Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:androstane-3,17-dione
go back to main search page
Accession:CHEBI:22542 term browser browse the term
Definition:An androstanoid that is androstane substituted by oxo groups at positions 3 and 17.
Synonyms:related_synonym: Formula=C19H28O2;   InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12?,14-,15-,16-,18-,19-/m0/s1;   InChIKey=RAJWOBJTTGJROA-RNQTWYFASA-N;   SMILES=C[C@]12CC[C@H]3[C@@H](CCC4CC(=O)CC[C@]34C)[C@@H]1CCC2=O
 xref_mesh: MESH:C006576
 xref: Wikipedia:Androstanedione


show annotations for term's descendants           Sort by:
androstane-3,17-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression ISO androstane-3,17-dione results in increased expression of ABL1 mRNA CTD PMID:38122923 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases chemical synthesis
multiple interactions
increases metabolic processing		 ISO AKR1D1 protein alternative form results in increased chemical synthesis of androstane-3,17-dione; AKR1D1 protein results in increased chemical synthesis of androstane-3,17-dione
[AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione; [AKR1D1 protein results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione
AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione; AKR1D1 protein results in increased metabolism of androstane-3,17-dione		 CTD PMID:30928400 NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Ar androgen receptor multiple interactions
increases expression		 ISO apalutamide inhibits the reaction [androstane-3,17-dione results in increased expression of AR mRNA] CTD PMID:38122923 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 increases expression ISO androstane-3,17-dione results in increased expression of CDT1 mRNA CTD PMID:38122923 NCBI chr19:67,529,249...67,534,195
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of androstane-3,17-dione CTD PMID:30926317 NCBI chr10:70,195,637...70,205,735
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Elk1 ETS transcription factor ELK1 increases expression
multiple interactions		 ISO androstane-3,17-dione results in increased expression of ELK1 mRNA
apalutamide inhibits the reaction [androstane-3,17-dione results in increased expression of ELK1 mRNA]		 CTD PMID:38122923 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Klf6 KLF transcription factor 6 increases expression ISO androstane-3,17-dione results in increased expression of KLF6 mRNA CTD PMID:38122923 NCBI chr17:69,449,483...69,458,478
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression		 ISO apalutamide inhibits the reaction [androstane-3,17-dione results in increased expression of MKI67 protein] CTD PMID:38122923 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO androstane-3,17-dione results in increased expression of MYC mRNA CTD PMID:38122923 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Sgo2 shugoshin 2 increases expression ISO androstane-3,17-dione results in increased expression of SGO2 mRNA CTD PMID:38122923 NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:59,548,683...59,573,229 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    chemical entity 19907
      atom 19907
        nonmetal atom 19831
          carbon atom 19781
            organic molecular entity 19781
              lipid 18020
                steroid 15164
                  androstanoid 4831
                    androstane-3,17-dione 10
                      5alpha-androstane-3,17-dione 0
                      5beta-androstane-3,17-dione 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbonyl compound 18947
                                    ketone 17281
                                      oxo steroid 10547
                                        17-oxo steroid 274
                                          androstane-3,17-dione 10
                                            5alpha-androstane-3,17-dione 0
                                            5beta-androstane-3,17-dione 0
paths to the root