acetylcysteine - Ontology Report - Rat Genome Database

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of A1BG mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of A1BG mRNA]

NCBI chr 7:102,294,805...102,298,522
Ensembl chr 7:102,294,797...102,298,522

Abca1

ATP binding cassette subfamily A member 1

multiple interactions

Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased methylation of ABCA1 promoter]

PMID:31150806

NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015

Abcb1a

ATP binding cassette subfamily B member 1A

multiple interactions

Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ABCB1]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]

PMID:10636889 PMID:18474546 PMID:22914566 PMID:23867903 PMID:25824409

NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515

Abcc1

ATP binding cassette subfamily C member 1

multiple interactions

Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC1 protein]; Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]]

PMID:11820781 PMID:15473893 PMID:22914566 PMID:23867903

NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196

Abcc2

ATP binding cassette subfamily C member 2

multiple interactions

Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA]

PMID:22914566 PMID:23867903

NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252

Abcc3

ATP binding cassette subfamily C member 3

multiple interactions

Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC3 protein]

PMID:11820781

NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109

Abcg1

ATP binding cassette subfamily G member 1

decreases expression

Acetylcysteine results in decreased expression of ABCG1 mRNA

NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489

Abcg4

ATP binding cassette subfamily G member 4

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA]

NCBI chr 8:48,604,915...48,626,219
Ensembl chr 8:48,606,403...48,619,592

Abl1

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of ABL1 protein]

PMID:16481037

NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388

Ache

acetylcholinesterase

multiple interactions
affects response to substance

[Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Cadmium results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein]
ACHE protein affects the susceptibility to Acetylcysteine
Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of ACHE mRNA alternative form]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]

PMID:20399762 PMID:20688495 PMID:26769589 PMID:27087133 PMID:27163631 PMID:28499986 PMID:29253600 PMID:30639957 PMID:31173782

NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753

Acp3

acid phosphatase 3

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACP3 mRNA

NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077

Acsm5

acyl-CoA synthetase medium-chain family member 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSM5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ACSM5 mRNA]

NCBI chr 1:189,240,955...189,270,422
Ensembl chr 1:189,233,141...189,272,172

Acss1

acyl-CoA synthetase short-chain family member 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSS1 mRNA

NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293

Acta2

actin alpha 2, smooth muscle

multiple interactions

Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]

PMID:16757516 PMID:21134390 PMID:32659284

NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394

Adam33

ADAM metallopeptidase domain 33

multiple interactions

Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ADAM33 mRNA]

PMID:29753051

NCBI chr 3:123,595,018...123,607,549
Ensembl chr 3:123,595,560...123,607,352

Adgrb2

adhesion G protein-coupled receptor B2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB2 mRNA

NCBI chr 5:148,168,530...148,231,587
Ensembl chr 5:148,193,710...148,231,587

Adgrb3

adhesion G protein-coupled receptor B3

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB3 mRNA

NCBI chr 9:31,280,623...32,022,535
Ensembl chr 9:31,281,316...32,019,205

Adh1

alcohol dehydrogenase 1 (class I)

multiple interactions

Acetylcysteine inhibits the reaction [Ethanol results in increased expression of ADH1 mRNA]

PMID:20705415

NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857

Adipoq

adiponectin, C1Q and collagen domain containing

multiple interactions

Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]]

PMID:17471172 PMID:21912612

NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488

Adipor2

adiponectin receptor 2

multiple interactions

Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]]

PMID:21912612

NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894

Agt

angiotensinogen

multiple interactions

Acetylcysteine inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Acetylcysteine inhibits the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species]

PMID:15849355 PMID:30703374

NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433

Agtr1a

angiotensin II receptor, type 1a

multiple interactions

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]

PMID:23603059

NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077

Ahr

aryl hydrocarbon receptor

increases expression
multiple interactions

Acetylcysteine results in increased expression of AHR protein
Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of and affects the localization of AHR protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1A enhancer]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1B enhancer]

PMID:18022818 PMID:21569840 PMID:31551408

NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464

Aifm1

apoptosis inducing factor, mitochondria associated 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]
Acetylcysteine inhibits the reaction [bisphenol A affects the localization of AIFM1 protein]
Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of AIFM1 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein]

PMID:18034189 PMID:18412143 PMID:18506790 PMID:18951928 PMID:19679660 PMID:21741372 PMID:27189055 PMID:31518672

NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087

Aimp1

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

Acetylcysteine results in decreased expression of AIMP1 mRNA

NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378

Akr1b8

aldo-keto reductase family 1, member B8

multiple interactions

Acetylcysteine inhibits the reaction [arsenite results in increased expression of AKR1B8 protein]

NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657

Akr1c3

aldo-keto reductase family 1, member C3

multiple interactions

Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA]

PMID:18829485 PMID:21787718

NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021

Akt1

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of and affects the localization of AKT1 protein]; Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [divinyl sulfone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Morpholines analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [N-arachidonoylalanine results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [oenothein B results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [synaptamide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]
Acetylcysteine inhibits the reaction [cadmium acetate results in decreased expression of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AKT1 mRNA]

PMID:12168106 PMID:12614848 PMID:16137721 PMID:16731823 PMID:21055460 PMID:21195169 PMID:21787718 PMID:22427991 PMID:22867088 PMID:23000059 PMID:23159718 PMID:23948867 PMID:24299490 PMID:24449419 PMID:24489685 PMID:24582688 PMID:24875536 PMID:24933620 PMID:25199686 PMID:25471227 PMID:25939952 PMID:25944616 PMID:26514923 PMID:26804764 PMID:26942697 PMID:27106530 PMID:27117918 PMID:27411387 PMID:27658547 PMID:28087840 PMID:28600122 PMID:29604266 PMID:30265530 PMID:30452899 PMID:30797898 PMID:30871965 PMID:31068539 PMID:31157476 PMID:32305283

NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258

Alad

aminolevulinate dehydratase

multiple interactions

Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]]

PMID:16959597

NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346

Alb

albumin

multiple interactions

Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in decreased expression of MFN2 protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in increased abundance of Hydrogen Peroxide]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [Mustard Gas results in increased expression of ALB protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]

PMID:11428623 PMID:20804811 PMID:24485406 PMID:27997345

NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863

Aldh2

aldehyde dehydrogenase 2 family member

multiple interactions

Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]

PMID:17585900

NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752

Alk

ALK receptor tyrosine kinase

multiple interactions

Acetylcysteine affects the phosphorylation of and affects the activity of ALK protein mutant form

PMID:19503098

NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775

Amacr

alpha-methylacyl-CoA racemase

multiple interactions

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA]

NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326

Ang

angiogenin

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of ANG protein]

NCBI chr15:28,022,926...28,028,636

Angpt1

angiopoietin 1

decreases secretion

Acetylcysteine results in decreased secretion of ANGPT1 protein

PMID:19622383

NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206

Angptl4

angiopoietin-like 4

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079

Ankrd29

ankyrin repeat domain 29

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANKRD29 mRNA

NCBI chr18:3,673,915...3,676,187
Ensembl chr18:3,673,915...3,676,188

Aoc1

amine oxidase, copper containing 1

multiple interactions

Acetylcysteine inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]

PMID:20885979

NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584

Apaf1

apoptotic peptidase activating factor 1

multiple interactions

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]

PMID:15877105 PMID:19477266

NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192

Apex1

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA]

PMID:12231548 PMID:17938202

NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082

Apex2

apurinic/apyrimidinic endodeoxyribonuclease 2

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]
Acetylcysteine results in decreased expression of APEX2 mRNA

PMID:26332274

NCBI chr X:23,146,085...23,166,676
Ensembl chr X:23,146,085...23,166,675

Aph1b

aph-1 homolog B, gamma secretase subunit

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of APH1B mRNA

NCBI chr 8:72,508,008...72,598,921
Ensembl chr 8:72,476,425...72,629,265

App

amyloid beta precursor protein

multiple interactions

Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of NLRP3 protein]

PMID:12684028 PMID:28004443

NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858

Aqp2

aquaporin 2

increases expression

Acetylcysteine results in increased expression of AQP2 protein

PMID:23183129

NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165

androgen receptor

multiple interactions

Acetylcysteine inhibits the reaction [SOD2 protein affects the activity of AR protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR mRNA]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR protein]

PMID:16928829 PMID:18829485

NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026

Arl13a

ADP ribosylation factor like GTPase 13A

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARL13A mRNA

NCBI chr X:105,010,943...105,039,720
Ensembl chr X:105,011,489...105,037,801

Arnt

aryl hydrocarbon receptor nuclear translocator

multiple interactions

Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]

PMID:16880289

NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179

Arntl

aryl hydrocarbon receptor nuclear translocator-like

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARNTL mRNA

NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465

Arrdc3

arrestin domain containing 3

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARRDC3 mRNA

NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069

Art4

ADP-ribosyltransferase 4

decreases expression

Acetylcysteine results in decreased expression of ART4 mRNA

NCBI chr 4:170,830,851...170,841,187
Ensembl chr 4:170,830,851...170,841,187

Asns

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASNS mRNA

NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163

Astl

astacin like metalloendopeptidase

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASTL mRNA

NCBI chr 3:119,783,717...119,799,450
Ensembl chr 3:119,783,717...119,799,450

Atf2

activating transcription factor 2

multiple interactions

Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein]
Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]

PMID:19654923 PMID:22288910

NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951

Atf3

activating transcription factor 3

multiple interactions

Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of and affects the localization of ATF3 protein]

PMID:25531190

NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632

Atf4

activating transcription factor 4

multiple interactions
decreases expression
increases expression

Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]
Acetylcysteine results in decreased expression of ATF4 protein
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of ATF4 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]
Acetylcysteine results in increased expression of ATF4 protein

PMID:15788408 PMID:19722195 PMID:21266191 PMID:24291486 PMID:25451595 PMID:25568320 PMID:27484784 PMID:27634458 PMID:27816613 PMID:28754437 PMID:31330229 PMID:32578922

NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772

Atf6

activating transcription factor 6

multiple interactions

Acetylcysteine results in increased metabolism of and results in increased activity of ATF6 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF6 protein]

PMID:18077580 PMID:19722195 PMID:21198628 PMID:21911445 PMID:24291486 PMID:25451595 PMID:31330229

NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443

Atg10

autophagy related 10

multiple interactions

Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA]

PMID:24614525

NCBI chr 2:19,853,546...20,152,918
Ensembl chr 2:19,853,546...20,152,884

Atg12

autophagy related 12

multiple interactions

Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG12 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG12 mRNA]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]

PMID:20543569 PMID:24614525 PMID:29307831 PMID:30205151

NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126

Atg16l1

autophagy related 16-like 1

multiple interactions

Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG16L1 protein]

PMID:30205151

NCBI chr 9:94,879,876...94,915,231
Ensembl chr 9:94,879,745...94,915,228

Atg4a

autophagy related 4A, cysteine peptidase

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ATG4A protein]

PMID:29179951

NCBI chr X:112,328,907...112,403,157

Atg5

autophagy related 5

multiple interactions

Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG5 mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]

PMID:20543569 PMID:24614525 PMID:28600122 PMID:29307831 PMID:30205151

NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140

Atg7

autophagy related 7

multiple interactions

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATG7 mRNA]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG7 mRNA]

PMID:29247770 PMID:29307831 PMID:30205151 PMID:31319114

NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124

Atm

ATM serine/threonine kinase

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein]; Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of ATM protein modified form]; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]
Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATM protein]
Acetylcysteine results in increased phosphorylation of ATM protein

PMID:15489221 PMID:23274516 PMID:24792323 PMID:26451628 PMID:31168028 PMID:31715134 PMID:32142722

NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045

Atp1a1

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein]

PMID:10506578

NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023

Atp2a2

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression
multiple interactions

Acetylcysteine results in increased expression of ATP2A2 mRNA
Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of ATP2A2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]

PMID:10625299 PMID:16084531 PMID:17005195

NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326

Atp6v0d1

ATPase H+ transporting V0 subunit D1

multiple interactions

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATP6V0D1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATP6V0D1 mRNA]

PMID:29307831 PMID:31319114

NCBI chr19:37,481,782...37,525,762
Ensembl chr19:37,481,782...37,525,762

Atp6v0d2

ATPase H+ transporting V0 subunit D2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ATP6V0D2 mRNA
[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]

PMID:22129741 PMID:30742845

NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462

Atr

ATR serine/threonine kinase

multiple interactions

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein]

PMID:26451628

NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947

Atxn1

ataxin 1

affects localization
multiple interactions

Acetylcysteine affects the localization of ATXN1 protein mutant form
Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]

PMID:12893416

NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814

Aurkb

aurora kinase B

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of AURKB protein]

PMID:28343997

NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991

B2m

beta-2 microglobulin

decreases response to substance
multiple interactions

Acetylcysteine results in decreased susceptibility to B2M protein modified form
Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species]

PMID:21864514

NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309

B3galt5

Beta-1,3-galactosyltransferase 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GALT5 mRNA

NCBI chr11:36,638,067...36,683,915
Ensembl chr11:36,634,662...36,683,672

B3gnt9

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GNT9 mRNA

NCBI chr19:37,208,061...37,212,400
Ensembl chr19:37,208,825...37,210,412

Bach1

BTB domain and CNC homolog 1

multiple interactions

Acetylcysteine inhibits the reaction [arsenic trioxide affects the localization of BACH1 protein]

PMID:19350554

NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842

Bad

BCL2-associated agonist of cell death

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAD protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BAD protein]
Acetylcysteine results in increased expression of BAD mRNA

PMID:21310227 PMID:22245127 PMID:26332274

NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453

Bag3

BAG cochaperone 3

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA]

NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191

Bak1

BCL2-antagonist/killer 1

multiple interactions

Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAK1]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAK1 mRNA]

PMID:21533816 PMID:21549813 PMID:22085843 PMID:23339468 PMID:28296042

NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260

Barx2

BARX homeobox 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BARX2 mRNA

NCBI chr 8:32,950,878...33,018,245
Ensembl chr 8:32,950,875...33,017,854

Bax

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
decreases expression

Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]
Acetylcysteine affects the reaction [lead acetate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased expression of BAX mRNA]
Acetylcysteine results in increased expression of BAX mRNA
Acetylcysteine results in decreased expression of BAX protein
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased cleavage of BAX protein]; Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of BAX protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; Acetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester) affects the expression of BAX protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tomentosin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased expression of BAX protein]
Acetylcysteine results in increased expression of BAX protein

PMID:11166918 PMID:11341981 PMID:15496615 PMID:15735709 PMID:16169029 PMID:17237268 PMID:17542780 PMID:17574045 PMID:18034189 PMID:18412143 PMID:18547707 PMID:19376147 PMID:19954742 PMID:20674558 PMID:20981856 PMID:21310227 PMID:21533816 PMID:21549813 PMID:21616140 PMID:22085843 PMID:22245127 PMID:22704995 PMID:23711929 PMID:24036456 PMID:25034532 PMID:25845326 PMID:26332274 PMID:26512966 PMID:26772155 PMID:26797587 PMID:26804764 PMID:27189055 PMID:27816613 PMID:28804952 PMID:29087013 PMID:29248572 PMID:29945211 PMID:30104959 PMID:30769050 PMID:30797898 PMID:30917517 PMID:31173782 PMID:31313457 PMID:32540572

NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207

Bbc3

Bcl-2 binding component 3

multiple interactions

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]
Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]

PMID:24291486 PMID:32540572

NCBI chr 1:78,261,491...78,267,802

Bcas1

brain enriched myelin associated protein 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCAS1 mRNA

NCBI chr 3:167,957,994...168,033,462
Ensembl chr 3:167,957,994...168,033,457

Bche

butyrylcholinesterase

multiple interactions

Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of BCHE protein]

PMID:27087133

NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395

Bcl2

BCL2, apoptosis regulator

decreases expression
multiple interactions
decreases response to substance

Acetylcysteine results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [nickel acetate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Propofol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester) affects the expression of BCL2 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in decreased expression of BCL2 protein]
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]]
BCL2 results in decreased susceptibility to Acetylcysteine

PMID:11341981 PMID:17041759 PMID:17395010 PMID:17542780 PMID:18077580 PMID:18412143 PMID:19082730 PMID:19679660 PMID:19954742 PMID:20674558 PMID:21310227 PMID:21549813 PMID:21600978 PMID:21616140 PMID:22085843 PMID:22245127 PMID:22578287 PMID:22704995 PMID:22976841 PMID:23711929 PMID:24036456 PMID:24909818 PMID:25034532 PMID:25845326 PMID:26079211 PMID:26772155 PMID:27816613 PMID:28804952 PMID:28918123 PMID:29248572 PMID:30104959 PMID:30769050 PMID:30796935 PMID:30797898 PMID:30917517 PMID:31157476 PMID:31173782 PMID:31563593

NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374

Bcl2l1

Bcl2-like 1

multiple interactions

Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [Carboplatin results in decreased expression of BCL2L1 protein]
Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [nickel acetate results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of BCL2L1 protein]

PMID:18281123 PMID:18483861 PMID:20594983 PMID:21310227 PMID:22085843 PMID:22245127 PMID:23711929 PMID:30917517 PMID:31313457

NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810

Bcl2l11

BCL2 like 11

multiple interactions

Acetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased expression of BCL2L11 protein]

PMID:15173094

NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192

Bcl6

BCL6, transcription repressor

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA

NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075

Bdkrb1

bradykinin receptor B1

multiple interactions

Acetylcysteine inhibits the reaction [Capsaicin results in increased expression of BDKRB1 mRNA]

PMID:22264228

NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574

Bdnf

brain-derived neurotrophic factor

multiple interactions

Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of BDNF protein]

PMID:16553631 PMID:26138014

NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210

Becn1

beclin 1

multiple interactions

Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [pyrovalerone analog results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Vorinostat results in increased expression of BECN1 protein]
Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of BECN1 protein]
Acetylcysteine inhibits the reaction [[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein]

PMID:20543569 PMID:21216964 PMID:24614525 PMID:26588882 PMID:26804764 PMID:27106530 PMID:28025121 PMID:28063998 PMID:28578026 PMID:28600122 PMID:29923297 PMID:31563593 PMID:32687844

NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297

Bid

BH3 interacting domain death agonist

multiple interactions

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [sanguinarine results in increased cleavage of BID protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of BID protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased cleavage of BID protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BID protein]
Acetylcysteine inhibits the reaction [7-ketocholesterol results in decreased expression of BID protein]

PMID:16169029 PMID:17574045 PMID:21310227 PMID:23660334 PMID:23711929 PMID:25034532 PMID:25845326 PMID:30408460

NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203

Bik

BCL2-interacting killer

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BIK protein]

PMID:31313457

NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447

Birc2

baculoviral IAP repeat-containing 2

multiple interactions

Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein]

PMID:19679660

NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142

Birc3

baculoviral IAP repeat-containing 3

multiple interactions

Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC3 protein]

PMID:19679660

NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598

Birc5

baculoviral IAP repeat-containing 5

multiple interactions

Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [YM 155 results in decreased expression of BIRC5 protein]

PMID:21741372 PMID:23711929 PMID:25034532 PMID:31837377

NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413

Bmp5

bone morphogenetic protein 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BMP5 mRNA

NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273

Bmp7

bone morphogenetic protein 7

multiple interactions

[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of BMP7 mRNA

NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399

Bnip3

BCL2 interacting protein 3

multiple interactions

Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]

PMID:19442826

NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282

Bpgm

bisphosphoglycerate mutase

decreases expression

Acetylcysteine results in decreased expression of BPGM mRNA

NCBI chr 4:61,912,210...61,940,697
Ensembl chr 4:61,912,210...61,940,696

Btg1

BTG anti-proliferation factor 1

decreases expression

Acetylcysteine results in decreased expression of BTG1 mRNA

NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088

complement C3

multiple interactions

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of C3 protein modified form]

PMID:20946910

NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167

Cacna1g

calcium voltage-gated channel subunit alpha1 G

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CACNA1G mRNA

NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848

Capn1

calpain 1

multiple interactions

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN1 protein]

PMID:25451595

NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322

Capn2

calpain 2

multiple interactions

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN2 protein]

PMID:25451595

NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811

Casp1

caspase 1

multiple interactions

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein]
Acetylcysteine inhibits the reaction [arsenic trioxide inhibits the reaction [anthrax toxin results in increased cleavage of CASP1 protein]]; Acetylcysteine inhibits the reaction [Glucose results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]

PMID:23940760 PMID:24337744 PMID:24885895 PMID:25929180 PMID:26079697 PMID:26086368 PMID:26435000 PMID:26809137 PMID:26901245 PMID:27783111 PMID:28004443 PMID:28814068 PMID:30205151 PMID:30878009 PMID:30977640

NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631

Casp12

caspase 12

multiple interactions

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased cleavage of CASP12 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP12 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]

PMID:18077580 PMID:21145380 PMID:21616140 PMID:25451595 PMID:28296042 PMID:31330229

NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160

Casp14

caspase 14

multiple interactions

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CASP14 protein]

PMID:16137721

NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130

Casp2

caspase 2

multiple interactions

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein]
Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP2 protein]
Acetylcysteine inhibits the reaction [[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased cleavage of CASP2 protein]

PMID:15158148 PMID:17041759 PMID:21216964 PMID:30408460

NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239

Casp3

caspase 3

increases cleavage
increases activity
multiple interactions
increases expression
decreases activity

Acetylcysteine results in increased cleavage of CASP3 protein
Acetylcysteine results in increased activity of CASP3 protein
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [arsenite results in decreased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP3]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [JP8 aviation fuel results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [menadione epoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]
[Glucose deficiency co-treated with Acetylcysteine] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [8-bromo-7-methoxychrysin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[[Thimerosal results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP3 protein] which results in increased cleavage of PTK2 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Naphthalimides co-treated with Spermidine] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Pentachlorophenol co-treated with copper-1,10-phenanthroline] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[sulforafan co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Vitamin K 2 co-treated with Arsenic Trioxide] results in increased expression of CASP3]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cannabidiol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [dimethoxycurcumin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Eosine I Bluish results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [ganoderic acid analog results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T analog results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [manumycin results in increased activity of CASP3]; Acetylcysteine inhibits the reaction [menadione epoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [NCX 4040 results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [platycodin D results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Prodigiosin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [pyrovalerone analog results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Soot analog results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [sulforafan promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased cleavage of CASP3 protein]; Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of CASP3 protein]; Acetylcysteine promotes the reaction [sinularin results in increased cleavage of CASP3 protein]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased cleavage of CASP3 protein]; Oxygen deficiency affects the reaction [Acetylcysteine results in increased activity of CASP3 protein]
Acetylcysteine results in increased expression of CASP3 protein modified form
Acetylcysteine results in decreased activity of CASP3 protein
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Acetylcysteine affects the reaction [nonylphenol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [maduramicin results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [nitrofen results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Acetylcysteine results in increased expression of CASP3 protein modified form]

PMID:11969376 PMID:12168106 PMID:12750841 PMID:12754411 PMID:14660655 PMID:15050407 PMID:15158148 PMID:15375156 PMID:15496615 PMID:15545282 PMID:15582350 PMID:15683462 PMID:15816534 PMID:16014620 PMID:16169029 PMID:16282376 PMID:17041759 PMID:17136323 PMID:17309078 PMID:17332930 PMID:17468103 PMID:17542780 PMID:17574045 PMID:17888894 PMID:18077580 PMID:18281123 PMID:18483861 PMID:18547707 PMID:18703135 PMID:18791325 PMID:18804340 PMID:19014919 PMID:19082730 PMID:19376147 PMID:19409983 PMID:19477266 PMID:19523979 PMID:19536524 PMID:19722195 PMID:19771260 PMID:19837105 PMID:19840221 PMID:20100472 PMID:20114059 PMID:20362650 PMID:20594983 PMID:20632440 PMID:20674558 PMID:20883752 PMID:20946910 PMID:20981856 PMID:21145380 PMID:21166495 PMID:21221209 PMID:21242791 PMID:21300145 PMID:21310227 PMID:21349322 PMID:21418039 PMID:21453688 PMID:21533816 PMID:21549813 PMID:21565247 PMID:21600974 PMID:21616140 PMID:21741372 PMID:21804221 PMID:21843585 PMID:21998720 PMID:22002103 PMID:22085843 PMID:22260869 PMID:22440610 PMID:22578287 PMID:22710416 PMID:22714038 PMID:22824136 PMID:22909951 PMID:22922937 PMID:23405080 PMID:23677851 PMID:23711929 PMID:23836369 PMID:23867903 PMID:24036456 PMID:24157283 PMID:24273890 PMID:24291486 PMID:24299490 PMID:24412703 PMID:24614525 PMID:24634002 PMID:24908156 PMID:24998639 PMID:25034532 PMID:25341683 PMID:25568320 PMID:25845326 PMID:25891866 PMID:25940438 PMID:25947082 PMID:26079211 PMID:26124276 PMID:26282491 PMID:26549478 PMID:26588882 PMID:26630137 PMID:26772155 PMID:26804764 PMID:27106530 PMID:27417252 PMID:27484784 PMID:27539140 PMID:28025121 PMID:28063998 PMID:28219700 PMID:28237877 PMID:28296042 PMID:28548367 PMID:28578026 PMID:28778520 PMID:28804952 PMID:28918123 PMID:29087013 PMID:29108775 PMID:29111403 PMID:29248572 PMID:29432840 PMID:29454061 PMID:29484840 PMID:29774349 PMID:29944906 PMID:29945211 PMID:30037311 PMID:30236763 PMID:30240709 PMID:30259999 PMID:30590774 PMID:30633982 PMID:30769050 PMID:30796935 PMID:30871965 PMID:30917517 PMID:31077745 PMID:31157476 PMID:31173782 PMID:31229567 PMID:31313457 PMID:31330229 PMID:31381934 PMID:31408635 PMID:31433961 PMID:32540572 PMID:32708634

NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204

Casp4

caspase 4

multiple interactions

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CASP4 mRNA]
Acetylcysteine inhibits the reaction [[sulforafan co-treated with arsenic trioxide] results in increased cleavage of CASP4 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]
Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP4 mRNA]

PMID:16137721 PMID:19477266 PMID:22922937 PMID:25341683

NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652

Casp6

caspase 6

multiple interactions

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein]
Acetylcysteine inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]

PMID:15158148 PMID:19954742

NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967

Casp7

caspase 7

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of CASP7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of CASP7 protein modified form]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP7 mRNA]
Acetylcysteine results in decreased expression of CASP7 protein modified form
Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP7 protein modified form]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP7 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of CASP7 protein]
Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP7 protein]

PMID:17136323 PMID:19771260 PMID:20594983 PMID:21145380 PMID:21549813 PMID:21843585 PMID:22085843 PMID:22260869 PMID:22909951 PMID:23405080 PMID:24157283 PMID:24998639 PMID:25824409 PMID:27106530 PMID:27539140 PMID:28087840 PMID:28161410 PMID:29800641 PMID:30408460 PMID:30917517 PMID:31313457 PMID:31330229 PMID:31433961

NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774

Casp8

caspase 8

multiple interactions

Acetylcysteine inhibits the reaction [cannabidiol hydroxyquinone results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein]
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]; [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP8 protein]
Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [sinularin results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP8 protein]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased activity of and results in increased cleavage of CASP8 protein]

PMID:16169029 PMID:17574045 PMID:18791325 PMID:19014919 PMID:19477266 PMID:20184945 PMID:20576514 PMID:20674558 PMID:20883752 PMID:20946910 PMID:21310227 PMID:22578287 PMID:23711929 PMID:23867903 PMID:24614525 PMID:25034532 PMID:25845326 PMID:27313093 PMID:27484784 PMID:28087840 PMID:28219700 PMID:28548367 PMID:28918123 PMID:29432840 PMID:30917517

NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106

Casp9

caspase 9

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [monomethylarsonous acid results in decreased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP9 protein]
Acetylcysteine results in increased expression of CASP9 protein modified form
Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [CASP9 protein binds to CYCS protein]]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP9]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]
[Glucose deficiency co-treated with Acetylcysteine] results in increased activity of CASP9 protein; Acetylcysteine affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [ganoderic acid analog results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T analog results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [oenothein B results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [sinularin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Soot analog results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP9 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of CASP9 protein]

PMID:15158148 PMID:15496615 PMID:16169029 PMID:17309078 PMID:17574045 PMID:18336854 PMID:18483861 PMID:18594523 PMID:18629305 PMID:18791325 PMID:19082730 PMID:19477266 PMID:19771260 PMID:20576514 PMID:20848084 PMID:21145380 PMID:21166495 PMID:21310227 PMID:21418039 PMID:21549813 PMID:21616140 PMID:22002103 PMID:22085843 PMID:22578287 PMID:22714038 PMID:23405080 PMID:23711929 PMID:23867903 PMID:24157283 PMID:24614525 PMID:24634002 PMID:25845326 PMID:25940438 PMID:26282491 PMID:27313093 PMID:27539140 PMID:28296042 PMID:28548367 PMID:28804952 PMID:28918123 PMID:29108775 PMID:29432840 PMID:29945211 PMID:30240709 PMID:30408460 PMID:30452899 PMID:30769050 PMID:30917517 PMID:31313457 PMID:31330229 PMID:31433961

NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778

Cat

catalase

multiple interactions
decreases activity
increases expression

Acetylcysteine inhibits the reaction [Carmustine results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dimethylnitrosamine results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [Zinc results in decreased expression of CAT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Particulate Matter results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [ceric oxide results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos affects the activity of CAT protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Propofol results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Smoke analog results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of CAT mRNA]; CAT protein inhibits the reaction [Acetylcysteine results in increased abundance of Hydrogen Peroxide]
Acetylcysteine results in decreased activity of CAT protein
Acetylcysteine results in increased expression of CAT protein
Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased activity of CAT protein]

PMID:7491977 PMID:16169029 PMID:19840221 PMID:19853593 PMID:20332008 PMID:21114986 PMID:21131394 PMID:22416658 PMID:22427991 PMID:23416263 PMID:24299490 PMID:24485406 PMID:24577230 PMID:24810974 PMID:26079211 PMID:26257840 PMID:26769589 PMID:27235710 PMID:27246665 PMID:28012895 PMID:28013216 PMID:28108387 PMID:28804952 PMID:29143438 PMID:30037311 PMID:30423402 PMID:30769050 PMID:30951941 PMID:30998386 PMID:31157476

NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058

Cav1

caveolin 1

decreases expression
multiple interactions

Acetylcysteine results in decreased expression of CAV1
Acetylcysteine inhibits the reaction [rosiglitazone results in increased expression of CAV1]; Acetylcysteine results in increased ubiquitination of and results in increased degradation of CAV1 protein; Hydrogen Peroxide inhibits the reaction [Acetylcysteine results in increased ubiquitination of and results in increased degradation of CAV1 protein]

PMID:18507034 PMID:21148404

NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200

Cbs

cystathionine beta synthase

multiple interactions

Acetylcysteine inhibits the reaction [Rotenone results in decreased expression of CBS protein]

PMID:25086357

NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751

Ccl11

C-C motif chemokine ligand 11

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CCL11 mRNA
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CCL11 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 protein]

PMID:12576300 PMID:22129741 PMID:26138014

NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575

Ccl17

C-C motif chemokine ligand 17

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL17 protein]

NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671

Ccl2

C-C motif chemokine ligand 2

multiple interactions

Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
Acetylcysteine inhibits the reaction [Palmitates results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]]
Acetylcysteine affects the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]]

PMID:10541287 PMID:11124598 PMID:15139008 PMID:17529908 PMID:18303122 PMID:19158351 PMID:22700867 PMID:26332274 PMID:26683377 PMID:28555929

NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870

Ccl20

C-C motif chemokine ligand 20

decreases expression

Acetylcysteine results in decreased expression of CCL20 mRNA

PMID:22385246

NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001

Ccl22

C-C motif chemokine ligand 22

multiple interactions

Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CCL22 mRNA]

PMID:19350554

NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145

Ccl24

C-C motif chemokine ligand 24

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CCL24 protein]

NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625

Ccl3

C-C motif chemokine ligand 3

multiple interactions
decreases secretion

[Acetylcysteine co-treated with Particulate Matter] results in increased secretion of CCL3 protein; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CCL3 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]; Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]]; Acetylcysteine promotes the reaction [Polymyxin B results in decreased secretion of CCL3 protein]; MYD88 protein affects the reaction [[Acetylcysteine co-treated with Particulate Matter] results in increased secretion of CCL3 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine results in decreased secretion of CCL3 protein]

PMID:21765237 PMID:28555929

NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066

Ccl5

C-C motif chemokine ligand 5

multiple interactions

Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL5 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]

PMID:10495789 PMID:11167962 PMID:26138014

NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315

Ccn1

cellular communication network factor 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]; Cycloheximide inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]
Acetylcysteine results in increased expression of CCN1 mRNA; Acetylcysteine results in increased expression of CCN1 protein

PMID:21055460

NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312

Ccn2

cellular communication network factor 2

multiple interactions

Acetylcysteine inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

PMID:17270171

NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773

Ccna1

cyclin A1

multiple interactions

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CCNA1 protein]

PMID:20654705

NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912

Ccna2

cyclin A2

multiple interactions

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCNA2 protein]
Acetylcysteine inhibits the reaction [alpha-terthienylmethanol results in increased expression of CCNA2 protein]

PMID:24909818 PMID:28506552

NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214

Ccnb1

cyclin B1

multiple interactions

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CCNB1 protein]; Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CCNB1 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CCNB1 protein]; Acetylcysteine inhibits the reaction [sinularin results in decreased phosphorylation of CCNB1 protein]

PMID:24909818 PMID:25633853 PMID:28548367 PMID:29128613

NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221

Ccnd1

cyclin D1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [[Vorinostat co-treated with Butyrates] results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of CCND1 protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 protein]
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in decreased expression of CCND1 protein]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of CCND1 protein]

PMID:15173093 PMID:15897899 PMID:17602960 PMID:18563748 PMID:19409983 PMID:21600978 PMID:23948867 PMID:24355586 PMID:24909818 PMID:24968063 PMID:26332274 PMID:28321046 PMID:31433961

NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325

Ccnd2

cyclin D2

multiple interactions

Acetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CCND2 mRNA]
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]

PMID:19615393 PMID:26332274

NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207

Ccne1

cyclin E1

multiple interactions

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCNE1 protein]

PMID:15945272 PMID:24909818

NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980

Ccne2

cyclin E2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406

Cd14

CD14 molecule

multiple interactions

Acetylcysteine inhibits the reaction [Iron deficiency results in increased expression of CD14 protein]

PMID:20368581

NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153

Cd36

CD36 molecule

multiple interactions

Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CD36 mRNA]
Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CD36 mRNA promotes the reaction [Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]

PMID:22824115 PMID:26187465

NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749

Cd40lg

CD40 ligand

multiple interactions

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA]
Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]

PMID:19477266 PMID:27634759

NCBI chr X:159,703,703...159,714,886
Ensembl chr X:159,703,578...159,716,562

Cd86

CD86 molecule

multiple interactions

Acetylcysteine affects the reaction [Dinitrochlorobenzene affects the expression of CD86 protein]; Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]

PMID:19033392 PMID:19641517 PMID:20417223 PMID:20457211 PMID:30842373

NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795

Cdc25c

cell division cycle 25C

multiple interactions

Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CDC25C protein modified form]

PMID:25633853

NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224

Cdh1

cadherin 1

multiple interactions

Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]; Acetylcysteine inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased methylation of CDH1 promoter]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [SHC1 protein results in decreased expression of CDH1 protein]

PMID:18791180 PMID:22648416 PMID:24820114 PMID:28284859 PMID:32659284 PMID:32687844

NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395

Cdh11

cadherin 11

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDH11 mRNA

NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245

Cdh13

cadherin 13

decreases expression

Acetylcysteine results in decreased expression of CDH13 mRNA

NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103

Cdh2

cadherin 2

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]
Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of CDH2 mRNA]

PMID:23876460 PMID:24820114 PMID:28284859

NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684

Cdk1

cyclin-dependent kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CDK1 protein]
Acetylcysteine inhibits the reaction [sinularin results in decreased phosphorylation of CDK1 protein]

PMID:25633853 PMID:28548367

NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549

Cdk4

cyclin-dependent kinase 4

multiple interactions

Acetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CDK4 mRNA]

PMID:19615393

NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression
increases expression

Acetylcysteine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of CDKN1A]; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1A enhancer]
Acetylcysteine results in decreased expression of CDKN1A mRNA
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1A protein]

PMID:8943236 PMID:9343371 PMID:12208374 PMID:15496615 PMID:15978937 PMID:17602960 PMID:18022818 PMID:19409983 PMID:21462292 PMID:21565247 PMID:22129741 PMID:22183962 PMID:22927544 PMID:24792323 PMID:26332274 PMID:26658076 PMID:30555576 PMID:32473187

NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864

Cdkn1b

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

Acetylcysteine results in increased expression of CDKN1B protein
Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]; Acetylcysteine inhibits the reaction [tomentosin results in increased expression of CDKN1B protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1B enhancer]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1B protein]

PMID:17602960 PMID:18022818 PMID:30917517

NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964

Cdkn2a

cyclin-dependent kinase inhibitor 2A

multiple interactions

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [DNMT1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [EZH2 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [KDM2A protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [TET1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN2A protein]
Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN2A protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]

PMID:31551408 PMID:32473187

NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175

Cebpa

CCAAT/enhancer binding protein alpha

multiple interactions

Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]

PMID:27117918

NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164

Cebpb

CCAAT/enhancer binding protein beta

multiple interactions

Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]

PMID:21220312

NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910

Cebpe

CCAAT/enhancer binding protein epsilon

multiple interactions

Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]]

PMID:29945211

NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138

Cflar

CASP8 and FADD-like apoptosis regulator

multiple interactions

Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]

PMID:25034532 PMID:25619640

NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251

Cftr

CF transmembrane conductance regulator

multiple interactions

Acetylcysteine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; Acetylcysteine inhibits the reaction [Ozone results in decreased expression of CFTR protein]

PMID:19061877

NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676

Chat

choline O-acetyltransferase

increases expression
multiple interactions

Acetylcysteine results in increased expression of CHAT protein
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein; Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]

PMID:25891525

NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131

Chek1

checkpoint kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]
Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form]

PMID:15489221 PMID:25633853

NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882

Chek2

checkpoint kinase 2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of CHEK2 protein modified form]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased phosphorylation of CHEK2 protein]; Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein]
Acetylcysteine results in increased expression of CHEK2 protein

PMID:15489221 PMID:23274516 PMID:24792323 PMID:24933654 PMID:31715134

NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624

Chka

choline kinase alpha

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CHKA mRNA

NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220

Chrm2

cholinergic receptor, muscarinic 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CHRM2 mRNA
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM2 mRNA]

PMID:22129741 PMID:29253600

NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090

Chrm3

cholinergic receptor, muscarinic 3

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM3 mRNA]

PMID:29253600

NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169

Chrm4

cholinergic receptor, muscarinic 4

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM4 mRNA]

PMID:29253600

NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006

Chuk

component of inhibitor of nuclear factor kappa B kinase complex

decreases activity

Acetylcysteine results in decreased activity of CHUK protein

PMID:17395010

NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169

Cish

cytokine inducible SH2-containing protein

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CISH mRNA

NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723

Ckb

creatine kinase B

multiple interactions

[Deferoxamine co-treated with Acetylcysteine] inhibits the reaction [Acetaminophen results in decreased activity of CKB protein]; [Deferoxamine co-treated with Acetylcysteine] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CKB protein]

PMID:19688255

NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837

Ckm

creatine kinase, M-type

multiple interactions
decreases secretion

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CKM mRNA]
Acetylcysteine results in decreased secretion of CKM protein

PMID:9689591 PMID:21912612

NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841

Cldn1

claudin 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CLDN1 mRNA
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CLDN1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of CLDN1 protein]

PMID:22129741 PMID:28115242 PMID:29235125

NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416

Cldn4

claudin 4

multiple interactions

Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]

PMID:23816505

NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005

Cldn5

claudin 5

multiple interactions

Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CLDN5 protein]

PMID:28115242

NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718

Clec9a

C-type lectin domain containing 9A

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CLEC9A mRNA

NCBI chr 4:163,173,593...163,189,532
Ensembl chr 4:163,174,487...163,189,530

Clk1

CDC-like kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of CLK1 mRNA]

NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995

Cma1

chymase 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CMA1 mRNA

NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819

Cntf

ciliary neurotrophic factor

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CNTF protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]

PMID:16896058 PMID:26138014

NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032

Col18a1

collagen type XVIII alpha 1 chain

multiple interactions

Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]

PMID:13679210

NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858

Col1a1

collagen type I alpha 1 chain

decreases expression
multiple interactions

Acetylcysteine results in decreased expression of COL1A1 mRNA
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of COL1A1 protein]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 protein]
Acetylcysteine results in decreased expression of COL1A1 mRNA; Acetylcysteine results in decreased expression of COL1A1 protein

PMID:11710721 PMID:17602960 PMID:32659284

NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789

Col1a2

collagen type I alpha 2 chain

decreases expression

Acetylcysteine results in decreased expression of COL1A2 mRNA

PMID:11710721

NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151

Col4a1

collagen type IV alpha 1 chain

decreases expression

Acetylcysteine results in decreased expression of COL4A1 mRNA

NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153

Colq

collagen like tail subunit of asymmetric acetylcholinesterase

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of COLQ mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of COLQ mRNA]

NCBI chr16:7,626,380...7,681,621
Ensembl chr16:7,627,603...7,681,576

Cpe

carboxypeptidase E

decreases expression

Acetylcysteine results in decreased expression of CPE mRNA

NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813

Cplx1

complexin 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CPLX1 mRNA

NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598

Cpt1a

carnitine palmitoyltransferase 1A

multiple interactions

[Acetylcysteine co-treated with Dietary Fats] results in increased expression of CPT1A mRNA

NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678

Cpt1b

carnitine palmitoyltransferase 1B

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CPT1B mRNA

NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347

Cradd

CASP2 and RIPK1 domain containing adaptor with death domain

decreases expression

Acetylcysteine results in decreased expression of CRADD mRNA

NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588

Crat

carnitine O-acetyltransferase

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CRAT mRNA

NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362

Creb1

cAMP responsive element binding protein 1

multiple interactions

Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]
Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of CREB1 protein]

PMID:18375950 PMID:32433928

NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435

Crem

cAMP responsive element modulator

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CREM mRNA]

PMID:25381014

NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888

Cryab

crystallin, alpha B

multiple interactions

Acetylcysteine inhibits the reaction [arsenite results in increased expression of CRYAB protein]

NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545

Cryga

crystallin, gamma A

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CRYGA mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CRYGA mRNA]

NCBI chr 9:71,828,308...71,855,900
Ensembl chr 9:71,835,883...71,852,113
Ensembl chr 9:71,835,883...71,852,113

citrate synthase

multiple interactions

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of CS mRNA]
Acetylcysteine promotes the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

PMID:21775390 PMID:27385396

NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963

Csf1r

colony stimulating factor 1 receptor

multiple interactions

[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]

PMID:30742845

NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300

Csf2

colony stimulating factor 2

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CSF2 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein]

PMID:10645887 PMID:19460412 PMID:26138014 PMID:29753051

NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070

Csf3r

colony stimulating factor 3 receptor

multiple interactions

Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of CSF3R mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of CSF3R mRNA]]

PMID:29945211

NCBI chr 5:144,031,353...144,051,966
Ensembl chr 5:144,031,402...144,051,600

Ctnnb1

catenin beta 1

multiple interactions

Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased phosphorylation of CTNNB1 protein]
Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CTNNB1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; Acetylcysteine inhibits the reaction [NCX 4040 results in increased cleavage of CTNNB1 protein]; Acetylcysteine inhibits the reaction [quinocetone results in decreased expression of CTNNB1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]

PMID:16282376 PMID:19436114 PMID:24961358 PMID:24968063 PMID:28321046 PMID:28343033

NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372

Ctrc

chymotrypsin C

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CTRC mRNA

NCBI chr 5:160,394,677...160,403,373
Ensembl chr 5:160,394,580...160,405,050

Ctrl

chymotrypsin-like

multiple interactions

Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein]

PMID:31276663

NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714

Ctsb

cathepsin B

multiple interactions

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CTSB mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of CTSB mRNA]

PMID:29307831 PMID:31319114

NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612

Ctsk

cathepsin K

multiple interactions

[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]

PMID:30742845

NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446

Cux2

cut-like homeobox 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CUX2 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA]

NCBI chr12:40,016,774...40,221,067
Ensembl chr12:40,018,937...40,219,291

Cxcl1

C-X-C motif chemokine ligand 1

decreases expression
multiple interactions

Acetylcysteine results in decreased expression of CXCL1 protein
Acetylcysteine analog inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of CXCL1 protein]; Acetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]

PMID:17395010 PMID:18257742

NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457

Cxcl12

C-X-C motif chemokine ligand 12

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CXCL12 protein]

NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891

Cxcl2

C-X-C motif chemokine ligand 2

multiple interactions

Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of CXCL2 mRNA]; Acetylcysteine inhibits the reaction [Vanadates results in increased expression of CXCL2 mRNA]
Acetylcysteine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CXCL2 protein]

PMID:10718115 PMID:16919916 PMID:19350554 PMID:21507677

NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391

Cxcl3

C-X-C motif chemokine ligand 3

decreases expression
multiple interactions

Acetylcysteine results in decreased expression of CXCL1 protein
Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]

PMID:17395010 PMID:24316229 PMID:28555929

NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595

Cxcl6

C-X-C motif chemokine ligand 6

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CXCL6 protein]

NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407

Cyba

cytochrome b-245 alpha chain

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]

PMID:21195169

NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876

Cybb

cytochrome b-245 beta chain

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]

PMID:21195169 PMID:29087013

NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547

Cycs

cytochrome c, somatic

multiple interactions

Acetylcysteine inhibits the reaction [dimethoxycurcumin affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [sodium arsenite affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein affects the localization of CYCS protein]
Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [CASP9 protein binds to CYCS protein]]; Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds affects the localization of CYCS protein]

PMID:18483861 PMID:19536524 PMID:19954742 PMID:21145380 PMID:21221209 PMID:21549813 PMID:22085843 PMID:23711929 PMID:24634002 PMID:28296042 PMID:29248572

NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326

Cyct

cytochrome c, testis

multiple interactions

Acetylcysteine inhibits the reaction [Estradiol results in increased expression of CYCT protein]

PMID:15545282

NCBI chr 3:63,204,779...63,211,847
Ensembl chr 3:62,818,502...63,211,845

Cyp11a1

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]

PMID:26769589 PMID:29567110

NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893

Cyp11b2

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions

Acetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B1 mRNA]; Acetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B1 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]

PMID:25617244

NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167

Cyp11b3

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

Acetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]; Acetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B2 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]

PMID:25617244

NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167

Cyp17a1

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]

PMID:29567110

NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] which results in decreased expression of NQO1 mRNA; Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Acetylcysteine inhibits the reaction [1-(4-chlorophenyl)-benzo-2,5-quinone results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of CYP1A1 mRNA; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
[Acetylcysteine co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Acetylcysteine affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased activity of CYP1A1 protein]; Acetylcysteine inhibits the reaction [beta-Naphthoflavone results in decreased activity of CYP1A1 protein]; Acetylcysteine inhibits the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Acetylcysteine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]

PMID:15044633 PMID:15621696 PMID:16274885 PMID:19033395 PMID:20801209 PMID:21094198 PMID:21703343 PMID:22129741 PMID:25668756 PMID:26535918 PMID:27041069 PMID:29753051 PMID:29975444 PMID:30639957 PMID:30793600

NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147

Cyp1a2

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP1A2 mRNA]
[CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite

PMID:21424224 PMID:22129741 PMID:23159886 PMID:27989148

NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYP1B1 mRNA]

PMID:21703343 PMID:22129741

NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722

Cyp26c1

cytochrome P450, family 26, subfamily C, polypeptide 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CYP26C1 mRNA

NCBI chr 1:256,369,410...256,380,649
Ensembl chr 1:256,370,850...256,378,335

Cyp2a3

cytochrome P450, family 2, subfamily a, polypeptide 3

multiple interactions

Acetylcysteine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2A5 protein]

PMID:22552773

NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484

Cyp2b1

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Acetylcysteine promotes the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]

PMID:11353799 PMID:14722249

NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783

Cyp2b31

cytochrome P450, family 2, subfamily b, polypeptide 31

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CYP2B31 mRNA

Cyp2c6v1

cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1

multiple interactions

[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite

PMID:27989148

NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007

Cyp2e1

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]; Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]
Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]

PMID:21424224 PMID:23159886 PMID:26332274 PMID:30423402

NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542

Cyp3a62

cytochrome P450, family 3, subfamily a, polypeptide 62

multiple interactions

[CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite; Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]

PMID:25451576 PMID:27989148

NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397

Cyp4a1

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CYP4A1 mRNA; Acetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A1 mRNA]

PMID:19647067 PMID:22129741

NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154

Dapk1

death associated protein kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]

PMID:19477266

NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778

Ddhd1

DDHD domain containing 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DDHD1 mRNA

NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191

Ddit3

DNA-damage inducible transcript 3

increases expression
decreases expression
multiple interactions

Acetylcysteine results in increased expression of DDIT3 mRNA; Acetylcysteine results in increased expression of DDIT3 protein
Acetylcysteine results in decreased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein]
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]; Acetylcysteine inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of DDIT3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Benomyl results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [discretamine results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Ethylmercury Compounds results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Quercetin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [rhododendrol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Win 55212-2 results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]
Acetylcysteine inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]

PMID:16084531 PMID:17171638 PMID:18077580 PMID:18384088 PMID:19722195 PMID:20493918 PMID:21145380 PMID:21198628 PMID:21266191 PMID:21533816 PMID:21616140 PMID:23339468 PMID:24157283 PMID:24291486 PMID:24394546 PMID:24612139 PMID:24802810 PMID:24930757 PMID:25341683 PMID:25451595 PMID:25568320 PMID:25817893 PMID:25950987 PMID:26203587 PMID:26772155 PMID:26867644 PMID:27484784 PMID:27511942 PMID:27634458 PMID:27658547 PMID:27784618 PMID:27816613 PMID:28296042 PMID:28754437 PMID:29111403 PMID:30502353 PMID:30508555 PMID:31276663 PMID:31330229 PMID:32578922 PMID:32590070

NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084

Ddit4

DNA-damage-inducible transcript 4

multiple interactions

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]

PMID:21266191

NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382

Defb18

defensin beta 18

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DEFB18 mRNA

NCBI chr 9:24,466,981...24,467,892
Ensembl chr 9:24,466,981...24,467,892

Defb4

defensin beta 4

decreases expression

Acetylcysteine results in decreased expression of DEFB4A mRNA

PMID:22385246

NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789

Defb49

defensin beta 49

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DEFB49 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DEFB49 mRNA]

NCBI chr 9:24,445,115...24,451,499
Ensembl chr 9:24,446,264...24,451,435

Dhh

desert hedgehog signaling molecule

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DHH mRNA

NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783

Dio2

iodothyronine deiodinase 2

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]

PMID:18420745

NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723

Dio3

iodothyronine deiodinase 3

multiple interactions

Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Sodium Selenite] promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]

PMID:18420745

NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138

Dkk1

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]

PMID:28321046

NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607

Dlg4

discs large MAGUK scaffold protein 4

multiple interactions

Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein]

PMID:27624276 PMID:28153600

NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599

Dmrt1

doublesex and mab-3 related transcription factor 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DMRT1 mRNA

NCBI chr 1:243,477,403...243,582,629
Ensembl chr 1:243,477,493...243,582,629

Dnah3

dynein, axonemal, heavy chain 3

multiple interactions

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DNAH3 mRNA]

NCBI chr 1:189,708,985...189,865,431

Dnai1

dynein, axonemal, intermediate chain 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DNAI1 mRNA

NCBI chr 5:57,947,796...58,017,985
Ensembl chr 5:57,947,716...58,017,992

Dnajb1

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB1 mRNA]

NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919

Dnajb4

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB4 mRNA]

NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242

Dnajb9

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Acetylcysteine results in increased expression of DNAJB9 mRNA

NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151

Dnm1l

dynamin 1-like

multiple interactions

Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 affects the reaction [DNM1L protein binds to DNM1L protein binds to DNM1L protein binds to DNM1L protein]]
Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate affects the localization of DNM1L protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased expression of and affects the phosphorylation of DNM1L protein]

PMID:20307494 PMID:31408635

NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198

Dnmt1

DNA methyltransferase 1

multiple interactions

[Acetylcysteine co-treated with Hydrogen Peroxide] results in increased expression of DNMT1 mRNA; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased methylation of DNMT1 promoter; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [DNMT1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of DNMT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of DNMT1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of DNMT1 protein]

PMID:29854080 PMID:31150806 PMID:31551408

NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495

Dnmt3b

DNA methyltransferase 3 beta

multiple interactions

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of DNMT3B protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]

PMID:26942697 PMID:31551408

NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786

Dsp

desmoplakin

multiple interactions

Acetylcysteine inhibits the reaction [Dietary Fats results in increased expression of DSP mRNA]

NCBI chr17:27,286,811...27,334,453
Ensembl chr17:27,286,796...27,334,379

Dspp

dentin sialophosphoprotein

increases expression

Acetylcysteine results in increased expression of DSPP mRNA

PMID:20951298

NCBI chr14:6,926,972...6,933,079
Ensembl chr14:6,926,976...6,933,070

Dusp1

dual specificity phosphatase 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DUSP1 protein]

PMID:18573614

NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418

Dusp4

dual specificity phosphatase 4

increases expression

Acetylcysteine results in increased expression of DUSP4 mRNA

NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169

Dut

deoxyuridine triphosphatase

multiple interactions

Acetylcysteine inhibits the reaction [beta-hydroxyisovalerylshikonin results in decreased phosphorylation of and results in decreased activity of DUT protein]

PMID:18078828

NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446

E2f1

E2F transcription factor 1

multiple interactions

Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of E2F1 protein]

PMID:16497787

NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721

Edn1

endothelin 1

multiple interactions

Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
Acetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]

PMID:14623829 PMID:16261333 PMID:21765237

NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324

Efcab3

EF-hand calcium binding domain 3

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EFCAB3 mRNA

NCBI chr10:93,304,559...93,332,849
Ensembl chr10:93,305,969...93,332,702

Efna1

ephrin A1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EFNA1 mRNA

NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222

Efnb2

ephrin B2

decreases expression

Acetylcysteine results in decreased expression of EFNB2 mRNA

NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049

Egf

epidermal growth factor

multiple interactions

Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of EGF protein]; Acetylcysteine inhibits the reaction [cyadox results in increased expression of EGF]; Acetylcysteine inhibits the reaction [EGF protein results in increased secretion of VEGFA mRNA]; Acetylcysteine inhibits the reaction [EGF protein results in increased secretion of VEGFA protein]
Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine]; Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of Peroxides]

PMID:11158190 PMID:11214823 PMID:26138014 PMID:30265530 PMID:32092105

NCBI chr 2:68,820,616...68,895,537

Egfr

epidermal growth factor receptor

multiple interactions

Acetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of EGFR mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; Acetylcysteine inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Acetylcysteine inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of EGFR protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Acetylcysteine inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:10640773 PMID:14660655 PMID:15520183 PMID:15849355 PMID:16261333 PMID:17942915 PMID:21220312 PMID:23948867 PMID:26368632 PMID:26514923 PMID:28123000

NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796

Egr1

early growth response 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of EGR1 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of EGR1 mRNA]
Acetylcysteine inhibits the reaction [platycodin D results in increased expression of EGR1 mRNA]

PMID:10625299 PMID:18804340 PMID:19010381

NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429

Egr2

early growth response 2

multiple interactions

Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of EGR2 mRNA]

PMID:19350554

NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025

Ei24

EI24, autophagy associated transmembrane protein

multiple interactions

Acetylcysteine promotes the reaction [Tobacco Smoke Pollution results in increased expression of EI24 mRNA]

PMID:16137721

NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959

Eif2a

eukaryotic translation initiation factor 2A

multiple interactions

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]]
Acetylcysteine inhibits the reaction [Cadmium results in decreased phosphorylation of EIF2A protein]

PMID:21616140 PMID:25451595 PMID:27658547 PMID:29373603

NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520

Eif2ak3

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]
Acetylcysteine results in decreased expression of EIF2AK3 protein modified form
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2AK3 protein]

PMID:19722195 PMID:25341683 PMID:25451595 PMID:27484784 PMID:27784618 PMID:30300626 PMID:31330229

NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694

Eif2s1

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of EIF2S1 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]
Acetylcysteine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of EIF2S1 protein]

PMID:15788408 PMID:16324875 PMID:21911445 PMID:24291486 PMID:25568320 PMID:27484784 PMID:27634458 PMID:27709270 PMID:27816613 PMID:29380555 PMID:30300626 PMID:31330229

NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041

Eif4ebp1

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]
Acetylcysteine inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]

PMID:21195169 PMID:24299490 PMID:26804764 PMID:30661989

NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248

Emilin2

elastin microfibril interfacer 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EMILIN2 mRNA

NCBI chr 9:119,594,049...119,653,675
Ensembl chr 9:119,594,629...119,653,255

Endog

endonuclease G

multiple interactions

[Glucose deficiency co-treated with Acetylcysteine] affects the localization of ENDOG protein; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]

PMID:17309078 PMID:18034189

NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592

Enpp2

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

Acetylcysteine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]

PMID:26072274

NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001

Enpp7

ectonucleotide pyrophosphatase/phosphodiesterase 7

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ENPP7 mRNA

NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483

Ep300

E1A binding protein p300

multiple interactions

Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]

PMID:19281832

NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296

Epas1

endothelial PAS domain protein 1

multiple interactions

Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

PMID:23958427

NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265

Epb41

erythrocyte membrane protein band 4.1

multiple interactions

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in decreased expression of EPB41 protein]

PMID:20946910

NCBI chr 5:150,081,727...150,243,186
Ensembl chr 5:150,084,611...150,167,077

Ephb1

Eph receptor B1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPHB1 mRNA

NCBI chr 8:110,376,954...110,813,193
Ensembl chr 8:110,376,954...110,813,000

Eps8

epidermal growth factor receptor pathway substrate 8

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPS8 mRNA

NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882

Ercc8

ERCC excision repair 8, CSA ubiquitin ligase complex subunit

multiple interactions

Acetylcysteine inhibits the reaction [dicrotophos results in decreased expression of ERCC8 protein]

PMID:28302478

NCBI chr 2:39,434,617...39,473,392
Ensembl chr 2:39,434,634...39,472,017

Ern1

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of ERN1 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased phosphorylation of ERN1 protein]
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of ERN1 protein modified form]
Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ERN1 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]

PMID:21198628 PMID:24394546 PMID:25451595 PMID:27784618 PMID:29373603 PMID:30633982 PMID:31330229

NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914

Esr1

estrogen receptor 1

multiple interactions

Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of ESR1 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR1 mRNA]

PMID:18829485 PMID:26149760

NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796

Esr2

estrogen receptor 2

multiple interactions

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR2 mRNA]

NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251

Esrra

estrogen related receptor, alpha

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESRRA protein]

PMID:30104959

NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725

Ets1

ETS proto-oncogene 1, transcription factor

multiple interactions

Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of ETS1 mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of ETS1 mRNA]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETS1 mRNA]

PMID:21635667

NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625

Ezh2

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [EZH2 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of EZH2 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of EZH2 protein]

PMID:24582688 PMID:31551408

NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011

F13a1

coagulation factor XIII A1 chain

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of F13A1 mRNA

NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362

coagulation factor III, tissue factor

multiple interactions

Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]

PMID:23114885

NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272

Fabp4

fatty acid binding protein 4

multiple interactions

Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]

PMID:27117918

NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305

Fadd

Fas associated via death domain

multiple interactions

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of FADD protein]

PMID:20946910

NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628

Fads2

fatty acid desaturase 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FADS2 mRNA

NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524

Fam114a1

family with sequence similarity 114, member A1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM114A1 mRNA

NCBI chr14:44,941,705...45,012,299
Ensembl chr14:44,943,172...45,002,719

Fam114a2

family with sequence similarity 114, member A2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM114A2 mRNA

NCBI chr10:42,893,579...42,933,041

Fam13a

family with sequence similarity 13, member A

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM13A mRNA

NCBI chr 4:89,183,180...89,281,282
Ensembl chr 4:89,183,768...89,281,222

Fam186a

family with sequence similarity 186 member A

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM186A mRNA

NCBI chr 7:141,569,579...141,591,682

Fam189a2

family with sequence similarity 189, member A2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM189A2 mRNA

NCBI chr 1:241,822,152...241,876,089
Ensembl chr 1:241,822,626...241,875,864

Far1

fatty acyl CoA reductase 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAR1 mRNA

NCBI chr 1:178,351,674...178,412,838
Ensembl chr 1:178,351,680...178,431,395

Fas

Fas cell surface death receptor

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of FAS mRNA]
Acetylcysteine results in increased expression of FAS mRNA
Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of FAS protein]; Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of FAS protein]

PMID:9227460 PMID:15382040 PMID:16169029 PMID:19014919 PMID:19477266 PMID:19720122 PMID:21741372 PMID:28219700

NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790

Faslg

Fas ligand

multiple interactions
increases expression

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of FASLG mRNA; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased expression of FASLG protein]
Acetylcysteine results in increased expression of FASLG mRNA
[Atorvastatin co-treated with Acetylcysteine] inhibits the reaction [sodium arsenite results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of FASLG mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of FASLG protein]
Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of FASLG protein]

PMID:11864783 PMID:17574045 PMID:19644561 PMID:19720122 PMID:19760616 PMID:20431929 PMID:20946910 PMID:22429591 PMID:26332274 PMID:28219700

NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705

Fbxo32

F-box protein 32

multiple interactions

Acetylcysteine inhibits the reaction [Indican results in increased expression of FBXO32 protein]

PMID:30849338

NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268

Fer1l5

fer-1-like family member 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FER1L5 mRNA

NCBI chr 9:42,943,362...42,998,126
Ensembl chr 9:42,945,358...42,998,109

Fgf12

fibroblast growth factor 12

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF12 mRNA

NCBI chr11:75,606,360...76,171,078
Ensembl chr11:75,905,443...76,168,989

Fgf2

fibroblast growth factor 2

decreases expression
multiple interactions

Acetylcysteine results in decreased expression of FGF2 mRNA
Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]

PMID:16084531 PMID:19176594

NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681

Fgf21

fibroblast growth factor 21

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA]
Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of FGF21 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased secretion of FGF21 protein]

PMID:22129741 PMID:22917661

NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822

Fgf6

fibroblast growth factor 6

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of FGF6 protein]

NCBI chr 4:159,563,798...159,572,333
Ensembl chr 4:159,563,798...159,572,333

Fgf7

fibroblast growth factor 7

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of FGF7 protein]

NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872

Fhit

fragile histidine triad diadenosine triphosphatase

multiple interactions

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein]

PMID:16585223

NCBI chr15:15,697,292...16,862,873

Filip1l

filamin A interacting protein 1-like

decreases expression

Acetylcysteine results in decreased expression of FILIP1L mRNA

NCBI chr11:45,039,488...45,275,141
Ensembl chr11:45,039,461...45,124,423

Fkbp5

FKBP prolyl isomerase 5

multiple interactions

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of FKBP5 mRNA]

NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020

Flg

filaggrin

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA

NCBI chr 2:193,565,401...193,574,297

Flna

filamin A

multiple interactions

Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]

PMID:25944616

NCBI chr X:156,460,785...156,487,245
Ensembl chr X:156,463,953...156,487,245

Flt1

Fms related receptor tyrosine kinase 1

increases expression
multiple interactions

Acetylcysteine results in increased expression of FLT1 protein
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of FLT1 mRNA]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of FLT1 mRNA]

PMID:17992120 PMID:29408318

NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905

Flt3lg

Fms related receptor tyrosine kinase 3 ligand

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of FLT3LG protein]

NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413

Fmr1

FMRP translational regulator 1

multiple interactions

Acetylcysteine promotes the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

PMID:27385396

NCBI chr X:154,684,924...154,722,369
Ensembl chr X:154,684,935...154,722,314

Fn1

fibronectin 1

multiple interactions

Acetylcysteine inhibits the reaction [Glucose results in increased expression of FN1 protein]
Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP10 protein]; Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP3 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]

PMID:16632126 PMID:17395008 PMID:22245600 PMID:22648416

NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases activity

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS]; Acetylcysteine inhibits the reaction [Etoposide results in increased expression of FOS]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased activity of FOS protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of FOS]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of FOS]
Acetylcysteine results in decreased activity of FOS protein
Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in decreased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of FOS mRNA]; Acetylcysteine promotes the reaction [bis(maltolato)oxovanadium(IV) results in decreased activity of [FOS protein binds to JUN protein]]
Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [oxaliplatin results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of FOS mRNA]

PMID:7743507 PMID:8825185 PMID:8853906 PMID:9043100 PMID:9525474 PMID:10692565 PMID:14623829 PMID:15520183 PMID:16137721 PMID:17696279 PMID:19654923 PMID:20654705 PMID:22129741 PMID:23824011 PMID:24908156

NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299

Fosl1

FOS like 1, AP-1 transcription factor subunit

multiple interactions

Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOSL1 mRNA]

PMID:15520183 PMID:19010381

NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066

Foxd2

forkhead box D2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FOXD2 mRNA

NCBI chr 5:133,707,194...133,710,186
Ensembl chr 5:133,708,228...133,709,712

Foxd4

forkhead box D4

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FOXD4 mRNA

NCBI chr 1:242,808,886...242,810,186
Ensembl chr 1:242,808,965...242,810,186

Foxo1

forkhead box O1

multiple interactions

Acetylcysteine inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of FOXO1 protein modified form]

PMID:23765110

NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016

Foxo3

forkhead box O3

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]
Acetylcysteine inhibits the reaction [tomentosin results in increased expression of FOXO3 protein]
Acetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein]

PMID:20883752 PMID:23159718 PMID:25471227 PMID:30104959 PMID:30917517

NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144

Fshb

follicle stimulating hormone subunit beta

multiple interactions

Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of FSHB protein]

PMID:30633982

NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131

Fth1

ferritin heavy chain 1

multiple interactions

Acetylcysteine inhibits the reaction [Rotenone results in increased expression of FTH1 mRNA]
Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of FTH1 protein]

PMID:18325346 PMID:32687844

NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228

Ftl1

ferritin light chain 1

multiple interactions

Acetylcysteine inhibits the reaction [arsenite results in increased expression of FTL1 protein]

NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829

Fxn

frataxin

affects response to substance

Acetylcysteine affects the susceptibility to FXN protein mutant form

PMID:16120311

NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834

Fyn

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions

Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of FYN protein]
Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]

PMID:12902192 PMID:20850416

NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317

G6pc1

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of G6PC1 mRNA

NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213

G6pd

glucose-6-phosphate dehydrogenase

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]
Acetylcysteine results in increased activity of G6PD protein

PMID:3099627 PMID:12717738 PMID:15225644

NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926

Gadd45a

growth arrest and DNA-damage-inducible, alpha

multiple interactions
decreases expression
increases expression

Acetylcysteine inhibits the reaction [Formaldehyde results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [rhododendrol results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of GADD45A mRNA]
Acetylcysteine results in decreased expression of GADD45A mRNA
Acetylcysteine results in increased expression of GADD45A mRNA
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45A mRNA; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]

PMID:18849615 PMID:22129741 PMID:24291486 PMID:26332274 PMID:26867644

NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842

Gadd45g

growth arrest and DNA-damage-inducible, gamma

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45G mRNA
Acetylcysteine inhibits the reaction [[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G mRNA]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G protein]

PMID:22129741 PMID:23313378

NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243

Galntl5

polypeptide N-acetylgalactosaminyltransferase-like 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GALNTL5 mRNA

NCBI chr 4:6,333,049...6,450,137
Ensembl chr 4:6,333,050...6,449,949

Gap43

growth associated protein 43

multiple interactions

Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]

PMID:18375950

NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914

Gapdh

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

Acetylcysteine results in decreased expression of GAPDH mRNA
Acetylcysteine inhibits the reaction [arsenite results in decreased expression of GAPDH protein]

PMID:11108245 PMID:15175009

NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962

Gata1

GATA binding protein 1

multiple interactions

Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]

PMID:10656287

NCBI chr X:15,273,937...15,281,759
Ensembl chr X:15,378,789...15,382,066

Gbp1

guanylate binding protein 1

decreases expression

Acetylcysteine results in decreased expression of GBP1 mRNA

NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570

Gclc

glutamate-cysteine ligase, catalytic subunit

multiple interactions

Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein]; Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of GCLC protein]; Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of GCLC mRNA]
Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC protein]
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]

PMID:11820781 PMID:11909699 PMID:16631525 PMID:17540521 PMID:17980396 PMID:19328227 PMID:20851755 PMID:21728338 PMID:24355586 PMID:25263748 PMID:30951941 PMID:31029725

NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468

Gclm

glutamate cysteine ligase, modifier subunit

multiple interactions
affects response to substance

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of GCLM mRNA]; Acetylcysteine inhibits the reaction [elesclomol results in increased expression of GCLM mRNA]
GCLM protein affects the susceptibility to Acetylcysteine
Acetylcysteine inhibits the reaction [arsenite results in increased expression of GCLM mRNA]

PMID:17584759 PMID:18723479 PMID:19328227 PMID:19350554

NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874

Gdnf

glial cell derived neurotrophic factor

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GDNF mRNA
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GDNF protein]

PMID:22129741 PMID:26138014

NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238

Gfap

glial fibrillary acidic protein

multiple interactions

Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein]
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of GFAP protein]

PMID:28499986 PMID:31173782

NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506

Ggt1

gamma-glutamyltransferase 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GGT1 mRNA; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased secretion of GGT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]; Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of GGT1 protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]

PMID:12030384 PMID:22129741 PMID:24485406 PMID:24634002

NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068

Gja4

gap junction protein, alpha 4

decreases expression

Acetylcysteine results in decreased expression of GJA4 mRNA

NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221

Gjb1

gap junction protein, beta 1

multiple interactions

Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of GJB1 mRNA]

PMID:32142722

NCBI chr X:71,272,030...71,279,973
Ensembl chr X:71,272,042...71,279,977

glycerol kinase

multiple interactions

Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]

PMID:25449180

NCBI chr X:54,227,291...54,303,897
Ensembl chr X:54,227,397...54,303,864

Gkn2

gastrokine 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GKN2 mRNA

NCBI chr 4:119,131,255...119,177,329
Ensembl chr 4:119,171,245...119,177,329

Glb1

galactosidase, beta 1

multiple interactions

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of GLB1 protein]; Acetylcysteine inhibits the reaction [lopinavir-ritonavir drug combination results in increased activity of GLB1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]

PMID:20884875 PMID:31551408

NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939

Glcci1

glucocorticoid induced 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GLCCI1 mRNA

NCBI chr 4:34,282,625...34,612,709
Ensembl chr 4:34,282,625...34,614,438

Glp1r

glucagon-like peptide 1 receptor

multiple interactions

Acetylcysteine inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein]

PMID:22925809

NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228

Glrx

glutaredoxin

affects response to substance

GLRX protein affects the susceptibility to Acetylcysteine

PMID:17468103

NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944

Glud1

glutamate dehydrogenase 1

multiple interactions

Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of GLUD1 mRNA]

PMID:31857147

NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557

Gnai2

G protein subunit alpha i2

multiple interactions

Acetylcysteine affects the reaction [IER3 protein affects the expression of GNAI2 mRNA]
Acetylcysteine inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI2 protein]

PMID:18441196 PMID:20713914

NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307

Gnai3

G protein subunit alpha i3

multiple interactions

Acetylcysteine inhibits the reaction [Glucose results in decreased expression of GNAI3 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein]

PMID:18441196

NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749

Gp1ba

glycoprotein Ib platelet subunit alpha

multiple interactions

Acetylcysteine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]

NCBI chr10:57,260,680...57,263,546
Ensembl chr10:57,260,680...57,263,546

Gp2

glycoprotein 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GP2 mRNA

NCBI chr 1:189,166,735...189,182,306
Ensembl chr 1:189,166,399...189,182,306

Gpbar1

G protein-coupled bile acid receptor 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPBAR1 mRNA

NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594

Gpc5

glypican 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPC5 mRNA]

NCBI chr15:100,283,131...101,776,838

Gpr153

G protein-coupled receptor 153

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR153 mRNA

NCBI chr 5:169,450,275...169,463,878
Ensembl chr 5:169,452,493...169,462,713

Gpr20

G protein-coupled receptor 20

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR20 mRNA

NCBI chr 7:114,943,675...114,953,977
Ensembl chr 7:114,944,282...114,945,344

Gpr55

G protein-coupled receptor 55

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR55 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPR55 mRNA]

NCBI chr 9:92,961,431...93,011,157
Ensembl chr 9:92,962,738...92,963,697

Gpt

glutamic--pyruvic transaminase

multiple interactions

Acetylcysteine inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]]; IL22 protein promotes the reaction [Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]
[Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Acetylcysteine inhibits the reaction [Cyclosporine results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]]

PMID:17461432 PMID:20688495 PMID:20804811 PMID:23375450 PMID:24485406 PMID:27022031 PMID:27720869 PMID:28435131 PMID:28887131 PMID:29704510 PMID:30423402

NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931

Gpx1

glutathione peroxidase 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein]
Acetylcysteine results in increased expression of GPX1 protein
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]; Acetylcysteine inhibits the reaction [raspberry ketone results in decreased expression of GPX1 protein]; Acetylcysteine inhibits the reaction [rhododendrol results in decreased expression of GPX1 protein]

PMID:25341683 PMID:26867644 PMID:30037311 PMID:30104959

NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522

Gpx2

glutathione peroxidase 2

multiple interactions

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA]

NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245

Gpx4

glutathione peroxidase 4

multiple interactions

Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GPX4 mRNA]

PMID:12208374

NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154

Grin2b

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]

PMID:22824136

NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873

Grm2

glutamate metabotropic receptor 2

increases activity

Acetylcysteine results in increased activity of GRM2 protein

PMID:19136971

NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046

Grm3

glutamate metabotropic receptor 3

increases activity

Acetylcysteine results in increased activity of GRM3 protein

PMID:19136971

NCBI chr 4:21,316,761...21,567,561
Ensembl chr 4:21,317,695...21,560,490

Grm5

glutamate metabotropic receptor 5

increases activity

Acetylcysteine results in increased activity of GRM5 protein

PMID:19136971

NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392

Gsdmd

gasdermin D

multiple interactions

Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of GSDMD protein]

PMID:30378427

NCBI chr 7:116,889,147...116,894,134
Ensembl chr 7:116,889,572...116,894,134

Gsk3b

glycogen synthase kinase 3 beta

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of GSK3B protein]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased phosphorylation of GSK3B protein]

PMID:18569013 PMID:19126599 PMID:24968063 PMID:25246272 PMID:27658547

NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268

Gsr

glutathione-disulfide reductase

multiple interactions

Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GSR mRNA]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in decreased expression of GSR mRNA]
[Acetylcysteine co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein; [Acetylcysteine co-treated with Paraquat] results in increased activity of GSR protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide inhibits the reaction [GSR protein results in increased oxidation of NADP]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of GSR mRNA]; Acetylcysteine inhibits the reaction [Dimethylnitrosamine results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [Paraquat results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of GSR protein]; Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in decreased activity of GSR protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]]; Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [EUK-134 results in decreased activity of GSR protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in decreased activity of GSR protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]]

PMID:16631525 PMID:19840221 PMID:21114986 PMID:23159886 PMID:24634002 PMID:25724285 PMID:26079211 PMID:30951941

NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361

Gsta1

glutathione S-transferase alpha 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA]

PMID:9152014

NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902

Gsta4

glutathione S-transferase alpha 4

multiple interactions

[Acetylcysteine co-treated with EUK-134] promotes the reaction [[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein]; [EUK-134 co-treated with Acetylcysteine] promotes the reaction [Paraquat results in increased activity of GSTA4 protein]; [EUK-134 co-treated with Acetylcysteine] promotes the reaction [Zinc Sulfate results in increased activity of GSTA4 protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Paraquat results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]

PMID:23159886 PMID:25724285 PMID:30639957

NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879

Gsta5

glutathione S-transferase alpha 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTA5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA]

NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179

Gstm1

glutathione S-transferase mu 1

multiple interactions

Acetylcysteine inhibits the reaction [alpha-methylepinine results in increased expression of GSTM1 mRNA]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTM1 mRNA

PMID:21871945 PMID:22129741

NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306

Gstm2

glutathione S-transferase mu 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTM2 mRNA

NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856

Gstp1

glutathione S-transferase pi 1

multiple interactions

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTP1 mRNA]

NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147

Gulp1

GULP PTB domain containing engulfment adaptor 1

decreases expression

Acetylcysteine results in decreased expression of GULP1 mRNA

NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072

Gypa

glycophorin A

multiple interactions

Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]

NCBI chr19:31,115,545...31,131,079

H2ax

H2A.X variant histone

multiple interactions

Acetylcysteine inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [alpha-terthienylmethanol results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [LAQ824 results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [PCB 180 metabolite results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]
Acetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]
Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein]

PMID:15173094 PMID:15489221 PMID:18852132 PMID:19409983 PMID:21135414 PMID:22172632 PMID:23274516 PMID:24614525 PMID:25633853 PMID:26079211 PMID:26148434 PMID:28300663 PMID:28506552 PMID:28993908 PMID:29128613 PMID:29416738 PMID:30408460

NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981

Has2

hyaluronan synthase 2

multiple interactions

Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]

PMID:21220312

NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049

Hax1

HCLS1 associated protein X-1

multiple interactions

Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein]

PMID:19679660

NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322

Hbegf

heparin-binding EGF-like growth factor

multiple interactions

Acetylcysteine inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA]

PMID:12676768

NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403

Herpud1

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression
multiple interactions

Acetylcysteine results in increased expression of HERPUD1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HERPUD1 mRNA]

PMID:16084531 PMID:18723479

NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254

Hgf

hepatocyte growth factor

multiple interactions

Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of HGF protein]

PMID:16757516

NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362

Hhip

Hedgehog-interacting protein

multiple interactions

[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of HHIP mRNA

NCBI chr19:31,525,134...31,614,487
Ensembl chr19:31,524,671...31,614,246

Hif1a

hypoxia inducible factor 1 subunit alpha

multiple interactions

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein]
Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Nickel analog results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]]
1-(2-chloroethyl)-1-nitrosourea inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of HIF1A mRNA]; Acetylcysteine inhibits the reaction [Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HIF1A mRNA]; Acetylcysteine inhibits the reaction [Cisplatin affects the localization of HIF1A protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Fluorouracil affects the localization of HIF1A protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of HIF1A mRNA]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]

PMID:10866824 PMID:11641398 PMID:11886167 PMID:13679210 PMID:16530163 PMID:17015263 PMID:17066447 PMID:17658243 PMID:19374849 PMID:19410601 PMID:21036805 PMID:22648416 PMID:22700867 PMID:25406100 PMID:27297870 PMID:29408318 PMID:31850806

NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052

Hk2

hexokinase 2

increases expression

Acetylcysteine results in increased expression of HK2 mRNA

NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243

Hmbs

hydroxymethylbilane synthase

multiple interactions

Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]

PMID:10656287

NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748

Hmga2

high mobility group AT-hook 2

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMGA2 protein]

PMID:27071802

NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408

Hmgb1

high mobility group box 1

multiple interactions

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HMGB1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]

PMID:26079697 PMID:30977640

NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237

Hmgb2

high mobility group box 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of HMGB2 mRNA

NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191

Hmgcr

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]

PMID:19931295

NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654

Hmox1

heme oxygenase 1

increases expression
multiple interactions
affects activity

Acetylcysteine results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [2,2'-dihydroxychalcone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide results in increased abundance of Peroxides] which results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[monomethylarsonous acid results in increased abundance of Peroxides] which results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [carnosol results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [chromium trioxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal results in increased expression of HMOX1]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Urea results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]; Polymyxin B inhibits the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]]
[Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [2-xylene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Acetylcysteine inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Benzene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cannabidiol results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [chloropicrin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Silicon analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Silver analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [sulforafan results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Toluene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [Oxygen results in increased expression of HMOX1 mRNA]
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; Acetylcysteine affects the reaction [Glucose affects the expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [oxophenylarsine results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]
Acetylcysteine affects the activity of HMOX1 protein
Acetylcysteine results in increased expression of HMOX1 mRNA; Acetylcysteine results in increased expression of HMOX1 protein

PMID:7538129 PMID:9152014 PMID:9545559 PMID:9747510 PMID:10975858 PMID:11103787 PMID:11592956 PMID:12420312 PMID:12690112 PMID:12699905 PMID:12763371 PMID:14687664 PMID:15175009 PMID:15368090 PMID:15541757 PMID:16137721 PMID:16171798 PMID:16274885 PMID:16631525 PMID:16806455 PMID:16890772 PMID:16959797 PMID:17540521 PMID:17979524 PMID:18077580 PMID:18156441 PMID:18332044 PMID:18336854 PMID:18357586 PMID:18586083 PMID:18723479 PMID:18830972 PMID:19033392 PMID:19136476 PMID:19323979 PMID:19350554 PMID:19642688 PMID:19654923 PMID:20020861 PMID:20054154 PMID:20934533 PMID:20938987 PMID:21144877 PMID:21238556 PMID:21384399 PMID:21397656 PMID:21787718 PMID:22019695 PMID:22263782 PMID:22507881 PMID:22564156 PMID:22643931 PMID:22659318 PMID:22714038 PMID:22917016 PMID:23900960 PMID:23942037 PMID:24126012 PMID:24291486 PMID:24355171 PMID:24361488 PMID:24401988 PMID:24489685 PMID:25003661 PMID:25246272 PMID:26163453 PMID:26169828 PMID:26291278 PMID:26404762 PMID:26542248 PMID:26658076 PMID:26945724 PMID:26968795 PMID:27151894 PMID:27393915 PMID:27658547 PMID:27725188 PMID:27777014 PMID:27867098 PMID:28013216 PMID:28555929 PMID:29086419 PMID:29111403 PMID:29155359 PMID:29540228 PMID:30104959 PMID:30349652 PMID:30633982 PMID:30951941 PMID:30965051 PMID:31029725 PMID:31790703 PMID:31884112 PMID:32525552 PMID:32708634

NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456

Hnf4g

hepatocyte nuclear factor 4, gamma

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of HNF4G mRNA

NCBI chr 2:100,225,880...100,372,710
Ensembl chr 2:100,225,888...100,372,252

Hras

HRas proto-oncogene, GTPase

multiple interactions

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA]
Acetylcysteine inhibits the reaction [HRAS protein mutant form results in increased susceptibility to sodium arsenite]

PMID:15945272 PMID:25199681

NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686

Hsbp1

heat shock factor binding protein 1

multiple interactions

Acetylcysteine inhibits the reaction [Thioacetamide results in increased expression of HSBP1 protein]

PMID:17103249

NCBI chr19:51,985,196...51,989,528
Ensembl chr19:51,985,170...51,989,544

Hsd11b2

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD11B2 mRNA]

NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307

Hsd17b3

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD17B3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]

PMID:26769589 PMID:29567110

NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745

Hsd17b8

hydroxysteroid (17-beta) dehydrogenase 8

multiple interactions

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD17B8 mRNA]

NCBI chr20:3,817,212...3,819,316
Ensembl chr20:3,817,179...3,819,235

Hsd3b3

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

multiple interactions

Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD3B3 mRNA]

PMID:26769589

NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492

Hsf1

heat shock transcription factor 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter affects the localization of HSF1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]]; Acetylcysteine inhibits the reaction [Vehicle Emissions affects the localization of HSF1 protein]

PMID:10403520 PMID:17922515 PMID:30309986

NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478

Hsp90b1

heat shock protein 90 beta family member 1

multiple interactions

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSP90B1 mRNA]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSP90B1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSP90B1 protein]
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 protein]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]

PMID:21145380 PMID:21533816 PMID:21911445 PMID:25451595 PMID:25950987 PMID:31330229

NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533

Hspa1a

heat shock protein family A (Hsp70) member 1A

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1A mRNA]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of HSPA1A protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of HSPA1A mRNA]

PMID:12231548 PMID:16324719 PMID:18723479

NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779

Hspa1b

heat shock protein family A (Hsp70) member 1B

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1B mRNA]
Acetylcysteine inhibits the reaction [arsenite results in increased expression of HSPA1B protein]

PMID:15175009 PMID:18723479

NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815

Hspa5

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions
decreases expression

Acetylcysteine results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]
Acetylcysteine results in decreased expression of HSPA5 protein
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [discretamine results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Ethylmercury Compounds affects the expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]

PMID:19722195 PMID:20493918 PMID:21145380 PMID:21198628 PMID:21533816 PMID:21911445 PMID:24157283 PMID:24291486 PMID:24802810 PMID:25341683 PMID:25451595 PMID:25950987 PMID:26772155 PMID:27484784 PMID:27511942 PMID:27784618 PMID:27816613 PMID:28296042 PMID:28754437 PMID:30502353 PMID:30633982 PMID:31276663 PMID:31330229 PMID:32590070

NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762

Hspb1

heat shock protein family B (small) member 1

multiple interactions

Acetylcysteine inhibits the reaction [arsenite results in increased expression of HSPB1 protein]

NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049

Hspd1

heat shock protein family D (Hsp60) member 1

multiple interactions

PMID:32092105

NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956

Htatip2

HIV-1 Tat interactive protein 2

decreases expression

Acetylcysteine results in decreased expression of HTATIP2 mRNA

NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461

Icam1

intercellular adhesion molecule 1

affects expression
multiple interactions
decreases expression

Acetylcysteine affects the expression of ICAM1
Acetylcysteine affects the reaction [Dinitrochlorobenzene affects the expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]
Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]
Acetylcysteine results in decreased expression of ICAM1 mRNA
Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased secretion of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]

PMID:10495789 PMID:10792388 PMID:11736926 PMID:17416599 PMID:17666914 PMID:19642688 PMID:20885979 PMID:23114885 PMID:25876056 PMID:26683377 PMID:26901245 PMID:29329563 PMID:30842373

NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059

Id2

inhibitor of DNA binding 2

decreases expression

Acetylcysteine results in decreased expression of ID2 mRNA

NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915

Idh2

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein]

PMID:30104959

NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705

Ier3

immediate early response 3

multiple interactions
affects response to substance

Acetylcysteine affects the reaction [IER3 protein affects the expression of GNAI2 mRNA]
IER3 protein affects the susceptibility to Acetylcysteine

PMID:20713914

NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769

Ier5

immediate early response 5

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IER5 mRNA]

NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303

Ifng

interferon gamma

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IFNG protein]; Acetylcysteine inhibits the reaction [Eosine I Bluish results in increased expression of IFNG mRNA]; Acetylcysteine inhibits the reaction [Formaldehyde results in decreased expression of IFNG mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IFNG protein]
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IFNG protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]

PMID:12847270 PMID:15004186 PMID:18849615 PMID:20431929 PMID:22440610 PMID:24810974 PMID:26138014 PMID:32620109

NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419

Ifrd1

interferon-related developmental regulator 1

multiple interactions

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IFRD1 mRNA]

NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420

Igf1

insulin-like growth factor 1

multiple interactions

Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGF1 protein]

PMID:17458902 PMID:26138014

NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609

Igf1r

insulin-like growth factor 1 receptor

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IGF1R protein]

PMID:21195169

NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516

Igfbp1

insulin-like growth factor binding protein 1

multiple interactions

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IGFBP1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGFBP1 protein]

PMID:22129741 PMID:26138014

NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785

Igfbp2

insulin-like growth factor binding protein 2

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of IGFBP2 protein]

NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789

Igfbp4

insulin-like growth factor binding protein 4

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of IGFBP4 protein]

NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578

Ikbkb

inhibitor of nuclear factor kappa B kinase subunit beta

decreases activity

Acetylcysteine results in decreased activity of IKBKB protein

PMID:17395010

NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815

Il10

interleukin 10

multiple interactions

[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL10 protein]
Acetylcysteine inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Acetylcysteine promotes the reaction [Doxorubicin results in increased expression of IL10 mRNA]

PMID:11124598 PMID:20431929 PMID:20885979 PMID:21237301 PMID:21424515 PMID:26138014 PMID:32620109

NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392

Il10rb

interleukin 10 receptor subunit beta

decreases expression

Acetylcysteine results in decreased expression of IL10RB mRNA

NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457

Il12a

interleukin 12A

multiple interactions

Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]

PMID:21237301

NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318

Il12b

interleukin 12B

multiple interactions

Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]

PMID:21237301

NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085

Il13

interleukin 13

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL13 protein]

NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466

Il15

interleukin 15

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL15 protein]

NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594

Il16

interleukin 16

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL16 protein]

NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912

Il17a

interleukin 17A

multiple interactions

Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL17A protein]; Acetylcysteine inhibits the reaction [Trichloroethylene results in increased expression of IL17A mRNA]

PMID:20431929 PMID:23993974

NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786

Il17d

interleukin 17D

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IL17D mRNA

NCBI chr15:37,790,211...37,807,653
Ensembl chr15:37,790,141...37,807,660

Il18

interleukin 18

multiple interactions

Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]
Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]

PMID:27311643 PMID:30205151

NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299

Il1a

interleukin 1 alpha

multiple interactions

[Acetylcysteine co-treated with IL1A protein] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [butylphen results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA]; Acetylcysteine promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein]]

PMID:7476933 PMID:24570342 PMID:26138014 PMID:28836394

NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086

Il1b

interleukin 1 beta

multiple interactions
decreases expression
affects expression

Acetylcysteine analog inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL1B protein]; Acetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of IL1B protein modified form]; Acetylcysteine inhibits the reaction [2,4-decadienal results in increased expression of and results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [[Oligomycins co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; Acetylcysteine inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of IL1B protein modified form]; Acetylcysteine inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein]; Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Acetylcysteine promotes the reaction [titanium dioxide results in increased secretion of IL1B protein]
Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of and results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased secretion of IL1B protein]
Acetylcysteine results in decreased expression of IL1B mRNA
Acetylcysteine affects the expression of IL1B protein

PMID:10541287 PMID:11970852 PMID:16014734 PMID:16214328 PMID:18257742 PMID:18403674 PMID:19281832 PMID:21424515 PMID:21703343 PMID:21779360 PMID:22385246 PMID:22549761 PMID:22867088 PMID:23159886 PMID:23900960 PMID:23940760 PMID:23948867 PMID:24570342 PMID:24609059 PMID:24810974 PMID:25406100 PMID:26086368 PMID:26138014 PMID:26332274 PMID:26435000 PMID:26809137 PMID:26901245 PMID:27311643 PMID:27393034 PMID:27783111 PMID:28004443 PMID:28814068 PMID:30205151 PMID:30320338 PMID:30639957 PMID:30878009 PMID:30977640 PMID:31629901 PMID:32620109

NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726

Il2

interleukin 2

multiple interactions

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of IL2 mRNA; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of IL2 protein]
Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of IL2 protein]

PMID:22429591 PMID:22910795 PMID:31173782

NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854

Il24

interleukin 24

decreases activity

Acetylcysteine results in decreased activity of IL24 protein

PMID:14678967

NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849

Il27ra

interleukin 27 receptor subunit alpha

decreases expression

Acetylcysteine results in decreased expression of IL27RA mRNA

NCBI chr19:25,151,835...25,163,995
Ensembl chr19:25,149,897...25,164,086

Il2ra

interleukin 2 receptor subunit alpha

multiple interactions

Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]

PMID:23134680

NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071

Il3

interleukin 3

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL3 protein]

NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973

Il4

interleukin 4

multiple interactions

Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL4 protein]

PMID:26138014 PMID:27634759

NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531

Il4r

interleukin 4 receptor

multiple interactions

Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL4R mRNA]

PMID:29753051

NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220

Il5

interleukin 5

multiple interactions

Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL5 protein]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL5 protein]

PMID:20431929 PMID:26138014

NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587

Il6

interleukin 6

multiple interactions

Acetylcysteine analog inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL6 protein]; Acetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [calcium silicate results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]

PMID:9378980 PMID:10022265 PMID:11970852 PMID:16757516 PMID:17922515 PMID:18257742 PMID:20801209 PMID:21131394 PMID:21424515 PMID:21533553 PMID:21762757 PMID:21779360 PMID:21912612 PMID:22472292 PMID:23624824 PMID:24570342 PMID:24810974 PMID:26160521 PMID:27427241 PMID:27917510 PMID:28555929 PMID:28739487 PMID:29329563 PMID:29753051 PMID:30259999

NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807

Ins2

insulin 2

multiple interactions

Acetylcysteine inhibits the reaction [Glucose results in increased expression of INS protein]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]
Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]]

PMID:16505238 PMID:21888768 PMID:28180948

NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034

Insig1

insulin induced gene 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of INSIG1 mRNA

NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515

Insr

insulin receptor

multiple interactions

Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of INSR protein]
Acetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]

PMID:18569013 PMID:22917016

NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414

Ireb2

iron responsive element binding protein 2

multiple interactions

Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]

PMID:18073202

NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118

Irf1

interferon regulatory factor 1

multiple interactions

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRF1 mRNA

PMID:20525893 PMID:22129741

NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531

Irs1

insulin receptor substrate 1

multiple interactions

Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]

PMID:17458902

NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488

Irs2

insulin receptor substrate 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA

NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684

Itga2

integrin subunit alpha 2

multiple interactions

Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of ITGA2 mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of ITGA2 mRNA]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA]

PMID:21635667

NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961

Itga2b

integrin subunit alpha 2b

multiple interactions

Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]; Acetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]

NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070

Itgam

integrin subunit alpha M

multiple interactions

Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of ITGAM mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of ITGAM mRNA]]

PMID:29945211

NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960

Itgav

integrin subunit alpha V

decreases expression

Acetylcysteine results in decreased expression of ITGAV mRNA

NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411

Itgb1

integrin subunit beta 1

multiple interactions

Acetylcysteine inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]

PMID:24820114

NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535

Itgb3

integrin subunit beta 3

multiple interactions

Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]; Acetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]

NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410

Jag1

jagged canonical Notch ligand 1

decreases expression
multiple interactions

Acetylcysteine results in decreased expression of JAG1 mRNA
Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of JAG1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of JAG1 mRNA]

PMID:16084531 PMID:20974985

NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770

Jak1

Janus kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]

PMID:24820114

NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904

Jak2

Janus kinase 2

multiple interactions

Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]
Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of JAK2 protein]

PMID:12847270 PMID:29894800

NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

decreases activity
multiple interactions

Acetylcysteine results in decreased activity of JUN protein
Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [8-bromo-7-methoxychrysin results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with Disulfiram] results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [afimoxifene results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of JUN]; Acetylcysteine inhibits the reaction [darinaparsin results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of JUN protein]
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Chromium results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; Acetylcysteine inhibits the reaction [zinc chloride results in increased expression of JUN mRNA]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of JUN mRNA]; Acetylcysteine promotes the reaction [bis(maltolato)oxovanadium(IV) results in decreased activity of [FOS protein binds to JUN protein]]

PMID:7743507 PMID:8797811 PMID:8825185 PMID:8853906 PMID:9043100 PMID:9890986 PMID:10397638 PMID:10692565 PMID:11306679 PMID:15252869 PMID:15520183 PMID:15945272 PMID:17458902 PMID:17696279 PMID:18569013 PMID:18633430 PMID:19038359 PMID:19292871 PMID:19654923 PMID:19747498 PMID:19935718 PMID:20632440 PMID:20654705 PMID:21635667 PMID:22260869 PMID:22288910 PMID:23033007 PMID:24750999 PMID:30796935 PMID:31229567 PMID:32540572

NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277

Junb

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA]

PMID:15520183

NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756

Ka11

type I keratin KA11

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KA11 mRNA

NCBI chr10:88,141,667...88,144,624
Ensembl chr10:88,141,667...88,144,625

Kcnh5

potassium voltage-gated channel subfamily H member 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KCNH5 mRNA

NCBI chr 6:97,872,831...98,157,087
Ensembl chr 6:97,872,831...98,157,087

Kcnq5

potassium voltage-gated channel subfamily Q member 5

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KCNQ5 mRNA

NCBI chr 9:27,565,869...28,141,114
Ensembl chr 9:27,562,959...27,761,733

Kctd4

potassium channel tetramerization domain containing 4

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KCTD4 mRNA

NCBI chr15:58,006,288...58,021,166
Ensembl chr15:58,016,238...58,019,442

Kdm2a

lysine demethylase 2A

multiple interactions

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of KDM2A protein]
Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [KDM2A protein binds to CDKN2A promoter]]

PMID:31551408

NCBI chr 1:219,566,130...219,642,294
Ensembl chr 1:219,566,156...219,640,294

Kdr

kinase insert domain receptor

increases expression

Acetylcysteine results in increased expression of KDR protein

PMID:17992120

NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183

Keap1

Kelch-like ECH-associated protein 1

multiple interactions

Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein]; Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]

PMID:11909699 PMID:19033392 PMID:30104959

NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779

Kif2c

kinesin family member 2C

multiple interactions

Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of KIF2C protein]

PMID:28343997

NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210

Kitlg

KIT ligand

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of KITLG protein]

NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054

Klotho

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of KL protein]
Acetylcysteine results in increased expression of KL protein
Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA]; Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL protein]

PMID:21389697 PMID:23183129 PMID:23765110

NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551

Kmt2a

lysine methyltransferase 2A

multiple interactions

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of KMT2A protein]

PMID:31551408

NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971

Kras

KRAS proto-oncogene, GTPase

multiple interactions

Acetylcysteine inhibits the reaction [manumycin results in decreased activity of KRAS protein]

PMID:19409983

NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558

Kremen2

kringle containing transmembrane protein 2

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KREMEN2 mRNA

NCBI chr10:13,076,042...13,081,210
Ensembl chr10:13,076,679...13,081,136

Krt10

keratin 10

multiple interactions

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of KRT10 protein]

PMID:31551408

NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736

Krt6a

keratin 6A

multiple interactions

Acetylcysteine inhibits the reaction [titanium dioxide results in decreased expression of KRT6A mRNA]

PMID:20932892

Krt8

keratin 8

multiple interactions

Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased phosphorylation of KRT8 protein]

PMID:15939799

NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803

Lamp1

lysosomal-associated membrane protein 1

multiple interactions

Acetylcysteine inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LAMP1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of LAMP1 mRNA]

PMID:28347754 PMID:29307831 PMID:31319114

NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419

Ldha

lactate dehydrogenase A

multiple interactions

Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]
Acetylcysteine inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of LDHA mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of LDHA mRNA]

PMID:21671307 PMID:31251971 PMID:31724279

NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707

Ldhb

lactate dehydrogenase B

multiple interactions

Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

PMID:21671307

NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012

Lgalsl

galectin-like

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LGALSL mRNA

NCBI chr14:105,047,915...105,055,421
Ensembl chr14:105,047,919...105,055,421

Lhb

luteinizing hormone subunit beta

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Acetylcysteine results in increased expression of LHB protein
Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of LHB protein]

PMID:21220312 PMID:30633982

NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724

Lhx8

LIM homeobox 8

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LHX8 mRNA

NCBI chr 2:260,572,205...260,598,744
Ensembl chr 2:260,574,190...260,596,777

Lipe

lipase E, hormone sensitive type

multiple interactions

Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of LIPE protein]

PMID:30648648

NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727

LOC100912990

beta-defensin 12-like

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DEFB12 mRNA

NCBI chr16:75,109,946...75,110,960
Ensembl chr16:75,118,002...75,120,417

LOC103689977

caspase-6

multiple interactions

Acetylcysteine inhibits the reaction [arsenic trioxide results in increased activity of CASP6 protein]

PMID:24157283

NCBI chr 2:230,186,170...230,198,555
Ensembl chr 2:230,186,198...230,198,555

Lpin1

lipin 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LPIN1 mRNA

NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046

Ly9

lymphocyte antigen 9

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LY9 mRNA

NCBI chr13:90,002,779...90,022,346
Ensembl chr13:90,002,783...90,022,269

Lyplal1

lysophospholipase-like 1

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LYPLAL1 mRNA

NCBI chr13:104,049,263...104,080,680
Ensembl chr13:104,049,386...104,080,631

Lyzl4

lysozyme-like 4

multiple interactions

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LYZL4 mRNA

NCBI chr 8:130,219,984...130,228,066
Ensembl chr 8:130,220,018...130,224,444

Madcam1

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

Acetylcysteine inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

PMID:12388057

NCBI chr 7:12,918,352...12,922,509
Ensembl chr 7:12,918,710...12,922,112

Map1lc3b

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased metabolism of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Vorinostat results in increased cleavage of MAP1LC3B protein]
Acetylcysteine inhibits the reaction [cupric chloride results in increased expression of MAP1LC3B protein modified form]; Acetylcysteine inhibits the reaction [Indican results in increased expression of MAP1LC3B protein]
Acetylcysteine inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]; Acetylcysteine inhibits the reaction [cadmium acetate affects the localization of [RAB7A protein co-treated with MAP1LC3B protein]]; Acetylcysteine inhibits the reaction [nonylphenol results in increased expression of MAP1LC3B protein]

PMID:20543569 PMID:25301941 PMID:27832966 PMID:28347754 PMID:28600121 PMID:29247770 PMID:29307831 PMID:30849338 PMID:31319114 PMID:32512069 PMID:32687844

NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058

Map2

microtubule-associated protein 2

multiple interactions

Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA]
Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]

PMID:28153600 PMID:28499986

NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972

Map2k1

mitogen activated protein kinase kinase 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein]

NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758

Map2k2

mitogen activated protein kinase kinase 2

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489

Map2k3

mitogen activated protein kinase kinase 3

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K3 protein]

NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753

Map2k4

mitogen activated protein kinase kinase 4

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]
Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]

PMID:18703135 PMID:22085843

NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657

Map2k6

mitogen-activated protein kinase kinase 6

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K6 protein]

NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287

Map3k5

mitogen-activated protein kinase kinase kinase 5

multiple interactions

Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]; Acetylcysteine inhibits the reaction [platycodin D affects the phosphorylation of and results in increased activity of MAP3K5 protein]; Acetylcysteine inhibits the reaction [Quercetin results in decreased phosphorylation of and results in increased activity of MAP3K5 protein]

PMID:16449798 PMID:18703135 PMID:20083342 PMID:22784044

NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746

Mapk1

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
decreases phosphorylation

Acetylcysteine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [antimony trichloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [ceric oxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [dihydromyricetin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Thimerosal results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [YM 155 results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK1 protein; Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Acetylcysteine affects the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[cobaltous chloride results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [NGF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [raiser results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Acetylcysteine results in increased phosphorylation of MAPK1 protein]
Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]
Acetylcysteine results in decreased phosphorylation of MAPK1 protein

PMID:8616849 PMID:10658192 PMID:12065697 PMID:12690112 PMID:12717738 PMID:14516795 PMID:14623829 PMID:15228596 PMID:15252869 PMID:15978937 PMID:16014620 PMID:16024921 PMID:16251475 PMID:16261333 PMID:16445087 PMID:16603213 PMID:16632126 PMID:16983658 PMID:17458902 PMID:17596522 PMID:17645304 PMID:17828457 PMID:18357586 PMID:18375950 PMID:18495191 PMID:18629305 PMID:18703135 PMID:19038359 PMID:19747498 PMID:20951154 PMID:21055460 PMID:21135414 PMID:21145380 PMID:21220312 PMID:21391979 PMID:21533816 PMID:21549813 PMID:21843585 PMID:21998720 PMID:22085843 PMID:22134701 PMID:22288910 PMID:22700867 PMID:22767315 PMID:22867088 PMID:22910795 PMID:23370007 PMID:23405080 PMID:23416263 PMID:23577223 PMID:23774252 PMID:23836369 PMID:23876460 PMID:24019090 PMID:24401988 PMID:24463199 PMID:24582688 PMID:25199686 PMID:25246272 PMID:25531190 PMID:25724548 PMID:25876056 PMID:26514923 PMID:27539140 PMID:28555929 PMID:28600122 PMID:28867437 PMID:29087013 PMID:29155359 PMID:29248572 PMID:29248592 PMID:29486182 PMID:30055241 PMID:30766661 PMID:30849338 PMID:30871965 PMID:30917517 PMID:31068539 PMID:31313457 PMID:31724279 PMID:31790703 PMID:31837377 PMID:32305283 PMID:32683294

NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254

Mapk10

mitogen activated protein kinase 10

multiple interactions

Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in increased phosphorylation of and results in increased activity of MAPK10 protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in increased phosphorylation of and results in increased activity of MAPK10 protein]

PMID:15173093

NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254

Mapk13

mitogen activated protein kinase 13

multiple interactions

Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of MAPK13 protein]

PMID:28087840

NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473

Mapk14

mitogen activated protein kinase 14

multiple interactions

Acetylcysteine inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Emodin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK14 protein]

PMID:12684028 PMID:14729614 PMID:15650392 PMID:17237268 PMID:18703135 PMID:19767766 PMID:21635667 PMID:28087840

NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137

Mapk3

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions
decreases phosphorylation