Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acridines
go back to main search page
Accession:CHEBI:22213 term browser browse the term
Synonyms:xref_mesh: MESH:D000166


show annotations for term's descendants           Sort by:
 
acridines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP
ISO		 Acridines binds to and results in increased activity of AHR protein CTD PMID:21431309 PMID:28186253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor multiple interactions ISO Acridines inhibits the reaction [Androgens results in increased activity of AR protein] CTD PMID:28377212 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Casp3 caspase 3 increases activity ISO Acridines analog results in increased activity of CASP3 protein CTD PMID:15603970 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Acridines results in decreased activity of CES1 protein CTD PMID:23123248 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Acridines results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Acridines analog inhibits the reaction [CYP1A2 protein results in increased oxidation of vadimezan]
Acridines analog results in decreased activity of CYP1A2 protein		 CTD PMID:16120190 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Acridines metabolite results in increased expression of GADD45A protein; Acridines results in increased expression of GADD45A protein CTD PMID:31051210 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
3,6-diaminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Proflavine results in increased activity of ESR1 protein CTD PMID:30818834 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Proflavine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Proflavine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Proflavine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Proflavine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:30818834 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Proflavine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Proflavine inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tp53 tumor protein p53 increases activity ISO Proflavine results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
decreases activity		 ISO Aminacrine binds to ACHE protein
Aminacrine results in decreased activity of ACHE protein		 CTD PMID:31176713 PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G H2ax H2A.X variant histone decreases phosphorylation
multiple interactions		 ISO Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]		 CTD PMID:26928355 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
acridine-9(10H)-thione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk4 cyclin-dependent kinase 4 decreases activity ISO thioacridone results in decreased activity of CDK4 protein CTD PMID:15724842 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
amsacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Amsacrine analog binds to ALB protein; Amsacrine binds to ALB protein CTD PMID:10803926 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions ISO Amsacrine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Amsacrine CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to Amsacrine CTD PMID:10920913 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp2 caspase 2 increases splicing
increases expression		 ISO Amsacrine results in increased splicing of CASP2 mRNA
Amsacrine results in increased expression of CASP2 mRNA alternative form		 CTD PMID:14757846 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Amsacrine results in increased degradation of and results in decreased expression of CCNA2 protein CTD PMID:11774253 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Amsacrine results in increased degradation of and results in decreased expression of CCNB1 protein CTD PMID:11774253 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Amsacrine results in increased expression of CCNE1 protein CTD PMID:11774253 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine CTD PMID:16969495 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Amsacrine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Amsacrine binds to and results in decreased activity of KCNH2 protein CTD PMID:15148258 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases activity
affects response to substance
multiple interactions		 ISO Amsacrine results in increased activity of MAPK12 protein
MAPK12 protein affects the susceptibility to Amsacrine
[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine		 CTD PMID:21878638 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to Amsacrine CTD PMID:17575151 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Amsacrine results in decreased expression of MYC mRNA CTD PMID:11585056 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncl nucleolin affects response to substance ISO NCL protein affects the susceptibility to Amsacrine CTD PMID:16600179 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Amsacrine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Amsacrine results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Rad51 RAD51 recombinase affects response to substance ISO RAD51 protein affects the susceptibility to Amsacrine CTD PMID:16600179 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Amsacrine results in increased expression of RARB mRNA alternative form CTD PMID:17608728 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Amsacrine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Amsacrine results in increased expression of TNFRSF11B mRNA CTD PMID:11459812 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Amsacrine results in decreased expression of TNFSF11 mRNA CTD PMID:11459812 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
affects response to substance
decreases response to substance		 ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine; [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine
TOP2A protein modified form affects the susceptibility to Amsacrine
TOP2A gene mutant form results in decreased susceptibility to Amsacrine; TOP2A protein mutant form results in decreased susceptibility to Amsacrine		 CTD PMID:1651812 PMID:10727526 PMID:11470519 PMID:11676865 PMID:12569090 More... NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top2b DNA topoisomerase II beta decreases response to substance ISO TOP2B protein mutant form results in decreased susceptibility to Amsacrine CTD PMID:15322234 PMID:16239602 PMID:16549872 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Tp53 tumor protein p53 increases activity
increases glutathionylation
multiple interactions
increases expression		 ISO Amsacrine analog results in increased activity of TP53 protein
Amsacrine results in increased glutathionylation of TP53 protein
Amsacrine results in increased stability of and results in increased activity of TP53 protein
Amsacrine results in increased expression of TP53 protein		 CTD PMID:11774253 PMID:12082016 PMID:16177561 PMID:17555331 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Amsacrine results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr 6:27,818,327...27,827,030 JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Amsacrine results in decreased expression of UBE2C mRNA CTD PMID:17374387 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Wrn WRN RecQ like helicase increases response to substance ISO WRN gene mutant form results in increased susceptibility to Amsacrine CTD PMID:10725663 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
clomacran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clomacran inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
ethacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Ethacridine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Ethacridine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions		 ISO ABCB1 protein results in increased transport of Quinacrine
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of Quinacrine]		 CTD PMID:16581945 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Quinacrine inhibits the reaction [AGT protein results in increased metabolism of and results in increased abundance of Arachidonic Acid] CTD PMID:16257180 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
increases expression
multiple interactions		 ISO BAX protein results in increased susceptibility to Quinacrine
Quinacrine results in increased expression of BAX mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of BAX mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of BAX protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of BAX protein]; mithramycin A inhibits the reaction [Quinacrine results in increased expression of BAX mRNA]; mithramycin A inhibits the reaction [Quinacrine results in increased expression of BAX protein]; Quinacrine promotes the reaction [SP1 protein binds to BAX promoter]; Quinacrine results in increased expression of and affects the localization of BAX protein		 CTD PMID:16177561 PMID:28867437 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase decreases expression
multiple interactions		 ISO Quinacrine results in decreased expression of BTRC protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased expression of BTRC protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of BAX protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]; MIR183 mRNA affects the reaction [Quinacrine results in decreased expression of BTRC protein]; Quinacrine results in decreased expression of and results in decreased stability of BTRC mRNA		 CTD PMID:28867437 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity		 ISO Quinacrine results in increased cleavage of CASP3 protein
GSK3B protein affects the reaction [Quinacrine results in increased activity of CASP3 protein]		 CTD PMID:28720477 PMID:28867437 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Quinacrine results in increased cleavage of CASP9 protein CTD PMID:28867437 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO Quinacrine results in decreased expression of CCND1 protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of CCND1 protein]		 CTD PMID:28720477 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Quinacrine results in decreased expression of CDKN1A mRNA CTD PMID:32910239 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 increases expression
multiple interactions		 ISO Quinacrine results in increased expression of CSNK1A1 protein
GSK3B protein affects the reaction [Quinacrine results in increased expression of CSNK1A1 protein]		 CTD PMID:28720477 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO GSK3B protein affects the reaction [Quinacrine results in decreased expression of CTNNB1 protein] CTD PMID:28720477 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression		 EXP Quinacrine binds to and results in decreased activity of CYP2E1 protein
Quinacrine results in decreased expression of CYP2E1 protein		 CTD PMID:18754103 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Quinacrine CTD PMID:16581945 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Foxp3 forkhead box P3 increases expression
multiple interactions		 ISO Quinacrine results in increased expression of FOXP3 mRNA; Quinacrine results in increased expression of FOXP3 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of FOXP3 protein]; FOXP3 protein affects the reaction [Quinacrine results in decreased expression of BTRC protein]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of MIR183 mRNA]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]		 CTD PMID:28867437 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression
multiple interactions		 ISO Quinacrine results in decreased expression of GLI1 protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]		 CTD PMID:28720477 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions		 ISO Quinacrine results in increased expression of GSK3B mRNA
GSK3B protein affects the reaction [Quinacrine results in decreased expression of CCND1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of CTNNB1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]; GSK3B protein affects the reaction [Quinacrine results in decreased expression of MYC protein]; GSK3B protein affects the reaction [Quinacrine results in increased activity of CASP3 protein]; GSK3B protein affects the reaction [Quinacrine results in increased expression of CSNK1A1 protein]; Quinacrine results in increased expression of and results in decreased phosphorylation of GSK3B protein		 CTD PMID:28720477 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Quinacrine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO Quinacrine results in decreased phosphorylation of MAPK1 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:28867437 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO Quinacrine results in decreased phosphorylation of MAPK3 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:28867437 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir183 microRNA 183 multiple interactions
increases expression		 ISO FOXP3 protein affects the reaction [Quinacrine results in increased expression of MIR183 mRNA]; MIR183 mRNA affects the reaction [Quinacrine results in decreased expression of BTRC protein]; MIR183 mRNA affects the reaction [Quinacrine results in increased expression of SP1 protein] CTD PMID:28867437 NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions		 ISO Quinacrine results in decreased expression of MYC protein
GSK3B protein affects the reaction [Quinacrine results in decreased expression of MYC protein]		 CTD PMID:28720477 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO Quinacrine binds to and results in decreased activity of NQO2 protein CTD PMID:15078100 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Otc ornithine transcarbamylase multiple interactions EXP Quinacrine inhibits the reaction [PRL protein results in increased activity of OTC protein]; Quinacrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Quinacrine results in increased cleavage of PARP1 protein CTD PMID:28867437 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prl prolactin multiple interactions EXP Quinacrine inhibits the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; BTRC protein inhibits the reaction [Quinacrine results in increased expression of SP1 protein]; FOXP3 protein affects the reaction [Quinacrine results in increased expression of SP1 protein]; MIR183 mRNA affects the reaction [Quinacrine results in increased expression of SP1 protein]; Quinacrine promotes the reaction [SP1 protein binds to BAX promoter]; Quinacrine results in increased expression of and results in increased stability of SP1 protein CTD PMID:28867437 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions		 ISO Quinacrine results in increased activity of TP53 protein
Quinacrine results in increased stability of and results in increased activity of TP53 protein		 CTD PMID:12082016 PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
tacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Tacrine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions		 ISO
EXP		 Tacrine results in decreased activity of ACHE protein
Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ALB protein affects the reaction [Tacrine results in decreased activity of ACHE protein]
Tacrine analog results in decreased activity of ACHE protein; Tacrine results in decreased activity of ACHE protein		 CTD PMID:2606156 PMID:9228650 PMID:12589378 PMID:15990178 PMID:18571635 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I increases expression EXP Tacrine results in increased expression of ADCYAP1R1 mRNA CTD PMID:12832660 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Tacrine results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 Tacrine inhibits the reaction [Staurosporine results in increased expression of BAX protein]
Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]		 CTD PMID:12414117 PMID:12579951 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Tacrine results in decreased activity of BCHE protein CTD PMID:9228650 PMID:18656440 PMID:29992664 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Tacrine results in increased expression of BCL2 protein CTD PMID:12579951 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein] CTD PMID:26408985 PMID:31077737 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:31077737 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Tacrine results in decreased expression of CCL5 mRNA CTD PMID:12832660 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Tacrine results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity
affects binding		 ISO Tacrine analog results in decreased activity of CES1 protein
Tacrine binds to CES1 protein		 CTD PMID:12725862 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Tacrine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chat choline O-acetyltransferase increases expression ISO Tacrine results in increased expression of CHAT protein CTD PMID:15990178 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP
ISO		 Tacrine inhibits the reaction [telenzepine binds to CHRM1 protein]
Tacrine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]		 CTD PMID:2606156 PMID:16439611 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions EXP Tacrine inhibits the reaction [otenzepad binds to CHRM2 protein] CTD PMID:2606156 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
increases expression		 ISO Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Tacrine results in increased expression of CHRNA4 protein
Mecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNA4 protein]		 CTD PMID:8930989 PMID:15733544 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases expression		 ISO Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Tacrine results in increased expression of CHRNB2 protein
Mecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNB2 protein]		 CTD PMID:8930989 PMID:15733544 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] CTD PMID:31077737 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cspp1 centrosome and spindle pole associated protein 1 increases expression EXP Tacrine results in increased expression of CSPP1 mRNA CTD PMID:12832660 NCBI chr 5:9,077,161...9,192,402
Ensembl chr 5:9,077,161...9,193,377 		JBrowse link
G Cwf19l2 CWF19 like cell cycle control factor 2 increases expression EXP Tacrine results in increased expression of CWF19L2 mRNA CTD PMID:12832660 NCBI chr 6:290,148...356,636
Ensembl chr 6:281,685...356,604 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
affects metabolic processing
multiple interactions		 EXP
ISO		 Tacrine analog results in increased expression of CYP1A1 protein; Tacrine results in increased expression of CYP1A1 mRNA; Tacrine results in increased expression of CYP1A1 protein
CYP1A1 protein affects the metabolism of Tacrine
Tacrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:12832660 PMID:15258105 PMID:18493746 PMID:20533758 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
decreases activity
affects metabolic processing		 ISO
EXP		 Chloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; NADP promotes the reaction [Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; Tacrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Tacrine results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of Tacrine		 CTD PMID:7946932 PMID:15258105 PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Tacrine analog results in increased expression of CYP2B1 protein; Tacrine results in increased expression of CYP2B1 protein CTD PMID:20533758 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases response to substance		 EXP
ISO		 Tacrine analog results in increased expression of CYP3A2 protein; Tacrine results in increased expression of CYP3A2 protein
CYP3A4 protein results in increased susceptibility to Tacrine		 CTD PMID:20533758 PMID:21540358 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Tacrine results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression EXP Tacrine results in increased expression of DLG2 mRNA CTD PMID:12832660 NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475 		JBrowse link
G Dnah8 dynein, axonemal, heavy chain 8 increases expression EXP Tacrine results in increased expression of DNAH8 mRNA CTD PMID:12832660 NCBI chr20:8,692,939...8,946,780
Ensembl chr20:8,692,963...8,946,772 		JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression EXP Tacrine results in increased expression of DYNC1LI2 mRNA CTD PMID:12832660 NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Tacrine results in increased expression of FOS protein
zonisamide inhibits the reaction [Tacrine results in increased expression of FOS protein]		 CTD PMID:18693129 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression EXP Tacrine results in increased expression of GABRA4 mRNA CTD PMID:12832660 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gata3 GATA binding protein 3 increases expression EXP Tacrine results in increased expression of GATA3 mRNA CTD PMID:12832660 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein] CTD PMID:26408985 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Tacrine results in increased expression of GSTM2 mRNA CTD PMID:12832660 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Tacrine results in increased expression of HGF mRNA CTD PMID:12832660 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Tacrine analog results in increased expression of HMOX1 protein; Tacrine results in increased expression of HMOX1 protein CTD PMID:20533758 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP Tacrine inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:2606156 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Ibsp integrin-binding sialoprotein increases expression EXP Tacrine results in increased expression of IBSP mRNA CTD PMID:12832660 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] CTD PMID:31077737 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein] CTD PMID:31077737 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein] CTD PMID:31077737 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Tacrine results in increased expression of ITGAM mRNA CTD PMID:12832660 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Tacrine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Tacrine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347 		JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 increases expression EXP Tacrine results in increased expression of KLK1C9 mRNA CTD PMID:12832660 NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245 		JBrowse link
G Lepr leptin receptor increases expression EXP Tacrine results in increased expression of LEPR mRNA CTD PMID:12832660 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mybpc1 myosin binding protein C1 decreases expression EXP Tacrine results in decreased expression of MYBPC1 mRNA CTD PMID:12832660 NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957 		JBrowse link
G Neurod1 neuronal differentiation 1 increases expression EXP Tacrine results in increased expression of NEUROD1 mRNA CTD PMID:12832660 NCBI chr 3:64,360,222...64,363,526
Ensembl chr 3:64,359,395...64,363,649 		JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP Tacrine results in increased expression of NOS1 mRNA CTD PMID:9500967 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:31077737 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 increases expression EXP Tacrine results in increased expression of NPY5R mRNA CTD PMID:12832660 NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases activity		 ISO Tacrine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
Tacrine results in decreased activity of NQO1 protein		 CTD PMID:29281794 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 decreases activity
multiple interactions		 ISO Tacrine results in decreased activity of NQO2 protein
Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of amodiaquine quinoneimine]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]		 CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein CTD PMID:31077737 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 Tacrine results in increased expression of PTGS2 protein
Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]		 CTD PMID:9500967 PMID:31077737 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 increases expression EXP Tacrine results in increased expression of SCN1A mRNA CTD PMID:12832660 NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tacrine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Tacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tacrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Tacrine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tacrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 increases expression EXP Tacrine results in increased expression of SLC6A1 mRNA CTD PMID:12832660 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Snca synuclein alpha decreases expression EXP Tacrine results in decreased expression of SNCA mRNA CTD PMID:12832660 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Syn2 synapsin II increases expression EXP Tacrine results in increased expression of SYN2 mRNA CTD PMID:12832660 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein] CTD PMID:31077737 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf4 TNF superfamily member 4 increases expression EXP Tacrine results in increased expression of TNFSF4 mRNA CTD PMID:12832660 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA]; Tacrine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] CTD PMID:12414117 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    chemical entity 20071
      atom 20071
        nonmetal atom 19963
          nitrogen atom 19043
            nitrogen molecular entity 19043
              organonitrogen compound 18842
                organonitrogen heterocyclic compound 17995
                  dibenzopyridine 155
                    acridines 122
                      (9-chloro-5,6,7,8-tetrahydroacridin-3-yl)-(4-methyl-1-piperidinyl)methanone 0
                      1,2,3,4-tetrahydroacridine-9-carboxylic acid (2-oxo-2-thiophen-2-ylethyl) ester 0
                      1,2,3,4-tetrahydroacridine-9-carboxylic acid [2-(3-chloro-4-methoxyanilino)-2-oxoethyl] ester 0
                      1,3,4,10-Tetrahydro-9(2H)-acridinone 0
                      1,3,5-Trihydroxy-10-methylacridone 0
                      1,3-dichloro-7-hydroxy-9,9-dimethyl-9H-acridin-2-one 0
                      1,3-dihydroxy-N-methylacridone 0
                      1,4-dimethoxy-10H-acridine-9-thione 0
                      1,5-Dihydroxy-2,3-dimethoxy-10-methyl-9-acridone 0
                      1-Hydroxy-10-methylacridone 0
                      1-Hydroxy-3-methoxy-10-methylacridone 0
                      1-Hydroxy-4-[5-hydroxy-2,2-dimethyl-10-(2-methylbut-3-en-2-yl)-8-oxo-2H,3H,4H,8H-pyrano[3,2-g]chromen-4-yl]-3,5,6-trimethoxy-9,10-dihydroacridin-9-one 0
                      1-Hydroxyrutacridone epoxide 0
                      1-methoxy-10H-acridin-9-one 0
                      10-(3-aminopropyl)-3,4-dimethyl-9-acridinone 0
                      10-Methyl-9(10H)-acridone 0
                      10-[3-(dibutylamino)-2-hydroxypropyl]-9-acridinone 0
                      2',2'-Dimethyl(pyrano-5',6':3:4)-1,5-dihydroxy-6-methoxy-10-methylacridone 0
                      2-Aminoacridone 0
                      2-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)thio]-N-(3-methoxypropyl)acetamide 0
                      2-[5,10-Dihydroxy-2-(2-hydroxypropan-2-yl)-11-methyl-6-oxo-1H,2H,6H,11H-furo[2,3-c]acridin-1-yl]-1-hydroxy-3,5,6-trimethoxy-9,10-dihydroacridin-9-one 0
                      2-[[6-[(5-chloro-2,4-dimethoxyanilino)-oxomethyl]-1,2,3,4-tetrahydroacridin-9-yl]thio]acetic acid 0
                      2-tert-butyl-9-methyl-1,2,3,4-tetrahydroacridine 0
                      20-Hydroxyrutacridone epoxide 0
                      3,9,11-Trichloro-5,6-dihydro-7-[1-hydroxy-2-[1-piperidyl]ethyl]benz[c]acridine 0
                      3-pyrrolidin-1-yl-N-[6-(3-pyrrolidin-1-ylpropionylamino)acridin-3-yl]propionamide 0
                      4-(9-acridinylamino)-1,5-dimethyl-2-phenyl-3-pyrazolone 0
                      4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid (2-anilino-2-oxoethyl) ester 0
                      4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid [2-(4-acetylanilino)-2-oxoethyl] ester 0
                      4-[(3,3-Dimethyloxiran-2-yl)(hydroxy)methyl]-1-hydroxy-3,5,6-trimethoxy-10-methyl-9,10-dihydroacridin-9-one 0
                      4-[(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-1,2,3,10-tetrahydroacridine-9-carboxylic acid 0
                      5-Hydroxynoracronycine 0
                      5-Methoxynoracronycine 0
                      9-(1H-indol-3-yl)acridine 0
                      9-Amino-1,2,3,4-tetrahydro-acridinium 0
                      9-amino-1,2,3,4-tetrahydroacridin-1-ol 0
                      9-amino-N-(2-morpholin-4-ylethyl)acridine-4-carboxamide 0
                      Acrimarine I 0
                      Acrimarine J 0
                      Acrimarine N 0
                      Alkaloid A6 0
                      Arborinine 0
                      Atalanine 0
                      Atalaphylline 0
                      Buntanine 0
                      Citbismine B 0
                      Citbismine C 0
                      Citbismine E 0
                      Citpressine I 0
                      Citpressine II 0
                      Citracridone I 0
                      Citrusinine I 0
                      Dihydroxycitracridone I 0
                      Dioxinoacrimarine A 0
                      Evoprenine 0
                      Evoxanthidine 0
                      Furofoline I 0
                      Gravacridonediol methyl ether 0
                      Gravacridonetriol 0
                      Gravacridonol 0
                      Hallacridone 0
                      Honyumine 0
                      ICR-170 0
                      Junosine 0
                      LSM-18565 0
                      Margrapine A 0
                      Marshmine 0
                      Melicopicine 0
                      Melicopidine 0
                      Melicopine 0
                      N'-(9-acridinyl)-2-(3-methylphenoxy)acetohydrazide 0
                      N'-(9-acridinyl)-2-hydroxybenzohydrazide 0
                      N,N'-(9-\{[4-(dimethylamino)phenyl]amino\}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide) + 0
                      N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine + 0
                      N-(3-fluorophenyl)-2-(9-oxo-10-acridinyl)acetamide 0
                      N-[(10-methyl-9,10-dihydroacridin-9-yl)carbonyl]-beta-alanine 0
                      N-[4-(9-acridinylmethyl)-3-methoxyphenyl]methanesulfonamide 0
                      Neoacrimarine A 0
                      Neoacrimarine B 0
                      Neoacrimarine G 0
                      Neoacrimarine K 0
                      Rutacridone 0
                      Rutacridone epoxide 0
                      Rutagravine 0
                      acridine + 30
                      acridine-9(10H)-thione 1
                      acridone + 0
                      aminoacridines + 17
                      amsacrine 28
                      asulacrine 0
                      bucricaine 0
                      clomacran 1
                      cridanimod 0
                      dimetacrine 0
                      ethacridine 1
                      nitracrine 0
                      quinacrine + 30
                      tacrine + 65
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            organic molecule 19844
                              organic cyclic compound 19605
                                organic heterocyclic compound 18890
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15623
                                      dibenzopyridine 155
                                        acridines 122
                                          (9-chloro-5,6,7,8-tetrahydroacridin-3-yl)-(4-methyl-1-piperidinyl)methanone 0
                                          1,2,3,4-tetrahydroacridine-9-carboxylic acid (2-oxo-2-thiophen-2-ylethyl) ester 0
                                          1,2,3,4-tetrahydroacridine-9-carboxylic acid [2-(3-chloro-4-methoxyanilino)-2-oxoethyl] ester 0
                                          1,3,4,10-Tetrahydro-9(2H)-acridinone 0
                                          1,3,5-Trihydroxy-10-methylacridone 0
                                          1,3-dichloro-7-hydroxy-9,9-dimethyl-9H-acridin-2-one 0
                                          1,3-dihydroxy-N-methylacridone 0
                                          1,4-dimethoxy-10H-acridine-9-thione 0
                                          1,5-Dihydroxy-2,3-dimethoxy-10-methyl-9-acridone 0
                                          1-Hydroxy-10-methylacridone 0
                                          1-Hydroxy-3-methoxy-10-methylacridone 0
                                          1-Hydroxy-4-[5-hydroxy-2,2-dimethyl-10-(2-methylbut-3-en-2-yl)-8-oxo-2H,3H,4H,8H-pyrano[3,2-g]chromen-4-yl]-3,5,6-trimethoxy-9,10-dihydroacridin-9-one 0
                                          1-Hydroxyrutacridone epoxide 0
                                          1-methoxy-10H-acridin-9-one 0
                                          10-(3-aminopropyl)-3,4-dimethyl-9-acridinone 0
                                          10-Methyl-9(10H)-acridone 0
                                          10-[3-(dibutylamino)-2-hydroxypropyl]-9-acridinone 0
                                          2',2'-Dimethyl(pyrano-5',6':3:4)-1,5-dihydroxy-6-methoxy-10-methylacridone 0
                                          2-Aminoacridone 0
                                          2-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)thio]-N-(3-methoxypropyl)acetamide 0
                                          2-[5,10-Dihydroxy-2-(2-hydroxypropan-2-yl)-11-methyl-6-oxo-1H,2H,6H,11H-furo[2,3-c]acridin-1-yl]-1-hydroxy-3,5,6-trimethoxy-9,10-dihydroacridin-9-one 0
                                          2-[[6-[(5-chloro-2,4-dimethoxyanilino)-oxomethyl]-1,2,3,4-tetrahydroacridin-9-yl]thio]acetic acid 0
                                          2-tert-butyl-9-methyl-1,2,3,4-tetrahydroacridine 0
                                          20-Hydroxyrutacridone epoxide 0
                                          3,9,11-Trichloro-5,6-dihydro-7-[1-hydroxy-2-[1-piperidyl]ethyl]benz[c]acridine 0
                                          3-pyrrolidin-1-yl-N-[6-(3-pyrrolidin-1-ylpropionylamino)acridin-3-yl]propionamide 0
                                          4-(9-acridinylamino)-1,5-dimethyl-2-phenyl-3-pyrazolone 0
                                          4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid (2-anilino-2-oxoethyl) ester 0
                                          4-(thiophen-2-ylmethylidene)-2,3-dihydro-1H-acridine-9-carboxylic acid [2-(4-acetylanilino)-2-oxoethyl] ester 0
                                          4-[(3,3-Dimethyloxiran-2-yl)(hydroxy)methyl]-1-hydroxy-3,5,6-trimethoxy-10-methyl-9,10-dihydroacridin-9-one 0
                                          4-[(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-1,2,3,10-tetrahydroacridine-9-carboxylic acid 0
                                          5-Hydroxynoracronycine 0
                                          5-Methoxynoracronycine 0
                                          9-(1H-indol-3-yl)acridine 0
                                          9-Amino-1,2,3,4-tetrahydro-acridinium 0
                                          9-amino-1,2,3,4-tetrahydroacridin-1-ol 0
                                          9-amino-N-(2-morpholin-4-ylethyl)acridine-4-carboxamide 0
                                          Acrimarine I 0
                                          Acrimarine J 0
                                          Acrimarine N 0
                                          Alkaloid A6 0
                                          Arborinine 0
                                          Atalanine 0
                                          Atalaphylline 0
                                          Buntanine 0
                                          Citbismine B 0
                                          Citbismine C 0
                                          Citbismine E 0
                                          Citpressine I 0
                                          Citpressine II 0
                                          Citracridone I 0
                                          Citrusinine I 0
                                          Dihydroxycitracridone I 0
                                          Dioxinoacrimarine A 0
                                          Evoprenine 0
                                          Evoxanthidine 0
                                          Furofoline I 0
                                          Gravacridonediol methyl ether 0
                                          Gravacridonetriol 0
                                          Gravacridonol 0
                                          Hallacridone 0
                                          Honyumine 0
                                          ICR-170 0
                                          Junosine 0
                                          LSM-18565 0
                                          Margrapine A 0
                                          Marshmine 0
                                          Melicopicine 0
                                          Melicopidine 0
                                          Melicopine 0
                                          N'-(9-acridinyl)-2-(3-methylphenoxy)acetohydrazide 0
                                          N'-(9-acridinyl)-2-hydroxybenzohydrazide 0
                                          N,N'-(9-\{[4-(dimethylamino)phenyl]amino\}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide) + 0
                                          N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine + 0
                                          N-(3-fluorophenyl)-2-(9-oxo-10-acridinyl)acetamide 0
                                          N-[(10-methyl-9,10-dihydroacridin-9-yl)carbonyl]-beta-alanine 0
                                          N-[4-(9-acridinylmethyl)-3-methoxyphenyl]methanesulfonamide 0
                                          Neoacrimarine A 0
                                          Neoacrimarine B 0
                                          Neoacrimarine G 0
                                          Neoacrimarine K 0
                                          Rutacridone 0
                                          Rutacridone epoxide 0
                                          Rutagravine 0
                                          acridine + 30
                                          acridine-9(10H)-thione 1
                                          acridone + 0
                                          aminoacridines + 17
                                          amsacrine 28
                                          asulacrine 0
                                          bucricaine 0
                                          clomacran 1
                                          cridanimod 0
                                          dimetacrine 0
                                          ethacridine 1
                                          nitracrine 0
                                          quinacrine + 30
                                          tacrine + 65
paths to the root