 8-O-beta-D-ge	0
Xanthorin 8-O-beta-D-gentiobioside	0
[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(4,5-dihydroxy-7-methyl-9,10-dioxoanthracen-2-yl)oxyoxolan-2-yl]methyl acetate	0
[(2R,3R,4R,5R)-4-acetyloxy-5-(4,5-dihydroxy-7-methyl-9,10-dioxoanthracen-2-yl)oxy-2-(hydroxymethyl)oxolan-3-yl] acetate	0
anthraquinone-2,6-disulfonic acid	0
delta-Indomycinone	0
ekatetrone	0
glucosyloxyanthraquinone	0
hydroxyanthraquinones +	522
omega-hydroxyxanthorin 1-O-methyl ether	0
w-O-beta-D-Glucopyranosylaloeemodin	0
Path 2
Term	Annotations
CHEBI ontology	26034
subatomic particle	26009
composite particle	26009
hadron	26020
baryon	26009
nucleon	26009
atomic nucleus	26009
atom	26009
main group element atom	25834
p-block element atom	25834
carbon group element atom	25434
carbon atom	25403
organic molecular entity	25392
heteroorganic entity	24766
organochalcogen compound	24378
organooxygen compound	24054
carbonyl compound	23563
ketone	19347
cyclic ketone	16835
quinone	9214
acenoquinone	8212
anthraquinone	533
(+)-3,3′,7,7′,8,8′-hexahydroxy-5,5′-dimethylbianthraquinone (2240A)	0
(1'R)-1,8-dihydroxy-2-(1-hydroxyethyl)-3-methylanthraquinone	0
(1,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetic acid	0
(1R,18R,19R,31S)-7,19,23,25-tetrahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.01,17.03,16.04,13.06,11.017,22.024,29]hentriaconta-3(16),4(13),6(11),7,9,14,22,24(29),25,27-decaene-5,12,21-trione	0
(1R,18R,31S)-7,23,25-trihydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.01,17.03,16.04,13.06,11.017,22.024,29]hentriaconta-3(16),4(13),6(11),7,9,14,19,22,24(29),25,27-undecaene-5,12,21-trione	0
(1R,18S,19R,31S)-7,18,19,23,25-pentahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.01,17.03,16.04,13.06,11.017,22.024,29]hentriaconta-3(16),4(13),6(11),7,9,14,22,24(29),25,27-decaene-5,12,21-trione	0
(1S,2R,11R,14R,16S,17S)-2,8,11,16,17-pentahydroxy-16-methyl-19-oxapentacyclo[12.4.1.01,14.02,11.04,9]nonadeca-4(9),5,7,12-tetraene-3,10,18-trione	0
(3R)-3-hydroxy-3-methyl-4-(1,4,5-trihydroxy-9,10-dioxoanthracen-2-yl)butanamide	0
(3R)-4-(1,4-dihydroxy-5-methoxy-9,10-dioxoanthracen-2-yl)-3-hydroxy-3-methylbutanamide	0
(Betar)-6-(2,6-Dideoxy-beta-D-glucopyranosyl)-9,10-dihydro-beta,1,5-trihydroxy-beta-methyl-9,10-dioxoanthracene-2-butanoic acid	0
1,3-Dimethoxyanthraquinone	0
1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione	0
1,4-dihydroxy-2,5-dimethoxy-9,10-anthraquinone	0
1,5-Dihydroxy-2-methoxy-6-methylanthraquinone	0
1,5-Dihydroxy-4,8-bis(hydroxy(hydroxymethyl)amino)anthraquinone	0
1,5-dihydroxy-3,4-dimethoxy-2-methylanthraquinone	0
1,8-Dihydroxy-3-hydroxymethylanthraquinone 8-O-b-D-glucoside	0
1,8-dihydroxy-2-(1-hydroxyethyl)-6-methoxy-3-methylanthraquinone	0
1-Amino-2,4-dibromoanthraquinone	4
1-Amino-2-methylanthraquinone	0
1-Hydroxy-2-[(1Z)-4-methyl-1,3-pentadien-1-yl]-9,10-anthraquinone	0
1-O-beta-D-Glucopyranosylaloeemodin	0
1-O-methyl-6-O-(alpha-D-ribofuranosyl)emodin	0
1-amino-4-(1-naphthalenylamino)-9,10-dioxo-2-anthracenesulfonic acid	0
1-amino-4-(4-chloroanilino)-9,10-dioxo-2-anthracenesulfonic acid	0
1-hydroxy-2,6,8-trimethoxy-9,10-anthraquinone	0
10-deoxybostrycin	0
100-2	0
11-Deoxylandomycinone	0
11-hydroxy-5-methyl-2-(2-methyl-3-prop-1-enyloxiran-2-yl)naphtho[2,3-h]chromene-4,7,12-trione	0
14-dehydrorubellin D	0
2,2'-bis-(7-methyl-1,4,5-trihydroxy-anthracene-9,10-dione)	0
2,3,4a,8-Tetrahydroxy-12b-(5-hydroxy-6-methyloxan-2-yl)oxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione	0
2,3,6,7-Tetrakis(allyloxy)-9,10-anthraquinone	0
2-(1-benzimidazolyl)acetic acid [2-[(9,10-dioxo-1-anthracenyl)amino]-2-oxoethyl] ester	0
2-(4-Methyl-1,3-pentadienyl)anthraquinone	0
2-(4-Methyl-3-pentenyl)anthraquinone	0
2-(dimethoxymethyl)-1-hydroxyanthracene-9,10-dione	0
2-(hydroxymethyl)anthraquinone	0
2-Aminoanthraquinone	1
2-Methyl-1-nitroanthraquinone	0
2-[[5-(2-carboxyanilino)-9,10-dioxo-1-anthracenyl]amino]benzoic acid	0
2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]thio]-N-(9,10-dioxo-2-anthracenyl)acetamide	0
2-acetyl-1,8-dihydroxy-3-methylanthraquinone	0
2-carbomethoxy-9,10-anthraquinone	0
2-cyclopentylacetic acid [2-[(3-chloro-9,10-dioxo-2-anthracenyl)amino]-2-oxoethyl] ester	0
2-ethyl-1,8-dihydroxy-3-methyl-anthraquinone	0
2-ethyl-1-hydroxy-8-methoxy-3-methylanthracene-9,10-dione	0
2-methylanthraquinone +	15
3-O-(alpha-D-ribofuranosyl)questinol	0
3-O-Methylalaternin-7-O-sulphate	0
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-1,8-dihydroxy-6-methylanthracene-9,10-dione	0
3-methyl xanthopurpurin 6-O-methyl ether 8-O-beta-D-gentiobioside	0
4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid	0
4,5-dihydroxy-1-methyl-anthraquinone	0
4-Aminophyscion	0
4-acetylchrysophanol	0
4-hydroxypleurogrisein	0
5-Chloroparietin	0
6,8-Di-O-methylaverufin	0
6-deoxy-13-hydroxy-8,11-dionedihydrogranaticin B	0
7-(gamma,gamma)-dimethylallyloxymacrosporin	0
8-D-Olivosyl-landomycin	0
8-Hydroxy-1-methoxy-3-methylanthraquinone	0
8-O-beta-D-gentiobioside of xanthorin 1-O-methyl ether	0
9,10-anthraquinone +	26
9,10-dioxo-1-anthracenecarboxylic acid [2-(2,3-dimethylanilino)-2-oxoethyl] ester	0
AH-1763 IIa	0
AQ-284a	0
Alizarin 2-methyl ether	0
Aloe emodin w-acetate	0
Amicenomycin B	0
Amycomycin A	0
Angelmicin B	0
Anhydroflavomannin-9,10-quinone 6,6',8'-tri-O-methyl ether	0
Ankinomycin	0
Aspetritone A	0
Austrocortinin 8-O-beta-D-gentiobioside	0
BDA-366	0
BE-43472B	0
Beta-Indomycinone	0
Blanchaquinone	0
Caeruleoramularin	0
Cassiamin C	0
Cervimycin A	0
Cervimycin B	0
Chattamycin A	0
Chattamycin B	0
Chryso-obtusin glucoside	0
Chrysophanein	0
Chrysophanol 8-(6-galloylglucoside)	0
Chrysophanol 8-gentiobioside	0
Chrysophanol O-3'-acetyl-alpha-D-ribofuranoside	0
Citreorosein-3-O-sulphate	0
Clecarmycin A1	0
Collinone	0
Cytosporanthraxanthone	0
DMI-2	0
Deoxyrubroskyrin	0
Dermocanarin 1	0
Dermocanarin 10	0
Dermocanarin 2	0
Dermocanarin 3	0
Dermocanarin I	0
Dermocanarin II	0
Digiferrugineol	0
Dihydrogranaticin	0
Disperse Blue 1	2
Dothistromin	0
Dynemicin A	0
Dynemicin L	0
Dynemicin M	0
Dynemicin N	0
Dynemicin O	0
Dynemicin P	0
Dynemicin Q	0
Emodin-3-O-sulphate	0
EmycineC	0
Fallacinal	0
Fallacinol	0
Fragilin	0
Frangulin A	4
Frangulin B	4
Fredericamycin E	0
Fridamycin E	0
Fridamycin H	0
Fridamycin I	0
Fusaroskyrin	0
G-Indomycinone	0
Galvaquinone A	0
Galvaquinone B	0
Glucoemodin	0
Glucoobtusifolin	0
Grincamycin B	0
Grincamycin C	0
Grincamycin D	0
Grincamycin K	0
HEDAMYCIN	0
Halawanone C	0
Halawanone D	0
Hibarimicin A	0
Hibarimicin B	0
Hibarimicin C	0
Hibarimicin D	0
Hibarimicin E	0
Hibarimicin G	0
Hibarimicin H	0
Hibarimicin I	0
Hibarimicinone	0
Himalomycin A	0
Himalomycin B	0
Hinakurin	0
Homo-dehydrorabelomycin E	0
Hydramycin	0
Hydroxybostrycin	0
Iridoskyrin	0
Isoviocristin	0
JBIR-116	0
JBIR-85	0
JBIR-91	0
Julichrome Q5.6	0
Julichrome-Q2,3	0
Kerriamycin A	0
Kidamycin	0
LSM-2729	0
Lactonamycin Z	0
Landomycin D	0
Landomycin F	0
Landomycin H	0
Landomycin X	0
Landomycin Z	0
Landomycinone	0
Langkocycline A1	0
Langkocycline A2	0
Langkocycline A3	0
Macrosporin 2-O-(6′-acetyl)-a-D-glucopyranoside	0
Macrosporin-7-O-sulphate	0
Mansoquinone	0
Monacyclinone D	0
Monacyclinone E	0
Monacyclinone F	0
Monodictyquinone A	0
Morakotin B	0
Morindaparvin A	0
N-(4-amino-9,10-dioxo-1-anthracenyl)benzamide	0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]-1-nitro-9,10-dioxo-2-anthracenecarboxamide	0
Nenesophanol	0
Neopluramycin	0
Nigrodiquinone A	0
Nigrosporin A	0
OM-4842	0
Obtusifolin 2-glucoside	0
Ochracenomicin B	0
P371A1	0
Pachybasin	0
Parimycin	0
Phaeosphenone	0
Physcion 8-glucoside	0
Physcionin	0
Protetrone	0
Pyxidicycline A	0
Pyxidicycline B	0
Quinofuracin E	0
Reactive Blue 5	0
Reactive blue 2	5
Rheochrysin	0
Rubellin A	0
Rubellin B	0
Rubellin E	0
Rubellin F	0
Rubiflavinone C-1	0
Rubimycinone A	0
Rubroskyrin	0
Rugulin	0
SF-2330	0
Saliniquinone A	0
Saliniquinone B	0
Saliniquinone C	0
Saliniquinone D	0
Saliniquinone E	0
Saliniquinone F	0
Saptomycin A	0
Saptomycin B	0
Saptomycin D	0
Saptomycin E	0
Saptomycin F	0
Saptomycin G	0
Saptomycin H	0
Sapurimycin	0
Sekgranaticin	0
Shikometabolin C	0
Sterekunthal B	0
Stremycin A	0
Stremycin B	0
Termstrin C	0
Termstrin D	0
Torrubiellin A	0
Urdamycin E	0
Urdamycin F	0
Urdamycin G	0
Urdamycin N6	0
Urdamycin N7	0
Urdamycin N8	0
Urdamycin N9	0
Urdamycin V	0
Uredinorubellin I	0
Uredinorubellin II	0
Ventinone A	0
Vineomycin B2	0
Vineomycin C	0
Vineomycin D	0
Vineomycin E	0
Vineomycin F	0
W-Hydroxyxanthorin 1-O-methyl ester 8-O-	0
Warkmycin CS1	0
Xanthorin	0
Xanthorin 1-O-methyl ether 8-O-beta-D-ge	0
Xanthorin 8-O-beta-D-gentiobioside	0
[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(4,5-dihydroxy-7-methyl-9,10-dioxoanthracen-2-yl)oxyoxolan-2-yl]methyl acetate	0
[(2R,3R,4R,5R)-4-acetyloxy-5-(4,5-dihydroxy-7-methyl-9,10-dioxoanthracen-2-yl)oxy-2-(hydroxymethyl)oxolan-3-yl] acetate	0
anthraquinone-2,6-disulfonic acid	0
delta-Indomycinone	0
ekatetrone	0
glucosyloxyanthraquinone	0
hydroxyanthraquinones +	522
omega-hydroxyxanthorin 1-O-methyl ether	0
w-O-beta-D-Glucopyranosylaloeemodin	0

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