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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ametryn
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Accession:CHEBI:22472 term browser browse the term
Definition:A methylthio-1,3,5-triazine that is 2-(methylsulfanyl)-1,3,5-triazine substituted by an ethylamino and an isopropylamino group at positions 4 and 6 respectively.
Synonyms:exact_synonym: N(2)-ethyl-N(4)-isopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine
 related_synonym: 2-ethylamino-4-isopropylamino-6-methylmercapto-s-triazine;   2-methylthio-4-ethylamino-6-isopropylamino-s-triazine;   Ametrex;   Evik;   Formula=C9H17N5S;   Gesapax;   InChI=1S/C9H17N5S/c1-5-10-7-12-8(11-6(2)3)14-9(13-7)15-4/h6H,5H2,1-4H3,(H2,10,11,12,13,14);   InChIKey=RQVYBGPQFYCBGX-UHFFFAOYSA-N;   N(2)-ethyl-6-(methylsulfanyl)-N(4)-(propan-2-yl)-1,3,5-triazine-2,4-diamine;   N-ethyl-6-(methylsulfanyl)-N'-(propan-2-yl)-1,3,5-triazine-2,4-diamine;   N-ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine;   N-ethyl-N'-(1-methylethyl)-6-(methylthio)-2,4-diaminetriazine;   N-ethyl-N'-isopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine;   SMILES=CCNc1nc(NC(C)C)nc(SC)n1;   ametryne
 xref: Beilstein:613099;   CAS:834-12-8;   KEGG:C18700
 xref_mesh: MESH:C100057
 xref: MetaCyc:CPD-9343;   PDBeChem:RYN;   PMID:21626650;   PMID:23566464;   PMID:24413480;   PMID:24579518;   PMID:24757962;   PPDB:27;   Pesticides:ametryn;   Reaxys:613099;   UM-BBD_compID:c0260



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ametryn term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 decreases expression EXP ametryne results in decreased expression of CDH1 mRNA CTD PMID:26310382 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 increases expression EXP ametryne results in increased expression of CDH2 mRNA CTD PMID:26310382 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
ISO POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] CTD PMID:8971136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP ametryne results in decreased expression of GJA1 mRNA CTD PMID:26310382 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP ametryne results in increased expression of GSTM1 mRNA CTD PMID:26310382 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne] CTD PMID:8971136 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP ametryne results in increased expression of SOD2 mRNA CTD PMID:26310382 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19757
    role 19730
      chemical role 19370
        environmental contaminant 18759
          ametryn 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    main group molecular entity 19703
                      s-block molecular entity 19557
                        hydrogen molecular entity 19550
                          hydrides 19031
                            inorganic hydride 17955
                              pnictogen hydride 17940
                                nitrogen hydride 17836
                                  azane 17618
                                    ammonia 17617
                                      organic amino compound 17617
                                        polyamine 8327
                                          diamine 8255
                                            diamino-1,3,5-triazine 3828
                                              ametryn 7
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