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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-N-substituted L-arginine
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Accession:CHEBI:22440 term browser browse the term
Definition:An L-arginine derivative that is L-arginine in which one of the hydrogens attached to the alpha-nitrogen has replaced by another atom or group.
Synonyms:related_synonym: Formula=C6H13N4O2R;   SMILES=NC(=N)NCCC[C@H](N[*])C(O)=O;   alpha-N-substituted L-arginines
 alt_id: CHEBI:10318
 xref: KEGG:C04026

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argatroban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein] CTD PMID:22841818 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA] CTD PMID:22841818 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein] CTD PMID:22841818 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA] CTD PMID:22841818 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of COL1A1 mRNA] CTD PMID:22841818 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO argatroban affects the reaction [Dietary Fats results in increased expression of CXCL2 mRNA] CTD PMID:22841818 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G F2 coagulation factor II multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of F2 protein]
argatroban binds to and results in decreased activity of F2 protein		 CTD PMID:15080313 PMID:16084352 PMID:18449412 PMID:22841818 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ICAM1 mRNA] CTD PMID:22841818 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]; argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides] CTD PMID:22841818 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of TIMP1 mRNA] CTD PMID:22841818 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        indicator 8675
          biomarker 6443
            L-arginine 51
              L-arginine derivative 44
                alpha-N-substituted L-arginine 10
                  N(2)-(2-carboxyethyl)-L-arginine 0
                  argatroban 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        amino acid 14113
                                          alpha-amino acid 11600
                                            L-alpha-amino acid 11432
                                              glutamine family amino acid 10259
                                                L-arginine 51
                                                  L-arginine derivative 44
                                                    alpha-N-substituted L-arginine 10
                                                      N(2)-(2-carboxyethyl)-L-arginine 0
                                                      argatroban 10
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