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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monoethylglycinexylidide
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Accession:CHEBI:222828 term browser browse the term
Definition:Amino acid amide formed from 2,6-dimethylaniline and N-ethylglycine components; an active metabolite of lidocaine, formed by oxidative deethylation. Used as an indicator of hepatic function.
Synonyms:exact_synonym: N-(2,6-dimethylphenyl)-N(2)-ethylglycinamide
 related_synonym: 2-Ethylamino-2',6'-acetoxylidide;   2-Ethylamino-2,6-acetoxylidine;   Ethylglycylxylidide;   Formula=C12H18N2O;   InChI=1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15);   InChIKey=WRMRXPASUROZGT-UHFFFAOYSA-N;   Lidocaine N-de-ethylated metabolite;   N-(2,6-Dimethylphenyl)-2-(ethylamino)acetamide;   N-Ethylglycinexylidide;   SMILES=CCNCC(=O)Nc1c(C)cccc1C;   norlidocaine;   omega-(ethylamino)-2',6'-dimethylacetanilide
 xref: Beilstein:2417108;   CAS:7728-40-7;   HMDB:HMDB0060656;   KEGG:C16561
 xref_mesh: MESH:C001173
 xref: PMID:17296334;   PMID:22212047;   PMID:22452841;   PMID:22468031;   PMID:7071904;   PMID:9989796;   Reaxys:2417108


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monoethylglycinexylidide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D increases hydrolysis EXP CES1D protein results in increased hydrolysis of monoethylglycinexylidide CTD PMID:12019189 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
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G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects chemical synthesis ISO CYP3A4 protein affects the chemical synthesis of monoethylglycinexylidide CTD PMID:15887009 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            xenobiotic metabolite 14244
              human xenobiotic metabolite 13576
                drug metabolite 4420
                  monoethylglycinexylidide 2
                    monoethylglycinexylidide hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                amino acid amide 891
                                                  monoethylglycinexylidide 2
                                                    monoethylglycinexylidide hydrochloride 0
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