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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:22450 term browser browse the term
Definition:An alpha-cyclopiazonic acid that has formula C20H20N2O3.
Synonyms:related_synonym: Formula=C20H20N2O3;   InChI=1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,24H,7H2,1-3H3/t12-,16+,17+/m1/s1;   InChIKey=SZINUGQCTHLQAZ-DQYPLSBCSA-N;   SMILES=[H][C@@]12N(C(=O)C(C(C)=O)=C1O)C(C)(C)[C@]1([H])Cc3cccc4[nH]cc(c34)[C@]21[H];   alpha-Cyclopiazonic acid;   cyclopiazonic acid
 xref: Beilstein:707309;   CAS:18172-33-3;   KEGG:C03032
 xref_mesh: MESH:C000543
 cyclic_relationship: is_tautomer_of CHEBI:17734

show annotations for term's descendants           Sort by:
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO cyclopiazonic acid inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] CTD PMID:12530016 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO cyclopiazonic acid inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] CTD PMID:11804840 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit affects response to substance EXP JUNB mRNA affects the susceptibility to cyclopiazonic acid CTD PMID:18716665 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO cyclopiazonic acid results in increased cleavage of SPTAN1 protein CTD PMID:21516125 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP cyclopiazonic acid results in increased expression of STAR protein CTD PMID:22001352 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tp73 tumor protein p73 increases degradation ISO cyclopiazonic acid results in increased degradation of TP73 protein modified form CTD PMID:21516125 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        poison 18120
          toxin 14321
            mycotoxin 12234
              cyclopiazonic acid 6
                alpha-cyclopiazonic acids 6
                  (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  organic heteropolycyclic compound 17977
                                    organic heterobicyclic compound 16784
                                      benzopyrrole 9547
                                        indoles 9215
                                          cyclopiazonic acid 6
                                            alpha-cyclopiazonic acids 6
                                              (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one 6
paths to the root