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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(+)-artemisinin
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Accession:CHEBI:223316 term browser browse the term
Definition:A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.
Synonyms:exact_synonym: (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one
 related_synonym: 1,5,9-trimethyl-(1R,4S,5R,9R,12S,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one;   Formula=C15H22O5;   InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1;   InChIKey=BLUAFEHZUWYNDE-NNWCWBAJSA-N;   Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one;   QHS;   Qing Hau Sau;   Qinghaosu;   Quing Hau Sau;   SMILES=C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4;   arteannuin;   artemisinina;   artemisinine;   artemisininum;   huanghuahaosu
 alt_id: CHEBI:8718
 xref: Beilstein:4194670;   CAS:63968-64-9;   Drug_Central:3871;   Gmelin:1755493;   KEGG:C09538;   KEGG:D02481;   KNApSAcK:C00003359;   LINCS:LSM-6546;   LIPID_MAPS_instance:LMPR0103190003
 xref_mesh: MESH:C031327
 xref: MetaCyc:CPD-7561;   PMID:15330155;   PMID:18008167;   PMID:19090980;   PMID:22174561;   PMID:7877142;   PMID:8544181;   Reaxys:4194670;   Wikipedia:Artemisinin


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(+)-artemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases activity
ISO artemisinine results in increased expression of ABCB1 mRNA
artemisinine results in decreased activity of ABCB1 protein
CTD PMID:15761118 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Casp3 caspase 3 increases activity EXP artemisinine results in increased activity of CASP3 protein CTD PMID:17948936 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression
ISO
EXP
artemisinine results in decreased activity of CYP1A2 protein
artemisinine results in increased expression of CYP1A2 mRNA
CTD PMID:11124226 PMID:16919048 PMID:17962186 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
increases expression
ISO artemisinine results in increased activity of CYP2A5 protein
artemisinine results in increased expression of CYP2A5 mRNA
CTD PMID:16919048 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
increases activity
EXP
ISO
artemisinine results in increased expression of CYP2B1 mRNA
artemisinine results in increased expression of CYP2B10 mRNA
artemisinine results in increased activity of CYP2B10 protein
CTD PMID:16919048 PMID:17962186 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
affects metabolic processing
increases expression
ISO [artemisinine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
CYP2B6 protein affects the metabolism of artemisinine
artemisinine results in increased expression of CYP2B6 mRNA
CTD PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO artemisinine results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO artemisinine results in increased expression of CYP2E1 mRNA CTD PMID:17962186 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases expression
ISO [artemisinine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of artemisinine
artemisinine results in increased expression of CYP3A4 mRNA
CTD PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO artemisinine inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; artemisinine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO artemisinine results in decreased activity of GSTA1 protein CTD PMID:11807801 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO artemisinine results in decreased activity of GSTP1 protein CTD PMID:11807801 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO artemisinine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinine co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein] CTD PMID:18463201 PMID:23355332 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO artemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein] CTD PMID:18463201 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [artemisinine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; artemisinine binds to and results in increased activity of NR1I2 protein CTD PMID:15761118 PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
affects expression
affects localization
increases activity
ISO
EXP
[artemisinine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; artemisinine binds to and results in increased activity of NR1I3 protein; artemisinine binds to and results in increased activity of NR1I3 protein mutant form
artemisinine binds to and results in increased activity of NR1I3 protein; fenvalerate inhibits the reaction [artemisinine binds to and results in increased activity of NR1I3 protein]
artemisinine results in increased expression of NR1I3 mRNA
artemisinine affects the expression of NR1I3 mRNA alternative form
artemisinine affects the localization of NR1I3 protein
artemisinine results in increased activity of NR1I3 protein; artemisinine results in increased activity of NR1I3 protein alternative form; artemisinine results in increased activity of NR1I3 protein mutant form
artemisinine results in increased activity of NR1I3 protein; artemisinine results in increased activity of NR1I3 protein mutant form
CTD PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 PMID:20686338 More... NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO artemisinine inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO artemisinine inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of RELA protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinine inhibits the reaction [Simvastatin results in increased localization of RELA protein] CTD PMID:18463201 PMID:23355332 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO artemisinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO artemisinine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO artemisinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] CTD PMID:27504015 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Tp53 tumor protein p53 increases activity ISO artemisinine results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
artemether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA CTD PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression
multiple interactions
ISO artemether affects the expression of NR1I3 mRNA alternative form
[Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; Artemether binds to and results in increased activity of NR1I3 protein alternative form
CTD PMID:24721719 PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
artemotil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression ISO artemotil affects the expression of NR1I3 mRNA alternative form CTD PMID:24721719 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:30551460 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression
decreases response to substance
ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate
CTD PMID:19513562 PMID:20144594 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Des desmin multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD PMID:30551460 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Flna filamin A increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD PMID:30551460 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD PMID:30551460 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance
ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate
CTD PMID:15796179 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases activity
multiple interactions
ISO Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD PMID:30551460 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 affects response to substance ISO GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD PMID:29031619 PMID:30551460 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naca nascent polypeptide associated complex subunit alpha decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD PMID:30551460 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD PMID:24704559 PMID:33002460 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:977,885...978,965 JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:3,217,184...3,220,192 JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
JBrowse link
G Rps15a ribosomal protein S15a decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Slc25a19 solute carrier family 25 member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD PMID:30551460 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Artesunate results in increased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD PMID:30551460 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:33259807 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions
ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:15878303 PMID:33259807 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
multiple interactions
ISO Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD PMID:33002460 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747
JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        inorganic group 19265
          peroxy group 3278
            peroxides 3278
              organic peroxide 105
                (+)-artemisinin 98
                  artemisinin derivative + 77
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic ester 15889
                                        lactone 11245
                                          terpene lactone 1786
                                            sesquiterpene lactone 1633
                                              (+)-artemisinin 98
                                                artemisinin derivative + 77
paths to the root