adenosines - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	adenosines	go back to main search page
Accession:	CHEBI:22260	browse the term
Definition:	Any purine ribonucleoside that is a derivative of adenosine.

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Rat (765) Mouse (764) Human (782) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (6) Green Monkey (0) Naked Mole-rat (0) All
Genes (765)

2',3'-dideoxyadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]

PMID:25813982 PMID:31300867

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

epidermal growth factor

multiple interactions

Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects activity

Puromycin Aminonucleoside affects the activity of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

aminocarboxymuconate semialdehyde decarboxylase

decreases activity

Puromycin Aminonucleoside results in decreased activity of ACMSD protein

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

actin, beta

decreases expression

Puromycin Aminonucleoside results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, gamma 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of ACTG1 protein

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

actin related protein 2

increases expression

Puromycin Aminonucleoside results in increased expression of ACTR2 mRNA; Puromycin Aminonucleoside results in increased expression of ACTR2 protein

NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524

G

actin related protein 3

increases expression

Puromycin Aminonucleoside results in increased expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

angiotensinogen

affects expression
decreases expression
increases expression
multiple interactions

Puromycin Aminonucleoside affects the expression of AGT protein
Puromycin Aminonucleoside results in decreased expression of AGT protein
Puromycin Aminonucleoside results in increased expression of AGT mRNA
[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGT mRNA

PMID:2236972 PMID:8446257 PMID:12495295

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 2

multiple interactions
increases expression

[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGTR2 mRNA
Puromycin Aminonucleoside results in increased expression of AGTR2 mRNA

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

alanine-glyoxylate aminotransferase 2

increases expression

Puromycin Aminonucleoside results in increased expression of AGXT2 protein

NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
affects localization

Dexamethasone inhibits the reaction [Puromycin Aminonucleoside affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

albumin

affects transport
increases secretion
increases expression
affects localization
decreases expression

Puromycin Aminonucleoside affects the transport of ALB protein
Puromycin Aminonucleoside results in increased secretion of ALB protein
Puromycin Aminonucleoside results in increased expression of ALB mRNA; Puromycin Aminonucleoside results in increased expression of ALB protein
Puromycin Aminonucleoside affects the localization of ALB protein
Puromycin Aminonucleoside results in decreased expression of ALB protein

PMID:1453496 PMID:3301049 PMID:8413769 PMID:15798086 PMID:19264907 More...

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A2

increases expression

Puromycin Aminonucleoside results in increased expression of ALDH1A2 mRNA

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

angiopoietin 1

increases expression

Puromycin Aminonucleoside results in increased expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of APEX1 protein]

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

decreases response to substance
increases expression

APOA1 protein results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased expression of APOA1 mRNA; Puromycin Aminonucleoside results in increased expression of APOA1 protein

PMID:7066357 PMID:7442475 PMID:7595070 PMID:8412754 PMID:8413767 More...

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A2

increases expression

Puromycin Aminonucleoside results in increased expression of APOA2 protein

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein A4

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of APOA4 protein
Puromycin Aminonucleoside results in increased expression of APOA4 mRNA; Puromycin Aminonucleoside results in increased expression of APOA4 protein

PMID:7442475 PMID:8412754

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein B

increases expression

Puromycin Aminonucleoside results in increased expression of APOB protein

PMID:2725289 PMID:7442475 PMID:8506949

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein E

decreases response to substance
increases expression
affects expression

APOE protein results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased expression of APOE protein
Puromycin Aminonucleoside affects the expression of APOE mRNA

PMID:7442475 PMID:8413767 PMID:12472773

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

aquaporin 2

decreases expression

Puromycin Aminonucleoside results in decreased expression of AQP2 protein

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

aquaporin 3 (Gill blood group)

decreases expression

Puromycin Aminonucleoside results in decreased expression of AQP3 protein

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

activity-regulated cytoskeleton-associated protein

increases expression

Puromycin Aminonucleoside results in increased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of ATP1A1 protein
Puromycin Aminonucleoside results in increased expression of ATP1A1 mRNA

PMID:11675400 PMID:15075188

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Puromycin Aminonucleoside results in increased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

Puromycin Aminonucleoside results in decreased expression of ATP2A2 mRNA; Puromycin Aminonucleoside results in decreased expression of ATP2A2 protein

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

arginine vasopressin

increases expression

Puromycin Aminonucleoside results in increased expression of AVP protein

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of BAX protein
Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]
Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]

PMID:15113391 PMID:15987750 PMID:16152783 PMID:16396944

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 2

decreases activity
decreases expression

Puromycin Aminonucleoside results in decreased activity of BCAT2 protein
Puromycin Aminonucleoside results in decreased expression of BCAT2 mRNA

NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007

G

butyrylcholinesterase

increases activity

Puromycin Aminonucleoside results in increased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions
increases expression

[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein
Puromycin Aminonucleoside results in increased expression of BCL2 protein

PMID:14993511 PMID:15113391 PMID:16152783

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

[Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein]
Dinoprostone affects the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein]

PMID:15987750 PMID:16396944

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

bone gamma-carboxyglutamate protein

increases expression

Puromycin Aminonucleoside results in increased expression of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

baculoviral IAP repeat-containing 5

increases expression

Puromycin Aminonucleoside results in increased expression of BIRC5 mRNA; Puromycin Aminonucleoside results in increased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 7

multiple interactions
decreases expression

1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA]; 1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of BMP7 protein]
Puromycin Aminonucleoside results in decreased expression of BMP7 mRNA; Puromycin Aminonucleoside results in decreased expression of BMP7 protein

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

bone morphogenetic protein receptor type 2

multiple interactions
increases expression

Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]; Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

complement C3

multiple interactions
increases expression
decreases expression

cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of C3 protein]; mizoribine inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of C3 protein]

PMID:8919236 PMID:9250166

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

multiple interactions

CR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]
cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]; Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

complement C9

multiple interactions

CR1 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]
cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]]; Puromycin Aminonucleoside results in increased expression of [C5 protein alternative form binds to C9 protein]

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

caspase 3

multiple interactions
increases activity

Colforsin inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]; Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]; L-161982 promotes the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

increases activity
decreases activity
decreases expression
affects activity
multiple interactions

Puromycin Aminonucleoside results in increased activity of CAT protein
Puromycin Aminonucleoside results in decreased activity of CAT protein
Puromycin Aminonucleoside results in decreased expression of CAT mRNA
Puromycin Aminonucleoside affects the activity of CAT protein
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]; Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of CAT protein; sho-saiko-to-kyo-shokyo-ka-oren-bukuryo inhibits the reaction [Puromycin Aminonucleoside results in decreased activity of CAT protein]

PMID:1744988 PMID:1942778 PMID:6246912 PMID:8289993 PMID:9355075 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 1

affects expression

Puromycin Aminonucleoside affects the expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 2

affects expression
multiple interactions
increases expression

Puromycin Aminonucleoside affects the expression of CCL2 mRNA
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 protein]
Puromycin Aminonucleoside results in increased expression of CCL2 mRNA; Puromycin Aminonucleoside results in increased expression of CCL2 protein

PMID:10867541 PMID:12813006 PMID:16452496

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

affects expression

Puromycin Aminonucleoside affects the expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 7

affects expression

Puromycin Aminonucleoside affects the expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

CD2-associated protein

multiple interactions
decreases expression

celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA]

NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199

G

CD36 molecule

multiple interactions
increases expression

Puromycin Aminonucleoside results in increased expression of and results in increased glycosylation of CD36 protein
Puromycin Aminonucleoside results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD44 molecule

increases expression

Puromycin Aminonucleoside results in increased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 42

multiple interactions

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Estradiol]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Progesterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Testosterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]; CGB3 protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carbohydrate sulfotransferase 11

decreases expression

Puromycin Aminonucleoside results in decreased expression of CHST11 mRNA

NCBI chr 7:20,524,535...20,743,008
Ensembl chr 7:20,528,100...20,743,111

G

chondroitin sulfate synthase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CHSY1 mRNA

NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601

G

claudin 6

affects localization

Puromycin Aminonucleoside affects the localization of CLDN6 protein

NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973

G

chloride intracellular channel 5

decreases expression

Puromycin Aminonucleoside results in decreased expression of CLIC5 protein

NCBI chr 9:16,710,980...16,813,502
Ensembl chr 9:16,710,980...16,813,427

G

collagen type I alpha 1 chain

multiple interactions
increases expression

4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL1A1 mRNA]

PMID:9527400 PMID:16570917

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

increases expression

Puromycin Aminonucleoside results in increased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]

PMID:1762292 PMID:9175058

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

corin, serine peptidase

decreases expression

Puromycin Aminonucleoside results in decreased expression of CORIN mRNA; Puromycin Aminonucleoside results in decreased expression of CORIN protein

NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503

G

catenin beta 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

decreases activity

Puromycin Aminonucleoside results in decreased activity of CTSB protein

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

increases activity

Puromycin Aminonucleoside results in increased activity of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin H

decreases activity

Puromycin Aminonucleoside results in decreased activity of CTSH protein

NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824

G

cathepsin L

decreases response to substance
multiple interactions
decreases activity
affects expression

CTSL gene mutant form results in decreased susceptibility to Puromycin Aminonucleoside
Puromycin Aminonucleoside results in increased activity of and results in increased expression of CTSL protein
Puromycin Aminonucleoside results in decreased activity of CTSL protein
Puromycin Aminonucleoside affects the expression of CTSL mRNA; Puromycin Aminonucleoside affects the expression of CTSL protein

PMID:10394110 PMID:15197181

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; CGB3 protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; FSHB protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

Puromycin Aminonucleoside results in increased expression of CYP24A1 mRNA

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

dopa decarboxylase

decreases activity

Puromycin Aminonucleoside results in decreased activity of DDC protein

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

dendrin

decreases expression

Puromycin Aminonucleoside results in decreased expression of DDN protein

NCBI chr 7:129,953,317...129,957,299
Ensembl chr 7:129,953,318...129,957,341

G

desmin

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of DES protein
triptolide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of DES protein]

PMID:2183627 PMID:18509322

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dynamin 3

increases expression

Puromycin Aminonucleoside results in increased expression of DNM3 mRNA

NCBI chr13:74,359,043...74,838,135
Ensembl chr13:74,359,213...74,838,108

G

endothelin converting enzyme 1

increases expression

Puromycin Aminonucleoside results in increased expression of ECE1 mRNA; Puromycin Aminonucleoside results in increased expression of ECE1 protein

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

enoyl-CoA hydratase, short chain 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

endothelin 1

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP]

PMID:7756592 PMID:9175058 PMID:12972712

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin 3

multiple interactions

Puromycin Aminonucleoside promotes the reaction [EDN3 protein results in increased abundance of Cyclic GMP]

NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093

G

endothelin receptor type A

increases expression

Puromycin Aminonucleoside results in increased expression of EDNRA mRNA

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

multiple interactions
increases expression

Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA]

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

electron transfer flavoprotein subunit alpha

decreases expression

Puromycin Aminonucleoside results in decreased expression of ETFA protein

NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969

G

electron transfer flavoprotein subunit beta

decreases expression

Puromycin Aminonucleoside results in decreased expression of ETFB protein

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

ezrin

decreases expression

Puromycin Aminonucleoside results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

Fas cell surface death receptor

multiple interactions
increases expression

Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein]

PMID:14993511 PMID:16152783

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of FASL protein
Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein]

PMID:14993511 PMID:16152783

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

FAT atypical cadherin 1

increases expression

Puromycin Aminonucleoside results in increased expression of FAT1 mRNA; Puromycin Aminonucleoside results in increased expression of FAT1 protein

NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107

G

Fms related receptor tyrosine kinase 1

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of FLT1 protein
Puromycin Aminonucleoside affects the expression of FLT1 mRNA

PMID:11744811 PMID:14752241

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibronectin 1

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of FN1 mRNA; Puromycin Aminonucleoside results in increased expression of FN1 protein
Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FN1 protein]

PMID:9527400 PMID:12813006

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Estradiol]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Progesterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased abundance of Testosterone]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; [FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]; FSHB protein inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CYP11A1 mRNA]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of FSHB protein]
Puromycin Aminonucleoside results in decreased expression of FSHB protein

PMID:12269381 PMID:16574160

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

G protein subunit alpha q

increases response to substance

GNAQ protein results in increased susceptibility to Puromycin Aminonucleoside

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

gonadotropin releasing hormone 1

multiple interactions

Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of FSHB protein]; Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

glutathione peroxidase 1

multiple interactions
increases expression

[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Puromycin Aminonucleoside results in increased expression of GPX1 mRNA

PMID:1942778 PMID:20685819

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase pi 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

guanylate cyclase activator 2B

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of GUCA2B protein
Puromycin Aminonucleoside affects the expression of GUCA2B mRNA

NCBI chr 5:133,246,891...133,248,941
Ensembl chr 5:133,246,909...133,248,966

G

hydroxyacyl-CoA dehydrogenase

decreases expression

Puromycin Aminonucleoside results in decreased expression of HADH protein

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases activity

Puromycin Aminonucleoside results in increased activity of HMGCR protein

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions
increases expression

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein]
Puromycin Aminonucleoside results in increased expression of HMOX1 mRNA; Puromycin Aminonucleoside results in increased expression of HMOX1 protein

PMID:12806184 PMID:20685819

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heparanase

increases expression

Puromycin Aminonucleoside results in increased expression of HPSE mRNA; Puromycin Aminonucleoside results in increased expression of HPSE protein

NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010

G

heparan sulfate-glucosamine 3-sulfotransferase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HS3ST1 mRNA

NCBI chr14:71,185,826...71,223,263
Ensembl chr14:71,185,682...71,223,248

G

heparan sulfate 6-O-sulfotransferase 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HS6ST1 mRNA

NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Puromycin Aminonucleoside results in decreased activity of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

heat shock protein family A (Hsp70) member 5

decreases expression

Puromycin Aminonucleoside results in decreased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

affects localization

Puromycin Aminonucleoside affects the localization of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family D (Hsp60) member 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

intercellular adhesion molecule 1

increases expression

Puromycin Aminonucleoside results in increased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

increases expression

Puromycin Aminonucleoside results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

integrin-linked kinase

multiple interactions
increases activity

mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased activity of ILK protein]

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

integrin subunit alpha 3

decreases expression
affects expression

Puromycin Aminonucleoside results in decreased expression of ITGA3 mRNA; Puromycin Aminonucleoside results in decreased expression of ITGA3 protein
Puromycin Aminonucleoside affects the expression of ITGA3 protein

PMID:9249603 PMID:10845833 PMID:11274237 PMID:15197181

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit beta 1

decreases expression
increases expression

Puromycin Aminonucleoside results in decreased expression of ITGB1 mRNA; Puromycin Aminonucleoside results in decreased expression of ITGB1 protein
Puromycin Aminonucleoside results in increased expression of ITGB1 protein

PMID:11274237 PMID:12065681 PMID:14559718

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

kinase insert domain receptor

affects expression
increases expression
decreases expression

Puromycin Aminonucleoside affects the expression of KDR mRNA
Puromycin Aminonucleoside results in increased expression of KDR mRNA; Puromycin Aminonucleoside results in increased expression of KDR protein
Puromycin Aminonucleoside results in decreased expression of KDR mRNA

PMID:11744811 PMID:14752241 PMID:17667850

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kirre like nephrin family adhesion molecule 1

multiple interactions
decreases expression

Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of KIRREL1 mRNA]

NCBI chr 2:172,521,644...172,615,057
Ensembl chr 2:172,525,245...172,615,299

G

keratin 7

decreases expression

Puromycin Aminonucleoside results in decreased expression of KRT7 mRNA; Puromycin Aminonucleoside results in decreased expression of KRT7 protein

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

laminin subunit beta 1

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]

PMID:1762292 PMID:9175058

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit beta 2

multiple interactions
increases expression

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]; FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]

PMID:1762292 PMID:9175058

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

lipocalin 2

increases secretion

Puromycin Aminonucleoside results in increased secretion of LCN2 protein

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

galectin 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of LGALS1 protein

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

luteinizing hormone subunit beta

multiple interactions
decreases expression

Puromycin Aminonucleoside inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]
Puromycin Aminonucleoside results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

mitogen activated protein kinase 1

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Puromycin Aminonucleoside binds to and results in increased activity of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

midkine

multiple interactions
decreases expression

Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of MDK mRNA]

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

membrane metallo-endopeptidase

decreases expression

Puromycin Aminonucleoside results in decreased expression of MME protein

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 2

multiple interactions
increases expression

FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

moesin

increases expression

Puromycin Aminonucleoside results in increased expression of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

mitochondrially encoded cytochrome c oxidase I

decreases expression

Puromycin Aminonucleoside results in decreased expression of COX1 protein

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

myosin heavy chain 10

increases expression
affects expression

Puromycin Aminonucleoside results in increased expression of MYH10 protein
Puromycin Aminonucleoside affects the expression of MYH10 mRNA; Puromycin Aminonucleoside affects the expression of MYH10 protein

PMID:7671567 PMID:8918620

NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165

G

myosin heavy chain 6

affects expression

Puromycin Aminonucleoside affects the expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

napsin A aspartic peptidase

increases expression

Puromycin Aminonucleoside results in increased expression of NAPSA mRNA; Puromycin Aminonucleoside results in increased expression of NAPSA protein

NCBI chr 1:95,064,726...95,077,101
Ensembl chr 1:95,064,900...95,077,094

G

N-deacetylase and N-sulfotransferase 1

decreases expression
affects expression

Puromycin Aminonucleoside results in decreased expression of NDST1 mRNA
Puromycin Aminonucleoside affects the expression of NDST1 mRNA

NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191

G

nebulette

decreases expression

Puromycin Aminonucleoside results in decreased expression of NEBL mRNA

NCBI chr17:80,113,891...80,466,331
Ensembl chr17:80,118,543...80,466,210

G

NEDD4 like E3 ubiquitin protein ligase

decreases expression

Puromycin Aminonucleoside results in decreased expression of NEDD4L protein

NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137

G

nitric oxide synthase 1

multiple interactions
increases expression

Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of NOS1 protein
Puromycin Aminonucleoside results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases expression

Puromycin Aminonucleoside results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of NOS3 mRNA
Puromycin Aminonucleoside results in decreased expression of and results in decreased activity of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NPHS1 adhesion molecule, nephrin

multiple interactions
decreases phosphorylation
decreases expression
affects expression

triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]
Puromycin Aminonucleoside results in decreased phosphorylation of NPHS1 protein
Puromycin Aminonucleoside results in decreased expression of NPHS1; Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA; Puromycin Aminonucleoside results in decreased expression of NPHS1 protein
1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; 1,25-dihydroxyvitamin D inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; fasudil inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; Mercuric Chloride promotes the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; Puromycin Aminonucleoside affects the expression of and affects the localization of NPHS1 protein; Puromycin Aminonucleoside promotes the reaction [Mercuric Chloride results in decreased expression of NPHS1 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]; Tretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]; triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein]
Puromycin Aminonucleoside affects the expression of NPHS1 mRNA; Puromycin Aminonucleoside affects the expression of NPHS1 protein

PMID:10792613 PMID:11012881 PMID:12012391 PMID:12065681 PMID:12386277 More...

NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078

G

NPHS2 stomatin family member, podocin

decreases expression
multiple interactions
affects expression

Puromycin Aminonucleoside results in decreased expression of NPHS2 protein
triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS2 protein]
Puromycin Aminonucleoside affects the expression of NPHS2 mRNA; Puromycin Aminonucleoside affects the expression of NPHS2 protein

PMID:12065681 PMID:15363039 PMID:18509322

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

natriuretic peptide A

affects metabolic processing
increases response to substance
increases expression
multiple interactions
affects expression

Puromycin Aminonucleoside affects the metabolism of NPPA protein
Puromycin Aminonucleoside results in increased susceptibility to NPPA protein
Puromycin Aminonucleoside results in increased expression of NPPA mRNA; Puromycin Aminonucleoside results in increased expression of NPPA protein
Puromycin Aminonucleoside inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP]
Puromycin Aminonucleoside affects the expression of NPPA protein

PMID:2526952 PMID:12972712 PMID:15590761 PMID:19885019 PMID:20613715

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

affects expression

Puromycin Aminonucleoside affects the expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

natriuretic peptide receptor 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of NPR1 mRNA

NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505

G

natriuretic peptide receptor 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of NPR3 mRNA

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955

G

nuclear respiratory factor 1

affects expression

Puromycin Aminonucleoside affects the expression of NRF1 mRNA

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

optineurin

increases expression

Puromycin Aminonucleoside results in increased expression of OPTN protein

NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251

G

podoplanin

decreases expression

Puromycin Aminonucleoside results in decreased expression of PDPN mRNA; Puromycin Aminonucleoside results in decreased expression of PDPN protein

PMID:9327748 PMID:12032185

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

G

pleckstrin homology, MyTH4 and FERM domain containing H2

decreases expression

Puromycin Aminonucleoside results in decreased expression of PLEKHH2 protein

NCBI chr 6:10,032,837...10,132,081
Ensembl chr 6:10,032,660...10,140,794

G

phospholamban

increases expression

Puromycin Aminonucleoside results in increased expression of PLN mRNA

NCBI chr20:32,629,537...32,639,559

G

podocalyxin-like

increases expression
affects metabolic processing

Puromycin Aminonucleoside results in increased expression of PODXL mRNA; Puromycin Aminonucleoside results in increased expression of PODXL protein
Puromycin Aminonucleoside affects the metabolism of PODXL protein

PMID:8780404 PMID:11274237

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase beta

increases expression
multiple interactions

Puromycin Aminonucleoside results in increased expression of POLB protein
1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of POLB protein]

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

pioglitazone affects the reaction [Puromycin Aminonucleoside results in increased expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 12A

increases phosphorylation
increases expression
multiple interactions

Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein
Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form
Y 27632 inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of PPP1R12A protein]
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form]

PMID:16452496 PMID:18367845

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

peroxiredoxin 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of PRDX3 protein

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

prostaglandin-endoperoxide synthase 2

increases expression
affects response to substance
multiple interactions

Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA; Puromycin Aminonucleoside results in increased expression of PTGS2 protein
PTGS2 protein affects the susceptibility to Puromycin Aminonucleoside
celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PTGS2 mRNA]

PMID:16396944 PMID:17890881 PMID:19194550

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

increases expression

Puromycin Aminonucleoside results in increased expression of PTH protein

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

protein tyrosine kinase 2

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, receptor type, O

affects expression

Puromycin Aminonucleoside affects the expression of PTPRO mRNA; Puromycin Aminonucleoside affects the expression of PTPRO protein

NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771

G

retinoic acid receptor, alpha

increases expression

Puromycin Aminonucleoside results in increased expression of RARA mRNA; Puromycin Aminonucleoside results in increased expression of RARA protein

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RB binding protein 7, chromatin remodeling factor

decreases expression

Puromycin Aminonucleoside results in decreased expression of RBBP7 protein

NCBI chr X:31,913,080...31,931,245
Ensembl chr X:31,913,081...31,931,226

G

renin

multiple interactions
increases expression
affects expression

Puromycin Aminonucleoside affects the expression of and affects the activity of REN protein; Puromycin Aminonucleoside results in increased expression of and results in increased activity of REN protein
Puromycin Aminonucleoside results in increased expression of REN protein
Puromycin Aminonucleoside affects the expression of REN protein

PMID:2236972 PMID:2267444 PMID:8446257 PMID:9171944

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ras homolog family member A

multiple interactions
increases expression

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

sodium channel epithelial 1 subunit alpha

affects expression
multiple interactions
decreases expression
affects localization

Puromycin Aminonucleoside affects the expression of SCNN1A mRNA
Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1A protein
Puromycin Aminonucleoside results in decreased expression of SCNN1A mRNA
Puromycin Aminonucleoside affects the localization of SCNN1A protein

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

sodium channel epithelial 1 subunit beta

affects expression
increases expression
decreases expression
multiple interactions
affects localization

Puromycin Aminonucleoside affects the expression of SCNN1B mRNA
Puromycin Aminonucleoside results in increased expression of SCNN1B mRNA
Puromycin Aminonucleoside results in decreased expression of SCNN1B mRNA
Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1B protein
Puromycin Aminonucleoside affects the localization of SCNN1B protein

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451

G

sodium channel epithelial 1 subunit gamma

multiple interactions
increases expression
decreases expression

Puromycin Aminonucleoside affects the localization of and affects the expression of SCNN1G protein; Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1G protein
Puromycin Aminonucleoside results in increased expression of SCNN1G mRNA
Puromycin Aminonucleoside results in decreased expression of SCNN1G mRNA

PMID:12653683 PMID:15075188 PMID:16020936 PMID:16267158

NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816

G

serpin family E member 1

multiple interactions
increases expression

pioglitazone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 12 member 1

decreases expression

Puromycin Aminonucleoside results in decreased expression of SLC12A1 protein

NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899

G

solute carrier family 12 member 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of SLC12A3 protein

NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091

G

solute carrier family 22 member 2

affects expression

Puromycin Aminonucleoside affects the expression of SLC22A2 mRNA

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 29 member 4

increases response to substance

SLC29A4 results in increased susceptibility to Puromycin Aminonucleoside

NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834

G

solute carrier family 5 member 3

increases expression

Puromycin Aminonucleoside results in increased expression of SLC5A3 mRNA

NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883

G

solute carrier family 9 member A3

multiple interactions
decreases expression
affects expression

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]
Puromycin Aminonucleoside affects the expression of SLC9A3 protein

PMID:12191963 PMID:12806184 PMID:15075188

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

SMAD family member 1

increases expression

Puromycin Aminonucleoside results in increased expression of SMAD1 mRNA

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

superoxide dismutase 2

affects expression
decreases expression
multiple interactions

Puromycin Aminonucleoside affects the expression of SOD2 protein
Puromycin Aminonucleoside results in decreased expression of SOD2 protein
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein

PMID:1942778 PMID:19264907

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

secreted phosphoprotein 1

multiple interactions
increases expression

Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 protein]; fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 mRNA]
Puromycin Aminonucleoside results in increased expression of SPP1 mRNA; Puromycin Aminonucleoside results in increased expression of SPP1 protein

PMID:14738908 PMID:16452496

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Puromycin Aminonucleoside results in increased expression of and results in increased phosphorylation of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression

[FSHB protein co-treated with CGB3 protein] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

synaptopodin

decreases expression

Puromycin Aminonucleoside results in decreased expression of SYNPO protein

NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126

G

transgelin

increases expression

Puromycin Aminonucleoside results in increased expression of TAGLN mRNA; Puromycin Aminonucleoside results in increased expression of TAGLN protein

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

TEK receptor tyrosine kinase

decreases expression

Puromycin Aminonucleoside results in decreased expression of TEK mRNA

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transferrin

increases expression

Puromycin Aminonucleoside results in increased expression of TF mRNA

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor A, mitochondrial

affects expression

Puromycin Aminonucleoside affects the expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transforming growth factor, beta 1

multiple interactions
increases expression
affects expression

Celecoxib inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 protein]; Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]
Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA; Puromycin Aminonucleoside results in increased expression of TGFB1 protein
Puromycin Aminonucleoside affects the expression of TGFB1 mRNA

PMID:9527400 PMID:12397044 PMID:14738908 PMID:19194550 PMID:19594554

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

multiple interactions
increases expression

FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TIMP1 mRNA]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tight junction protein 1

multiple interactions
increases expression
affects localization

Cyclosporine inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TJP1 protein]
Puromycin Aminonucleoside affects the localization of TJP1 protein

PMID:15744817 PMID:15798086

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tumor necrosis factor

multiple interactions
increases expression

Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]

PMID:8384958 PMID:17457379

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin C1, slow skeletal and cardiac type

decreases expression

Puromycin Aminonucleoside results in decreased expression of TNNC1 mRNA

NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634

G

tumor protein p53

multiple interactions
increases expression

1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]
Puromycin Aminonucleoside results in increased expression of TRP53 protein
1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]; Dexamethasone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TRP53 protein]

PMID:14993511 PMID:15113391 PMID:15987750 PMID:16152783 PMID:17035936

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transthyretin

increases expression

Puromycin Aminonucleoside results in increased expression of TTR protein

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

uncoupling protein 3

decreases expression

Puromycin Aminonucleoside results in decreased expression of UCP3 protein

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

versican

decreases expression

Puromycin Aminonucleoside results in decreased expression of VCAN mRNA; Puromycin Aminonucleoside results in decreased expression of VCAN protein

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

vinculin

affects localization
increases expression

Puromycin Aminonucleoside affects the localization of VCL protein
Puromycin Aminonucleoside results in increased expression of VCL mRNA; Puromycin Aminonucleoside results in increased expression of VCL protein

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

vascular endothelial growth factor A

affects expression
increases expression

Puromycin Aminonucleoside affects the expression of VEGFA mRNA
Puromycin Aminonucleoside results in increased expression of VEGFA protein

PMID:11744811 PMID:14752241

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

multiple interactions
increases expression

fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of VIM mRNA]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

WT1 interacting protein

affects localization

Puromycin Aminonucleoside affects the localization of WTIP protein

NCBI chr 1:86,731,214...86,764,939
Ensembl chr 1:86,731,265...86,765,014

G

X-C motif chemokine ligand 1

affects expression

Puromycin Aminonucleoside affects the expression of XCL1 mRNA

NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329

G

xanthine dehydrogenase

increases activity
multiple interactions

Puromycin Aminonucleoside results in increased activity of XDH
[Tungsten co-treated with Puromycin Aminonucleoside] results in decreased activity of XDH protein

PMID:7583048 PMID:11041286

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

3'-phospho-5'-adenylyl sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

[NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

N-acetyltransferase 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

purinergic receptor P2Y1

decreases activity

Phosphoadenosine Phosphosulfate results in decreased activity of P2RY1 protein

NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457

G

sulfotransferase family 1A member 1

multiple interactions
increases sulfation

2,2',3,4,4',5',6-heptabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Halogenated Diphenyl Ethers analog inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; pentabrominated diphenyl ether 100 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; Pentachlorophenol inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tribromodiphenyl ether 28 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]
SULT1A1 protein results in increased sulfation of Phosphoadenosine Phosphosulfate

PMID:11425650 PMID:16601080 PMID:20545351

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 2A member 1

multiple interactions

[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol; Celecoxib affects the reaction [[Phosphoadenosine Phosphosulfate co-treated with SULT2A1 protein] affects the sulfation of Ethinyl Estradiol]; SULT2A1 protein affects the metabolism of [Phosphoadenosine Phosphosulfate co-treated with Ethinyl Estradiol]

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

3-iodobenzyl-5'-N-methylcarboxamidoadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A3 receptor

multiple interactions

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate; [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein

PMID:12672554 PMID:15452191 PMID:19966059

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

AKT serine/threonine kinase 1

multiple interactions

Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

baculoviral IAP repeat-containing 3

decreases expression
decreases response to substance

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of BIRC3 mRNA
BIRC3 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases response to substance

BIRC5 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

interleukin 12A

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

NLR family, apoptosis inhibitory protein 6

decreases response to substance
decreases expression

NAIP protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of NAIP mRNA

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

natriuretic peptide A

multiple interactions

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:15452191 PMID:19966059

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

regulator of G-protein signaling 2

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

solute carrier family 9 member A1

multiple interactions

N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

5'-S-methyl-5'-thioadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Acta2 mRNA in Mdr2-/- mouse liver and liver myofibroblasts

RGD

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adenosine A2B receptor

multiple interactions

5'-S-methyl-5'-thioadenosine enhances the reaction [lipopolysaccharide increases expression of Adora2b mRNA in mouse liver myofibroblasts]

RGD

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein
IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

C-C motif chemokine ligand 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Ccl2 mRNA in Mdr2-/- mouse liver and myofibroblasts

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of cyclin-D1 mRNA in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

collagen type I alpha 1 chain

decreases expression

5'-methylthioadenosine results in decreased expression of COL1A1 mRNA
5'-S-methyl-5'-thioadenosine decreases expression of Col1a1 mRNA in Mdr2-/- mouse liver and liver myofibroblasts

CTD
RGD

PMID:15983038 PMID:21209952

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

decreases expression

5'-methylthioadenosine results in decreased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

isocitrate dehydrogenase (NADP(+)) 2

increases abundance
multiple interactions

IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interferon gamma

multiple interactions
decreases secretion

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA]
5'-methylthioadenosine results in decreased secretion of IFNG protein

PMID:17080400 PMID:31712395

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon, lambda 1

multiple interactions

5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA]

NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235

G

interleukin 1 beta

multiple interactions

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions
decreases secretion

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA]
5'-methylthioadenosine results in decreased secretion of IL2 protein

PMID:17080400 PMID:31712395

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 33

multiple interactions

5'-methylthioadenosine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA]

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 6

multiple interactions
decreases expression

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
5'-S-methyl-5'-thioadenosine decreases expression of Il6 mRNA in Mdr2-/- mouse liver

CTD
RGD

PMID:17080400 PMID:21209952

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7

multiple interactions

IL7 protein inhibits the reaction [5'-methylthioadenosine results in decreased phosphorylation of AKT1 protein]

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of JunD protein in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lymphotoxin beta

multiple interactions

5'-methylthioadenosine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA]

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

MDM4 regulator of p53

multiple interactions

5'-methylthioadenosine affects the splicing of and affects the expression of MDM4 mRNA alternative form

NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226

G

marker of proliferation Ki-67

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Ki-67 protein in Mdr2-/- mouse liver

RGD

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 13

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of MMP13 mRNA in Mdr2-/- mouse liver

RGD

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

mechanistic target of rapamycin kinase

decreases phosphorylation

5'-methylthioadenosine results in decreased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

nitric oxide synthase 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of iNOS mRNA in Mdr2-/- mouse liver

RGD

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

ribosomal protein S6

decreases phosphorylation

5'-methylthioadenosine results in decreased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

transforming growth factor, beta 1

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Tgfb1 mRNA in Mdr2-/- mouse liver myofibroblasts

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of Tgfb2 mRNA in Mdr2-/- mouse liver and myofibroblasts

RGD

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

tenascin C

decreases expression

5'-S-methyl-5'-thioadenosine decreases expression of tenascin-C mRNA in Mdr2-/- mouse liver

RGD

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions

5'-S-methyl-5'-thioadenosine inhibits the reaction [lipopolysaccharide increases expression of Tnf-alpha mRNA and protein in mouse liver myofibroblasts]

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

5'-methylthioadenosine results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

acetoacetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid (17-beta) dehydrogenase 2

affects binding

acetoacetyl CoA binds to HSD17B2 protein

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

acetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP citrate lyase

increases abundance

ACLY protein results in increased abundance of Acetyl Coenzyme A

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

amyloid beta precursor protein

affects localization
increases secretion
multiple interactions

APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

PMID:16122837 PMID:22906069

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

carnitine O-acetyltransferase

decreases activity

Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

ERCC excision repair 6, chromatin remodeling factor

decreases abundance
multiple interactions

ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Fluoxetine results in decreased expression of G6PC1 protein] which results in increased abundance of Acetyl Coenzyme A

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 1 beta

multiple interactions

IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

lysine acetyltransferase 2B

affects binding

Acetyl Coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

G

meteorin-like, glial cell differentiation regulator

multiple interactions

METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A]

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

G

N-acetyltransferase 1

multiple interactions
affects binding

[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein

PMID:20545351 PMID:22835378

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

acryloyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

enoyl-CoA hydratase, short chain 1

increases abundance

ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

3-hydroxyisobutyryl-CoA hydrolase

increases abundance

HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

adenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

decreases metabolic processing
increases metabolic processing

ADA alternative form results in decreased metabolism of Adenosine
ADA protein results in increased metabolism of Adenosine

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adenosine A1 receptor

multiple interactions
affects binding

Adenosine analog binds to and affects the activity of ADORA1 protein; Adenosine analog binds to and results in decreased activity of ADORA1 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein]
Adenosine binds to ADORA1 protein
[lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine; Adenosine analog binds to and results in increased activity of ADORA1 protein

PMID:10649980 PMID:11520205 PMID:18404447 PMID:20571079 PMID:20932874

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

multiple interactions
affects binding

Adenosine analog binds to and results in decreased activity of ADORA2A protein; Adenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA]
Adenosine binds to ADORA2A protein

PMID:18404447 PMID:20067761

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A2B receptor

affects response to substance

ADORA2B protein affects the susceptibility to Adenosine

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

adenosine A3 receptor

multiple interactions
increases expression
affects binding

Adenosine analog binds to and affects the activity of ADORA3 protein; Adenosine analog binds to and results in decreased activity of ADORA3 protein; Adenosine analog binds to and results in increased activity of ADORA3 protein; PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]; VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein]
Adenosine results in increased expression of ADORA3 mRNA
Adenosine binds to ADORA3 protein

PMID:11520205 PMID:18404447 PMID:20067761 PMID:20571079

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

alkaline phosphatase, intestinal

multiple interactions

Adenosine inhibits the reaction [Methotrexate results in increased activity of ALPI protein]

NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877

G

adenosine monophosphate deaminase 2

multiple interactions

[tofacitinib results in decreased expression of AMPD2 protein] which affects the abundance of Adenosine

NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271

G

BCL2 associated X, apoptosis regulator

increases localization
multiple interactions

Adenosine results in increased localization of BAX protein
Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

decreases expression
multiple interactions

Adenosine results in decreased expression of BCL2L1 mRNA; Adenosine results in decreased expression of BCL2L1 protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 2

decreases expression

Adenosine results in decreased expression of BIRC2 mRNA; Adenosine results in decreased expression of BIRC2 protein

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

decreases expression

Adenosine results in decreased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

bone morphogenetic protein 2

increases expression

Adenosine results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

increases expression
multiple interactions

Adenosine results in increased expression of BMP4 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]; PSB603 inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]; ZM 241385 inhibits the reaction [Adenosine results in increased expression of BMP4 mRNA]

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein receptor type 1A

increases expression

Adenosine results in increased expression of BMPR1A mRNA

NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616

G

caspase 3

multiple interactions
increases activity

Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein]

PMID:11570579 PMID:16469385 PMID:17303086 PMID:20063052

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity
multiple interactions

Adenosine results in increased activity of CASP8 protein
Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein]

PMID:16469385 PMID:17303086

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
multiple interactions

Adenosine results in increased activity of CASP9 protein
Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein]

PMID:11570579 PMID:16469385

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin D1

increases expression

Adenosine results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD14 molecule

increases expression

Adenosine results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CASP8 and FADD-like apoptosis regulator

decreases expression
multiple interactions

Adenosine results in decreased expression of CFLAR mRNA; Adenosine results in decreased expression of CFLAR mRNA alternative form; Adenosine results in decreased expression of CFLAR protein
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein]

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

CF transmembrane conductance regulator

increases activity
multiple interactions

Adenosine results in increased activity of CFTR protein
[Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

cAMP responsive element binding protein 1

increases expression
multiple interactions

Adenosine results in increased expression of CREB1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]; PSB603 inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]; ZM 241385 inhibits the reaction [Adenosine results in increased expression of CREB1 mRNA]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

catenin beta 1

increases expression

Adenosine results in increased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

diablo, IAP-binding mitochondrial protein

increases expression
multiple interactions

Adenosine results in increased expression of DIABLO mRNA; Adenosine results in increased expression of DIABLO protein
Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein]

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

Adenosine results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dipeptidylpeptidase 4

decreases expression
multiple interactions

Adenosine results in decreased expression of DPP4 mRNA; Adenosine results in decreased expression of DPP4 protein
[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

epidermal growth factor

increases expression
multiple interactions

Adenosine results in increased expression of EGF mRNA
Adenosine results in increased expression of and results in increased secretion of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

estrogen receptor 1

increases expression

Adenosine results in increased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases expression

Adenosine results in increased expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fas associated via death domain

decreases expression
multiple interactions

Adenosine results in decreased expression of FADD mRNA
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas ligand

increases expression
multiple interactions

Adenosine results in increased expression of FASLG protein
[Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA

PMID:11992407 PMID:16419169

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 6

multiple interactions

Adenosine results in increased expression of and results in increased secretion of FGF6 protein

NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447

G

follicle stimulating hormone subunit beta

increases expression

Adenosine results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

frizzled class receptor 3

increases expression

Adenosine results in increased expression of FZD3 mRNA

NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369

G

frizzled class receptor 5

increases expression

Adenosine results in increased expression of FZD5 mRNA

NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457

G

glial cell derived neurotrophic factor

increases secretion

Adenosine results in increased secretion of GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glycogen synthase kinase 3 beta

increases phosphorylation
increases expression

Adenosine results in increased phosphorylation of GSK3B protein
Adenosine results in increased expression of GSK3B mRNA

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

granzyme B

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA

NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814

G

H2A.X variant histone

multiple interactions

Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hypoxia inducible factor 1 subunit alpha

increases expression

Adenosine results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

isocitrate dehydrogenase (NADP(+)) 2

increases abundance
multiple interactions

IDH2 protein mutant form results in increased abundance of Adenosine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interferon gamma

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

affects expression
multiple interactions

Adenosine affects the expression of IGF1 mRNA
Adenosine results in increased expression of and results in increased secretion of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

multiple interactions

Adenosine results in increased expression of and results in increased secretion of IGF2 protein

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

interleukin 10

multiple interactions
increases expression

Adenosine promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Adenosine results in increased expression of IL10 mRNA; Adenosine results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

decreases expression
multiple interactions

Adenosine results in decreased expression of IL12B protein
Adenosine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 beta

multiple interactions

Adenosine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

multiple interactions

Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 2

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

lymphoid enhancer binding factor 1

increases expression

Adenosine results in increased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

lymphocyte antigen 96

increases expression

Adenosine results in increased expression of LY96 mRNA

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

G

mitogen activated protein kinase kinase 1

increases phosphorylation

Adenosine results in increased phosphorylation of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

increases phosphorylation

Adenosine results in increased phosphorylation of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

Adenosine results in decreased phosphorylation of MAPK3 protein
[Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA; [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

marker of proliferation Ki-67

affects expression

Adenosine affects the expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mechanistic target of rapamycin kinase

increases phosphorylation

Adenosine results in increased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression
multiple interactions

Adenosine results in decreased expression of MYC protein
Adenosine results in increased expression of MYC mRNA
Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein]; Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein]

PMID:9808420 PMID:34070360

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NFKB inhibitor alpha

multiple interactions

[Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

decreases stability
multiple interactions

Adenosine results in decreased stability of NOS2 mRNA
Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Adenosine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

5' nucleotidase, ecto

multiple interactions

[alpha,beta-methyleneadenosine 5'-diphosphate results in decreased activity of NT5E protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

placental growth factor

increases secretion

Adenosine results in increased secretion of PGF protein

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

PPARG coactivator 1 alpha

increases expression

Adenosine results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

perforin 1

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA

NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701

G

prostaglandin D2 receptor

multiple interactions

[Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosine; [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosine

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

decreases secretion

Adenosine results in decreased secretion of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

receptor interacting serine/threonine kinase 1

multiple interactions

[Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

ribosomal protein S6 kinase B1

increases phosphorylation

Adenosine results in increased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 28 member 1

affects transport
multiple interactions

SLC28A1 protein affects the transport of Adenosine
Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]

NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464

G

solute carrier family 28 member 2

increases transport

SLC28A2 protein results in increased transport of Adenosine

NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702

G

solute carrier family 29 member 1

multiple interactions
increases uptake
affects abundance

4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; [4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]; [SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine; Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]
SLC29A1 protein alternative form results in increased uptake of Adenosine; SLC29A1 protein results in increased uptake of Adenosine
cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; draflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Ethanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Ticagrelor inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]
Adenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
SLC29A1 affects the abundance of Adenosine

PMID:9353301 PMID:9396714 PMID:11179696 PMID:21283641 PMID:21872611 More...

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier family 29 member 2

increases uptake

SLC29A2 protein results in increased uptake of Adenosine

NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171

G

solute carrier family 29 member 3

affects transport

SLC29A3 protein affects the transport of Adenosine

NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388

G

solute carrier family 5 member 5

increases expression

Adenosine results in increased expression of SLC5A5 mRNA; Adenosine results in increased expression of SLC5A5 protein

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

G

transforming growth factor alpha

increases secretion

Adenosine results in increased secretion of TGFA protein

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

increases expression

Adenosine results in increased expression of TGFB1 mRNA; Adenosine results in increased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

increases expression
multiple interactions

Adenosine results in increased expression of TGFB2 mRNA
Adenosine results in increased expression of and results in increased secretion of TGFB2 protein

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

toll-like receptor 4

increases expression
affects localization
multiple interactions

Adenosine results in increased expression of TLR4 mRNA
Adenosine affects the localization of TLR4 protein
Adenosine promotes the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression

5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; ZM 241385 inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]
Adenosine results in decreased expression of TNF protein

PMID:11023991 PMID:21538184 PMID:24224954

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions

[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF superfamily member 10

multiple interactions

[Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53 binding protein 1

multiple interactions

Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

G

uridine phosphorylase 1

increases metabolic processing

UPP1 protein results in increased metabolism of Adenosine

NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462

G

vascular endothelial growth factor A

multiple interactions
increases expression
increases secretion

Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Adenosine results in increased expression of and results in increased secretion of VEGFA protein
Adenosine results in increased expression of VEGFA mRNA
Adenosine results in increased secretion of VEGFA protein

PMID:20067761 PMID:34070360

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

adenosine 3',5'-bismonophosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

sulfotransferase family 1A member 1

multiple interactions

Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

multiple interactions

[2,2',4,4'-tetrabromodiphenyl ether metabolite co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; [tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein; Estradiol inhibits the reaction [[tetrabromobisphenol A co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with adenosine 3'-phosphate-5'-phosphate] binds to SULT1E1 protein]

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 2A member 1

affects binding
multiple interactions

adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein
Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

adenosine 5'-(hexahydrogen pentaphosphate)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nudix hydrolase 11

multiple interactions

[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate

NCBI chr X:16,326,775...16,333,396
Ensembl chr X:16,326,598...16,333,145

adenosine 5'-[gamma-thio]triphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Cd80 molecule

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

interleukin 10

decreases expression

adenosine 5'-O-(3-thiotriphosphate) results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL12B protein

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 beta

increases expression

adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

purinergic receptor P2X 7

affects response to substance

P2RX7 protein affects the susceptibility to adenosine 5'-O-(3-thiotriphosphate)

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

prostaglandin D2 receptor

multiple interactions

adenosine 5'-O-(3-thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

G

transient receptor potential cation channel, subfamily V, member 1

increases activity
multiple interactions

adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein
Capsaicin promotes the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

adenosine 5'-monophosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 9

multiple interactions

Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

[4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

ERCC excision repair 6, chromatin remodeling factor

increases abundance

ERCC6 gene mutant form results in increased abundance of Adenosine Monophosphate

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

H2A.X variant histone

multiple interactions

Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

potassium inwardly-rectifying channel, subfamily J, member 11

multiple interactions

Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

G

nudix hydrolase 11

multiple interactions

[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate

NCBI chr X:16,326,775...16,333,396
Ensembl chr X:16,326,598...16,333,145

G

PPARG coactivator 1 alpha

increases expression

Adenosine Monophosphate results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

tumor protein p53 binding protein 1

multiple interactions

Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

G

tumor protein p73

affects abundance

TP73 protein affects the abundance of Adenosine Monophosphate

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

ADP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions
affects binding

estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; Vanadates promotes the reaction [Adenosine Diphosphate binds to ABCC1 protein]
Adenosine Diphosphate binds to ABCC1 protein; Adenosine Diphosphate binds to ABCC1 protein mutant form

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

aryl hydrocarbon receptor

multiple interactions

Adenosine Diphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 1

increases abundance

AK1 protein results in increased abundance of Adenosine Diphosphate

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

albumin

decreases secretion
multiple interactions

Adenosine Diphosphate results in decreased secretion of ALB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

Axl receptor tyrosine kinase

decreases response to substance

AXL protein results in decreased susceptibility to Adenosine Diphosphate

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

catalase

multiple interactions

CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CD40 ligand

increases expression
multiple interactions

Adenosine Diphosphate results in increased expression of CD40LG protein
clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein]

PMID:11297035 PMID:17043144

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CF transmembrane conductance regulator

multiple interactions

Adenosine Diphosphate binds to and results in decreased activity of CFTR protein; P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

cysteine and histidine rich domain containing 1

multiple interactions

Adenosine Diphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Diphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid]

PMID:16772608 PMID:18004210 PMID:18394438

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

deoxythymidylate kinase

multiple interactions

DTYMK protein binds to [N1-(4-bis(pivaloyloxymethyl)phosphinylbuten-2-yl)thymine co-treated with Adenosine Diphosphate]

NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870

G

dual specificity phosphatase 1

multiple interactions

Adenosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP1 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP1 protein]]

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

multiple interactions

Adenosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP6 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP6 protein]]

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

Eph receptor A4

increases phosphorylation
multiple interactions

Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein
Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
decreases activity

Adenosine Diphosphate inhibits the reaction [ERN1 protein binds to ERN1 protein]
Adenosine Diphosphate results in decreased activity of ERN1 protein

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

coagulation factor II, thrombin

increases abundance
multiple interactions

F2 protein results in increased abundance of Adenosine Diphosphate
Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]; resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fibrinogen alpha chain

multiple interactions
increases secretion

Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein]

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen beta chain

decreases secretion
multiple interactions

Adenosine Diphosphate results in decreased secretion of FGB protein
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibrinogen gamma chain

increases secretion
multiple interactions

Adenosine Diphosphate results in increased secretion of FGG protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein]

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest specific 6

increases response to substance

GAS6 protein results in increased susceptibility to Adenosine Diphosphate

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

H2A.X variant histone

multiple interactions

Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]; U 0126 inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

HRas proto-oncogene, GTPase

multiple interactions

Adenosine Diphosphate binds to and affects the folding of HRAS protein

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein 90 alpha family class A member 1

multiple interactions

Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions
increases abundance

Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interleukin 6

increases expression
multiple interactions

Adenosine Diphosphate results in increased expression of IL6 protein
MRS 2211 inhibits the reaction [Adenosine Diphosphate results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha 2

multiple interactions

ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha 2b

multiple interactions

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]

NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168

G

integrin subunit beta 1 binding protein 2

multiple interactions

Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Diphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr X:66,572,537...66,577,174
Ensembl chr X:66,572,537...66,577,174

G

integrin subunit beta 3

multiple interactions

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Adenosine Diphosphate results in increased phosphorylation of MAPK1 protein
Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK1 protein]]

PMID:15034929 PMID:32941855

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Adenosine Diphosphate results in increased phosphorylation of MAPK3 protein
Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK3 protein]]

PMID:15034929 PMID:32941855

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MER proto-oncogene, tyrosine kinase

increases response to substance

MERTK protein results in increased susceptibility to Adenosine Diphosphate

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

nitric oxide synthase 2

multiple interactions

NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

5' nucleotidase, ecto

decreases activity

Adenosine Diphosphate analog results in decreased activity of NT5E protein

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

purinergic receptor P2Y12

affects response to substance
increases response to substance
multiple interactions

P2RY12 gene polymorphism affects the susceptibility to Adenosine Diphosphate; P2RY12 protein affects the susceptibility to Adenosine Diphosphate
P2RY12 protein results in increased susceptibility to Adenosine Diphosphate
Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]
P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]

PMID:11196645 PMID:11413167 PMID:18404433 PMID:23849096

NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361

G

platelet derived growth factor subunit B

increases secretion
multiple interactions

Adenosine Diphosphate results in increased secretion of PDGFB protein
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein]

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet factor 4

increases secretion
multiple interactions

Adenosine Diphosphate results in increased secretion of PF4 protein
silidianin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]; Silybin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]; silychristin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]

PMID:19428933 PMID:29439388

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

phosphofructokinase, muscle

multiple interactions

Adenosine Diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein]

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

phosphoglycolate phosphatase

decreases phosphorylation

PGP protein results in decreased phosphorylation of Adenosine Diphosphate

NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858

G

pro-platelet basic protein

increases secretion

Adenosine Diphosphate results in increased secretion of PPBP protein

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

G

protein phosphatase 5, catalytic subunit

multiple interactions

Adenosine Diphosphate binds to and affects the folding of PPP5C protein

NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456

G

protein tyrosine phosphatase, non-receptor type 1

increases glutathionylation
multiple interactions

Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein
CAT protein inhibits the reaction [Adenosine Diphosphate results in increased glutathionylation of PTPN1 protein]

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

selectin P

multiple interactions
increases expression

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]; P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; Quercetin inhibits the reaction [Adenosine Diphosphate results in increased expression of SELP protein]

PMID:9740346 PMID:18394438 PMID:18404433 PMID:23249183

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

sirtuin 3

decreases abundance

SIRT3 protein results in decreased abundance of Adenosine Diphosphate

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

transaldolase 1

increases abundance

TALDO1 gene mutant form results in increased abundance of Adenosine Diphosphate

NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974

G

thrombospondin 1

increases secretion

Adenosine Diphosphate results in increased secretion of THBS1 protein

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

tumor protein p53 binding protein 1

multiple interactions

Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]; Anthraquinones analog inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]; U 0126 inhibits the reaction [Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

G

TYRO3 protein tyrosine kinase

increases response to substance

TYRO3 protein results in increased susceptibility to Adenosine Diphosphate

NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142

G

vasodilator-stimulated phosphoprotein

increases phosphorylation
multiple interactions

Adenosine Diphosphate results in increased phosphorylation of VASP protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of VASP protein]

NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061

ADP-D-ribose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADP-ribosylarginine hydrolase

increases hydrolysis

ADPRH protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite

NCBI chr11:62,299,831...62,306,170
Ensembl chr11:62,299,793...62,306,931

G

ADP-ribosylserine hydrolase

increases hydrolysis
multiple interactions

ADPRS protein results in increased hydrolysis of Adenosine Diphosphate Ribose metabolite
Adenosine Diphosphate Ribose inhibits the reaction [ADPRS protein results in increased hydrolysis of O-Acetyl-ADP-Ribose]

NCBI chr 5:138,614,022...138,619,296
Ensembl chr 5:138,614,022...138,619,296

G

nitric oxide synthase 1

multiple interactions

NOS1 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased ribosylation of Adenosine Diphosphate Ribose]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions
increases activity

Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]; Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein
2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]]; Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; Selenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; [Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein; Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; Glutathione inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]

PMID:18204483 PMID:20878536 PMID:21900507 PMID:22750002 PMID:33309544 More...

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

AMP-PNP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

Adenylyl Imidodiphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

CF transmembrane conductance regulator

affects activity

Adenylyl Imidodiphosphate affects the activity of CFTR protein

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

casein kinase 2 alpha 1

affects binding

Adenylyl Imidodiphosphate binds to CSNK2A1 protein

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

prostaglandin D2 receptor

multiple interactions

Adenylyl Imidodiphosphate inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

arachidonoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

peroxisome proliferator activated receptor alpha

multiple interactions

arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

ATP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 8

multiple interactions

Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988

G

ATP binding cassette subfamily B member 11

multiple interactions

Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
affects binding
increases hydrolysis

[Cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; [Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate; ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]
Adenosine Triphosphate binds to ABCB1 protein
[Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate

PMID:2900677 PMID:14978246 PMID:18829547 PMID:18955043 PMID:22233293 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

multiple interactions
affects activity
increases hydrolysis
affects binding

[Adenosine Triphosphate affects the activity of ABCC1 protein] which results in increased transport of Acetaminophen metabolite; ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate; ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; ABCC1 protein mutant form binds to and results in increased hydrolysis of Adenosine Triphosphate; Adenosine Triphosphate binds to and affects the folding of ABCC1 protein; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
Adenosine Triphosphate binds to ABCC1 protein

PMID:10856430 PMID:11278000 PMID:14978246 PMID:15245331 PMID:15355964 More...

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions
affects activity
affects metabolic processing

Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of temocaprilat]
Adenosine Triphosphate affects the activity of ABCC2 protein
[Adenosine Triphosphate affects the activity of ABCC2 protein] which results in increased transport of Acetaminophen metabolite; [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
ABCC2 protein affects the metabolism of Adenosine Triphosphate
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased transport of S-1,2-dichlorovinyl-N-acetylcysteine]

PMID:9067317 PMID:9794919 PMID:20060011 PMID:22027652 PMID:24039982 More...

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions

Adenosine Triphosphate promotes the reaction [ABCC3 protein affects the transport of fexofenadine]

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

multiple interactions
affects activity
increases hydrolysis

[Adenosine Triphosphate affects the activity of ABCC4 protein] which results in increased transport of Acetaminophen metabolite; ABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate; daidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; Resveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]; Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]

PMID:14978246 PMID:16156793 PMID:32472168

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 6

affects binding

Adenosine Triphosphate binds to ABCC6 protein

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily C member 8

multiple interactions

Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]

NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510

G

ATP binding cassette subfamily C member 9

multiple interactions

Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]
Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]

PMID:11390963 PMID:28842488

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ATP binding cassette subfamily G member 2

increases hydrolysis
multiple interactions

ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Lapatinib promotes the reaction [ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]

PMID:18829547 PMID:32003934

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions
increases chemical synthesis

[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]
ABL1 protein mutant form results in increased chemical synthesis of Adenosine Triphosphate

PMID:19366808 PMID:33070465

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acyl-CoA synthetase long-chain family member 5

multiple interactions

[ACSL5 protein affects the susceptibility to Palmitic Acid] which affects the abundance of Adenosine Triphosphate

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

actin alpha 2, smooth muscle

multiple interactions

3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ACTA2 mRNA]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ACTA2 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 mRNA]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

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adenylate cyclase activating polypeptide 1

increases secretion

ADCYAP1 protein results in increased secretion of Adenosine Triphosphate

NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773

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angiotensin II receptor, type 1a

multiple interactions
decreases expression

Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]; CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein]; Cyclosporine inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A protein]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

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aryl hydrocarbon receptor

multiple interactions

Adenosine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

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AKT serine/threonine kinase 1

decreases activity
multiple interactions

Adenosine Triphosphate results in decreased activity of AKT1 protein
Alcohols inhibits the reaction [Adenosine Triphosphate results in decreased activity of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

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aldehyde dehydrogenase 5 family, member A1

increases abundance

ALDH5A1 gene mutant form results in increased abundance of Adenosine Triphosphate

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

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ALK receptor tyrosine kinase

affects binding
multiple interactions

ALK protein binds to Adenosine Triphosphate
[ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib; ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

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alkaline phosphatase, biomineralization associated

increases response to substance
multiple interactions

ALPL gene mutant form results in increased susceptibility to Adenosine Triphosphate
ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

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annexin A1

multiple interactions

[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein; arsenite affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Cadmium affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; chromium hexavalent ion affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]; Lead affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

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amyloid beta precursor protein

multiple interactions
increases secretion

Adenosine Triphosphate inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]; Adenosine Triphosphate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form]; Rotenone inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

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arrestin, beta 2

multiple interactions

Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; ARRB2 protein affects the reaction [Adenosine Triphosphate results in decreased activity of AGTR1A protein]

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

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acid sensing ion channel subunit 1

multiple interactions

[Acids binds to and affects the activity of ASIC1 protein] which results in increased secretion of Adenosine Triphosphate

NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541

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acid sensing ion channel subunit 2

multiple interactions

[Acids binds to and affects the activity of ASIC2 protein] which results in increased secretion of Adenosine Triphosphate

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

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acid sensing ion channel subunit 3

multiple interactions

[Acids binds to and affects the activity of ASIC3 protein] which results in increased secretion of Adenosine Triphosphate

NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643

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ATPase copper transporting alpha

multiple interactions

[Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7A protein

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

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ATPase copper transporting beta

multiple interactions
increases phosphorylation

[Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7B protein
Adenosine Triphosphate results in increased phosphorylation of ATP7B protein

PMID:19405516 PMID:20964302

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

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ATPase phospholipid transporting 8B1

increases hydrolysis

ATP8B1 protein results in increased hydrolysis of Adenosine Triphosphate

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

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arginine vasopressin

multiple interactions
increases secretion

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein]

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

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BCL2, apoptosis regulator

multiple interactions

[Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

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BCR activator of RhoGEF and GTPase

multiple interactions

[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]

NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016

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baculoviral IAP repeat-containing 5

increases abundance

BIRC5 protein results in increased abundance of Adenosine Triphosphate

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

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calcineurin binding protein 1

multiple interactions

CABIN1 protein inhibits the reaction [Adenosine Triphosphate results in decreased expression of and results in decreased activity of AGTR1A protein]

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

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calcitonin-related polypeptide alpha

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of CALCA protein
Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]; Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]]

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

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caspase 1

increases activity
multiple interactions

Adenosine Triphosphate results in increased activity of CASP1 mRNA; Adenosine Triphosphate results in increased activity of CASP1 protein
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]
[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of and results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein; Acetylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]; fraxinellone inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of and results in increased cleavage of CASP1 protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP1 protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of CASP1 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein; [Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein modified form]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA]

PMID:18604214 PMID:19130485 PMID:21832250 PMID:23430110 PMID:24149798 More...

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

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caspase 3

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of CASP3
Adenosine Triphosphate inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]

PMID:19448140 PMID:24732427

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 4

multiple interactions

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of CASP4 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased secretion of and results in increased activity of CASP4 protein]
Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]

PMID:24149798 PMID:25288807

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

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catalase

increases expression

Adenosine Triphosphate results in increased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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C-C motif chemokine ligand 3

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of CCL3 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

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CF transmembrane conductance regulator

multiple interactions

3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]]; [Phosphatidylinositol 4,5-Diphosphate co-treated with Adenosine Triphosphate] results in increased activity of CFTR protein; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Adenosine Triphosphate binds to and results in increased activity of CFTR protein; Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]

PMID:14710196 PMID:15623556 PMID:17178710 PMID:20675434

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

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cysteine and histidine rich domain containing 1

multiple interactions

Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]
Adenosine Triphosphate binds to and affects the folding of CHORDC1 protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

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collagen type I alpha 1 chain

multiple interactions

3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA; [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; Adenosine Triphosphate promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of COL1A1 mRNA]; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of COL1A1 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 mRNA]; L 709049 inhibits the reaction [[[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of Biological Factors] which results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

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catechol-O-methyltransferase

multiple interactions

[Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

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carnitine palmitoyltransferase 2

multiple interactions

[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate]

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

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CRK like proto-oncogene, adaptor protein

multiple interactions

[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein; sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]; sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein]

NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238

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colony stimulating factor 2

multiple interactions

[CSF2 protein affects the susceptibility to stearic acid] which affects the abundance of Adenosine Triphosphate

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

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casein kinase 2 alpha 1

multiple interactions
affects binding

silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]]

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

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casein kinase 2 beta

multiple interactions
affects binding

silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]]

NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133

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cystatin B

multiple interactions

Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP1 protein]; Adenosine Triphosphate promotes the reaction [[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased cleavage of CASP4 protein]

NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526

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cathepsin B

increases activity
multiple interactions

Adenosine Triphosphate results in increased activity of CTSB protein
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of CTSB protein]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

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C-X-C motif chemokine ligand 2

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of CXCL2 protein
azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

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dystrophin

increases secretion
multiple interactions

DMD gene mutant form results in increased secretion of Adenosine Triphosphate
Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate]

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

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dual specificity phosphatase 1

multiple interactions

Adenosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP1 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP1 protein]]

NCBI chr10:16,680,478...16,683,275

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dual specificity phosphatase 6

multiple interactions

Adenosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of DUSP6 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in decreased expression of DUSP6 protein]]

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

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epidermal growth factor receptor

multiple interactions
increases phosphorylation

sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

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early growth response 1

multiple interactions
increases expression

Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of EGR1 mRNA]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleotide pyrophosphatase/phosphodiesterase 7

decreases activity

Adenosine Triphosphate results in decreased activity of ENPP7 protein

NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589

G

ERCC excision repair 6, chromatin remodeling factor

decreases abundance
multiple interactions

ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate
nicotinamide-beta-riboside inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Adenosine Triphosphate]

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

coagulation factor II, thrombin

multiple interactions
increases transport
increases abundance
increases secretion

2,4,3',5'-tetramethoxystilbene inhibits the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; [RWJ-56110 co-treated with 2,4,3',5'-tetramethoxystilbene] inhibits the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]; Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]; Resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]
F2 protein results in increased transport of Adenosine Triphosphate
STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate]

PMID:2030746 PMID:15342215 PMID:30696774 PMID:35288162

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fatty acid synthase

multiple interactions
decreases abundance

FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; Protein Kinase Inhibitors inhibits the reaction [FASN protein results in decreased abundance of Adenosine Triphosphate]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fructose-bisphosphatase 1

multiple interactions

[Enzyme Inhibitors results in decreased activity of FBP1 protein] which results in decreased abundance of Adenosine Triphosphate

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

F-box protein 3

multiple interactions

FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]

NCBI chr 3:90,417,262...90,449,557
Ensembl chr 3:90,417,297...90,449,557

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of FOS mRNA
ALPL gene mutant form promotes the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]
[Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; Glucose affects the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Iodoacetates inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Potassium Cyanide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]; Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased expression of FOS mRNA]

PMID:10723097 PMID:19463813 PMID:27466191

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

fascin actin-bundling protein 1

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of FSCN1 mRNA
Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA]

NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth hormone 1

multiple interactions
increases secretion

oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

gap junction protein, alpha 1

increases export

GJA1 protein mutant form results in increased export of Adenosine Triphosphate; GJA1 protein results in increased export of Adenosine Triphosphate

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gasdermin D

multiple interactions

[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of GSDMD protein; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]

PMID:33851234 PMID:34212273 PMID:34217685 PMID:35962723 PMID:36577999 More...

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glutathione S-transferase pi 1

multiple interactions

[GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H2A.X variant histone

multiple interactions

Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]; U 0126 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

HCK proto-oncogene, Src family tyrosine kinase

multiple interactions
affects binding

[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Adenosine Triphosphate inhibits the reaction [protoporphyrin IX results in decreased activity of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 1

multiple interactions

[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HK1 protein; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of CASP1 protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of GSDMD protein]]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HK1 protein]

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

multiple interactions

[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of HK2 mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of HK2 protein

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 1

affects chemical synthesis
multiple interactions

HMGB1 protein affects the chemical synthesis of Adenosine Triphosphate
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of MYD88 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of RELA protein; Adenosine Triphosphate promotes the reaction [fullerene C60 results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [graphene oxide results in increased secretion of HMGB1 protein]; Adenosine Triphosphate promotes the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of CASP1 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of MYD88 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of RELA protein]

PMID:21641551 PMID:31504961 PMID:34405489

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of HMOX1 protein; Luteolin promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein 90 alpha family class A member 1

multiple interactions

Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

affects chemical synthesis

HSPB1 protein affects the chemical synthesis of Adenosine Triphosphate

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

bisindolylmaleimide I inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; Neomycin inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; resveratrol inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein]

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

intercellular adhesion molecule 1

multiple interactions

Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 12B

multiple interactions

Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 18

multiple interactions
increases secretion

[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]
Adenosine Triphosphate results in increased secretion of IL18 protein
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL18 mRNA]

PMID:17404311 PMID:24149798 PMID:26431797 PMID:27311643 PMID:31993881 More...

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases secretion
decreases abundance

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein; Enzyme Inhibitors inhibits the reaction [IL1B protein results in decreased abundance of Adenosine Triphosphate]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; Quercetin inhibits the reaction [IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]]
Adenosine Triphosphate results in increased secretion of IL1B protein
(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of and results in increased secretion of IL1B protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of and affects the cleavage of IL1B protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; Okadaic Acid inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of IL1B mRNA]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of IL1B protein; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein; Adenosine Triphosphate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Adenosine Triphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; HK1 protein affects the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]; HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of IL1B protein]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL1B protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; L 709049 inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]

PMID:10365824 PMID:14623498 PMID:17404311 PMID:18604214 PMID:19130485 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

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interleukin 6

multiple interactions
increases expression

[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL6 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of IL6 protein]; NF157 compound inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]
Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; resveratrol inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]; SB 203580 inhibits the reaction [Adenosine Triphosphate promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased secretion of IL6 protein]]
[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL6 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of IL6 mRNA]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein]; MRS 2211 inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]

PMID:17707769 PMID:24793913 PMID:24849676 PMID:25348860 PMID:26104857 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

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insulin 1

multiple interactions
increases secretion

Adenosine Triphosphate inhibits the reaction [Glucose results in increased secretion of INS1 protein]
Adenosine Triphosphate results in increased secretion of INS1 protein
[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate; IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]; Quercetin inhibits the reaction [IL1B protein inhibits the reaction [Adenosine Triphosphate results in increased secretion of INS1 protein]]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]

PMID:10535451 PMID:10780946 PMID:16366736 PMID:22221676

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

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insulin 2

multiple interactions

[ammonium ferrous sulfate results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; INS protein inhibits the reaction [Acetaminophen results in decreased abundance of Adenosine Triphosphate]; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]

PMID:17965850 PMID:26739624

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

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interferon regulatory factor 2

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IRF2 mRNA; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IRF2 mRNA]

NCBI chr16:45,439,215...45,550,054
Ensembl chr16:45,439,225...45,550,024

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integrin subunit beta 1 binding protein 2

multiple interactions

Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]]
Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to CHORDC1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to ITGB1BP2 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to HSP90AA1 protein]]

NCBI chr X:66,572,537...66,577,174
Ensembl chr X:66,572,537...66,577,174

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Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

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potassium voltage-gated channel subfamily D member 2

multiple interactions
increases abundance

[[FAM66C mRNA binds to and results in decreased expression of MIR23 mRNA] which results in increased expression of KCND2 protein] which results in increased abundance of Adenosine Triphosphate; [[MIR23B mRNA binds to KCND2 3' UTR] which results in decreased expression of KCND2 protein] which results in decreased abundance of Adenosine Triphosphate
KCND2 protein results in increased abundance of Adenosine Triphosphate

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

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potassium voltage-gated channel subfamily H member 2

decreases activity

Adenosine Triphosphate deficiency results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

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potassium inwardly-rectifying channel, subfamily J, member 11

multiple interactions
decreases response to substance

Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]; Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]; Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
KCNJ11 protein mutant form results in decreased susceptibility to Adenosine Triphosphate

PMID:11390963 PMID:28842488

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

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potassium inwardly-rectifying channel, subfamily J, member 15

increases activity

Adenosine Triphosphate results in increased activity of KCNJ15 protein

NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952

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potassium inwardly-rectifying channel, subfamily J, member 8

multiple interactions
decreases response to substance

Adenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]
KCNJ8 protein mutant form results in decreased susceptibility to Adenosine Triphosphate

NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603

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ketohexokinase

multiple interactions

KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate]

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

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kinesin family member 5A

multiple interactions
increases hydrolysis

Adenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]; Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]; Egtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]]

PMID:24239783 PMID:28122263

NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858

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leptin

multiple interactions

[[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein; [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

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lipase E, hormone sensitive type

increases activity

Adenosine Triphosphate results in increased activity of LIPE protein

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

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lipoprotein lipase

affects response to substance

LPL protein affects the susceptibility to Adenosine Triphosphate

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

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mitogen activated protein kinase kinase 1

affects binding

Adenosine Triphosphate binds to MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

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mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK1 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK1 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK1 protein]]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK1 protein]

PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

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mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
increases activity

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; [Alcohols co-treated with Adenosine Triphosphate] results in increased activity of MAPK3 protein; Alcohols inhibits the reaction [Adenosine Triphosphate results in increased activity of MAPK3 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased phosphorylation of MAPK3 protein]]; sodium arsenite promotes the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of MAPK3 protein]

PMID:12513686 PMID:15034929 PMID:21503959 PMID:24300283 PMID:26104857 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

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microtubule-associated protein tau

multiple interactions

[annonacin results in decreased abundance of Adenosine Triphosphate] which affects the localization of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

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meteorin-like, glial cell differentiation regulator

multiple interactions

METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Adenosine Triphosphate]

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

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mitofusin 2

decreases response to substance
multiple interactions
increases chemical synthesis

MFN2 results in decreased susceptibility to Adenosine Triphosphate deficiency
MFN2 protein inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate]
MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]
MFN2 protein results in increased chemical synthesis of Adenosine Triphosphate

PMID:22292091 PMID:24898700 PMID:25416777

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

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microRNA 219a-1

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of MIR219A1 mRNA; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]]; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]

NCBI chr20:4,829,687...4,829,796
Ensembl chr20:4,829,687...4,829,796

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microRNA 23b

multiple interactions
decreases abundance

[[MIR23B mRNA binds to KCND2 3' UTR] which results in decreased expression of KCND2 protein] which results in decreased abundance of Adenosine Triphosphate
MIR23B mRNA results in decreased abundance of Adenosine Triphosphate

NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763

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matrix metallopeptidase 2

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP2 mRNA; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

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matrix metallopeptidase 9

multiple interactions
increases activity
increases secretion

1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; SB 3CT compound inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]; wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP9 mRNA; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of MMP9 mRNA]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of MMP9 protein]
Adenosine Triphosphate results in increased secretion of MMP9 protein

PMID:20195827 PMID:26522449 PMID:36847822

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

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mitochondrially encoded ATP synthase membrane subunit 6

affects abundance

ATP6 protein affects the abundance of Adenosine Triphosphate

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

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mitochondrially encoded cytochrome c oxidase III

increases abundance

COX3 protein results in increased abundance of Adenosine Triphosphate

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

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mevalonate diphosphate decarboxylase

increases hydrolysis

MVD protein results in increased hydrolysis of Adenosine Triphosphate

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

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mevalonate kinase

increases hydrolysis
multiple interactions

MVK protein results in increased hydrolysis of Adenosine Triphosphate
3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; dolichol monophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

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MYD88, innate immune signal transduction adaptor

multiple interactions

[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of MYD88 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of MYD88 protein; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of MYD88 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of MYD88 protein]

PMID:34405489 PMID:37544346

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

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myosin heavy chain 7

increases abundance

MYH7 gene mutant form results in increased abundance of Adenosine Triphosphate

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

NAD synthetase 1

multiple interactions

[Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased activity of NADSYN1 protein; [NADSYN1 protein co-treated with Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased chemical synthesis of NAD

NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869

G

neuronal calcium sensor 1

multiple interactions
increases response to substance

NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]
NCS1 protein results in increased susceptibility to Adenosine Triphosphate

NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829

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nuclear factor of activated T-cells 1

affects localization
multiple interactions

Adenosine Triphosphate affects the localization of NFATC1 protein
azetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein]

PMID:21464294 PMID:26522449

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

nuclear factor of activated T-cells 3

affects localization

Adenosine Triphosphate affects the localization of NFATC3 protein

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

NFE2 like bZIP transcription factor 2

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] affects the localization of NFE2L2 protein; Luteolin promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] affects the localization of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]
[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of NFKBIA protein]

PMID:21464294 PMID:24149798

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

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nerve growth factor

multiple interactions

[NGF protein co-treated with Adenosine Triphosphate] results in increased uptake of Calcium

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

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NLR family, pyrin domain containing 1A

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with resveratrol] results in increased expression of NLRP1 mRNA

NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180

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NLR family, pyrin domain containing 3

multiple interactions

[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 protein; [Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of NLRP3 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of NLRP3 protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 protein]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]
[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein; [Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with Resveratrol] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein; Acetylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]; KN 62 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]

PMID:18604214 PMID:23430110 PMID:24149798 PMID:26086368 PMID:26586371 More...

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

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nucleolar and coiled-body phosphoprotein 1

multiple interactions

Adenosine Triphosphate affects the reaction [Doxorubicin binds to NOLC1 protein]

NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088

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nitric oxide synthase 2

multiple interactions
increases expression

[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NOS2 protein; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NOS2 protein]
azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein]
[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein]; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased abundance of Nitric Oxide]

PMID:21464294 PMID:26522449 PMID:36847822

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

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nitric oxide synthase 3

multiple interactions

Adenosine Triphosphate affects the reaction [Alcohols affects the phosphorylation of NOS3 protein]; Adenosine Triphosphate inhibits the reaction [Alcohols results in decreased expression of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

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neuropeptide Y

affects response to substance

NPY protein affects the susceptibility to Adenosine Triphosphate

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

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nuclear receptor subfamily 4, group A, member 1

increases expression

Adenosine Triphosphate results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

2'-5' oligoadenylate synthetase 1A

multiple interactions

[OAS1 protein results in increased metabolism of Adenosine Triphosphate] which results in increased chemical synthesis of 2',5'-oligoadenylate

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

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oxytocin/neurophysin I prepropeptide

multiple interactions
increases secretion

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

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purinergic receptor P2X 1

multiple interactions
affects binding

geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]; monorden promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]
ATP binds to P2rx1 protein

CTD
RGD

PMID:11930156 PMID:12237343

NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623

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purinergic receptor P2X 2

multiple interactions
affects activity
increases activity
affects response to substance

1-amino-4-(3-(4,6-dichloro(1,3,5)triazine-2-ylamino)phenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Acetylcysteine inhibits the reaction [Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Cadmium Chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cobaltous chloride affects the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Copper promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; cupric chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercuric Chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; methyl methanethiosulfonate inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; myxothiazol promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; nickel chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; palladium chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; zinc chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]
ATP affects activity of rat P2x2 receptor in transfected glial cells
P2RX2 protein affects the susceptibility to Adenosine Triphosphate

CTD
RGD

PMID:15081800 PMID:16190872 PMID:19793987 PMID:21207957 PMID:16388598

NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891

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purinergic receptor P2X 3

multiple interactions
increases activity
affects activity

Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate]
Adenosine Triphosphate results in increased activity of P2RX3 protein

PMID:19967073 PMID:27481062

NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178

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purinergic receptor P2X 4

multiple interactions
increases activity

[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cadmium promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Cobalt promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]; Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
5-(3-bromophenyl)-1,3-dihydro-2H-benzofuro(3,2-e)-1,4-diazepin-2-one inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; [ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA; [Resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein; ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; ginsenoside Rd promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

PMID:10737610 PMID:15629187 PMID:19793987 PMID:21638035 PMID:24149798 More...

NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253

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purinergic receptor P2X 5

affects transport

ATP affects transport ion flux of P2rx5 receptor

RGD

NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423

G

purinergic receptor P2X 7

multiple interactions
increases response to substance
increases expression
decreases response to substance
increases activity

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA; [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein; Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein; AZ 11645373 inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; calmidazolium inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]; KN 62 inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]; P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 mRNA]; Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX7 protein]; ZINC58368839 inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]
P2RX7 protein results in increased susceptibility to Adenosine Triphosphate
Adenosine Triphosphate results in increased expression of P2RX7 protein
P2RX7 gene mutant form results in decreased susceptibility to Adenosine Triphosphate
3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein]; coomassie Brilliant Blue inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]

PMID:11003599 PMID:17728465 PMID:19023039 PMID:21638035 PMID:23565201 More...

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

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purinergic receptor P2Y1

multiple interactions
affects activity

[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium]
[N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]
Adenosine Triphosphate affects the activity of P2RY1 protein

PMID:12694404 PMID:15243297 PMID:16973929 PMID:22129738

NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457

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purinergic receptor P2Y13

multiple interactions

MRS 2211 inhibits the reaction [P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]

NCBI chr 2:143,470,437...143,476,360
Ensembl chr 2:143,470,425...143,473,434

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purinergic receptor P2Y2

multiple interactions
affects activity
increases activity

[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Calcium
[Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased uptake of Calcium
Adenosine Triphosphate affects the activity of P2RY2 protein

PMID:11527950 PMID:15243297 PMID:17003265

NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632

G

pyrimidinergic receptor P2Y4

multiple interactions

[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium; Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein; Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium]

NCBI chr X:65,681,680...65,717,404
Ensembl chr X:65,683,232...65,721,748

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pyrimidinergic receptor P2Y6

multiple interactions

N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]; P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]

NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808

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Pannexin 1

decreases activity
multiple interactions
increases export

Adenosine Triphosphate results in decreased activity of PANX1 protein
Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]; Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]

PMID:19023039 PMID:19213873

NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774

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poly (ADP-ribose) polymerase 1

multiple interactions
increases expression

PARP1 mutant form inhibits the reaction [Cadmium results in decreased abundance of Adenosine Triphosphate]
PARP1 protein affects the reaction [pyrithione zinc results in decreased abundance of Adenosine Triphosphate]; PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate]
Adenosine Triphosphate results in increased expression of PARP1 protein

PMID:17728843 PMID:19809895 PMID:21767558 PMID:22253048

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

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pyruvate dehydrogenase kinase 1

multiple interactions
affects response to substance

[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium; Adenosine Triphosphate promotes the reaction [PDK1 protein affects the abundance of Calcium]; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Adenosine Triphosphate] which affects the abundance of Calcium]

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

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phosphofructokinase, muscle

multiple interactions

Adenosine Triphosphate promotes the reaction [resveratrol results in decreased activity of PFKM protein]

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

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phosphoglycolate phosphatase

decreases phosphorylation

PGP protein results in decreased phosphorylation of Adenosine Triphosphate

NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858

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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions
affects binding

2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Adenosine Triphosphate binds to PIK3CA protein]; Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]

PMID:17550345 PMID:18754654

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

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phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

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phospholipase A2 group IVA

increases activity

Adenosine Triphosphate results in increased activity of PLA2G4A protein

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

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plasminogen activator, urokinase

increases secretion

Adenosine Triphosphate results in increased secretion of PLAU protein

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

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phospholipid phosphatase 3

decreases chemical synthesis

PLPP3 gene mutant form results in decreased chemical synthesis of Adenosine Triphosphate

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

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PML nuclear body scaffold

multiple interactions

[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PML protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [PML protein binds to CASP1 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PML protein; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to CASP1 protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased abundance of Reactive Oxygen Species]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; PML protein promotes the reaction [[resiquimod co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

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phosphomevalonate kinase

increases hydrolysis

PMVK protein results in increased hydrolysis of Adenosine Triphosphate

NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Fenofibrate results in increased activity of PPARA protein] which results in decreased abundance of Adenosine Triphosphate

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

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peroxisome proliferator-activated receptor gamma

multiple interactions
decreases abundance

FASN protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]; rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]
PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate; PPARG protein results in decreased abundance of Adenosine Triphosphate

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

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protein phosphatase 5, catalytic subunit

multiple interactions

Adenosine Triphosphate binds to and affects the folding of PPP5C protein; Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein]

NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456

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peroxiredoxin 2

increases expression

Adenosine Triphosphate results in increased expression of PRDX2 protein modified form

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

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protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

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protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Glucose co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

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protein kinase C, alpha

multiple interactions

[[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

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prostaglandin-endoperoxide synthase 2

multiple interactions

[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein; resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in decreased expression of PYCARD mRNA]
[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to PYCARD protein]; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to PYCARD protein]]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased expression of PYCARD protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] promotes the reaction [NLRP3 protein binds to PYCARD protein]]; PYCARD gene mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of G(M3) Ganglioside]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of and results in increased cleavage of IL1B protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of PYCARD protein]

PMID:18604214 PMID:23430110 PMID:24149798 PMID:24475307 PMID:32721574 More...

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

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ralA binding protein 1

multiple interactions

[[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin; Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4]

PMID:15386349 PMID:16087181

NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707

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RELA proto-oncogene, NF-kB subunit

multiple interactions

[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]; Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to ARRB2 protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NFKBIA protein]]; ARRB2 affects the reaction [Adenosine Triphosphate promotes the reaction [RELA protein binds to NOS2 protein]]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]
[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of RELA protein; [Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RELA protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased phosphorylation of RELA protein; [mitochondrial uncoupler BAM15 co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RELA protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased phosphorylation of RELA protein]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased phosphorylation of RELA protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased phosphorylation of RELA protein]
[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased phosphorylation of and affects the localization of RELA protein; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased phosphorylation of and affects the localization of RELA protein]; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]; Resveratrol promotes the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] affects the localization of RELA protein]; S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein]

PMID:21464294 PMID:24149798 PMID:33524445 PMID:34217685 PMID:34405489 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

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ras homolog family member F, filopodia associated

multiple interactions
increases expression

Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA]

NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703

G

S100 calcium binding protein A10

increases expression

Adenosine Triphosphate results in increased expression of S100A10 mRNA

NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661

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S100 calcium binding protein A11

increases expression

Adenosine Triphosphate results in increased expression of S100A11 mRNA

NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044

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S100 calcium-binding protein A4

multiple interactions
increases expression

Adenosine Triphosphate results in increased expression of and results in increased secretion of S100A4 protein; Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of S100A4 protein]
Adenosine Triphosphate results in increased expression of S100A4 mRNA

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

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S100 calcium binding protein A6

increases expression

Adenosine Triphosphate results in increased expression of S100A6 mRNA

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

selectin L

multiple interactions

P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

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surfactant protein A1

multiple interactions

[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]

NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685

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surfactant protein B

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of SFTPB protein
Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]

PMID:11704537 PMID:14565945

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

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surfactant protein C

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of SFTPC protein
Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]

PMID:11704537 PMID:14565945

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

sirtuin 1

multiple interactions

[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]; SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein]; SIRT1 protein promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]
[STK11 protein co-treated with Adenosine Triphosphate] results in increased activity of and results in increased phosphorylation of SIRT1 protein

PMID:16366736 PMID:34216621

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

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sirtuin 3

multiple interactions

SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 25 member 14

decreases chemical synthesis

SLC25A14 protein results in decreased chemical synthesis of Adenosine Triphosphate

NCBI chr X:127,807,630...127,845,823
Ensembl chr X:127,807,449...127,845,823

G

solute carrier family 2 member 1

decreases stability

Adenosine Triphosphate results in decreased stability of SLC2A1 protein

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

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solute carrier family 2 member 4

increases abundance

SLC2A4 protein results in increased abundance of Adenosine Triphosphate

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 46 member 1

multiple interactions

[SLC46A1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid] which results in decreased chemical synthesis of Adenosine Triphosphate

NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848

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solute carrier family 5 member 5

multiple interactions

Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein]

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

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synuclein alpha

multiple interactions
decreases abundance

GW8510 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]; SB 216763 inhibits the reaction [SNCA protein results in decreased abundance of Adenosine Triphosphate]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

superoxide dismutase 1

increases expression

Adenosine Triphosphate results in increased expression of SOD1 protein

PMID:16178011 PMID:22129738

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

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superoxide dismutase 2

affects chemical synthesis
decreases abundance
multiple interactions

SOD2 protein affects the chemical synthesis of Adenosine Triphosphate
SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate
MK-886 promotes the reaction [SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate]

PMID:20638473 PMID:25362851

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

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serine racemase

multiple interactions

Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Adenosine Triphosphate promotes the reaction [SRR protein results in increased abundance of D-Aspartic Acid]

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

serine/threonine kinase 11

multiple interactions

[STK11 protein co-treated with Adenosine Triphosphate] results in increased activity of and results in increased phosphorylation of SIRT1 protein

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

syntaxin binding protein 2

multiple interactions

STXBP2 protein affects the reaction [F2 protein results in increased transport of Adenosine Triphosphate]

NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458

G

SGT1 homolog, MIS12 kinetochore complex assembly cochaperone

multiple interactions

Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein]; Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]; Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]]

NCBI chr15:54,991,419...55,032,244
Ensembl chr15:54,990,672...55,069,150

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synapsin II

multiple interactions

SYN2 mutant form inhibits the reaction [Adenosine Triphosphate results in increased abundance of Calcium]

NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192

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tachykinin, precursor 1

increases secretion
multiple interactions

Adenosine Triphosphate results in increased secretion of TAC1 protein
Iloprost promotes the reaction [Adenosine Triphosphate results in increased secretion of TAC1 protein]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

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transaldolase 1

increases abundance

TALDO1 gene mutant form results in increased abundance of Adenosine Triphosphate

NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974

G

taste receptor, type 2, member 145

increases activity

Adenosine Triphosphate results in increased activity of TAS2R131 protein

NCBI chr 4:166,138,007...166,138,957
Ensembl chr 4:166,138,007...166,138,957

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transforming growth factor, beta 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased abundance of Adenosine Triphosphate

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

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translocase of inner mitochondrial membrane 17A

multiple interactions
decreases expression

1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein]

NCBI chr13:46,731,117...46,742,604
Ensembl chr13:46,730,660...46,742,655

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TIMP metallopeptidase inhibitor 1

decreases secretion
multiple interactions

Adenosine Triphosphate results in decreased secretion of TIMP1 protein
azetidine analog inhibits the reaction [Adenosine Triphosphate results in decreased secretion of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

toll-like receptor 4

multiple interactions

[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA; [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of TLR4 protein; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of TLR4 protein]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]; sodium houttuyfonate inhibits the reaction [[Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of TLR4 protein]

PMID:34405489 PMID:37544346

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

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tumor necrosis factor

multiple interactions
decreases chemical synthesis

[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of TNF mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of TNF protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Chlorides]; Adenosine Triphosphate deficiency inhibits the reaction [TNF protein results in increased transport of Potassium]; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased secretion of TNF protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased expression of TNF mRNA]; fuzheng huayu inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; mitochondrial uncoupler BAM15 inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]
TNF protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate]
TNF protein results in decreased chemical synthesis of Adenosine Triphosphate
[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein; [Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein]; MFN2 protein inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Rosiglitazone inhibits the reaction [TNF protein results in decreased chemical synthesis of Adenosine Triphosphate]; Vitamin K 3 promotes the reaction [[Asbestos, Amosite co-treated with TNF protein] results in increased metabolism of Adenosine Triphosphate]

PMID:8817062 PMID:10783394 PMID:14623498 PMID:17707769 PMID:23430110 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

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TNF superfamily member 11

increases abundance

TNFSF11 protein results in increased abundance of Adenosine Triphosphate

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

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DNA topoisomerase II alpha

multiple interactions
increases hydrolysis

Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; copper-thiosemicarbazone complex analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]]; Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Thiosemicarbazones analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]
TOP2A protein results in increased hydrolysis of Adenosine Triphosphate; TOP2A results in increased hydrolysis of Adenosine Triphosphate

PMID:20855424 PMID:26982206 PMID:27533850 PMID:29272108

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

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DNA topoisomerase II beta

increases hydrolysis
multiple interactions

TOP2B protein results in increased hydrolysis of Adenosine Triphosphate
cannabidiol hydroxyquinone inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate]; Cannabidiol metabolite inhibits the reaction [TOP2B protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

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tumor protein p53

multiple interactions
increases abundance

TP53 protein inhibits the reaction [Deoxyglucose results in decreased abundance of Adenosine Triphosphate]
TP53 gene mutant form results in increased abundance of Adenosine Triphosphate

PMID:21042727 PMID:33070465

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

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tumor protein p53 binding protein 1

multiple interactions

Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]; AZ10606120 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]; U 0126 inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

G

transient receptor potential cation channel, subfamily C, member 3

multiple interactions
increases activity

ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Adenosine Triphosphate results in increased activity of TRPC3 protein]

NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855

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transient receptor potential cation channel, subfamily C, member 5

increases activity

Adenosine Triphosphate results in increased activity of TRPC5 protein

NCBI chr X:107,946,163...108,230,991
Ensembl chr X:107,939,131...108,230,991

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transient receptor potential cation channel, subfamily C, member 6

increases activity

Adenosine Triphosphate results in increased activity of TRPC6 protein

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

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transient receptor potential cation channel, subfamily C, member 7

increases activity

Adenosine Triphosphate results in increased activity of TRPC7 protein

NCBI chr17:7,708,911...7,833,435
Ensembl chr17:7,709,583...7,833,435

G

transient receptor potential cation channel, subfamily M, member 4

decreases activity

Adenosine Triphosphate results in decreased activity of TRPM4 protein

PMID:16966582 PMID:17188667

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

[Capsaicin binds to and affects the activity of TRPV1 protein] which results in increased secretion of Adenosine Triphosphate

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

thyroid stimulating hormone subunit beta

multiple interactions

Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein]

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

G

thioredoxin 1

increases expression

Adenosine Triphosphate results in increased expression of TXN protein

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin interacting protein

increases activity

Adenosine Triphosphate results in increased activity of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

uncoupling protein 1

multiple interactions
decreases abundance

Adenosine Triphosphate inhibits the reaction [UCP1 protein results in increased transport of Protons]
UCP1 results in decreased abundance of Adenosine Triphosphate
UCP1 protein promotes the reaction [PPARG protein mutant form results in decreased abundance of Adenosine Triphosphate]; UCP1 protein promotes the reaction [rosiglitazone promotes the reaction [PPARG protein results in decreased abundance of Adenosine Triphosphate]]

PMID:12734183 PMID:26670611

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

uncoupling protein 2

multiple interactions

Adenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons]
[SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate]

PMID:12734183 PMID:16366736

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

uncoupling protein 3

multiple interactions

Adenosine Triphosphate inhibits the reaction [UCP3 protein results in increased transport of Protons]

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

voltage-dependent anion channel 1

multiple interactions

VDAC1 mutant form inhibits the reaction [chromium hexavalent ion results in decreased abundance of Adenosine Triphosphate]

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

X-ray repair cross complementing 1

multiple interactions
increases abundance
decreases abundance

Acetylcysteine inhibits the reaction [XRCC1 gene mutant form results in decreased abundance of Adenosine Triphosphate]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased abundance of Adenosine Triphosphate]

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

butyryl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

lysine acetyltransferase 2B

affects binding

butyryl-coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

cangrelor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coagulation factor III, tissue factor

multiple interactions

cangrelor results in decreased expression of and results in decreased activity of F3 protein; Indomethacin promotes the reaction [cangrelor results in decreased expression of and results in decreased activity of F3 protein]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

G protein-coupled receptor 17

multiple interactions

cangrelor inhibits the reaction [Uridine Diphosphate results in increased activity of GPR17 protein]

NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966

G

integrin subunit alpha 2b

multiple interactions

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]

NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168

G

integrin subunit beta 3

multiple interactions

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

purinergic receptor P2Y12

multiple interactions
affects response to substance
decreases activity

[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased abundance of phosphatidylinositol 3,4,5-triphosphate; [cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased phosphorylation of SYK protein
P2RY12 gene polymorphism affects the susceptibility to cangrelor
cangrelor results in decreased activity of P2RY12 protein

PMID:12606772 PMID:20126830 PMID:22273509

NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361

G

platelet factor 4

multiple interactions

cangrelor inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein]

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

selectin P

multiple interactions

cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]; N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

spleen associated tyrosine kinase

multiple interactions

[cangrelor binds to and results in decreased activity of P2RY12 protein] which results in decreased phosphorylation of SYK protein

NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410

CGS-21680

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase 5

increases response to substance
multiple interactions

ADCY5 protein results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
ADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

adenosine A2a receptor

increases response to substance
multiple interactions

ADORA2A protein results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; PRKCZ protein affects the reaction [[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein] which results in decreased expression of VEGFA mRNA]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]

PMID:11172060 PMID:12590138 PMID:15452191 PMID:19749167 PMID:19966059 More...

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

brain-derived neurotrophic factor

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of BDNF mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

basic helix-loop-helix ARNT like 1

increases expression
multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of BMAL1 mRNA
[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with TNF protein] results in increased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

clock circadian regulator

increases expression

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of CLOCK mRNA

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

collagen type III alpha 1 chain

increases expression
multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of COL3A1 protein
CTNNB1 protein affects the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of COL3A1 protein]

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

cAMP responsive element binding protein 1

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of CREB1 mRNA]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

catenin beta 1

affects localization
multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine affects the localization of CTNNB1 protein modified form
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of and affects the phosphorylation of CTNNB1 protein; CTNNB1 protein affects the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of COL3A1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 27, subfamily a, polypeptide 1

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of CYP27A1 protein]

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

epoxide hydrolase 2

multiple interactions
increases response to substance
decreases response to substance

12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [EPHX2 gene results in decreased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]; 14,15-eicosa-5-enoic acid inhibits the reaction [EPHX2 gene mutant form results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]; 4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [EPHX2 gene results in decreased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]; T 0070907 inhibits the reaction [EPHX2 gene mutant form results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

interleukin 10

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [TNF protein results in increased expression of IL10 mRNA]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

multiple interactions

[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with TNF protein] results in decreased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

leptin

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

matrix metallopeptidase 14

decreases activity

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased activity of MMP14 protein

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

decreases activity

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases activity
decreases expression

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased activity of MMP9 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

natriuretic peptide A

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]

PMID:15452191 PMID:19966059

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

nuclear receptor subfamily 1, group D, member 1

increases expression

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
increases expression

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of NTRK2 mRNA]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

period circadian regulator 2

decreases expression

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

protein kinase C, epsilon

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine affects the localization of and results in increased activity of PRKCE protein

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein kinase C, zeta

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine affects the localization of and results in increased activity of PRKCZ protein; PRKCZ protein affects the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased expression of VEGFA mRNA]; PRKCZ protein affects the reaction [[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein] which results in decreased expression of VEGFA mRNA]

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

renin

multiple interactions
increases expression

Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

regulator of G-protein signaling 2

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

sirtuin 1

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 3

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]]

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 9 member A1

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

SMAD family member 3

multiple interactions

8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

suppressor of cytokine signaling 3

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of SOCS3 mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [Oxygen deficiency results in increased expression of SOCS3 protein]

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

sterol regulatory element binding transcription factor 2

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

tumor necrosis factor

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine promotes the reaction [TNF protein results in increased expression of IL10 mRNA]; [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with TNF protein] results in decreased expression of IL12A mRNA; [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with TNF protein] results in increased expression of BMAL1 mRNA

PMID:21538184 PMID:22923002

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor A

increases secretion
decreases expression
multiple interactions

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased secretion of VEGFA protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased expression of VEGFA mRNA
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; PRKCZ protein affects the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased expression of VEGFA mRNA]; PRKCZ protein affects the reaction [[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein] which results in decreased expression of VEGFA mRNA]

PMID:12590138 PMID:20067761

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

clofarabine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acidic nuclear phosphoprotein 32 family member B

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of ANP32B protein

NCBI chr 5:60,743,077...60,765,726
Ensembl chr 5:60,743,443...60,765,717

G

ATM serine/threonine kinase

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

Bcl2-like 1

multiple interactions

[clofarabine co-treated with resveratrol] inhibits the reaction [BCL2L1 mutant form results in increased expression of MCL1 protein]; [clofarabine co-treated with resveratrol] promotes the reaction [BCL2L1 mutant form results in increased activity of CASP3 protein]; [clofarabine co-treated with resveratrol] promotes the reaction [BCL2L1 mutant form results in increased activity of CASP7 protein]; [clofarabine co-treated with resveratrol] promotes the reaction [BCL2L1 mutant form results in increased cleavage of CASP3 protein]; BCL2L1 protein affects the reaction [[clofarabine co-treated with resveratrol] results in increased activity of CASP3 protein]; BCL2L1 protein affects the reaction [[clofarabine co-treated with resveratrol] results in increased activity of CASP7 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

caspase 3

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP3 protein; [clofarabine co-treated with resveratrol] promotes the reaction [BCL2L1 mutant form results in increased activity of CASP3 protein]; [clofarabine co-treated with resveratrol] promotes the reaction [BCL2L1 mutant form results in increased cleavage of CASP3 protein]; [clofarabine co-treated with resveratrol] results in increased activity of CASP3 protein; [resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP3 protein]; [resveratrol co-treated with clofarabine] results in increased cleavage of and results in increased activity of CASP3 protein; [resveratrol co-treated with clofarabine] results in increased expression of CASP3 protein modified form; BCL2L1 protein affects the reaction [[clofarabine co-treated with resveratrol] results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[resveratrol co-treated with clofarabine] results in increased activity of CASP3 protein]; MCL1 mutant form promotes the reaction [[resveratrol co-treated with clofarabine] results in increased cleavage of CASP3 protein]

PMID:20933509 PMID:24239893 PMID:24924397 PMID:25408576

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 7

multiple interactions

[clofarabine co-treated with resveratrol] promotes the reaction [BCL2L1 mutant form results in increased activity of CASP7 protein]; [clofarabine co-treated with resveratrol] results in increased activity of CASP7 protein; [resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP7 protein]; [resveratrol co-treated with clofarabine] results in increased activity of CASP7 protein; BCL2L1 protein affects the reaction [[clofarabine co-treated with resveratrol] results in increased activity of CASP7 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP7 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[resveratrol co-treated with clofarabine] results in increased activity of CASP7 protein]

PMID:24924397 PMID:25408576

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

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caspase 9

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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cyclin D1

multiple interactions

[resveratrol co-treated with clofarabine] results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cell division cycle 25B

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[resveratrol co-treated with clofarabine] results in decreased expression of CDKN1A protein]; [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of CDKN1A protein; [resveratrol co-treated with clofarabine] results in decreased expression of CDKN1A protein

PMID:20933509 PMID:23146690

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

checkpoint kinase 1

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK2 protein; [clofarabine co-treated with fludarabine] results in increased phosphorylation of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

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H2A.X variant histone

multiple interactions

[Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

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MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

[clofarabine co-treated with resveratrol] inhibits the reaction [BCL2L1 mutant form results in increased expression of MCL1 protein]; [resveratrol co-treated with clofarabine co-treated with Cycloheximide] results in decreased expression of MCL1 protein; [resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP3 protein]; [resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP7 protein]; [resveratrol co-treated with clofarabine] results in decreased expression of MCL1 protein; [resveratrol co-treated with clofarabine] results in increased expression of MCL1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [[resveratrol co-treated with clofarabine] promotes the reaction [MCL1 mutant form results in increased activity of CASP7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[resveratrol co-treated with clofarabine] results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [clofarabine promotes the reaction [resveratrol results in decreased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol promotes the reaction [clofarabine results in decreased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[resveratrol co-treated with clofarabine] results in increased expression of MCL1 protein]; clofarabine promotes the reaction [resveratrol results in decreased expression of MCL1 protein]; MCL1 mutant form promotes the reaction [[resveratrol co-treated with clofarabine] results in increased cleavage of CASP3 protein]; MCL1 mutant form promotes the reaction [[resveratrol co-treated with clofarabine] results in increased cleavage of PARP1 protein]; resveratrol promotes the reaction [clofarabine results in decreased expression of MCL1 protein]

PMID:24924397 PMID:25408576

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

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MET proto-oncogene, receptor tyrosine kinase

multiple interactions

[resveratrol co-treated with clofarabine] results in decreased expression of MET protein

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

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MYC proto-oncogene, bHLH transcription factor

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

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poly (ADP-ribose) polymerase 1

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased cleavage of PARP1 protein; [resveratrol co-treated with clofarabine] results in increased cleavage of PARP1 protein; [resveratrol co-treated with clofarabine] results in increased expression of PARP1 protein modified form; MCL1 mutant form promotes the reaction [[resveratrol co-treated with clofarabine] results in increased cleavage of PARP1 protein]

PMID:20933509 PMID:24239893 PMID:24924397

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

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structural maintenance of chromosomes 1A

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC1A protein

NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056

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structural maintenance of chromosomes 3

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of SMC3 protein

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

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Sp1 transcription factor

multiple interactions

[resveratrol co-treated with clofarabine] affects the localization of SP1 protein; [resveratrol co-treated with clofarabine] results in decreased expression of SP1 protein

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

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tumor protein p53

multiple interactions
affects activity

[resveratrol co-treated with clofarabine] affects the localization of TP53 protein modified form; [resveratrol co-treated with clofarabine] results in increased expression of and results in increased activity of TP53 protein modified form; TP53 protein affects the susceptibility to [resveratrol co-treated with clofarabine]
Clofarabine affects the activity of TP53 protein

PMID:24239893 PMID:35435491

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

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X-linked inhibitor of apoptosis

multiple interactions

[clofarabine co-treated with fludarabine co-treated with Busulfan] results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

coenzyme A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 8

affects hydrolysis

ACOT8 protein affects the hydrolysis of Coenzyme A analog

NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851

G

lysine acetyltransferase 2B

affects binding

Coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

cordycepin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

decreases expression

cordycepin results in decreased expression of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

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acetylcholinesterase

multiple interactions

1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]]; cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

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actin alpha 2, smooth muscle

multiple interactions

cordycepin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

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actin-like 10

increases expression

cordycepin results in increased expression of ACTL10 mRNA

NCBI chr 3:143,057,061...143,058,561
Ensembl chr 3:143,057,402...143,058,442

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ADAM metallopeptidase domain 17

decreases expression
multiple interactions

cordycepin results in decreased expression of ADAM17 protein
cordycepin inhibits the reaction [Cycloheximide results in decreased stability of ADAM17 protein]

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

adenosine A2a receptor

multiple interactions

ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

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angiotensinogen

multiple interactions

cordycepin inhibits the reaction [AGT protein results in increased expression of IL1B protein]; cordycepin inhibits the reaction [AGT protein results in increased expression of IL6 protein]; cordycepin inhibits the reaction [AGT protein results in increased expression of KDR protein]; cordycepin inhibits the reaction [AGT protein results in increased expression of NOS3 protein]; cordycepin inhibits the reaction [AGT protein results in increased expression of PECAM1 protein]; cordycepin inhibits the reaction [AGT protein results in increased expression of TNF protein]; cordycepin inhibits the reaction [AGT protein results in increased expression of VEGFA protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

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AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

cordycepin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; cordycepin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; dorsomorphin inhibits the reaction [cordycepin results in decreased phosphorylation of AKT1 protein]
cordycepin results in increased phosphorylation of AKT1 protein
cordycepin inhibits the reaction [testosterone enanthate results in increased phosphorylation of AKT1 protein]; cordycepin results in increased expression of and results in increased phosphorylation of AKT1 protein

PMID:16899239 PMID:19940154 PMID:33948356 PMID:35196519 PMID:36015278

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

cordycepin inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased activity of ALPL protein]]
cordycepin results in increased expression of ALPL protein

PMID:32042022 PMID:34575692

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

adaptor related protein complex 1 subunit mu 2

increases expression

cordycepin results in increased expression of AP1M2 mRNA

NCBI chr 8:19,838,579...19,856,560
Ensembl chr 8:19,838,580...19,856,482

G

apolipoprotein E

increases expression

cordycepin results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein H

affects expression

cordycepin affects the expression of APOH mRNA

NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329

G

amyloid beta precursor protein

multiple interactions

1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]]; cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]; cordycepin inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPT protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 5

multiple interactions
increases expression

cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of AQP5 mRNA]
cordycepin results in increased expression of AQP5 mRNA

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

activating transcription factor 3

increases expression

cordycepin results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

autophagy related 12

affects expression

cordycepin affects the expression of ATG12 mRNA

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 5

increases expression

cordycepin results in increased expression of ATG5 mRNA

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

BCL2-associated agonist of cell death

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
affects localization

[cordycepin co-treated with apatinib] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAX protein]
cordycepin inhibits the reaction [testosterone enanthate results in decreased expression of BAX mRNA]; cordycepin inhibits the reaction [testosterone enanthate results in decreased expression of BAX protein]
[cordycepin results in increased expression of FOXO3 protein] which results in increased expression of BAX protein; cordycepin results in increased expression of BAX mRNA; cordycepin results in increased expression of BAX protein
cordycepin affects the localization of BAX protein

PMID:21310227 PMID:21933677 PMID:28099944 PMID:28987792 PMID:33014856 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

cordycepin results in decreased expression of BCL2 mRNA; cordycepin results in decreased expression of BCL2 protein
cordycepin inhibits the reaction [testosterone enanthate results in increased expression of BCL2 mRNA]; cordycepin inhibits the reaction [testosterone enanthate results in increased expression of BCL2 protein]
[cordycepin co-treated with apatinib] results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2 protein]

PMID:21310227 PMID:28987792 PMID:30529626 PMID:33014856 PMID:36015278

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

affects expression

cordycepin affects the expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCL3, transcription coactivator

multiple interactions

cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL3 mRNA]

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

bone gamma-carboxyglutamate protein

multiple interactions

cordycepin inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]]

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

BH3 interacting domain death agonist

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BID protein]

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

decreases expression

cordycepin results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 2

affects expression

cordycepin affects the expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

increases expression
multiple interactions

cordycepin results in increased expression of BMP4 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [cordycepin results in increased expression of BMP4 mRNA]; PSB603 inhibits the reaction [cordycepin results in increased expression of BMP4 mRNA]; ZM 241385 inhibits the reaction [cordycepin results in increased expression of BMP4 mRNA]

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

basigin (Ok blood group)

decreases expression

cordycepin results in decreased expression of BSG protein

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

cordycepin results in increased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

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similar to human chromosome 16 open reading frame 46

decreases expression

cordycepin results in decreased expression of C16ORF46 mRNA

NCBI chr19:45,017,499...45,033,453
Ensembl chr19:45,022,280...45,032,683

G

caspase 1

multiple interactions
increases cleavage

cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased expression of and results in increased activity of CASP1 protein]
cordycepin results in increased cleavage of CASP1 protein

PMID:23941773 PMID:30183461

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

increases cleavage

cordycepin results in increased cleavage of CASP12 protein

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

[cordycepin co-treated with apatinib] results in decreased expression of CASP3 protein; [cordycepin co-treated with apatinib] results in increased cleavage of CASP3 protein; [Doxorubicin co-treated with cordycepin] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP3 protein]; cordycepin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]
cordycepin inhibits the reaction [Calcium Chloride results in increased cleavage of CASP3 protein]
cordycepin inhibits the reaction [FGF9 protein results in decreased cleavage of CASP3 protein]; cordycepin results in increased cleavage of and results in increased activity of CASP3 protein
cordycepin results in increased cleavage of CASP3 protein
cordycepin results in increased expression of CASP3 mRNA

PMID:21310227 PMID:21933677 PMID:23941773 PMID:26303320 PMID:28099944 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
increases cleavage

acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases expression
increases activity

Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein]
cordycepin results in increased expression of CASP8 protein

PMID:21310227 PMID:23941773

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage
increases expression
increases activity

Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP9 protein]
cordycepin results in increased cleavage of CASP9 protein
cordycepin inhibits the reaction [Calcium Chloride results in increased cleavage of CASP9 protein]
cordycepin results in increased expression of CASP9 mRNA

PMID:21310227 PMID:21933677 PMID:28987792 PMID:35732609 PMID:36731150

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression
increases expression
multiple interactions

cordycepin results in decreased expression of CAT mRNA
cordycepin results in increased expression of CAT mRNA
cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT protein]

PMID:28987792 PMID:32714076 PMID:35196519

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions
increases expression
affects expression

[[cordycepin results in increased expression of CAV1 protein] which results in decreased expression of DUSP5 protein] which results in increased phosphorylation of MAPK8 protein
cordycepin affects the expression of CAV1 mRNA; cordycepin affects the expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 17

multiple interactions

cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased expression of CCL17 mRNA]

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

cyclin A1

multiple interactions

cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCNA1 protein]

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin B1

multiple interactions

cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCNB1 protein]

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression

cordycepin results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

multiple interactions
increases expression
decreases expression

cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCND1 protein]
[Cisplatin co-treated with cordycepin] results in decreased expression of CCND1 protein
cordycepin inhibits the reaction [testosterone enanthate results in increased expression of CCND1 protein]
cordycepin results in increased expression of CCND1 mRNA
cordycepin results in decreased expression of CCND1 protein

PMID:22366198 PMID:33172093 PMID:33520990 PMID:34070360 PMID:36015278

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

multiple interactions
decreases expression

cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCNE1 protein]
cordycepin results in decreased expression of CCNE1 protein

PMID:22366198 PMID:33172093

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

C-C motif chemokine receptor 3

multiple interactions

cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased expression of CCR3 mRNA]

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

cadherin 1

multiple interactions
decreases expression
increases expression

[Doxorubicin co-treated with cordycepin] results in increased expression of CDH1 protein; thymoquinone promotes the reaction [cordycepin results in increased expression of CDH1 protein]
cordycepin results in decreased expression of CDH1 protein

PMID:35186504 PMID:35732609 PMID:35774120

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions
decreases expression

[Doxorubicin co-treated with cordycepin] results in decreased expression of CDH2 protein; thymoquinone promotes the reaction [cordycepin results in decreased expression of CDH2 protein]

PMID:35186504 PMID:35774120

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

multiple interactions

cordycepin inhibits the reaction [FGF9 protein results in increased expression of CDK1 protein]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression
multiple interactions

cordycepin results in decreased expression of CDK2 protein
cordycepin promotes the reaction [CDK2 protein binds to CDKN1B protein]; HRAS protein mutant form inhibits the reaction [cordycepin results in increased expression of CDK2 protein]; MAPK3 protein affects the reaction [cordycepin results in decreased expression of CDK2 protein]; U 0126 inhibits the reaction [cordycepin results in decreased expression of CDK2 protein]
cordycepin inhibits the reaction [FGF9 protein results in increased expression of CDK2 protein]

PMID:22366198 PMID:26303320 PMID:33172093

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases expression
multiple interactions

cordycepin results in decreased expression of CDK4 protein
cordycepin inhibits the reaction [FGF9 protein results in increased expression of CDK4 protein]
cordycepin promotes the reaction [CDK4 protein binds to CDKN1B protein]; HRAS protein mutant form inhibits the reaction [cordycepin results in increased expression of CDK4 protein]; MAPK3 protein affects the reaction [cordycepin results in decreased expression of CDK4 protein]; U 0126 inhibits the reaction [cordycepin results in decreased expression of CDK4 protein]

PMID:22366198 PMID:33172093

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression
affects expression
increases expression

cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]
cordycepin results in decreased expression of CDKN1A mRNA
cordycepin affects the expression of CDKN1A mRNA
cordycepin results in decreased expression of CDKN1A protein
cordycepin results in increased expression of CDKN1A protein

PMID:19940154 PMID:23690541 PMID:26303320 PMID:28099944 PMID:33948356

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

cordycepin promotes the reaction [CDK2 protein binds to CDKN1B protein]; cordycepin promotes the reaction [CDK4 protein binds to CDKN1B protein]; HRAS protein mutant form inhibits the reaction [cordycepin results in increased expression of CDKN1B protein]; MAPK3 protein affects the reaction [cordycepin results in increased expression of CDKN1B protein]; U 0126 inhibits the reaction [cordycepin results in increased expression of CDKN1B protein]
cordycepin results in decreased expression of and results in decreased phosphorylation of CDKN1B protein

PMID:22366198 PMID:31145545

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

cordycepin results in decreased expression of and results in decreased phosphorylation of CDKN2B protein

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

CCAAT/enhancer binding protein alpha

multiple interactions

cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centrosomal protein 70

increases expression

cordycepin results in increased expression of CEP70 mRNA

NCBI chr 8:99,810,270...99,863,279
Ensembl chr 8:99,810,367...99,862,855

G

cingulin

increases expression

cordycepin results in increased expression of CGN mRNA

NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

affects expression

cordycepin affects the expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

CDC28 protein kinase regulatory subunit 2

increases expression

cordycepin results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin 7

increases expression

cordycepin results in increased expression of CLDN7 mRNA

NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171

G

contactin associated protein 2

increases expression

cordycepin results in increased expression of CNTNAP2 mRNA

NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027

G

collagen type I alpha 1 chain

multiple interactions

cordycepin inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of COL1A1 mRNA]]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

cAMP responsive element binding protein 1

multiple interactions
increases expression

cordycepin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [cordycepin results in increased expression of CREB1 mRNA]; PSB603 inhibits the reaction [cordycepin results in increased expression of CREB1 mRNA]; ZM 241385 inhibits the reaction [cordycepin results in increased expression of CREB1 mRNA]
cordycepin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of CREB1 protein]; cordycepin inhibits the reaction [POMC protein alternative form results in increased phosphorylation of CREB1 protein]

PMID:21972008 PMID:30269738 PMID:34070360

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

catenin beta 1

decreases expression
increases expression

cordycepin results in decreased expression of CTNNB1 protein
cordycepin results in increased expression of CTNNB1 mRNA

PMID:34070360 PMID:34858524

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

CXADR, Ig-like cell adhesion molecule

increases expression

cordycepin results in increased expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

cordycepin results in decreased expression of CXCR4 mRNA; cordycepin results in decreased expression of CXCR4 protein
4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [cordycepin results in decreased expression of CXCR4 protein]

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions

cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA]

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

decapping mRNA 2

decreases expression

cordycepin results in decreased expression of DCP2 mRNA

NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557

G

dopachrome tautomerase

multiple interactions

cordycepin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of DCT mRNA]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of DCT mRNA]

NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836

G

DNA-damage inducible transcript 3

affects expression

cordycepin affects the expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DExD-box helicase 21

decreases expression

cordycepin results in decreased expression of DDX21 mRNA

NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543

G

dehydrogenase/reductase 2

affects expression

cordycepin affects the expression of DHRS2 mRNA

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

dual specificity phosphatase 5

multiple interactions

[[cordycepin results in increased expression of CAV1 protein] which results in decreased expression of DUSP5 protein] which results in increased phosphorylation of MAPK8 protein

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

E2F transcription factor 1

multiple interactions

cordycepin inhibits the reaction [FGF9 protein results in increased expression of E2F1 protein]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 5

increases expression

cordycepin results in increased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

E2F transcription factor 8

decreases expression

cordycepin results in decreased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

EF-hand domain family, member D1

decreases expression

cordycepin results in decreased expression of EFHD1 mRNA

NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917

G

epidermal growth factor

increases expression
multiple interactions

cordycepin results in increased expression of EGF mRNA
cordycepin results in increased expression of and results in increased secretion of EGF protein

PMID:32042022 PMID:34070360

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

eukaryotic translation initiation factor 2A

increases phosphorylation

cordycepin results in increased phosphorylation of EIF2A protein

PMID:23690541 PMID:31145545

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

decreases expression

cordycepin results in decreased expression of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

cordycepin results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation
multiple interactions

cordycepin results in decreased phosphorylation of EIF4EBP1 protein
dorsomorphin inhibits the reaction [cordycepin results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ELAV like RNA binding protein 2

increases expression

cordycepin results in increased expression of ELAVL2 mRNA

NCBI chr 5:105,960,872...106,086,463
Ensembl chr 5:105,960,875...106,109,097

G

ELOVL fatty acid elongase 7

increases expression

cordycepin results in increased expression of ELOVL7 mRNA

NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845

G

epithelial cell adhesion molecule

increases expression

cordycepin results in increased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

erb-b2 receptor tyrosine kinase 2

decreases expression

cordycepin results in decreased expression of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

endoplasmic reticulum to nucleus signaling 1

decreases expression

cordycepin results in decreased expression of ERN1 protein

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

fatty acid binding protein 4

multiple interactions

cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas apoptotic inhibitory molecule 2

affects expression

cordycepin affects the expression of FAIM2 mRNA

NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168

G

fatty acid synthase

decreases expression

cordycepin results in decreased expression of FASN protein

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fem-1 homolog B

affects expression

cordycepin affects the expression of FEM1B mRNA

NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577

G

fibroblast growth factor 18

decreases expression

cordycepin results in decreased expression of FGF18 mRNA

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 6

multiple interactions

cordycepin results in increased expression of and results in increased secretion of FGF6 protein

NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447

G

fibroblast growth factor 9

multiple interactions
decreases expression

cordycepin inhibits the reaction [FGF9 protein results in decreased cleavage of CASP3 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCNA1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCNB1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCND1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of CCNE1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of CDK1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of CDK2 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of CDK4 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of E2F1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR2 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR3 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR4 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased expression of MKI67 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein]; cordycepin inhibits the reaction [FGF9 protein results in increased phosphorylation of RB1 protein]
cordycepin results in decreased expression of FGF9 mRNA

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

Fibroblast growth factor receptor 1

multiple interactions

cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR1 protein]

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 2

multiple interactions
decreases expression

cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR2 protein]
cordycepin results in decreased expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

decreases expression
multiple interactions

cordycepin results in decreased expression of FGFR3 mRNA
cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR3 protein]

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

multiple interactions

cordycepin inhibits the reaction [FGF9 protein results in increased expression of FGFR4 protein]

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

fibronectin 1

multiple interactions

cordycepin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

forkhead box O1

multiple interactions

cordycepin results in decreased expression of and results in decreased phosphorylation of FOXO1 protein

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

multiple interactions
decreases phosphorylation
increases expression
affects expression

cordycepin results in decreased expression of and results in decreased phosphorylation of FOXO3 protein
cordycepin results in decreased phosphorylation of FOXO3 protein
[cordycepin results in increased expression of FOXO3 protein] which results in increased expression of BAX protein
cordycepin results in decreased phosphorylation of and affects the localization of FOXO3 protein; pyrazolanthrone inhibits the reaction [cordycepin results in decreased phosphorylation of and affects the localization of FOXO3 protein]
cordycepin affects the expression of FOXO3 mRNA

PMID:28099944 PMID:31145545

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box O4

multiple interactions

cordycepin results in decreased expression of and results in decreased phosphorylation of FOXO4 protein

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

far upstream element binding protein 1

increases expression

cordycepin results in increased expression of FUBP1 mRNA

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

furin (paired basic amino acid cleaving enzyme)

decreases expression

cordycepin results in decreased expression of FURIN mRNA; cordycepin results in decreased expression of FURIN protein

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

fucosyltransferase 4

increases expression
multiple interactions

cordycepin results in increased expression of FUT4 protein
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [cordycepin results in increased expression of FUT4 protein]

NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682

G

fucosyltransferase 9

increases expression

cordycepin results in increased expression of FUT9 mRNA

NCBI chr 5:39,351,815...39,565,256
Ensembl chr 5:39,351,819...39,565,130

G

frizzled class receptor 3

increases expression

cordycepin results in increased expression of FZD3 mRNA

NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369

G

frizzled class receptor 5

increases expression

cordycepin results in increased expression of FZD5 mRNA

NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457

G

gamma-aminobutyric acid type A receptor subunit pi

decreases expression

cordycepin results in decreased expression of GABRP mRNA

NCBI chr10:18,143,031...18,169,595
Ensembl chr10:18,143,038...18,169,516

G

GTP cyclohydrolase 1

increases expression

cordycepin results in increased expression of GCH1 mRNA

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

glucosaminyl (N-acetyl) transferase 2

increases expression

cordycepin results in increased expression of GCNT2 mRNA

NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611

G

growth differentiation factor 15

affects expression

cordycepin affects the expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glial cell derived neurotrophic factor

increases secretion

cordycepin results in increased secretion of GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

GINS complex subunit 1

increases expression

cordycepin results in increased expression of GINS1 mRNA

NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936

G

G protein-coupled receptor 160

increases expression

cordycepin results in increased expression of GPR160 mRNA

NCBI chr 2:112,483,364...112,563,072
Ensembl chr 2:112,484,935...112,563,148

G

glutathione peroxidase 1

decreases expression
increases expression

cordycepin results in decreased expression of GPX1 mRNA
cordycepin results in increased expression of GPX1 mRNA

PMID:28987792 PMID:32714076

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor NMDA type subunit 2C

increases expression

cordycepin results in increased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

growth hormone regulated TBC protein 1

increases expression

cordycepin results in increased expression of GRTP1 mRNA

NCBI chr16:76,332,777...76,356,414
Ensembl chr16:76,283,103...76,354,440

G

glycogen synthase kinase 3 beta

increases expression
increases phosphorylation

cordycepin results in increased expression of GSK3B mRNA
cordycepin results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hepatocyte growth factor

affects expression
multiple interactions

cordycepin affects the expression of HGF mRNA
[cordycepin co-treated with TGFB1 protein] affects the expression of HGF mRNA; [cordycepin co-treated with TGFB1 protein] affects the secretion of HGF protein; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]]

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

high mobility group AT-hook 1

decreases expression

cordycepin results in decreased expression of HMGA1 mRNA

NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752

G

hyaluronan-mediated motility receptor

increases expression

cordycepin results in increased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

HRas proto-oncogene, GTPase

increases activity
multiple interactions

cordycepin results in increased activity of HRAS protein
HRAS protein mutant form inhibits the reaction [cordycepin results in increased expression of CDK2 protein]; HRAS protein mutant form inhibits the reaction [cordycepin results in increased expression of CDK4 protein]; HRAS protein mutant form inhibits the reaction [cordycepin results in increased expression of CDKN1B protein]; HRAS protein mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; HRAS protein mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

harakiri, BCL2 interacting protein

affects expression

cordycepin affects the expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

intercellular adhesion molecule 1

affects expression

cordycepin affects the expression of ICAM1 mRNA; cordycepin affects the expression of ICAM1 protein

PMID:12398919 PMID:28099944

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

decreases secretion

cordycepin results in decreased secretion of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

affects expression
multiple interactions

cordycepin affects the expression of IGF1 mRNA
cordycepin results in increased expression of and results in increased secretion of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

increases expression
increases secretion
multiple interactions

cordycepin results in increased expression of IL10 mRNA
cordycepin results in increased secretion of IL10 protein
cordycepin results in increased expression of and results in increased secretion of IL10 protein

PMID:12398919 PMID:19051361

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

affects expression

cordycepin affects the expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases secretion
multiple interactions

cordycepin results in increased secretion of IL1B protein
cordycepin inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]
cordycepin inhibits the reaction [AGT protein results in increased expression of IL1B protein]; cordycepin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; cordycepin inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; cordycepin inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]; cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; cordycepin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; cordycepin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; cordycepin inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]; cordycepin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; cordycepin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK8 protein]; cordycepin inhibits the reaction [IL1B protein results in increased secretion of CXCL5 protein]; cordycepin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; cordycepin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
[ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; [ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:19051361 PMID:19056796 PMID:24346509 PMID:25342887 PMID:36731150

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases secretion

cordycepin results in decreased secretion of IL2 protein

PMID:12398919 PMID:19051361

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 2 receptor subunit alpha

affects expression

cordycepin affects the expression of IL2RA protein

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 4

multiple interactions
decreases secretion

cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased secretion of IL4 protein]
cordycepin results in decreased secretion of IL4 protein

PMID:19051361 PMID:30183461

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

decreases secretion

cordycepin results in decreased secretion of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions
affects expression
increases secretion

cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased secretion of IL6 protein]
cordycepin affects the expression of IL6 mRNA
cordycepin inhibits the reaction [testosterone enanthate results in increased expression of IL6 protein]
cordycepin inhibits the reaction [AGT protein results in increased expression of IL6 protein]; cordycepin inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
cordycepin results in increased secretion of IL6 protein

PMID:19051361 PMID:24346509 PMID:28099944 PMID:30183461 PMID:36015278 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions
increases expression
increases secretion

cordycepin promotes the reaction [Glucose results in increased secretion of INS1 protein]
cordycepin results in increased expression of INS1 mRNA
cordycepin results in increased secretion of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

integrin subunit alpha 5

increases expression

cordycepin results in increased expression of ITGA5 protein

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit alpha V

increases expression

cordycepin results in increased expression of ITGAV protein

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

G

Janus kinase 2

multiple interactions
increases phosphorylation

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [cordycepin results in increased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

cordycepin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinase insert domain receptor

multiple interactions

[cordycepin co-treated with apatinib] results in decreased expression of KDR protein; cordycepin inhibits the reaction [AGT protein results in increased expression of KDR protein]

PMID:33014856 PMID:36731150

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

laminin subunit alpha 1

increases expression

cordycepin results in increased expression of LAMA1 mRNA

NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478

G

lipocalin 2

affects expression

cordycepin affects the expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lymphoid enhancer binding factor 1

increases expression

cordycepin results in increased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

LIF, interleukin 6 family cytokine

increases expression
multiple interactions

cordycepin results in increased expression of LIF mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [cordycepin results in increased expression of LIF mRNA]

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lipoprotein lipase

multiple interactions

cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

microtubule-associated protein 1 light chain 3 alpha

increases expression

cordycepin results in increased expression of MAP1LC3A mRNA

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
affects expression

Chloroquine inhibits the reaction [cordycepin results in increased expression of MAP1LC3B mRNA]
cordycepin affects the expression of MAP1LC3B mRNA

PMID:36299321 PMID:36881089

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 1

increases phosphorylation

cordycepin results in increased phosphorylation of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

increases phosphorylation

cordycepin results in increased phosphorylation of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

cordycepin inhibits the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
cordycepin results in increased phosphorylation of MAPK1 protein
cordycepin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; cordycepin results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
cordycepin results in increased phosphorylation of and results in increased activity of MAPK1 protein; HRAS protein mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:20043135 PMID:21972008 PMID:22366198 PMID:25342887 PMID:33172093 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

cordycepin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

cordycepin inhibits the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
cordycepin results in increased phosphorylation of MAPK3 protein
cordycepin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; cordycepin results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
cordycepin results in increased phosphorylation of and results in increased activity of MAPK3 protein; HRAS protein mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 protein affects the reaction [cordycepin results in decreased expression of CDK2 protein]; MAPK3 protein affects the reaction [cordycepin results in decreased expression of CDK4 protein]; MAPK3 protein affects the reaction [cordycepin results in increased expression of CDKN1B protein]

PMID:20043135 PMID:21972008 PMID:22366198 PMID:25342887 PMID:33172093 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation
affects expression
multiple interactions

cordycepin results in increased phosphorylation of MAPK8 protein
cordycepin affects the expression of MAPK8 mRNA
[[cordycepin results in increased expression of CAV1 protein] which results in decreased expression of DUSP5 protein] which results in increased phosphorylation of MAPK8 protein; [Doxorubicin co-treated with cordycepin] results in decreased expression of MAPK8 protein; cordycepin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [cordycepin results in increased phosphorylation of MAPK8 protein]
cordycepin results in increased phosphorylation of and results in increased activity of MAPK8 protein
cordycepin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]

PMID:19056796 PMID:22366198 PMID:25342887 PMID:28099944 PMID:35186504 More...

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microtubule-associated protein tau

multiple interactions
increases phosphorylation

cordycepin inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPT protein]
cordycepin results in increased phosphorylation of MAPT protein

PMID:30031108 PMID:33184027

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MET proto-oncogene, receptor tyrosine kinase

multiple interactions

[cordycepin co-treated with TGFB1 protein] affects the phosphorylation of MET protein

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

melanocyte inducing transcription factor

multiple interactions

cordycepin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of MITF protein]

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

mitochondrial matrix import factor 23

increases expression

cordycepin results in increased expression of CCDC58 mRNA

NCBI chr11:64,660,711...64,681,000
Ensembl chr11:64,660,711...64,681,000

G

marker of proliferation Ki-67

multiple interactions
increases expression

cordycepin inhibits the reaction [FGF9 protein results in increased expression of MKI67 protein]
cordycepin results in increased expression of MKI67 mRNA

PMID:33172093 PMID:34070360

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 1

multiple interactions

cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

multiple interactions

cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

decreases expression
decreases activity
multiple interactions

cordycepin results in decreased expression of MMP2 mRNA; cordycepin results in decreased expression of MMP2 protein
cordycepin results in decreased activity of MMP2 protein
Chloroquine inhibits the reaction [cordycepin results in decreased activity of MMP2 protein]; Chloroquine inhibits the reaction [cordycepin results in decreased expression of MMP2 mRNA]

PMID:35732609 PMID:36299321

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

decreases expression
decreases activity
multiple interactions

cordycepin results in decreased expression of MMP9 protein
cordycepin results in decreased activity of MMP9 protein
[Doxorubicin co-treated with cordycepin] results in decreased expression of MMP9 protein; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; cordycepin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; cordycepin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]

PMID:20043135 PMID:30269738 PMID:35186504 PMID:35732609 PMID:36299321

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

meiotic nuclear divisions 1

increases expression

cordycepin results in increased expression of MND1 mRNA

NCBI chr 2:169,433,523...169,496,081
Ensembl chr 2:169,433,540...169,496,096

G

metal response element binding transcription factor 2

increases expression

cordycepin results in increased expression of MTF2 mRNA

NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524

G

mechanistic target of rapamycin kinase

affects expression
multiple interactions
increases phosphorylation

cordycepin affects the expression of MTOR mRNA
[cordycepin co-treated with Cisplatin] results in decreased phosphorylation of MTOR protein
cordycepin results in increased phosphorylation of MTOR protein

PMID:31145545 PMID:33520990 PMID:34070360 PMID:36881089

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 20, cell surface associated

increases expression

cordycepin results in increased expression of MUC20 mRNA

NCBI chr11:67,987,816...68,001,496
Ensembl chr11:67,987,800...68,001,495

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression
increases expression

[Doxorubicin co-treated with cordycepin] results in decreased expression of MYC protein
cordycepin results in decreased expression of MYC mRNA; cordycepin results in decreased expression of MYC protein
cordycepin results in increased expression of MYC mRNA

PMID:25282637 PMID:34070360 PMID:35186504

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

multiple interactions

cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

Nanog homeobox

affects expression
multiple interactions
increases expression

cordycepin affects the expression of NANOG mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [cordycepin results in increased expression of NANOG protein]
sirtinol inhibits the reaction [cordycepin results in increased expression of NANOG mRNA]

PMID:32042022 PMID:36881089

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression

[Doxorubicin co-treated with cordycepin] results in decreased expression of NFKB1 protein
cordycepin results in decreased expression of NFKB1 mRNA

PMID:35186504 PMID:36881089

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
decreases phosphorylation

cordycepin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
cordycepin results in decreased phosphorylation of NFKBIA protein
cordycepin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]

PMID:16899239 PMID:24346509 PMID:25342887 PMID:31746344

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor receptor

affects expression

cordycepin affects the expression of NGFR mRNA

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

nucleolar and coiled-body phosphoprotein 1

decreases expression

cordycepin results in decreased expression of NOLC1 mRNA

NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088

G

nitric oxide synthase 2

multiple interactions

[ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; [ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
cordycepin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]

PMID:16899239 PMID:24346509 PMID:25342887

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

cordycepin inhibits the reaction [AGT protein results in increased expression of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

multiple interactions

[cordycepin co-treated with thymoquinone] results in decreased expression of NOTCH1 protein

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

nucleoporin 93

decreases expression

cordycepin results in decreased expression of NUP93 mRNA

NCBI chr19:10,684,214...10,788,009
Ensembl chr19:10,682,075...10,788,026

G

nuclear protein 1, transcriptional regulator

affects expression

cordycepin affects the expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

nucleolar and spindle associated protein 1

increases expression

cordycepin results in increased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

occludin

increases expression

cordycepin results in increased expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

protein kinase C and casein kinase substrate in neurons 1

increases expression

cordycepin results in increased expression of PACSIN1 mRNA

NCBI chr20:5,718,134...5,768,064
Ensembl chr20:5,719,857...5,765,313

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]

PMID:23941773 PMID:24704558 PMID:26303320 PMID:35732609

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pancreatic and duodenal homeobox 1

multiple interactions
increases expression

cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PDX1 mRNA]; cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PDX1 protein]
cordycepin results in increased expression of PDX1 mRNA; cordycepin results in increased expression of PDX1 protein

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

platelet and endothelial cell adhesion molecule 1

multiple interactions

cordycepin inhibits the reaction [AGT protein results in increased expression of PECAM1 protein]

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

placental growth factor

multiple interactions

cordycepin results in increased expression of and results in increased secretion of PGF protein

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

affects binding

cordycepin binds to PIK3CG protein

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

podocalyxin-like

increases expression

cordycepin results in increased expression of PODXL mRNA

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

RNA polymerase I subunit B

decreases expression

cordycepin results in decreased expression of POLR1B mRNA

NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379

G

proopiomelanocortin

multiple interactions

cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of DCT mRNA]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of MITF protein]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of TYR mRNA]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of TYR protein]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of TYRP1 protein]; cordycepin inhibits the reaction [POMC protein alternative form results in increased phosphorylation of CREB1 protein]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

POU class 5 homeobox 1

affects expression
increases expression
multiple interactions

cordycepin affects the expression of POU5F1 mRNA
cordycepin results in increased expression of POU5F1 protein
sirtinol inhibits the reaction [cordycepin results in increased expression of POU5F1 mRNA]

PMID:32042022 PMID:36881089

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor gamma

multiple interactions

cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

periplakin

increases expression

cordycepin results in increased expression of PPL mRNA

NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575

G

protein phosphatase 1, regulatory subunit 15A

affects expression

cordycepin affects the expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

cordycepin inhibits the reaction [testosterone enanthate results in decreased phosphorylation of PRKAA1 protein]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

cordycepin inhibits the reaction [testosterone enanthate results in decreased phosphorylation of PRKAA2 protein]

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase AMP-activated non-catalytic subunit beta 1

increases phosphorylation
multiple interactions

cordycepin results in increased phosphorylation of PRKAB1 protein
dorsomorphin inhibits the reaction [cordycepin results in increased phosphorylation of PRKAB1 protein]

NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661

G

protein kinase C, zeta

increases expression

cordycepin results in increased expression of PRKCZ mRNA

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

prostaglandin E receptor 4

multiple interactions

cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGER4 mRNA]

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; [ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
cordycepin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; cordycepin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

PMID:16899239 PMID:24346509 PMID:25342887 PMID:30269738

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases phosphorylation

cordycepin results in decreased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, receptor type, C

affects expression

cordycepin affects the expression of PTPRC protein alternative form

NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692

G

RB transcriptional corepressor 1

multiple interactions

cordycepin inhibits the reaction [FGF9 protein results in increased phosphorylation of RB1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

cordycepin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
cordycepin inhibits the reaction [testosterone enanthate results in increased expression of RELA protein]
[cordycepin co-treated with 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine] results in decreased localization of RELA protein; cordycepin inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]; cordycepin results in decreased phosphorylation of and affects the localization of RELA protein

PMID:16899239 PMID:24346509 PMID:25342887 PMID:31746344 PMID:36015278

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

regulator of G-protein signaling 9

decreases expression

cordycepin results in decreased expression of RGS9 mRNA

NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892

G

rhophilin, Rho GTPase binding protein 2

increases expression

cordycepin results in increased expression of RHPN2 mRNA

NCBI chr 1:87,991,143...88,051,895
Ensembl chr 1:87,991,144...88,051,902

G

ribosomal protein S6 kinase B1

increases phosphorylation
multiple interactions

cordycepin results in increased phosphorylation of RPS6KB1 protein
[cordycepin co-treated with Cisplatin] results in decreased phosphorylation of RPS6KB1 protein; [cordycepin co-treated with Cisplatin] results in decreased phosphorylation of S6K protein

PMID:33520990 PMID:34070360

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribosomal RNA processing 1B

decreases expression

cordycepin results in decreased expression of RRP1B mRNA

NCBI chr20:10,123,111...10,148,704
Ensembl chr20:10,123,125...10,147,928

G

RUNX family transcription factor 2

multiple interactions

cordycepin inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA]]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

S100 calcium binding protein A9

affects expression

cordycepin affects the expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

selectin E

increases expression

cordycepin results in increased expression of SELE mRNA

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

sirtuin 1

affects expression
affects phosphorylation
multiple interactions

cordycepin affects the expression of SIRT1 mRNA
cordycepin affects the phosphorylation of SIRT1 protein
sirtinol inhibits the reaction [cordycepin results in increased expression of SIRT1 mRNA]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

SLAIN motif family, member 1

increases expression

cordycepin results in increased expression of SLAIN1 mRNA

NCBI chr15:80,482,818...80,542,461
Ensembl chr15:80,482,367...80,542,350

G

solute carrier family 2 member 1

increases expression
multiple interactions

cordycepin results in increased expression of SLC2A1 mRNA; cordycepin results in increased expression of SLC2A1 protein
cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC2A1 mRNA]; cordycepin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC2A1 protein]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 5 member 6

decreases expression

cordycepin results in decreased expression of SLC5A6 mRNA

NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712

G

structural maintenance of chromosomes 4

increases expression

cordycepin results in increased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

snail family transcriptional repressor 1

decreases expression
multiple interactions

cordycepin results in decreased expression of SNAI1 mRNA; cordycepin results in decreased expression of SNAI1 protein
cordycepin results in decreased expression of and results in decreased localization of SNAI1 protein; thymoquinone promotes the reaction [cordycepin results in decreased expression of SNAI1 protein]

PMID:35732609 PMID:35774120

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression
multiple interactions

cordycepin results in decreased expression of SNAI2 mRNA; cordycepin results in decreased expression of SNAI2 protein
cordycepin results in decreased expression of and results in decreased localization of SNAI2 protein; thymoquinone promotes the reaction [cordycepin results in decreased expression of SNAI2 protein]

PMID:35732609 PMID:35774120

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

superoxide dismutase 1

decreases expression
increases expression
multiple interactions

cordycepin results in decreased expression of SOD1 mRNA
cordycepin results in increased expression of SOD1 mRNA
cordycepin inhibits the reaction [testosterone enanthate results in decreased activity of SOD1 protein]

PMID:28987792 PMID:32714076 PMID:36015278

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sortilin related receptor 1

increases expression

cordycepin results in increased expression of SORL1 mRNA

NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513

G

SRY-box transcription factor 2

multiple interactions
affects expression

sirtinol inhibits the reaction [cordycepin results in increased expression of SOX2 mRNA]
cordycepin affects the expression of SOX2 protein
cordycepin affects the expression of SOX2 mRNA

PMID:32042022 PMID:36881089

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

Sp1 transcription factor

multiple interactions
affects metabolic processing
decreases expression
increases activity

cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]; cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA]
cordycepin affects the metabolism of SP1 polyA tail
cordycepin results in decreased expression of SP1 mRNA; cordycepin results in decreased expression of SP1 protein
cordycepin inhibits the reaction [[SP1 protein binds to TUBA1B promoter] which results in decreased expression of SP1 protein]; cordycepin inhibits the reaction [[SP1 protein binds to TUBA1B promoter] which results in decreased expression of TUBA1B protein]; cordycepin inhibits the reaction [SP1 protein binds to TUBA1B promoter]
cordycepin results in increased activity of SP1 protein

PMID:19051361 PMID:23690541 PMID:25282637 PMID:33948356

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

Sp3 transcription factor

increases activity

cordycepin results in increased activity of SP3 protein

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

Sp7 transcription factor

multiple interactions

cordycepin inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of SP7 mRNA]]

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

SPARC like 1

decreases expression

cordycepin results in decreased expression of SPARCL1 mRNA

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

SPC25 component of NDC80 kinetochore complex

increases expression

cordycepin results in increased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

sterol regulatory element binding transcription factor 1

decreases expression

cordycepin results in decreased expression of SREBF1 protein

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

signal transducer and activator of transcription 3

increases phosphorylation
multiple interactions

cordycepin results in increased phosphorylation of STAT3 protein
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [cordycepin results in increased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

spermatid perinuclear RNA binding protein

increases expression

cordycepin results in increased expression of STRBP mRNA

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

telomerase reverse transcriptase

multiple interactions
decreases expression

cordycepin results in decreased expression of and results in decreased phosphorylation of TERT protein
cordycepin results in decreased expression of TERT mRNA

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transcription factor Dp-2

increases expression

cordycepin results in increased expression of TFDP2 mRNA

NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682

G

transferrin receptor

affects expression

cordycepin affects the expression of TFRC protein

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 1

increases expression
multiple interactions

cordycepin results in increased expression of TGFB1 mRNA
[cordycepin co-treated with TGFB1 protein] affects the expression of HGF mRNA; [cordycepin co-treated with TGFB1 protein] affects the phosphorylation of MET protein; [cordycepin co-treated with TGFB1 protein] affects the secretion of HGF protein; cordycepin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; cordycepin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]]
cordycepin results in increased expression of and results in increased secretion of TGFB1 protein

PMID:22134049 PMID:34070360

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

increases expression
increases secretion

cordycepin results in increased expression of TGFB2 protein
cordycepin results in increased secretion of TGFB2 protein
cordycepin results in increased expression of TGFB2 mRNA

PMID:26303320 PMID:34070360

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

increases secretion

cordycepin results in increased secretion of TGFB3 protein

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

toll-like receptor 2

affects expression

cordycepin affects the expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

increases secretion
multiple interactions

cordycepin results in increased secretion of TNF protein
cordycepin inhibits the reaction [Calcium Chloride results in increased expression of TNF protein]; cordycepin inhibits the reaction [testosterone enanthate results in increased expression of TNF protein]
cordycepin inhibits the reaction [AGT protein results in increased expression of TNF protein]
[ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate co-treated with cordycepin] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased secretion of TNF protein]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; cordycepin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

PMID:16899239 PMID:19051361 PMID:25342887 PMID:30183461 PMID:36015278 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

affects expression

cordycepin affects the expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF receptor superfamily member 25

increases expression

cordycepin results in increased expression of TNFRSF25 protein

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

TNF receptor superfamily member 9

affects expression

cordycepin affects the expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

tumor protein p53

multiple interactions
affects expression
increases phosphorylation
increases expression

ADORA2A mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]; cordycepin promotes the reaction [Etoposide results in increased expression of TP53 protein]; cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]
[Cisplatin co-treated with cordycepin] results in increased phosphorylation of TP53 protein
cordycepin affects the expression of TP53 mRNA
cordycepin results in increased phosphorylation of TRP53 protein
cordycepin results in increased expression of TP53 mRNA

PMID:23690541 PMID:24704558 PMID:26303320 PMID:28987792 PMID:33520990 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thymic stromal lymphopoietin

multiple interactions

cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased expression of TSLP mRNA]; cordycepin inhibits the reaction [Dinitrofluorobenzene results in increased secretion of TSLP protein]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

tubulin, alpha 1A

decreases expression

cordycepin results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, alpha 1B

affects metabolic processing
decreases expression
multiple interactions

cordycepin affects the metabolism of TUBA1B polyA tail
cordycepin results in decreased expression of TUBA1B protein
cordycepin inhibits the reaction [[SP1 protein binds to TUBA1B promoter] which results in decreased expression of SP1 protein]; cordycepin inhibits the reaction [[SP1 protein binds to TUBA1B promoter] which results in decreased expression of TUBA1B protein]; cordycepin inhibits the reaction [SP1 protein binds to TUBA1B promoter]

NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186

G

twist family bHLH transcription factor 1

multiple interactions
decreases expression

[Doxorubicin co-treated with cordycepin] results in decreased expression of TWIST1 protein; cordycepin results in decreased expression of and results in decreased localization of TWIST1 protein; thymoquinone promotes the reaction [cordycepin results in decreased expression of TWIST1 protein]
cordycepin results in decreased expression of TWIST1 mRNA

PMID:35186504 PMID:35774120

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

G

thioredoxin interacting protein

affects expression

cordycepin affects the expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

tyrosinase

multiple interactions

cordycepin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TYR mRNA]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of TYR mRNA]; cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of TYR protein]

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

multiple interactions

cordycepin inhibits the reaction [POMC protein alternative form results in increased expression of TYRP1 protein]

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

G

unc-5 netrin receptor B

affects expression

cordycepin affects the expression of UNC5B mRNA

NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537

G

ubiquitin specific peptidase 28

increases expression

cordycepin results in increased expression of USP28 mRNA

NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229

G

vav guanine nucleotide exchange factor 3

affects expression

cordycepin affects the expression of VAV3 mRNA

NCBI chr 2:197,011,901...197,354,321
Ensembl chr 2:197,011,831...197,354,321

G

vascular endothelial growth factor A

multiple interactions
increases expression

[cordycepin co-treated with apatinib] results in decreased expression of VEGFA protein; cordycepin inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; cordycepin results in increased expression of and results in increased secretion of VEGFA protein
cordycepin results in increased expression of VEGFA mRNA

PMID:33014856 PMID:34070360 PMID:36731150

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor D

increases secretion

cordycepin results in increased secretion of VEGFD protein

NCBI chr X:30,073,122...30,108,413
Ensembl chr X:30,074,163...30,108,295

G

villin 1

affects expression

cordycepin affects the expression of VIL1 mRNA

NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858

G

vimentin

decreases expression

cordycepin results in decreased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-box binding protein 1

increases expression

cordycepin results in increased expression of XBP1 protein

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

xanthine dehydrogenase

affects expression

cordycepin affects the expression of XDH mRNA

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

X-linked inhibitor of apoptosis

decreases expression
multiple interactions

cordycepin results in decreased expression of XIAP protein
Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein]

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

zinc finger E-box binding homeobox 1

multiple interactions
decreases expression

[Doxorubicin co-treated with cordycepin] results in decreased expression of ZEB1 protein; cordycepin results in decreased expression of and results in decreased localization of ZEB1 protein; thymoquinone promotes the reaction [cordycepin results in decreased expression of ZEB1 protein]
cordycepin results in decreased expression of ZEB1 mRNA

PMID:35186504 PMID:35774120

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

cyclic ADP-beta-D-ribose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD38 molecule

decreases abundance

CD38 gene mutant form results in decreased abundance of Cyclic ADP-Ribose

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

homer scaffold protein 1

multiple interactions

HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]]

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

ryanodine receptor 2

multiple interactions

HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]]

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

decanoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid dehydrogenase like 2

multiple interactions

[decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

peroxisomal trans-2-enoyl-CoA reductase

multiple interactions

[decanoyl-coenzyme A co-treated with NADP] binds to PECR protein

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

glutaryl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 4

affects hydrolysis

ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

G

acyl-CoA thioesterase 8

affects hydrolysis

ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A

NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851

hexanoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

peroxisomal trans-2-enoyl-CoA reductase

multiple interactions

[hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

isobutyryl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

lysine acetyltransferase 2B

affects binding

isobutyryl-coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

lauroyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 1

multiple interactions

lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

hydroxysteroid dehydrogenase like 2

multiple interactions

[lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

peroxisomal trans-2-enoyl-CoA reductase

multiple interactions

[lauroyl-coenzyme A co-treated with NADP] binds to PECR protein

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

malonyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

malonyl-CoA decarboxylase

multiple interactions

PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A]

NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793

G

peroxisome proliferator activated receptor alpha

multiple interactions

PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

methacrylyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

enoyl-CoA hydratase, short chain 1

increases abundance

ECHS1 gene mutant form results in increased abundance of methacrylyl-coenzyme A

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

3-hydroxyisobutyryl-CoA hydrolase

increases abundance

HIBCH gene mutant form results in increased abundance of methacrylyl-coenzyme A

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

myristoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

diazepam binding inhibitor

affects binding

S-tetradecanoyl-coenzyme A binds to DBI protein

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

glutathione S-transferase alpha 1

multiple interactions

S-tetradecanoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

peroxisome proliferator activated receptor alpha

multiple interactions

S-tetradecanoyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

N(6),N(6)-dimethyladenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase domain 17

decreases expression
multiple interactions

N(6),N(6)-dimethyladenosine results in decreased expression of ADAM17 protein
N(6),N(6)-dimethyladenosine inhibits the reaction [Cycloheximide results in decreased stability of ADAM17 protein]

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

basigin (Ok blood group)

decreases expression

N(6),N(6)-dimethyladenosine results in decreased expression of BSG protein

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

N(6)-methyladenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

FTO, alpha-ketoglutarate dependent dioxygenase

multiple interactions

[FTO results in decreased abundance of N-methyladenosine] which results in decreased methylation of SETD2 mRNA alternative form

NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083

G

insulin-like growth factor binding protein 4

multiple interactions

[[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA] which affects the expression of IGFBP4 protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of IGFBP4 protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of MCL1 mRNA]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

affects abundance
multiple interactions

METTL3 protein affects the abundance of N-methyladenosine
METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of MCL1 mRNA]; METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of SETD2 mRNA alternative form]
[[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA] which affects the expression of IGFBP4 protein; [[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of IGFBP4 protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of IGFBP4 mRNA; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA; [METTL3 results in increased abundance of N-methyladenosine] which results in increased methylation of SETD2 mRNA alternative form

PMID:35971034 PMID:36260529

NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041

G

microRNA 145

increases abundance
multiple interactions

MIR145 mRNA results in increased abundance of N-methyladenosine
[MIR145 mRNA results in decreased expression of YTHDF2 protein] which results in increased abundance of N-methyladenosine; YTHDF2 protein inhibits the reaction [MIR145 mRNA results in increased abundance of N-methyladenosine]

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

G

pappalysin

multiple interactions

[[METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the expression of PAPPA protein; [METTL3 protein affects the abundance of N-methyladenosine] which affects the methylation of PAPPA mRNA

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

G

SET domain containing 2, histone lysine methyltransferase

multiple interactions

METTL3 inhibits the reaction [N-methyladenosine results in decreased expression of SETD2 mRNA alternative form]
[FTO results in decreased abundance of N-methyladenosine] which results in decreased methylation of SETD2 mRNA alternative form; [METTL3 results in increased abundance of N-methyladenosine] which results in increased methylation of SETD2 mRNA alternative form

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

YTH N6-methyladenosine RNA binding protein F2

multiple interactions
affects binding

[MIR145 mRNA results in decreased expression of YTHDF2 protein] which results in increased abundance of N-methyladenosine; YTHDF2 protein inhibits the reaction [MIR145 mRNA results in increased abundance of N-methyladenosine]
YTHDF2 protein binds to N-methyladenosine

PMID:28104805 PMID:34213887

NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144

N-ethyl-5'-carboxamidoadenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A2B receptor

affects response to substance

ADORA2B protein affects the susceptibility to Adenosine-5'-(N-ethylcarboxamide)

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

adenosine A3 receptor

affects binding

Adenosine-5'-(N-ethylcarboxamide) binds to ADORA3 protein

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

caspase 1

increases activity

Adenosine-5'-(N-ethylcarboxamide) results in increased activity of CASP1 mRNA; Adenosine-5'-(N-ethylcarboxamide) results in increased activity of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

C-C motif chemokine ligand 2

increases secretion

Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

epoxide hydrolase 2

increases response to substance

EPHX2 gene mutant form results in increased susceptibility to Adenosine-5'-(N-ethylcarboxamide)

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

interleukin 13

increases secretion

Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

surfactant protein B

increases secretion
multiple interactions

Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein
Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]

PMID:11704537 PMID:14565945

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

surfactant protein C

increases secretion
multiple interactions

Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein
Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]

PMID:11704537 PMID:14565945

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

tumor necrosis factor

multiple interactions

5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; ZM 241385 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

increases expression

Adenosine-5'-(N-ethylcarboxamide) results in increased expression of TNFSF11 mRNA; Adenosine-5'-(N-ethylcarboxamide) results in increased expression of TNFSF11 protein

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

thioredoxin interacting protein

increases activity

Adenosine-5'-(N-ethylcarboxamide) results in increased activity of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

vascular endothelial growth factor A

multiple interactions

Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA mRNA]; Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA protein]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA mRNA]]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) inhibits the reaction [Cyclosporine results in decreased expression of VEGFA protein]]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

oleoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 1

multiple interactions

oleoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

peroxisome proliferator activated receptor alpha

multiple interactions

oleoyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

oleoyl-coenzyme A binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

P(1),P(4)-bis(5'-adenosyl) tetraphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

nudix hydrolase 2

increases hydrolysis

NUDT2 protein results in increased hydrolysis of diadenosine tetraphosphate

NCBI chr 5:56,628,265...56,643,104
Ensembl chr 5:56,628,265...56,643,104

G

tyrosine hydroxylase

multiple interactions

diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

P(1),P(5)-bis(5'-adenosyl) pentaphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CF transmembrane conductance regulator

multiple interactions

P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

nudix hydrolase 11

multiple interactions
increases metabolic processing

[NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of adenosine 5'-tetraphosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; manganese chloride promotes the reaction [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate]

NCBI chr X:16,326,775...16,333,396
Ensembl chr X:16,326,598...16,333,145

G

sirtuin 1

multiple interactions

P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

P(1),P(6)-bis(5'-adenosyl)hexaphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nudix hydrolase 11

multiple interactions
increases metabolic processing

[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate; [NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate

NCBI chr X:16,326,775...16,333,396
Ensembl chr X:16,326,598...16,333,145

palmitoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 1

increases metabolic processing
multiple interactions

ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A
[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide; benz(a)anthracene promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Tetrachlorodibenzodioxin promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

carboxylesterase 1D

increases hydrolysis

CES1 protein results in increased hydrolysis of Palmitoyl Coenzyme A

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carnitine palmitoyltransferase 1A

multiple interactions

valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Palmitoyl Coenzyme A]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

diacylglycerol O-acyltransferase 1

multiple interactions

DGAT1 protein results in increased metabolism of [Palmitoyl Coenzyme A co-treated with Vitamin A]

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

glutathione S-transferase alpha 1

multiple interactions

Palmitoyl Coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

hepatocyte nuclear factor 4, alpha

decreases expression

Palmitoyl Coenzyme A results in decreased expression of HNF4A mRNA; Palmitoyl Coenzyme A results in decreased expression of HNF4A protein

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

peroxisome proliferator activated receptor alpha

multiple interactions

Palmitoyl Coenzyme A binds to and results in increased activity of PPARA protein
Acetylglucosamine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Budesonide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Fenofibrate promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gamma-Aminobutyric Acid inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gedunin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]; Pravastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; salicylamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolazoline inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

PMID:11139385 PMID:18812576

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Palmitoyl Coenzyme A binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

sex hormone binding globulin

decreases expression

Palmitoyl Coenzyme A results in decreased expression of SHBG mRNA; Palmitoyl Coenzyme A results in decreased expression of SHBG protein

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

puromycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport
increases expression
affects response to substance

ABCB1 protein results in increased transport of Puromycin
Puromycin results in increased expression of ABCB1A mRNA; Puromycin results in increased expression of ABCB1A protein
ABCB1A protein affects the susceptibility to Puromycin

PMID:14675146 PMID:20018165

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

increases expression

Puromycin results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

aryl hydrocarbon receptor

multiple interactions

Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]; Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]

PMID:10777561 PMID:25797602

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions

Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

BCL2 associated X, apoptosis regulator

affects localization

Puromycin affects the localization of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Puromycin results in decreased expression of BCL2 protein
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

caspase 3

multiple interactions
increases activity

Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein]

PMID:14502240 PMID:21244482

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

Puromycin results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 2

decreases expression

Puromycin results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 4

decreases expression

Puromycin results in decreased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

CD2-associated protein

decreases expression

Puromycin results in decreased expression of CD2AP mRNA

NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199

G

cadherin 3

decreases expression

Puromycin results in decreased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

catenin beta 1

affects localization

Puromycin affects the localization of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

[Puromycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA
Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Puromycin results in increased expression of CYP1A1 mRNA

PMID:2985607 PMID:15385644

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DEF6 guanine nucleotide exchange factor

affects localization

Puromycin affects the localization of DEF6 protein

NCBI chr20:6,268,579...6,290,030
Ensembl chr20:6,268,601...6,289,961

G

heme oxygenase 1

increases expression

Puromycin results in increased expression of HMOX1

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 6 receptor

decreases expression

Puromycin results in decreased expression of IL6R protein modified form

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

interferon regulatory factor 1

multiple interactions

Puromycin inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein]

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

low density lipoprotein receptor

multiple interactions
decreases expression

Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR protein]
Puromycin results in decreased expression of LDLR mRNA; Puromycin results in decreased expression of LDLR protein

PMID:12524230 PMID:22388943

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

microRNA 122

multiple interactions

Puromycin results in decreased expression of and results in decreased secretion of MIR122 mRNA

NCBI chr18:58,758,703...58,758,787

G

microRNA 143

multiple interactions

Puromycin results in decreased expression of and results in decreased secretion of MIR143 mRNA

NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110

G

microRNA 155

affects expression

Puromycin affects the expression of MIR155

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 3473

multiple interactions

Puromycin results in increased expression of and results in increased secretion of MIR3473 mRNA

NCBI chr13:39,499,246...39,499,312
Ensembl chr13:39,499,246...39,499,312

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Puromycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

optineurin

multiple interactions

OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein]

NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251

G

prostaglandin E receptor 4

multiple interactions

[Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

thromboxane A2 receptor

multiple interactions

[Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

G

TCDD-inducible poly(ADP-ribose) polymerase

multiple interactions

Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA]

NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327

G

vascular endothelial growth factor A

decreases expression
multiple interactions
increases secretion

Puromycin results in decreased expression of VEGFA protein
OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein]

PMID:20116850 PMID:25096716

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

S-adenosyl-L-homocysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosylhomocysteinase

increases hydrolysis

AHCY results in increased hydrolysis of S-Adenosylhomocysteine

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

increases abundance
multiple interactions

AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

5'-aminolevulinate synthase 2

multiple interactions

[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

amyloid beta precursor protein

increases expression
decreases methylation
multiple interactions

S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein

PMID:19635394 PMID:22064374

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ATPase copper transporting beta

increases abundance

ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

beta-secretase 1

increases expression

S-Adenosylhomocysteine results in increased expression of BACE1 protein

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

coactivator-associated arginine methyltransferase 1

decreases activity

S-Adenosylhomocysteine results in decreased activity of CARM1 protein

NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689

G

collagen type I alpha 1 chain

decreases expression

S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

decreases expression

S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

catechol-O-methyltransferase

decreases activity

S-Adenosylhomocysteine results in decreased activity of COMT protein

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

DNA methyltransferase 1

decreases activity
multiple interactions

S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]

PMID:16037419 PMID:22064374

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

fibroblast growth factor 19

decreases abundance

FGF19 protein results in decreased abundance of S-Adenosylhomocysteine

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

hemoglobin subunit beta

multiple interactions

[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hydroxymethylbilane synthase

multiple interactions

[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]

NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957

G

matrix metallopeptidase 2

increases expression
multiple interactions

S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

NFKB inhibitor alpha

decreases expression

S-Adenosylhomocysteine results in decreased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear receptor subfamily 0, group B, member 2

decreases abundance

NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

8-oxoguanine DNA glycosylase

multiple interactions
decreases methylation
decreases expression

Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

phosphatidylethanolamine N-methyltransferase

multiple interactions

PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]

NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013

G

PPARG coactivator 1 alpha

increases expression

S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein arginine methyltransferase 1

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT1 protein

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

protein arginine methyltransferase 5

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT5 protein

NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296

G

protein arginine methyltransferase 6

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT6 protein

NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648

G

protein arginine methyltransferase 7

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT7 protein

NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577

G

presenilin 1

multiple interactions
decreases methylation
increases expression

Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

solute carrier family 19 member 1

affects abundance

SLC19A1 protein affects the abundance of S-Adenosylhomocysteine

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

Sp1 transcription factor

multiple interactions

S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

TIMP metallopeptidase inhibitor 2

decreases expression

S-Adenosylhomocysteine results in decreased expression of TIMP2 protein

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

sinefungin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DNA methyltransferase 1

decreases activity

sinefungin results in decreased activity of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

decreases activity

sinefungin results in decreased activity of DNMT3A protein

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

stearoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 1

multiple interactions

stearoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

peroxisome proliferator activated receptor alpha

multiple interactions

stearoyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

stearoyl-coenzyme A binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

succinyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 4

affects hydrolysis

ACOT4 protein affects the hydrolysis of succinyl-coenzyme A

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

TNP-ATP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

purinergic receptor P2X 1

affects binding

TNP-ATP binds to P2rx1 protein

RGD

NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623

G

purinergic receptor P2X 2

multiple interactions

TNP-ATP binds to P2rx2 protein; TNP-ATP inhibits the reaction [ATP binds to P2rx2 protein] in transfected glial cells

RGD

NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891

G

purinergic receptor P2X 5

affects transport

TNP-ATP affects transport ion flux of P2rx5 receptor

RGD

NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
biological role	19785
biochemical role	19496
metabolite	19484
fundamental metabolite	14418
purine	6859
9H-purine	6681
adenine	1014
adenosines	765
2',3'-dideoxyadenosine	2
2',5'-dideoxy-5'-fluoroadenosine	0
2'-deoxy-2-fluoroadenosine	0
2-chloro-2',3'-dideoxyadenosine	0
2-fluoroadenosine	0
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine	190
3-iodo-4-aminobenzyl-5'-N-methylcarboxamidoadenosine	0
3-iodobenzyl-5'-N-methylcarboxamidoadenosine	11
5'-\{[2-(aminooxy)ethyl](methyl)sulfonio\}-5'-deoxyadenosine	0
5'-chloro-5'-deoxyadenosine	0
5'-dehydroadenosine	0
5'-deoxy-5'-(methylsulfinyl)adenosine	0
5'-deoxy-5'-fluoroadenosine	0
5'-deoxyadenosine	0
9-[(5E)-5,6,7-trideoxy-7-\{[(2,3-dihydroxy-5-nitrophenyl)carbonyl]amino\}-beta-D-ribo-hept-5-enofuranosyl]adenine	0
9-ribosylzeatin +	0
CGS-21680	39
L-adenosylselenohomocysteine	0
L-adenosylselenomethionine	0
N-(adenosin-N(6)-ylcarbonyl)threonine +	0
N-ethyl-1-(2-iodoadenin-9-yl)-1-deoxy-beta-D-ribofuranuronamide	0
N-ethyl-5'-carboxamidoadenosine	12
S-adenosyl-L-cysteine	0
S-adenosyl-L-homocysteine	28
S-adenosylglutathione(1-)	0
S-adenosylmethioninamine	0
adenosine +	400
adenosine 1-oxide	0
adenosine-5'-(N-butyl)carboxamide	0
adenosine-5'-(N-propyl)carboxamide	0
adenosylcobinamide guanosyl diphosphate	0
adenosylcobinamide phosphate	0
adenosylhopane	0
alpha-N-acetyllysine-N(6),N(6)-dimethyladenosine 5'-phosphomorpholidate	0
aminodeoxyfutalosine	0
clofarabine	21
cordycepin +	263
cordysinin B	0
cyclic N(6)-threonylcarbamoyladenosine	0
hydrocarbyladenosine +	10
nucleocidin	0
propionyl adenylate	0
puromycins +	31
sinefungin	2
succinyladenosine	0
thioadenosine +	28
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
main group element atom	19759
p-block element atom	19759
carbon group element atom	19708
carbon atom	19734
organic molecular entity	19705
heteroorganic entity	19459
organochalcogen compound	19222
organooxygen compound	19137
carbohydrates and carbohydrate derivatives	15269
carbohydrate	15284
carbohydrate derivative	14290
glycosyl compound	13035
N-glycosyl compound	5808
nucleoside	5662
ribonucleoside	1121
purine ribonucleoside	785
adenosines	765
2',3'-dideoxyadenosine	2
2',5'-dideoxy-5'-fluoroadenosine	0
2'-deoxy-2-fluoroadenosine	0
2-chloro-2',3'-dideoxyadenosine	0
2-fluoroadenosine	0
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine	190
3-iodo-4-aminobenzyl-5'-N-methylcarboxamidoadenosine	0
3-iodobenzyl-5'-N-methylcarboxamidoadenosine	11
5'-\{[2-(aminooxy)ethyl](methyl)sulfonio\}-5'-deoxyadenosine	0
5'-chloro-5'-deoxyadenosine	0
5'-dehydroadenosine	0
5'-deoxy-5'-(methylsulfinyl)adenosine	0
5'-deoxy-5'-fluoroadenosine	0
5'-deoxyadenosine	0
9-[(5E)-5,6,7-trideoxy-7-\{[(2,3-dihydroxy-5-nitrophenyl)carbonyl]amino\}-beta-D-ribo-hept-5-enofuranosyl]adenine	0
9-ribosylzeatin +	0
CGS-21680	39
L-adenosylselenohomocysteine	0
L-adenosylselenomethionine	0
N-(adenosin-N(6)-ylcarbonyl)threonine +	0
N-ethyl-1-(2-iodoadenin-9-yl)-1-deoxy-beta-D-ribofuranuronamide	0
N-ethyl-5'-carboxamidoadenosine	12
S-adenosyl-L-cysteine	0
S-adenosyl-L-homocysteine	28
S-adenosylglutathione(1-)	0
S-adenosylmethioninamine	0
adenosine +	400
adenosine 1-oxide	0
adenosine-5'-(N-butyl)carboxamide	0
adenosine-5'-(N-propyl)carboxamide	0
adenosylcobinamide guanosyl diphosphate	0
adenosylcobinamide phosphate	0
adenosylhopane	0
alpha-N-acetyllysine-N(6),N(6)-dimethyladenosine 5'-phosphomorpholidate	0
aminodeoxyfutalosine	0
clofarabine	21
cordycepin +	263
cordysinin B	0
cyclic N(6)-threonylcarbamoyladenosine	0
hydrocarbyladenosine +	10
nucleocidin	0
propionyl adenylate	0
puromycins +	31
sinefungin	2
succinyladenosine	0
thioadenosine +	28

paths to the root