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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aminoglycan
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Accession:CHEBI:22506 term browser browse the term
Synonyms:related_synonym: aminoglycans


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chitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chit1 chitinase 1 affects binding ISO CHIT1 protein binds to Chitin CTD PMID:16005164 NCBI chr13:45,565,841...45,613,593
Ensembl chr13:45,593,845...45,613,592 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO [Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of IGF1R mRNA CTD PMID:30041514 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Docetaxel binds to Chitin] which results in decreased expression of MMP9 mRNA]; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of MMP9 mRNA]; [Docetaxel binds to Chitin] which results in decreased expression of MMP9 mRNA; [Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of MMP9 mRNA CTD PMID:30041514 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Muc1 mucin 1, cell surface associated affects binding
multiple interactions		 ISO [Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein
[[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Docetaxel binds to Chitin] which results in decreased expression of MMP9 mRNA]; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Docetaxel binds to Chitin] which results in decreased expression of VEGFA mRNA]; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of MMP9 mRNA]; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of STAT3 mRNA]; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of VEGFA mRNA]; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] which results in increased uptake of Docetaxel; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] which results in increased uptake of Protein Synthesis Inhibitors		 CTD PMID:30041514 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of STAT3 mRNA]; [Docetaxel binds to Chitin] which results in decreased expression of STAT3 mRNA; [Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of STAT3 mRNA CTD PMID:30041514 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Docetaxel binds to Chitin] which results in decreased expression of VEGFA mRNA]; [[Aptamers, Nucleotide binds to Chitin] which binds to MUC1 protein] promotes the reaction [[Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of VEGFA mRNA]; [Docetaxel binds to Chitin] which results in decreased expression of VEGFA mRNA; [Protein Synthesis Inhibitors binds to Chitin] which results in decreased expression of VEGFA mRNA CTD PMID:30041514 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
chitosan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA] CTD PMID:28987369 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein] CTD PMID:28732690 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein] CTD PMID:22704994 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Chitosan results in increased expression of ALPL mRNA; Chitosan results in increased expression of ALPL protein CTD PMID:25246786 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA] CTD PMID:28987369 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 [Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in increased expression of BAX protein
Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of BAX protein]		 CTD PMID:18567086 PMID:30928397 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 [Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in decreased expression of BCL2 protein
[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]		 CTD PMID:18567086 PMID:28732690 PMID:30928397 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Chitosan results in increased expression of BGLAP mRNA CTD PMID:25246786 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 Chitosan metabolite inhibits the reaction [Copper results in increased activity of CASP3 protein]
Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]		 CTD PMID:25542178 PMID:30928397 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:30928397 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP [Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; Chitosan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:12679053 PMID:22704994 PMID:27923682 PMID:30928397 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Clec7a C-type lectin domain containing 7A multiple interactions
decreases expression		 ISO Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC7A mRNA]
Chitosan results in decreased expression of CLEC7A mRNA		 CTD PMID:21329777 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity ISO Chitosan analog results in increased activity of CYP3A4 protein CTD PMID:20831879 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Fish Oils promotes the reaction [Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]] CTD PMID:28987369 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA] CTD PMID:28987369 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:28987369 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gcg glucagon increases expression
increases secretion
multiple interactions		 ISO Chitosan results in increased expression of GCG mRNA
Chitosan results in increased secretion of GCG protein
SB 203580 inhibits the reaction [Chitosan results in increased expression of GCG mRNA]; SB 203580 inhibits the reaction [Chitosan results in increased secretion of GCG protein]		 CTD PMID:23611362 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions		 EXP Chitosan analog results in increased expression of GPX1 mRNA
[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]; [Chitosan analog co-treated with Quercetin] results in increased expression of GPX1 mRNA; Chitosan analog inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]		 CTD PMID:27923682 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA] CTD PMID:30928397 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:28987369 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 mRNA; [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 protein
Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]		 CTD PMID:25542178 PMID:30928397 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases secretion		 ISO Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Chitosan results in increased secretion of IL10 protein		 CTD PMID:21329777 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions		 ISO Chitosan results in increased secretion of IL6 protein
Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]		 CTD PMID:21329777 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein] CTD PMID:28732690 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Chitosan inhibits the reaction [Aminolevulinic Acid analog results in increased activity of MMP2 protein] CTD PMID:18806744 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization		 ISO
EXP		 [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased phosphorylation of NFE2L2 protein
Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; SB 203580 inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]
Chitosan analog affects the localization of NFE2L2 protein		 CTD PMID:25542178 PMID:30928397 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA] CTD PMID:30928397 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in increased expression of NR1H3 protein] CTD PMID:28987369 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein] CTD PMID:28987369 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Chitosan results in increased expression of RUNX2 mRNA; Chitosan results in increased expression of RUNX2 protein CTD PMID:25246786 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 EXP [Chitosan analog co-treated with Quercetin] results in increased expression of SOD1 mRNA; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of SOD1 mRNA]
Chitosan analog results in increased expression of SOD1 mRNA		 CTD PMID:27923682 PMID:30928397 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Chitosan results in increased expression of SPP1 mRNA CTD PMID:25246786 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:28987369 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
decreases expression		 ISO Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]
Chitosan results in decreased expression of TLR2 mRNA		 CTD PMID:21329777 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression
multiple interactions		 ISO Chitosan results in decreased expression of TLR4 mRNA
Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA]		 CTD PMID:21329777 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Chitosan results in increased secretion of TNF protein		 CTD PMID:21329777 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein] CTD PMID:22704994 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
chondroitin sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arsb arylsulfatase B decreases abundance ISO ARSB protein results in decreased abundance of Chondroitin Sulfates CTD PMID:29794138 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Chondroitin Sulfates CTD PMID:21436127 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bdnf brain-derived neurotrophic factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF protein CTD PMID:15385557 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G C3 complement C3 increases cleavage ISO Chondroitin Sulfates analog results in increased cleavage of C3 protein CTD PMID:18434646 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C5 complement C5 increases cleavage ISO Chondroitin Sulfates analog results in increased cleavage of C5 protein CTD PMID:18434646 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA] CTD PMID:17879260 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA] CTD PMID:17879260 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cat catalase multiple interactions EXP Chondroitin Sulfates inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:12736501 PMID:15089041 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects binding ISO Chondroitin Sulfates binds to CCL2 protein CTD PMID:16385517 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein]; Chondroitin Sulfates promotes the reaction [CTSB protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide] CTD PMID:25833952 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL3 protein] CTD PMID:25833952 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein] CTD PMID:25833952 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctss cathepsin S multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein] CTD PMID:25833952 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein] CTD PMID:25833952 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein] CTD PMID:25833952 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein] CTD PMID:25833952 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein] CTD PMID:25833952 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein] CTD PMID:25833952 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein] CTD PMID:25833952 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G F12 coagulation factor XII increases activity ISO Chondroitin Sulfates analog results in increased activity of F12 protein CTD PMID:18434646 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Fgf10 fibroblast growth factor 10 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein; Chondroitin Sulfates analog binds to FGF10 protein CTD PMID:12221095 PMID:15385557 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf16 fibroblast growth factor 16 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF16 protein; Chondroitin Sulfates analog binds to FGF16 protein CTD PMID:12221095 PMID:15385557 NCBI chr  X:70,816,658...70,827,270
Ensembl chr  X:70,817,433...70,878,717 		JBrowse link
G Fgf18 fibroblast growth factor 18 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein; Chondroitin Sulfates analog binds to FGF18 protein CTD PMID:12221095 PMID:15385557 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818 		JBrowse link
G Fgf2 fibroblast growth factor 2 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein; Chondroitin Sulfates analog binds to FGF2 protein CTD PMID:12221095 PMID:15385557 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf23 fibroblast growth factor 23 increases activity ISO Chondroitin Sulfates analog results in increased activity of FGF23 protein CTD PMID:16081635 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Gdnf glial cell derived neurotrophic factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein CTD PMID:15385557 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein; Chondroitin Sulfates analog binds to HBEGF protein CTD PMID:12221095 PMID:15385557 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites] CTD PMID:17605605 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates] CTD PMID:25561734 NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363 		JBrowse link
G Klkb1 kallikrein B1 increases activity ISO Chondroitin Sulfates analog results in increased activity of KLKB1 protein CTD PMID:18434646 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Mdk midkine affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein; Chondroitin Sulfates analog binds to MDK protein CTD PMID:12221095 PMID:15385557 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein CTD PMID:20110869 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:14697411 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein] CTD PMID:17879260 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein] CTD PMID:17879260 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein CTD PMID:17605605 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]] CTD PMID:16945567 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]] CTD PMID:16945567 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein CTD PMID:17605605 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein CTD PMID:17605605 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptn pleiotrophin affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein; Chondroitin Sulfates analog binds to PTN protein CTD PMID:12221095 PMID:15385557 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects binding ISO PTPN11 protein binds to Chondroitin Sulfates CTD PMID:29794138 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein] CTD PMID:17879260 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA CTD PMID:17605605 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 [Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of TNF		 CTD PMID:14697411 PMID:20110869 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates] CTD PMID:25561734 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases expression		 ISO [Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B protein
Chondroitin Sulfates results in increased expression of TNFRSF11B protein		 CTD PMID:17996099 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases expression		 ISO [Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Glucosamine results in increased expression of TNFSF11 mRNA]
Chondroitin Sulfates results in decreased expression of TNFSF11 mRNA		 CTD PMID:17996099 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Vegfa vascular endothelial growth factor A affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to VEGFA protein CTD PMID:15385557 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
dermatan sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF protein CTD PMID:15385557 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G F2 coagulation factor II multiple interactions ISO [Dermatan Sulfate co-treated with SERPIND1 protein] results in decreased activity of F2 protein CTD PMID:11805133 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fgf10 fibroblast growth factor 10 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein CTD PMID:15385557 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf16 fibroblast growth factor 16 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF16 protein CTD PMID:15385557 NCBI chr  X:70,816,658...70,827,270
Ensembl chr  X:70,817,433...70,878,717 		JBrowse link
G Fgf18 fibroblast growth factor 18 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein CTD PMID:15385557 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818 		JBrowse link
G Fgf2 fibroblast growth factor 2 affects binding
increases activity		 ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein
Dermatan Sulfate analog results in increased activity of FGF2 protein		 CTD PMID:15385557 PMID:15563459 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf23 fibroblast growth factor 23 increases activity ISO Dermatan Sulfate analog results in increased activity of FGF23 protein CTD PMID:16081635 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fgf7 fibroblast growth factor 7 increases activity ISO Dermatan Sulfate analog results in increased activity of FGF7 protein CTD PMID:15563459 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Gdnf glial cell derived neurotrophic factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein CTD PMID:15385557 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein CTD PMID:15385557 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Mdk midkine affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein CTD PMID:15385557 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression ISO Dermatan Sulfate results in decreased expression of PDGFRA mRNA CTD PMID:16945567 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO Dermatan Sulfate results in decreased expression of PDGFRB mRNA CTD PMID:16945567 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Ptn pleiotrophin affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein CTD PMID:15385557 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Serpind1 serpin family D member 1 multiple interactions ISO [Dermatan Sulfate co-treated with SERPIND1 protein] results in decreased activity of F2 protein CTD PMID:11805133 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519 		JBrowse link
G Vegfa vascular endothelial growth factor A affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to VEGFA protein CTD PMID:15385557 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
heparan sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of [CCL5 protein binds to CCL5 protein]]; Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of CCL5 protein] CTD PMID:21963154 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Fgf1 fibroblast growth factor 1 affects binding ISO FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein CTD PMID:12604602 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf10 fibroblast growth factor 10 affects activity ISO Heparitin Sulfate affects the activity of FGF10 protein CTD PMID:12781692 PMID:12818887 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
affects binding
increases activity		 ISO Heparitin Sulfate binds to and affects the activity of FGF2 protein
Heparitin Sulfate binds to FGF2 protein
Heparitin Sulfate analog results in increased activity of FGF2 protein		 CTD PMID:12460940 PMID:15464572 PMID:15958608 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf4 fibroblast growth factor 4 affects binding ISO Heparitin Sulfate binds to FGF4 protein CTD PMID:15769253 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466 		JBrowse link
G Fgf7 fibroblast growth factor 7 affects binding ISO Heparitin Sulfate binds to FGF7 protein CTD PMID:15769253 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fgf8 fibroblast growth factor 8 affects binding
increases activity		 ISO Heparitin Sulfate binds to FGF8 protein alternative form
Heparitin Sulfate analog results in increased activity of FGF8 protein		 CTD PMID:12460940 PMID:15769253 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects binding
increases activity		 ISO FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein
Heparitin Sulfate analog results in increased activity of FGFR1 protein alternative form		 CTD PMID:12460940 PMID:12604602 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases activity ISO Heparitin Sulfate analog results in decreased activity of FGFR2 protein mutant form CTD PMID:16373332 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases activity ISO Heparitin Sulfate analog results in increased activity of FGFR3 protein alternative form CTD PMID:12460940 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects binding ISO Heparitin Sulfate analog binds to FGFR4 protein CTD PMID:11278860 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase affects degradation ISO GNS affects the degradation of Heparitin Sulfate CTD PMID:3391615 NCBI chr 7:56,889,139...56,923,170
Ensembl chr 7:56,889,232...56,923,151 		JBrowse link
G Gpc1 glypican 1 affects binding
multiple interactions		 ISO GPC1 protein binds to Heparitin Sulfate
GPC1 protein modified form results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]; nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]; Zinc affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]		 CTD PMID:12732622 NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047 		JBrowse link
G Hpse heparanase multiple interactions
decreases abundance
affects abundance		 ISO
EXP		 [Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate; [phosphomannopentaose sulfate results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate
HPSE protein results in decreased abundance of Heparitin Sulfate
HPSE protein affects the abundance of Heparitin Sulfate		 CTD PMID:16899518 PMID:17121850 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein] CTD PMID:19937756 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions ISO Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 multiple interactions ISO Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr15:3,563,358...3,573,801
Ensembl chr15:3,563,358...3,573,801 		JBrowse link
G Prnp prion protein affects binding ISO PRNP protein modified form binds to Heparitin Sulfate metabolite CTD PMID:18717736 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein CTD PMID:23109338 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] CTD PMID:20067761 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
heparin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects activity
multiple interactions		 ISO Heparin affects the activity of ABCC1 protein
Heparin affects the reaction [ABCC1 protein affects the transport of Doxorubicin]		 CTD PMID:17352253 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ackr3 atypical chemokine receptor 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA] CTD PMID:16401727 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Heparin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:16904936 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actr3 actin related protein 3 increases expression EXP Heparin results in increased expression of ACTR3 protein CTD PMID:17488504 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA] CTD PMID:16401727 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Heparin inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:14966081 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Anxa6 annexin A6 increases expression EXP Heparin results in increased expression of ANXA6 protein CTD PMID:17488504 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433 		JBrowse link
G Apcs amyloid P component, serum increases expression ISO Heparin results in increased expression of APCS protein CTD PMID:17162433 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Copper promotes the reaction [Heparin binds to APP protein]; Zinc promotes the reaction [Heparin binds to APP protein] CTD PMID:25835329 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression EXP Heparin results in increased expression of ARHGDIA protein CTD PMID:17488504 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA] CTD PMID:16401727 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Heparin results in increased expression of BAX protein
Heparin inhibits the reaction [arsenite results in increased expression of BAX protein]		 CTD PMID:11787776 PMID:26677073 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO Heparin results in increased expression of BCL2 protein
Heparin inhibits the reaction [arsenite results in decreased expression of BCL2 protein]		 CTD PMID:11787776 PMID:15205081 PMID:15671997 PMID:26677073 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions
decreases expression		 ISO Heparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]
Heparin results in decreased expression of BMP6 mRNA		 CTD PMID:25633564 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A decreases expression ISO Heparin results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G C3 complement C3 decreases expression ISO Heparin results in decreased expression of C3 protein CTD PMID:7948777 PMID:10568115 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C5 complement C5 decreases expression ISO Heparin results in decreased expression of C5 protein CTD PMID:7948777 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Heparin affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450 		JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP Heparin results in increased expression of CAPG protein CTD PMID:17488504 NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Heparin inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions		 ISO
EXP		 Heparin results in decreased activity of CASP3 protein
Heparin promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]		 CTD PMID:16556679 PMID:30377735 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases activity ISO Heparin results in increased activity of CAT protein CTD PMID:12218949 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 affects binding
multiple interactions		 ISO Heparin binds to CCL11 protein
Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein]		 CTD PMID:17384413 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Heparin results in decreased expression of CCL2 protein CTD PMID:11053056 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Heparin results in decreased expression of CD40LG protein CTD PMID:16391376 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Heparin results in increased expression of CDKN1A protein CTD PMID:10926548 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
increases expression		 ISO Heparin analog results in decreased expression of CDKN1B protein
Heparin analog results in increased expression of CDKN1B protein		 CTD PMID:18057711 PMID:20201787 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain affects binding ISO Heparin binds to COL18A1 protein alternative form CTD PMID:15604266 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Crp C-reactive protein increases expression ISO Heparin results in increased expression of CRP protein CTD PMID:16391376 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA] CTD PMID:16401727 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]] CTD PMID:30377735 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions EXP Heparin inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CXCL10 mRNA] CTD PMID:31813902 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Heparin analog results in decreased expression of CXCL12 mRNA; Heparin analog results in decreased expression of CXCL12 protein CTD PMID:20201787 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]] CTD PMID:16401727 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Heparin analog results in decreased expression of CXCR4 mRNA; Heparin analog results in decreased expression of CXCR4 protein CTD PMID:20201787 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 decreases expression EXP Heparin results in decreased expression of DDAH2 protein CTD PMID:17488504 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Des desmin decreases expression EXP Heparin results in decreased expression of DES protein CTD PMID:9111513 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Heparin analog results in decreased expression of E2F1 protein CTD PMID:20201787 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression
decreases secretion		 ISO
EXP		 Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]; Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]
Heparin results in decreased expression of EDN1 mRNA
Heparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
Heparin results in decreased secretion of EDN1 protein		 CTD PMID:1443220 PMID:7509996 PMID:8408661 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egf epidermal growth factor decreases activity ISO Heparin results in decreased activity of EGF protein CTD PMID:12714831 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases phosphorylation		 ISO Heparin results in decreased expression of EGFR mRNA; Heparin results in decreased expression of EGFR protein
Heparin results in increased phosphorylation of EGFR protein		 CTD PMID:16475731 PMID:16556679 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA] CTD PMID:16401727 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G F10 coagulation factor X decreases activity ISO
EXP		 Heparin results in decreased activity of F10 protein CTD PMID:8950779 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II multiple interactions
decreases expression
increases expression		 ISO F2 protein promotes the reaction [Heparin results in increased abundance of Nitric Oxide]; Heparin deficiency results in increased cleavage of and results in increased activity of F2 protein; Heparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]; Heparin inhibits the reaction [F2 protein affects the localization of SELP protein]; Heparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein]; Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]; Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]
Heparin results in increased expression of [F2 protein binds to SERPINC1 protein]
Heparin results in decreased expression of F2 protein
Heparin deficiency results in increased expression of F2 protein; Heparin results in increased expression of F2 protein		 CTD PMID:7509996 PMID:7895349 PMID:8408661 PMID:9740346 PMID:11869846 More... NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO Heparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein] CTD PMID:19468011 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heparin results in increased expression of FAS protein CTD PMID:15205081 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fcgr2a Fc gamma receptor 2A affects binding ISO [Heparin binds to PF4 protein] which binds to FCGR2A protein CTD PMID:8282825 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fga fibrinogen alpha chain increases cleavage ISO Heparin deficiency results in increased cleavage of FGA protein CTD PMID:7895349 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions
affects binding		 ISO
EXP		 [Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein; Heparin analog promotes the reaction [FGF1 protein binds to FGF1 protein]
[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein
Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]; Heparin promotes the reaction [FGF1 protein results in increased expression of FGF1 protein]
Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]; Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]		 CTD PMID:1379594 PMID:8576258 PMID:10336501 PMID:10860838 PMID:14966081 More... NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf10 fibroblast growth factor 10 multiple interactions ISO Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein] CTD PMID:15632068 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf19 fibroblast growth factor 19 affects binding
multiple interactions		 ISO Heparin binds to FGF19 protein
Heparin promotes the reaction [FGF19 protein binds to FGFR4 protein]		 CTD PMID:10525310 PMID:14730967 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Fgf2 fibroblast growth factor 2 affects binding
decreases expression
multiple interactions
affects activity		 ISO
EXP		 Heparin binds to FGF2 protein; Heparin binds to FGFR1 protein binds to FGF2 protein
Heparin results in decreased expression of FGF2 protein
[Heparin binds to FGFR2 protein alternative form] which binds to FGF2 protein
Heparin affects the reaction [FGF2 protein binds to FGFR4 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
Heparin affects the activity of FGF2 protein
Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]; Heparin promotes the reaction [FGFR2 protein binds to FGF2 protein]		 CTD PMID:1373495 PMID:1379594 PMID:8441232 PMID:10336501 PMID:10860838 More... NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf23 fibroblast growth factor 23 increases activity ISO Heparin analog results in increased activity of FGF23 protein CTD PMID:16081635 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fgf3 fibroblast growth factor 3 affects activity ISO Heparin affects the activity of FGF3 protein CTD PMID:7592624 NCBI chr 1:200,001,261...200,005,187
Ensembl chr 1:200,001,261...200,005,187 		JBrowse link
G Fgf4 fibroblast growth factor 4 multiple interactions ISO Heparin binds to and results in increased activity of FGF4 protein CTD PMID:11486033 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466 		JBrowse link
G Fgf5 fibroblast growth factor 5 affects activity ISO Heparin affects the activity of FGF5 protein CTD PMID:8386828 NCBI chr14:11,325,334...11,346,570
Ensembl chr14:11,325,334...11,345,997 		JBrowse link
G Fgf7 fibroblast growth factor 7 affects binding EXP [Heparin binds to FGFR2 protein alternative form] which binds to FGF7 protein CTD PMID:10860838 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects binding
multiple interactions		 ISO Heparin binds to FGFR1 protein binds to FGF2 protein
Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]; Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]		 CTD PMID:1379594 PMID:15096041 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions
affects binding
affects activity		 ISO
EXP		 [Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein; Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein]
[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein; [Heparin binds to FGFR2 protein alternative form] which binds to FGF2 protein; [Heparin binds to FGFR2 protein alternative form] which binds to FGF7 protein
Heparin promotes the reaction [FGFR2 protein binds to FGF2 protein]
Heparin affects the activity of FGFR2 protein		 CTD PMID:1373495 PMID:10860838 PMID:15632068 PMID:16219767 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects activity
multiple interactions		 ISO Heparin affects the activity of FGFR3 protein
Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]		 CTD PMID:1379594 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects binding
multiple interactions		 ISO
EXP		 Heparin analog binds to FGFR4 protein
Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]; Heparin affects the reaction [FGF2 protein binds to FGFR4 protein]
Heparin promotes the reaction [FGF19 protein binds to FGFR4 protein]; Heparin promotes the reaction [FGFR4 protein binds to FGFR4 protein]		 CTD PMID:10336501 PMID:10525310 PMID:10736564 PMID:11278860 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
multiple interactions		 ISO
EXP		 Heparin results in increased expression of FOS protein
Heparin results in decreased expression of FOS mRNA
Heparin inhibits the reaction [4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in increased expression of FOS mRNA]		 CTD PMID:2099192 PMID:9083085 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein] CTD PMID:16259952 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase affects degradation ISO GNS affects the degradation of Heparin CTD PMID:3391615 NCBI chr 7:56,889,139...56,923,170
Ensembl chr 7:56,889,232...56,923,151 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]] CTD PMID:31813902 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gzmb granzyme B multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA] CTD PMID:16401727 NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
decreases secretion
multiple interactions		 ISO Heparin results in decreased expression of HAMP mRNA
Heparin results in decreased secretion of HAMP protein modified form
Heparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]		 CTD PMID:25633564 PMID:25686467 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions
affects binding
increases expression		 ISO Heparin promotes the reaction [HGF protein binds to and results in increased activity of MET protein]
HGF protein binds to Heparin
Heparin results in increased expression of HGF protein		 CTD PMID:9083085 PMID:18243369 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Heparin inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMOX1 mRNA] CTD PMID:31813902 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpse heparanase multiple interactions ISO [Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate CTD PMID:17121850 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Hrg histidine-rich glycoprotein multiple interactions ISO Heparin inhibits the reaction [Zinc results in increased activity of HRG protein] CTD PMID:8690451 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389 		JBrowse link
G Igsf10 immunoglobulin superfamily, member 10 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA] CTD PMID:16401727 NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions		 ISO
EXP		 Heparin results in increased expression of IL6 protein
Heparin analog results in increased secretion of IL6 protein
Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]		 CTD PMID:16391376 PMID:16401727 PMID:25633564 PMID:26476401 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M decreases expression
increases expression		 ISO Heparin results in decreased expression of ITGAM protein
Heparin results in increased expression of ITGAM protein		 CTD PMID:8595612 PMID:8993250 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Heparin results in decreased expression of ITGAX protein CTD PMID:8993250 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Heparin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:1730747 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA] CTD PMID:16401727 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Krt18 keratin 18 increases expression ISO Heparin results in increased expression of KRT18 protein CTD PMID:15671997 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Ldhb lactate dehydrogenase B decreases expression EXP Heparin results in decreased expression of LDHB protein CTD PMID:17488504 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [etofibrate co-treated with Heparin] results in increased secretion of LPL protein CTD PMID:3179329 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:14966081 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein] CTD PMID:14966081 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity		 ISO
EXP		 Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK1 protein]
Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]
Heparin results in increased activity of MAPK1 protein		 CTD PMID:14966081 PMID:16556679 PMID:18057711 PMID:19937756 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity		 ISO
EXP		 Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK3 protein]
Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
Heparin results in increased activity of MAPK3 protein		 CTD PMID:14966081 PMID:16556679 PMID:18057711 PMID:19937756 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Heparin promotes the reaction [MAPT protein binds to MAPT protein]; Mercuric Chloride promotes the reaction [Heparin promotes the reaction [MAPT protein binds to MAPT protein]] CTD PMID:20665688 PMID:31678113 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mcpt4 mast cell protease 4 increases activity EXP Heparin increases activity of Mcpt4 protein RGD PMID:11896050 RGD:633287 NCBI chr15:29,501,595...29,504,216
Ensembl chr15:29,501,595...29,504,214 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO Heparin promotes the reaction [HGF protein binds to and results in increased activity of MET protein] CTD PMID:9083085 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mif macrophage migration inhibitory factor affects binding ISO MIF protein binds to Heparin CTD PMID:26852939 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases activity ISO Heparin results in decreased activity of MMP1 protein CTD PMID:10958381 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO Heparin analog results in decreased expression of MMP14 mRNA CTD PMID:26476401 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Heparin results in decreased activity of MMP2 protein CTD PMID:10958381 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
increases expression
multiple interactions		 ISO Heparin results in decreased activity of MMP9 protein
Heparin results in increased expression of MMP9 mRNA; Heparin results in increased expression of MMP9 protein
Heparin results in increased metabolism of and results in increased activity of MMP9 protein		 CTD PMID:10958381 PMID:14630814 PMID:16190367 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Heparin inhibits the reaction [4-amino-TEMPO inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Cadaverine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]] CTD PMID:34085520 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Msn moesin increases expression EXP Heparin results in increased expression of MSN protein CTD PMID:17488504 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression		 ISO
EXP		 Heparin results in increased expression of MYC protein
Heparin results in decreased expression of MYC mRNA		 CTD PMID:2099192 PMID:11787776 PMID:16475731 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein] CTD PMID:16259952 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Heparin analog results in increased expression of NFE2L2 mRNA CTD PMID:26476401 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Park7 Parkinsonism associated deglycase increases expression EXP Heparin results in increased expression of PARK7 protein CTD PMID:17488504 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Heparin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein] CTD PMID:30377735 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B affects expression EXP Heparin affects the expression of PDGFB protein CTD PMID:8441232 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression ISO Heparin results in decreased expression of PDGFRA mRNA CTD PMID:16945567 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta decreases expression EXP Heparin results in decreased expression of PDHB protein CTD PMID:17488504 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pf4 platelet factor 4 affects binding
increases secretion		 ISO [Heparin binds to PF4 protein] which binds to FCGR2A protein; Heparin binds to PF4 protein
Heparin results in increased secretion of PF4 protein		 CTD PMID:2437338 PMID:2709525 PMID:8282825 PMID:20162249 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Pitpna phosphatidylinositol transfer protein, alpha increases expression EXP Heparin results in increased expression of PITPNA protein CTD PMID:17488504 NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Heparin results in increased expression of PLAT mRNA; Heparin results in increased expression of PLAT protein CTD PMID:14630814 PMID:16190367 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Heparin analog results in decreased expression of PLAU mRNA CTD PMID:26476401 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plg plasminogen multiple interactions ISO Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein] CTD PMID:17384413 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Ppbp pro-platelet basic protein increases secretion ISO Heparin results in increased secretion of PPBP protein CTD PMID:2437338 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases activity ISO Heparin deficiency results in increased activity of PROC protein CTD PMID:7895349 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases activity
decreases expression		 ISO Heparin analog results in decreased activity of PSMB5 protein
Heparin analog results in decreased expression of PSMB5 mRNA		 CTD PMID:26476401 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440 		JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO Heparin analog results in decreased expression of PSMB6 mRNA CTD PMID:26476401 NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586 		JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO Heparin analog results in decreased expression of PSMB7 mRNA CTD PMID:26476401 NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937 		JBrowse link
G Psme1 proteasome activator subunit 1 increases expression EXP Heparin results in increased expression of PSME1 protein CTD PMID:17488504 NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA] CTD PMID:16401727 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO Heparin results in decreased phosphorylation of PTK2 protein CTD PMID:18674534 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin decreases phosphorylation ISO Heparin results in decreased phosphorylation of PXN protein CTD PMID:18674534 NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA] CTD PMID:16401727 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Heparin analog results in decreased expression of and results in decreased phosphorylation of RB1 protein CTD PMID:20201787 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Heparin inhibits the reaction [arsenite affects the localization of RELA protein]; Heparin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:10843908 PMID:26677073 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G S100a1 S100 calcium binding protein A1 affects expression EXP Heparin affects the expression of S100A1 protein CTD PMID:12186470 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544 		JBrowse link
G S100a6 S100 calcium binding protein A6 affects expression
increases expression		 EXP Heparin affects the expression of S100A6 protein
Heparin results in increased expression of S100A6 protein		 CTD PMID:12186470 PMID:17488504 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180 		JBrowse link
G S100b S100 calcium binding protein B affects expression EXP Heparin affects the expression of S100B protein CTD PMID:12186470 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Sdc1 syndecan 1 decreases expression ISO Heparin analog results in decreased expression of SDC1 mRNA CTD PMID:26476401 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdc2 syndecan 2 decreases expression ISO Heparin analog results in decreased expression of SDC2 mRNA CTD PMID:26476401 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081 		JBrowse link
G Sdc4 syndecan 4 increases expression ISO Heparin analog results in increased expression of SDC4 mRNA CTD PMID:26476401 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sell selectin L decreases expression
increases expression		 ISO Heparin results in decreased expression of SELL protein
Heparin results in increased expression of SELL protein		 CTD PMID:8595612 PMID:8993250 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Selp selectin P multiple interactions
increases expression		 ISO Heparin inhibits the reaction [F2 protein affects the localization of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]
Heparin results in increased expression of SELP protein		 CTD PMID:9740346 PMID:10544909 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Septin2 septin 2 increases expression EXP Heparin results in increased expression of SEPTIN2 protein CTD PMID:17488504 NCBI chr 9:94,018,141...94,051,386
Ensembl chr 9:94,018,208...94,051,386 		JBrowse link
G Serpinc1 serpin family C member 1 decreases expression
multiple interactions		 ISO Heparin deficiency results in decreased expression of SERPINC1 protein; Heparin results in decreased expression of SERPINC1 protein
Heparin results in increased expression of [F2 protein binds to SERPINC1 protein]
Heparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]		 CTD PMID:73932 PMID:7895349 PMID:8122184 PMID:11869846 PMID:16961586 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein] CTD PMID:16401727 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions EXP Heparin promotes the reaction [Doxorubicin results in increased secretion of SFRP1 protein] CTD PMID:30377735 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA] CTD PMID:16401727 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883 		JBrowse link
G Slk STE20-like kinase multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA] CTD PMID:16401727 NCBI chr 1:246,473,712...246,529,643
Ensembl chr 1:246,473,712...246,526,530 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression EXP Heparin results in increased expression of STIP1 protein CTD PMID:17488504 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Tagln2 transgelin 2 decreases expression EXP Heparin results in decreased expression of TAGLN2 protein CTD PMID:17488504 NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972 		JBrowse link
G Tfrc transferrin receptor multiple interactions
decreases expression		 EXP
ISO		 Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]
Heparin results in decreased expression of TFRC protein		 CTD PMID:16401727 PMID:25633564 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Heparin results in decreased expression of TGFB1 mRNA CTD PMID:15149336 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO Heparin inhibits the reaction [TNF protein affects the localization of RELA protein]
Heparin results in increased expression of TNF protein		 CTD PMID:10843908 PMID:17162433 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Heparin analog results in decreased expression of TP53 protein CTD PMID:20201787 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A affects binding ISO Heparin binds to VEGFA protein alternative form CTD PMID:20376344 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
hyaluronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] CTD PMID:19047049 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases export
multiple interactions		 ISO ABCC5 protein results in increased export of Hyaluronic Acid
[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]		 CTD PMID:23978416 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abra actin-binding Rho activating protein multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ABRA protein] CTD PMID:23178681 NCBI chr 7:72,970,187...72,974,255
Ensembl chr 7:72,970,186...72,974,255 		JBrowse link
G Acan aggrecan multiple interactions ISO [Hyaluronic Acid co-treated with resveratrol] results in increased expression of ACAN mRNA CTD PMID:23595953 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACAT2 protein]
Hyaluronic Acid analog results in decreased expression of ACAT2 protein		 CTD PMID:23178681 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Aco2 aconitase 2 decreases expression EXP Hyaluronic Acid analog results in decreased expression of ACO2 protein CTD PMID:23178681 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [CD44 protein affects the abundance of Hyaluronic Acid] affects the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:31285260 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actb actin, beta multiple interactions
affects expression		 EXP Hyaluronic Acid analog affects the reaction [Hydrogen Peroxide results in decreased expression of ACTB protein]
Hyaluronic Acid analog affects the expression of ACTB protein		 CTD PMID:23178681 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACTC1 protein] CTD PMID:23178681 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523 		JBrowse link
G Actg2 actin gamma 2, smooth muscle multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACTG2 protein]
Hyaluronic Acid analog results in decreased expression of ACTG2 protein		 CTD PMID:23178681 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465 		JBrowse link
G Actr3 actin related protein 3 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACTR3 protein] CTD PMID:23178681 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein] CTD PMID:23178681 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin increases abundance ISO ALB protein results in increased abundance of Hyaluronic Acid CTD PMID:16642209 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Anxa1 annexin A1 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of ANXA1 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ANXA1 protein]		 CTD PMID:23178681 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa2 annexin A2 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ANXA2 protein] CTD PMID:23178681 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Anxa3 annexin A3 decreases expression EXP Hyaluronic Acid analog results in decreased expression of ANXA3 protein CTD PMID:23178681 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Anxa4 annexin A4 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ANXA4 protein] CTD PMID:23178681 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Anxa5 annexin A5 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ANXA5 protein]
Hyaluronic Acid analog results in decreased expression of ANXA5 protein		 CTD PMID:23178681 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 increases expression
multiple interactions		 EXP Hyaluronic Acid analog results in increased expression of ARHGAP29 protein
[Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in increased expression of ARHGAP29 protein		 CTD PMID:23178681 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases cleavage		 EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of ATIC protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATIC protein]		 CTD PMID:23178681 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP5F1A protein]
Hyaluronic Acid analog results in decreased expression of ATP5F1A protein		 CTD PMID:23178681 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression EXP Hyaluronic Acid analog results in decreased expression of ATP5F1B protein CTD PMID:23178681 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] CTD PMID:19047049 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression
multiple interactions		 EXP Hyaluronic Acid results in increased expression of BNIP3 protein
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein]		 CTD PMID:27082295 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Calr calreticulin decreases expression EXP Hyaluronic Acid analog results in decreased expression of CALR protein CTD PMID:23178681 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Calu calumenin decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of CALU protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CALU protein]		 CTD PMID:23178681 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAMK1 protein]
Hyaluronic Acid analog results in decreased expression of CAMK1 protein		 CTD PMID:23178681 NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAR3 protein]
Hyaluronic Acid analog results in decreased expression of CAR3 protein		 CTD PMID:23178681 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Casp1 caspase 1 increases cleavage EXP Hyaluronic Acid results in increased cleavage of CASP1 protein CTD PMID:33383130 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA] CTD PMID:17879260 PMID:19047049 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA] CTD PMID:17879260 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein CTD PMID:20237495 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased degradation of Hyaluronic Acid] CTD PMID:23692848 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO Hyaluronic Acid analog results in increased secretion of CCL5 protein CTD PMID:9278343 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCT2 protein]
Hyaluronic Acid analog results in decreased expression of CCT2 protein		 CTD PMID:23178681 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCT4 protein] CTD PMID:23178681 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCT5 protein]
Hyaluronic Acid analog results in decreased expression of CCT5 protein		 CTD PMID:23178681 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions
increases expression
affects binding		 ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein; [[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein; [[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein; [CD44 protein affects the abundance of Hyaluronic Acid] affects the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAU mRNA; [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAU protein; [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR mRNA; [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR protein; [Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein; Hyaluronic Acid analog binds to and results in increased activity of CD44 protein; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein]
Hyaluronic Acid analog affects the localization of [MAP3K1 protein binds to CD44 protein]; Hyaluronic Acid analog promotes the reaction [MAP3K1 protein binds to CD44 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of CD44 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of CD44 protein]; Tetradecanoylphorbol Acetate promotes the reaction [CD44 protein binds to Hyaluronic Acid]; Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CD44 protein binds to Hyaluronic Acid]]
Hyaluronic Acid metabolite results in increased expression of CD44 mRNA; Hyaluronic Acid metabolite results in increased expression of CD44 protein		 CTD PMID:9929743 PMID:12402308 PMID:19047049 PMID:20159036 PMID:23692848 More... NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cfl1 cofilin 1 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CFL1 protein]
Hyaluronic Acid analog results in decreased expression of CFL1 protein		 CTD PMID:23178681 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO [Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein CTD PMID:20237495 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cftr CF transmembrane conductance regulator increases export
multiple interactions		 ISO CFTR protein results in increased export of Hyaluronic Acid
Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]; xanthohumol inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]		 CTD PMID:23978416 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cnn3 calponin 3 decreases expression EXP Hyaluronic Acid analog results in decreased expression of CNN3 protein CTD PMID:23178681 NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions ISO [Hyaluronic Acid co-treated with resveratrol] results in increased expression of COL2A1 mRNA CTD PMID:23595953 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cops4 COP9 signalosome subunit 4 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of COPS4 protein] CTD PMID:23178681 NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887 		JBrowse link
G Coq7 coenzyme Q7, hydroxylase multiple interactions
increases expression		 EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] affects the expression of COQ7 protein
Hyaluronic Acid analog results in increased expression of COQ7 protein		 CTD PMID:23178681 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158 		JBrowse link
G Cpox coproporphyrinogen oxidase multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CPOX protein] CTD PMID:23178681 NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in decreased expression of CTH protein CTD PMID:23178681 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein; [[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] CTD PMID:19047049 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Hyaluronic Acid inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CYP1A1 mRNA] CTD PMID:30856093 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dld dihydrolipoamide dehydrogenase decreases expression EXP Hyaluronic Acid analog results in decreased expression of DLD protein CTD PMID:23178681 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of DNAJA1 protein CTD PMID:23178681 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Dstn destrin, actin depolymerizing factor multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of DSTN protein]
Hyaluronic Acid analog results in decreased expression of DSTN protein		 CTD PMID:23178681 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379 		JBrowse link
G Eci2 enoyl-CoA delta isomerase 2 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in increased expression of ECI2 protein] CTD PMID:23178681 NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781 		JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of EEF1G protein] CTD PMID:23178681 NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of EEF2 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of EEF2 protein]		 CTD PMID:23178681 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid] CTD PMID:21520325 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation ISO Hyaluronic Acid results in increased phosphorylation of EIF4E protein CTD PMID:16864594 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eno1 enolase 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of ENO1 protein CTD PMID:23178681 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein; [[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein; [[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein; [Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] CTD PMID:19047049 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP Hyaluronic Acid analog results in decreased expression of ERP29 protein CTD PMID:23178681 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Esd esterase D multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESD protein] CTD PMID:23178681 NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144 		JBrowse link
G Ezr ezrin multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of EZR protein] CTD PMID:23178681 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fgf23 fibroblast growth factor 23 increases activity ISO Hyaluronic Acid analog results in increased activity of FGF23 protein CTD PMID:16081635 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fgf7 fibroblast growth factor 7 increases chemical synthesis EXP FGF7 protein results in increased chemical synthesis of Hyaluronic Acid CTD PMID:14506240 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fgg fibrinogen gamma chain increases expression
multiple interactions		 EXP Hyaluronic Acid analog results in increased expression of FGG protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in increased expression of FGG protein]		 CTD PMID:23178681 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of FKBP4 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of FKBP4 protein]		 CTD PMID:23178681 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of FSCN1 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of FSCN1 protein]		 CTD PMID:23178681 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases chemical synthesis		 ISO [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid] CTD PMID:21520325 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fubp1 far upstream element binding protein 1 multiple interactions
affects expression		 EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in increased expression of FUBP1 protein
Hyaluronic Acid analog affects the expression of FUBP1 protein		 CTD PMID:23178681 NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602 		JBrowse link
G Gab1 GRB2-associated binding protein 1 increases phosphorylation ISO Hyaluronic Acid results in increased phosphorylation of GAB1 protein CTD PMID:16864594 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Gdi1 GDP dissociation inhibitor 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of GDI1 protein] CTD PMID:23178681 NCBI chr  X:152,087,611...152,094,274
Ensembl chr  X:152,087,444...152,094,272 		JBrowse link
G Glrx3 glutaredoxin 3 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of GLRX3 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of GLRX3 protein]		 CTD PMID:23178681 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Gnb1 G protein subunit beta 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of GNB1 protein] CTD PMID:23178681 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124 		JBrowse link
G Gnb2 G protein subunit beta 2 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of GNB2 protein] CTD PMID:23178681 NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of GOT1 protein CTD PMID:23178681 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gsdmd gasdermin D increases expression
increases cleavage		 EXP Hyaluronic Acid results in increased expression of GSDMD mRNA
Hyaluronic Acid results in increased cleavage of GSDMD protein		 CTD PMID:33383130 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsn gelsolin multiple interactions
decreases expression		 EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in decreased expression of GSN protein
Hyaluronic Acid analog results in decreased expression of GSN protein		 CTD PMID:23178681 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gucy2f guanylate cyclase 2F multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of GUCY2F protein] CTD PMID:23178681 NCBI chr  X:105,710,356...105,808,183
Ensembl chr  X:105,710,356...105,808,183 		JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Hyaluronic Acid metabolite results in increased expression of HAS1 mRNA; Hyaluronic Acid metabolite results in increased expression of HAS1 protein CTD PMID:31226360 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397 		JBrowse link
G Has2 hyaluronan synthase 2 increases chemical synthesis
affects abundance
multiple interactions		 ISO HAS2 protein results in increased chemical synthesis of Hyaluronic Acid
HAS2 protein affects the abundance of Hyaluronic Acid
[IL1B protein results in increased expression of HAS2 protein] which results in increased chemical synthesis of Hyaluronic Acid		 CTD PMID:11318944 PMID:31285260 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Has3 hyaluronan synthase 3 multiple interactions
increases expression		 ISO [HAS3 protein affects the susceptibility to Carbon Tetrachloride] which affects the abundance of Hyaluronic Acid; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased abundance of Hyaluronic Acid]
Hyaluronic Acid metabolite results in increased expression of HAS3 mRNA; Hyaluronic Acid metabolite results in increased expression of HAS3 protein		 CTD PMID:27042213 PMID:31226360 NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 EXP Hyaluronic Acid results in increased expression of HIF1A protein
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]		 CTD PMID:27082295 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMBS protein]
Hyaluronic Acid analog results in decreased expression of HMBS protein		 CTD PMID:23178681 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor multiple interactions ISO Hyaluronic Acid binds to and results in increased activity of HMMR protein CTD PMID:16864594 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of HNRNPA2B1 protein CTD PMID:23178681 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HNRNPH1 protein]
Hyaluronic Acid analog results in decreased expression of HNRNPH1 protein		 CTD PMID:23178681 NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression EXP Hyaluronic Acid analog results in decreased expression of HNRNPK protein CTD PMID:23178681 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSP90AA1 protein] CTD PMID:23178681 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of HSP90B1 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSP90B1 protein]		 CTD PMID:23178681 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects expression
multiple interactions		 EXP Hyaluronic Acid analog affects the expression of HSPA5 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSPA5 protein]		 CTD PMID:23178681 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSPA8 protein]
Hyaluronic Acid analog results in decreased expression of HSPA8 protein		 CTD PMID:23178681 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of HSPB1 protein CTD PMID:23178681 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of HSPD1 protein CTD PMID:23178681 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of IDH1 protein CTD PMID:23178681 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression EXP Hyaluronic Acid analog results in decreased expression of IDH2 protein CTD PMID:23178681 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDO1 protein]
Hyaluronic Acid analog results in decreased expression of IDO1 protein		 CTD PMID:23178681 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Hyaluronic Acid inhibits the reaction [Acetaminophen results in increased expression of IFNG protein] CTD PMID:18237725 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B increases secretion ISO Hyaluronic Acid analog results in increased secretion of IL12B protein CTD PMID:9278343 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta increases abundance
increases expression
multiple interactions		 ISO
EXP		 IL1B protein results in increased abundance of Hyaluronic Acid
Hyaluronic Acid results in increased expression of IL1B mRNA
[Hyaluronic Acid co-treated with resveratrol] results in decreased expression of IL1B mRNA
Hyaluronic Acid metabolite results in increased expression of IL1B mRNA; Hyaluronic Acid metabolite results in increased expression of IL1B protein
[acetic anhydride results in increased acetylation of Hyaluronic Acid metabolite] which results in increased secretion of IL1B protein; [Butyrates results in increased acylation of Hyaluronic Acid metabolite] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL1B protein]; [Butyrates results in increased acylation of Hyaluronic Acid metabolite] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; [Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL1B protein; [IL1B protein results in increased expression of HAS2 protein] which results in increased chemical synthesis of Hyaluronic Acid; [Lipopolysaccharides results in decreased activity of TLR4 protein] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL1B protein]; Sulindac inhibits the reaction [IL1B protein results in increased abundance of Hyaluronic Acid]		 CTD PMID:11318944 PMID:23595953 PMID:23692848 PMID:25053413 PMID:33383130 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [acetic anhydride results in increased acetylation of Hyaluronic Acid metabolite] which results in increased secretion of IL6 protein; [Butyrates results in increased acylation of Hyaluronic Acid metabolite] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL6 protein]; [Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL6 protein CTD PMID:25053413 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression ISO Hyaluronic Acid results in increased expression of IRAK3 protein CTD PMID:15728517 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Hyaluronic Acid] CTD PMID:25561734 NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO Hyaluronic Acid analog results in increased phosphorylation of JUN protein CTD PMID:12402308 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Krt10 keratin 10 multiple interactions
increases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of KRT10 protein]
Hyaluronic Acid analog results in increased expression of KRT10 protein		 CTD PMID:23178681 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701 		JBrowse link
G Lap3 leucine aminopeptidase 3 decreases expression EXP Hyaluronic Acid analog results in decreased expression of LAP3 protein CTD PMID:23178681 NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359 		JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of LDHB protein] CTD PMID:23178681 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Lgals1 galectin 1 increases expression
multiple interactions		 EXP Hyaluronic Acid analog results in increased expression of LGALS1 protein
Hyaluronic Acid analog affects the reaction [Hydrogen Peroxide results in decreased expression of LGALS1 protein]		 CTD PMID:23178681 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lmna lamin A/C multiple interactions
increases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of LMNA protein]
Hyaluronic Acid analog results in increased expression of LMNA protein		 CTD PMID:23178681 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of LRPAP1 protein]
Hyaluronic Acid analog results in decreased expression of LRPAP1 protein		 CTD PMID:23178681 NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases cleavage		 EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO Hyaluronic Acid analog results in increased phosphorylation of MAP2K1 protein CTD PMID:12402308 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO Hyaluronic Acid analog results in increased phosphorylation of MAP2K2 protein CTD PMID:12402308 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions ISO Hyaluronic Acid analog affects the localization of [MAP3K1 protein binds to CD44 protein]; Hyaluronic Acid analog promotes the reaction [MAP3K1 protein binds to CD44 protein]; Hyaluronic Acid analog results in increased phosphorylation of and results in increased activity of MAP3K1 protein CTD PMID:20159036 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 multiple interactions ISO MAP3K3 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid] CTD PMID:20633555 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Hyaluronic Acid analog results in increased phosphorylation of MAPK1 protein
MAPK1 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]; U 0126 inhibits the reaction [Hyaluronic Acid analog results in increased phosphorylation of MAPK1 protein]		 CTD PMID:12402308 PMID:20159036 PMID:20633555 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Hyaluronic Acid analog results in increased phosphorylation of MAPK3 protein
MAPK3 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]; U 0126 inhibits the reaction [Hyaluronic Acid analog results in increased phosphorylation of MAPK3 protein]		 CTD PMID:12402308 PMID:20159036 PMID:20633555 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO MAPK7 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid] CTD PMID:20633555 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mfn1 mitofusin 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of MFN1 protein CTD PMID:23178681 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Hyaluronic Acid co-treated with Resveratrol] results in decreased expression of MMP1 mRNA CTD PMID:23595953 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression		 ISO [Hyaluronic Acid co-treated with resveratrol] results in decreased expression of MMP13 mRNA
Hyaluronic Acid metabolite results in increased expression of MMP13 mRNA; Hyaluronic Acid metabolite results in increased expression of MMP13 protein		 CTD PMID:23595953 PMID:23692848 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 affects activity ISO Hyaluronic Acid affects the activity of MMP2 protein CTD PMID:15597151 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [Hyaluronic Acid co-treated with resveratrol] results in decreased expression of MMP3 mRNA CTD PMID:23595953 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects activity ISO Hyaluronic Acid affects the activity of MMP9 protein CTD PMID:15597151 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:14697411 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 decreases expression EXP Hyaluronic Acid analog results in decreased expression of MRPS7 protein CTD PMID:23178681 NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of MUS81 protein]
Hyaluronic Acid analog results in decreased expression of MUS81 protein		 CTD PMID:23178681 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Myl12a myosin light chain 12A multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of MYL12A protein]
Hyaluronic Acid analog results in decreased expression of MYL12A protein		 CTD PMID:23178681 NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580 		JBrowse link
G Myl12b myosin light chain 12B decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of MYL12B protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of MYL12B protein]		 CTD PMID:23178681 NCBI chr 9:110,873,855...110,888,187 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Hyaluronic Acid metabolite results in increased activity of [NFKB1 protein binds to RELA protein]
[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein]		 CTD PMID:17879260 PMID:23692848 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation		 ISO
EXP		 [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein]
Hyaluronic Acid results in decreased phosphorylation of NFKBIA protein		 CTD PMID:17879260 PMID:33383130 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression EXP Hyaluronic Acid results in increased expression of NLRP3 mRNA; Hyaluronic Acid results in increased expression of NLRP3 protein CTD PMID:33383130 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of NME1 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NME1 protein]		 CTD PMID:23178681 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NME2 protein]
Hyaluronic Acid analog results in decreased expression of NME2 protein		 CTD PMID:23178681 NCBI chr10:78,898,097...78,903,600
Ensembl chr10:78,897,770...78,903,538 		JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
increases expression		 ISO Hyaluronic Acid affects the expression of NOS2 mRNA
Hyaluronic Acid metabolite results in increased expression of NOS2 mRNA; Hyaluronic Acid metabolite results in increased expression of NOS2 protein		 CTD PMID:15597151 PMID:23692848 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO Hyaluronic Acid results in decreased expression of NR1D1 mRNA CTD PMID:17075855 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nrxn1 neurexin 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 protein] CTD PMID:23178681 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Optn optineurin multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of OPTN protein] CTD PMID:23178681 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Pde4d phosphodiesterase 4D decreases expression EXP Hyaluronic Acid analog results in decreased expression of PDE4D protein CTD PMID:23178681 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP Hyaluronic Acid analog results in decreased expression of PDIA3 protein CTD PMID:23178681 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PDIA6 protein] CTD PMID:23178681 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PGAM1 protein] CTD PMID:23178681 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of PGK1 protein CTD PMID:23178681 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pgls 6-phosphogluconolactonase multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PGLS protein] CTD PMID:23178681 NCBI chr16:18,300,317...18,305,803
Ensembl chr16:18,300,317...18,305,803 		JBrowse link
G Phb1 prohibitin 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PHB1 protein] CTD PMID:23178681 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PHGDH protein] CTD PMID:23178681 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases phosphorylation ISO Hyaluronic Acid results in increased phosphorylation of PIK3CA protein CTD PMID:16864594 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pitpna phosphatidylinositol transfer protein, alpha multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PITPNA protein] CTD PMID:23178681 NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAU mRNA; [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAU protein CTD PMID:12402308 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR mRNA; [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR protein CTD PMID:12402308 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pls3 plastin 3 multiple interactions
increases expression		 EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in increased expression of PLS3 protein
Hyaluronic Acid analog results in increased expression of PLS3 protein		 CTD PMID:23178681 NCBI chr  X:111,589,193...111,683,908
Ensembl chr  X:111,589,254...111,683,891 		JBrowse link
G Ppia peptidylprolyl isomerase A multiple interactions
decreases expression		 EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in decreased expression of PPIA protein
Hyaluronic Acid analog results in decreased expression of PPIA protein		 CTD PMID:23178681 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha multiple interactions EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in increased expression of PPP1CA protein CTD PMID:23178681 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Prdx1 peroxiredoxin 1 affects expression EXP Hyaluronic Acid analog affects the expression of PRDX1 protein CTD PMID:23178681 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx2 peroxiredoxin 2 decreases expression EXP Hyaluronic Acid analog results in decreased expression of PRDX2 protein CTD PMID:23178681 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
affects expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PRDX6 protein]
Hyaluronic Acid analog affects the expression of PRDX6 protein		 CTD PMID:23178681 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Prph peripherin decreases expression EXP Hyaluronic Acid analog results in decreased expression of PRPH protein CTD PMID:23178681 NCBI chr 7:130,218,149...130,222,136
Ensembl chr 7:130,218,357...130,222,136 		JBrowse link
G Psmb1 proteasome 20S subunit beta 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in increased expression of PSMB1 protein] CTD PMID:23178681 NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PSMC2 protein] CTD PMID:23178681 NCBI chr 4:13,255,851...13,270,102
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in increased expression of PSMC4 protein]
Hyaluronic Acid analog results in decreased expression of PSMC4 protein		 CTD PMID:23178681 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 decreases expression EXP Hyaluronic Acid analog results in decreased expression of PSMC5 protein CTD PMID:23178681 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of PTK2 protein] CTD PMID:23178681 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of RACK1 protein] CTD PMID:23178681 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Ran RAN, member RAS oncogene family multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of RAN protein]
Hyaluronic Acid analog results in decreased expression of RAN protein		 CTD PMID:23178681 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 ISO
EXP		 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein; [[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein]
Hyaluronic Acid results in increased phosphorylation of RELA protein
Hyaluronic Acid metabolite results in increased phosphorylation of RELA protein
Hyaluronic Acid metabolite results in increased activity of [NFKB1 protein binds to RELA protein]		 CTD PMID:17879260 PMID:19047049 PMID:23692848 PMID:31226360 PMID:33383130 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Renbp renin binding protein multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of RENBP protein] CTD PMID:23178681 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases phosphorylation ISO Hyaluronic Acid results in increased phosphorylation of ROCK1 protein CTD PMID:16864594 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rps12 ribosomal protein S12 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of RPS12 protein]
Hyaluronic Acid analog results in decreased expression of RPS12 protein		 CTD PMID:23178681 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014 		JBrowse link
G Scrn1 secernin 1 multiple interactions
decreases expression		 EXP [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in decreased expression of SCRN1 protein
Hyaluronic Acid analog results in decreased expression of SCRN1 protein		 CTD PMID:23178681 NCBI chr 4:83,632,125...83,694,225
Ensembl chr 4:83,632,131...83,693,852 		JBrowse link
G Septin11 septin 11 decreases expression
multiple interactions		 EXP Hyaluronic Acid analog results in decreased expression of SEPTIN11 protein
Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of SEPTIN11 protein]		 CTD PMID:23178681 NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853 		JBrowse link
G Septin2 septin 2 decreases expression EXP Hyaluronic Acid analog results in decreased expression of SEPTIN2 protein CTD PMID:23178681 NCBI chr 9:94,018,141...94,051,386
Ensembl chr 9:94,018,208...94,051,386 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions
affects expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of SERPINH1 protein]
Hyaluronic Acid analog affects the expression of SERPINH1 protein		 CTD PMID:23178681 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Slc25a11 solute carrier family 25 member 11 decreases expression EXP Hyaluronic Acid analog results in decreased expression of SLC25A11 protein CTD PMID:23178681 NCBI chr10:55,358,163...55,360,278
Ensembl chr10:55,357,597...55,360,410 		JBrowse link
G Slmap sarcolemma associated protein decreases expression EXP Hyaluronic Acid analog results in decreased expression of SLMAP protein CTD PMID:23178681 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid] CTD PMID:21520325 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride results in decreased activity of SMAD3 protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid] CTD PMID:21520325 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO Hyaluronic Acid analog results in increased expression of SNAI2 mRNA; Hyaluronic Acid analog results in increased expression of SNAI2 protein CTD PMID:20159036 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sncb synuclein, beta decreases expression EXP Hyaluronic Acid analog results in decreased expression of SNCB protein CTD PMID:23178681 NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of SOD1 protein CTD PMID:23178681 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod3 superoxide dismutase 3 affects binding
multiple interactions		 ISO SOD3 protein binds to Hyaluronic Acid
SOD3 protein inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] results in increased degradation of Hyaluronic Acid]		 CTD PMID:18165226 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of SORD protein] CTD PMID:23178681 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions ISO [Hyaluronic Acid co-treated with resveratrol] results in increased expression of SOX9 mRNA CTD PMID:23595953 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of SRC protein] CTD PMID:23178681 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stam2 signal transducing adaptor molecule 2 decreases expression EXP Hyaluronic Acid analog results in decreased expression of STAM2 protein CTD PMID:23178681 NCBI chr 3:37,186,145...37,234,810
Ensembl chr 3:37,186,145...37,234,812 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of STIP1 protein]
Hyaluronic Acid analog results in decreased expression of STIP1 protein		 CTD PMID:23178681 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Tcp1 t-complex 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of TCP1 protein] CTD PMID:23178681 NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [CD44 protein affects the abundance of Hyaluronic Acid] affects the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:31285260 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions
increases abundance		 ISO MAP3K3 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]; MAPK1 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]; MAPK3 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]; MAPK7 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid] CTD PMID:20633555 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression
multiple interactions		 ISO Hyaluronic Acid metabolite results in increased expression of TLR2 mRNA; Hyaluronic Acid metabolite results in increased expression of TLR2 protein
Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 protein]		 CTD PMID:23692848 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression
increases abundance		 ISO Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR4 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR4 protein]
Hyaluronic Acid metabolite results in increased expression of TLR4 mRNA; Hyaluronic Acid metabolite results in increased expression of TLR4 protein
TLR4 protein results in increased abundance of Hyaluronic Acid
[Lipopolysaccharides results in decreased activity of TLR4 protein] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of IL1B protein]		 CTD PMID:23692848 PMID:25053413 PMID:31226360 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
increases expression		 EXP
ISO		 [Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
[acetic anhydride results in increased acetylation of Hyaluronic Acid metabolite] which results in increased secretion of TNF protein; [Butyrates results in increased acylation of Hyaluronic Acid metabolite] inhibits the reaction [[Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of TNF protein]; [Hyaluronic Acid metabolite binds to Acetates] which results in increased secretion of TNF protein
TNF mRNA results in increased abundance of Hyaluronic Acid
Hyaluronic Acid metabolite results in increased expression of TNF mRNA; Hyaluronic Acid metabolite results in increased expression of TNF protein		 CTD PMID:14697411 PMID:23692848 PMID:25053413 PMID:25106431 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 affects binding
multiple interactions		 ISO TNFAIP6 protein modified form binds to Hyaluronic Acid
TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Hyaluronic Acid]		 CTD PMID:12401803 PMID:25561734 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tpm2 tropomyosin 2 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of TPM2 protein] CTD PMID:23178681 NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992 		JBrowse link
G Tpm3 tropomyosin 3 multiple interactions
decreases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of TPM3 protein]
Hyaluronic Acid analog results in decreased expression of TPM3 protein		 CTD PMID:23178681 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression EXP Hyaluronic Acid analog results in decreased expression of TPT1 protein CTD PMID:23178681 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of TUBB5 protein] CTD PMID:23178681 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Vcp valosin-containing protein multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of VCP protein] CTD PMID:23178681 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Hyaluronic Acid promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] CTD PMID:20067761 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin increases expression
multiple interactions
affects expression		 ISO
EXP		 Hyaluronic Acid analog results in increased expression of VIM protein
Hyaluronic Acid analog affects the reaction [Hydrogen Peroxide affects the expression of VIM protein]
Hyaluronic Acid analog affects the expression of VIM protein		 CTD PMID:20159036 PMID:23178681 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vps33a VPS33A core subunit of CORVET and HOPS complexes multiple interactions
increases expression		 EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of VPS33A protein]
Hyaluronic Acid analog results in increased expression of VPS33A protein		 CTD PMID:23178681 NCBI chr12:33,024,596...33,051,399
Ensembl chr12:33,024,650...33,051,393 		JBrowse link
G Wdr1 WD repeat domain 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of WDR1 protein] CTD PMID:23178681 NCBI chr14:72,258,032...72,291,768
Ensembl chr14:72,257,956...72,291,766 		JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 multiple interactions EXP Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of YARS1 protein] CTD PMID:23178681 NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833 		JBrowse link
keratan sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 increases chemical synthesis ISO B3GNT2 protein results in increased chemical synthesis of Keratan Sulfate CTD PMID:12218059 NCBI chr14:96,808,473...96,833,674
Ensembl chr14:96,806,664...96,835,273 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases chemical synthesis ISO B4GALT1 protein results in increased chemical synthesis of Keratan Sulfate CTD PMID:12218059 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Chst5 carbohydrate sulfotransferase 5 multiple interactions ISO CHST6 protein results in increased sulfation of and results in increased chemical synthesis of Keratan Sulfate
CHST5 protein results in increased sulfation of and results in increased chemical synthesis of Keratan Sulfate		 CTD PMID:12218059 NCBI chr19:39,860,729...39,881,019
Ensembl chr19:39,860,501...39,881,064 		JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase affects degradation ISO GNS affects the degradation of Keratan Sulfate CTD PMID:3391615 NCBI chr 7:56,889,139...56,923,170
Ensembl chr 7:56,889,232...56,923,151 		JBrowse link
Laurolactam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO laurolactam binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO laurolactam binds to and results in decreased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO laurolactam binds to and results in decreased activity of NR3C1 protein CTD PMID:27633901 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO laurolactam binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
peptidoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]] CTD PMID:19376148 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aqp1 aquaporin 1 decreases expression
multiple interactions		 ISO Peptidoglycan results in decreased expression of AQP1 mRNA; Peptidoglycan results in decreased expression of AQP1 protein
SB 203580 inhibits the reaction [Peptidoglycan results in decreased expression of AQP1 protein]		 CTD PMID:21647617 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO Peptidoglycan results in increased expression of BCL2A1 mRNA CTD PMID:15860229 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Peptidoglycan results in increased secretion of CCL2 protein CTD PMID:15593098 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Peptidoglycan results in increased expression of CCL20 mRNA; Peptidoglycan results in increased expression of CCL20 protein CTD PMID:15191912 PMID:15860229 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Clec7a C-type lectin domain containing 7A multiple interactions ISO CLEC7A protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4] CTD PMID:17030235 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases expression		 ISO CSF2 protein promotes the reaction [Peptidoglycan results in increased secretion of CXCL8 protein]
Peptidoglycan results in increased expression of CSF2 mRNA; Peptidoglycan results in increased expression of CSF2 protein		 CTD PMID:12176910 PMID:12574323 PMID:15191912 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases secretion ISO Peptidoglycan results in increased secretion of CXCL2 protein CTD PMID:15593098 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Defb5 defensin beta 5 increases expression ISO Peptidoglycan results in increased expression of DEFB4 mRNA; Peptidoglycan results in increased expression of DEFB4 protein CTD PMID:15893496 NCBI chr16:70,613,200...70,615,360
Ensembl chr16:70,613,146...70,615,467 		JBrowse link
G Ehd1 EH-domain containing 1 increases expression ISO Peptidoglycan results in increased expression of EHD1 mRNA CTD PMID:15860229 NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Peptidoglycan results in increased expression of GADD45B mRNA CTD PMID:15860229 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein; [Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; [Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Thiomalates results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]; Thiomalates promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein] CTD PMID:21355852 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Peptidoglycan results in increased expression of ICAM1 mRNA CTD PMID:15860229 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 increases expression
increases secretion
multiple interactions		 ISO Peptidoglycan results in increased expression of IL10 protein
Peptidoglycan results in increased secretion of IL10 protein
Sirolimus inhibits the reaction [Peptidoglycan results in increased expression of IL10 protein]
MYD88 gene mutant form inhibits the reaction [Peptidoglycan results in increased expression of IL10 protein]; Peptidoglycan results in increased expression of and results in increased secretion of IL10 protein
Peptidoglycan results in increased expression of IL10 mRNA		 CTD PMID:11169223 PMID:16224278 PMID:17238832 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B increases expression ISO Peptidoglycan results in increased expression of IL12B mRNA CTD PMID:15860229 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Peptidoglycan results in increased expression of IL1A mRNA CTD PMID:15860229 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Peptidoglycan results in increased expression of IL1B mRNA; Peptidoglycan results in increased expression of IL1B protein CTD PMID:12574323 PMID:15860229 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Peptidoglycan results in increased expression of IL23A mRNA CTD PMID:15860229 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO [Lipopolysaccharides co-treated with Peptidoglycan] results in increased secretion of IL6 protein
Peptidoglycan results in increased expression of IL6 mRNA		 CTD PMID:12185005 PMID:15860229 PMID:21355852 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Peptidoglycan results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Peptidoglycan results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19376148 PMID:21647617 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Peptidoglycan results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Peptidoglycan results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19376148 PMID:21647617 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Peptidoglycan results in increased phosphorylation of MAPK8 protein CTD PMID:21647617 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO Peptidoglycan results in increased expression of MMP1 mRNA CTD PMID:15860229 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions		 ISO Peptidoglycan results in increased expression of MYD88 protein
MYD88 gene mutant form inhibits the reaction [Peptidoglycan results in increased expression of IL10 protein]		 CTD PMID:15593098 PMID:17238832 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein] CTD PMID:19376148 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pla2g5 phospholipase A2, group V multiple interactions ISO PLA2G5 protein promotes the reaction [Peptidoglycan results in increased metabolism of Eicosanoids] CTD PMID:17369491 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [[Lipopolysaccharides co-treated with Peptidoglycan] co-treated with Thiomalates] results in increased expression of PRDX3 protein; [Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein] CTD PMID:21355852 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Peptidoglycan results in increased expression of PTGS2 mRNA CTD PMID:15860229 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Peptidoglycan affects the localization of RELA protein CTD PMID:15893496 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO Peptidoglycan results in increased expression of SESN2 mRNA CTD PMID:25637945 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Peptidoglycan results in increased expression of SOD2 mRNA CTD PMID:15860229 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO SYK protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4] CTD PMID:17030235 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
increases expression
affects response to substance		 ISO Peptidoglycan binds to and results in increased activity of TLR2 protein
Peptidoglycan results in increased expression of TLR2 mRNA; Peptidoglycan results in increased expression of TLR2 protein
TLR2 protein affects the susceptibility to Peptidoglycan
Peptidoglycan binds to and results in increased activity of TLR2 protein; TLR2 protein promotes the reaction [Peptidoglycan results in increased metabolism of Eicosanoids]		 CTD PMID:12734376 PMID:15593098 PMID:17369491 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Peptidoglycan results in increased expression of TNF mRNA; Peptidoglycan results in increased expression of TNF protein
Cannabidiol analog inhibits the reaction [Peptidoglycan results in increased expression of TNF protein]		 CTD PMID:11169223 PMID:15860229 PMID:15893496 PMID:30796934 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Peptidoglycan results in increased expression of TNFAIP6 mRNA CTD PMID:15860229 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO [Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of TXN2 protein; Thiomalates promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of TXN2 protein] CTD PMID:21355852 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
poly(N-acetyllactosamine) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chst5 carbohydrate sulfotransferase 5 increases sulfation ISO CHST6 protein results in increased sulfation of poly-N-acetyllactosamine
CHST5 protein results in increased sulfation of poly-N-acetyllactosamine		 CTD PMID:12218059 NCBI chr19:39,860,729...39,881,019
Ensembl chr19:39,860,501...39,881,064 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    chemical entity 19738
      atom 19738
        nonmetal atom 19678
          nitrogen atom 18877
            nitrogen molecular entity 18877
              organonitrogen compound 18712
                aminoglycan 399
                  Brucella sp. O-PS A-antigen 0
                  alpha-Gal glycan 0
                  chitin 6
                  chitosan 41
                  glycosaminoglycan + 373
                  poly(D-galactosamine) 0
                  poly(N-acetyllactosamine) 1
                  poly[(1->4)-N-acetyl-beta-D-glucosamyl]-(1->4)-N-acetyl-2-deoxy-2-amino-D-glucono-1,5-lactone 0
                  polysialic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            heteroorganic entity 19384
                              organochalcogen compound 19176
                                organooxygen compound 19095
                                  carbohydrates and carbohydrate derivatives 14423
                                    carbohydrate 14423
                                      polysaccharide 4852
                                        polysaccharide derivative 4834
                                          aminoglycan 399
                                            Brucella sp. O-PS A-antigen 0
                                            alpha-Gal glycan 0
                                            chitin 6
                                            chitosan 41
                                            glycosaminoglycan + 373
                                            poly(D-galactosamine) 0
                                            poly(N-acetyllactosamine) 1
                                            poly[(1->4)-N-acetyl-beta-D-glucosamyl]-(1->4)-N-acetyl-2-deoxy-2-amino-D-glucono-1,5-lactone 0
                                            polysialic acid + 0
paths to the root