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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-methyl-N'-nitro-N-nitrosoguanidine
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Accession:CHEBI:21759 term browser browse the term
Definition:An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Synonyms:related_synonym: 1-Methyl-1-nitroso-3-nitroguanidine;   1-Methyl-3-nitro-1-nitrosoguanidine;   1-Nitroso-3-nitro-1-methylguanidine;   Formula=C2H5N5O3;   InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4);   InChIKey=VZUNGTLZRAYYDE-UHFFFAOYSA-N;   MNG;   MNNG;   Methylnitronitrosoguanidine;   N'-Nitro-N-nitroso-N-methylguanidine;   N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide;   N-Methyl-N-nitroso-N'-nitroguanidine;   N-Methyl-N-nitrosonitroguanidin;   SMILES=CN(N=O)C(=N)N[N+]([O-])=O
 alt_id: CHEBI:34872
 xref: Beilstein:1779490;   CAS:70-25-7;   KEGG:C14592
 xref_mesh: MESH:D008769


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N-methyl-N'-nitro-N-nitrosoguanidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ABL1 mRNA CTD PMID:19840844 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846 		JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of ACOX2 mRNA CTD PMID:15120970 NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ADAM10 mRNA CTD PMID:12634122 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AGT mRNA CTD PMID:19840844 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases localization 		ISO benzamide inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein]; phenanthridone inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein] CTD PMID:15589979 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA] 		CTD PMID:35103375 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alb albumin decreases secretion EXP Methylnitronitrosoguanidine results in decreased secretion of ALB protein CTD PMID:15772367 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ALDH1A1 mRNA CTD PMID:19840844 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Methylnitronitrosoguanidine results in increased expression of ALPL mRNA CTD PMID:12634122 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of AMBP mRNA CTD PMID:12773770 NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850 		JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ANXA5 mRNA CTD PMID:19840844 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects response to substance
multiple interactions
decreases expression 		ISO APAF1 protein affects the susceptibility to Methylnitronitrosoguanidine
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein] 		CTD PMID:16019050 PMID:20434464 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases expression ISO Methylnitronitrosoguanidine results in increased expression of APC mRNA CTD PMID:12634122 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of APP mRNA CTD PMID:19840844 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of ARAF mRNA CTD PMID:12634122 NCBI chr  X:3,780,932...3,845,919
Ensembl chr  X:3,780,932...3,792,611 		JBrowse link
G Atm ATM serine/threonine kinase increases response to substance ISO ATM gene mutant form results in increased susceptibility to Methylnitronitrosoguanidine CTD PMID:15010311 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of ATP1B3 mRNA CTD PMID:12634122 NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:65,253,361...65,254,304
Ensembl chr 8:65,253,361...65,254,304 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein] CTD PMID:26921499 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of AXL mRNA CTD PMID:12634122 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
multiple interactions
decreases phosphorylation 		ISO Methylnitronitrosoguanidine results in decreased expression of BAD mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA]
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of BAD protein] 		CTD PMID:17828454 PMID:20434464 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bag1 BAG cochaperone 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of BAG1 mRNA CTD PMID:12634122 NCBI chr 5:60,864,476...60,877,059
Ensembl chr 5:60,864,476...60,878,161 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO BAK1 protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib] CTD PMID:18376143 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BAX protein; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
BAX protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Methylnitronitrosoguanidine results in decreased expression of BAX mRNA; Methylnitronitrosoguanidine results in decreased expression of BAX protein 		CTD PMID:16030430 PMID:18376143 PMID:20434464 PMID:35103375 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BCAT2 mRNA CTD PMID:19840844 NCBI chr 1:105,175,157...105,196,474
Ensembl chr 1:105,176,977...105,196,463 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression 		ISO
EXP 		Methylnitronitrosoguanidine results in decreased expression of BCL2 protein
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA; Methylnitronitrosoguanidine results in increased expression of BCL2 protein
weifuchun affects the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein] 		CTD PMID:16019050 PMID:16030430 PMID:20434464 PMID:35103375 PMID:36403744 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression 		ISO BCL2L1 protein results in decreased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA] 		CTD PMID:18376143 PMID:20434464 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions EXP [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein] CTD PMID:16030430 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methylnitronitrosoguanidine results in increased expression of BDNF mRNA CTD PMID:15120970 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Bgn biglycan multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BGN mRNA CTD PMID:19840844 NCBI chr  X:156,348,633...156,360,797
Ensembl chr  X:156,348,615...156,360,799 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression 		ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA] CTD PMID:20434464 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of BIRC2 mRNA CTD PMID:12634122 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Blvrb biliverdin reductase B multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BLVRB mRNA CTD PMID:19840844 NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:91,866,258...91,884,225 		JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of BMP4 mRNA CTD PMID:12773770 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Methylnitronitrosoguanidine results in increased expression of BRCA1 mRNA CTD PMID:12634122 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Brca2 BRCA2, DNA repair associated increases expression ISO Methylnitronitrosoguanidine results in increased expression of BRCA2 mRNA CTD PMID:12634122 NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194 		JBrowse link
G Bsg basigin multiple interactions
increases expression 		EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BSG mRNA] CTD PMID:35103375 NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of BTG2 protein CTD PMID:24821435 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G C1qb complement C1q B chain increases expression EXP Methylnitronitrosoguanidine results in increased expression of C1QB mRNA CTD PMID:15120970 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840 		JBrowse link
G C1s complement C1s increases expression EXP Methylnitronitrosoguanidine results in increased expression of C1S mRNA CTD PMID:15120970 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736 		JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CALM1 mRNA CTD PMID:19840844 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
decreases expression 		ISO
EXP 		Methylnitronitrosoguanidine results in increased activity of CASP3 protein
[Methylnitronitrosoguanidine co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in increased activity of CASP3 protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Methylnitronitrosoguanidine results in increased activity of CASP3 protein]
Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA; Methylnitronitrosoguanidine results in decreased expression of CASP3 protein 		CTD PMID:15589979 PMID:16019050 PMID:16030430 PMID:17428624 PMID:20434464 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp4 caspase 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CASP4 mRNA CTD PMID:12634122 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein] CTD PMID:16030430 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
decreases expression 		ISO
EXP 		Methylnitronitrosoguanidine results in increased activity of CASP9 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein] 		CTD PMID:15589979 PMID:16019050 PMID:20434464 PMID:35103375 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases activity 		EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased activity of CAT protein] CTD PMID:35103375 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbx5 chromobox 5 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CBX5 mRNA CTD PMID:12634122 NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:136,211,649...136,229,118 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CCNA1 mRNA CTD PMID:12634122 NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
decreases expression 		EXP
ISO 		Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCNB1 mRNA
Methylnitronitrosoguanidine results in decreased expression of CCNB1 mRNA 		CTD PMID:11516527 PMID:12135628 PMID:19851710 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		EXP
ISO 		Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA]
Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA; Methylnitronitrosoguanidine results in increased expression of CCND1 protein
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCND1 protein 		CTD PMID:12135628 PMID:19851710 PMID:21628965 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CCNG1 mRNA CTD PMID:11516527 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Ccnh cyclin H increases expression ISO Methylnitronitrosoguanidine results in increased expression of CCNH mRNA CTD PMID:12634122 NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCT2 mRNA CTD PMID:19840844 NCBI chr 7:54,578,654...54,591,428
Ensembl chr 7:54,578,663...54,592,977 		JBrowse link
G Cd14 CD14 molecule increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of CD14 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CD14 protein] 		CTD PMID:36403744 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd59b CD59b molecule increases mutagenesis ISO Methylnitronitrosoguanidine results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:110,914,091...110,935,310 		JBrowse link
G Cd9 CD9 molecule multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD9 mRNA CTD PMID:19840844 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression 		EXP
ISO 		geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]
Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA; Methylnitronitrosoguanidine results in decreased expression of CDH1 protein
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA] 		CTD PMID:28428697 PMID:38184286 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]
Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA; Methylnitronitrosoguanidine results in increased expression of CDH2 protein
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 protein] 		CTD PMID:38184286 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdh8 cadherin 8 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CDH8 mRNA CTD PMID:12634122 NCBI chr19:5,494,552...5,901,950
Ensembl chr19:5,500,221...5,902,627 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression
multiple interactions 		EXP
ISO 		Methylnitronitrosoguanidine results in increased expression of CDK4 protein
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CDK4 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDK4 protein] 		CTD PMID:12135628 PMID:21628965 PMID:36403744 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CDK5 mRNA CTD PMID:12634122 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions 		ISO
EXP 		Methylnitronitrosoguanidine results in decreased expression of CDKN1A mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein] 		CTD PMID:12634122 PMID:19851710 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA
Methylnitronitrosoguanidine results in increased expression of CDKN1B protein
Cadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDKN1B protein]; Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA] 		CTD PMID:11516527 PMID:12135628 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cep43 centrosomal protein 43 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CEP43 mRNA CTD PMID:12634122 NCBI chr 1:55,080,983...55,111,509
Ensembl chr 1:55,082,712...55,111,509 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein] CTD PMID:26921499 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein] CTD PMID:26921499 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G Ckb creatine kinase B decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CKB mRNA CTD PMID:12634122 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478 		JBrowse link
G Clta clathrin, light chain A multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CLTA mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CLTA mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CLTA mRNA CTD PMID:19840844 NCBI chr 5:63,022,046...63,059,223
Ensembl chr 5:63,041,184...63,059,215 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL1A2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL1A2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL1A2 mRNA CTD PMID:19840844 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL6A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL6A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL6A1 mRNA CTD PMID:19840844 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107 		JBrowse link
G Col8a1 collagen type VIII alpha 1 chain multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL8A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL8A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL8A1 mRNA CTD PMID:19840844 NCBI chr11:56,245,998...56,378,586
Ensembl chr11:56,369,868...56,376,229 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of COX6A1 mRNA CTD PMID:19840844 NCBI chr12:46,922,709...46,925,762
Ensembl chr12:46,912,648...46,925,768 		JBrowse link
G Cox8a cytochrome c oxidase subunit 8A multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of COX8A mRNA CTD PMID:19840844 NCBI chr 1:213,831,302...213,833,623
Ensembl chr 1:213,831,298...213,833,623 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression 		EXP geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CTNNB1 mRNA] CTD PMID:28428697 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of CTSB mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of CTSB mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CTSB mRNA CTD PMID:19840844 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CTSL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CTSL mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CTSL mRNA CTD PMID:19840844 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CXCL12 mRNA CTD PMID:19840844 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CXCR4 mRNA CTD PMID:12634122 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyb561d2 cytochrome b561 family, member D2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CYB561D2 mRNA CTD PMID:12634122 NCBI chr 8:117,091,844...117,094,434
Ensembl chr 8:117,091,845...117,094,366 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases expression 		ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS protein]
Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA; Methylnitronitrosoguanidine results in decreased expression of CYCS protein 		CTD PMID:20434464 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of DAB2 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:57,242,064...57,294,888 		JBrowse link
G Dcn decorin decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of DCN mRNA CTD PMID:15120970 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926 		JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of DEAF1 mRNA CTD PMID:12634122 NCBI chr 1:205,831,428...205,865,106
Ensembl chr 1:205,831,336...205,865,106 		JBrowse link
G Dek DEK proto-oncogene increases expression ISO Methylnitronitrosoguanidine results in increased expression of DEK mRNA CTD PMID:12634122 NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of DLG1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of DLG1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DLG1 mRNA CTD PMID:19840844 NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797 		JBrowse link
G Dstn destrin, actin depolymerizing factor increases expression ISO Methylnitronitrosoguanidine results in increased expression of DSTN mRNA CTD PMID:12634122 NCBI chr 3:151,737,711...151,764,752
Ensembl chr 3:151,737,849...151,764,769 		JBrowse link
G Dut deoxyuridine triphosphatase affects localization
increases secretion 		ISO Methylnitronitrosoguanidine affects the localization of DUT protein
Methylnitronitrosoguanidine results in increased secretion of DUT protein 		CTD PMID:21658424 NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of E2F1 protein
ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; E2F1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein results in increased expression of RRM2 mRNA] 		CTD PMID:26921499 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO [[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; [Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHIR-124 inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; E2F3 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]] CTD PMID:26921499 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725 		JBrowse link
G Egf epidermal growth factor affects activity
multiple interactions 		ISO Methylnitronitrosoguanidine affects the activity of EGF protein
Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein]; Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] 		CTD PMID:15708576 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor affects localization
multiple interactions 		ISO Methylnitronitrosoguanidine affects the localization of EGFR protein
Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] 		CTD PMID:15708576 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EGR1 mRNA CTD PMID:19840844 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF1 mRNA CTD PMID:19840844 NCBI chr10:85,747,064...85,749,447
Ensembl chr 5:25,895,968...25,896,654
Ensembl chr10:25,895,968...25,896,654 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E increases expression ISO Methylnitronitrosoguanidine results in increased expression of EIF3E mRNA CTD PMID:12634122 NCBI chr 7:76,224,567...76,257,346
Ensembl chr 7:76,224,568...76,257,785 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of EIF5 mRNA CTD PMID:12634122 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EIF5A mRNA CTD PMID:19840844 NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330 		JBrowse link
G Elk3 ETS transcription factor ELK3 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ELK3 mRNA CTD PMID:12634122 NCBI chr 7:29,655,676...29,718,163
Ensembl chr 7:29,655,693...29,691,661 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of EMP1 mRNA CTD PMID:12634122 NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:169,931,440...169,964,365 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of ENPP2 mRNA CTD PMID:15120970 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957 		JBrowse link
G Epcam epithelial cell adhesion molecule increases expression ISO Methylnitronitrosoguanidine results in increased expression of EPCAM mRNA CTD PMID:12634122 NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702 		JBrowse link
G Epha1 Eph receptor A1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of EPHA1 mRNA CTD PMID:12634122 NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474 		JBrowse link
G Ephb3 Eph receptor B3 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of EPHB3 mRNA CTD PMID:12634122 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775 		JBrowse link
G Eps8 EGFR pathway substrate 8, signaling adaptor multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EPS8 mRNA CTD PMID:19840844 NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:172,119,497...172,218,160 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ERBB2 mRNA CTD PMID:12634122 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ERBB4 mRNA CTD PMID:12634122 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772 		JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of ESR2 mRNA; Methylnitronitrosoguanidine results in increased expression of ESR2 protein CTD PMID:21628965 PMID:22330348 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO Methylnitronitrosoguanidine results in increased expression of ETS1 mRNA CTD PMID:12634122 NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021 		JBrowse link
G Faslg Fas ligand decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of FASLG protein CTD PMID:24821435 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Methylnitronitrosoguanidine results in increased expression of FASN mRNA CTD PMID:12634122 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fau FAU ubiquitin like and ribosomal protein S30 fusion multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of FAU mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of FAU mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FAU mRNA CTD PMID:19840844 NCBI chr 1:212,779,429...212,781,028
Ensembl chr 1:212,779,473...212,781,026
Ensembl chr 1:212,779,473...212,781,026 		JBrowse link
G Fcer1a Fc epsilon receptor Ia increases expression EXP Methylnitronitrosoguanidine results in increased expression of FCER1A mRNA CTD PMID:15120970 NCBI chr13:88,218,427...88,224,723
Ensembl chr13:88,218,420...88,224,681 		JBrowse link
G Fcgr2a Fc gamma receptor 2A increases expression EXP Methylnitronitrosoguanidine results in increased expression of FCGR3 mRNA CTD PMID:15120970 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394 		JBrowse link
G Fcgrt Fc gamma receptor and transporter decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of FCGRT mRNA CTD PMID:12634122 NCBI chr 1:104,710,902...104,720,685
Ensembl chr 1:104,710,909...104,720,532 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of FES mRNA CTD PMID:12634122 NCBI chr 1:143,746,945...143,756,181
Ensembl chr 1:143,746,945...143,756,181 		JBrowse link
G Fgf10 fibroblast growth factor 10 increases expression EXP Methylnitronitrosoguanidine results in increased expression of FGF10 mRNA CTD PMID:15120970 NCBI chr 2:52,533,939...52,610,980
Ensembl chr 2:52,533,939...52,610,980 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases expression 		EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA] CTD PMID:20434464 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Folr1 folate receptor alpha increases methylation ISO Methylnitronitrosoguanidine results in increased methylation of FOLR1 promoter CTD PMID:29644877 NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in decreased expression of FOSL1 mRNA
Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein results in increased expression of RRM2 mRNA] 		CTD PMID:12634122 PMID:26921499 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G Fst follistatin increases expression EXP Methylnitronitrosoguanidine results in increased expression of FST mRNA CTD PMID:15120970 NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:47,856,345...47,863,491 		JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of FSTL1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of FSTL1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FSTL1 mRNA CTD PMID:19840844 NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of FYN mRNA CTD PMID:12634122 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA] 		CTD PMID:19851710 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gcgr glucagon receptor decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of GCGR mRNA CTD PMID:15120970 NCBI chr10:106,306,803...106,314,970
Ensembl chr10:106,306,559...106,314,969 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Methylnitronitrosoguanidine results in increased expression of GDF15 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GJA1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GJA1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GJA1 mRNA CTD PMID:19840844 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of GJB2 mRNA CTD PMID:15120970 NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877 		JBrowse link
G Gli1 GLI family zinc finger 1 increases expression EXP MNNG increases expression of Gli1 mRNA in rat stomach RGD PMID:30537251 RGD:150520178 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540 		JBrowse link
G Gpc4 glypican 4 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GPC4 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GPC4 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GPC4 mRNA CTD PMID:19840844 NCBI chr  X:136,565,536...136,676,142
Ensembl chr  X:136,565,591...136,676,057 		JBrowse link
G Gss glutathione synthetase decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of GSS mRNA CTD PMID:12634122 NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GSTM2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GSTM2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GSTM2 mRNA CTD PMID:19840844 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gsto1 glutathione S-transferase omega 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTO1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTO1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTO1 mRNA CTD PMID:19840844 NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTP1 mRNA CTD PMID:19840844 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Gtf2i general transcription factor II I multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [GTF2I protein binds to RRM2 promoter] CTD PMID:26921499 NCBI chr12:28,037,344...28,112,677
Ensembl chr12:28,037,853...28,112,677 		JBrowse link
G Gzmf granzyme F increases expression EXP Methylnitronitrosoguanidine results in increased expression of GZMG mRNA CTD PMID:15120970 NCBI chr15:33,975,543...33,997,505
Ensembl chr15:33,977,505...33,997,572 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form
[[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; E2F3 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; RRM2 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form] 		CTD PMID:26921499 PMID:27233451 PMID:38563870 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of H4C2 mRNA CTD PMID:12634122 NCBI chr 2:183,831,601...183,831,996
Ensembl chr 4:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of HBA1 mRNA CTD PMID:15120970 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of HES1 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HES1 protein] 		CTD PMID:36403744 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 multiple interactions
increases expression 		EXP weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HES6 protein] CTD PMID:36403744 NCBI chr 9:99,449,375...99,451,343
Ensembl chr 9:99,449,371...99,451,096 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA; Methylnitronitrosoguanidine results in increased expression of HIF1A protein
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA]; weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A protein] 		CTD PMID:35103375 PMID:36403744 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions 		ISO
EXP 		Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA] 		CTD PMID:12634122 PMID:35103375 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of HMGB2 mRNA CTD PMID:12634122 NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of HPGD mRNA CTD PMID:15120970 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HPRT1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of HPRT1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HPRT1 mRNA CTD PMID:19840844 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:137,655,680...137,687,712 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein] CTD PMID:15708576 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AA1 mRNA CTD PMID:19840844 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AB1 mRNA CTD PMID:19840844 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of HSP90B1 mRNA CTD PMID:12634122 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of HSPA1A mRNA CTD PMID:15120970 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSPD1 mRNA CTD PMID:19840844 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases response to substance
increases expression
multiple interactions 		ISO ICAM1 protein results in decreased susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in increased expression of ICAM1 mRNA; Methylnitronitrosoguanidine results in increased expression of ICAM1 protein
prolinedithiocarbamate inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of ICAM1 protein] 		CTD PMID:22001597 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of ID1 mRNA CTD PMID:12634122 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IER3 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IER3 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IER3 mRNA CTD PMID:19840844 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of IFITM1 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:205,496,807...205,498,776 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of IFRD1 mRNA CTD PMID:12634122 NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131 		JBrowse link
G Igkc immunoglobulin kappa constant increases expression EXP Methylnitronitrosoguanidine results in increased expression of IGKC mRNA CTD PMID:15120970
G Igsf6 immunoglobulin superfamily, member 6 increases expression EXP Methylnitronitrosoguanidine results in increased expression of IGSF6 mRNA CTD PMID:15120970 NCBI chr 1:185,041,462...185,051,956
Ensembl chr 1:185,041,462...185,052,245 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
increases expression 		EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein] CTD PMID:19851710 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased secretion of IL1B protein
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL1B protein] 		CTD PMID:38184286 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression 		ISO
EXP 		weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased secretion of IL6 protein]
Methylnitronitrosoguanidine results in increased expression of IL6 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IL6 protein]
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL6 protein] 		CTD PMID:36403744 PMID:38184286 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IRAK1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IRAK1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IRAK1 mRNA CTD PMID:19840844 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825 		JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of ITGB4 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,705,587...101,741,932 		JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of JMJD6 mRNA CTD PMID:19840844 NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,539,894...102,545,986 		JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of JPT1 mRNA CTD PMID:19840844 NCBI chr10:101,243,428...101,261,464
Ensembl chr10:101,243,424...101,261,469 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 increases expression EXP Methylnitronitrosoguanidine results in increased expression of KCTD12 mRNA CTD PMID:15120970 NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539 		JBrowse link
G Kdm8 lysine demethylase 8 multiple interactions ISO Methylnitronitrosoguanidine inhibits the reaction [TP53 protein binds to KDM8 protein] CTD PMID:26025680 NCBI chr 1:189,444,527...189,459,507
Ensembl chr 1:189,444,555...189,459,491 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of KIT mRNA CTD PMID:12634122 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812 		JBrowse link
G Kitlg KIT ligand decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of KITLG mRNA CTD PMID:15120970 NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793 		JBrowse link
G Klf10 KLF transcription factor 10 decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of KLF10 mRNA CTD PMID:15120970 NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948 		JBrowse link
G Klf7 KLF transcription factor 7 multiple interactions
increases expression 		ISO KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SNAI1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TWIST1 protein]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KLF7 mRNA]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KLF7 protein]
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 mRNA]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of CDH2 mRNA]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of SNAI1 protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TWIST1 protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of VIM mRNA]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased phosphorylation of RELA protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL1B protein]; KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased secretion of IL6 protein]
Methylnitronitrosoguanidine results in increased expression of KLF7 mRNA; Methylnitronitrosoguanidine results in increased expression of KLF7 protein 		CTD PMID:38184286 NCBI chr 9:72,927,485...73,020,167
Ensembl chr 9:72,933,136...73,020,056 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
increases expression 		EXP geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KRAS mRNA] CTD PMID:28428697 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Krt17 keratin 17 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of KRT17 mRNA CTD PMID:12634122 NCBI chr10:85,679,068...85,683,792
Ensembl chr10:85,679,070...85,683,787 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression 		EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of LDHA mRNA] CTD PMID:35103375 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lgals3 galectin 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LGALS3 mRNA CTD PMID:19840844 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737 		JBrowse link
G Lgals8 galectin 8 increases expression ISO Methylnitronitrosoguanidine results in increased expression of LGALS8 mRNA CTD PMID:12634122 NCBI chr17:62,716,368...62,744,272
Ensembl chr17:62,719,828...62,744,482 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of LIG1 mRNA CTD PMID:12634122 NCBI chr 1:83,243,043...83,281,707
Ensembl chr 1:83,219,545...83,281,708 		JBrowse link
G Lipa lipase A, lysosomal acid type increases expression EXP Methylnitronitrosoguanidine results in increased expression of LIP1 mRNA CTD PMID:15120970 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740 		JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LOX mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LOX mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LOX mRNA CTD PMID:19840844 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LPL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LPL mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LPL mRNA CTD PMID:19840844 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA] 		CTD PMID:28428697 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MAP3K12 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MAP3K12 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MAP3K12 mRNA CTD PMID:19840844 NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:135,508,790...135,515,137 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation 		ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK1 protein]] CTD PMID:17828454 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Methylnitronitrosoguanidine results in increased phosphorylation of MAPK14 protein CTD PMID:22001597 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation 		ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK3 protein]] CTD PMID:17828454 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk4 mitogen-activated protein kinase 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MAPK4 mRNA CTD PMID:12634122 NCBI chr18:69,788,058...69,937,524
Ensembl chr18:69,788,060...69,837,037 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Methylnitronitrosoguanidine results in increased phosphorylation of MAPK8 protein CTD PMID:22001597 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MAPK9 mRNA CTD PMID:12634122 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of MARCKS mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of MARCKS mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MARCKS mRNA CTD PMID:19840844 NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882 		JBrowse link
G Max MYC associated factor X increases expression ISO Methylnitronitrosoguanidine results in increased expression of MAX mRNA CTD PMID:12634122 NCBI chr 6:101,369,989...101,395,333
Ensembl chr 6:101,369,988...101,395,549 		JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO Methylnitronitrosoguanidine results in increased expression of MCAM mRNA CTD PMID:12634122 PMID:12773770 NCBI chr 8:53,376,225...53,384,407
Ensembl chr 8:53,376,197...53,384,406 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in decreased expression of MCM2 mRNA
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM2 mRNA 		CTD PMID:12634122 PMID:19840844 NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:122,903,682...122,918,094 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MCM4 mRNA CTD PMID:12634122 NCBI chr11:98,762,599...98,776,300
Ensembl chr11:98,762,634...98,776,536 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM6 mRNA CTD PMID:19840844 NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467 		JBrowse link
G Mcpt1 mast cell protease 1 increases expression EXP Methylnitronitrosoguanidine results in increased expression of MCPT1 mRNA CTD PMID:15120970 NCBI chr15:33,841,606...33,844,174
Ensembl chr15:33,841,606...33,844,174 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of MDM2 mRNA
Methylnitronitrosoguanidine results in increased expression of MDM2 protein
Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] 		CTD PMID:12135628 PMID:12634122 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Mecom MDS1 and EVI1 complex locus increases expression ISO Methylnitronitrosoguanidine results in increased expression of MECOM mRNA CTD PMID:12634122 NCBI chr 2:114,837,815...115,393,052
Ensembl chr 2:114,837,840...115,393,038 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of MET mRNA CTD PMID:12634122 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:1727384 PMID:15010311 PMID:16043385 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MGST2 mRNA CTD PMID:12634122 NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:137,836,140...137,866,661 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MGST3 mRNA CTD PMID:19840844 NCBI chr13:82,059,480...82,080,418
Ensembl chr13:82,059,480...82,080,575 		JBrowse link
G Mir21 microRNA 21 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MIR21 mRNA CTD PMID:24821435 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MKI67 protein CTD PMID:38563870 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MLH1 protein CTD PMID:17671175 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression 		EXP
ISO 		Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP2 mRNA]; Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein
[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MMP2 mRNA 		CTD PMID:19840844 PMID:20434464 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression 		EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP9 mRNA]; Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein CTD PMID:20434464 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases response to substance ISO MPG protein results in increased susceptibility to Methylnitronitrosoguanidine CTD PMID:15299078 NCBI chr10:15,900,697...15,906,981
Ensembl chr10:15,899,635...15,907,052 		JBrowse link
G Mpp1 MAGUK p55 scaffold protein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of MPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of MPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MPP1 mRNA CTD PMID:19840844
G Msh2 mutS homolog 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MSH2 mRNA CTD PMID:12634122 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503 		JBrowse link
G Mst1 macrophage stimulating 1 increases expression EXP Methylnitronitrosoguanidine results in increased expression of MST1 mRNA CTD PMID:15120970 NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015 		JBrowse link
G Mt1a metallothionein 1A multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MT1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MT1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MT1 mRNA CTD PMID:19840844 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases methylation ISO Methylnitronitrosoguanidine results in increased methylation of MTHFR promoter CTD PMID:29644877 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
G Mutyh mutY DNA glycosylase multiple interactions ISO MUTYH protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PARP1 protein] CTD PMID:26954031 NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:135,517,695...135,522,776 		JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of MX2 mRNA CTD PMID:12082013 NCBI chr11:50,375,101...50,399,373
Ensembl chr11:50,375,191...50,402,478 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MYBL1 mRNA CTD PMID:12634122 NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of MYC protein
Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MYC protein] 		CTD PMID:12135628 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Myl2 myosin light chain 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MYL2 mRNA CTD PMID:12634122 NCBI chr12:40,114,964...40,126,236
Ensembl chr12:40,114,958...40,129,149 		JBrowse link
G Myl9 myosin light chain 9 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MYL9 mRNA CTD PMID:12634122 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410 		JBrowse link
G Mylk myosin light chain kinase decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MYLK mRNA CTD PMID:12634122 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of NBL1 mRNA CTD PMID:12634122 NCBI chr 5:156,601,986...156,613,182
Ensembl chr 5:156,601,986...156,613,186 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression 		EXP
ISO 		Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA; Methylnitronitrosoguanidine results in increased expression of NFKB1 protein
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein] 		CTD PMID:19851710 PMID:38184286 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
increases expression 		EXP
ISO 		Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]
Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA; Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein
Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased degradation of NFKBIA protein 		CTD PMID:19851710 PMID:22001597 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nfya nuclear transcription factor Y subunit alpha multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [NFYA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYA protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 9:20,085,067...20,111,521
Ensembl chr 9:20,085,073...20,111,504 		JBrowse link
G Nfyb nuclear transcription factor Y subunit beta multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [NFYB protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYB protein results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein] CTD PMID:26921499 NCBI chr 7:22,852,543...22,868,116
Ensembl chr 7:22,852,546...22,882,294 		JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [NFYC protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYC protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 5:139,622,020...139,690,545
Ensembl chr 5:139,622,020...139,679,884 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases activity EXP Methylnitronitrosoguanidine results in increased activity of NNMT protein CTD PMID:6652621 NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174 		JBrowse link
G Nrp1 neuropilin 1 increases expression EXP Methylnitronitrosoguanidine results in increased expression of NRP1 mRNA CTD PMID:15120970 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ODC1 mRNA CTD PMID:19840844 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PA2G4 mRNA CTD PMID:19840844 NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:1,569,327...1,576,802 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase multiple interactions
affects response to substance 		ISO [Hydrolyzable Tannins results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; [nobotanin B results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; benzamide inhibits the reaction [PARG affects the susceptibility to Methylnitronitrosoguanidine] CTD PMID:11593040 PMID:15591342 NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,442,726...7,550,584 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
affects cleavage
increases response to substance
increases expression 		ISO [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; [Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD; benzamide inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein]; Hydrolyzable Tannins inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; MUTYH protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PARP1 protein]
PARP1 protein results in increased susceptibility to Methylnitronitrosoguanidine 		CTD PMID:11593040 PMID:20434464 PMID:22001597 PMID:26954031 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PCBP2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PCBP2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCBP2 mRNA CTD PMID:19840844 NCBI chr 7:135,483,702...135,508,254
Ensembl chr 7:135,483,856...135,509,412 		JBrowse link
G Pcdh7 protocadherin 7 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PCDH7 mRNA CTD PMID:12634122 NCBI chr14:56,684,817...57,114,976
Ensembl chr14:56,687,725...57,112,665 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
increases expression 		ISO
EXP 		Methylnitronitrosoguanidine results in decreased expression of PCNA mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]; geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PCNA mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PCNA mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA mRNA; Cadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PCNA mRNA]; Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]
Methylnitronitrosoguanidine results in increased expression of PCNA mRNA; Methylnitronitrosoguanidine results in increased expression of PCNA protein 		CTD PMID:11516527 PMID:12135628 PMID:12634122 PMID:19840844 PMID:19851710 More... NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO Methylnitronitrosoguanidine results in increased expression of PDGFB mRNA CTD PMID:12634122 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PDGFRA mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PDGFRA mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PDGFRA mRNA CTD PMID:19840844 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PDIA3 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PDIA3 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDIA3 mRNA CTD PMID:19840844 NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PEA15 mRNA CTD PMID:12634122 NCBI chr13:87,190,189...87,199,811
Ensembl chr13:87,187,295...87,199,859 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PGK1 mRNA CTD PMID:12634122 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:75,336,687...75,352,959 		JBrowse link
G Pgr progesterone receptor decreases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in decreased expression of PGR protein
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PGR protein] 		CTD PMID:28428697 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of PIK3CG mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3CG mRNA] 		CTD PMID:35103375 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA] 		CTD PMID:28428697 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Plxna3 plexin A3 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PLXNA3 mRNA CTD PMID:12634122 NCBI chr  X:157,266,986...157,282,896
Ensembl chr  X:157,267,107...157,282,891 		JBrowse link
G Podxl podocalyxin-like multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PODXL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PODXL mRNA CTD PMID:19840844 NCBI chr 4:61,102,434...61,149,131
Ensembl chr 4:61,102,419...61,149,789 		JBrowse link
G Postn periostin decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of POSTN mRNA CTD PMID:15120970 NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases response to substance ISO PPP2R2A protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:25772433 NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma increases response to substance ISO PPP2R5C protein results in increased susceptibility to Methylnitronitrosoguanidine CTD PMID:25772433 NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:135,324,067...135,419,597 		JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon decreases response to substance ISO PPP2R5E protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:25772433 NCBI chr 6:99,904,569...100,053,672
Ensembl chr 6:99,904,569...100,053,573 		JBrowse link
G Prkd1 protein kinase D1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PRKD1 mRNA CTD PMID:12634122 NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509 		JBrowse link
G Pten phosphatase and tensin homolog decreases response to substance
decreases expression
multiple interactions 		ISO
EXP 		PTEN protein results in decreased susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in decreased expression of PTEN protein
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PTEN protein] 		CTD PMID:20530668 PMID:28428697 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptn pleiotrophin multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PTN mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PTN mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTN mRNA CTD PMID:19840844 NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PTP4A1 mRNA CTD PMID:12634122 NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PTPRA mRNA CTD PMID:12634122 NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:138,098,110...138,213,126 		JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PTPRG mRNA CTD PMID:12634122 NCBI chr15:15,298,669...15,982,581
Ensembl chr15:15,302,133...15,982,668 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PTPRS mRNA CTD PMID:12634122 NCBI chr 9:1,332,558...1,394,161
Ensembl chr 9:1,332,559...1,394,093 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PTTG1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PTTG1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTTG1 mRNA CTD PMID:19840844 NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309 		JBrowse link
G Pura purine rich element binding protein A multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [PURA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [PURA protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr18:28,159,103...28,179,539
Ensembl chr18:28,125,126...28,211,111 		JBrowse link
G Racgap1 Rac GTPase-activating protein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RACGAP1 mRNA CTD PMID:19840844 NCBI chr 7:132,629,789...132,659,738
Ensembl chr 7:132,620,595...132,659,738 		JBrowse link
G Rad21 RAD21 cohesin complex component multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RAD21 mRNA CTD PMID:19840844 NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:85,177,716...85,204,657 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of RAD23A mRNA CTD PMID:12634122 PMID:12773770 NCBI chr19:40,219,235...40,225,543
Ensembl chr19:40,219,636...40,225,543 		JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit increases expression ISO Methylnitronitrosoguanidine results in increased expression of RBBP5 mRNA CTD PMID:12634122 NCBI chr13:46,464,389...46,494,244
Ensembl chr13:46,464,389...46,491,238 		JBrowse link
G Rbm6 RNA binding motif protein 6 increases expression ISO Methylnitronitrosoguanidine results in increased expression of RBM6 mRNA CTD PMID:12634122 NCBI chr 8:117,327,607...117,431,397
Ensembl chr 8:117,331,325...117,431,397 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions
decreases expression 		EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein]
Methylnitronitrosoguanidine results in decreased expression of RECK mRNA; Methylnitronitrosoguanidine results in decreased expression of RECK protein 		CTD PMID:20434464 NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
increases phosphorylation 		EXP
ISO 		Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]
Methylnitronitrosoguanidine results in increased expression of RELA mRNA; Methylnitronitrosoguanidine results in increased expression of RELA protein
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased phosphorylation of RELA protein]
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein] 		CTD PMID:19851710 PMID:38184286 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Reln reelin increases expression EXP Methylnitronitrosoguanidine results in increased expression of RELN mRNA CTD PMID:15120970 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162 		JBrowse link
G Rgs18 regulator of G-protein signaling 18 increases expression EXP Methylnitronitrosoguanidine results in increased expression of RGS18 mRNA CTD PMID:15120970 NCBI chr13:59,043,431...59,066,342
Ensembl chr13:59,043,431...59,066,342 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression EXP Methylnitronitrosoguanidine results in increased expression of ROS1 mRNA CTD PMID:15120970 NCBI chr20:31,975,328...32,126,675
Ensembl chr20:31,975,329...32,126,547 		JBrowse link
G Rpl7 ribosomal protein L7 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of RPL7 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RPL7 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of RPL7 mRNA CTD PMID:19840844 NCBI chr 5:8,000,446...8,003,454
Ensembl chr 5:7,850,630...8,003,451 		JBrowse link
G Rps11 ribosomal protein S11 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of RPS11 mRNA CTD PMID:19840844 NCBI chr 1:104,742,153...104,744,261
Ensembl chr 1:104,742,155...104,744,337 		JBrowse link
G Rps20 ribosomal protein S20 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of RPS20 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RPS20 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of RPS20 mRNA CTD PMID:19840844 NCBI chr 5:21,616,687...21,618,068
Ensembl chr 3:42,839,965...43,095,621
Ensembl chr 9:42,839,965...43,095,621
Ensembl chr 5:42,839,965...43,095,621 		JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Methylnitronitrosoguanidine results in increased expression of RPSA mRNA CTD PMID:12773770 NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:128,728,862...128,732,737 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA
[[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; [Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; CHIR-124 inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [DP1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [DP1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [GTF2I protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [IFI16 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [IFI16 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [NFYA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYA protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [NFYB protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYB protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [NFYC protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYC protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [PURA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [PURA protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [YY1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [YY1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine results in increased expression of and affects the localization of RRM2 protein; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; RRM2 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form] 		CTD PMID:26921499 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression
affects expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA
Methylnitronitrosoguanidine affects the expression of RRM2B mRNA
ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; E2F1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine results in increased expression of and affects the localization of RRM2B protein; TP53 protein mutant form inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein] 		CTD PMID:21704725 PMID:26921499 NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of HLA-DRB1 mRNA CTD PMID:12634122 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 4:122,489,754...122,524,666
Ensembl chr 4:122,489,680...122,524,665 		JBrowse link
G Sec61g Sec61 translocon subunit gamma multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SEC61G mRNA CTD PMID:19840844 NCBI chr14:95,113,083...95,119,458
Ensembl chr 9:48,798,504...48,798,710
Ensembl chr14:48,798,504...48,798,710 		JBrowse link
G Selenop selenoprotein P multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of SELENOP mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of SELENOP mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SELENOP mRNA CTD PMID:19840844 NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:54,225,152...54,236,019 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Methylnitronitrosoguanidine results in increased expression of SERPINE1 mRNA CTD PMID:15120970 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Serping1 serpin family G member 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of SERPING1 mRNA CTD PMID:12634122 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of SLC16A3 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SLC16A3 mRNA] 		CTD PMID:35103375 NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903 		JBrowse link
G Smad2 SMAD family member 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of SMAD2 mRNA CTD PMID:12634122 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression EXP MNNG increases expression of Smo mRNA in rat stomach RGD PMID:30537251 RGD:150520178 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281 		JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of SNAI1 protein
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of SNAI1 protein]
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SNAI1 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SNAI1 protein] 		CTD PMID:38184286 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snora62 small nucleolar RNA, H/ACA box 62 increases expression ISO Methylnitronitrosoguanidine results in increased expression of SNORA62 mRNA CTD PMID:12773770 NCBI chr 8:119,853,958...119,854,106
Ensembl chr 8:128,731,591...128,731,739 		JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N increases expression ISO Methylnitronitrosoguanidine results in increased expression of SNRPN mRNA CTD PMID:12634122 NCBI chr 1:120,316,846...120,338,919
Ensembl chr 1:120,315,556...120,323,924 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of SPARC mRNA CTD PMID:12634122 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of SPINK1 mRNA CTD PMID:12634122 NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545 		JBrowse link
G Spint2 serine peptidase inhibitor, Kunitz type, 2 decreases expression
increases expression 		ISO Methylnitronitrosoguanidine results in decreased expression of SPINT2 mRNA
Methylnitronitrosoguanidine results in increased expression of SPINT2 mRNA 		CTD PMID:12634122 NCBI chr 1:93,685,637...93,708,091
Ensembl chr 1:93,685,641...93,708,091 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SPP1 mRNA CTD PMID:19840844 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Sqle squalene epoxidase increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of SQLE mRNA
[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SQLE mRNA 		CTD PMID:12634122 PMID:19840844 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of SRSF7 mRNA CTD PMID:12634122 NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:20,564,044...20,571,212 		JBrowse link
G Stk39 serine threonine kinase 39 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of STK39 mRNA CTD PMID:12634122 NCBI chr 3:73,321,522...73,588,397
Ensembl chr 3:73,321,522...73,586,740 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling decreases expression EXP MNNG decreases expression of Sufu mRNA in rat stomach RGD PMID:30537251 RGD:150520178 NCBI chr 1:255,199,108...255,296,983
Ensembl chr 1:255,199,164...255,296,981 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SUMO2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SUMO2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SUMO2 mRNA CTD PMID:19840844 NCBI chr10:101,270,899...101,283,458
Ensembl chr10:101,270,900...101,283,938
Ensembl chr 5:101,270,900...101,283,938 		JBrowse link
G Syn1 synapsin I multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SYN1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SYN1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SYN1 mRNA CTD PMID:19840844 NCBI chr  X:3,725,745...3,780,940
Ensembl chr  X:3,725,714...3,780,938 		JBrowse link
G Tbrg4 transforming growth factor beta regulator 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TBRG4 mRNA CTD PMID:12634122 NCBI chr14:85,696,738...85,704,691
Ensembl chr14:85,695,893...85,704,659 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of TGFB1 mRNA
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TGFB1 mRNA] 		CTD PMID:28428697 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS1 mRNA CTD PMID:19840844 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402 		JBrowse link
G Thbs2 thrombospondin 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA CTD PMID:19840844 NCBI chr 1:64,343,523...64,372,918
Ensembl chr 1:64,343,523...64,372,918 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TIAM1 mRNA CTD PMID:12634122 NCBI chr11:42,517,527...42,866,280
Ensembl chr11:42,517,528...42,646,075 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression
multiple interactions 		EXP
ISO 		Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA; Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TIMP2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TIMP2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TIMP2 mRNA 		CTD PMID:19840844 PMID:20434464 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of TLR2 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TLR2 protein] 		CTD PMID:36403744 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression EXP Methylnitronitrosoguanidine results in increased expression of TLR4 mRNA CTD PMID:15120970 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TMSB4X mRNA CTD PMID:19840844 NCBI chr  X:30,761,611...30,763,612
Ensembl chr  X:30,761,612...30,763,613 		JBrowse link
G Tnc tenascin C increases expression ISO Methylnitronitrosoguanidine results in increased expression of TNC mRNA CTD PMID:12634122 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions 		EXP
ISO 		Methylnitronitrosoguanidine results in increased expression of TNF protein
Methylnitronitrosoguanidine results in increased secretion of TNF protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TNF protein]
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased secretion of TNF protein] 		CTD PMID:36403744 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TNFRSF25 mRNA CTD PMID:12634122 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:167,904,786...167,909,052 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TOP2A mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TOP2A mRNA CTD PMID:19840844 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases response to substance
increases response to substance
increases acetylation
multiple interactions
decreases expression 		ISO
EXP 		Methylnitronitrosoguanidine results in increased expression of TP53 mRNA; Methylnitronitrosoguanidine results in increased expression of TP53 protein
TP53 protein mutant form results in decreased susceptibility to Methylnitronitrosoguanidine
TP53 protein results in increased susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in increased acetylation of TP53 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TP53 protein]; resveratrol inhibits the reaction [Methylnitronitrosoguanidine results in increased acetylation of TP53 protein]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TRP53 mRNA; Cadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TRP53 protein]
ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein]; Methylnitronitrosoguanidine inhibits the reaction [TP53 protein binds to KDM8 protein]; TP53 protein mutant form inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein] 		CTD PMID:9667752 PMID:11516527 PMID:12135628 PMID:12634122 PMID:15589979 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tram1 translocation associated membrane protein 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TRAM1 mRNA CTD PMID:12634122 NCBI chr 5:10,425,710...10,450,669
Ensembl chr 5:10,425,633...10,470,056 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of TSC22D1 mRNA CTD PMID:12634122 NCBI chr15:58,159,612...58,260,244
Ensembl chr15:58,159,952...58,183,322 		JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TTC3 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TTC3 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TTC3 mRNA CTD PMID:19840844 NCBI chr11:47,158,766...47,258,612
Ensembl chr11:47,158,792...47,258,418 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions
increases expression 		ISO KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TWIST1 protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TWIST1 protein]
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TWIST1 protein] 		CTD PMID:38184286 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TXN1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TXN1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TXN1 mRNA CTD PMID:19840844 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of UBC mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of UBC mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of UBC mRNA CTD PMID:19840844 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275 		JBrowse link
G Ubd ubiquitin D increases expression EXP Methylnitronitrosoguanidine results in increased expression of UBD mRNA CTD PMID:12082013 NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,390,600...1,413,965 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of UCHL1 mRNA CTD PMID:12634122 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of UCP2 mRNA CTD PMID:19840844 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions 		EXP Methylnitronitrosoguanidine results in increased expression of VCAM1 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VCAM1 protein] 		CTD PMID:36403744 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vim vimentin increases expression
multiple interactions 		ISO Methylnitronitrosoguanidine results in increased expression of VIM mRNA; Methylnitronitrosoguanidine results in increased expression of VIM protein
KLF7 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of VIM mRNA]
KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM mRNA]]; KLF7 protein inhibits the reaction [MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM protein]]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM mRNA]; MIR520F inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of VIM protein] 		CTD PMID:12634122 PMID:12773770 PMID:38184286 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of WARS1 mRNA CTD PMID:12634122 NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645 		JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of WNT2 mRNA CTD PMID:12634122 NCBI chr 4:47,294,300...47,340,284
Ensembl chr 4:47,294,300...47,421,976 		JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [YY1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [YY1 protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:133,471,562...133,497,257 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        explosive 4759
          nitroguanidine 751
            N-methyl-N'-nitro-N-nitrosoguanidine 322
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organonitrogen compound 19403
                                guanidines 2373
                                  guanidine 761
                                    nitroguanidine 751
                                      N-methyl-N'-nitro-N-nitrosoguanidine 322
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