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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ametryn
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Accession:CHEBI:22472 term browser browse the term
Definition:A methylthio-1,3,5-triazine that is 2-(methylsulfanyl)-1,3,5-triazine substituted by an ethylamino and an isopropylamino group at positions 4 and 6 respectively.
Synonyms:exact_synonym: N(2)-ethyl-N(4)-isopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine
 related_synonym: 2-ethylamino-4-isopropylamino-6-methylmercapto-s-triazine;   2-methylthio-4-ethylamino-6-isopropylamino-s-triazine;   Ametrex;   Evik;   Formula=C9H17N5S;   Gesapax;   InChI=1S/C9H17N5S/c1-5-10-7-12-8(11-6(2)3)14-9(13-7)15-4/h6H,5H2,1-4H3,(H2,10,11,12,13,14);   InChIKey=RQVYBGPQFYCBGX-UHFFFAOYSA-N;   N(2)-ethyl-6-(methylsulfanyl)-N(4)-(propan-2-yl)-1,3,5-triazine-2,4-diamine;   N-ethyl-6-(methylsulfanyl)-N'-(propan-2-yl)-1,3,5-triazine-2,4-diamine;   N-ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine;   N-ethyl-N'-(1-methylethyl)-6-(methylthio)-2,4-diaminetriazine;   N-ethyl-N'-isopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine;   SMILES=CCNc1nc(NC(C)C)nc(SC)n1;   ametryne
 xref: Beilstein:613099;   CAS:834-12-8;   KEGG:C18700
 xref_mesh: MESH:C100057
 xref: MetaCyc:CPD-9343;   PDBeChem:RYN;   PMID:21626650;   PMID:23566464;   PMID:24413480;   PMID:24579518;   PMID:24757962;   PPDB:27;   Pesticides:ametryn;   Reaxys:613099;   UM-BBD_compID:c0260


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ametryn term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 decreases expression EXP ametryne results in decreased expression of CDH1 mRNA CTD PMID:26310382 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 increases expression EXP ametryne results in increased expression of CDH2 mRNA CTD PMID:26310382 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
ISO POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] CTD PMID:8971136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP ametryne results in decreased expression of GJA1 mRNA CTD PMID:26310382 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP ametryne results in increased expression of GSTM1 mRNA CTD PMID:26310382 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] CTD PMID:8971136 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP ametryne results in increased expression of SOD2 mRNA CTD PMID:26310382 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      chemical role 19336
        environmental contaminant 18636
          ametryn 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        polyamine 8267
                                          diamine 8196
                                            diamino-1,3,5-triazine 3823
                                              ametryn 7
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