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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein] |
CTD |
PMID:24448832 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcd1 |
ATP binding cassette subfamily D member 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD1 mRNA] |
CTD |
PMID:29065513 |
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NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115
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G |
Abcd3 |
ATP binding cassette subfamily D member 3 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD3 mRNA] |
CTD |
PMID:29065513 |
|
NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
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G |
Acat1 |
acetyl-CoA acetyltransferase 1 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [iron(II)-ascorbic acid complex results in decreased activity of ACAT1 protein] |
CTD |
PMID:10656290 |
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NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP ISO |
alpha-Tocopherol inhibits the reaction [Streptozocin results in increased activity of ACHE protein] [alpha-Tocopherol co-treated with Paraoxon] results in decreased activity of ACHE protein; ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein]; alpha-Tocopherol binds to and results in decreased activity of ACHE protein; alpha-Tocopherol promotes the reaction [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in decreased activity of ACHE protein] |
CTD |
PMID:19464315 PMID:34506764 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Acvrl1 |
activin A receptor like type 1 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of ACVRL1 mRNA |
CTD |
PMID:16908007 |
|
NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:17532611 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of AKR1B1 mRNA |
CTD |
PMID:16908007 |
|
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP ISO |
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased phosphorylation of and results in decreased activity of AKT1 protein] alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:19351882 PMID:22343715 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein] |
CTD |
PMID:7728901 |
|
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alas1 |
5'-aminolevulinate synthase 1 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein] |
CTD |
PMID:12180188 |
|
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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G |
Alb |
albumin |
multiple interactions |
EXP ISO |
alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]; sodium-4,5-dihydroxy-1,3-benzene disulfonate promotes the reaction [alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]] [alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of ALB protein; ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein] |
CTD |
PMID:17429802 PMID:34506764 PMID:36372912 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Ano6 |
anoctamin 6 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of ANO6 mRNA] |
CTD |
PMID:27886375 |
|
NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589
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G |
Apex2 |
apurinic/apyrimidinic endodeoxyribonuclease 2 |
multiple interactions decreases expression |
EXP |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA] alpha-Tocopherol results in decreased expression of APEX2 mRNA |
CTD |
PMID:26332274 |
|
NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439
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G |
Apoa1 |
apolipoprotein A1 |
decreases expression decreases activity |
ISO EXP |
alpha-Tocopherol results in decreased expression of APOA1 mRNA; alpha-Tocopherol results in decreased expression of APOA1 protein alpha-Tocopherol results in decreased activity of APOA1 promoter |
CTD |
PMID:16423621 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apob |
apolipoprotein B |
multiple interactions |
ISO |
alpha-Tocopherol promotes the reaction [APOB protein results in increased reduction of Copper] |
CTD |
PMID:11368321 |
|
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein] |
CTD |
PMID:12684028 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:14645110 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Bace1 |
beta-secretase 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA] |
CTD |
PMID:19196431 |
|
NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of BAD mRNA |
CTD |
PMID:26332274 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO EXP |
alpha-Tocopherol affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein] alpha-Tocopherol inhibits the reaction [Acrylamide results in increased expression of BAX protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein] alpha-Tocopherol results in increased expression of BAX mRNA |
CTD |
PMID:11805214 PMID:26332274 PMID:32134168 PMID:36058301 PMID:38242491 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bche |
butyrylcholinesterase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Endosulfan results in decreased activity of BCHE protein] |
CTD |
PMID:24299906 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO EXP |
alpha-Tocopherol affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; TNFRSF10B mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] alpha-Tocopherol analog results in decreased expression of BCL2 mRNA; alpha-Tocopherol analog results in decreased expression of BCL2 protein [alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein] |
CTD |
PMID:11805214 PMID:16005924 PMID:16135673 PMID:20686688 PMID:29297235 PMID:36058301 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression multiple interactions |
EXP |
alpha-Tocopherol results in decreased expression of BCL2L1 protein alpha-Tocopherol inhibits the reaction [Acrylamide results in decreased expression of BCL2L1 protein] |
CTD |
PMID:18942769 PMID:38242491 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein] |
CTD |
PMID:30776390 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Bpifb1 |
BPI fold containing family B, member 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of BPIFB1 protein |
CTD |
PMID:36372912 |
|
NCBI chr 3:142,672,995...142,706,258
Ensembl chr 3:142,672,995...142,706,256
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G |
Canx |
calnexin |
affects localization increases expression |
EXP |
alpha-Tocopherol affects the localization of CANX protein alpha-Tocopherol results in increased expression of CANX mRNA; alpha-Tocopherol results in increased expression of CANX protein |
CTD |
PMID:16908007 |
|
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Casp3 |
caspase 3 |
multiple interactions decreases activity |
ISO EXP |
[alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein; [alpha-Tocopherol co-treated with Tretinoin] results in increased activity of CASP3 protein; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased cleavage of and results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Vitamin A results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP3 protein [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein] [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 protein] alpha-Tocopherol results in decreased activity of CASP3 protein |
CTD |
PMID:12450566 PMID:14599462 PMID:14722101 PMID:15095415 PMID:17618090 PMID:17874176 PMID:17936189 PMID:21869839 PMID:22389237 PMID:23042730 PMID:29065513 PMID:29129777 PMID:30776390 PMID:31712109 PMID:32134168 PMID:36058301 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]] |
CTD |
PMID:23042730 PMID:29129777 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
alpha-Tocopherol analog results in increased cleavage of CASP8 protein |
CTD |
PMID:20686688 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions |
ISO EXP |
alpha-Tocopherol analog results in increased cleavage of CASP9 protein alpha-Tocopherol inhibits the reaction [Acrylamide results in increased expression of CASP9 protein] alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein] alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:20686688 PMID:21869839 PMID:31712109 PMID:36058301 PMID:38242491 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases activity increases expression |
EXP ISO |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; [Curcumin co-treated with alpha-Tocopherol] inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Sodium Selenite co-treated with alpha-Tocopherol] inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [Copper Sulfate results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [flubendiamide results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Camptothecin results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Streptozocin results in decreased expression of CAT protein] alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA] alpha-Tocopherol results in increased activity of CAT protein alpha-Tocopherol results in increased expression of CAT protein alpha-Tocopherol results in increased expression of CAT mRNA; alpha-Tocopherol results in increased expression of CAT protein |
CTD |
PMID:9306888 PMID:16979807 PMID:18547560 PMID:19083475 PMID:19464315 PMID:19941068 PMID:20194575 PMID:21322096 PMID:22732938 PMID:25233897 PMID:25304969 PMID:26365763 PMID:27823922 PMID:30057697 PMID:31022331 PMID:36058301 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA] |
CTD |
PMID:27257344 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein] alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] |
CTD |
PMID:19735175 PMID:24333275 PMID:26332274 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA] |
CTD |
PMID:26332274 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA] |
CTD |
PMID:26332274 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Cd36 |
CD36 molecule |
affects expression multiple interactions |
EXP |
alpha-Tocopherol affects the expression of CD36 mRNA alpha-Tocopherol inhibits the reaction [[troglitazone co-treated with Ethanol] results in increased expression of CD36 protein] |
CTD |
PMID:16407258 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions decreases expression |
EXP |
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA] alpha-Tocopherol results in decreased expression of CDKN1A mRNA |
CTD |
PMID:26332274 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Cadmium results in decreased expression of CFTR protein] |
CTD |
PMID:20363832 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein; Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein] |
CTD |
PMID:25891525 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Clcn3 |
chloride voltage-gated channel 3 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of CLCN3 mRNA] |
CTD |
PMID:27886375 |
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NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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G |
Cldn2 |
claudin 2 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Potassium Dichromate affects the localization of CLDN2 protein] |
CTD |
PMID:19766176 |
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NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions increases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CPT1A mRNA]; alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA] alpha-Tocopherol results in increased expression of CPT1A mRNA |
CTD |
PMID:17936189 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Crabp2 |
cellular retinoic acid binding protein 2 |
multiple interactions |
ISO |
[Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 mRNA; [Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 protein |
CTD |
PMID:15225641 |
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NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:30776390 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crp |
C-reactive protein |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein |
CTD |
PMID:18191645 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cryaa |
crystallin, alpha A |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of CRYAA mRNA |
CTD |
PMID:16908007 |
|
NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349
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G |
Ctsd |
cathepsin D |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of CTSD protein |
CTD |
PMID:18942769 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA] |
CTD |
PMID:24333275 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] |
CTD |
PMID:24333275 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]] |
CTD |
PMID:29284473 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
EXP |
alpha-Tocopherol results in increased expression of CYP1A1 mRNA [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]; alpha-Tocopherol results in increased expression of and results in increased activity of CYP1A1 protein |
CTD |
PMID:15665910 PMID:22389237 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity multiple interactions |
EXP ISO |
alpha-Tocopherol results in increased activity of CYP1A2 protein alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:15665910 PMID:26102010 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases expression |
ISO |
alpha-Tocopherol results in decreased expression of CYP2B10 mRNA |
CTD |
PMID:26102010 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] |
CTD |
PMID:26102010 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression multiple interactions |
EXP ISO |
alpha-Tocopherol results in increased expression of CYP2E1 mRNA [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA] |
CTD |
PMID:26332274 PMID:27919644 PMID:28062356 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases expression |
EXP ISO |
[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] alpha-Tocopherol results in increased expression of CYP3A4 mRNA alpha-Tocopherol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CYP3A4 mRNA]; Galactosamine inhibits the reaction [alpha-Tocopherol results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:17936189 PMID:27919644 PMID:31102695 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases expression multiple interactions |
ISO |
alpha-Tocopherol results in increased expression of CYP3A13 mRNA; alpha-Tocopherol results in increased expression of CYP3A13 protein alpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone] |
CTD |
PMID:26102010 PMID:31102695 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
EXP ISO |
alpha-Tocopherol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] alpha-Tocopherol analog results in increased expression of DDIT3 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein] |
CTD |
PMID:20459685 PMID:20686688 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
affects localization |
ISO |
alpha-Tocopherol affects the localization of DIABLO protein |
CTD |
PMID:15582575 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases phosphorylation multiple interactions |
ISO |
alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:20686688 |
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NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] |
CTD |
PMID:22389237 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] |
CTD |
PMID:22389237 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Faslg |
Fas ligand |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of FASLG mRNA |
CTD |
PMID:26332274 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fbl |
fibrillarin |
decreases expression |
EXP |
alpha-Tocopherol deficiency results in decreased expression of FBL protein |
CTD |
PMID:15247049 |
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NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of FMO1 mRNA |
CTD |
PMID:16908007 |
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NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein] |
CTD |
PMID:9225831 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] |
CTD |
PMID:14572611 |
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NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of GADD45A mRNA |
CTD |
PMID:26332274 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA |
CTD |
PMID:24530478 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
EXP ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLM mRNA |
CTD |
PMID:22389237 PMID:24530478 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gfap |
glial fibrillary acidic protein |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of GFAP protein |
CTD |
PMID:18942769 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gnai2 |
G protein subunit alpha i2 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI2 protein] |
CTD |
PMID:18441196 |
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NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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G |
Gnai3 |
G protein subunit alpha i3 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI3 protein] |
CTD |
PMID:18441196 |
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NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [beryllium nitrate results in increased activity of GPT protein] |
CTD |
PMID:17429802 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of GPX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA] [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ovalbumin promotes the reaction [Ozone results in increased activity of GPX1 protein]] |
CTD |
PMID:26365763 PMID:29284473 PMID:36058301 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] |
CTD |
PMID:14642406 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Camptothecin results in decreased activity of GSR protein]; alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GSR protein] |
CTD |
PMID:16979807 PMID:25304969 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstt1 |
glutathione S-transferase theta 1 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of GSTT1 protein |
CTD |
PMID:9855024 |
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NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Gusb |
glucuronidase, beta |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] |
CTD |
PMID:19135433 |
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NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
Hal |
histidine ammonia lyase |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of HAL mRNA |
CTD |
PMID:16908007 |
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NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] |
CTD |
PMID:19595682 PMID:21535577 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
affects expression multiple interactions |
ISO EXP |
alpha-Tocopherol affects the expression of HMOX1 mRNA [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of HMOX1 protein] alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein] |
CTD |
PMID:8743975 PMID:12180188 PMID:22053912 PMID:22389237 PMID:36058301 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hp |
haptoglobin |
affects activity multiple interactions |
ISO |
alpha-Tocopherol affects the activity of HP protein polymorphism Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism] |
CTD |
PMID:19769483 |
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NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of HSD17B3 mRNA] |
CTD |
PMID:32134168 |
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NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of HSD3B2 mRNA] |
CTD |
PMID:32134168 |
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NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of HSPA1B mRNA |
CTD |
PMID:16908007 |
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NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein] |
CTD |
PMID:22313677 PMID:25551565 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
EXP ISO |
[alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IFNG mRNA; alpha-Tocopherol results in decreased susceptibility to [IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]] |
CTD |
PMID:16307444 PMID:24333275 PMID:29284473 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA |
CTD |
PMID:23859036 |
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NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:34310962 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO EXP |
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein] [alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IL10 mRNA |
CTD |
PMID:24333275 PMID:25551565 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]] |
CTD |
PMID:29284473 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A mRNA]] |
CTD |
PMID:29284473 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein] |
CTD |
PMID:15025948 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of IL1B mRNA] alpha-Tocopherol inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA] |
CTD |
PMID:19135433 PMID:19735175 PMID:26332274 PMID:31712109 PMID:38242491 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL5 mRNA]] |
CTD |
PMID:29284473 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
alpha-Tocopherol inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of IL6 protein] alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of IL6 protein] alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL6 protein]] |
CTD |
PMID:15630180 PMID:24296301 PMID:29284473 PMID:32134168 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein |
CTD |
PMID:12949374 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of JUN protein] alpha-Tocopherol results in increased expression of JUN mRNA; alpha-Tocopherol results in increased expression of JUN protein |
CTD |
PMID:14645110 PMID:19000923 PMID:20025956 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased activity of KCNH2 protein] |
CTD |
PMID:12531891 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] |
CTD |
PMID:36058301 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in decreased activity of LCAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] |
CTD |
PMID:19595682 PMID:21535577 |
|
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] |
CTD |
PMID:14572611 |
|
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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|
G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
EXP ISO |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHA protein] [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased secretion of LDHA protein] |
CTD |
PMID:21322096 PMID:26270818 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Ldhb |
lactate dehydrogenase B |
multiple interactions |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] |
CTD |
PMID:21322096 |
|
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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G |
Lgals3bp |
galectin 3 binding protein |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of LGALS3BP protein |
CTD |
PMID:36372912 |
|
NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] |
CTD |
PMID:14572611 |
|
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions affects activity |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK1 protein] [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK1 protein] [alpha-Tocopherol affects the activity of MAPK1 protein] which results in decreased susceptibility to Potassium Dichromate |
CTD |
PMID:17011908 PMID:19766176 PMID:30776390 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK14 protein] alpha-Tocopherol inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:12684028 PMID:14645110 PMID:29284473 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions affects activity |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK3 protein] [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK3 protein] [alpha-Tocopherol affects the activity of MAPK3 protein] which results in decreased susceptibility to Potassium Dichromate |
CTD |
PMID:14645110 PMID:17011908 PMID:19766176 PMID:30776390 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:12684028 PMID:14645110 PMID:20686688 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation multiple interactions |
ISO |
alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:20686688 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mb |
myoglobin |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride] |
CTD |
PMID:17478120 |
|
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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G |
Mbp |
myelin basic protein |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein] |
CTD |
PMID:14645110 |
|
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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G |
Mgat3 |
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of MGAT3 mRNA |
CTD |
PMID:16908007 |
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NCBI chr 7:111,708,353...111,761,825
Ensembl chr 7:111,675,730...111,762,026
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA |
CTD |
PMID:23859036 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] |
CTD |
PMID:31022331 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Muc4 |
mucin 4, cell surface associated |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of MUC4 protein |
CTD |
PMID:36372912 |
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NCBI chr11:68,008,245...68,053,242
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA] |
CTD |
PMID:24333275 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein] |
CTD |
PMID:16005924 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nefh |
neurofilament heavy chain |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of NEFH protein modified form |
CTD |
PMID:18942769 |
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NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]; [alpha-Tocopherol co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; alpha-Tocopherol inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 mRNA]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of NFE2L2 protein] [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] promotes the reaction [[Ozone co-treated with Oxygen] results in increased localization of NFE2L2 protein]; alpha-Tocopherol promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein] |
CTD |
PMID:22389237 PMID:26270818 PMID:29297235 PMID:31412289 PMID:32134168 PMID:36058301 More...
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions increases activity |
EXP ISO |
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]] alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]] alpha-Tocopherol results in increased activity of NFKB1 protein |
CTD |
PMID:15025948 PMID:16135673 PMID:17936189 PMID:19083475 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO EXP |
alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; alpha-Tocopherol inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein] [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] alpha-Tocopherol inhibits the reaction [Acrylamide results in increased phosphorylation of NFKBIA protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:16135673 PMID:17532611 PMID:25551565 PMID:38242491 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein] alpha-Tocopherol inhibits the reaction [Galactosamine results in increased expression of NOS2 mRNA] |
CTD |
PMID:17936189 PMID:19135433 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of NOS3 mRNA; alpha-Tocopherol results in increased expression of NOS3 protein |
CTD |
PMID:16949522 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP ISO |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein] |
CTD |
PMID:22389237 PMID:36058301 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA] |
CTD |
PMID:17936189 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Ogdh |
oxoglutarate dehydrogenase |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [sodium arsenite results in decreased activity of OGDH protein] |
CTD |
PMID:12915223 |
|
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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G |
Orm1 |
orosomucoid 1 |
increases expression |
ISO |
alpha-Tocopherol results in increased expression of ORM1 mRNA; alpha-Tocopherol results in increased expression of ORM1 protein |
CTD |
PMID:19000923 PMID:20025956 |
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NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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G |
Park7 |
Parkinsonism associated deglycase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein] |
CTD |
PMID:16439141 |
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NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO EXP |
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein] alpha-Tocopherol inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein] |
CTD |
PMID:14645110 PMID:24448832 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pawr |
pro-apoptotic WT1 regulator |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein] |
CTD |
PMID:10428045 |
|
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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G |
Pax3 |
paired box 3 |
multiple interactions increases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA] alpha-Tocopherol results in increased expression of PAX3 mRNA |
CTD |
PMID:12739027 |
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NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
decreases expression |
EXP |
alpha-Tocopherol results in decreased expression of PCK1 mRNA |
CTD |
PMID:11597575 |
|
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] |
CTD |
PMID:22389237 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein |
CTD |
PMID:23859036 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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G |
Pgk1 |
phosphoglycerate kinase 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] |
CTD |
PMID:18603805 |
|
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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G |
Plg |
plasminogen |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]; alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein] |
CTD |
PMID:11419606 |
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NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
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G |
Pltp |
phospholipid transfer protein |
decreases abundance |
ISO |
PLTP mutant form results in decreased abundance of alpha-Tocopherol |
CTD |
PMID:16675720 |
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NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions increases expression |
ISO |
alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of PPARA mRNA] alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA] alpha-Tocopherol results in increased expression of PPARA mRNA |
CTD |
PMID:17936189 PMID:29065513 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression multiple interactions increases activity |
ISO EXP |
alpha-Tocopherol results in increased expression of PPARG mRNA; alpha-Tocopherol results in increased expression of PPARG protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein] alpha-Tocopherol results in increased activity of PPARG protein |
CTD |
PMID:11752099 PMID:14521714 PMID:19083475 PMID:22389237 PMID:28062356 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppia |
peptidylprolyl isomerase A |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of PPIA mRNA |
CTD |
PMID:16908007 |
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NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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G |
Psmc6 |
proteasome 26S subunit, ATPase 6 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein] |
CTD |
PMID:17532611 |
|
NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases activity multiple interactions |
ISO EXP |
alpha-Tocopherol metabolite results in decreased activity of PTGS2 protein; alpha-Tocopherol results in decreased activity of PTGS2 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein] |
CTD |
PMID:15225597 PMID:22389237 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization multiple interactions |
ISO EXP |
alpha-Tocopherol affects the localization of RELA protein [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased localization of RELA protein]; alpha-Tocopherol affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]] alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:15025948 PMID:16135673 PMID:16882165 PMID:17936189 PMID:26270818 PMID:34310962 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6 |
ribosomal protein S6 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein] |
CTD |
PMID:22343715 |
|
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
[Tretinoin co-treated with alpha-Tocopherol co-treated with Okadaic Acid] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with alpha-Tocopherol] results in decreased phosphorylation of RXRA protein |
CTD |
PMID:15225641 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Sele |
selectin E |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of SELE protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA] |
CTD |
PMID:12566129 PMID:25551565 |
|
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Slc1a2 |
solute carrier family 1 member 2 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein] |
CTD |
PMID:34310962 |
|
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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G |
Slc7a11 |
solute carrier family 7 member 11 |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA; [alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 protein |
CTD |
PMID:24530478 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of SLPI protein |
CTD |
PMID:36372912 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Smad4 |
SMAD family member 4 |
multiple interactions |
ISO |
SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol] |
CTD |
PMID:20562578 |
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NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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G |
Snca |
synuclein alpha |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:16439141 |
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NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases expression |
EXP ISO |
[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of SOD1 protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein] alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of SOD1 protein] alpha-Tocopherol results in increased expression of SOD1 mRNA; alpha-Tocopherol results in increased expression of SOD1 protein |
CTD |
PMID:19083475 PMID:20194575 PMID:21344382 PMID:22732938 PMID:26365763 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression increases expression multiple interactions |
EXP |
alpha-Tocopherol results in decreased expression of SOD2 protein alpha-Tocopherol results in increased expression of SOD2 mRNA; alpha-Tocopherol results in increased expression of SOD2 protein [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein] |
CTD |
PMID:16135673 PMID:18942769 PMID:20194575 PMID:22732938 PMID:23859036 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Srsf2 |
serine and arginine rich splicing factor 2 |
decreases expression |
EXP |
alpha-Tocopherol deficiency results in decreased expression of SRSF2 protein |
CTD |
PMID:15247049 |
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NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
EXP |
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of STAR mRNA] |
CTD |
PMID:32134168 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stat3 |
signal transducer and activator of transcription 3 |
increases expression |
EXP |
alpha-Tocopherol results in increased expression of STAT3 mRNA |
CTD |
PMID:16908007 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tert |
telomerase reverse transcriptase |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased activity of TERT protein] |
CTD |
PMID:20112180 |
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NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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G |
Tf |
transferrin |
multiple interactions |
ISO |
[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF protein |
CTD |
PMID:36372912 |
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tgfa |
transforming growth factor alpha |
decreases response to substance |
EXP |
alpha-Tocopherol results in decreased susceptibility to TGFA protein |
CTD |
PMID:7593635 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression |
EXP |
alpha-Tocopherol inhibits the reaction [Acrylamide results in increased expression of TGFB1 protein]; alpha-Tocopherol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species] alpha-Tocopherol results in decreased expression of TGFB1 mRNA |
CTD |
PMID:9608545 PMID:14732287 PMID:38242491 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein; alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein] |
CTD |
PMID:15790535 PMID:25891525 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tnf |
tumor necrosis factor |
multiple interactions affects expression decreases response to substance decreases expression |
ISO EXP |
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein] alpha-Tocopherol inhibits the reaction [Acrylamide results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein] alpha-Tocopherol affects the expression of TNF protein alpha-Tocopherol results in decreased susceptibility to TNF protein [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of TNF mRNA]]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of TNF mRNA] alpha-Tocopherol results in decreased expression of TNF protein |
CTD |
PMID:10588948 PMID:11805214 PMID:12195823 PMID:15025948 PMID:15630180 PMID:16135673 PMID:16750838 PMID:18191645 PMID:19135038 PMID:19135433 PMID:19735175 PMID:23042730 PMID:25551565 PMID:26332274 PMID:29284473 PMID:30776390 PMID:31712109 PMID:32134168 PMID:34310962 PMID:38242491 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 mRNA]; alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 protein] |
CTD |
PMID:12126965 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of TXN1 protein] |
CTD |
PMID:21344382 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] |
CTD |
PMID:22389237 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of VCAM1 protein]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein] |
CTD |
PMID:12566129 PMID:22313677 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
alpha-Tocopherol analog results in increased expression of XBP1 mRNA |
CTD |
PMID:20686688 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Xrcc6 |
X-ray repair cross complementing 6 |
multiple interactions |
EXP |
alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA] |
CTD |
PMID:26332274 |
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NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
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G |
Yy1 |
YY1 transcription factor |
multiple interactions |
ISO |
alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein] |
CTD |
PMID:34310962 |
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NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
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